Дисертації з теми "Molecular investigations"
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Man, Yang Kee Stella. "Molecular investigations of familial paraganglioma." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408678.
Повний текст джерелаBell, Andrew John. "Spectroscopic investigations of molecular dynamics." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280858.
Повний текст джерелаMaughan, Juanita Amanda. "Molecular investigations of plant cytochrome P450." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388204.
Повний текст джерелаMacCarthy-Morrogh, Lucy. "Molecular investigations of BtK and WASP." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286330.
Повний текст джерелаTassell, M. J. "Computational investigations of molecular actinide chemistry." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1386659/.
Повний текст джерелаBlundell, M. P. "Molecular investigations into Wiskott-Aldrich Syndrome." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444028/.
Повний текст джерелаHughes, Fiona Lesley. "Molecular investigations of subgroup I geminiviruses." Doctoral thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/21979.
Повний текст джерелаThe diversity of Subgroup I geminiviruses causing streak disease in maize, sugarcane, and indigenous wild grasses was investigated. The virus. isolates studied originated from maize (several southern African isolates), two sugarcane cultivars (from Natal province, South Africa, and from Mauritius), wheat, and three grasses (Panicum, Setaria, and Eleusine spp. from South Africa). The following methods were used: analysis of restriction fragment length polymorphisms (RFLPs) between viral genomes in individual infected plants; DNA cross-hybridization between virus isolates; restriction endonuclease mapping of whole virus genomes; and nucleic acid sequencing. The complete genome of the Natal sugarcane streak virus isolate was sequenced. Partial sequences were obtained for other isolates, either by sequencing the ends of cloned viral genomes, or by sequencing a 250 base pair fragment of a highly conserved open reading frame that had been amplified using the polymerase chain reaction technique. The viruses being studied were compared both among themselves and with other Subgroup I geminiviruses of known DNA sequence, on the basis of sequence (nucleotide and amino acid) and restriction map data. Distance matrix methods were used to infer phylogenetic relationships between Subgroup I geminiviruses from restriction map and sequence data. Phylogenies deduced from sequence data were considered to be more accurate than those deduced from map data. Regardless of the method of analysis used, however, the relationships between the Subgroup I geminiviruses studied here remained constant. Thus, three strains of MSV (maize, Setaria, and Eleusine strains) were distinguished. Streak viruses distinct from MSV were also identified: panicum streak virus (PanSV), and two distantly related strains (Natal and Mauritius) of sugarcane streak virus (SSV). Restriction mapping of different geographical isolates of the maize strain of MSV demonstrated that variation existed within a single strain of virus. RFLP analysis indicated that minor variation existed between virus genomes within single diseased plants. Methods used to. type Subgroup I geminiviruses were evaluated, and discrepancies in the serological typing of geminiviruses from Subgroups I and III were pointed out. A unified scheme was proposed for distinguishing between distinct Subgroup I geminiviruses and strains of geminiviruses. The origins of maize and sugarcane streak viruses were speculated upon.
Kersell, Heath Ryan. "Investigations on the Complex Rotations of Molecular Nanomachines." Ohio University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1307126123.
Повний текст джерелаNair, Nisanth N. "Molecular dynamics investigations of clusters and solids." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=974372943.
Повний текст джерелаBirkenheuer, Adam Joseph. "Canine Babesiosis: Epidemiological, Molecular and Therapeutic Investigations." NCSU, 2004. http://www.lib.ncsu.edu/theses/available/etd-04192004-164025/.
Повний текст джерелаJohnson, Daniel. "Molecular level investigations of coiled-coil proteins." Thesis, University of Nottingham, 2006. http://eprints.nottingham.ac.uk/10174/.
Повний текст джерелаClark, Helen M. "Cytogenetic and molecular investigations of malignant lymphomas." Thesis, University of Southampton, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316515.
Повний текст джерелаKortunov, Pavel, Sergey Vasenkov, Jörg Kärger, Elía M. Fé, M. Perez, Michael Stöcker, George K. Papadopoulos, et al. "Investigations of molecular diffusion in FCC catalysts." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-196587.
