Дисертації з теми "Molecule drug delivery"
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Moonschi, Faruk H. "APPLICATIONS OF CELL-DERIVED VESICLES: FROM SINGLE MOLECULE STUDIES TO DRUG DELIVERY." UKnowledge, 2018. https://uknowledge.uky.edu/chemistry_etds/98.
Повний текст джерелаLofton, Megan Christina. "Development of a small molecule drug delivery vehicle for treatment of chronic pulmonary diseases." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24706.
Повний текст джерелаFeil, Florian, Anna Sauer, Jens Michaelis, Thomas Bein, and Christoph Bräuchle. "Single molecule diffusion studies of mesoporous materials: from material science to drug-delivery applications." Diffusion fundamentals 16 (2011) 28, S. 1-2, 2011. https://ul.qucosa.de/id/qucosa%3A13761.
Повний текст джерелаCrawford, Robert. "Single-molecule DNA sensors and cages for transcription factors in vitro and in vivo." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:dc51a40b-4236-48ad-850e-e7e0010a823c.
Повний текст джерелаBrumaru, Claudiu Stelian. "I. Hydrophobic nanoporous silica particles for biomedical applications. II. Novel approaches to two-dimensional correlation spectroscopy." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/2446.
Повний текст джерелаWang, Xiaoyang. "Design, Construction and Investigation of Synthetic Devices for Biological Systems." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1314041031.
Повний текст джерелаDeosarkar, Sudhir P. "Development of Novel Therapeutic and Diagnostic Approaches for Atherosclerosis." Ohio University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1268371885.
Повний текст джерелаDcona, Martin. "Drug Delivery Strategies Using Light Sensitive Molecules." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/445.
Повний текст джерелаPan, Xiaogang. "Design and evaluation of lipid based delivery systems for delivery of small molecules and macro-molecular nucleotides based therapeutic agents." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164679618.
Повний текст джерелаCleroux, Carolyne. "Biodegradable nanoparticles for sustained occular drug delivery." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28485.
Повний текст джерелаTwyman, Lance James. "The synthesis and applications of dentrimeric molecules." Thesis, University of Kent, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259718.
Повний текст джерелаPavurala, Naresh. "Oral Drug Delivery -- Molecular Design and Transport Modeling." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/53505.
Повний текст джерелаPh. D.
Mitra, Deboleena. "Light Mediated Drug Delivery Using Photocaged Molecules and Photoswitchable Peptides." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3618.
Повний текст джерелаWahab, Habibah Bin. "Effect of a penetration enhancer on lipid membranes : a molecular dynamics study." Thesis, King's College London (University of London), 1999. https://kclpure.kcl.ac.uk/portal/en/theses/effect-of-a-penetration-enhancer-on-lipid-membranes--a-molecular-dynamics-study(15d6388d-136f-4763-90d1-71ff975b6869).html.
Повний текст джерелаComenge, Farre Joan. "Gold Nanoparticles as Drug Delivery Agents. Detoxifying the Chemotherapeutic Drug Cisplatin." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/125963.
Повний текст джерелаThe use of nanoparticles (NPs) has emerged as a potential tool to improve cancer treatment. Among the proposed uses in imaging and therapy, their use as a drug delivery scaffold has been extensively highlighted. However, there are still some controversial points which need a deeper understanding before applying them in the clinics. Here, it is presented the use of gold nanoparticles (AuNPs) to detoxify the antitumoral agent cisplatin linked to the nanoparticle via a pH sensitive coordination bond for endosomal release. Since size of NPs plays an important role in determining biological responses such as biodistribution or clearance by immune system, a perfect control on the synthesis of AuNPs is required previously to any biological application of these AuNPs. It is described in this work a new synthetic protocol of biocompatible AuNPs with a perfect control of the size between 5 to 200 nm. One of the advantages of this protocol is the obtaining of citrate-capped AuNPs that can be further functionalized. This allowed us to provide insights on the mechanism of Self-Assembled Monolayers and mixed layers formation. The control of the mixed layer composition and conformation is important since it determines biological outcomes such as protein adsorption and colloidal stability in physiological media. These AuNPs conjugates are used as scaffold for cisplatin attachment via the formation of a coordination bond that ensures a pH-triggered release of the drug. This conjugation is deeply characterized to ensure the maintenance of colloidal and link stability on working conditions. Finally, the NP conjugate design has important effects on pharmacokinetics, conjugate evolution and biodistribution and absence of observed toxicity. Here we show that cisplatin-induced toxicity is clearly reduced without affecting the therapeutic benefits in mice models. The NPs not only act as carriers, but also protect the drug from deactivation by plasma proteins until conjugates are internalised in cells and cisplatin released. Also, the possibility to track the drug (Pt) and the vehicle (Au) separately as a function of organ and time enables a better understanding of how nanocarriers are processed by the organism.
