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Статті в журналах з теми "Moi-pro"
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Cardona-Mendoza, Andrés, Nelly Stella Roa Molina, Diana Marcela Castillo, Gloria Inés Lafaurie, and Diego Fernando Gualtero Escobar. "Human Coronary Artery Endothelial Cell Response to Porphyromonas gingivalis W83 in a Collagen Three-Dimensional Culture Model." Microorganisms 12, no. 2 (January 24, 2024): 248. http://dx.doi.org/10.3390/microorganisms12020248.
Повний текст джерелаАнотація:
P. gingivalis has been reported to be an endothelial cell inflammatory response inducer that can lead to endothelial dysfunction processes related to atherosclerosis; however, these studies have been carried out in vitro in cell culture models on two-dimensional (2D) plastic surfaces that do not simulate the natural environment where pathology develops. This work aimed to evaluate the pro-inflammatory response of human coronary artery endothelial cells (HCAECs) to P. gingivalis in a 3D cell culture model compared with a 2D cell culture. HCAECs were cultured for 7 days on type I collagen matrices in both cultures and were stimulated at an MOI of 1 or 100 with live P. gingivalis W83 for 24 h. The expression of the genes COX-2, eNOS, and vWF and the levels of the pro-inflammatory cytokines thromboxane A2 (TXA-2) and prostaglandin I2 (PGI2) were evaluated. P. gingivalis W83 in the 2D cell culture increased IL-8 levels at MOI 100 and decreased MCP-1 levels at both MOI 100 and MOI 1. In contrast, the 3D cell culture induced an increased gene expression of COX-2 at both MOIs and reduced MCP-1 levels at MOI 100, whereas the gene expression of eNOS, vWF, and IL-8 and the levels of TXA2 and PGI2 showed no significant changes. These data suggest that in the collagen 3D culture model, P. gingivalis W83 induces a weak endothelial inflammatory response.
2
Militzer, Burkhard, and William B. Hubbard. "Relation of Gravity, Winds, and the Moment of Inertia of Jupiter and Saturn." Planetary Science Journal 4, no. 5 (May 1, 2023): 95. http://dx.doi.org/10.3847/psj/acd2cd.
Повний текст джерелаАнотація:
Abstract We study the relationship of zonal gravity coefficients, J 2n , zonal winds, and axial moment of inertia (MoI) by constructing models for the interiors of giant planets. We employ the nonperturbative concentric Maclaurin spheroid method to construct both physical (realistic equation of state and barotropes) and abstract (small number of constant-density spheroids) interior models. We find that accurate gravity measurements of Jupiter’s and Saturn’s J 2, J 4, and J 6 by the Juno and Cassini spacecraft do not uniquely determine the MoI of either planet but do constrain it to better than 1%. Zonal winds (or differential rotation (DR)) then emerge as the leading source of uncertainty. For Saturn they are predicted to decrease the MoI by 0.4% because they reach a depth of ∼9000 km, while on Jupiter they appear to reach only ∼3000 km. We thus predict DR to affect Jupiter’s MoI by only 0.01%, too small by one order of magnitude to be detectable by the Juno spacecraft. We find that winds primarily affect the MoI indirectly via the gravity harmonic J 6, while direct contributions are much smaller because the effects of pro- and retrograde winds cancel. DR contributes +6% and −0.8% to Saturn’s and Jupiter’s J 6 value, respectively. This changes the J 6 contribution that comes from the uniformly rotating bulk of the planet that correlates most strongly with the predicted MoI. With our physical models, we predict Jupiter’s MoI to be 0.26393 ± 0.00001. For Saturn, we predict 0.2181 ± 0.0002, assuming a rotation period of 10:33:34 hr that matches the observed polar radius.
3
Rice, J. Hunter, Margaret M. McDaniel, Alyson Holland, and Shigetoshi Eda. "Modelling Bovine Granuloma Formation In Vitro upon Infection with Mycobacterium Avium Subspecies Paratuberculosis." Veterinary Sciences 6, no. 4 (October 12, 2019): 80. http://dx.doi.org/10.3390/vetsci6040080.
