Дисертації з теми "Modelling WPT"
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Simpson, Duncan Alexander. "Numerical modelling of condensing wet-steam flows." Thesis, University of Cambridge, 2004. https://www.repository.cam.ac.uk/handle/1810/272051.
Повний текст джерелаLund, I. D. "Hydrodynamics and mass transfer problems in wet spinning." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370283.
Повний текст джерелаTerrill, E. L. "Mathematical modelling of some spinning processes." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280001.
Повний текст джерелаMartinsson, Joel. "Controlled Start Transmission Wet Clutch Temperature Modeling and Application." Thesis, Linköpings universitet, Fordonssystem, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122166.
Повний текст джерелаMaljaars, Marianne Dina. "Modelling the wind transport of sand over wet surfaces." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq21694.pdf.
Повний текст джерелаShirt, Roger William. "Modelling and identification of paper machine wet end chemistry." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0017/NQ27246.pdf.
Повний текст джерелаEnache, Alexandru Alin. "Mathematical modelling of the chitosan fiber formation by wet-spinning." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1100/document.
Повний текст джерелаChitosan is a natural polymer obtained by deacetylation of chitin. This polysaccharide is well known for its exceptional biological properties: it is biocompatible and bio absorbable. Chitosan fibers can be used in surgery.The objective of this thesis is to study the physicochemical phenomena involved, to develop a process model, to optimize the filtering process in the laboratory.After a review of the literature in the first chapter, the experimental techniques for obtaining, purifying and characterizing chitosan are described in the second chapter. A study of the structure of the chitosan obtained is presented. This is one of the original results of this work.The principle of the coagulation method in solution, it is essential to determine in what condition it, and what is the determining parameter. Previous studies have shown that this is the diffusion coefficient of soda in the medium. One effect, measurements were made, in different geometries. This study constitutes the work presented in Chapter Three.In chapter four is presented a technique consisting in following by means of a microscope the advance of the coagulation front. This technique makes it possible to determine the diffusion coefficient.The last chapter consisted of developing fibers using a small scale plant existing in laboratory (IMP Lyon 1). The final element of this work consists of modelling the process, calculating the inside and outside diameters of the fibers obtained and comparing the result of the modelling with the experimental results
Webb, R. A. "Experimental modelling of nucleating and wet steam flows in turbine blading." Thesis, University of Birmingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.643570.
Повний текст джерелаRyazanov, Andrey. "Pore scale network modelling of residual oil saturation in mixed-wet systems." Thesis, Heriot-Watt University, 2012. http://hdl.handle.net/10399/2546.
Повний текст джерелаHutton-Smith, Laurence. "Modelling the pharmacokinetics and pharmacodynamics of macromolecules for the treatment of wet AMD." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:5c6d908f-ebf1-4006-8666-862a17c3f799.
Повний текст джерелаLo, Johnny Su Hau. "Estimation of tropospheric wet delay from GNSS measurements." Thesis, Curtin University, 2011. http://hdl.handle.net/20.500.11937/2289.
Повний текст джерелаEftaxias, Athanasios. "Catalytic wet air oxidation of phenol in a trickle bed reactor: kinteics and reactor modelling." Doctoral thesis, Universitat Rovira i Virgili, 2003. http://hdl.handle.net/10803/8517.
Повний текст джерелаEl tratamiento y el reciclaje de afluentes acuosos son de máximo interés para conseguir un desarrollo sostenible de las actividades humanas. La necesidad de aprovechar en un futuro cercano las aguas residuales de procesos industriales de un modo eficaz ha reforzado la investigación sobre métodos de bajo coste para su recuperación, dado que las tecnologías existentes ya no son universalmente aplicables. La oxidación catalítica por vía húmeda (CWAO) es uno de los procesos emergentes más prometedores particularmente para el tratamiento de aguas contaminadas con materia orgánica, en concentraciones medio altas, y/o biotóxica. Sin embargo, la implementación del método es adecuada siempre que se use un catalizador activo y estable. Con este propósito, la actividad catalítica y la estabilidad del carbón activo se ha comprobado en la CWAO usando como compuesto modelo el fenol. En condiciones de temperatura y presión moderadas el carbón activo ha demostrado ser un material catalítico barato, que a la vez, es estable, mas activo en la conversión de fenol, además produciendo menor cantidad de productos de oxidación parcial tóxicos que los catalizadores soportados convencionales. Durante la CWAO del fenol, numerosos productos intermedios se forman, por lo que el conocimiento de la cinética de su oxidación es fundamental para el diseño, modelización y escalado fiable del proceso a escala de planta piloto o incluso industrial. Debido a la insuficiencia de los clásicos métodos de optimización para llevar acabo la estimación de parámetros en modelos de alta complejidad, el uso de algoritmos estocásticos se ha probado con éxito, permitiendo el desarrollo de modelos cinéticos más avanzados que los que se implementan actualmente en el campo de la CWAO. El desarrollo de modelos cinéticos complejos es escaso en la literatura actual, así como los estudios que tratan los aspectos químicos y de ingeniería del proceso de la CWAO. Sin embargo, hay una necesidad clara para el desarrollo simultaneo de los aspectos químicos y de ingeniería de la tecnología. Consecuentemente, en paralelo se ha enfocado en la modelización de un reactor de goteo (TBR), según el estado de arte actual en el campo de estos reactores. Es demostrado que estos reactores son más adecuados que los reactores agitados con catalizador en suspención para la CWAO de compuestos orgánicos que tienden a reacciones de polimerización en fase liquida. Además se han probado dos distintos modos de operación, con flujo de gas y liquido cocorriente descendiente o ascendiente, y se ha demostrado que la primera forma de operación es la mas adecuada para este sistema. A continuación un modelo fenomenológico para el TBR ha sido desarrollado y programado. El modelo implementa la cinética previamente obtenida, y además se ha puesto énfasis en la incorporación de los efectos de mojado, y de transferencia de materia. La operación no isotérmica se ha estudiado también para investigar la posibilidad de operar de modo autotérmico, disminuyendo así los costes de operación del proceso. La validación del modelo fenomenológico con los datos experimentales obtenidos en el TBR del laboratorio ha sido favorable. Posteriormente, este modelo ha sido utilizado como una herramienta fiable para el escalado del proceso. Los resultados obtenidos de la modelización del escalado permiten la extracción de recomendaciones sobre el diseño y la operación de unidades industriales, haciendo más fiable la aplicación del método a escala industrial.
