Добірка наукової літератури з теми "Modèles in cellulo et in vivo"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "Modèles in cellulo et in vivo".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Статті в журналах з теми "Modèles in cellulo et in vivo":
Sola, Brigitte, and Mélody Caillot. "L’embryon de poule." médecine/sciences 38, no. 10 (October 2022): 795–99. http://dx.doi.org/10.1051/medsci/2022123.
Völkel, Pamela, Babara Dupret, Xuefen Le Bourhis, and Pierre-Olivier Angrand. "Le modèle poisson zèbre dans la lutte contre le cancer." médecine/sciences 34, no. 4 (April 2018): 345–53. http://dx.doi.org/10.1051/medsci/20183404016.
Hosni, H., A. Salama, A. Abudunia, Y. Cherrah, A. Ibrahimi, and K. Alaoui. "Toxicité aiguë, cytotoxicité et effet antiradicalaire de l’extrait méthanolique des feuilles de l’asphodèle, Asphodelus microcarpus." Phytothérapie 18, no. 5 (July 2, 2019): 284–90. http://dx.doi.org/10.3166/phyto-2019-0136.
Gruffat, Henri, and Evelyne Manet. "Co-infection EBV/KSHV." médecine/sciences 34, no. 1 (January 2018): 79–82. http://dx.doi.org/10.1051/medsci/20183401017.
Jouault, Thierry. "Avant-propos." médecine/sciences 35, no. 2 (February 2019): 152. http://dx.doi.org/10.1051/medsci/2019011.
Begon, Emmanuelle, and Valérie Bernard. "La prolactine et son récepteur : Des modèles animaux à la physiopathologie hypophysaire." Biologie Aujourd’hui 216, no. 3-4 (2022): 105–10. http://dx.doi.org/10.1051/jbio/2022019.
TRAVEL, Angélique, Rodrigo GUABIRABA, Olivia TAVARES, Denis BELLENOT, Benjamin LEMAIRE, Hanh DUFAT, Christine FILLIAT, et al. "Méthodologies pour choisir et caractériser des extraits de plantes et évaluer leurs activités biologiques sur l’immunité des poulets." INRAE Productions Animales 35, no. 4 (March 1, 2023): 369–90. http://dx.doi.org/10.20870/productions-animales.2022.35.4.7337.
Bécot, Anaïs, Maribel Lara Corona, and Guillaume van Niel. "L’imagerie in vivo." médecine/sciences 37, no. 12 (December 2021): 1108–15. http://dx.doi.org/10.1051/medsci/2021210.
Mancheno-Ferris, Alexandra, Cédric Polesello, and François Payre. "Les facteurs OvoL." médecine/sciences 36 (October 2020): 61–66. http://dx.doi.org/10.1051/medsci/2020193.
Otterbein, C. K., H. Meyer, I. C. E. Renner Müller, and E. Munz. "Caractérisation in vitro et in vivo de deux souches de virus de la variole des dromadaires à virulence atténuée." Revue d’élevage et de médecine vétérinaire des pays tropicaux 49, no. 2 (February 1, 1996): 114–20. http://dx.doi.org/10.19182/remvt.9528.
Дисертації з теми "Modèles in cellulo et in vivo":
Teixeira, Renata Cunha. "Modèles in vitro et in vivo de leucémies aiguës humaines avec les gènes de fusion de MLL." Master's thesis, Université Laval, 2014. http://hdl.handle.net/20.500.11794/25471.
MLL fusion genes may generate three different types of acute leukemia (B-ALL, AML and T-ALL). Purified human cord blood cells by negative selection technique (Lin-CB) and having CD34+ > 70% were transduced by control retrovirus expressing the EGFP or other retrovirus expressing an MLL fusion gene and the EGFP, and then injected into the immune-deficient NSG mouse femur to test the leukemogenic potential. After 20 weeks, the mice were sacrificed and organs were analysed by FACS. MLL-ENL exclusively produced B-ALL, MLL-ELL B-ALL and AML, and MLL-AF9 B-ALL and mixed. It seems that some MLL partner genes may play an important role in phenotype, and the murine microenvironment of our in vivo model may promote the B-ALL phenotype. This study may help understand the instructive role of MLL-ENL, MLL-ELL and MLL-AF9 fusion genes in leukemic phenotype and their ability to induce the transformation of normal hematopoietic stem/progenitor cells into leukemic cells.
Toutain, Hervé. "Développement et caractérisation de modèles expérimentaux pour l'étude ex-vivo et in-vitro de la cellule tubulaire proximale de rein de lapin." Rouen, 1989. http://www.theses.fr/1989ROUES036.
Bassaglia, Yann. "Les cellules satellites musculaires dans deux modèles de myogénèse ("in vitro" et "in vivo") : différences entre un muscle lent et un muscle rapide." Paris 12, 1991. http://www.theses.fr/1991PA120031.