Повний текст джерелаNatha, Khilona. "Molecular Forensic Investigations into Animal Sexual Abuse." Master's thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/32938.
Повний текст джерелаKortunov, Pavel, Sergey Vasenkov, Jörg Kärger, Elía M. Fé, M. Perez, Michael Stöcker, George K. Papadopoulos, et al. "Investigations of molecular diffusion in FCC catalysts." Diffusion fundamentals 2 (2005) 97, S. 1-2, 2005. https://ul.qucosa.de/id/qucosa%3A14435.
Повний текст джерелаWhitmore, Steven Scott. "Molecular investigations of age-related macular degeneration." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1798.
Повний текст джерелаO'Neill, Andrew. "Investigations in molecular structure : from scattering to molecular complexes of brominated compounds." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/1709/.
Повний текст джерелаSeibt, Joachim. "Theoretical investigations on the spectroscopy of molecular aggregates." kostenfrei, 2009. http://www.opus-bayern.de/uni-wuerzburg/volltexte/2009/3721/.
Повний текст джерелаNorton, Lisa K. "Spectroscopic investigations of dendritic polymers as molecular containers." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/6102.
Повний текст джерелаThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on September 22, 2008) Includes bibliographical references.
Waghorn, Philip A. "Investigations into porphyrins as potential molecular imaging agents." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526421.
Повний текст джерелаWentworth, Jonathan. "Molecular and cytogenetic investigations of some Alopecurus species." Thesis, University of East London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365947.
Повний текст джерелаGilder, Michael Frederick James. "Molecular investigations in animal models of Huntington's disease." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325046.
Повний текст джерелаReid, E. S. "Cellular and molecular investigations of undiagnosed neurometabolic disorders." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1516116/.
Повний текст джерелаShalaby, Nevine. "Genetic and molecular investigations of Drosophila Notch signaling." Thesis, Boston College, 2009. http://hdl.handle.net/2345/921.
Повний текст джерелаNotch signaling is an evolutionarily conserved developmental pathway regulated by two classes of transmembrane proteins: the Notch receptors and the Delta/Serrate/LAG-2 (DSL) ligands. Notch and DSL ligands mediate cell-cell communication that results in a downstream signaling cascade that affects many aspects of metazoan development. Additional regulatory mechanisms that affect Notch signaling are being discovered continuously, and recent findings highlight the importance of endocytosis, ubiquitylation and subcellular trafficking as essential requirements for proper signaling. In order to obtain further insights into the regulation of Notch signaling, I took a two-fold approach, combining genetic and molecular techniques in Drosophila. First, I took part in a large-scale transposon-based screen in the developing Drosophila eye to identify additional genes involved in the pathway. We screened 10,447 transposon lines from the Exelixis collection for modifiers of cell fate alterations caused by overexpression of Delta, and we identified 170 distinct modifier lines that may affect up to 274 genes. I further analyzed a previously uncharacterized gene, which we have named Amun, and showed that it localizes to the nucleus and contains a putative DNA glycosylase domain. Further analyses of Amun reveal that altered levels of Amun function interfere with cell fate specification during eye and sensory organ development. Second, to investigate structural requirements for ubiquitylation of Delta, I analyzed four individual lysine residues in the Delta intracellular domain, and assessed their necessity for Delta signaling activity. I find that a conserved residue, DeltaK742, is essential for Notch signaling in the Drosophila imaginal wing disc and is apparently required for ubiquitylation of Delta by the E3 ubiquitin ligase, Mind bomb1 (one of two E3 ubiquitin ligases required for Delta signaling activity). Taken together, the findings from this thesis research contribute to the advancement of our understanding of different aspects of Notch signaling and Notch-mediated development
Thesis (PhD) — Boston College, 2009
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Biology
Lambert, J. R. "Investigations into the molecular pathogenesis of essential thrombocythaemia." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1334502/.
Повний текст джерелаWaghorn, Philip Alan. "Investigations into porphyrins as potential molecular imaging agents." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669974.
Повний текст джерелаVan, der Walt Eric. "Experimental investigations of mastrevirus molecular biology and evolution." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/4346.
Повний текст джерелаIncludes bibliographical references (leaves 138-161).