Повний текст джерелаАнотація:
Mycobacterium avium subspecies paratuberculosis (Map) causes chronic granulomatous disease in cattle and ruminant livestock, causing substantial economic losses. Current vaccines delay clinical signs but cannot train the immune system to fully eradicate latent Map. During latency, Map uses host defenses, cage-like macrophage clusters called granuloma, as incubators for months or years. We used an in vitro model to investigate the early coordination of macrophages into granuloma upon Map infection over ten days. We found that at multiplicities of infection (MOI; Map:macrophages) of 1:2 and below, the macrophages readily form clusters and evolve pro-inflammatory cytokines in keeping with a cell-mediated immune response. At higher MOIs, viability of host macrophages is negatively impacted. At 1:4 MOI, we quantified viable Map in our model and confirmed that intracellular Map reproduced over the first five days of infection. Host cells expressed Type 1-specific cytokines, and Map-infected macrophages displayed reduced motility compared to Map-exposed, uninfected macrophages, suggesting an important role for uninfected macrophages in the early aggregative response. Reported is the first in vitro JD granuloma model capturing Map and macrophage viability, size distribution of resulting clusters, motility of monocyte-derived macrophages, and cytokine response during clustering, allowing quantitative analysis of multiple parameters of the Map-specific granulomatous response.
4
Maldonado, David, Vivian Ouyang, Jade Owens, Andrew Jimenez, Benjamin Saks, Payam Sabetian, Ajay Lall, and Benjamin Domb. "Paper 57: Labral Tear Management in Patients Aged 40 Years and Older Undergoing Primary Hip Arthroscopy: A Propensity-Matched Case-Control Study Comparing Labral Reconstruction to Labral Repair with Minimum Two-Year Follow-Up. *ACCEPTED TO AJSM*." Orthopaedic Journal of Sports Medicine 10, no. 7_suppl5 (July 1, 2022): 2325967121S0062. http://dx.doi.org/10.1177/2325967121s00620.
Повний текст джерелаАнотація:
Objectives: To report minimum two-year patient-reported outcome (PRO) scores, survivorship, and secondary surgeries, in patients aged ≥ 40 years who underwent primary hip arthroscopy with labral reconstruction compared to a propensity-matched primary labral repair group. Methods: Data were prospectively collected and retrospectively reviewed for patients who underwent a primary hip arthroscopy for femoroacetabular impingement syndrome from January 2014 to June 2018. Patients aged ≥ 40 years who underwent a labral reconstruction or a labral repair and had preoperative and minimum two-year PROs for the modified Harris Hip Score (mHHS), Non-arthritic Hip Score (NAHS), and visual analog scale (VAS) for pain were included. Patients with prior ipsilateral hip conditions and surgery, Tonnis grade > 1, hip dysplasia, or worker’s compensation status were excluded. Patients in the reconstruction group were propensity-matched 1:2 to patients in the repair group based on age, sex, and body mass index. Secondary surgeries and the achievement of the minimal clinically importance difference (MCID), patient acceptable symptomatic state (PASS), and maximum outcome improvement (MOI) were recorded. Results: Fifty-three and 106 hips were included in the labral reconstruction and repair groups, respectively. The average follow-up time was 37.6 months. The average age for the reconstruction and repair groups were 48.01 ± 5.4 years and 48.61 ± 6.0 years, respectively. Both groups achieved significant improvements in all PROs at minimum two-years with similar achievements of MCID, PASS, and MOI. Both groups showed comparable secondary surgeries rates. Conclusions: Patients aged 40 years and older who received primary labral repair and primary labral reconstruction, achieved similar significant improvements in all PROs, VAS pain, and patient satisfaction at minimum two-year follow-up, with comparable rates of secondary surgeries and achieving MCID, PASS, and MOI. Based on these findings, labral repair remains the gold standard treatment for viable labrum in this population group, while reconstruction is a useful alternative for irreparable labrum.