Passeri, Elodie. "Use of nanoliposomes rich in omega-3 for the prevention of neurodegenerative diseases : bioavailability in vivo and in cortical neurons." Electronic Thesis or Diss., Université de Lorraine, 2021. https://docnum.univ-lorraine.fr/ulprive/DDOC_T_2021_0337_PASSERI.pdf.
Alzheimer's disease (AD) is the most common cause of neurodegenerative disease and represents a major public health issue worldwide. Many therapeutic strategies have been explored for several decades, however, there is still no curative treatment and the priority remains prevention. In this thesis work, we focused on the preventive approach based on lipids, in particular omega-3 polyunsaturated fatty acids (n-3 PUFAs). N-3 PUFAs play an important role in the development, maintenance and function of the brain, and they have been the subject of particular interest in the prevention of cognitive deficits associated with neurodegenerative diseases. The objective of this work is to study the functionality and bioavailability of nanoliposomes (NL) rich in n-3 PUFAs, in order to assess their neuroprotective potential to develop new preventive strategies in aging-related diseases such as AD. To do this, a green extraction technique was used to prepare NL, from natural resources from salmon lecithin rich in n-3 PUFA. This thesis is based on three parts. The first part is devoted to a bibliographical review of new techniques to facilitate the access of molecules to the brain. NL shows a promising role, being able to improve the transport of molecules across the blood-brain barrier and reach relevant brain regions. In the second part of this work, the bioavailability of NL rich in n-3 PUFA was studied in a primary culture of cortical neuronal cells from rat embryos and in a mouse model. This study shows for the first time the brain bioavailability of NL rich in n-3 PUFA in in vitro and in vivo models. Finally, in the third part of this thesis, the physicochemical properties and transfer mechanisms of NL were studied in a primary culture of cortical neurons. These results provide new information on the interaction between NL and neurons and are promising with regards to the use of NL rich in n-3 PUFA, opening up new possibilities in the development of preventive and neuroprotective therapeutic strategies for neurodegenerative diseases such as AD
Diouani, Sara. "Implication de PiT1 dans l’apoptose induite par le TNF-α dans des modèles in vivo et in vitro". Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T036.
PiT1/SLC20A1 was identified for the first time as retroviral receptor then phosphate inorganic-dependent sodium transporter activity. Through this more a function of phosphate inorganic (Pi) transporter, PiT1 is involved in multiple cellular processes such as bone mineralization, vascular calcification, renal and intestinal reabsorption of Pi. In our laboratory, a total mice Knock Out (KO) for this gene encoding for PiT1 was generated to characterize its physiological functions. The embryonic mice PiT1 KO have a lethal phenotype through liver damage. We have previously found that additional transport-independent functions. PiT1 is involeved in proliferation and in the regulation of tumour necrosis factor (TNF)-induced apoptosis. Modulated cells was mediated by an increased activation of c-Jun N-terminal Kinase (JNK).The aim of my study was to define the role of PiT1 in apoptotic mechanisms of TNF-α signaling. For that, I have studied the regulation cascade of TNF-α pathway in Hela cells expressing shPiT1 or shScramble. My results suggest that intra-cytoplasmic loop domain of PiT1 was interact with TRAF2 ; a key element in the MAPK pathway activation. Furthermore, we also have shown that TNF-induced association of two JNK upstream kinases (Germinal Centre Kinase (GCK or MAP4K) and Mixed Lineage Kinase 3 (MLK3 or MAP3K) to PiT1 suggesting that PiT1 inducing their deactivation and thus down-regulation of JNK. Furthermore, we have shown that JNK increased signalling in PiT1-depleted cells correlates with the earlier dissociation of TRAF2 – cellular Inhibitor of Apoptosis Proteins (cIAPs) complexes. Thus, the apoptotic complex formed by caspase-8, Fas-Associated protein via Death Domain (FADD) and Receptor Interacting Protein 1 (RIP1) was more effectively activated. Moreover, PiT1 and PiT2 loops, were exchanged, thus allowing obtaining chimeric proteins BclP1-P2 and P1-BclP2. These proteins represent valuable tools to explore the mechanisms involved in the apoptotic pathway. Finally, we confirmed the relevance of these observations in vitro and showed that PiT1 gene conditional deletion in the liver of adult mice increases their sensitivity to fulminant hepatitis TNF-induced. These results are the first report of the involvement of PiT1 in a fatal pathology
Liu, Xuanli. "Rôle de la leucocidine de Panton-Valentine dans l'infection oculaire staphylococcique : étude des cibles cellulaires et des conséquences inflammatoires tissulaires rétiniennes sur des modèles d'endophtalmie in vivo et ex vivo chez le lapin." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ076/document.