Zhang, Yicheng. "Integration of a web processing service (WPS), GIS and hydraulic modelling (TELEMAC) for geophysical analysis." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2003399/.
Повний текст джерелаJohansson, Wilhelm. "Modeling of Wet Scrubber with Heat Recovery in Biomass Combustion Plants." Thesis, Linnéuniversitetet, Institutionen för byggd miljö och energiteknik (BET), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-95585.
Повний текст джерелаMontoliu, Álvaro Carles. "Study, Modelling and Implementation of the Level Set Method Used in Micromachining Processes." Doctoral thesis, Universitat Politècnica de València, 2015. http://hdl.handle.net/10251/58609.
Повний текст джерела[ES] El tema principal de la presente tesis consiste en mejorar la simulación de los procesos de fabricación utilizando el método Level Set (LS). El LS es una técnica matemática utilizada para la evolución de frentes según un movimiento definido por unas leyes. La principal ventaja de este método es que el frente está embebido dentro de una función definida en una dimensión superior. Actualizar dicha función en lugar del propio frente permite tratar de forma trivial situaciones complejas como la separación o la colisión de diversos frentes. En concreto, este documento se centra en los procesos de atacado húmedo y seco, los cuales son ampliamente utilizados en el proceso de fabricación de Sistemas Micro-Electro-Mecánicos (MEMS, de sus siglas en inglés). Un MEMS es un sistema formado por elementos mecánicos, sensores, actuadores y electrónica. Estos dispositivos hoy en día son utilizados en muchos campos de la industria como la seguridad automovilística, sensores de movimiento y teléfonos inteligentes. El proceso de atacado húmedo consiste en eliminar de forma selectiva el material del sustrato (por ejemplo, silicio o cuarzo) con una solución líquida con el fin de formar una estructura específica. Éste es un proceso complejo pues el resultado depende de muchos factores, tales como la estructura cristalográfica del material, la solución atacante o su temperatura. De forma similar, los procesos de atacado seco son utilizados para eliminar el material del sustrato, sin embargo, se utilizan sustancias gaseosas en la fase de atacado. En ambos casos, la utilización de un simulador capaz de predecir de forma precisa el resultado de un experimento concreto implicaría una reducción significativa del tiempo de diseño y de los costes. Existen unos pocos simuladores del proceso de atacado húmedo basados en el método LS, no obstante tienen muchas limitaciones y nunca han sido validados con experimentos reales. Por otro lado, los simuladores atomísticos son hoy en día considerados los simuladores más avanzados pero tienen algunos inconvenientes como la necesidad de un proceso de calibración previo para poder utilizar los datos experimentales. Además, debe invertirse mucho esfuerzo para crear un modelo atomístico para la simulación de materiales de sustrato con distintas estructuras atomísticas. Asimismo, el resultado final siempre está formado por átomos inconexos que dificultan una correcta visualización y un correcto entendimiento de aquellas estructuras complejas, por tanto, normalmente debe emplearse una técnica adicional para la visualización de dichos resultados. Por su parte, los simuladores del proceso de atacado seco normalmente utilizan técnicas de representación explícita para evolucionar, según los modelos de atacado, la superficie que está siendo atacada. Esta técnica puede producir resultados poco realistas, sobre todo en situaciones complejas como la interacción de múltiples superficies. A pesar de que unos pocos modelos son capaces de solventar estos problemas, nunca han sido comparados con experimentos reales ni el rendimiento computacional de las correspondientes implementaciones ha sido adecuadamente analizado. Las expuestas limitaciones son abordadas en la presente tesis y se han producido las siguientes contribuciones: - Implementación eficiente del método LS para mejorar la representación visual de los simuladores atomísticos del proceso de atacado húmedo. - Definición de un nuevo modelo basado en el LS que pueda usar directamente los datos experimentales de muchos atacantes para simular el proceso de atacado húmedo de diversos materiales de sustrato. - Validación del simulador comparándolo con resultados experimentales y con los de simuladores atomísticos. - Implementación de una herramienta basada en el método LS que evolucione la superficie que está siendo atacada según los modelos de atacado seco para habilitar la simulación de procesos comple
[CAT] El tema principal de la present tesi consisteix en millorar la simulació de processos de fabricació mitjançant el mètode Level Set (LS). El LS és una tècnica matemàtica utilitzada per a l'evolució de fronts segons un moviment definit per unes lleis en concret. El principal avantatge d'aquest mètode és que el front està embegut dins d'una funció definida en una dimensió superior. D'aquesta forma, actualitzar la dita funció en lloc del propi front, permet tractar de forma trivial situacions complexes com la separació o la col·lisió de diversos fronts. En concret, aquest document es centra en els processos d'atacat humit i sec, els quals són àmpliament utilitzats en el procés de fabricació de Sistemes Micro-Electro-Mecànics (MEMS, de les sigles en anglès). Un MEMS és un sistema format per elements mecànics, sensors, actuadors i electrònica. Aquests dispositius han guanyat molta popularitat en les últimes dècades i són utilitzats en molts camps de la indústria, com la seguretat automobilística, sensors de moviment i telèfons intel·ligents. El procés d'atacat humit consisteix en eliminar de forma selectiva el material del substrat (per exemple, silici o quars) amb una solució líquida, amb la finalitat de formar una estructura específica. Aquest és un procés complex ja que el resultat de un determinat experiment depèn de molts factors, com l'estructura cristal·logràfica del material, la solució atacant o la seva temperatura. De manera similar, els processos d'atacat sec son utilitzats per a eliminar el material del substrat, no obstant, s'utilitzen substàncies gasoses en la fase d'atacat. En ambdós casos, la utilització d'un simulador capaç de predir de forma precisa