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Статті в журналах з теми "Multicenter clinical trial":
Justice, Jamie N., George A. Kuchel, Nir Barzilai, and Stephen Kritchevsky. "BIOMARKER STRATEGIES FOR GEROSCIENCE-GUIDED CLINICAL TRIALS." Innovation in Aging 3, Supplement_1 (November 2019): S745—S746. http://dx.doi.org/10.1093/geroni/igz038.2731.
Chung, Kevin C., and Jae W. Song. "A Guide to Organizing a Multicenter Clinical Trial." Plastic and Reconstructive Surgery 126, no. 2 (August 2010): 515–23. http://dx.doi.org/10.1097/prs.0b013e3181df64fa.
Chung, Kevin C., Sunitha Malay, and Melissa J. Shauver. "The Complexity of Conducting a Multicenter Clinical Trial." Plastic and Reconstructive Surgery 144, no. 6 (December 2019): 1095e—1103e. http://dx.doi.org/10.1097/prs.0000000000006271.
Abbas, E. E., P. Dham, and D. Shaker. "A multicenter clinical trial in the Arab world." Transplantation Proceedings 36, no. 6 (July 2004): 1801–4. http://dx.doi.org/10.1016/j.transproceed.2004.07.037.
Craig, M. T., N. S. Abramson, P. Safar, and H. Herzog. "Deferred consent in a multicenter prehospital clinical trial." Annals of Emergency Medicine 23, no. 3 (March 1994): 619–20. http://dx.doi.org/10.1016/s0196-0644(94)80337-4.
Kim, Paul, Paul E. Beaulé, Yves LaFlamme, and Michael Dunbar. "Prospective Multicenter Clinical Trial of Hip Resurfacing Arthroplasty." Journal of Arthroplasty 23, no. 2 (February 2008): 318. http://dx.doi.org/10.1016/j.arth.2008.01.235.
Cauch, Karen. "Early patient accrual for a multicenter clinical trial." Controlled Clinical Trials 12, no. 5 (October 1991): 717. http://dx.doi.org/10.1016/0197-2456(91)90330-o.
HODISH, ISRAEL, RICHARD M. BERGENSTAL, MARY L. JOHNSON, REBECCA A. PASSI, ANUJ BHARGAVA, NATALIE YOUNG, DAVIDA F. KRUGER, ANGELA HAILEY, EMILY UNGER, and ERAN BASHAN. "Digitally Enhanced Insulin Therapy—A Multicenter Clinical Trial." Diabetes 67, Supplement 1 (May 2018): 353—OR. http://dx.doi.org/10.2337/db18-353-or.
Howard, Virginia J. "Recruitment of clinicaal centers in an investigator-initiated multicenter clinical trial." Controlled Clinical Trials 13, no. 5 (October 1992): 394. http://dx.doi.org/10.1016/0197-2456(92)90084-d.
KITABATAKE, AKIRA. "Ideal way of multicenter clinical trial - science and ethics. Clinical trial in circulatory diseases." Nihon Naika Gakkai Zasshi 86, no. 9 (1997): 1680–83. http://dx.doi.org/10.2169/naika.86.1680.
Дисертації з теми "Multicenter clinical trial":
Zahnert, Thomas, Hubert Löwenheim, Dirk Beutner, Rudolf Hagen, Arneborg Ernst, Hans-Wilhelm Pau, Thorsten Zehlicke, et al. "Multicenter Clinical Trial of Vibroplasty Couplers to Treat Mixed/Conductive Hearing Loss: First Results." Karger, 2016. https://tud.qucosa.de/id/qucosa%3A70599.
Stockddale, Cynthia R. "A Comparison of Community-Based Centers versus University-Based Centers in Clinical Trial Performance." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002472.
Pereira, Joanna Tatith. "Longevidade de restaurações adesivas em dentes decíduos posteriores submetidos à remoção total ou seletiva de tecido cariado : um estudo multicêntrico." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/152662.
