Дисертації з теми "Model mimicry"
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Beatty, Keturi D. "Mediated chameleons: An integration of nonconscious behavioral mimicry and the parallel process model of nonverbal communication." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc9934/.
Повний текст джерелаBeatty, Keturi D. Anderson Karen Ann. "Mediated chameleons an integration of nonconscious behavioral mimicry and the parallel process model of nonverbal communication /." [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/permalink/meta-dc-9934.
Повний текст джерелаAmela, Abellan Isaac. "Bioinformatics Approaches to Protein Interaction and Complexes: Application to Pathogen-Host Epitope Mimicry and to Fe-S Cluster Biogenesis Model." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/125908.
Повний текст джерелаAntigen/antibody interactions are one of the most interesting kinds of protein interactions. The best way to prevent diseases caused by pathogens is by the use of vaccines. The advent of genomics enables genome-wide searches of new vaccine candidates, called reverse vaccinology. The most common strategy to apply reverse vaccinology is by designing subunit recombinant vaccines, which usually generate humoral immune response due to B-cell epitopes in proteins. A major problem for this strategy is the identification of protective immunogenic proteins from the surfome of the pathogen. Epitope mimicry may lead to auto-immune condition related to several human diseases. Chapter I of this thesis describes a sequence-based computational analysis that was carried out applying the BLASTP algorithm where databases containing the known linear B-cell epitopes and the surface-protein sequences of the main human respiratory bacterial pathogens were compared to the human proteome. We found that none of the 7353 linear B-cell epitopes analyzed share any sequence identity region with human proteins capable of generating antibodies, and that only 1% of the 2175 exposed proteins analyzed contain a stretch of shared sequence with the human proteome. These findings suggest the existence of a mechanism to avoid autoimmunity. We also propose a strategy for corroborating or warning about the viability of a protein linear B-cell epitope to be a putative vaccine candidate in reverse vaccinology studies. Therefore, epitopes without any sequence identity with human proteins should be good vaccine candidates, and the other way around. Protein docking is a computational method to predict the best way by which proteins interact, but, is it possible to identify what the best solution of a docking program is? The usual answer to this question is the highest score solution, but interactions between proteins are dynamic processes, and many times the interaction regions are wide enough to permit protein-protein interactions with different orientations and/or interaction energies. In some cases, as in a multimeric protein complex, several interaction regions are possible among the monomers. These dynamic processes involve interactions with surface displacements between the proteins to finally achieve the functional configuration of the protein complex. Consequently, there is not a static and single solution for the interaction between proteins, but there are several important configurations that also have to be analyzed. To extract those representative solutions from the docking output datafile, Chapter II of this thesis details the development of an unsupervised and automatic clustering application, named DockAnalyse. This application is based on the already existing DBscan clustering method, which searches for continuities among the clusters generated by the docking output data representation. The DBscan clustering method is very robust and, moreover, solves some of the inconsistency problems of the classical clustering methods like, for example, the treatment of outliers and the dependence of the previously defined number of clusters. DockAnalyse makes the interpretation of the docking solutions through graphical and visual representations easier by guiding the user to find the representative solutions. We have applied our new approach to analyze several protein interactions and model the dynamic protein interaction behavior of a protein complex. DockAnalyse might also be used to describe interaction regions between proteins and, therefore, guide future flexible dockings. The application (implemented in the R package) is accessible. The assembly of Iron-Sulfur Clusters (ISCs) in eukaryotes involves interactions between different proteins, among which is important the protein Frataxin. Deficits in this protein have been associated with iron inside the mitochondria and impaired ISC biogenesis as it is postulated to act as the iron donor for ISCs assembly in this organelle. A pronounced lack of Frataxin causes Friedreich's Ataxia, which is a human neurodegenerative and hereditary disease mainly affecting the equilibrium, coordination, muscles and heart. Moreover, it is the most common autosomal recessive ataxia. High similarities between the human and yeast molecular mechanisms that involve Frataxin have been suggested making yeast a good model to study that process. In yeast, the protein complex that forms the central assembly platform for the initial step of ISC biogenesis is composed by yeast Frataxin homolog, Nfs1-Isd11 and Isu. In general, it is commonly accepted that protein function involves interaction with other protein partners, but in this case not enough is known about the structure of the protein complex and, therefore, how it exactly functions. In Chapter III of this thesis a model of the ISC biogenesis protein complex was proposed in order to gain insight into structural details that could end up with its biological function. To achieve this goal several bioinformatics tools, modeling techniques and protein docking programs were used. As a result, the structure of the protein complex and the dynamic behavior of its components, along with that of the iron and sulfur atoms required for the ISC assembly, were modeled. This hypothesis might help to better understand the function and molecular properties of Frataxin as well as those of its ISC assembly protein partners.