el resultat d'un experiment en concret implicaria una reducció significativa del temps de disseny i dels costos. Existeixen uns pocs simuladors del procés d'atacat humit basats en el mètode LS, no obstant tenen moltes limitacions i mai han sigut validats amb experiments reals. Per la seva part, els simuladors atomístics tenen alguns inconvenients com la necessitat d'un procés de calibratge previ per a poder utilitzar les dades experimentals. A més, deu invertir-se molt d'esforç per crear un model atomístic per a la simulació de materials de substrat amb diferents estructures atomístiques. Així mateix, el resultat final sempre està format per àtoms inconnexos que dificulten una correcta visualització i un correcte enteniment d'aquelles estructures complexes, per tant, normalment deu emprar-se una tècnica addicional per a la visualització d'aquests resultats. D'altra banda, els simuladors del procés d'atacat sec normalment utilitzen tècniques de representació explícita per evolucionar, segons els models d'atacat, la superfície que està sent atacada. Aquesta tècnica pot introduir resultats poc realistes, sobretot en situacions complexes com per exemple la interacció de múltiples superfícies. A pesar que uns pocs models son capaços de resoldre aquests problemes, mai han sigut comparats amb experiments reals ni tampoc el rendiment computacional de les corresponents implementacions ha sigut adequadament analitzat. Les exposades limitacions son abordades en els diferents capítols de la present tesi i s'han produït les següents contribucions: - Implementació eficient del mètode LS per millorar la representació visual dels simuladors atomístics del procés d'atacat humit. - Definició d'un nou model basat en el mètode LS que puga utilitzar directament les dades experimentals de molts atacants per a simular el procés d'atacat humit de diversos materials de substrat. - Validació del simulador d'atacat humit desenvolupat comparant-lo amb resultats experimentals i amb els de simuladors atomístics. - Implementació d'una ferramenta basada en el mètode LS que evolucione la superfície que està sent atacada segons els models d'atacat sec per, d'aquesta forma, habilitar la simulació de processo
Montoliu Álvaro, C. (2015). Study, Modelling and Implementation of the Level Set Method Used in Micromachining Processes [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/58609
TESIS
Brown, Andrew Gavin. "Measurement and modelling of combustion in a spark ignition engine." Thesis, Brunel University, 1991. http://bura.brunel.ac.uk/handle/2438/5143.
Повний текст джерелаLobosco, Vinicius. "On the Modelling of Mechanical Dewatering in Papermaking." Doctoral thesis, KTH, Fibre and Polymer Technology, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3702.
Повний текст джерелаMost of the water fed into a paper machine is removedmechanically in the forming and press sections. One of thefactor which has an important influence on mechanicaldewatering, i.e. in both forming and pressing, is thestress-strain behaviour of the fibre network.
The focus of this thesis is on the development of improvedmathematical descriptions of the stress-strain behaviourexhibited by fibre networks in the forming and press sections.The first part of the thesis presents a physically based modelof the forming and densification of fibre mats in twin-wireformers. The model can calculate the ecect of the applicationof a varied load through the forming section. It was developedfrom mass and momentum balances of the fibre and liquid phases,the fibre mat stress-porosity relation and an expression forthe permeability as a function of the porosity. The fibre-matstress-porosity relation used is rate-independent and presentshysteresis. Simulations have been conducted to study theeffects of roll pressure, blade pulses, wire tension andbeating. The effect of sequential blade pressure pulses afterthe forming roll on the dewatering and the concentrationgradients could be characterised. The simulations alsoexhibited rewetting by expansion when the fibre mats left theforming roll. Increasing wire tension resulted in increaseddewatering, but the rate of increase diminished rapidly withincreasing tension. The simulation results also indicated thatbeating has a large influence on dewatering.
The second part of the thesis presents two models of therate-dependent stress-strain behaviour of the fibre networkthat is observed in wet pressing. The first model was based onthe approach pioneered by Perzyna (1966) for strain-ratedependent plasticity and was quite satisfactory for calculatingthe stress-strain behaviour of the fibre network in singlepress nips. It was successfully applied for studyingdensification and dewatering in both normal wet pressing andhigh temperature wet pressing. However, the first model onlyincludes rate dependence in the compression phase of thecompressionexpansion cycle; the expansion phase is treated asbeing rate independent
The second model of the stress-strain behaviour of the fibrenetwork treats both compression and expansion as being ratedependent, according to experimental observations. It is basedon the idea that the wet fibre web may be conceived as alayered network of restricted swelling gels. A swollen fibre isa restricted gel, the inner swelling pressure in a swollenfibre wall being balanced by the stresses in the fibre wallstructure. The observed rate dependence of wet webs in bothcompression and expansion phases was attributed to the flow ofwater out of and into the fibre walls. The second model gavepredictions that are in good agreement with results fromuniaxial experiments using pressure pulses of arbitrary shapefor both a single pulse and a sequence of pulses. It maytherefore be used as a general model for the rheologicalbehaviour of the wet fibre network in wet pressing, providedthe model parameters are estimated from experimental data withsmall experimental error.
KEYWORDS:Paper, modelling, dewatering, forming, wetpressing, fibre network stress, rheology, hysteresis,intra-fibre water, compressibility, structural stress,stress-strain, restricted gels, swelling.
Williamson, Nicholas J. "Numerical modelling of heat and mass transfer and optimisation of a natural draft wet cooling tower." University of Sydney, 2007. http://hdl.handle.net/2123/4123.