Zhang, Mengzi. "DEVELOPMENTS OF LIPID-BASED NANOPARTICLES FOR THERAPEUTIC DRUG DELIVERY." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417025932.
Повний текст джерелаWeight, Alisha K. (Alisha Kessel). "Enhancing pharmaceutical formulations to improve efficacy and delivery of drug molecules." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/82323.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references.
Major impediments to the full utility of current and potential drugs include issues of resistance and delivery. To address these challenges, in this thesis two directions of research were pursued: (1) the use of multivalent polymeric inhibitors to overcome drug resistance in human and avian influenza and (2) low-viscosity, high-concentration protein suspensions for therapeutic antibody, in particular monoclonal antibody (MAb), delivery. (1) Influenza resistance to small molecule neuraminidase (NA) inhibitors is spreading. Little emphasis, however, has been placed on alternative formulations of inhibitors. We investigated the design of multivalent antivirals, wherein small molecule ligands of viral proteins are conjugated via a linker to a linear polymeric backbone. Unexpectedly, we found that a poly-L-glutamine bearing pendant zanamivir (ZA) groups is at least as potent as those containing both ZA and sialic acid (SA). By examining the structure-activity relationship of such monofunctional conjugates, we show that the most potent one has 10% ZA attached to a neutral, high molecular weight backbone through a short alkyl linker. Importantly, we also demonstrate that such a polymer conjugate entirely compensates for weakened binding in and has 2,000-fold enhanced anti-viral potency against, ZA-resistant strains. We further evaluated this optimized inhibitor in vivo and observed that it is an effective therapeutic of established infection in ferrets and reduces viral titers up to 190-fold when used as a combined prophylactic/therapeutic in mice. Additionally, we see no evidence that the conjugate stimulates an immune response in mice upon repeat administration. (2) Typically, high doses of MAb therapeutics are required for clinical effect. Ideally, these MAbs would be delivered by subcutaneous injection of a small liquid volume. Such highly concentrated MAb solutions, however, are far more viscous than the 50 centipose (cP) permitted by the FDA. We evaluated approaches to reduce formulation viscosity by forming protein suspensions. Aqueous suspensions induced by poly(ethylene glycol), precipitating salts, or ethanol actually increased viscosity. However, non-aqueous suspensions of amorphous antibody powders in organic solvents that have s 1 hydrogen atom available for hydrogen-bonding, exhibited up to a 38-fold decrease in viscosity.
by Alisha K. Weight.
Ph.D.in Biological Chemistry
Skilling, Kathryn J. "Low molecular mass nucleoside gelators for intra-tumoural drug delivery." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33222/.
Повний текст джерелаRay, Judith Victoria. "Novel molecular imprinted nanogels as drug delivery vehicles for tamoxifen." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8856.
Повний текст джерелаWong, Ling Wai. "Molecular delivery system based on the nanoporous zeolite microstructures /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?BIEN%202006%20WONG.
Повний текст джерелаTeng, Yue. "Solubilization and release studies of small molecules in polymeric micelles /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.
Повний текст джерелаSakhalkar, Harshad S. "Enhanced Adhension of Biodegradable Drug Delivery Vehicles to Inflamed Endothelium." Ohio University / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1129916752.
Повний текст джерелаWood, Kris Cameron. "Nanostructured gene and drug delivery systems based on molecular self-assembly." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39350.
Повний текст джерелаIncludes bibliographical references.