This dissertation describes three major sets of experiments, all of which involved the construction and use of various reciprocal chimaeric MSV constructs. First, chimaeric viruses were used in genetic complementation-type experiments to investigate the biological significance of interactions between the two virion-sense open reading frames (ORFs) of MSV, their products, and the rest of the genome. Six chimaeric MSV constructs were made by reciprocally exchanging the ORFs encoding movement protein (MP) and coat protein (CP) individually, and in pairs, between MSV-Kom and MSV-Set, which share just 78% overall nucleotide identity. Analysis of symptomatology and infection efficiency of chimaeras and wild-type parental viruses revealed evidence of functionally relevant specific interactions between MSV MP and CP.
Wright, Mitchell Henry. "Physiological and Molecular Investigations of Manganese Transforming Bacteria." Thesis, Griffith University, 2014. http://hdl.handle.net/10072/368137.
Повний текст джерелаThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Physical Sciences
Science, Environment, Engineering and Technology
Full Text
Campana, Federica. "Molecular dynamics investigations of drug-cell membrane interactions." Doctoral thesis, Universita degli studi di Salerno, 2013. http://hdl.handle.net/10556/1325.
Повний текст джерелаThe cell membrane functions as a platform for the assembly of many signal transduction pathways and provides an additional level of regulation in cell signaling networks. The complex dynamic structure of the plasma membrane allows lipid–lipid and lipid–protein interactions, as well as the interaction of lipid–protein complexes with the submembrane cytoskeleton. The existence of membrane microdomains adds further complexity to such interactions, as well as the messages propagated in cells through G proteins and other non-permanent (extrinsic) membrane proteins. Each G protein can simultaneously bear a myristoyl, palmitoyl and isoprenyl moiety and therefore, many lipid molecules associated with G proteins may arise in G protein coupled receptor (GPCR)-rich membrane microdomains. These lipids can regulate the biophysical properties of membranes, which in turn modulate the interaction and activity of G proteins. The aim of the first part of my work was to understand the effect of these moieties on membrane structure and G protein-membrane interactions. Although recent studies found that the Gβγ dimer drives the interaction of G-proteins with nonlamellar-prone membranes, little is known about the molecular basis of this interaction. For this reason, I also investigated the interaction of the C-terminus of the Gγ protein with model membranes with or without the isoprenyl moieties. From the very beginning of my work, my studies have focused on the interaction of saturated and unsaturated fatty acids with cell membranes. Many of these molecules, in fact, have proven to be active against certain types of cancers and other diseases. Among all these molecules it is important to remember the Minerval, an analogue of oleic acid developed in the laboratory of Prof. Escribà, which has led to a reduction of up to 80% in the development of lung cancer and glioma cells. A promising molecule with high anti-inflammatory activity and synthesized by the group of Prof. Escribà like the previous one, is a modification of arachidonic acid: the 2-hydroxy arachidonic acid (AAOH). Due to the similarity with arachidonic acid (AA), that is the natural substrate of cyclooxygenase (COX), the second part of my work consisted in the investigation of the interaction of AAOH with COX-1 and COX-2. The results, in terms of free energy of binding and the Fukui function, demonstrated the potential of AAOH as non-toxic non-steroidal anti-inflammatory drug (NSAID). Recent findings pointed unambiguously to membranes as additional cellular sensors in activating a stress protein response, from prokaryotes to mammalian cells, at the beginning of temperature rise or other stresses. Aging or pathophysiological conditions can also be linked to the development of subtle membrane changes or “membrane-defects”, responsible for a dysregulated expression of heat shock proteins (HSPs). Chaperone co-inducers, among which can be mentioned the hydroxylamines such as BGP-15 and NG-094, are substances that cannot induce HSPs by itself, but can enhance HSP induction in combination with other mild stresses. A chaperone co-inducer also has the ability to lower the temperature threshold of the heat shock response and may provide suitable therapeutic candidates for many disease states since they are capable of affecting stressed rather than unstressed cells. The third part of my work consisted in molecular dynamics investigations of BGP-15 and NG-094 on membranes made of sphingomyelin and cholesterol at different composition to understand some aspects of membrane functioning. BGP-15 and NG-094 can induce an alteration in membrane’s fluidity similar to those induced by heat and a strong reorganization of sphingomyelin headgroups with an increased penetration of water. Taken together, all the results suggested that hydroxylamines have a strong effect on microdomains reorganization showing a great potential to become a new class of pharmaceuticals to combat most various protein-misfolding diseases and aging. All these investigations are relevant in the context of the physiology of cells, whose alterations may lead to pathologies whose treatment could be addressed by modifying membrane lipid composition and structure through so-called “Membrane-lipid therapy”. [edited by author]
XI n.s.