Повний текст джерелаThe main contribution of this work is to answer several important questions relating to natural draft wet cooling tower (NDWCT) modelling, design and optimisation. Specifically, the work aims to conduct a detailed analysis of the heat and mass transfer processes in a NDWCT, to determine how significant the radial non-uniformity of heat and mass transfer across a NDWCT is, what the underlying causes of the non-uniformity are and how these influence tower performance. Secondly, the work aims to determine what are the consequences of this non-uniformity for the traditional one dimensional design methods, which neglect any two-dimensional air flow or heat transfer effects. Finally, in the context of radial non-uniformity of heat and mass transfer, this work aims to determine the optimal arrangement of fill depth and water distribution across a NDWCT and to quantify the improvement in tower performance using this non-uniform distribution. To this end, an axisymmetric numerical model of a NDWCT has been developed. A study was conducted testing the influence of key design and operating parameters. The results show that in most cases the air flow is quite uniform across the tower due to the significant flow restriction through the fill and spray zone regions. There can be considerable radial non-uniformity of heat transfer and water outlet temperature in spite of this. This is largely due to the cooling load in the rain zone and the radial air flow there. High radial non-uniformity of heat transfer can be expected when the cooling load in the rain zone is high. Such a situation can arise with small droplet sizes, low fill depths, high water flow rates. The results show that the effect of tower inlet height on radial non-uniformity is surprisingly very small. Of the parameters considered the water mass flow rate and droplet size and droplet distribution in the rain zone have the most influence on radial noniv uniformity of heat transfer. The predictions of the axisymmetric numerical model have been compared with a one dimensional NDWCT model. The difference between the predictions of tower cooling range is very low, generally around 1-2%. This extraordinarily close comparison supports the assumptions of one dimensional flow and bulk averaged heat transfer implicit in these models. Under the range of parameters tested here the difference between the CFD models predictions and those of the one dimensional models remained fairly constant suggesting that there is no particular area where the flow/heat transfer becomes so skewed or non-uniform that the one dimensional model predictions begin to fail. An extended one dimensional model, with semi-two dimensional capability, has been developed for use with an evolutionary optimisation algorithm. The two dimensional characteristics are represented through a radial profile of the air enthalpy at the fill inlet which has been derived from the CFD results. The resulting optimal shape redistributes the fill volume from the tower centre to the outer regions near the tower inlet. The water flow rate is also increased here as expected, to balance the cooling load across the tower, making use of the cooler air near the inlet. The improvement has been shown to be very small however. The work demonstrates that, contrary to common belief, the potential improvement from multi-dimensional optimisation is actually quite small.
Williamson, N. J. "Numerical modelling of heat and mass transfer and optimisation of a natural draft wet cooling tower." Connect to full text, 2008. http://ses.library.usyd.edu.au/handle/2123/4035.
Повний текст джерелаTitle from title screen (viewed February 12, 2009). Includes graphs and tables. Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Aerospace, Mechanical and Mechatronic Engineering. Includes bibliographical references. Also available in print form.
Williamson, Nicholas J. "Numerical modelling of heat and mass transfer and optimisation of a natural draft wet cooling tower." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/4123.
Повний текст джерелаWilliamson, Nicholas J. "Numerical modelling of heat and mass transfer and optimisation of a natural draft wet cooling tower." Phd thesis, School of Aerospace, Mechanical and Mechatronic Engineering, 2008. http://hdl.handle.net/2123/4035.
Повний текст джерелаHossain, Firoz, and Abu-Shadat-Mohammad Sohab. "Mathematical Modelling of Call Admission Control in WCDMA Network." Thesis, Blekinge Tekniska Högskola, Avdelningen för signalbehandling, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-2933.
Повний текст джерелаLeyva, Mendivil Maria. "Development of a multi-physics modelling framework to characterise the interactions of skin and wet shaving products." Thesis, University of Southampton, 2016. https://eprints.soton.ac.uk/394280/.
Повний текст джерелаRobson, Joseph Douglas. "Modelling of carbide and Laves phase precipitation in 9-12 wt% chromium steels." Thesis, University of Cambridge, 1997. https://www.repository.cam.ac.uk/handle/1810/224753.
Повний текст джерелаZaccarelli, Riccardo. "Mathematical modelling of sound production in birds." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/16507.
Повний текст джерелаIn this thesis, the physics of birds phonation is discussed using a two-mass models approach and the theory of nonlinear dynamics. Two-mass models of the human larynx (rescaled two-mass model and trapezoidal model) have been adapted to the dimension of the avian syrinx to study pressure onset, control of harmonic overtones and "registers" of the sound radiated by the birds vocal organ (syrinx) in the absence of source-tract coupling. Our simulations are a first step towards more realistic modelling of the syrinx. A detailed bifurcation analysis of the trapezoidal model confirms that the geometry and the rest position of the syrinx can influence the harmonic spectra drastically, suggests possible mechanisms involved in the production of rich-harmonic spectra during inspiration and is used to describe quantitatively the contribution of syringeal muscles. The latter is implemented in the model by means of driving time-dependent parameters controlling the labia rest position and frequency modulation.
Ali, Hassan. "Improvement of centrifugal wet scrubber design through laboratory experimentation and computational fluid dynamics." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/112479/2/Hassan%20Ali%20Thesis.pdf.
Повний текст джерелаGRAZIOLI, PAOLO. "IN VITRO AND IN VIVO MODELLING OF CORNELIA DE LANGE SYNDROME CAUSATIVE MUTATIONS: WNT ACTIVATION AS A POSSIBLE THERAPEUTIC APPROACH." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/821677.
Повний текст джерелаCornelia de Lange Syndrome (CdLS) is a rare genetic disorder affecting almost any organ including the central nervous system, inducing a variable neurodevelopmental delay. CdLS malformations derive from mutations in cohesin complex genes (protein complex involved in the cohesion control of sister chromatids) and deregulation of developmental pathways, inclusive of the canonical WNT pathway, which results less active. In order to ameliorate the phenotype, I have explored possible ameliorative effects of the canonical WNT pathway chemical activation using lithium in two different models: human induced pluripotent stem cells (hiPSCs) and Drosophila melanogaster. For mimicking cohesins haploinsufficiency, hiPSCs differentiated in neural precursor cells (hNPC) were treated with a specific HDAC8 inhibitor, protein known to be implicated in CdLS pathogenesis. Upon treatment with lithium chloride, cells showed improved differentiation capabilities through the neuronal lineage. Drosophila melanogaster adults carrying a loss-of-function allele in a cohesins gene and reared on food supplemented with lithium as activator of canonical WNT pathway, showed a significant rescue in mushroom bodies morphology, a central nervous system structure important for the olfactory learning and memory. This PhD project’s results further support the hypothesis that disruption in canonical WNT pathway, caused by cohesins mutations, plays a central role in CdLS etiopathogenesis. This theory is corroborated by the consistent phenotype rescue by lithium administration in experimental models, paving the way for new possible and urgently needed therapeutic strategies.