Molecular self-assembly describes the assembly of molecular components into complex, supramolecular structures governed by weak, non-covalent interactions. In recent years, molecular self-assembly has been used extensively as a means of creating materials and devices with well-controlled, nanometer-scale architectural features. In this thesis, molecular self-assembly is used as a tool for the fabrication of both gene and drug delivery systems which, by virtue of their well-controlled architectural features, possess advantageous properties relative to traditional materials used in these applications. The first part of this thesis describes the solution-phase self-assembly of a new family of linear-dendritic "hybrid" polymers with plasmid DNA for applications in gene therapy. It begins with an overview of the design of next-generation, non-viral gene delivery systems and continues through the synthesis and validation of hybrid polymer systems, which possess modular functionalities for DNA binding, endosomal escape, steric stabilization, and tissue targeting. This part of the thesis concludes with applications of these systems to two areas of clinical interest: DNA vaccination and tumor targeted gene therapy.
(cont.) The second part of this thesis describes the directed self-assembly of polymeric thin films which are capable of degrading in response to either passive or active stimuli to release their contents. It begins with a description of passive release thin films which degrade by basic hydrolysis to release precise quantities of model drug compounds. These systems can be engineered to release their contents on time scales ranging from hours to weeks and can also be designed to release multiple drugs either in series or in parallel. Later, field-activated thin films which release their contents in response to an external, electrical stimulus are described and characterized in detail. Together, these approaches combine rapid and inexpensive processing, the ability to conformally coat any surface regardless of composition, size, or shape, and the ability to release multi-drug or multi-dose schedules, and as such they may find applications in a range of areas.
by Kris Cameron Wood.
Ph.D.
Angelos, Sarah Ann. "Molecular machines supported on mesoporous silica nanoparticles for drug delivery applications." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1835827851&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Повний текст джерелаHashmi, Sumaiya F. "A DNA Computer for Glioblastoma Multiforme Diagnosis and Drug Delivery." Scholarship @ Claremont, 2013. http://scholarship.claremont.edu/cmc_theses/799.
Повний текст джерелаArmishaw, Olga Anne. "Molecular studies of organometallic carbohydrates and related compounds." Thesis, Robert Gordon University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360997.
Повний текст джерелаSaito, Takashi. "DESIGN AND CHARACTERIZATION OF GELATIN HYDROGELS INCORPORATING LOW-MOLECULAR-WEIGHT DRUGS FOR TISSUE REGENERATION." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/199334.
Повний текст джерелаAli, Maryam Byrne Mark E. "Therapeutic contact lenses for comfort molecules." Auburn, Ala., 2007. http://hdl.handle.net/10415/1334.
Повний текст джерелаGerayeli, Faezeh. "Stimulated delivery of therapeutic molecules from hydrogels using ultrasound." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAS019/document.
Повний текст джерелаThe research described in this thesis is directed to study an externally stimulated DDS that incorporates a hydrogel as the matrix for the therapeutic agent. The research does not investigate a particular site for the delivery of the therapeutic agent. However, the aim of this research program is to develop various hydrogel formulations with desirable characteristics and structures from which the drug release can be controlled with applied external energy in the form of low-frequency ultrasound. To accomplish this, two types of natural hydrogels from agarose and chitosan and one type of synthetic hydrogel from PVA were fabricated. Parameters that affect the structure were varied for each type of hydrogel in order to study the effect of structural changes on drug loading and release capacity of hydrogels. Next, the obtained hydrogels were assessed for the delivery of Theophylline as the model drug.Among the three types of hydrogels, chitosan was found to have the fastest swelling rates and the higher water uptakes while the least swelling was found with PVA hydrogels and then agarose hydrogels crosslinked at pH 12. Regarding the mechanical stability of hydrogels, the ranking of the elastic modulus was PVA hydrogels (highest), then agarose hydrogels and chitosan copolymers (lowest). It seemed that the more mechanically stable structure of the PVA hydrogels correlated with a reduced mobility of water, in comparison to the greater mobility of water in the mechanically weaker chitosan copolymers.The stimulated and passive release of Theophylline from those hydrogel carriers showed how ultrasound, as an external energy, stimulates and controls the release of the drug. The measurements confirmed that it is only the energy imparted by the longitudinal ultrasonic waves that act on the polymeric network. The mechanism by which the ultrasound affects the release is considered as a form of a ratchet motor. The polymer chains play the role of the “ratchet” steps