The selective caries removal technique (SCR) for active deep carious lesions in deciduous and permanent teeth is already a consensus in the literature and is supported by studies that demonstrate excellent clinical, radiographic and microbiological results. However, the longevity of restorations performed after the SCR, mainly in primary dentition, has generated some doubts and concerns about its performance, deserving clarification. This multicenter study aimed to compare the success rate of adhesive restorations performed on posterior deciduous teeth after total or selective caries removal over 30 months Methods: Children between 4 - 8 years old with at least two active cavitated lesions in deep dentin (inner half of the dentin in the evaluation of the interproximal RX and with at least 1mm of dentin separating the carious lesion of the pulp) and that met the inclusion and exclusion criteria participated in the study. For each child, teeth were randomized and submitted to one of the treatment groups: total caries removal (TCR - control group) or SCR (test group). Children could have more than 2 teeth included. In cases of pulp exposure, data were analyzed and the tooth was excluded from the sample. Four institutions participated in the study (Federal University of Rio Grande do Sul, Peruvian University Cayetano Heredia and International Universidad of Ecuador), resulting in four pediatric dentists who performed the caries removal procedures and subsequent restorations in composite resin. Clinical evaluation was performed at baseline, 6, 12, 18, 24 and 30 months. All procedures were performed under local anesthesia and rubber dam use. Sociodemographic characteristics were collected at the baseline and clinical characteristics as dmft and visible plaque and gingival bleeding index were collected in all follow-up periods. Radiographs were taken only at baseline and restorations were clinically assessed at baseline, 6, 12, 18, 24 and 33 months by a blinded, trained and calibrated operator in each institution. The characteristics of the restorations were recorded according to an adaptation of the FDI criteria. Survival estimates for restoration longevity were evaluated using the Kaplan-Meier method. We also estimated the annual failure rate of the restorations. Cox regression model with shared frailty was performed to assess differences in survival rates of the restoration according to the intervention treatment, institution and clinical and demographic characteristics of the sample. Results: one hundred and six children (51 boys and 55 girls) collaborated with 278 teeth submitted to adhesive restorations (137 after TCR and 141 after SCR). Pulp exposure occurred in eight teeth (2.8%) allocated to TCR, and in four (1.4%) allocated to SCR group. The overall success rate of restorations was 87.1% (85.4% for TCR and 88.7% for SCR) and mean survival time was 30.3 months. The annual failure rate was 7% after 24 months of follow-up. There were no differences in the risk of failure according to the treatment group (HR 0.75;95%CI:0.38-1.46) and institution (USP HR 0.44;95%CI:0.94-2.09; PERU HR 0.92;95%CI:0.26-3.19; ECUADOR HR 1.39;95%CI:0.45-4.28). Analogous observations were found regarding all the clinical and demographic variables. Conclusions: Composite restorations of active deep carious lesions performed in posterior primary teeth show satisfactory survival of 87.1% after 33 months of follow-up, regardless of the technique performed for carious tissue removal.
Hauke, Christina [Verfasser], Alexander [Akademischer Betreuer] Gerlach, and Susanne [Akademischer Betreuer] Zank. "The role of therapist adherence in a multicenter randomized clinical trial of patients with panic disorder and agoraphobia / Christina Hauke. Gutachter: Alexander Gerlach ; Susanne Zank." Köln : Universitäts- und Stadtbibliothek Köln, 2014. http://d-nb.info/1065801068/34.
Xu, Shilin. "Contributions to the statistical analysis of multicenter clinical trials." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239146.
Hardy, Rebecca Jane. "Meta-analysis techniques in medical research : a statistical perspective." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1995. http://researchonline.lshtm.ac.uk/682268/.
Familusi, Mary Ajibola. "Analysis of clustered competing risks with application to a multicentre clinical trial." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/23763.
Niangoran, Bessekon. "Apport du monitorage statistique des données dans la gestion des essais cliniques multicentriques en Afrique." Electronic Thesis or Diss., Bordeaux, 2023. http://www.theses.fr/2023BORD0436.