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Maldonado, David R., Vivian W. Ouyang, Jade S. Owens, Andrew E. Jimenez, Benjamin R. Saks, Payam W. Sabetian, Ajay C. Lall, and Benjamin G. Domb. "Labral Tear Management in Patients Aged 40 Years and Older Undergoing Primary Hip Arthroscopy: A Propensity-Matched Case-Control Study With Minimum 2-Year Follow-up." American Journal of Sports Medicine 49, no. 14 (October 15, 2021): 3925–36. http://dx.doi.org/10.1177/03635465211046915.
Повний текст джерелаАнотація:
Background: Previous literature has suggested that primary acetabular labral reconstruction leads to lower secondary surgery rates than does labral repair for patients aged ≥40 years. Purpose: To report minimum 2-year patient-reported outcome (PRO) scores, survivorship, and secondary surgeries in patients aged ≥40 years who underwent primary hip arthroscopy with labral reconstruction compared with a propensity-matched primary labral repair group. Study Design: Case-control study; Level of evidence, 3. Methods: Data were prospectively collected and retrospectively reviewed for patients who underwent a primary hip arthroscopy for femoroacetabular impingement syndrome between January 2014 and June 2018. Patients aged ≥40 years who underwent a labral reconstruction or a labral repair and had preoperative and minimum 2-year PROs for the modified Harris Hip Score, Nonarthritic Hip Score, and visual analog scale (VAS) for pain were included. Patients with previous ipsilateral hip conditions and surgery, Tönnis grade >1, hip dysplasia, or workers’ compensation status were excluded. Patients in the reconstruction group were propensity matched 1:2 to patients in the repair group based on age, sex, and body mass index. Secondary surgeries and achievement of the minimal clinically important difference (MCID), patient acceptable symptom state (PASS), and maximum outcome improvement (MOI) were recorded. Results: A total of 53 and 106 hips were included in the labral reconstruction and repair groups, respectively. The average follow-up time was 37.6 months. The average ages for the reconstruction and repair groups were 48.01 ± 5.4 years and 48.61 ± 6.0 years, respectively. Both groups achieved significant improvements in all PROs at a minimum of 2 years, with similar achievements of MCID, PASS, and MOI, and comparable secondary surgery rates. Conclusion: Patients aged ≥40 years who received primary labral repair and primary labral reconstruction achieved similar significant improvements in all PROs, VAS pain, and patient satisfaction at the minimum 2-year follow-up, with comparable rates of secondary surgeries and achieving MCID, PASS, and MOI. Based on these findings, labral repair remains the gold standard treatment for viable labrum in this population group, while reconstruction is a useful alternative for irreparable labrum.
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L Katche, Musong, Augustine B Makokha, Siagi O Zachary, and Muyiwa S Adaramola. "Solar Photovoltaic Systems: A Technical and Economic Feasibility Design Approach with Homer Pro." International Journal of Advances in Scientific Research and Engineering 09, no. 11 (2023): 21–30. http://dx.doi.org/10.31695/ijasre.2023.9.11.2.
Повний текст джерелаАнотація:
With the declining cost of solar photovoltaic (PV) modules and batteries used for energy storage, many users are now shifting towards solar energy because of its renewable nature and availability. Though this is a great step to combat climate change, most of the solar systems installed always fail due to poor system sizing. For this reason, optimal systems are required to be deployed. This paper presents a technical and economic feasibility design approach for a solar PV system using Hybrid Optimization of Multiple Energy Resources (HOMER) Pro software. The design is based on site-specific data collected from Moi University in Kenya. The temperature and solar radiation data were collected fromthe weather station of the university, while the power demand data was collected from the Margaret Thatcher Library of the university using the PCE-360 power analyzer.The simulation results show that a 100kW solar PV system is required to power the Margaret Thatcher library with a financial investment of KES 32,000,000. This system is strongly recommended to be used by the university as it will ensure reliability of power supply for students to study and also save on costs incurred on utility bills.
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Bajaber, Gamar, Constantine Akwanalo, and Shameem Ali. "Proportion, Precipitators and Prognostic Marker of 30-Day Heart Failure Readmission at MOI Teaching and Referral Hospital, Eldoret, Kenya." International Journal of Research and Scientific Innovation VII, no. XI (2023): 110–25. http://dx.doi.org/10.51244/ijrsi.2023.1011008.