and the ultrasonic waves accelerate the particle movement in the release media. Hence, once the ultrasound is applied, the particles descend chain-to-chain (i.e. step-by-step) driven down their concentration gradient by the applied energy until they reach the surface of the hydrogel and hence are released into the surrounding media.Increasing the ultrasound intensity vastly accelerates the drug release. Indeed a higher intensity equals a higher energy transferred from the ultrasonic waves to the drug particles, resulting in faster and less controlled release. This also depends on the type of drug carrier structure. If the hydrogel carrier is mechanically stable, such as the PVA samples or the agarose hydrogels crosslinked at pH 12, the effect of high ultrasound intensity is much less compared to a less mechanically stable carrier such as the chitosan blends. Ultrasound applied for a longer period of time increases the amount of drug released, with the consequent effect of increasing the amount of heat generated in the hydrogel. Generally, a longer duration of the applied energy results in a greater amount of energy absorption, and an increase in friction and heat generation. These effects are important considerations in relation to the heat sensitivity of the drug to be delivered and the thermal characteristics of the polymeric carrier.This PhD research has demonstrated that both natural and synthetic hydrogels coupled to an ultrasonic energy source provides a controllable DDS, which provide some novel outcomes and contributions to the body of knowledge in the field of controlled drug delivery
Zhang, Ning. "Design of high molecular weight polymerized hemoglobins for use in transfusion medicine and monocyte/macrophage hemoglobin-based drug delivery systems." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1318952866.
Повний текст джерелаSodha, Anirudhasingh. "DEVELOPMENT AND COMMERCIALIZATION OF HEPATOCYTE TARGETED DRUG DELIVERY VEHICLE FOR PHARMACEUTICAL APPLICATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1247192896.
Повний текст джерелаLeves, Natalia. "Nanopartículas de grafite para carreamento de antiinflamatórios não esteroidais por estudos de docking molecular." Universidade Federal de São Carlos, 2013. https://repositorio.ufscar.br/handle/ufscar/7035.
Повний текст джерелаThe non steroidal anti-inflammatory drugs have been known for over 100 years and has been widely used by mankind. However cause adverse effects, since gastrointestinal complications to cardiac diseases many of these symptoms related to its nonspecific action in biological systems. Thus, the proposal of a drug delivery system for loading these drugs to the site of inflammation, could reduce these unwanted effects in the body due to the limitation of more targeted effects beyond its site of action.In this study, the graphene and graphite plates were used as carriers, since studies demonstrate the usefulness of other conformational structures of carbon as drug carriers for the treatment of cancer, for example. Two models were studied for the plates by softwares of molecular docking: template sandwich, which comprises two carbon plates, with ligant between them, and the model surfing with one carbon plate comprising the ligant. The compounds were obtained from data banks, such as CSD, PDB and SD, the plates were obtained by molecular modeling. The analysis of intermolecular interactions, essential knowledge for understanding the structures obtained was done using molecular imaging with high resolution. The experimental results showed that the in silico model sandwich was the most favorable for this system, providing stability and protection for the ligand that this does not become detached from the plates during the path taken in the body to the desired location.
Os anti-inflamatórios não esteroidais são conhecidos há mais de 100 anos e vem sendo amplamente utilizados pela humanidade. No entanto, causam efeitos adversos, desde problemas gastrointestinais até complicações cardíacas, muitos desses sintomas relacionados com sua ação inespecífica nos sistemas biológicos. Dessa forma, a proposta de um sistema de drug delivery para o carreamento desses fármacos até o local da inflamação, poderia reduzir esses efeitos indesejados no organismo devido a limitação de alvos mais específicos além do seu local de ação. No presente estudo, foram utilizadas placas de grafeno e grafite como carreadores, uma vez que estudos demonstram a utilidade de outras estruturas conformacionais do carbono como carreadores de fármaco para o tratamento de câncer, por exemplo. Foram estudados dois modelos para as placas por meio de software de docking molecular: modelo sandwich, o qual engloba duas placas de carbono, com os ligantes entre elas, e o modelo surf, com uma placa de carbono comportando o ligante. Os compostos estudados foram obtidos dos bancos de dados como CSD, SD e PDB e as placas foram obtidas por modelagem molecular. A análise das interações intermoleculares, conhecimento essencial para o entendimento das estruturas obtidas, foi feita utilizando visualização molecular de alta resolução. Os resultados dos experimentos in silico mostraram que o modelo sandwich foi o mais favorável para esse sistema, posto que confere estabilidade e proteção ao ligante para que este não se desprenda das placas durante o caminho percorrido pelo organismo até o local desejado.