Barnard, Nicholas. "Modelling the localized corrosion effects experienced by electroplated zinc and zinc-4.5 wt.% aluminium steel coatings." Thesis, Swansea University, 2006. https://cronfa.swan.ac.uk/Record/cronfa42335.
Повний текст джерелаAlexandersson, Evelina. "NÄR SAMVERKAN ÄR LÖSNINGEN - En diskursanalys enligt WPR-modellen av statens syn på samverkan kring barn och unga." Thesis, Malmö universitet, Fakulteten för kultur och samhälle (KS), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-23806.
Повний текст джерелаSeco, Raquel Irene. "In-sewer organic sediment transport : study of the release of sediments during wet-weather from combined sewer systems in the Mediterranean region in Spain." Doctoral thesis, Universitat Politècnica de Catalunya, 2014. http://hdl.handle.net/10803/284586.
Повний текст джерелаLos depósitos de sedimentos en sistemas unitarios de alcantarillado pueden dar lugar a importantes problemas de calidad de aguas, muchas veces ignorados. La acumulación de sedimentos en estos sistemas puede generar el aumento en la frecuencia de vertidos a medios naturales receptores durante una tormenta. La presencia de sólidos de origen orgánico en los vertidos de aguas sin tratar puede producir impactos perjudiciales en las aguas receptoras. Los medioambientes acuáticos son afectados principalmente por las altas demandas de oxígeno y las contribuciones de nitrógeno originados en los sedimentos orgánicos. Este estudio se centra en los procesos de re-suspensión de sedimentos altamente orgánicos que se han acumulado en las redes de alcantarillado unitario. Luego de largos períodos secos típicos en la región Mediterránea, los depósitos de sedimentos son re-movilizados y transportados a través del sistema por la escorrentía producida por una tormenta. El objetivo de la investigación es desarrollar una metodología que sea capaz de predecir el potencial de erosión y posterior movilización de los sedimentos orgánicos a través del sistema. Para ello, es necesario mejorar el conocimiento que se tiene sobre los procesos que ocurren durante largos períodos sin lluvias y analizar las variables involucradas que puedan influir en la erosión de los depósitos. Contar con la disponibilidad de datos de campo confiables es esencial en el logro de resultados válido en un modelo de calidad de aguas. Muestras de sedimento no homogéneo y altamente orgánico se recogieron en un sistema de alcantarillado unitario. A través de ensayos en laboratorio, estos sedimentos se utilizaron para la evaluación de sus características y comportamiento vinculado a la erosión. La introducción en el modelo de una ley de tensión crítica de arrastre más realista permite una mejor representación de la movilización de los sedimentos. Los resultados obtenidos muestran que la predicción del transporte de sedimentos orgánicos de alcantarillado es posible de realizar aunque es un tema muy complejo. Mayores esfuerzos son aún necesarios para lograr la transferencia directa de los resultados para una aplicación más generalizada del modelo predictivo obtenido. Una de las principales contribuciones de esta investigación está vinculada al logro de un conocimiento más detallado de la estructura de los depósitos de sedimento orgánico en relación a su resistencia a la erosión. El conocimiento adquirido podría ser aplicado en la mejora en las predicciones de cargas contaminantes que llegan a cursos de agua naturales durante vertidos. Todo ello, siguiendo como objetivo final, la protección de las aguas naturales receptoras.
Mukepe, Kahilu Moise. "Identification and control of wet grinding processes: application to the Kolwezi concentrator." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209562.
Повний текст джерелаThe present thesis focuses on an industrial application, namely the Kolwezi concentrator (KZC) double closed-loop wet grinding circuit. As any industrial wet grinding process, this process offers complex and challenging control problems due to its configuration and to the requirements on the product characteristics. In particular, we are interested in the modelling of the process and in proposing a control strategy to maximize the product flow rate while meeting requirements on the product fineness and density.
A mathematical model of each component of the circuit is derived. Globally, the KZC grinding process is described by a dynamic nonlinear distributed parameter model. Within this model, we propose a mathematical description to exhibit the increase of the breakage efficiency in wet operating condition. In addition, a relationship is proposed to link the convection velocity to the feed ore rate for material transport within the mills.
All the individual models are identified from measurements taken under normal process operation or from data obtained through new specific experiments, notably using the G41 foaming as a tracer to determine material transport dynamics within the mills. This technique provides satisfactory results compared to previous studies.
Based on the modelling and the circuit configuration, both steady-state and dynamic simulators are developed. The simulation results are found to be in agreement with the experimental data. These simulation tools should allow operator training and they are used to analyse the system and to design the suitable control strategy.
As the KZC wet grinding process is a Multi-Input Multi-Output (MIMO) system, we propose a decentralized control scheme for its simplicity of implementation. To overcome all the control issues, a Double Internal Model Control (DIMC) scheme is proposed. This strategy is a feedforward-feedback structure based on the use of both a modified Disturbance Observer (DOB) and a Proportional-Integral Smith-Predictor (PI-SP). A duality between the DOB and PI-SP is demonstrated in design method. The latter is exploited to significantly simplify the design procedure. The designed decentralized controllers are validated in simulation on the process linearized model. A progressive implementation of the control strategy is proposed in the context of the KZC grinding circuit where instrumentation might not be obvious to acquire./
Améliorer les techniques de traitement de minerais est un défi permanent dans l'industrie des minéraux et des métaux. En effet, pour satisfaire aux exigences du produit fini (métal ) fixées par le marché de consommation, la commande automatique est souvent appliquée à l'usine du traitement de minerais dont le produit, le concentré, constitue la matière première de la métallurgie extractive. Une attention particulière est donc dévolue aux unités de traitement de minerais et en particulier aux concentrateurs. Comme le processus de réduction des dimensions granulométriques du minerai est l'étape critique d'un concentrateur, il s'avère que la commande d'un circuit de broyage est cruciale, car ce stade représente près de 50 % des dépenses totales de l' usine de concentration. De plus, la dimension granulométrique du produit de l'étape de broyage influe sur le taux de récupération des minéraux utiles ainsi que sur le volume des rejets du processus ultérieur.