Li, Xiaoshuang. "Identification and Phenotypic Plasticity of Metastatic Cells in a Mouse Model of Melanoma." FIU Digital Commons, 2017. http://digitalcommons.fiu.edu/etd/3472.
Повний текст джерелаLucca, Liliana. "Study of autoreative T cells exhibiting bi-specificity for a myelin and a neuronal antigen in a mouse model of multiple sclerosis." Toulouse 3, 2014. http://www.theses.fr/2014TOU30157.
Повний текст джерелаMultiple sclerosis (MS) is a neurological disease caused by inflammation of the central nervous system. It represents the major non-traumatic cause of disability in young adults and affects 2. 5 million people worldwide. It is believed that in MS the immune system attacks molecular components of the myelin sheath that insulates nerve fibres. My host team research is dedicated to understanding the causes and consequences of this self-destructive behaviour of the immune system. In particular, they have discovered that in a classical animal model of MS certain immune cells recognize two molecular components of the neural fibre at the same time. My research work has consisted in characterizing these cells, understanding how they are generated and demonstrating that double-recognition enables them with a greater pathogenic potential. My work on this novel mechanism of autoimmunity contributes to shed light on the pathogenic processes underlying multiple sclerosis
Schaefer, Martina Christina Marion. "The interaction between speech perception and speech production: implications for speakers with dysarthria." Thesis, University of Canterbury. Communication Disorders, 2013. http://hdl.handle.net/10092/8610.
Повний текст джерелаFung, Kwok Wing. "Models and mimics of Isopenicillin N Synthase." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335777.
Повний текст джерелаCao, Chunhua. "Exploring the Test of Covariate Moderation Effect and the Impact of Model Misspecification in Multilevel MIMIC Models." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6688.
Повний текст джерелаMeunier, Hélène. "Etudes des mécanismes sous-jacents aux phénomènes collectifs chez un primate non humain, cebus capucinus: de l'expérimentation à la modélisation." Doctoral thesis, Universite Libre de Bruxelles, 2007. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210689.
Повний текст джерелаDoctorat en sciences, Spécialisation biologie animale
info:eu-repo/semantics/nonPublished
Savle, Prashant S. "Thiazolium salts as thiamin models." Thesis, University of Cambridge, 1993. https://www.repository.cam.ac.uk/handle/1810/272636.
Повний текст джерелаFries, Torsten. "Synchronisation in der emotionalen Kommunikation Vergleich zwischen traumatisierten Patienten, Fibromyalgie-Patienten und Gesunden /." [S.l. : s.n.], 2004. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11103973.
Повний текст джерелаHegedus, Miles. "Wing shape variation in the mimetic butterfly Papilio dardanus (Papilionidae) and its unpalatable nymphalid models." ScholarWorks@UNO, 2017. https://scholarworks.uno.edu/td/2410.
Повний текст джерелаGrange, Jérémie. "Functionalization of polyisoprene : toward the mimic of natural rubber." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0004/document.
