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Книги з теми "Molecular selectivity"

Автор: Grafiati

Опубліковано: 21 грудня 2024

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1

Hathway, D. E. Molecular mechanisms of herbicide selectivity. Oxford: Clarendon, 1989.

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2

De Matteis, F., and E. A. Lock. Selectivity and Molecular Mechanisms of Toxicity. London: Palgrave Macmillan UK, 1987. http://dx.doi.org/10.1007/978-1-349-08759-4.

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3

A, Lock E., ed. Selectivity and molecular mechanisms of toxicity. Basingstoke: Macmillan, 1987.

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4

Sokell, Emma Jane. A study of decay route selectivity in atomic and molecular autoionisation using two-dimensional photoelectron spectroscopy. Manchester: University of Manchester, 1995.

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5

Crowe, Declan Brendan. Macrocyclic host molecules designed to selectively bind and transport ammonium and primary ammonium guest cations. Birmingham: University of Birmingham, 1991.

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6

Molecular mechanisms of herbicide selectivity. Oxford [England]: Oxford University Press, 1989.

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7

(Editor), E. A. Lock, ed. Selectivity and Molecular Mechanisms of Toxicity. Macmillan Pub Co, 1987.

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8

Matteis, Francesco De, and Edward A. Lock. Selectivity and Molecular Mechanisms of Toxicity. Palgrave Macmillan, 1987.

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9

Knaggs, Roger D. The molecular structure of the μ‎-opioid receptor. Редактори Paul Farquhar-Smith, Pierre Beaulieu та Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0038.

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Анотація:

The landmark paper discussed in this chapter describes the crystal structure of the μ‎-opioid receptor (also known as MOP-1). Opioids are some of the oldest known drugs and have been used for over 4,000 years; however, in addition to having beneficial analgesic effects, they are associated with a myriad of side effects that can minimize their use. Although the gene sequences of the opioid receptors were determined in the 1990s it has taken much longer to translate this into visualizing their three-dimensional structure. The μ‎-opioid receptor consists of seven transmembrane α‎-helices that are connected by three extracellular loops and three intracellular loops, with a wide open binding pocket which offers many potential ligand interaction sites, and evidence of dimerization. Understanding the crystal structure of the μ‎-opioid receptor in much more detail aids explanation of the molecular determinants of ligand recognition and selectivity and will be of use in designing novel opioids with improved efficacy and fewer side effects.

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10

Molecular dipoles in non-polar solvent: A mechanistic investigation of complexation phenomena and selectivity in asymmetric urea-super acid cocatalysis. 2010.

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11

Characterization of motor pool selectivity of neuromuscular degeneration and identification of molecular correlates of disease resistance in Type I spinal muscular atrophy. [New York, N.Y.?]: [publisher not identified], 2015.

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12

Josephs, Debra H., Heather J. Bax, Giulia Pellizzari, James F. Spicer, Ana Montes, and Sophia N. Karagiannis. Antibody Therapeutics for Ovarian Carcinoma and Translation to the Clinic. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190248208.003.0001.

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Despite improvements over the past decade in the treatment of ovarian cancer, many patients are at risk of recurrent disease and emerging drug resistance. The increased selectivity and reduced toxicity of molecularly targeted anti-cancer agents renders them attractive for development in ovarian cancer, and monoclonal antibodies targeting ovarian cancer-specific tumor antigens represent the largest such group investigated in this clinical setting. This chapter describes examples of monoclonal antibodies clinically evaluated for efficacy in ovarian cancer. These agents recognize molecular targets expressed on tumors or within tumor microenvironments that may be essential for tumor cell survival and proliferation. Recently, antibodies targeting checkpoint molecules on immune cells have shown efficacy in modulating anti-tumor immunity, and applications in ovarian carcinomas are evaluated. The chapter focuses on therapeutic agents’ attributes on targeting key cancer growth and progression pathways, and propensity to engender effector functions by activating immune effector cells in tumors and the circulation.

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13

Engel, Paul. Enzymes: A Very Short Introduction. Oxford University Press, 2020. http://dx.doi.org/10.1093/actrade/9780198824985.001.0001.

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Enzymes: A Very Short Introduction explores enzymes, the tiny molecular machines that make life possible. These proteins speed up chemical reactions inside a living organism many millionfold. Working together, teams of enzymes carry out all the processes that can be collectively recognized as life, from making DNA to digesting food. This VSI explains how this works, before going on to reveal how these catalysts of such extraordinary power and exquisite selectivity have evolved. It also examines the many varied ways in which individual enzymes are used nowadays as tools—in medical diagnosis and therapy, washing powders, food production, waste treatment, and chemical synthesis. New vistas have opened up through application of molecular genetics, not only allowing cheap, large-scale production of pure enzymes but also making possible new, tailor-made enzymes.

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14

Orrit, Michel. Single-molecule spectroscopy. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198768609.003.0006.

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This chapter gives an overview of the main optical methods used to detect and study single molecules and other small objects (nano-objects). Much of the work so far has exploited the excellent sensitivity and selectivity of fluorescence, but several new techniques, mostly based on nonlinear optics, have recently reached the single-molecule or single-nanoparticle regime. The chapter briefly discusses some results with reference to published reviews. Single-molecule techniques have now been incorporated into the arsenal of the physico-chemist and the cell biologist. However, the recent development of super-resolution techniques and of new labels suggests that further progress can be expected from measurements on single nano-objects in the next few years.

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15

Goodyer, Paul. Kidney/ear syndromes. Edited by Giuseppe Remuzzi. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0170.

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Malformations of the external ear may signal renal disease, but it is actually the disorders of the inner ear which reflect molecular pathways that are also crucial for kidney development. In a number of monogenic renal diseases, renal dysplasia is associated with deafness. Disorders of the kidney and inner ear are also linked in complex syndromes such as the human ciliopathies. In some cases, the loss of specific genes affects shared transport physiology, basement membrane assembly, or energy metabolism.The kidney and cochlea have a common susceptibility to toxins that are selectively concentrated by comparable uptake mechanisms in the two tissues.This chapter provides an overview of the many ways in which pathologies of the two organs are linked.

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