La présente thèse porte sur une application industrielle, à savoir le concentrateur de Kolwezi (KZC qui est un circuit de broyage humide à double boucle fermée. Comme tout processus industriel de broyage humide, ce procédé présente une problématique de commande complexe et difficile en raison de sa configuration et des exigences relatives aux caractéristiques du produit. En particulier, nous nous intéressons à la modélisation de ce procédé et à proposer une stratégie adéquate de commande dans le but de maximiser le débit de production tout en respectant les exigences quant à la finesse et à la densité de la pulpe produite.
Un modèle mathématique de chaque composant du circuit a été déterminé. Globalement, le processus de broyage de KZC est décrit par un modèle dynamique non linéaire à paramètres distribués. Dans ce modèle, une description mathématique de l'augmentation de l'efficacité du broyage en milieu humide est proposée. En outre, nous avons proposé une relation liant la vitesse de convection au débit d'alimentation de minerais dans le modèle du transport de la matière à l'intérieur des broyeurs.
Tous les modèles mathématiques ont été identifiés à partir de mesures prises sur le procédé en fonctionnement d'équilibre stable ou à partir des données obtenues grâce à des nouvelles expériences spécifiques, notamment en utilisant le moussant G41 comme traceur pour déterminer la dynamique de transport de la matière dans les broyeurs. Cette technique a produit des résultats cohérents par rapport aux études antérieurs réalisées au moyen du traceur colorant ou radioactif.
Les simulateurs statique et dynamique ont été développés sur la base de la modélisation mathématique et de la configuration du circuit. Les résultats des simulations sont en accord avec les données expérimentales. Ces outils de simulation devraient permettre la formation des opérateurs et ont été utilisés pour analyser le système et concevoir la stratégie de commande la plus appropriée.
Comme le processus de broyage humide de KZC est un système à plusieurs grandeurs d'entrée et plusieurs grandeurs de sortie, nous avons proposé une structure de commande décentralisée en raison de sa simplicité de mise en œuvre .Afin de surmonter tous les problèmes de commande, un schéma de commande à double modèle interne (CDMI) est proposée. Cette stratégie est une structure à anticipation - rétroaction basée sur l'utilisation d'un observateur de perturbations (OBP) et d'un Prédicteur de Smith doté d'un régulateur Proportionnel-Intégral (PS-PI). Une dualité entre l'OBP et le PS-PI est démontrée dans la méthode de conception. Cette propriété est exploitée pour simplifier considérablement la procédure de conception. Les régulateurs décentralisés ainsi conçus sont validés en simulation sur le modèle linéarisé du procédé. Une mise en œuvre progressive de la stratégie de commande est proposée dans le contexte du circuit de broyage de KZC où l'instrumentation peut ne pas être évidente à acquérir.
Doctorat en Sciences de l'ingénieur
info:eu-repo/semantics/nonPublished
Gallet, Emmanuelle. "Techniques de model-checking pour l’inférence de paramètres et l’analyse de réseaux biologiques." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLC035/document.
Повний текст джерелаIn this thesis, we present the use of model checking techniques for inference of parameters of Gene Regulatory Networks (GRNs) and formal analysis of a signalling pathway. In the first and main part, we provide an approach to infer biological parameters governing the dynamics of discrete models of GRNs. GRNs are encoded in the form of a meta-model, called Parametric GRN, such that a parameter instance defines a discrete model of the original GRN. Provided that targeted biological properties are expressed in the form of LTL formulas, LTL model-checking techniques are combined with symbolic execution and constraint solving techniques to select discrete models satisfying these properties. The challenge is to prevent combinatorial explosion in terms of size and number of discrete models. Our method is implemented in Java, in a tool called SPuTNIk. The second part describes a work performed in collaboration with child neurologists, who aim to understand the occurrence of toxic or protective phenotype of microglia (a type of macrophage in the brain) in the case of preemies. We use an other type of model-checking, the statistical model-checking, to study a particular type of biological network: the Wnt/β- catenin pathway that transmits an external signal into the cells via a cascade of biochemical reactions. Here we present the benefit of the stochastic model checker COSMOS, using the Hybrid Automata Stochastic Logic (HASL), that is an very expressive formalism allowing a sophisticated formal analysis of the dynamics of the Wnt/β-catenin pathway, modelled as a discrete event stochastic process
Gong, Li. "Selective external oxidation of Fe-Mn (1 wt.%) binary alloys during continuous annealing." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASC014.
Повний текст джерелаThis work is focused on the selective oxidation behavior of Fe-Mn (1 wt.%) binary alloy during continuous annealing under the industrial galvanizing conditions, to understand the diffusion of manganese and oxygen and the mechanism oxide formation on the surface.An analytical model was first developed to describe the surface reactions and thermodynamics involving water vapor and diffusion of O and Mn in the alloy, and the heterogeneous nucleation and growth of MnO oxides on the surface. Theoretical equations were established and sovled to calculate the critical radius and nucleation rate of MnO embryos and the size and surface coverage fractions of MnO oxides as a function of annealing.Annealing experiments were then conducted and the annealed surfaces were analyzed by: EBSD maps to determine the ferrite grain orientation; EDS analysis to determine the chemical nature; SEM and AFM to study the geometrical characteristics of oxides; TEM/STEM on the crosee-sections to observe the lateral shape of oxides; XPS to study the oxide nature and Mn concentration profiles as a function of depth and diffraction patterns to determine the orientation relationship of MnO and ferrite substrate.Wulffmaker software was used to simulate the equilibrium crystal of MnO. Observations by SEM, AFM and TEM/STEM make it possible to realize the facets composing MnO crystals
Lousteau, Cédric. "Conversion de la pollution ammoniacale en azote moléculaire par Oxydation en Voie Humide Catalytique (OVHC)." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10182/document.