Staphylococcus aureus is responsible for many infections. It secretes various virulence factors aggravating the staphylococcal infections. Panton-Valentine leucocidin (PVL) is a virulent leukotoxin from S. aureus and presents active effects towards leukocytes and neuronal cells via the C5a receptor (C5aR). The effects of PVL on retina is little known. We explored PVL retinal cell target and early retinal inflammation and tried to find the processes of bacterial toxins aggravating bacterial endophthalmitis. We employed two different rabbit models to study the PVL effects on retina: intravitreal injection in vivo and retinal explant ex vivo. In the two models, retinal ganglion cells were the only retinal neurons which express C5aR and the major cell targets of PVL in retina. PVL induced retinal Müller and microglial cell activation. The retinal explants were easily manipulated and showed obvious cellular targets of PVL and glial cell activations, they can contribute to research the effects of PVL on retina in future. PVL alone without S. aureus could induce great retinal inflammation after targeting specifically retinal neurons
Daudet, Nicolas. "Etudes in vivo et in vitro du potentiel régénératif de l'organe de Corti : recherche de facteurs moléculaires capables d'influencer ce potentiel." Montpellier 1, 2001. http://www.theses.fr/2001MON1T001.
Maltais, Chantale. "Thérapie génique ex vivo de la dystrophie musculaire de Duchenne à l'aide de cellules souches pluripotentes induites." Thesis, Université Laval, 2014. http://www.theses.ulaval.ca/2014/30769/30769.pdf.
Duchenne muscular dystrophy (DMD) is a hereditary myopathy due to the absence of dystrophin. Among the possible therapies, there is the autologous transplantation of genetically corrected myoblasts derived from human induced pluripotent stem cells (hiPSCs) of a dystrophic patient. In the first part of my research project, I have transplanted myoblasts differentiated from iPSCs of a DMD patient in the Rag/mdx mouse. These cells had been previously genetically corrected with a lentiviral vector coding for micro-dystrophin, a functional truncated version of dystrophin. The results demonstrated the expression of this micro-dystrophin in some of the hybrid fibers. However, in order to increase the graft success, the protocol of differentiation of hiPSCs in myoblasts must be improved. The second part of my project was the induction of myogenesis from hiPSCs using recombinant proteins. To accomplish this, myogenic transcription factors fused with a cell penetrating peptide were produced and purified from the bacterial system. Their capacity to enter into mesenchymal-like cells in vitro was observed and their effects on the cells are currently under study. Once optimized, these therapeutic approaches could be clinically applied to treat dystrophic patients.
Neveux, Nathalie. "Volume cellulaire et métabolisme du foie conservé : étude ex vivo sur foie de rat isolé perfusé." Paris 5, 1999. http://www.theses.fr/1999PA05P609.
Amri, Fatma. "Contribution à l’étude des mécanismes de la glioprotection anti-oxydante et anti-inflammatoire sur des modèles in vitro et in vivo de neurodégénérescences et d'ischémie cérébrale : implication potentielle des globines endogènes du système nerveux central." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4090.
Oxidative stress plays a major role in the death of neuronal cells under various neuropathological conditions. However, reactive astrocytes, by producing neuroprotective and antioxidant factors, are able to protect neurons against oxidative stress. Therefore, protecting glial cells from harmful factors is essential to prevent nerve cell damage. Brain globins, in particular, neuroglobin (Ngb) and hemoglobin (Hb), expressed in neurons and glial cells, play an important role in the metabolism of oxygen. Recently, it has been demonstrated that these proteins exert neuroprotective effects in experimental models of neurodegenerative diseases. However, no glioprotective effect has been reported. The objectives of this thesis work are to demonstrate the protective effects of Hb and Ngb in cultured astrocytes in the presence of oxidative stress and to elucidate the intracellular mechanisms involved. We have demonstrated That Hb and Ngb are able to promote the survival of astrocytes under oxidative stress conditions by significantly reducing over-production of ROS, overexpression of pro-inflammatory genes (IL-6, IL-33, iNOS) Mitochondrial dysfunction and stimulation of caspase-3/7 activity. We have also shown that anti-apoptotic effects involve the activation of ERK-MAPK signaling pathways. In addition, we verified the glioprotective effects on an animal model of chronic oxidative stress, KO mice TP53INP1, as well as on an animal model of hypoxia
Частини книг з теми "Modèles in cellulo et in vivo":
Béné, Marie Christine, Christian Drouet, Sylvain Fisson, Sylvie Fournel, and Estelle Seillès. "Modèles et tests in vivo." In Méthodes en Immunologie, 171–87. Elsevier, 2020. http://dx.doi.org/10.1016/b978-2-294-76216-1.00007-9.
Тези доповідей конференцій з теми "Modèles in cellulo et in vivo":
MAGNOL, Laetitia, Magali SAGE, Karine VUILLIER, Anne DRUILHE, and Séverine NADAUD. "L’utilisation des animaux en sciences : pourquoi et comment ?" In Les journées de l'interdisciplinarité 2022. Limoges: Université de Limoges, 2022. http://dx.doi.org/10.25965/lji.213.
Vo Quang Costantini, S., S. Petit, A. Nassif, F. Ferre, and B. Fournier. "Perspectives thérapeutiques du matrisome gingival dans la cicatrisation pathologique." In 66ème Congrès de la SFCO. Les Ulis, France: EDP Sciences, 2020. http://dx.doi.org/10.1051/sfco/20206602013.