Повний текст джерелаThis PhD work focuses on a better comprehension of natural rubber (NR). Indeed, despite thefact that this material has been used for a long time in industry, some properties remainunclear. Previous works of Tanaka allowed to make a link between the biosynthesis of thematerial and its properties. It was thus suggested that NR was composed of a high molar masschain of polyisoprene (PI, > 500 000 g/mol) functionalized at the α and ω chain-end by aprotein and a phospholipidic moiety respectively. These chain-ends would be able to selfassembleinto a pseudo-physical network which would explain some of the superior propertiesof NR. The goal of this PhD work is to synthesize a Protein/PI/Lipid tri-block copolymer inorder to check this hypothesis and to synthesize hybrid material close to NR. First, a 1,4-cishetero-telechelic (ketone/aldehyde) PI of 10 000 g/mol was obtained by chemical degradationof NR, yielding a polymeric chain bearing two different functions at the chain-ends, allowingto perform a selective functionalization with both a lipidic moiety and a protein. Both di-blockcopolymers (PI/Lipid and PI/Protein) were synthesized and studied separately. The PI/Lipiddi-block copolymer revealed interesting properties. The synthesis of PI/Protein di-blockcopolymer revealed more difficult and only PI/Polypeptide di-block copolymer could havebeen obtainded. To this end, PI macro-initiator allowed the Ring-Opening Polymerization odN-carboxyanhydride. Finally, a chemical pathway was established, allowing to synthesize aPolypeptide/PI/Lipid tri-block close to Tanaka’s model
Wei, Yulei. "Genetic Knowledge-based Artificial Control over Neurogenesis in Human Cells Using Synthetic Transcription Factor Mimics." Kyoto University, 2018. http://hdl.handle.net/2433/232265.
Повний текст джерелаAlcantara, Flavio Ferraz de Paes e. "Febre reumática: um modelo animal para uma vacina humana." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-26102006-154312/.
Повний текст джерелаRheumatic fever is a good example of an autoimmune disease triggered by an infectious process. One to four weeks after the resolution of a non treated pharyngitis caused by rheumatogenic strains of S. pyogenes, the susceptible host unravels an immune response targeting joints, heart, conective tissues and brain. It is thought that molecules present in the bacteria and recognized during the infection at the pharynx are confounded with the organism self structure in a process called ?molecular mimicry?. Amongst the proteins involved in the cross reaction, it may be found cardiac myosin, on the host side, and M protein on the invading organism?s side. The latter (Mprotein) has been extensively studied. It is the basis of the S. pyogenes strains classification, and also an important virulence factor. It has also been explored as an immunogen in several vaccine strategies. The nderstanding of this disease has been hampered by the absence of an animal model that reproduces fundamental aspects of the human pathology, specially cardiac lesions. One of the reasons is the fact that animals do not get infected by S. pyogenes. Hence we have produced the recombinant M1 protein and shown that either the immunization of 28 Lewis rats for a period of 21 days or 14 rats for a period of 41 days, was capable of inducing an inflammatory response in most of the animals with variable intensity. Aschoff nodules-like or Anitschkow-like cells resembling rheumatic fever pathognomonic lesions were seen in 50% of the animals immunized subcutaneously and sacrificed on day 21. We have observed an humoral and cellular response (spleen and lymph node derived cells) specifically targeting M1 protein and the amino (M1AB) and carboxy (M1C) terminus of the protein. However, cross reactions with cardiac myosin were not observer. We have derived T lymphocyte lineages obtained from myocardium infiltrating mononuclear cells from 6 of the 10 animals immunized with M1ABC protein subcutaneously and sacrificed on day 41 and also from one out of four PBS - adjuvant immunized animals. These results suggest the presence of autoreactive cells in the myocardium of the immunized animals. In conclusion, the use of the M1 protein as an immunogen on the Lewis rat model is capable of triggering an inflammatory reaction in the myocardium and valvular tissue and it can produce rheumatic fever like lesions. The Lewis rat model is up to this moment the one to present the highest similarity with human disease. Besides, it will certainly be important on the evaluation of the protection and safety of S. pyogenes vaccines.
Andriukaitis, Rimantas. "Lietuvos šešėlinės ekonomikos faktorinis modeliavimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20090908_201759-49183.
Повний текст джерелаThere is considerable agreement internationally about the factors that determine the relative size of the underground economy and that evidence of underground activity will be captured in several economic indicators. Until recently, however, the methods that have been employed to measure the underground economy focused on only a few causal factors, one indicator, and only produced an estimate for one particular point in time. This paper presents the modeling technique that threats the underground economy as an unobservable or latent variable and incorporates multiple indicator and multiple causal variables – MIMIC model. Moreover this technique allows us to estimate the significance of each causal variable as well as each indicator. First of all the theoretical definition of the shadow economy is proposed. Further the MIMIC modeling technique is described and the emphasis is laid on the most common variables used for latter method. Subsequently, the model is defined and the corresponding economical variables of Lithuanian are chosen. Whereupon the model is estimated and respecified while nonsignificant variables and relations been removed. Finally the conclusions about the most suitable model and statistically significant variables are maid.