De, la Torre Paredes Cristina. "Nanotechnology and supramolecular chemistry in controlled release and molecular recognition proceses for biomedical applications"." Doctoral thesis, Universitat Politècnica de València, 2018. http://hdl.handle.net/10251/94043.
Повний текст джерелаThis PhD thesis entitled "Nanotechnology and supramolecular chemistry in controlled release and molecular recognition processes for biomedical applications", is focused on two important subjects: molecular recognition and controlled delivery processes. This PhD thesis is structured in four chapters. The first chapter introduces the concept of organic-inorganic hybrid materials containing switchable "gate-like" ensembles and their biomedical applications as nanomaterials for targeting and control drug delivery. Furthermore, is introduced a short review about chromo-fluorogenic chemosensors based on basic principles of supramolecular chemistry, particulary in molecular recognition processes. In particular, in chapter 2 is focus on the development of enzymatic-driven nanodevices. These hybrid materials are composed of two main units: an inorganic silica based mesoporous scaffold, able to store organic molecules and an organic compound anchored on the external surface of the inorganic mesoporous support than acts as molecular gate. All the systems proposed use peptidic gates that respond to temperature or enzimatic stimulis. The second part of this PhD thesis is focused on the design and development of a new chemical compound capable of detecting carbon monoxide in vivo. In summary, for all the results above mentioned we can say that this PhD thesis constitutes an original scientific contribution to the development of supramolecular chemistry. Its results derived from the studies presented leaves open routes to continue the study and development of new hybrid materials and more efficient chemical sensors with biomedical and therapeutic applications.
La present tesi doctoral, titulada "Nanotecnologia i química supramolecular en processos d'alliberament controlat i reconeixement molecular per a aplicacions biomèdiques", es centra en dos temes importants de la química: el reconeixement molecular i els processos d'alliberament controlat. Aquesta tesi doctoral està estructurada en quatre capítols. El primer capítol introdueix el concepte de materials híbrids orgànics-inorgànics funcionalitzats amb portes moleculars i les seves aplicacions biomèdiques com nanomaterials per dirigir i controlar l'alliberament controlat de fàrmacs. A més s'introdueix una breu descripció sobre sensors colorimètrics fonamentats en la base de la química supramolecular, particularment en els processos de reconeixement molecular. En particular, el capítol 2 descriu la preparació de cinc nanodispositius que responen a enzims. Aquests materials híbrids es componen de dues unitats principals: un suport mesoporos basat en sílice inorgànica, capaç d'encapsular molècules orgàniques i un compost orgànic ancorat a la superfície externa del suport mesoporós inorgànic que actua com a porta molecular. La segona part d'aquesta tesi doctoral es centra en el disseny i desenvolupaent d'un nou compost químic capaç de detectar monòxid de carboni in vivo. En resum, per a tots els resultats abans mencionats podem dir que esta tesi doctoral constituïx una contribució científica original al desenvolupament de la química supramolecular. Els seus resultats derivats dels estudis presentats deixen rutes obertes per a continuar l'estudi i el desenvolupament de nous materials hibrids i sensors químics més eficients per a aplicacions biomèdiques i terapeutiques.
De La Torre Paredes, C. (2017). Nanotechnology and supramolecular chemistry in controlled release and molecular recognition proceses for biomedical applications" [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/94043
TESIS
Dennis, Andrew C. "Studies of some molecular reorganisations in the solid state and in colloidal media by vibrational spectroscopy." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322846.
Повний текст джерелаKwok, Connie Sau-Kuen. "Development of self-assembled molecular structures on polymeric surfaces and their applications as ultrasonically responsive barrier coatings for on-demand, pulsatile drug delivery /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/7999.
Повний текст джерелаZhou, Chenguang. "NANOCARRIERS FOR THERAPEUTIC NUCLEIC ACID DELIVERY." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1336584204.
Повний текст джерелаChen, Po Chih. "Design and synthesis of small molecules and nanoparticle conjugates for cell type-selective delivery." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/28111.
