Дисертації з теми "Motility behaviour"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-19 дисертацій для дослідження на тему "Motility behaviour".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте дисертації для різних дисциплін та оформлюйте правильно вашу бібліографію.
Chacko, Sarah Jane. "Surface attachment behaviour in Rhodobacter sphaeroides." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:943eb194-b147-4cb9-bbc2-a9fd04a45949.
Повний текст джерелаBennett, Rachel R. "Physics of microorganism behaviour : motility, synchronisation, run-and-tumble, phototaxis." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:accc7f3c-b472-4bb9-b821-59725a54ccb7.
Повний текст джерелаLi, Martin. "Experimental study of swimming flagellated bacteria and their collective behaviour in concentrated suspensions." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4787.
Повний текст джерелаBatista, José Miguel Sebastiao Fernandes. "FAM49 : a novel regulator of the protrusive behaviour and motility of cells." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7690/.
Повний текст джерелаDombrowski, Christopher Charles. "Bacterial Motility: From Propulsion to Collective Behavior." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/195677.
Повний текст джерелаWei, Xueming. "Starvation-induced changes in motility and spontaneous switching to faster swarming behavior of Sinorhizobium Meliloti /." The Ohio State University, 1999. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488190595939615.
Повний текст джерелаCline, Mark Andrew. "Corticotrophin Releasing Hormone Modulation of Feed Intake, Gastric Motility, and Behavior in Low and High Body Weight Selected Lines of Chickens." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/27725.
Повний текст джерелаPh. D.
McLean, Amanda M. "BEHAVIORAL AND PHYSIOLOGICAL ADAPTATIONS ASSOCIATED WITH FEED INTAKE DURING TRANSITIONING CATTLE TO HIGH-GRAIN DIETS." UKnowledge, 2019. https://uknowledge.uky.edu/animalsci_etds/104.
Повний текст джерелаZeng, Yukai. "The Role of Substrate Stiffness on the Dynamics of Actin Rich Structures and Cell Behavior." Research Showcase @ CMU, 2014. http://repository.cmu.edu/dissertations/489.
Повний текст джерелаCisneros, Luis. "The Organized Melee: Emergence of Collective Behavior in Concentrated Suspensions of Swimming Bacteria and Associated Phenomena." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/195513.
Повний текст джерелаCastro, A. Felipe (Castro Arancibia) 1979. "Influence of dissolved oxygen on the physicochemical properties and migration behavior of selected bacterial pathogens." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116013.
Повний текст джерелаKeywords: bacterial adhesion, bacterial transport, DLVO, physicochemical characterization, dissolved oxygen, porous media.
Woo, Ho-Hyung, Csaba Laszlo, Stephen Greco, and Setsuko Chambers. "Regulation of colony stimulating factor-1 expression and ovarian cancer cell behavior in vitro by miR-128 and miR-152." BioMed Central, 2012. http://hdl.handle.net/10150/610206.
Повний текст джерелаIamshanova, Oksana. "Role of NALCN channel in prostate cancer metastatic behaviours." Thesis, Lille 1, 2017. http://www.theses.fr/2017LIL10205.
Повний текст джерелаImportantly, altered Na+ homeostasis was implemented in prostate carcinogenesis. However, until now nothing was known about a newly discovered Na+ leak channel, NALCN, and its role in prostate malignancy. Therefore, the main objective of this study was to investigate the involvement of NALCN as a potential candidate of the deregulated Na+-dependent signalling mechanisms in prostate cancer. Interestingly, NALCN represented distinctly different localization patterns and levels of expression between human healthy and cancer prostate tissues. Indeed, NALCN was expressed preferentially in highly aggressive prostate cancer cell lines. Na+ imaging results verified on functionality of NALCN channelosome in these cells. Our study also revealed that NALCN was not involved in cell cycle, viability, apoptosis and proliferation, but significantly affected motility, migration and invasiveness of the prostate cancer cells. Interestingly, it was already reported that protooncogene Src family kinase is recruited to the NALCN complex. In this study, we confirmed that NALCN and Src kinase are co-localized in human prostate cancer cells, particularly in the structures that represent invadopodia formation sites. Furthermore, in vivo studies confirmed that NALCN downregulation inhibits tumour growth and metastasis formation. Overall, these data provide evidence on NALCN contribution to the increased metastatic potential of human prostate cancer cells in vitro and in vivo. Therefore, NALCN could provide new perspective molecular target for the disease suppression, in particular at its advanced stages
Behrens, Verena. "Die Rolle des Glucosetransporters 8 (Slc2a8) in der Regulation der Glucosehomöostase, der Spermienmotilität sowie des Verhaltens." Phd thesis, Universität Potsdam, 2009. http://opus.kobv.de/ubp/volltexte/2009/3630/.
