Дисертації з теми "Molecule identification"
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Ding, Fangyuan. "Single molecule mechanical sequencing and identification." Paris 6, 2012. http://www.theses.fr/2012PA066702.
Повний текст джерелаSAINT-ESPES, CECILE. "Identification des etats de molecule molle de hcn." Paris 11, 1993. http://www.theses.fr/1993PA112479.
Повний текст джерелаHeaslip, Aoife. "Identification of Small Molecule Effectors of the Toxoplasma." ScholarWorks @ UVM, 2008. http://scholarworks.uvm.edu/graddis/105.
Повний текст джерелаTam, Vernon Craig Goodheart. "Identification of a glycodelin-C binding molecule on humanspermatozoa." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39558666.
Повний текст джерелаTam, Vernon Craig Goodheart. "Identification of a glycodelin-C binding molecule on human spermatozoa." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39558666.
Повний текст джерелаMacaulay, Angus. "Identification of large molecule transfer in cumulus cell - oocyte intercommunication." Doctoral thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/26444.
Повний текст джерелаThe reports in this thesis explored the potential for large molecule communication between the cumulus cell and the oocyte hypothesizing that large molecules, including RNA, could be transferred to the oocyte for support during maturation. Exploration of the transzonal projections (TZPs) connecting the cumulus cells to the oocyte revealed that they are irregular in shape, can contain large organelles (mitochondria) and small cellular structures (ribosomes), and that these connections retract during oocyte maturation. Microvesicles were identified at the intercellular articulations capable of sharing large molecules between the cells. To determine if RNA is transferring as cargo between cells, nascent as well as total transcripts were evaluated in the TZPs and found moving towards the oocyte during maturation. Of the transcripts found in the TZPs during maturation, some were common to those increasing in abundance in the oocyte during maturation, and on the polyribosomes of the maturing oocyte, thus suggesting transfer and use of cumulus cell transcripts. A synthetic transcript provided to some cumulus cells for reconstruction with, and transfer to the oocyte, confirmed the potential to transfer mRNA and possibly proteins. Temporally, RNA transcripts were found to accumulate in TZPs during the hours post slaughter but prior to oocyte aspiration. Removal of the cumulus cells and this period of accumulation resulted in poor oocyte maturation. The requirement of vesicle mediated RNA transfer to the oocyte was tested. Inhibitors against RNA synthesis, transport, and vesicle formation were explored and found to reduced oocyte maturation. Focusing on mechanisms that could mediate transference, we assessed an RNA binding protein candidate with implications in premature ovarian insufficiency. Fragile X mental retardation protein (FMRP) was found in follicular cells and the oocyte throughout folliculogenesis and oogenesis. Based on known roles in translation control, FMRP was shown associated with translational machinery and storage granule proteins in the oocyte. Knockdown of this protein resulted in compromised rates of blastocyst formation. Knowing that exogenous transcripts contribute to oocyte development, and influence the molecular aspects of oocyte maturation adds another layer to our understanding of intercellular communication in the production of a healthy gamete. Future characterization of the transferred transcripts and the mechanisms in control of this process will improve our understanding of oocyte health and competence.
Saade, Khalil. "Identification of a potent anti-invasive molecule through mixed targeting design." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116059.
Повний текст джерела區大綱 and Tai-kong Au. "Identification of binding sites for ophiobolin a in the calmodulin molecule." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31236492.
Повний текст джерелаAu, Tai-kong. "Identification of binding sites for ophiobolin a in the calmodulin molecule /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19235288.
Повний текст джерелаKilian, Karin. "Identification of novel interaction partners for the leukocyte adhesion molecule L-selectin." [S.l. : s.n.], 2002. http://www.diss.fu-berlin.de/2002/295/index.html.
Повний текст джерелаLau, Lai-shan. "Identification of small molecule inhibitors of influenza A virus by chemical genetics." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39634413.