Data quality is a fundamental concern of clinical research. To ensure this quality, continuous data monitoring must be practiced. International drug regulatory bodies recommend that this monitoring be targeted, based on a risk analysis. From this recommendation emerged the concept of “centralized statistical monitoring” (CSM) which consists of detecting atypical distributions of variables in a center compared to other centers. This thesis identifies existing CSM methods, proposes new ones, and compares the performances of each. In the first part, we recall the interest of the subject, in a context marked by the increase in the number of clinical trials, the need to work increasingly remotely and the need for new monitoring paradigms. In the second part, we identify existing CSM methods, analyze their performances reported in the literature and draw two major observations: (i) the number of methods is limited; (ii) their assessments through simulation studies and applications on real data reported in the literature are also limited. In the third part we propose two new CSM methods to detect the distributions of atypical variables in multicenter trials, one for quantitative data which uses a standardized distance measure (Distance method) and the other for categorical data, which uses a hierarchical Bayesian beta-binomial (HBBB) model. We evaluate the performance of these methods using clinical trial simulations and then compare them to other CSM methods identified in the literature. For quantitative data, the Distance method has performances similar to the method proposed by Desmet et al., and superior to those of the two other existing methods. For categorical data, the HBBB method has similar performance to the only other existing method, also proposed by Desmet et al. For both methods, Distance and HBBB, the sensitivity is poor overall, but the specificity is excellent, including in many scenarios involving small sample sizes. The low sensitivity suggests that the CSM is an additional tool that can be used in addition to other conventional monitoring procedures, but does not replace them. The strong specificity and user-friendliness suggest that these methods can be routinely applied in all clinical trials, as their use will not be centrally time consuming and will not create unnecessary workload in investigational centers
Rotolo, Federico. "Frailty multi-state models for the analysis of survival data from multicenter clinical trials." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3422564.
I modelli a rischi proporzionali sono tra i modelli di regressione più conosciuti ed utilizzati in analisi di sopravvivenza. In modelli multi-stato sono una loro generalizzazione che permette di considerare congiuntamente diversi tipi di eventi e le loro interrelazioni, mentre i modelli di tipo frailty introducono effetti casuali per tenere conto di fattori di rischio non osservati, eventualmente in comune tra soggetti appartenenti allo stesso gruppo. L’integrazione dei modelli multi-stato e dei modelli frailty è interessante al fine di controllare l’eterogeneità non osservata in presenza di strutture complesse di eventi, particolarmente interessante nel caso di studi clinici multicentro. In questa tesi proponiamo di incorporare frailty annidati nella funzione di rischio transizione-specifica, quindi sviluppiamo e valutiamo metodi di inferenza sia parametrica che semiparametrica. Studi di simulazione, effettuati grazie a un metodo innovativo per generare dati di sopravvivenza multi-stato dipendenti, mostrano che l’inferenza parametrica è corretta ma estremamente imprecisa, mentre i metodi semiparametrici sono molto competitivi per valutare l’effetto delle covariate. Due casi-studio relativi a studi clinici multicento in oncologia vengono quindi presentati. La natura multi-stato dei modelli permette di studiare l’effetto del trattamento tenendo conto degli eventi intermedi, mentre la presenza di frailty riduce l’effetto di attenuazione dovuto ai gruppi di pazienti. Infine, presentiamo due nuovi strumenti software, uno per stimare modelli frailty parametrici con fino a venti possibili combinazioni di distribuzioni baseline e frailty, e un altro che implementa metodi di inferenza semiparametrica per modelli frailty multilivello, essenziali per stimare i nuovi modelli multi-stato con frailty annidati.
Lundberg, Elena. "Growth hormone responsiveness in children : results from Swedish multicenter clinical trials of growth hormone treatment." Doctoral thesis, Umeå universitet, Pediatrik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-134569.
Книги з теми "Multicenter clinical trial":
Margie, Patlak, Nass Sharyl J, Micheel Christine, National Cancer Policy Forum (U.S.)., and Institute of Medicine (U.S.), eds. Multi-center phase III clinical trials and NCI cooperative groups: Workshop summary. Washington, D.C: National Academies Press, 2009.
Margie, Patlak, Nass Sharyl J, Micheel Christine, National Cancer Policy Forum (U.S.)., and Institute of Medicine (U.S.), eds. Multi-center phase III clinical trials and NCI cooperative groups: Workshop summary. Washington, D.C: National Academies Press, 2009.
Demitrack, Mark A., and Sarah H. Lisanby. Methodological issues in clinical trial design for TMS. Edited by Charles M. Epstein, Eric M. Wassermann, and Ulf Ziemann. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780198568926.013.0039.