Повний текст джерелаThe family of facilitative glucose transporters consists of 14 different members in human, which are divided into three classes (Joost and Thorens, 2001). The class III family member GLUT8 contains an amino-terminal dileucine sorting signal, which is part of the highly conserved [DE]XXXL[LI] motif responsible for the localization of GLUT8 in lysosomes and late endosomes (Augustin et al., 2005). To date there is no stimulus known, which translocates the transporter to the plasma membrane, therefore an intracellular function rather than at the cell surface is considered (Widmer et al., 2005). The aim of the present dissertation was to analyze the intracellular role of GLUT8 in the regulation of whole body glucose homeostasis, by the characterization of the corresponding knockout mice (Slc2a8-/-). Slc2a8-/- mice were viable and showed no obvious disparity to their wild-type littermates. However, analysis of the offspring distribution of heterozygous mating provided a reduced number of born Slc2a8-/- offspring which differed significantly from the expected Mendelian distribution. Because Slc2a8 mRNA is expressed at highest levels in the testis and the female Slc2a8-/- mice showed no alterations in fertility, we further investigated the function of Slc2a8-/- spermatozoa. An impaired mitochondrial condensation in the Slc2a8-/- spermatozoa, which was associated with decreased ATP levels resulted in a reduced number of motile Slc2a8-/- sperm, which appeared to be responsible for the reduced number of born Slc2a8-/- offspring. Therefore in sperm cells GLUT8 seems to be important for an intracellular transport process, which exerts an influence on the oxidative phosphorylation in the mitochondria. In the brain Slc2a8 is expressed at highest levels in the hippocampus, which is important for the regulation of physical activity, exploration behaviour, memory and learning as well as anxiety related behaviour. Additionally, GLUT8 was detected in the hypothalamus, which is amongst others involved in the regulation of food intake. The Slc2a8-/- mice showed a significant increase in locomotor activity, which indicates a moderate undersupply of the hippocampus area. According to this finding the group of Membrez et al. (2006) observed a raised cell proliferation in the hippocampus of Slc2a8-/- mice. The fact that no alterations in food intake and only a moderate reduction in body weight was detected in Slc2a8-/- mice, indicates that GLUT8 is not important for the hypothalamic glucose sensing. The marginal decreased body weight of the Slc2a8-/- mice appeared to be associated with a slightly reduced weight of different tissues. Together with the lowered blood glucose concentrations and the apparently enhanced lifespan, the Slc2a8-/- mice showed symptoms of a moderate undersupply compareable to caloric restriction. Thus, we hypothesize that GLUT8 is important for the transport of sugar derivatives which arise during lysosomal/endosomal degradation of glycoproteins. These recycled sugars may serve as an additional energy source in the cell.
El-Dorghamy, Ahmed. "Children's potential mobility and appropriation of transport options in an informal settlement." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19549.
Повний текст джерелаThis study investigates the nature of children's actual and potential mobility in a case study of an informal settlement in a megacity of a developing country; namely Ezbet El-Haggana in Greater Cairo and explores the nature of the childhood phase of developing mobility practices and habits, not only as enabled by children themselves as commuters, but also as enabled by parents and the surrounding community and society. A theoretical framework was constructed through which children's mobility is investigated. It is based on Icek Ajzen's Theory of Planned Behavior and Vincent Kaufmann's conceptualization of Motility. The data was primarily collected through a field survey and focus groups. Results indicated high prevalence of child independent mobility (CIM) in the most frequent trip (to school), not only through active transport but also largely through different formal and informal transport services available. There are socio-cultural and socio-psychological factors among both the parents and the children that constitute the appropriation of mobility options that cater to children, either enabling or inhibiting their mobility. Through the experiences of children's mobility, the acquired skills and adaptive attitudes by both children and parents enhance children's potential mobility compared to children in wealthier communities that may be granted less mobility rights or have less competences among other factors. Inhibiting factors were also investigated; the specific case of acceptance of cycling for children. This exemplified prevalence of socio-psychological factors that overshadow practical and rational aspects of choice; it is articulated here as an appropriation gap. Results were finally associated with the conceptualization of appropriation to discuss implications for policy and for the discourses of mobility in disadvantaged communities.