Повний текст джерелаLau, Lai-shan, and 劉麗珊. "Identification of small molecule inhibitors of influenza A virus by chemical genetics." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39634413.
Повний текст джерелаCollins, Súil. "The identification and development of small molecule inhibitors of amyloid β aggregation". Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/275823.
Повний текст джерелаLopez, Josue Alan. "Identification and validation of small molecule inhibitors for the Tiam1/SDC1 interaction." Thesis, University of Iowa, 2014. https://ir.uiowa.edu/etd/4683.
Повний текст джерелаKastl, Johanna Maria [Verfasser]. "Identification of small molecule inhibitors targeting the Mad2-Cdc20 interaction / Johanna Maria Kastl." Konstanz : Bibliothek der Universität Konstanz, 2014. http://d-nb.info/1097755517/34.
Повний текст джерелаKraus, Emma [Verfasser]. "Identification of small molecule inhibitors of clinically relevant human polyomavirus infections / Emma Kraus." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2019. http://d-nb.info/1240835515/34.
Повний текст джерелаKathayat, Dipak. "Identification of Novel Small Molecule Growth Inhibitors Specific to Avian Pathogenic Escherichia coli." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu150032603130236.
Повний текст джерелаMarx-Ferlemann, Fraua Christina [Verfasser], and Jan [Akademischer Betreuer] Pruszak. "Flow-cytometric identification and small molecule-based modulation of neuroblastoma subpopulations in vitro." Freiburg : Universität, 2021. http://d-nb.info/1238016537/34.
Повний текст джерелаAhmad, Izzuddin. "Identification and structure activity relationship of small molecule antagonists of the human P2X4 receptor." Thesis, University of East Anglia, 2018. https://ueaeprints.uea.ac.uk/68205/.
Повний текст джерелаHamzah, Nurasyikin Binti. "Identification and optimisation of small molecule modulators of Orai3 and TRPC4 as potential therapeutics." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/21990/.
Повний текст джерелаSaha, Bratati. "Identification and Validation of Small Molecules Inhibiting Human Adenovirus Replication." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39677.
Повний текст джерелаDührkop, Kai [Verfasser], Sebastian [Gutachter] Böcker, Oliver [Gutachter] Kohlbacher, and Juho [Gutachter] Rousu. "Computational methods for small molecule identification / Kai Dührkop ; Gutachter: Sebastian Böcker, Oliver Kohlbacher, Juho Rousu." Jena : Friedrich-Schiller-Universität Jena, 2018. http://d-nb.info/1170780628/34.
Повний текст джерелаArora, Ishan. "Identification of features contributing to binding promiscuity of small-molecule inhibitors for rapidly mutating targets." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/114313.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references (pages 21-27).
HIV infection has become a persistent worldwide epidemic despite the continuous development of novel inhibitors. A key challenge in combating HIV and other pandemic viral infections is the ability of the virus to mutate at an enormous rate and rapidly develop resistance to existing drugs. Among the various strategies that have been explored for the design of broadly binding HIV protease inhibitors, the substrate envelope hypothesis which is based on the idea of designing drugs that mimic the structural features of substrates has proved particularly effective. However, studies aimed at probing the substrate envelope hypothesis have found that the substrate envelope is a contributory but not sufficient property for robust binding and hence it is important to develop a better understanding of the other factors that contribute to binding promiscuity. This study investigated the key features which differentiate robust HIV protease inhibitors from susceptible HIV protease inhibitors by examining the interactions of certain known flat and nonflat binders with the different residues of HIV protease in terms of binding energy and number of contacts and correlating this analysis with the information about the mutational space of the virus. It was found that the promiscuous inhibitors, susceptible inhibitors and substrates all interact with the same set of HIV protease residues, some of which are vulnerable to primary mutations. The total contribution to the binding of an inhibitor/substrate to HIV protease from the HIV protease residues that are associated with primary mutations was observed to be a vital attribute separating flat binders from susceptible binders, with a greater contribution to binding from these residues translating into a higher susceptibility of the inhibitor to primary mutations. Certain strategies were proposed for incorporating these inferences in the computational drug design framework in order to generate robust HIV protease inhibitors. Although the analysis in this project was carried out using HIV protease as the model system, it is envisaged that the results obtained here would be generalizable to other rapidly mutating targets and hence these insights would facilitate drug design in the case of the outbreak of new epidemics of highly mutable infectious agents.
by Ishan Arora.
