Дисертації з теми "Mucosal surfaces"
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Tosh, F. Donald. "Adherence of Candida albicans to mucosal surfaces." Thesis, University of Glasgow, 1991. http://theses.gla.ac.uk/40982/.
Повний текст джерелаFrede, Annika. "Modulation of inflammatory responses at mucosal surfaces by nanoparticle-based siRNA delivery." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/modulation-of-inflammatory-responses-at-mucosal-surfaces-by-nanoparticlebased-sirna-delivery(188e5303-0b29-4d14-8635-7d1fcf448270).html.
Повний текст джерелаO'Mahony, Rachel Mary. "Novel inhibitors of adhesin-receptor interactions involved in microbial infection at mucosal surfaces." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1446253/.
Повний текст джерелаSid, Hicham [Verfasser]. "Host-pathogen interactions during mono- and multicausal infections of avian mucosal surfaces / Hicham Sid." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2016. http://d-nb.info/1123677514/34.
Повний текст джерелаIslam, Ayesha. "Interactions of human immunodeficiency virus type 1 with mucosal epithelial surfaces and Candida albicans." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/interactions-of-human-immunodeficiency-virus-type-1-with-mucosal-epithelial-surfaces-and-candida-albicans(c8f83c82-f3af-469e-9790-8626f4b96d0f).html.
Повний текст джерелаStange, Jörg. "Studies on host-pathogen interactions at mucosal barrier surfaces using the murine intestinal parasite Eimeria falciformis." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16716.
Повний текст джерелаThe roles of Th1 and Th17 responses as mediators of host protection and pathology in the intestine are the subjects of intense research. Here we investigated a model of intestinal inflammation driven by the intracellular apicomplexan parasite Eimeria falciformis. Although IFN-γ was the predominant cytokine during E. falciformis infection in wild type mice, it was found to be dispensable for host defence and the development of infection-driven intestinal inflammation. E. falciformis-infected IFN-γR-/- and IFN-γ-/- mice developed dramatically exacerbated body weight loss and intestinal pathology, but surprisingly harboured fewer parasites. This was associated with a striking increase in parasite-specific IL-17A and IL-22 production in the mesenteric lymph nodes and at the site of infection. Concurrent neutralisation of IL-17A and IL-22 in E. falciformis infected IFN-γR-/- mice resulted in a reduction in infection induced body weight loss and inflammation and significantly increased parasite shedding. Taken together these data demonstrate for the first time an anti-parasitic effect of IL-22 during an intestinal infection and suggest that IL-17A and IL-22 have redundant roles in driving intestinal pathology in the absence of IFN-γ signalling. To further develop E. falciformis as a model system, we established transfection of E. falciformis sporozoites using various plasmids that contain the fluorescent reporter YFP and the resistance marker DHTS. Sporozoites applied rectally to mice were shown to complete their life cycle, albeit with a lower efficiency in comparison to oral infection with oocysts. Repeated in vivo selection using pyrimethamine and/or FACS and manual sorting led to a maximum percentage of 34 % YFP-expressing oocysts. Taken together, we demonstrate for the first time transfection of E. falciformis and provide perspectives for further work on the establishment of a stable transgenic parasite line.
Shawky, Samia Ali. "Maternally acquired immunoglobulin G in turkey poults : distribution on mucosal surfaces and protective role in the gut /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487842372894338.
Повний текст джерелаClarke, Christopher John. "Antigen presentation to mucosal surfaces : the influence of liposome entrapment and cholera toxin on the immune response to fed protein antigens." Thesis, University of Bristol, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330040.
Повний текст джерелаStange, Jörg [Verfasser], Richard [Akademischer Betreuer] Lucius, Kai [Akademischer Betreuer] Matuschewski, and Alf [Akademischer Betreuer] Hamann. "Studies on host-pathogen interactions at mucosal barrier surfaces using the murine intestinal parasite Eimeria falciformis / Jörg Stange. Gutachter: Richard Lucius ; Kai Matuschewski ; Alf Hamann." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://d-nb.info/1033837199/34.
Повний текст джерелаBurden, Matthew. "An investigation into making a bispecific scFv antibody that recognises both pIgR. and IgG Fc by phage display technology in order to transport IgG to mucosal surfaces." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486114.
Повний текст джерелаHoward, Sean Ryan. "Mucosal surface molecules of the urinary bladder." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ38592.pdf.