Повний текст джерелаCommittee Chair: Oyelere, Adegboyega; Committee Member: Bunz, Uwe; Committee Member: Collard, David; Committee Member: Lobachev, Kirill; Committee Member: Tolbert, Laren.
Gade, Terence Peter Ferrante. "Integrated imaging of drug delivery : a molecular imaging approach to the optimization of cancer therapy /." Access full-text from WCMC:, 2007. http://proquest.umi.com/pqdweb?did=1432803381&sid=12&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Повний текст джерелаHernández, Teruel Adrián. "Smart drug delivery systems designed to improve Inflammatory Bowel Disease therapy." Doctoral thesis, Universitat Politècnica de València, 2019. http://hdl.handle.net/10251/129863.
Повний текст джерела[CAT] La present tesi doctoral titulada "Sistemes d'alliberament controlat de farmacs dissenyats per a millorar el tractament de Malaltia Inflamatoria Intestinal" se centra en el disseny, preparacio, caracteritzacio i avaluacio in vivo de diferents sistemes d'alliberament controlat de farmacs en colon (*CDDS, per les seues sigles en angles) utilitzant com a suport microparticules de si'lice mesoporosa, funcionalitzades amb portes moleculars. En conclusio, els estudis realitzats demostren que els materials de si'lice mesoporosa, en combinacio amb portes moleculars sensibles a estimuls especifics, tenen un gran potencial per al desenvolupament de nous sistemes d'alliberament controlat de farmacs en el colon, dirigits a millorar l'arsenal terapeutic disponible per al tractament de MII. La possibilitat d'adaptar o personalitzar la carrega i les portes moleculars, fa que aquests suports de silice mesoporosa siguen una opcio interessant per al desenvolupament de nous sistemes d'alliberacio controlada de farmacs en diferents aplicacions biomediques. Finalment, esperem que els resultats obtinguts en aquesta tesi doctoral servisquen d'inspiracio per al desenvolupament de sistemes d'alliberament controlat de farmacs innovadors i cada vegada mes intel·ligents, per a la seua aplicacio tant en medicina com en altres arees.
[EN] This PhD thesis entitled "Smart drug delivery systems designed to improve Inflammatory Bowel Disease therapy" is focused on the design, synthesis, characterization and in vivo evaluation of several Colon Drug Delivery Systems (CDDS) using hybrid mesoporous silica microparticles as scaffolds containing molecular gates. In conclusion, the studies shown in this Thesis demonstrate that mesoporous silica materials in combination with responsive molecular gates have great potential in the design and preparation of new CDDS to improve the therapeutic options available for IBD. The possibility to adapt the cargo and the molecular gate makes mesoporous silica support especially appealing for similar controlled drug delivery applications in the biomedical field. We hope that the obtained results could inspire the development of new innovative smart drug delivery systems in this or other fields.
We thank the Spanish Government (projects MAT2015-64139-C4-1-R and AGL2015-70235-C2-2-R (MINECO/FEDER)) and the Generalitat Valenciana (project PROMETEOII/2014/047) for support. AHT thanks to the Spanish MEC for his FPU grant. We thank the Generalitat Valenciana (Project PROMETEO2018/024)
Hernández Teruel, A. (2019). Smart drug delivery systems designed to improve Inflammatory Bowel Disease therapy [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/129863
TESIS
Kaur, Davinder. "Investigation of cellular and molecular mechanisms involved in targeted drug delivery systems for human cancers." Thesis, University of Leicester, 2002. http://hdl.handle.net/2381/29670.
Повний текст джерелаClergeaud, Veiga Gael. "Liposomes as versatile tools: nanoreactors, membrane models and drug delivery carriers." Doctoral thesis, Universitat Rovira i Virgili, 2014. http://hdl.handle.net/10803/285333.