Mecca, Adam P., and Rajesh R. Tampi. Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer’s Disease. Edited by Ish P. Bhalla, Rajesh R. Tampi, Vinod H. Srihari, and Michael E. Hochman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190625085.003.0015.
Jones, Byron. The Design and Analysis of Multicentre Clinical Trials. John Wiley and Sons Ltd, 2008.
Webb, Jason A., and Arif H. Kamal. Palliative Oxygen Versus Room Air for Refractory Dyspnea (DRAFT). Edited by Nathan A. Gray and Thomas W. LeBlanc. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190658618.003.0017.
Patlak, Margie, Institute of Medicine, National Cancer Policy Forum, Christine Micheel, and Sharyl Nass. Multi-Center Phase III Clinical Trials and NCI Cooperative Groups: Workshop Summary. National Academies Press, 2009.
Patlak, Margie, Institute of Medicine, National Cancer Policy Forum, Christine Micheel, and Sharyl Nass. Multi-Center Phase III Clinical Trials and NCI Cooperative Groups: Workshop Summary. National Academies Press, 2009.
Patlak, Margie, Institute of Medicine, National Cancer Policy Forum, Christine Micheel, and Sharyl Nass. Multi-Center Phase III Clinical Trials and NCI Cooperative Groups: Workshop Summary. National Academies Press, 2009.
Частини книг з теми "Multicenter clinical trial":
Svantesson, Eleonor, Eric Hamrin Senorski, Alicia Oostdyk, Yuichi Hoshino, Kristian Samuelsson, and Volker Musahl. "Multicenter Study: How to Pull It Off? The PIVOT Trial." In Basic Methods Handbook for Clinical Orthopaedic Research, 403–13. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-58254-1_43.
Hébert, P. C. "Transfusion Requirements in Critical Care: A Multicenter Controlled Clinical Trial." In Yearbook of Intensive Care and Emergency Medicine, 202–17. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-72038-3_18.
Rutsch, Wolfgang, Patrick W. Serruys, Guy R. Heyndrickx, Nicolas Danchin, E. Gijs Mast, William Wijns, Jeroen Vos, and J. Stibbe. "CARPORT — Coronary artery restenosis prevention on repeated thromboxane antagonism. A multicenter randomized clinical trial." In Developments in Cardiovascular Medicine, 351–64. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1854-5_20.
Kichikawa, Kimihiko, Shoji Sakaguchi, Wataru Higashiura, and Hideo Uchida. "Multicenter Clinical trial of Zenith AAA Endovascular Graft for Abdominal Aortic Aneurysm in Japan." In Advances in Understanding Aortic Diseases, 135. Tokyo: Springer Japan, 2009. http://dx.doi.org/10.1007/978-4-431-99237-0_22.
Koh, Jason L., Shital Parikh, and Beth Shubin Stein. "Conducting a Multicenter Trial: Learning from the JUPITER (Justifying Patellar Instability Treatment by Early Results) Experience." In Basic Methods Handbook for Clinical Orthopaedic Research, 415–25. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-58254-1_44.
Kasuya, H. "Clinical Trial of Nicardipine Prolonged-Release Implants for Preventing Cerebral Vasospasm: Multicenter Cooperative Study in Tokyo." In Early Brain Injury or Cerebral Vasospasm, 165–67. Vienna: Springer Vienna, 2011. http://dx.doi.org/10.1007/978-3-7091-0356-2_30.
Ginsberg, Myron D. "High-Dose Albumin for Neuroprotection in Acute Ischemic Stroke: From Basic Investigations to Multicenter Clinical Trial." In Translational Stroke Research, 691–719. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-9530-8_34.
Friedman, Lawrence M., Curt D. Furberg, and David L. DeMets. "Multicenter Trials." In Fundamentals of Clinical Trials, 427–40. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-1586-3_20.
Friedman, Lawrence M., Curt D. Furberg, and David L. DeMets. "Multicenter Trials." In Fundamentals of Clinical Trials, 345–56. New York, NY: Springer New York, 1998. http://dx.doi.org/10.1007/978-1-4757-2915-3_19.