Curatolo, Agnese. "Collective behaviours in living systems : from bacteria to molecular motors." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC244/document.
Повний текст джерелаThe first part of my thesis is devoted to studying the self-organization of engineered strains of run-and-tumble bacteria Escherichia coli. This project, carried out in collaboration with synthetic biologists at Hong Kong University, has as its objective the exploration and decipherment of a novel self-organization mechanism in multi-species bacterial colonies. This was inspired by the fascinating question of how bacterial ecosystems comprising several species of bacteria can self-organize in space. By considering systems in which two strains of bacteria mutually regulate their motilities, I was able to show that reciprocal density control is a generic pattern-formation pathway: if two strains tend tomutually enhance their motility (strain A moves faster when strain B is present, and conversely),they undergo a pattern formation process leading to demixing between the two strains. Conversely, mutual inhibition of motility leads to pattern formation with colocalization. These results were validated experimentally by our biologist collaborators. Subsequently, I extended my study to systems composed of more than two interacting species, finding simple rules that can predict the spatial self-organization of an arbitrary number of species whose motility is under mutual control. This part of my thesis opens up a new route to understand the self-organization of bacterial colonies with competing strains, which is an important question to understand the dynamics of biofilms or bacterial ecosystems in soils.The second problem treated in my thesis is inspired by the collective behaviour ofmolecular motorsmoving along microtubules in the cytoplasm of eukaryotic cells. A relevant model for the molecularmotors’ motion is given by a paradigmatic non-equilibrium system called Asymmetric Simple Exclusion Process (ASEP). In this one-dimensional lattice- based model, particles hop on empty neighboring sites at constant rates, with a leftright bias that drives the systemout of equilibrium. When connected at its ends to particle reservoirs, the ASEP is a prototypical example of one-dimensional boundary driven phase transitions. Realistic examples, however, seldom involve only one lane: microtubules are made of several tubulin tracks to which the motors can attach. In my thesis, I explained how one can theoretically predict the phase behaviour of complex multilane systems, in which particles can also hop between parallel lanes. In particular, I showed that the onedimensional phase transition seen in the ASEP survives this additional complexity but involves new features such as non-zero steady transverse currents and shear localization
Tout, Jessica Alyce. "Exploring the function and behaviour of natural populations of coral reef microbes." Thesis, 2016. http://hdl.handle.net/10453/43503.