Vikingsson, Line Karina Alva. "An experimental model to mimic the mechanical behavior of a scaffold in a cartilage defect." Doctoral thesis, Universitat Politècnica de València, 2015. http://hdl.handle.net/10251/53912.
Повний текст джерела[ES] Resumen El objetivo principal de esta tesis doctoral es el diseño y caracterización de un modelo de cartílago articular experimental. El modelo in vitro se compone de un scaffold micro- y macroporoso de Policaprolactona con un relleno de Poli(Vinil Alcohol). El constructo scaffold/hidrogel ha sido sometido a ciclos consecutivos de congelación y descongelación con objeto de entrecruzar el hidrogel dentro de los poros del scaffold. El Poli(Vinil Alcohol) mimetiza al tejido de cartílago que se regenerará en los poros, ya que en cada ciclo de congelación y descongelación se vuelve más denso y duro. El modelo in vitro permite estudiar una gran variedad de características del scaffold e hidrogel, revelando fenómenos interesantes para la ingeniería tisular. Se ha estudiado la importancia del flujo de agua a través del scaffold en las propiedades mecánicas, así como la influencia de la microporosidad. Se ha podido constatar que la densidad del hidrogel y la microporosidad influyen de distinta forma en las propiedades mecánicas de los scaffolds porosos. Se ha estudiado la permeabilidad de los scaffolds, que ha resultado ser independiente de la densidad de entrecruzamiento del hidrogel dentro de sus poros. El modelo experimental de cartílago se ha aplicado también a un scaffold macroporoso acrílico. Los resultados muestran que el agua tiene un efecto distinto en las propiedades mecánicas de los scaffolds macroporosos y en los micro- macroporosos. El modelo de cartílago in vitro tiene valores del modulo elástico, módulo agregado y permeabilidad que son del mismo orden de magnitud que los del cartílago articular humano. El modelo permite predecir el comportamiento mecánico in vivo de scaffolds porosos. Se ha diseñado un dispositivo de implante de scaffold para experimentos en animales basado en una patente del grupo de investigación, que ha sido implantado en dos ensayos in vivo diferentes en ovejas. Los resultados muestran que la fijación y anclaje al hueso subcondral tiene un gran papel en la reparación del tejido.
[CAT] Resum L'objectiu principal d'aquesta tesi doctoral és el disseny i caracterització d'un model de cartílag articular experimental. El model in vitro es compon d'un scaffold micro- i macroporós de Policaprolactona amb un farciment de Poli(Vinil Alcohol). El constructe scaffold/hidrogel ha estat sotmès a cicles consecutius de congelació i descongelació amb l'objectiu d'entrecreuar l'hidrogel dins del porus del scaffold. El Poli(Vinil Alcohol) mimetitza al teixit de cartílag que es regenerarà en el porus, ja que en cada cicle de congelació i descongelació es torna més dens i dur. El model in vitro permet estudiar una gran varietat de característiques del scaffold i hidrogel, posant de manifest fenòmens interessants per a l'enginyeria tissular. S'ha estudiat la importància del flux d'aigua a través del scaffold en les propietats mecàniques, així com la influència de la microporositat. S'ha pogut constatar que la densitat de l'hidrogel i la microporositat influeixen de distinta manera en les propietats mecàniques dels scaffolds porosos. S'ha estudiat la permeabilitat dels scaffolds, que ha resultat ser independent de la densitat d'entrecreuament de l'hidrogel dins dels seus porus. El model experimental de cartílag s'ha aplicat també a un scaffold macroporós acrílic. Els resultats mostren que l'aigua té un efecte distint en les propietats mecàniques dels scaffolds macroporosos i en els micro- macroporosos. El model de cartílag in vitro té valors del mòdul elàstic, mòdul agregat i permeabilitat que són del mateix ordre de magnitud que els del cartílag articular humà. El model permet predir el comportament mecànic in vivo de scaffolds porosos. S'ha dissenyat un dispositiu d'implant de scaffold per a experiments en animals basat en una patent del grup d'investigació, que ha segut implantat en dos assaigs in vivo diferents en ovelles. Els resultats mostren que la fixació i ancoratge a l'os subcondral té un gran paper en la reparació del teixit.
