Добірка наукової літератури з теми "Modular PKS engineering"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "Modular PKS engineering".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Статті в журналах з теми "Modular PKS engineering":
Beck, Charlotte, Jaime Felipe Guerrero Garzón, and Tilmann Weber. "Recent Advances in Re-engineering Modular PKS and NRPS Assembly Lines." Biotechnology and Bioprocess Engineering 25, no. 6 (December 2020): 886–94. http://dx.doi.org/10.1007/s12257-020-0265-5.
Wesener, Shane R., Vishwakanth Y. Potharla, and Yi-Qiang Cheng. "Reconstitution of the FK228 Biosynthetic Pathway Reveals Cross Talk between Modular Polyketide Synthases and Fatty Acid Synthase." Applied and Environmental Microbiology 77, no. 4 (December 23, 2010): 1501–7. http://dx.doi.org/10.1128/aem.01513-10.
Musiol-Kroll, Ewa, and Wolfgang Wohlleben. "Acyltransferases as Tools for Polyketide Synthase Engineering." Antibiotics 7, no. 3 (July 18, 2018): 62. http://dx.doi.org/10.3390/antibiotics7030062.
Rascher, Andreas, Zhihao Hu, Greg O. Buchanan, Ralph Reid, and C. Richard Hutchinson. "Insights into the Biosynthesis of the Benzoquinone Ansamycins Geldanamycin and Herbimycin, Obtained by Gene Sequencing and Disruption." Applied and Environmental Microbiology 71, no. 8 (August 2005): 4862–71. http://dx.doi.org/10.1128/aem.71.8.4862-4871.2005.
He, Yunlong, Yuhui Sun, Tiangang Liu, Xiufen Zhou, Linquan Bai, and Zixin Deng. "Cloning of Separate Meilingmycin Biosynthesis Gene Clusters by Use of Acyltransferase-Ketoreductase Didomain PCR Amplification." Applied and Environmental Microbiology 76, no. 10 (March 26, 2010): 3283–92. http://dx.doi.org/10.1128/aem.02262-09.
Haydock, Stephen F., Anthony N. Appleyard, Tatiana Mironenko, John Lester, Natasha Scott, and Peter F. Leadlay. "Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449." Microbiology 151, no. 10 (October 1, 2005): 3161–69. http://dx.doi.org/10.1099/mic.0.28194-0.
Agergaard, Julie Krogh, Kristoffer Wernblad Sigsgaard, Niels Henrik Mortensen, Simon Didriksen, Kasper Barslund Hansen, and Jingrui Ge. "MODULAR MAINTENANCE DECISION ARCHITECTURE." Proceedings of the Design Society 3 (June 19, 2023): 2715–24. http://dx.doi.org/10.1017/pds.2023.272.
Wang, Guimei, Lijie Yang, and Yong Shuo Zhang. "Modularized design of coal-mine paste filling station based on fuzzy theory." World Journal of Engineering 15, no. 6 (December 3, 2018): 743–50. http://dx.doi.org/10.1108/wje-01-2018-0006.
Rana, Vighneshkumar, and Vishal Singh. "Analyzing the dimensional aspects of 3D volumetric spaces: a product-oriented perspective." Proceedings of the Design Society 4 (May 2024): 2433–42. http://dx.doi.org/10.1017/pds.2024.246.
Breimann, Richard, Christoph Rennpferdt, Sven Wehrend, Eckhard Kirchner, and Dieter Krause. "EXPLOITING THE SUSTAINABILITY POTENTIAL OF MODULAR PRODUCTS BY INTEGRATING R-IMPERATIVES INTO PRODUCT LIFE PHASES." Proceedings of the Design Society 3 (June 19, 2023): 1785–94. http://dx.doi.org/10.1017/pds.2023.179.
Дисертації з теми "Modular PKS engineering":
Su, Li. "Generation of analogues of the anti-tumor polyketide stambomycins by genetic engineering and allied approaches." Electronic Thesis or Diss., Université de Lorraine, 2021. http://www.theses.fr/2021LORR0081.