Повний текст джерелаBäckhed, Fredrik. "Role of toll-like receptors in host responses to mucosal bacterial infections /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-367-8/.
Повний текст джерелаChen, Nan. "Size and surface properties determining nanoparticle uptake and transport in the nasal mucosa." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1562.
Повний текст джерелаPountney, David James. "Studies of the mechanism and regulation of intestinal iron absorption with special reference to a mucosal surface reducing activity." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339140.
Повний текст джерелаJuel, Ingebjørg S. "Intestinal injury and recovery after ishemia - An experimental study on restitution of the surface epithelium, intestinal permeability, and release of biomarkers from the mucosa." Doctoral thesis, Norwegian University of Science and Technology, Department of Cancer Research and Molecular Medicine, 2007. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-1817.
Повний текст джерелаNielson, Joseph R. "Three Dimensional Characterization of Vocal Fold Fluid Structure Interactions." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3662.
Повний текст джерелаVanCott, John Louis. "Protective immunity against transmissible gastroenteritis virus (TGEW) : enumeration of antibody-secreting cells and identification of mononuclear cell surface markers in systemic and mucosal lymphoid tissues of young pigs exposed to TGEV... /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487842372895095.
Повний текст джерелаMurray, Preston Roylance. "Flow-induced Responses of Normal, Bowed, and Augmented Synthetic Vocal Fold Models." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2873.
Повний текст джерелаLegrand, Thibault Philippe Raymond Albert. "The functional role of the fish microbiome." Thesis, 2021. https://hdl.handle.net/2440/135964.
Повний текст джерелаThesis (Ph.D.) -- University of Adelaide, School of Biological Sciences, 2021
Tsai, Jeng-Shiang, and 蔡政翔. "Surface assembly of Poly (I:C) on Polyethyleneimine modified Gelatin Nanoparticles as Immunostimulatory Carriers of Antigen for Mucosal Delivery." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/47917116109783463654.
Повний текст джерела國立臺灣大學
醫學工程學研究所
104
In the past, the vaccine has been research to attack the disease. This disease is including about the infectious disease. However, up to now the vaccine administrations are used to inject the vaccine in body. The injection owing to cause the pain, many people don’t want to accept the vaccine injection. Because of this reason, we want to use the mucosal delivery to change the disadvantage of the injection. The history of making vaccine has been used to achieve the goals which are better effective result and the safe. However, Live/attenuated vaccines have the good result but they are not safe for the patient. And the inactivated vaccine has decreased the dosage for the patient safe but it was not effective for curing the disease. We need to find the method which can decrease the dosage and have the better treatment effect. So we can use the delivery system to overcome this aim. The successful vaccine needs three important things including with antigen, delivery system and immune-stimulator. In this study, the Ovalbumin (OVA) was used to be the antigen model. The positive gelatin nanoparticles were used to be the material of delivery system. And the Poly (I: C) was used to be the immune-stimulator. Poly (I: C) and OVA were exposed on the outer surface of positive gelatin nanoparticles. The particle sizes of each positive gelatin nanoparticle with OVA and Poly (I: C) were controlled to smaller than 500nm. And the absorption of OVA at this particle has up to 95%. We demonstrated the Poly (I:C) and OVA incorporated positive gelatin nanoparticles effectively facilitated antigen uptake by mouse bone-marrow derived dendritic cells (BMDCs) and macrophage in vitro, led to higher expression of maturation markers, including CD80&86, and induced higher production of pro-inflammatory cytokine. In vivo use the C57BL/6 mice and the immunization procedure was repeated 2times at 2 weeks interval. C57BL/6 mice immunized by intranasal with the Poly (I: C) and OVA incorporated positive gelatin nanoparticles produced high levels of OVA-specific IgG antibodies in their serum and secretory-IgA (s-IgA) in nasal wash fluid. Spleen cells from mice receiving the Poly (I: C) and OVA incorporated positive gelatin nanoparticles were re-stimulated with OVA and showed significantly augmented levels of IFN-γ. In addition, intranasal administration of the Poly (I: C) and OVA incorporated positive gelatin nanoparticles resulted in complete protection against EG7 tumor challenge in C57BL/6 mice. Taken together, these results indicate that nasal administration of the Poly (I: C) and OVA incorporated positive gelatin nanoparticles mediates the development of an effective immunity against tumors and might be useful for further clinical anti-tumor application.