Vikingsson, LKA. (2015). An experimental model to mimic the mechanical behavior of a scaffold in a cartilage defect [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/53912
TESIS
Genes-Hernandez, Luiza I. "Development of a microfluidic based microvascular model towards a complete blood brain barrier (BBB) mimic /." Diss., Connect to online resource - MSU authorized users, 2008.
Знайти повний текст джерелаSchwartz, Lennart. "Synthetic [FeFe] Hydrogenase Active Site Model Complexes." Doctoral thesis, Uppsala : Acta Universatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9548.
Повний текст джерелаCARRERA, ALBA. "L'integrazione cross-modale delle emozioni: componente mimica e vocale. Correlati psicofisiologici (ERPS)." Doctoral thesis, Università Cattolica del Sacro Cuore, 2007. http://hdl.handle.net/10280/154.
Повний текст джерелаThe study investigates the simultaneous processing of emotional tone of voice and emotional facial expression by event-related potentials (ERPs), through an ample range of different emotions. Auditory emotional stimuli and visual patterns were matched in congruous and incongruous pairs. ERPs variations and behavioral data (response time) were submitted to repeated measures analysis of variance (ANOVA). ANOVA showed numerous ERP effects, with different cognitive functions. Some of them, in particular the medium-latency P200, are highly sensible to pattern congruent/incongruent condition (with more intense amplitude for congruent rather then incongruent stimuli) and constitute intersensory integration specific markers. The other ERP effects, instead, are more sensible to the emotional content and signal the presence of cognitive processes that are more generally tied to the emotional decoding. Furthermore results show that, in the first processing phase, integration is an automatic and obliged phenomenon, while later it implies intentional decisional processes. Finally, a TR reduction was found for some congruous patterns (i.e. sadness) and an inverted effect for a second group of emotions (i.e. fear, anger, and surprise). Finally, behavioural results indicate that congruence causes a RT reduction for some emotions (sadness) and, on the contrary, an inverse effect for other emotions (fear, anger, surprise). This result is discussed with reference to different emotional correlates adaptive function and their respective cross-modal decoding processes.
Larkin, Adam Lyston. "The Design of Three-Dimensional Multicellular Liver Models Using Detachable, Nanoscale Polyelectrolyte Multilayers." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77190.
Повний текст джерелаPh. D.
Bilir, Mustafa Kuzey. "Mixture item response theory-Mimic model simultaneous estimation of differential item functioning for manifest groups and latent classes /." Tallahassee, Florida : Florida State University, 2009. http://etd.lib.fsu.edu/theses/available/etd-08212009-172739/.
Повний текст джерелаAdvisor: Akihito Kamata, Florida State University, College of Education, Dept. of Educational Psychology and Learning Systems. Title and description from dissertation home page (viewed on April 29, 2010). Document formatted into pages; contains xvii, 207 pages. Includes bibliographical references.
Su, Dan. "Rational design, characterization and in vivo studies of antibody mimics against HER2." Scholarly Commons, 2015. https://scholarlycommons.pacific.edu/uop_etds/133.
Повний текст джерелаStratton, Laura M. "Preparation and Characterization of [FeFe]-Hydrogenase Active Site Mimics Studied by Gas-Phase Photoelectron Spectroscopy, Electrochemistry, and Computational Models." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/311862.
Повний текст джерелаNguyen, Tan-Nhu. "Clinical decision support system for facial mimic rehabilitation." Thesis, Compiègne, 2020. http://www.theses.fr/2020COMP2590.