S.M.
Wang, Yao. "Identification of a Dual-Action Small Molecule with Potent Anti-diabetic and Anti-obesity Activity." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/103324.
Повний текст джерелаDoctor of Philosophy
Type 2 diabetes (T2D) is one of the fasting growing chronic diseases, which results from insulin resistance and pancreatic β-cell dysfunction. Even though there have been over thirty drugs approved to treat T2D in the United States, less than 25% of patients treated with anti-diabetic drugs achieved the glycemic target. Thus, more effective anti-diabetic drugs are still needed for improving glycemic control in patients with T2D. Incretins are a group of gut hormones and responsible for over 50% postprandial insulin secretion in humans, which have drawn considerable attention in research and developing a treatment strategy for T2D. Specifically, glucagon-like peptide 1 (GLP-1), the most important incretin that is secreted from enteroendocrine L-cells in response to food ingestion, plays a vital role in controlling blood glucose via potentiating glucose-stimulated insulin secretion (GSIS) and promoting pancreatic β-cell proliferation and survival. Therefore, targeting L-cells to induce GLP-1 secretion would be an alternative strategy for treating T2D. The goal of this research was to identify low-cost and safe naturally occurring agents as a primary or adjuvant treatment for T2D. Here, I found that a small molecule, elenolic acid (EA), which was synthesized in our lab but is also present in mature olive and extra virgin olive oil, dose-dependently stimulated GLP-1 secretion in mouse clonal L-cells and isolated mouse ileum crypts (containing L-cells). Further experiments showed that EA induced a rapid increase in intracellular [Ca2+]i and the production of inositol trisphosphate (IP3) in L-cells, indicating that EA activates phospholipase C (PLC)-mediated signaling, as IP3 is a direct product of PLC. Consistently, inhibition of PLC ablated EA-stimulated increase of [Ca2+]i and GLP-1 secretion in L-cells. In addition, EA-triggered GLP-1 secretion from L-cells was blocked by YM-254890, a Gαq inhibitor. In line with the in vitro study, a single dose of EA acutely elevated plasma GLP-1 concentration in mice, accompanied by improved oral glucose tolerance. Chronic administration of EA restored the impaired glucose and lipid homeostasis in diet-induced obese (DIO) mice, which may be partially due to promoting GLP-1 secretion and reduced hepatic gluconeogenesis. In addition, EA suppressed appetite, reduced food intake, and gastric emptying rate, as well as promoted weight loss in the DIO mice, demonstrating that it is also an anti-obesity agent. Further, EA treatment reduced lipid absorption and promoted hepatic fatty acid oxidation, as well as reversed abnormal plasma lipid profiles in the DIO mice. Consistently, EA exerted potent anti-diabetic action in predisposed diabetic mice (db/db), and its blood glucose-lowering effect is comparable with that of liraglutide, a commercial GLP-1 receptor agonist, in blood glycemic control but is better than that of metformin, a widely used first-line anti-diabetic drug, in this overt diabetic model. Collectively, I have identified for the first time, as to the best of our knowledge, that EA could be a dual-action compound that exerts anti-diabetic effects via activation of the GLP-1 mediated metabolic pathway and suppression of hepatic gluconeogenesis, leading to effective control on food intake, body weight gain, and glycemia in T2D mice.
Mullarky, Edouard. "Identification of Small Molecule Inhibitors of 3-Phosphoglycerate Dehydrogenase to Target Serine Biosynthesis in Cancers." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:26718745.