Повний текст джерелаTiO2, ZrO2, CeO2 and CeZrO2 supported noble metal catalysts (Pt, Pd, Ir, Ru and Rh) have been in a first time prepared to be used in the Catalytic Wet Air Oxidation of ammonia. The first results show that platinum is the most active metal. Palladium and iridium are the most selective toward nitrogen. Pt/TiO2 is the most interesting catalyst because it combines a very strong activity and a selectivity toward nitrogen close to iridium and palladium. An in-depth study on this catalyst (preparation method, nature of the metallic precursor…) shows that the single parameter which has a negative impact on the selectivity toward nitrogen is the basicity of the catalyst surface. The work realized on the operating conditions (PO2, catalyst weight, pH and ammonia concentration) in the presence of Pt/TiO2 shows the necessity to control the oxidizing function and particularly the nO2/nNH3 ratio. Indeed, if the value of this ratio is too high (nO2/nNH3 >> 0,75) then the selectivity toward nitrogen degrades strongly. To end, PtIr/TiO2 and PtPd/TiO2 bimetallic catalysts have been prepared to combine the activity of the platinum and the selectivity of palladium/iridium to nitrogen. These catalysts are not interesting because their behaviour is similar to the mechanical mixtures. Furthermore, the selectivity toward nitrogen is also degraded for nO2/nNH3 >> 0,75 with these catalysts
Nachev, Vladislav Nikolaev. "Cognition mediated floral evolution." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://dx.doi.org/10.18452/16869.
Повний текст джерелаA diverse array of animals has specialized in consuming floral nectar – from butterflies and bees to hummingbirds and bats. The nectar characteristics of plant species often appear to reflect the needs of their dominant pollinator, for example plants pollinated by larger animals tend to produce larger amounts of nectar. This correspondence suggests that nectar traits have evolved in response to the choice behavior of pollinators. The evolutionary and ecological interaction between plants and their pollinators crucially depends on the pollinators’ ability to perceive differences in floral nectar traits and on their decision-making mechanisms. In the presented studies I adopt a cognitive ecology approach in order to investigate the role of information-processing in pollinators on the evolution of floral nectar traits. In the first three chapters I focus on the abilities of different pollinators to discriminate among sugar solutions with different concentrations. In Chapter 4 I present a detailed analysis of individual differences in the foraging context and discuss how they might relate to foraging efficiency. In the fifth and final chapter I use the findings on the psychophysics of nectar quality evaluation to address the question of the evolutionary origins of floral nectar traits. With these studies I show how the investigation of cognitive mechanisms of pollinators can inform evolutionary and ecological research on plants pollinated by animals. In addition, I demonstrate how the virtual pollination ecology methodology can explain the evolutionary origin and maintenance of plant traits that are subjected to cognition-mediated selection exerted by pollinators.
Kay, Sophie Kate. "Cell fate mechanisms in colorectal cancer." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:f19bf73d-0c0e-4fff-9589-bf43f9ff12f0.
Повний текст джерелаGaluška, Jiří. "Modelování vtokových vírů." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2017. http://www.nusl.cz/ntk/nusl-318713.
Повний текст джерелаHamit-Haggar, Mahamat. "Essays on environmental and development economics." Thesis, Université Clermont Auvergne (2017-2020), 2018. http://www.theses.fr/2018CLFAD005/document.
Повний текст джерелаThis thesis comprises four empirical essays on environmental and development economics. In the first chapter, we examine to what extent individual and contextual level factors influence individuals to contribute financially to prevent environmental pollution. We find that rich people, individuals with higher education, as well as those who possess post-materialist values are more likely to be concerned about environmental pollution. We also observe the country in which individuals live matter in their willingness to contribute. More precisely, we find democracy and government stability reduce individuals’ intention to donate to prevent environmental damage mainly in developed countries. The second chapter deals with the relation between economic growth and environmental degradation by focusing on the issue of whether the inverted U-shaped relation exist. The study discloses no evidence for the U-shaped relation. However, the empirical result points toward a non-linear relationship between environmental degradation and economic growth, that is, emissions tend to rise rapidly in the early stages with economic growth, and then emissions continue to increase but a lower rate in the later stages. The third chapter investigates the long-run as well as the causal relationship between energy consumption and economic growth in a group of Sub-Saharan Africa. The result discovers the existence of a long-run equilibrium relationship between clean energy consumption and economic growth. Furthermore, the short-run and the long-run dynamics indicate unidirectional Granger causality running from clean energy consumption to economic growth without any feedback effects. The last chapter of this thesis concerns with convergence of emissions across Canadian provinces. The study determines convergence clubs better characterizes Canadian’s emissions. In other words, we detect the existence of segmentation in emissions across Canadian provinces
Barata, Miguel Guerreiro. "Modelling a fluidized wet granulation process." Master's thesis, 2020. http://hdl.handle.net/10451/52480.