Повний текст джерелаFacial disorders negatively affect professional, social, and personal lives of involved patients.Thus, recovery of facial mimics into normal and symmetrical conditions allows these patients to improve their life qualities. Functional rehabilitation of facial disorders is an important clinical step to improve qualities of surgical interventions and drug therapies. However, facialmimic rehabilitation currently remains a major scientific, technological, and clinical challenge.Especially, conventional rehabilitation processes lack of quantitative and objective biofeedbacks. Moreover, rehabilitation exercises just included long-term and repetitive actions. This makes patients less ambitious for completing their training programs. Besides, numerous modeling methods, interaction devices, and system architectures have been successfully employed in clinical applications, but they have not been successfully applied for facial mimic rehabilitation. Consequently, this thesis was conducted to complement these drawbacks by designing a clinical decision-support system for facial mimic rehabilitation. Especially, patientspecific models and serious games were integrated with the system for providing quantitative and objective bio-feedbacks and training motivations. The thesis has six main contributions: (1) a novel real-time subject-specific head generation & animation systems, (2) a novel head-to-skull prediction process, (3) a muscle-oriented patientspecific facial paralysis grading system, (4) a novel serious game system for facial mimic rehabilitation, (5) a novel clinical decision-support system for facial mimic rehabilitation, and (6) a reference guide for developing real-time soft-tissues simulation systems. This thesis opens new avenues for new research areas relating to automatic generation of patient specific head from visual sensor and internal structures using statistical shape modeling and real-time modeling and simulation for facial mimic rehabilitation
Mills, Dominic Christopher. "Development of two alternative models of Campylobacter jejuni infection that more closely mimic the in vivo environment." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2011. http://researchonline.lshtm.ac.uk/1440243/.
Повний текст джерелаTye, Jesse Wayne. "Explorations of iron-iron hydrogenase active site models by experiment and theory." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1014.
Повний текст джерелаFOY, KEVIN CHU. "COMBINATION IMMUNOTHERAPY WITH HER-2/NEU AND VEGF PEPTIDE MIMICS IN BOTH TRANSGENIC AND TRANSPLANTABLE MOUSE MODELS OF HUMAN BREAST CANCER." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1299532419.
Повний текст джерелаFuges, Jennifer L. "The model of American philanthropy : as international organizations mimic our national reliance on the private sector, will they also pay a price? /." Philadelphia, Pa. : Drexel University, 2002. http://dspace.library.drexel.edu/handle/1860/393.
Повний текст джерелаHuang, Yingbo. "Intrapulmonary Inoculation of Multicellular Tumor Spheroids to Construct an Orthotopic Lung Cancer Xenograft Model that Mimics Four Clinical Stages of Non-small Cell Lung Cancer." Scholarly Commons, 2019. https://scholarlycommons.pacific.edu/uop_etds/3596.
Повний текст джерелаBühn, Andreas. "Informal Economic Activities." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-39326.
Повний текст джерелаThornton, Sabrina. "Organizational networking in business-to-business markets : construct conceptualization, operationalization and application." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/organizational-networking-in-businesstobusiness-marketsconstruct-conceptualization-operationalization-and-application(295c804a-0962-4fd2-bd45-51ad2adcb82e).html.
Повний текст джерелаJuntke, Jenny [Verfasser], and Claus-Michael [Akademischer Betreuer] Lehr. "A novel co-culture model of human bronchial epithelial cells and Pseudomonas aeruginosa biofilms to mimic chronic lung infections in cystic fibrosis / Jenny Juntke ; Betreuer: Claus-Michael Lehr." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2018. http://d-nb.info/1183673698/34.
Повний текст джерелаOtsuki, Hiroyuki. "Generation of a replication-competent simian-human immunodeficiency virus, the neutralization sensitivity of which can be enhanced in the presence of a small-molecule CD4 mimic." Kyoto University, 2014. http://hdl.handle.net/2433/188701.
Повний текст джерелаWoodcock, Cassandra. "The Design and Validation of a Computational Rigid Body Model for Study of the Radial Head." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3277.
Повний текст джерелаDunn, Noah M. "A Modified Q-Learning Approach for Predicting Mortality in Patients Diagnosed with Sepsis." Miami University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=miami1618439089761747.
Повний текст джерелаMathieu, Émilie. "Anti-oxidant Mn(II)-complexes : design and study in a cellular model of inflammatory diseases. Investigation of subcellular location." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066428.