Повний текст джерелаMedical Sciences
Shaw, Joseph Charles. "Identification and characterisation of small molecule inhibitors targeted to the hepatitis C virus NS2 autoprotease." Thesis, University of Leeds, 2014. http://etheses.whiterose.ac.uk/8050/.
Повний текст джерелаLudwig, Marcus [Verfasser], Sebastian [Gutachter] Böcker, Juho [Gutachter] Rousu, and Nicola [Gutachter] Zamboni. "Bayesian methods for small molecule identification / Marcus Ludwig ; Gutachter: Sebastian Böcker, Juho Rousu, Nicola Zamboni." Jena : Friedrich-Schiller-Universität Jena, 2020. http://d-nb.info/1214296378/34.
Повний текст джерелаZelaya, Rainel. "Identification of Small Molecules that Inhibit Prostate Cancer Cell Proliferation." Honors in the Major Thesis, University of Central Florida, 2014. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1659.
Повний текст джерелаB.S.
Bachelors
Biomedical Sciences
Biomedical Sciences
GIOVANNINI, DANIELA. "Identification of putative small non coding RNAs in mycobacterium tuberculosis." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/208815.
Повний текст джерелаMycobacterium tuberculosis, the causative agent of tuberculosis, is one of the world‘s most successful pathogens. Post-transcriptional regulation of gene expression by small non-coding RNA molecules (sRNAs) has been demonstrated in a wide range of pathogenic bacteria and has been shown to play a significant role in the control of virulence. By a bioinformatics screening of intergenic region in M. tuberculosis we identified 3 novel sRNAs in the virulent M. tuberculosis H37Rv strain, named 1B, 5 and 12B. Using a BLAST search we also showed that all the three sRNAs are present in the MTB-Complex mycobacteria, being 1B MTB_Complex-specific, while 5 and 12B sRNAs are present also in M.bovis-Bacillus Calmette-Guérin (BCG), both Pasteur and Japan strains. We showed that the 1B, 5 and 12B sRNAs display differential expression pattern between synthetic medium culture and human macrophages infection, both in vitro and ex vivo. Of note, 1B and 5 sRNAs genes are significantly induced in Broncho alveolar lavage specimens collected from patients with active pulmonary tuberculosis. Interestingly, the 5 and 12B sRNAs displayed differential expression between M. tuberculosis and both the BCG Aventis and Pasteur strains in synthetic medium culture. Moreover, these three novel sRNAs show complementarities to several M. tuberculosis genes, suggesting the potential to act as trans-encoded sRNAs. Our study suggests that the 1B and 5 sRNAs genes likely play an important role within the network that regulates bacterial adaptation to environmental changes and stress conditions and thus might well contribute to control the pathogen virulence.
Zhao, Xiaoning. "Identification and characterization of a homophilic binding and neuritogenic site in the cell adhesion molecule L1." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ35382.pdf.
Повний текст джерелаZebedee, Zoë Anna-Marie. "Identification of scFv reagents which recognise the human neural cell adhesion molecule expressed upon neuroblastoma cells." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390796.
Повний текст джерелаHuerta, Uribe Alejandro. "Identification and characterisation of small-molecule inhibitors of Shiga toxin expression in Escherichia coli O157:H7." Thesis, University of Glasgow, 2019. http://theses.gla.ac.uk/40993/.
Повний текст джерелаJegede, Oyebisi. "Identification and Characterization of Novel Antiretroviral Compounds: from Small Molecule Library Screening to Rationally Designed Compounds." [Kent, Ohio] : Kent State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1185563176.
Повний текст джерелаTitle from PDF t.p. (viewed Mar. 11, 2009). Advisor: Miguel Quiñones-Mateu. Keywords: HIV/AIDS, drug discovery, small molecule library screening, characterization of new antiretroviral drugs, highly active antiretroviral therapy. Includes bibliographical references (p. 180-200).