Повний текст джерелаMicroorganisms live in tight associations with corals, but the ecological interactions and microbial functions and behaviours underpinning these relationships are not yet fully understood. The goal of this thesis is to define coral-microbe interactions by exploring how the composition, behaviour and function of microbial communities vary throughout a coral reef and how increasing sea water temperatures can affect coral-microbial relationships. As a first step to achieving this aim, In Chapter 1 we used metagenomics to characterise patterns in microbial composition and metabolic capacity across different niches, including coral-associated and non-coral associated microenvironments, on Heron Island, the Great Barrier Reef (GBR). We found that the composition and metabolic potential of coral reef bacteria is highly heterogeneous across a coral reef ecosystem, with a shift from an oligotrophy-dominated community (e.g. SAR11, Prochlorococcus, Synechococcus) in the open water and sandy substrate niches, to a community characterised by an increased frequency of copiotrophic bacteria (e.g. Vibrio, Pseudoalteromonas, Alteromonas) in the coral seawater niches. Among the major functional patterns observed were significant increases in genes associated with bacterial motility and chemotaxis in samples associated with the surfaces of coral colonies. The observation of increased motility and chemotaxis near to coral surfaces is notable given previous evidence that these phenotypes may be involved in coral disease processes. The research presented in this chapter was published in Microbial Ecology (2014 67 (3): 540-552) To investigate these patterns in chemotaxis further we next (Chapter 2) directly examined the potential ecological role of chemotaxis among coral-associated bacteria, by using laboratory based and in situ chemotaxis assays to test levels of chemotaxis among natural communities of coral reef microbes. We examined the behavioural responses towards several chemoattractants known to be released by corals and their symbiotic dinoflagelletes including amino acids, carbohydrates, ammonium chloride, and dimethylsulfonopropionate (DMSP). Using these approaches we found that bacteria associated with the surfaces of the corals exhibited high levels of chemotaxis, particularly towards DMSP and several amino acids. Levels of chemotaxis by coral-associated bacteria were consistently higher than those demonstrated by non-coral associated bacteria. This work was published in the ISME Journal (doi: 10.1038/ismej.2014.261) We next extended the in situ chemotaxis assays to examine the chemotactic behaviour of bacteria associated with other important coral reef organisms, sponges. These results redefine the sponge-symbiont acquisition paradigm whereby we show for that bacteria use chemotaxis to locate their sponge host on a coral reef. This work is in preparation for submission to the ISME Journal. After defining some of the functions and behaviours involved in coral reef microbiology, we next examined how these processes may shift under changing environmental conditions, associated with climate change. To determine how environmental variability, specifically thermal stress, influences bacterial community composition, behaviour and metabolic capacity, manipulation experiments were conducted using the coral Pocillopora damicornis. To investigate the dynamics of coral-associated vibrios under heat stress, in Chapter 4 we used Vibrio-specific amplicon sequencing approaches and qPCR to quantify shifts in the abundance and composition of natural populations of Vibrio, with a specific focus on the putative coral pathogen V. coralliilyticus. These experiments revealed that increasing seawater temperatures can favour the proliferation of potential coral pathogens among a natural mixed microbial community. This work has been published in Frontiers in Microbiology (6:432.doi: 10.3389/fmicb.2015.00432). In Chapter 5, we decided to explore the entire coral-associated community by using metagenomics and metatranscriptomics to investigate how the phylogeny and function of coral associated microbes shift resulting from increasing seawater temperatures. We found a dramatic shift in the community from Endozoicomonaceae being dominant in the control corals, while there was an appearance of the vibrios under increasing sea water temperatures in line with our findings from chapter 4. We also observed functional shifts that involved an upregulation of chemotaxis and motility genes at higher temperatures and were shown to be affiliated with vibrios, a genus which contains several putative coral pathogens. Taken together our data demonstrate that coral reef bacterial communities are highly dynamic and that key groups of copiotrophic bacteria have the capacity to use behaviours such as chemotaxis to use nutrient gradients to potentially locate and colonize benthic host animals including corals and sponges. Increasing seawater temperatures causes dramatic changes in the coral-associated bacterial community, allowing for the proliferation of potential coral pathogens and increased expression of behavioural phenotypes that may promote successful infection of corals.
Chen, Chih-Yen, and 陳志彥. "Regulation of Acylated and Des-acylated Ghrelin on Ingestive Behavior and Gastroduodenal Motility in Rats." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/52017497161954874580.