Повний текст джерелаReactive oxygen species (ROS) are produced continuously in all aerobic organisms and are involved in cell signaling, defenses against pathogens, but also oxidative stress. This latter corresponds to an imbalance between ROS production and their consumption by the antioxidant defenses of the cell. Oxidative stress is associated with numerous pathologies, such as inflammatory bowel diseases (IBD). Among the metalloenzymes controlling the concentration of ROS, superoxide dismutases (SOD) play a crucial role. These enzymes are responsibles for the regulation of superoxide, the first ROS produced by the reduction of oxygen. In this work, Mn(II) complexes mimicking the activity of the Mn-SOD (SODm) were designed using a biomimetic approach. Their relevance to limit oxidative stress and inflammation in a cellular model of IBD was investigated. In particular, their biological activity was studied in light of their physico-chemical properties and of their bioavailability. The results obtained with a parent complex led to the design of a second generation of SOD mimics conjugated with a single core multimodal probe, cell-penetrating peptides, or mitochondria-penetrating peptides. An effect of electrostatic interactions on the catalytic rate constant of the parent complex functionalized with polyarginines peptides was demonstrated, similarly to what is observed for the enzyme. In the continuity of the biomimetic approach envisioned here, the design of de novo SOD mimics is presented and constitutes a first step toward the mimicry of second sphere influence
Stentz, Barbara. "Les représentations de la douleur dans les arts graphiques en France au XVIIIè siècle." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAG032.
Повний текст джерелаThis study aims to examine the forms and the issues of pain in graphic arts during the 18th century, as drawings and engravings take on an experimental aspect and constitute precious evidence of patterns diffusion. It considers the conventions, the debates and the codifications determining its figurative representations, in relation to aesthetic, médical, social and political matters. In a time when pain tends to be obscured by people who are supposed to be in charge of it, it seemed important to appraise its occurrences and its past depictions. Seen from this perspective, the French figurative arts through the second half of the 18th century offer a remarkable field of study. The aesthetic debates about the sculpted group of Laocoon and the veil of Timanthes, or, on a medical level, concenring pain persistence in persons convicted and decapitated, reveal that this passion was of great interest for the theorists at that time
Fenollosa, Artés Felip. "Contribució a l'estudi de la impressió 3D per a la fabricació de models per facilitar l'assaig d'operacions quirúrgiques de tumors." Doctoral thesis, Universitat Politècnica de Catalunya, 2019. http://hdl.handle.net/10803/667421.
Повний текст джерелаLa presente tesis doctoral se ha centrado en el reto de conseguir, mediante Fabricación Aditiva (FA), modelos para ensayo quirúrgico, bajo la premisa que los equipos para obtenerlos tendrían que ser accesibles al ámbito hospitalario. El objetivo es facilitar la extensión del uso de modelos como herramienta de preparación de operaciones quirúrgicas, transformando la práctica médica actual de la misma manera que, en su momento, lo hicieron tecnologías como las que facilitaron el uso de radiografías. El motivo de utilizar FA, en lugar de tecnologías más tradicionales, es su capacidad de materializar de forma directa los datos digitales obtenidos de la anatomía del paciente mediante sistemas de escaneado tridimensional, haciendo posible la obtención de modelos personalizados. Los resultados se centran en la generación de nuevo conocimiento para conseguir equipamientos de impresión 3D multimateriales accesibles que permitan la obtención de modelos miméticos respecto a los tejidos vivos. Para facilitar la buscada extensión de la tecnología, se ha focalizado en las tecnologías de código abierto como la Fabricación por Hilo Fundido (FFF) y similares basadas en líquidos catalizables. Esta investigación se alinea dentro de la actividad de desarrollo de la FA en el CIM UPC, y en este ámbito concreto con la colaboración con el Hospital Sant Joan de Déu de Barcelona (HSJD). El primer bloque de la tesis incluye la descripción del estado del arte, detallando las tecnologías existentes y su aplicación al entorno médico. Se han establecido por