McGregor, Lynn Marie. "Methods for the Identification of Ligand-Target Pairs from Combined Libraries of Targes and Ligands." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11370.
Повний текст джерелаRobke, Lucas [Verfasser], Herbert [Akademischer Betreuer] Waldmann, and Martin [Gutachter] Engelhard. "Discovery and target identification of small molecule autophagy inhibitors / Lucas Robke ; Gutachter: Martin Engelhard ; Betreuer: Herbert Waldmann." Dortmund : Universitätsbibliothek Dortmund, 2017. http://d-nb.info/1139892592/34.
Повний текст джерелаRichter, Melanie. "Identification and characterization of intracellular binding partners of the CHL1 (close homologue of L1) neural cell recognition molecule." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964447665.
Повний текст джерелаMonaghan, Amy Elizabeth. "The amino terminal domain of steroid hormone receptors as a novel drug target : identification of small molecule inhibitors." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230709.
Повний текст джерелаRooke, Kelly. "Identification of chromatin modifying mechanisms in inflammatory macrophages in rheumatoid arthritis." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:e39a5b64-a72c-4bd9-ab4d-957e9b2afc53.
Повний текст джерелаLaw, Yuen-kwan, and 羅婉君. "Study on the identification of small molecule activators of the autophagic pathway and elucidation of the mechanism of action." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42841793.
Повний текст джерелаLee, Po-Tsang. "Identification and characterisation of toll-like receptors (TLRs) and the TLR accessory molecule UNC93B1 in Atlantic salmon (Salmo salar)." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=226894.
Повний текст джерелаLaw, Yuen-kwan. "Study on the identification of small molecule activators of the autophagic pathway and elucidation of the mechanism of action." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42841793.
Повний текст джерелаPellattiero, Anna. "Pharmacological modulation of mitochondrial dynamics: identification of a specific OPA1 inhibitor to enhance apoptotic release of cytochrome c." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3426718.
Повний текст джерелаOstermann, Georg. "Identification of junctional adhesion molecule (JAM)-1 as a novel immunoglobulin superfamily ligand for lymphocyte function-associated antigen (LFA)-1." Diss., lmu, 2002. http://nbn-resolving.de/urn:nbn:de:bvb:19-6768.
Повний текст джерелаAl-Obaidi, Naowras [Verfasser]. "Target Identification of a Small Molecule Rescuing Monastrol-Induced Spindle Defects : Can Lipid Metabolism Govern Cytoskeletal Architecture? / Naowras Al-Obaidi." Konstanz : Bibliothek der Universität Konstanz, 2016. http://d-nb.info/1162443804/34.
Повний текст джерелаSaindon, Andrée-Anne. "Caractérisation des isoformes de la protéine SPAM1 (Sperm Adhesion Molecule 1) et identification de ses partenaires d'interactions dans les spermatozoïdes." Master's thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/27978.
Повний текст джерелаSperm Adhesion Molecule 1 (SPAM1) is a sperm protein that has a hyaluronidase activity in its N-terminus, aiding in the dispersal of the cumulus cells surrounding the egg. It also has a zona pellucida (ZP) binding activity in its C-terminus. Our previous studies showed that there are two potential SPAM1 isoforms that have a molecular weight of ~70 and 80 kDa in the bovine species. From these studies, we hypothesized that these two SPAM1 isoforms had different C-terminal domains, different origins (testis or epididymis) and were localised in the acrosomal or post-acrosomal regions of spermatozoa. Seeing as it is the C-terminal domain that is involved in ZP binding, we aimed to characterize the two C-terminal domains in order to better understand SPAM1’s role in gamete interactions. Although the 3’ nucleotide sequences were identical, two Spam1 transcripts varying by the presence or absence of 90 nucleotides (exon 3 of the Spam1 gene) were found in both testicular and epididymal tissues. During our studies, we also identified PH-20, a potential SPAM1 homolog. In order to determine if PH-20 is one of the two potential SPAM1 isoforms that is recognized by our antibody directed against the N-terminal domain, we attempted the production of a PH-20 recombinant protein, without success. We also sought to determine if SPAM1 is part of a multimeric protein complex involved in spermatozoa-ZP interactions, as reported in humans. Our results suggest that SPAM1 is associated with AKAPs, which are anchoring proteins abundantly found in the fibrous sheath of sperm flagella. Characterizing the SPAM1 isoforms, its homolog PH-20, as well as the multimeric protein complexes SPAM1 is part of, are important in order to better understand SPAM1’s role in gamete interactions.