Friedman, Lawrence M., Curt D. Furberg, David L. DeMets, David M. Reboussin, and Christopher B. Granger. "Multicenter Trials." In Fundamentals of Clinical Trials, 501–18. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-18539-2_21.
Тези доповідей конференцій з теми "Multicenter clinical trial":
Ingeholm, Mary-Lou, Betty A. Levine, Florian Eichler, Huacheng Tu, Gerardo Jimenez-Sanchez, and Hugo Moser. "Multicenter clinical trial using next-generation Internet technology." In Medical Imaging 2001, edited by Eliot L. Siegel and H. K. Huang. SPIE, 2001. http://dx.doi.org/10.1117/12.435470.
Borges, Guilherme Ferreira, Hélio Rubens de Carvalho Nunes, Gustavo José Luvizutto, Taís Regina da Silva, and Rodrigo Bazan. "Lessons of a multicenter noninvasive brain stimulation trial in patients with unilateral spatial neglect after stroke: barriers to trial participation from a developing country." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.482.
Zaccaria, Gian Maria, Samanta Rosati, Cristina Castagneri, Simone Ferrero, Marco Ladetto, Mario Boccadoro, and Gabriella Balestra. "Data quality improvement of a multicenter clinical trial dataset." In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2017. http://dx.doi.org/10.1109/embc.2017.8037043.
Tavanapong, Wallapak, JungHwan Oh, Gavin Kijkul, Jacob Pratt, Johnny Wong, and Piet deGroen. "Real-Time Feedback for Colonoscopy in a Multicenter Clinical Trial." In 2020 IEEE 33rd International Symposium on Computer-Based Medical Systems (CBMS). IEEE, 2020. http://dx.doi.org/10.1109/cbms49503.2020.00010.
Winslow, C. J., D. P. Edelson, M. M. Churpek, M. Taneja, M. Kharasch, A. Datta, P. McNulty, and M. Halasyamani. "The Impact of an Early Warning Score on Hospital Mortality: A Multicenter Clinical Intervention Trial." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2462.
Santos, Gabriel Cerqueira, Caio de Almeida Lellis, Bruno Coelho Duarte Oliveira, Letícia Romeira Belchior, Caíque Seabra Garcia de Menezes Figueiredo, and Ledismar José da Silva. "Botulinum toxin type A in the treatment of Myofascial Pain Syndrome: A Systematic Review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.263.
Galperin-Aizenberg, Maya, Hyun J. G. Kim, Peiyun Lu, Daniel Chong, Laura Guzman, Heidi Coy, Matthew S. Brown, and Jonathan G. Goldin. "Reproducibility Of Lung Volume Measurements Using Computed Tomography From Repeated Scans In A Multicenter Clinical Trial." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4607.
Karimzadeh, A., SA Raeissadat, S. Erfani fam, and L. Sedighipour. "SAT0604 Autologous blood and corticosteroid local injection in treatment of plantar fasciitis (randomized, controlled multicenter clinical trial)." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.1771.
Meyer, JS, S. Seefeldt, J. Lange, M. Heiss, D. Seidel, and R. Lefering. "BIOLAP: Biological versus synthetic mesh in laparoscopic hernia repair-a randomized multicenter, prospective, self-controlled clinical trial." In Viszeralmedizin 2017. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1605325.
Maas, M., H. Neumann, H. Shirin, L. Katz, A. Benson, A. Kahloon, E. Soons, et al. "A novel computer-aided polyp detection system in daily clinical care: an international multicenter, randomized, tandem trial." In ESGE Days 2023. Georg Thieme Verlag KG, 2023. http://dx.doi.org/10.1055/s-0043-1765015.
Звіти організацій з теми "Multicenter clinical trial":
Robles, Marcelo, Claudio Dachevsky, and Héctor Llovera. Prospective study: evaluation of the efficacy and longevity of cross-linked hyaluronic acid in nasolabial folds filling. Editorial Lugones, December 2023. http://dx.doi.org/10.47196/0574.
Viskochil, David, Brigitte Widemann, Jan Friedman, Rosalie Ferner, and Arie Perry. Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1: A Multicenter Project With 3 Clinical Trials. Fort Belvoir, VA: Defense Technical Information Center, June 2006. http://dx.doi.org/10.21236/ada460467.