Повний текст джерелаLas moléculas lipídicas pueden formar numerosas estructuras supramoleculares gracias a sus propiedades de auto ensamblaje en ambientes acuosos. Una de las estructuras más exploradas, los liposomas, son formados cuando bicapas laminares se curvan produciendo vesículas cerradas con un núcleo acuoso en el interior. Esta particular organización, la cual ofrece ambientes hidrófilos (en el núcleo) e hidrófobos (dentro de la membrana) para poder transportar moléculas polares y apolares, junto con su naturaleza biocompatible, biodegradable y no inmunogenica, hace que los liposomas sean una de las piezas claves en el ámbito de la nanobiotecnologia. En consecuencia, los liposomas han sido ampliamente establecidos como herramientas versátiles en un gran número de aplicaciones, incluyendo productos farmacéuticos, cosméticos, tecnología de los alimentos, como modelos de membranas biológicas, amplificadores de señal en ciencias analíticas, nanoreactores, herramientas de diagnóstico y un amplio etcétera. En este trabajo hemos demostrado el uso de liposomas como nanoreactores o plantillas para la síntesis de nanopartículas metálicas de forma y tamaño controlada. Además, los liposomas también se utilizaron como modelos de membrana que imitan la membrana plasmática de la célula para la determinación de la actividad ionófora de varios compuestos fenólicos dietéticos hacia el zinc. Por último, la capacidad de los liposomas para el transporte y entrega de medicamentos ha sido explorada con el fin de desarrollar el potencial de liposomas que son sensibles hacia la degradación específica por una enzima como vehículos de fármacos para la encapsulación de oxaliplatino para el tratamiento del cáncer de colon. En resumen, el trabajo presentado en esta tesis doctoral fortalece la visión de los liposomas como herramientas versátiles que pueden ser utilizadas en diferentes aplicaciones científicas.
Lipid molecules can form numerous supramolecular structures through their self-assembly properties displayed within aqueous environments. One of the most explored structures, the liposomes, are formed when lamellar bilayers bend into closed vesicles containing an aqueous core inside. This particular structural organization, offering hydrophilic (core) and hydrophobic (within the membrane) environments to carry both polar and non-polar molecules,as well as their biocompatible, biodegradable and non-immunogenic properties, make liposomes as one of the cornerstones of nanobiotechnology. Consequently, liposomes have been extensively established as versatile tools in a large number of applications including pharmaceutics, cosmetics, food technology, models as biological membranes, signal amplifiers in analytical sciences, nanoreactors, diagnosing tools and a wide so on. In summary, the work presented in this doctoral thesis strengthens the view of liposomes as versatile tools that can be used in many different scientific applications. Liposomes were exploited as nanoreactors or templates for the shape and size controlled synthesis of metal nanoparticles. Furthermore, liposomes were used as membrane models that mimic the cell plasma membrane for the determination of zinc ionophore activity of several dietary phenolic compounds. Ultimately, the ability of liposomes to carry and delivery drugs was explored in order to investigate the potential of enzyme-degradable liposomes as drug carriers for the encapsulation of oxaliplatin to effectively enhance its pharmacokinetics for the treatment of colon cancer. In summary, the work presented in this thesis strengthens the vision of liposomes as a versatile tool that can be used in different scientific applications.
Martini, Cecilia. "Idrotalciti Zn/Al intercalate con molecole biologicamente attive per il trattamento combinato di neoplasie." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14432/.
Повний текст джерелаBock, Nathalie. "Delivery of therapeutic molecules using electrosprayed polymeric particles for applications in tissue engineering." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/74514/1/Nathalie_Bock_Thesis.pdf.
Повний текст джерелаEing, Matthias. "Polymeric nanocarriers for the visualisation and quantification of molecular release." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/132683/1/Matthias_Eing_Thesis.pdf.
Повний текст джерелаOrellana, Bryan R. "BIOERODIBLE CALCIUM SULFATE BONE GRAFTING SUBSTITUTES WITH TAILORED DRUG DELIVERY CAPABILITIES." UKnowledge, 2014. http://uknowledge.uky.edu/cbme_etds/18.
Повний текст джерелаNagireddy, Bharat. "AN EFFECTIVE DRUG DELIVERY PROCESS USING A NOVEL CYLINDRICAL PARTICLE MODEL JUSTIFIED BY MOLECULAR DYNAMICS SIMULATION." University of Akron / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=akron1187105640.
Повний текст джерелаBareiss, Bettina. "Development of in vitro Models for Delivery of the Anti-Viral Drug Acyclovir for Ocular HSV-I Infection Treatment." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28542.
Повний текст джерелаAbdullah, Che Azurahanim Che. "Nanostructured materials as molecular transporters and cell growth substrates for drug delivery and tissue engineering applications." Thesis, University of Surrey, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548355.