Повний текст джерелаАнотація:
Background: Heart failure (HF) affects 26 million people globally. It is associated with a high 30-day readmission rate due to multiple cardiovascular and non-cardiovascular precipitants. Readmissions are associated with high mortality, which may be predicted by pre-discharge N-terminal pro brain natriuretic peptide (NT-proBNP). There is no data on HF readmission rates, its precipitators and use of NT-proBNP as a prognostic marker at Moi Teaching and Referral Hospital (MTRH) in Western Kenya. Objective: To determine the 30-day proportion of HF readmission, the precipitators of HF and the association between NT-proBNP and 30 days’ readmission. Methods:This was a six-month prospective cohort study where we carried out a census and recruited adult participants admitted with HF at Moi Teaching and Referral Hospital. At discharge from hospital, an interviewer administered questionnaire was administered and blood samples for NT-proBNP drawn. Upon readmission, precipitators for HF were identified and compliance to therapy assessed using European heart failure Self Care Behavioral Scale. Continuous variables were summarized using median and IQR, categorical variables using frequencies and percentages. Associations were determined using Chi square, Fishers exact and Wilcoxon rank test. A p-value of <0.05 was considered statistically significant. Results: From April to November 2018, 94 participants were recruited into the study; with median age 48 years (IQR 31,70), 58 (62%) were female, 35 (38%) consumed alcohol and 25(25%) smoked. Hypertension was the commonest comorbidity 20 (21%) while cardiomyopathy was the underlying etiology for HF in 58 (63%). HF with reduced Ejection Fraction (HFrEF) was present in 76% of the participants while 24% had HF with preserved Ejection Fraction (HFpEF). Sixty percent of the participants had NT-proBNP levels of >4137 pg/ml, which implied poor prognosis. Of 17 readmitted patients, 12 participants (12.8%) were readmitted within 30 days at MTRH. Six (6.4%) participants were lost to follow up. Median time to readmission was 14 days, (IQR 7, 26). Pneumonia (55%) was the commonest precipitator of HF readmissions, followed by arrhythmias (atrial fibrillation) in 5 (42%), anemia 4 (33%), noncompliance 4 (33%), acute kidney injury 2 (16.6%) and no identified precipitator 1 (8.3%). There was no association between NT-proBNP and readmission (p =0.584) or NT-pro BNP and survival (p=0.773). Readmission was associated with a high mortality (p=0.008) with 50% of readmitted participants dying during the readmission period. The total mortality of both readmitted and non-readmitted participants was 16% at the end of the 6 months’ study period. Conclusions:In this cohort of participants with HF the proportion of 30 days readmission was high. Infections, mainly pneumonia was the commonest precipitator of readmission. Discharge NT-proBNP did not predict likelihood of 30 days’ readmission. Mortality was higher among participants readmitted within 30 days. Recommendations: Measures like pneumoccal vaccinations should be implemented to prevent pneumonia. Early appointments to cardiac clinic (less than 2 weeks post discharge) should be given to screen for precipitators and reduce HF readmissions. A follow up study to assess % change in NT pro BNP in relation to 30 days readmission.
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A . Hussein, Ahmed, and Adnan F. Hassan. "Performance Enhancement of Luminescent Solar Concentrator by using Mixing Fluorescent Colors and Nanoparticles." Journal of Kufa-Physics 14, no. 01 (August 12, 2022): 17–25. http://dx.doi.org/10.31257/2018/jkp/2022/140106.
Повний текст джерелаАнотація:
Liquid zinc acetate nanoparticles were added to a fluorescent organic dye (fluorescein sodium) to prepare three concentrations (2 × 10-5, 7×10-5, 1×10-4) moI/L, and the absorbance of the dye was measured before and after adding Liquid nanomaterial by using two devices (SCINCO Mega-2100 UV/visible Spectrophotometer.) as well as measuring the flux of the dye before and after adding zinc acetate nanoparticles using the (Spectrofluorometer F96 PRO). The Stoke displacement (Δη), the radiative age (τfm), the fluorescence lifetime (τf), and the quantitative efficiency (Qfm) were calculated. Absorption and fluorescence curves were drawn using the Excel program. The MATLAB program was also used to measure the area under the absorption and fluorescence spectra curves. It was found that the fluorescence intensity of fluorescein sodium dye has increased compared to the intensity of fluorescence before adding the nanomaterial and thus increasing the quantitative efficiency, which in turn helps in improving the performance of the photovoltaic concentrator, resulting in an improvement in the efficiency of the solar cell.