Повний текст джерелаTradicionalmente, a produção de medicamentos pela indústria farmacêutica é realizada em modo descontínuo sendo o produto acabado libertado após a sua verificação, também designado por quality-by-testing. Este fato decorre em parte devido ao elevado nível de regulação, o que, no passado, juntamente com outros fatores, dificultou a transição para processos contínuos e novos paradigmas de avaliação da qualidade. Atualmente, a transição para processos de produção em contínuo começou a ser incentivada pelas autoridades reguladoras, sendo que estes processos serão vantajosos não só para a indústria, por aumentar a eficiência dos processos de produção, mas também para os consumidores, fornecendo uma maior consistência na qualidade dos produtos fabricados. A Food and Drug Administration (FDA) e a European Medicines Agency (EMA), assim como as novas guidelines do Conselho Internacional para Harmonização de Requisitos Técnicos de Produtos Farmacêuticos para Uso Humano (ICH). incentivam agora o desenvolvimento de processos de produção de medicamentos baseados no conceito de Quality-By-Design (QbD). Permitindo implementar processos contínuos de produção baseando-se num conhecimento aprofundado das principais variáveis que influenciam o processo de fabrico, de forma a conceber um produto de qualidade e, tendo em conta que a qualidade não deve ser testada no produto final, mas sim desenvolvida desde a primeira etapa de produção. Com o conceito de QbD em mente, foi decidido, neste estudo, desenvolver um design space (DS) para um processo de granulação, uma vez que se trata de um processo importante na produção de várias formas farmacêuticas. Para isso, estudou-se uma combinação de variáveis e parâmetros do processo que demostram resultar num produto de qualidade, ou seja, dentro das especificações que foram estabelecidas. As variáveis escolhidas para este estudo incluíram a formulação e parâmetros identificados como críticos do processo. Para alcançar este objetivo, foi utilizado um método de delineamento experimental de forma a definir os ensaios a realizar. Os grânulos foram testados de acordo com vários parâmetros de qualidade de forma a estabelecer o DS. De modo a testar a influência do processo de granulação na forma farmacêutica final, foi decidido também proceder à produção de comprimidos, que foram também testados.
Traditionally the production of medicines by the pharmaceutical industry is done in batches with the finished product released after verification, also known as quality-by-testing. This is due to the fact that it is an industry with tight regulations that, in the past, together with other factors, made the transition to continuous processes, as well as quality control methods difficult. Currently, the transition to continuous processes has been encouraged by regulatory authorities as these processes will be advantageous not only for the industry, as it increases the efficiency of the processes, but also for the consumers, providing higher quality to the manufactured product. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), as well as the new guidelines from the International Council for Harmonization of Technical Requirements for Pharmaceutical Products for Human Use (ICH) now encourage the development of drug manufacturing processes based on the concept of quality-bydesign(QbD), with the opportunity of implementing continuous production processes based on an in-depth knowledge of the main variables that influence the manufacturing process, in order to design a quality product, with the notion that quality cannot be tested on a product but developed from the ground up starting with the first step of production. With the concept of QbD in mind, it was decided, in this study, to develop a design space (DS) for a granulation process, an important process in the production of various pharmaceutical forms, studying a combination of variables and process parameters that guarantee to result in a product with quality, that is, within the specifications that were decided. The variables chosen for this process included the formulation and critical parameters of the process. To achieve this objective, experimental design was used in order to establish the most important tests. The granules were tested in various experiments suitable to our variables in order to establish the DS. In order to test the influence of the granulation process on the final pharmaceutical form, it was also decided to proceed with the production of tablets, which were also tested.
Com o patrocínio da Faculdade de Farmácia da Universidade de Lisboa.
Oskarsson, Peter. "Evaporator modelling under conditions of dry, wet, and frosted finned surfaces." Thesis, 1988. http://spectrum.library.concordia.ca/3204/1/ML44852.pdf.
Повний текст джерелаYan-Chung, Cheng, and 鄭淵中. "Preliminary Investigation on Measuring and Modelling the dynamic Wave Velocities for Wet Soils." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/75782465976789217074.
Повний текст джерела淡江大學
土木工程研究所
83
Effects of the degree of saturation and void ratio on dynamic wave velocities of the wet soils are investigated with both theoretical and experimented studies in this research. Analytical three-phase models are derived from the Wood equation (Wood, 1930) using alternative postulates. Pore pressure parameters are considered in the two-phase models which consists of the soil solids and the pore fluid. With stress/strain homogeneity and strain decomposition or consistent strain definitions, different models can be derived. Parametric study is conduced in comparison with the laboratory result. It is found that the two-phase models in general provide better solutions than the three-phase models. The dynamic wave velocity which corresponds to the compressive wave is very sensitive to the air intrusion when nearly saturated. The shear wave velocity is indeed less affected by the degree of saturation. And they are found gradually increased by increasing the percentage of fine grains in the soils.
Moura, Tânia Catarina Pinto. "Modelling of wet air oxidation in a deep well reactor for biomass treatment." Master's thesis, 2021. https://hdl.handle.net/10216/136931.
Повний текст джерелаKlimanek, Adam. "Numerical modelling of heat, mass and momentum transfer in natural draft wet-cooling tower." Rozprawa doktorska, 2009. https://repolis.bg.polsl.pl/dlibra/docmetadata?showContent=true&id=8038.
Повний текст джерелаKlimanek, Adam. "Numerical modelling of heat, mass and momentum transfer in natural draft wet-cooling tower." Rozprawa doktorska, 2009. https://delibra.bg.polsl.pl/dlibra/docmetadata?showContent=true&id=8038.
Повний текст джерелаMakokha, Augustine Barasa. "Measuring, characterisation and modelling of load dynamic behaviour in a wet overflow-discharge ball mill." Thesis, 2012. http://hdl.handle.net/10539/11180.
Повний текст джерелаSerra, Carlos Luís de Oliveira Macedo. "Prediction of dam concrete structural properties based on wet-screened test results and mesoscale modelling." Doctoral thesis, 2017. http://hdl.handle.net/10362/31247.
Повний текст джерела"Multi-Unit Longitudinal Models with Random Coefficients and Patterned Correlation Structure: Modelling Issues." Department of Statistics and Mathematics, 1999. http://epub.wu-wien.ac.at/dyn/dl/wp/epub-wu-01_a38.
Повний текст джерела"Applied State Space Modelling of Non-Gaussian Time Series using Integration-based Kalman-filtering." Department of Statistics and Mathematics, 1993. http://epub.wu-wien.ac.at/dyn/dl/wp/epub-wu-01_a20.
Повний текст джерелаEvans, LR. "Groundwaters in wet, temperate, mountainous, sulphide-mining districts : delineation of modern fluid flow and predictive modelling for mine closure (Rosebery, Tasmania)." Thesis, 2009. https://eprints.utas.edu.au/11203/8/Evans%20whole%20thesis.pdf.
Повний текст джерела