Повний текст джерелаLlorens, Domenjó Elena. "Advanced electrospun scaffolds based on biodegradable polylactide and poly(butylene succinate) for controlled drug delivery and tissue engineering." Doctoral thesis, Universitat Politècnica de Catalunya, 2014. http://hdl.handle.net/10803/284662.
Повний текст джерелаLa técnica de 'electrospinning' o electrohilado es un proceso de fabricación que utiliza un campo eléctrico para producir fibras a partir de disoluciones de polímeros. La acumulación de estas fibras conforma una matriz tri-dimensional o 'scaffold', y las fibras pueden ser preparadas en escala micro y nanométrica. Además, estas matrices o 'scaffold' se caracterizan por su gran superficie por unidad de masa, estructura porosa y propiedades mecánicas influenciadas por la orientación de las fibras. El 'electrospinning' es muy versátil y un gran número de polímeros con diferentes propiedades pueden ser procesados. Sin embargo, un gran número de variables pueden influir en las características de las fibras obtenidas, siendo variables propias del polímero (p.e., solubilidad, peso molecular, etc.) o relacionadas a los parámetros del proceso (voltaje, flujo, distancia colector-aguja). Estas matrices de fibras son atractivas para aplicaciones biomédicas como la ingeniería de tejidos y sistemas de liberación controlada de fármacos. En el último caso, es importante la carga de diferentes fármacos o drogas para su administración directa y localizada en el cuerpo humano. El objetivo de esta Tesis es el estudio de diferentes matrices constituidas por nano o microfibras electrohiladas. El desarrollo de este estudio se divide en cuatro bloques. En el primer bloque, matrices de fibras de poliláctico (PLA) fueron cargadas con diferentes moléculas con actividad antioxidante (vitamina B6 en sus formas de piridoxina y piridoxal, ácido p-cumárico y ácido cafeico). Se determinó la influencia de estas moléculas sobre las propiedades físicas, morfología, liberación in vitro y biocompatibilidad de dichas matrices. Además, se demostró la aplicación de estos nuevos materiales en la inhibición del daño oxidativo del ADN causado por iniciadores de radicales libres, y en consecuencia, estas matrices serían útiles para la purificación de ADN plasmídico o genómico. En el segundo bloque, las matrices de PLA fueron cargadas con dos o tres fármacos para obtener matrices multifuncionales en base a sus actividades. Con esta finalidad, moléculas con actividad antioxidante, anti-inflamatoria, y antimicrobiana fueron cargadas en las matrices para evitar los procesos de oxidación de diferentes biomoléculas (proteínas, ADN, etc.), evitar la inflamación local, y reducir el riesgo potencial de infección microbiana de las heridas, respectivamente. Estas matrices son especialmente interesantes debido a las sinergias y antagonismos que pueden ocurrir durante su liberación simultánea. En el tercer bloque, se prepararon matrices biodegradables a partir de polímeros no-electrohilables. Estos polímeros pueden presentar características particulares, como actividad bactericida, o actividad conductora/electroactividad. Matrices hibridas conformadas con diferentes ratios de PLA usado como polímero biodegradable y el poli(3-tiofeno metil acetato) como polímero electroactivo fueron preparadas y evaluadas. También se prepararon matrices de nanofibras de PLA cargadas con clorhidrato de polihexametilenbiguanida (PHMB) obteniéndose matrices biodegradables con actividad antibacteriana, y la liberación del PHMB fue altamente dependiente de la hidrófilicidad del medio. Finalmente, en el cuarto bloque, se prepararon matrices electrohiladas usando un polímero de sacrificio (polietilenglicol o PEG) que puede ser eliminado fácilmente por solubilización en medios acuosos. Tres preparaciones diferentes fueron evaluadas: a) Matrices constituidas por diferentes proporciones de PLA y PEG en las fibras, b) Matrices constituidas por fibras de PLA y fibras de PEG y, c) Matrices constituidas por fibras coaxiales con diferentes distribuciones de polímeros en el núcleo y la corteza de la fibra. La colonización celular en todas estas matrices fue mejorada. Estos tres procedimientos permitieron obtener matrices con diferentes comportamientos para la liberación de fármacos.
Ramachandran, Niraj. "Corona Ion Deposition: A Novel Non-Contact Method for Drug and Gene Delivery to Living Systems." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002474.
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