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Barletta, Raul G., John P. Bannantine, Judith R. Stabel, Ezhumalai Muthukrishnan, Dirk K. Anderson, Enakshy Dutta, Vamsi Manthena, Mostafa Hanafy, and Denise K. Zinniel. "Mycobacterium avium subsp. paratuberculosis Candidate Vaccine Strains Are Pro-apoptotic in RAW 264.7 Murine Macrophages." Vaccines 11, no. 6 (June 10, 2023): 1085. http://dx.doi.org/10.3390/vaccines11061085.
Повний текст джерелаАнотація:
Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne’s disease, a severe gastroenteritis of ruminants. This study developed a model cell culture system to rapidly screen MAP mutants with vaccine potential for apoptosis. Two wild-type strains, a transposon mutant, and two deletion mutant MAP strains (MOI of 10 with 1.2 × 106 CFU) were tested in murine RAW 264.7 macrophages to determine if they induce apoptosis and/or necrosis. Both deletion mutants were previously shown to be attenuated and immunogenic in primary bovine macrophages. All strains had similar growth rates, but cell morphology indicated that both deletion mutants were elongated with cell wall bulging. Cell death kinetics were followed by a real-time cellular assay to measure luminescence (apoptosis) and fluorescence (necrosis). A 6 h infection period was the appropriate time to assess apoptosis that was followed by secondary necrosis. Apoptosis was also quantified via DAPI-stained nuclear morphology and validated via flow cytometry. The combined analysis confirmed the hypothesis that candidate vaccine deletion mutants are pro-apoptotic in RAW 264.7 cells. In conclusion, the increased apoptosis seen in the deletion mutants correlates with the attenuated phenotype and immunogenicity observed in bovine macrophages, a property associated with good vaccine candidates.
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Knezevic, Petar, Aleksandra Petrovic Fabijan, Damir Gavric, Jovana Pejic, Zsolt Doffkay, and Gábor Rakhely. "Phages from Genus Bruynoghevirus and Phage Therapy: Pseudomonas Phage Delta Case." Viruses 13, no. 10 (September 30, 2021): 1965. http://dx.doi.org/10.3390/v13101965.
Повний текст джерелаАнотація:
The applicability and safety of bacteriophage Delta as a potential anti-Pseudomonas aeruginosa agent belonging to genus Bruynoghevirus (family Podoviridae) was characterised. Phage Delta belongs to the species Pseudomonas virus PaP3, which has been described as a temperate, with cos sites at the end of the genome. The phage Delta possesses a genome of 45,970 bp that encodes tRNA for proline (Pro), aspartic acid (Asp) and asparagine (Asn) and does not encode any known protein involved in lysogeny formation or persistence. Analysis showed that phage Delta has 182 bp direct terminal repeats at the end of genome and lysogeny was confirmed, neither upon infection at low nor at high multiplicity of infection (MOI). The turbid plaques that appear on certain host lawns can result from bacteriophage insensitive mutants that occur with higher frequency (10−4). In silico analysis showed that the genome of Delta phage does not encode any known bacterial toxin or virulence factor, determinants of antibiotic resistance and known human allergens. Based on the broad host range and high lytic activity against planktonic and biofilm cells, phage Delta represents a promising candidate for phage therapy.
Дисертації з теми "Moi-pro"
1
Grenier, André. "Du moi au pro-soi contribution phénoménologique à une nouvelle représentation du sujet." Dijon, 1997. http://www.theses.fr/1997DIJOL010.