Abdalla, Sarah. "Identification of the Regions in Factor V Mediating its Edocytosis by Megakaryocytes to Form the Unique Platelet-Derived Cofactor Molecule." ScholarWorks @ UVM, 2013. http://scholarworks.uvm.edu/graddis/6.
Повний текст джерелаBodle, Christopher Ralph. "Identification of small molecule inhibitors of regulator of G protein signaling proteins for pretherapeutic development for treatment of multiple pathologies." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5420.
Повний текст джерелаDE, FLORIAN FANIA ROSSELLA. "Identification and characterization of therapeutic molecules affecting expression levels of the tumor suppressor DAB2IP in cancer." Doctoral thesis, Università degli Studi di Trieste, 2023. https://hdl.handle.net/11368/3042421.
Повний текст джерелаIn tumors, the reciprocal communication between malignant cells and non-transformed stromal cells involves a variety of signaling proteins and modulators that cooperate to control proliferation, migration and apoptosis. Among them, the tumor suppressor DAB2IP, a Ras-GAP and signaling adaptor protein, modulates signal transduction in response to several extracellular stimuli, negatively regulating multiple oncogenic pathways. Accordingly, the loss of DAB2IP in tumor cells fosters metastasis and enhances chemo- and radio-resistance. DAB2IP is rarely mutated in cancer but is frequently downregulated or inactivated by multiple mechanisms. Solid experimental evidences indicate that DAB2IP reactivation can reduce cancer aggressiveness in tumors driven by multiple different oncogenic mutations. In this regard, we showed that the ectopic overexpression of DAB2IP is sufficient to significantly affect the behavior of prostate cancer cells, possibly slowing tumor dissemination. All these evidences indicate DAB2IP as a strong target for anti-cancer therapy. Nevertheless, therapeutic approaches to increase DAB2IP function in cancer are still not available. Based on these observations, we performed a high-throughput screening with more than 1200 FDA- approved drugs to search for molecules that increase DAB2IP protein levels. Since detection of endogenous DAB2IP is technically difficult due to relatively low expression levels and the limitations of available antibodies, we exploited CRISPR/Cas9 gene editing to generate two prostate cancer cell models expressing endogenous DAB2IP fused to HiBiT, a peptide tag that enabled luminescence- based detection of protein levels in a sensitive and quantitative manner. Using this approach, we identified a set of candidate drugs able to increase DAB2IP levels. We focused our attention on the three more effective drugs: one antibacterial, one antileukemic and one antiasthmatic. Although not conclusive, functional experiments indicate that DAB2IP-upregulating drugs can inhibit some cancer-associated phenotypes, and that some of these effects are at least in part dependent on DAB2IP. These findings, if further confirmed, may suggest a potential repurposing of these drugs for solid cancers’ treatment, as support to current therapies.
Wobst, Hilke [Verfasser]. "Identification of novel cytosolic binding partners of the neural cell adhesion molecule NCAM and functional analysis of these interactions / Hilke Wobst." Bonn : Universitäts- und Landesbibliothek Bonn, 2014. http://d-nb.info/1077289030/34.
Повний текст джерелаKondo, Yasushi. "Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells." Kyoto University, 2018. http://hdl.handle.net/2433/230976.
Повний текст джерела