Iancu, Violeta. "Single Molecule Switches and Molecular Self-Assembly: Low Temperature STM Investigations and Manipulations." Ohio : Ohio University, 2006. http://www.ohiolink.edu/etd/view.cgi?ohiou1159980375.
Повний текст джерелаLama, Manoj. "Immunological and molecular investigations of childhood asthma in the Sub-Himalayan region of West Bengal, India." Thesis, University of North Bengal, 2014. http://hdl.handle.net/123456789/979.
Повний текст джерелаGC, Jeevan. "Molecular Dynamics Investigations of Structural Conversions in Transformer Proteins." FIU Digital Commons, 2017. http://digitalcommons.fiu.edu/etd/3225.
Повний текст джерелаvan, Kleef Eduard Hendrik. "Optical preparation of reagent states in molecular dynamics investigations." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357947.
Повний текст джерелаShiell, Ralph C. "Experimental investigations of doubly charged atomic and molecular species." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294869.
Повний текст джерелаBaker, Andrea Catherine. "Investigations into the molecular biology of the freshwater Cyanophages." Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421416.
Повний текст джерелаAust, Jonathan Gavin. "Molecular and physiological investigations of fish renin-angiotensin systems." Thesis, University of Exeter, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248168.
Повний текст джерелаArgyropoulos, George. "Molecular and genetic investigations of testicular development in mice." Thesis, University of Essex, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280829.
Повний текст джерелаFairbairn, L. J. "Investigations on erythrocyte membrane proteins using molecular cloning techniques." Thesis, University of Bristol, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379600.
Повний текст джерелаSheikh, Sohail Hamid. "Investigations of molecular fluorescence based measurement of DDT residues." Thesis, Cranfield University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267496.
Повний текст джерелаFairfax, Benjamin Peter. "Investigations into GABAB receptor surface stability and molecular interactions." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446808/.
Повний текст джерелаJaureguiberry, G. "Genetic and molecular investigations into Amelogenesis Imperfecta and Nephrocalcinosis." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1436084/.
Повний текст джерелаMancl, Jordan Michael. "Molecular Investigations of Protein Assemblies Involved in Prokaryotic Virulence." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/102298.
Повний текст джерелаDoctor of Philosophy
Mullins, Charles Buddie Weinberg Henry Weinberg Henry. "Molecular beam investigations of surface chemical reactions and dynamics /." Diss., Pasadena, Calif. : California Institute of Technology, 1990. http://resolver.caltech.edu/CaltechETD:etd-03122007-135158.
Повний текст джерелаMandhare, A. B. "NMR assisted investigations of molecular mobility in polymeric gels." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1998. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2934.
Повний текст джерелаHarris, Sarah Anne. "Theoretical investigations of DNA structure and dynamics." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368362.
Повний текст джерелаDunne, Emma Maria. "Investigations in trypanosome diversity and evolution using molecular phylogenetic analysis." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289775.
Повний текст джерелаBorwick, Simon John. "Computational investigations and rationalisations of molecular packing in crystalline materials." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398133.
Повний текст джерелаJonasson, L. "Computational investigations of the electronic structure of molecular actinide compounds." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/15798/.
Повний текст джерелаMossman, Sally Patricia. "Investigations into the biology and molecular biology of alphaherpesvirus saimiri." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291968.
Повний текст джерелаCooke, James C. "Molecular investigations of phaeochromocytoma tumourigenesis in von Hippel-Lindau disease." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417558.
Повний текст джерела