Повний текст джерелаАнотація:
Ni "je" comme sujet transcendantal, ni "moi" comme être objective, la réalité humaine se manifeste par la réalisation toujours en cours d'un soi à devenir. Nommer le mouvement existentiel individuel doit permettre de renouveler la conceptualisation de cet "être-moi" dont je ne suis pas le fondement mais que je dois cependant assumer. Designer par "pro-soi" le geste d'être par lequel je me présente apporte une dimension "ipsologique" aux perspectives ontologique de l'existentialisme, axiologique de la métaphysique et pratique (en éducation, psychologie et médecine), de l'assomption de soiNeither the "i" as a transcendental subject, nor the "ego" as an objectified being, human reality appears through the neverending realization of a self to become. To name the existential and individual movement is to allow for the renewal of the conceptualization of this "ego-being" of which i am not the foundation, but which i must however assume. Meaning by "pro-self" the gesture or being through which i am introducing myself adds an "ipsological" dimension to the ontological perspective of existentialism, to the axiological perspective of methaphysics as well as to the practical perspective (in education, psychology and medicine) of self-assumption
2
Mialhe, Stéphanie. "Vécus de violences professionnelles et décompensation cancéreuse : Recherche en psychologie clinique." Electronic Thesis or Diss., Lyon 2, 2024. http://www.theses.fr/2024LYO20019.
Повний текст джерелаАнотація:
L’enjeu principal de cette recherche est de questionner les liens éventuels entre les décompensations cancéreuses et les situations professionnelles vécues comme violentes et traumatiques. En effet, à partir de sa clinique dans un service d’onco-hématologie et à la suite de plusieurs rencontres avec des sujets invoquant la sphère professionnelle comme responsable de leur affection, l’auteure a souhaité mener sur le terrain des investigations plus étendues et précises autour de ce sujet. Les objectifs étaient de se rendre compte du nombre potentiel de sujets « malades du travail » et de s’entretenir avec eux en vue de repérer les mouvements conscients et inconscients contributeurs, entre autres facteurs selon eux, à une telle situation somatique.Les entretiens cliniques avec vingt sujets, très investis dans leur travail, ont mis en lumière pour ces derniers les effets d’/de (ob)scénalisation de la scène inconsciente sur la scène professionnelle et la possible collision traumatique entre ces deux scènes. Ses hypothèses théoriques ont permis à l’auteure de proposer une compréhension de ses mouvements à travers l’existence d’un Moi-pro en lien avec des enveloppes institutionnelles - composées de l’Institution, de l’organisation du travail et des différents groupes auxquels le travailleur appartient – qui seraient au service de l’équilibre psychique et somatique du sujet lorsque sa subjectivité se déploie au travail. Inversement, lorsque la subjectivité est empêchée, l’auteure a montré comment les éléments autrefois contenus et/ou métabolisés pouvaient faire retour et faire écho aux éléments non liés de l’inconscient amential provoquant une somatisation grave (la dysfiliation originelle et primaire venant se collapser de manière traumatique à la désaffiliation professionnelle)The main aim of this research is to examine the possible links between cancer decompensation and work situations experienced as violent and traumatic. Based on her clinical experience in an onco-haematology department, and following a number of encounters with subjects who cited the professional sphere as the cause of their illness, the author wished to carry out more extensive and precise field investigations into this subject. The aim was to find out how many subjects were potentially 'work-sick', and to talk to them in order to identify the conscious and unconscious movements that, in their view, contributed to such a somatic situation, among other factors.The clinical interviews with twenty subjects, who were highly committed to their work, highlighted the effects of (ob)scenalisation of the unconscious scene on the professional scene, and the possible traumatic collision between these two scenes. Her theoretical hypotheses enabled the author to propose an understanding of these movements through the existence of an ego-pro linked to institutional envelopes - made up of the institution, the work organisation and the various groups to which the worker belongs - which would serve the subject's psychic and somatic equilibrium when his subjectivity unfolds at work. Conversely, when subjectivity is prevented, the author has shown how elements previously contained and/or metabolised can come back and echo the unbound elements of the amential unconscious, causing serious somatisation (the original and primary dysfiliation collapsing in a traumatic way with professional disaffiliation)
Книги з теми "Moi-pro"
1
Grenier, André. Du moi au Pro-soi: Contribution phénoménologique à une nouvelle représentation du sujet. Lille: A.N.R.T. Université de Lille III, 1997.
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