Повний текст джерела國立陽明大學
臨床醫學研究所
94
Ghrelin, a novel 28-amino acid peptide, was recently identified in the stomach. Acylated ghrelin has two unique biologic characteristics: (1) the only known orexigenic gut-brain peptide to increase meal size; (2) the unique post-translational modification of O-n-octanoylation at serine 3. Acylated ghrelin is involved in the regulation of gastrointestinal motility, cardiac performance, anxiety, and energy balance. On the other hand, des-acyl ghrelin has been reported to be devoid of any endocrine activities. However, plasma des-acyl ghrelin concentration accounts for more than 90% of total circulating ghrelin, and the ratio of des-acylated to acylated ghrelin in rat hypothalamus is 2: 1. The concept of des-acyl ghrelin as a traditionally-thought non-functional peptide has been particularly challenged. Recently, des-acyl ghrelin has been reported to inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT pathways in vitro, inhibit the proliferation of breast canrcinoma cell line, reduce glycerol release from rat epididymal adipocyte, directly bind to the membranes of PC-3 prostate tumor cells. Des-acyl ghrelin exhibits more potent cardiotropic action than acylated ghrelin on guinea pig papillary muscle ex vivo. More recently, des-acyl ghrelin has been shown to promote bone marrow adipogenesis in vivo by a direct peripheral action. Converging evidence indicate that des-acyl ghrelin has its unique biologic effects and roles. However, the effects of des-acyl ghrelin on ingestive behavior and gastrointestinal motility remain uninvestigated. Therefore, an in vivo whole animal model: rats, was used to conduct the prospective studies. Intraperitoneal injection of des-acyl ghrelin inhibited food intake in food-deprived rats, but not free-feeding rats. Intraperitoneal injection of acylated ghrelin stimulated food intake in both food-deprived and free-feeding rats. Capsaicin treatment did not alter intraperitoneal-injected des-acyl ghrelin induced anorectic effect, but blocked the anorexigenic effect induced by intraperitoneal-injected acylated ghrelin. Similarly, intrcisternal injection of des-acyl ghrelin inhibited food intake in food-deprived rats, but not free-feeding rats. Intracisternal injection of acylated ghrelin stimulated food intake in both food-deprived and free-feeding rats. For the studies of gastrointestinal motility, intravenous and intracerebroventricular injection of des-acyl ghrelin disrupted fasted antral motility, but not duodenal motility, in conscious rats. Capsaicin treatment did not alter the disruption of fasted antral motility induced by des-acyl ghrelin, but truncal vagotomy blocked it. Pretreatment with intracerebroventricular injection of the non-selective CRF and selective CRF2 receptor antagonists prevented the disruption of fasted antral motility induced by intravenous and intracerebroventricular injection of des-acyl ghrelin. However, pretreatment with intracerebroventricular injection of the selective CRF1 receptor antagonist did not prevent the disruption of fasted antral motility induced by intravenous and intracerebroventricular injection of des-acyl ghrelin. Another experiment indicated that intracisternal injection of des-acyl ghrelin dose-dependently inhibited the non-nutrient semiliquid gastric emptying, without altering the small intestinal transit. On the contrary, intracisternal injection of acylated ghrelin accelerated the non-nutrient semiliquid gastric emptying and increased the geometric center of the small intestinal transit, but did not alter the running percentage of small intestinal transit. For immunohistochemical studies, intraperitoneal injection of des-acyl and acylated ghrelin both increased c-fos expression in arcuate nucleus and paraventricular nucleus. Intraperitoneal injection of des-acyl ghrelin did not stimulated c-fos expression in the nucleus of the solitary tract, but, however, intraperitoneal injection of acylated ghrelin activated c-fos expression in the nucleus of the solitary tract. Taken together, the inhibitory effect of des-acyl ghrelin on food intake is short-lived and discrete in food-deprived rats. The effects of des-acyl ghrelin on food intake and fasted antral motility are not vagally or the nucleus of the solitary tract-mediated. The disruption of des-acyl ghrelin on fasted antral motility in conscious rats is probably through brain CRF2 receptor and vagal efferent dependent. The results from these studies opened up a lot of interesting questions about acylated and des-acyl ghrelin research dogmas. Des-acyl ghrelin regulated ingestive behavior, antral motility and gastric emptying. To investigate the target which des-acyl ghrelin acts on, especially the unique speficic receptor, as well as the physiologic and neuroanatomic interactions, might help understand the roles of des-acyl ghrelin in modulating ingestive behavior, gastrointestinal motility and energy balance. To develop reliable RIA or ELISA kits, for separate measurement of acylated and des-acyl ghrelin, also help translate basic science results into clinical research, efficiently solving the growing health and economic problems caused by obesity and anorexia-cacheixa in this modern society.
Srinivasa, Sandeep S. "Testing the Hypothesis of Quorum Sensing in Vibrio fischeri : Luminescence, Motility, and Biofilm." Thesis, 2017. http://hdl.handle.net/2005/3270.
Повний текст джерела