The polyketide secondary metabolites of bacteria are a rich source of bioactive agents, with notable applications in anti-infective and anti-cancer therapy. However, their structures often need to be optimized in order to tailor their therapeutic and biophysical properties. The 51-membered macrolide stambomycins, among the largest of known polyketides, were recently discovered by genome mining in Streptomyces ambofaciens ATCC23877, and notably exhibit promising anti-cancer activity. The family encompasses six members which differ from each other in the alkyl functionality at C-26, due to the alternative choice of extender units by an exceptional acyl transferase domain (AT12) of the modular polyketide synthase (PKS) responsible for synthesizing the stambomycin core. Given their enormous size of the stambomycins and the intrinsic promiscuity of AT12, there is substantial interest in accessing ring-contracted and C-26 substituted derivatives of this compounds which might retain the bioactivity of the parental structures, or exhibit improved or even new properties. In this work, we have leveraged our current understanding of modular PKS systems to internally contract the stambomycin assembly line, leading to the successful generation, albeit at low yield, of target smaller derivatives (37-membered ‘mini-stambomycins’). By careful analysis, we could identify multiple factors contributing to the low titers, information which should inform future engineering strategies. Furthermore, using a mutasynthesis strategy, we were able to exploit the broad specificity of the AT12 domain to create 6 novel C-26 substituted stambomycin analogues. Finally, we unexpectedly identified three series of novel desferrioxamine siderophores produced by S. ambofaciens. As a number of key metabolites generated in this work have potential interest for therapeutic applications, they will be targeted for purification, structural characterization and biological evaluation
Zarzoso, Vicente. "Traitement aveugle et semi-aveugle du signal pour les télécommunications et le génie biomédical." Habilitation à diriger des recherches, Université de Nice Sophia-Antipolis, 2009. http://tel.archives-ouvertes.fr/tel-00486872.
Частини книг з теми "Modular PKS engineering":
JianBing, Chen. "PEEK and PES ☆." In Reference Module in Materials Science and Materials Engineering. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-803581-8.02607-2.
Glinsky, Albert. "A Eunuch in a Harem." In Switched On, 80—C8.P38. Oxford University PressNew York, 2022. http://dx.doi.org/10.1093/oso/9780197642078.003.0008.
Subirats, X., E. Fuguet, M. Rosés, E. Bosch, and C. Ràfols. "Methods for pKa Determination (I): Potentiometry, Spectrophotometry, and Capillary Electrophoresis." In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-409547-2.11559-8.
Qin, Weijin, Ya Liu, and Xuhai Yang. "Performance Analysis on a Traceable Precise Satellite Timing." In Advances in Transdisciplinary Engineering. IOS Press, 2022. http://dx.doi.org/10.3233/atde221204.
Fuguet, E., X. Subirats, C. Ràfols, E. Bosch, and M. Rosés. "Methods for pKa Determination (II): Sparingly Soluble Compounds and High-Throughput Approaches." In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-409547-2.11631-2.
Тези доповідей конференцій з теми "Modular PKS engineering":
Zhang, Dan, Lihui Wang, and Sherman Y. T. Lang. "Modelling and Control of PKM in an Integrated Environment." In ASME 2003 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/detc2003/cie-48178.
Kitzmiller, John T., Richard G. Anderson, Laura L. Genutis, and Dennis M. Popp. "Effects on Core Damage Frequency to Sensitivity of Instrumentation and Control Reliability." In 17th International Conference on Nuclear Engineering. ASMEDC, 2009. http://dx.doi.org/10.1115/icone17-75413.
Han, Changwan, Seonghun Park, and Hanjong Kim. "Dynamic Response of Polyvinyl Alcohol(PVA)-Hydrogel With Different PVA Concentrations." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-37811.
Eilmus, Sandra, and Dieter Krause. "Product Life-Oriented Development of Component Commonality and Variety." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-63619.
Müller, Andreas. "A Lie Group Approach to the Modular Modeling of Kinematically Non-Redundant Parallel Mechanisms." In ASME 2019 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/detc2019-98283.
Zhang, Dan, Lihui Wang, and Sherman Y. T. Lang. "An Integrated Virtual Validation System for Parallel Kinematic Machine Analysis Design." In ASME 2003 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/detc2003/dac-48825.
Chen, Hui, and Zhixing Wang. "Computer Aided Manufacturing of Marine Propellers by Parallel Kinematics Machine." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-41727.
Pradhan, A. K., A. Routray, and A. Behera. "Power quality disturbance classification employing modular wavelet network." In 2006 IEEE Power Engineering Society General Meeting. IEEE, 2006. http://dx.doi.org/10.1109/pes.2006.1709452.
Wehlin, Camilla, Olle Vidner, Leon Poot, and Mehdi Tarkian. "Integrating Sales, Design and Production: A Configuration System for Automation in Mass Customization." In ASME 2021 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/detc2021-68426.
Yu, Mingrui, Hongliang Wang, Zhuo Liu, Yu Feng, Xu Han, and Yidan Yuan. "Experimental Research on Drag Characteristic of Air Flow Path for ACP-100 Passive Containment Air Cooling System." In 2022 29th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/icone29-91504.