primera vez unas bases de caracterización de los tejidos vivos – principalmente blandos – para dar apoyo a la selección de materiales que los puedan mimetizar en un proceso de FA, a efectos de mejorar la experiencia de ensayo de los cirujanos. El carácter rígido de los materiales mayoritariamente usados en impresión 3D los hace poco útiles para simular tumores y otras referencias anatómicas. De forma sucesiva, se tratan parámetros como la densidad, la viscoelasticidad, la caracterización de materiales blandos en la industria, el estudio del módulo elástico de tejidos blandos y vasos, la dureza de los mismos, y requerimientos como la esterilización de los modelos. El segundo bloque empieza explorando la impresión 3D mediante FFF. Se clasifican las variantes del proceso desde el punto de vista de la multimaterialidad, esencial para hacer modelos de ensayo quirúrgico, diferenciando entre soluciones multiboquilla y de mezcla en el cabezal. Se ha incluido el estudio de materiales (filamentos y líquidos) que serían más útiles para mimetizar tejidos blandos. Se constata como en los líquidos, en comparación con los filamentos, la complejidad del trabajo en procesos de FA es más elevada, y se determinan formas de imprimir materiales muy blandos. Para acabar, se exponen seis casos reales de colaboración con el HJSD, una selección de aquellos en los que el doctorando ha intervenido en los últimos años. El origen se encuentra en la dificultad del abordaje de operaciones de resección de tumores infantiles como el neuroblastoma, y en la iniciativa del Dr. Lucas Krauel. Finalmente, el Bloque 3 desarrolla numerosos conceptos (hasta 8), actividad completada a lo largo de los últimos cinco años con el apoyo de los medios del CIM UPC y de la actividad asociada a trabajos finales de estudios de estudiantes de la UPC, llegándose a materializar equipamientos experimentales para validarlos. La investigación amplia y sistemática al respecto hace que se esté más cerca de disponer de una solución de impresión 3D multimaterial de sobremesa. Se determina que la mejor vía de progreso es la de disponer de una pluralidad de cabezales independientes, a fin de capacitar la impresora 3D para integrar diversos conceptos estudiados, materializándose una posible solución. Para cerrar la tesis, se plantea cómo sería un equipamiento de impresión 3D para modelos de ensayo quirúrgico, a fin de servir de base para futuros desarrollos.
Gaspard, Jeffery Simon. "Using Self-Assembled Block Copolymer Macrostructures for Creating a Model System for Cell Mimicry." 2009. http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7346.
Повний текст джерела"Applying bio-mimicry to design an eco-efficient supply chain model for the South African Post Office." Thesis, 2015. http://hdl.handle.net/10210/13573.
Повний текст джерелаLibnarová, Helena. "Strašilky jako modelová skupina ve výuce přírodopisu." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-327309.
Повний текст джерелаŠulc, Michal. "Zrakové podněty v koevoluci hnízdního parazita a jeho hostitelů." Doctoral thesis, 2016. http://www.nusl.cz/ntk/nusl-353584.
Повний текст джерелаMcArthur, Lachlann Bradley. "Explanatory statistical modelling of influences of demographic experience on political identity." Thesis, 2019. http://hdl.handle.net/2440/121918.
Повний текст джерелаThesis (MPhil) -- University of Adelaide, School of Mathematical Sciences, 2019
DOBROVODSKÝ, Juraj. "Závislost mimetické podobnosti myrmekomorfních pavouků na nechutnosti modelu." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-371669.
Повний текст джерелаKunte, Krushnamegh Jagannath 1973. "Evolution of sex-limited mimicry in swallowtail butterflies." 2008. http://hdl.handle.net/2152/18078.
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Natvik, Mathis. "Ecosystems as Models for Plant Selection on Extensive Green Roofs in Southern Ontario." Thesis, 2009. http://hdl.handle.net/10214/3615.
Повний текст джерелаSoares, Cláudia Godinho. "a economia não registada em portugal: Modelo monetário e do modelo Mimic." Master's thesis, 2014. https://repositorio-aberto.up.pt/handle/10216/77838.
Повний текст джерелаSoares, Cláudia Godinho. "a economia não registada em portugal: Modelo monetário e do modelo Mimic." Dissertação, 2014. https://repositorio-aberto.up.pt/handle/10216/77838.
Повний текст джерелаHeverly-Coulson, Gavin. "COMPUTATIONAL MODEL OF THE CATALYTIC CYCLE OF ORGANOSELENIUM ANTIOXIDANTS." 2012. http://hdl.handle.net/10222/15141.
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