Добірка наукової літератури з теми "MiRNA-screening"
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Статті в журналах з теми "MiRNA-screening"
Ying, Huanchun, Jing Lyu, Tianshu Ying, Jun Li, Shanshan Jin, Jingru Shao, Lili Wang, and Hongying Xu. "Risk miRNA screening of ovarian cancer based on miRNA functional synergistic network." Journal of Ovarian Research 7, no. 1 (2014): 9. http://dx.doi.org/10.1186/1757-2215-7-9.
Повний текст джерелаNielsen, Søren Jensby, Hanni Willenbrock, Jacob Fog, Jan Stenvang, Thorarinn Blondal, Torben Orntoft, Nils Brünner, Claus Lindbjerg Andersen, Hans J. Nielsen, and Adam Baker. "Validation of a plasma-based miRNA PCR test for early detection of colorectal cancer." Journal of Clinical Oncology 30, no. 4_suppl (February 1, 2012): 424. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.424.
Повний текст джерелаEulalio, Ana, and Miguel Mano. "MicroRNA Screening and the Quest for Biologically Relevant Targets." Journal of Biomolecular Screening 20, no. 8 (March 30, 2015): 1003–17. http://dx.doi.org/10.1177/1087057115578837.
Повний текст джерелаRoa, W., L. J. Xing, J. Amanie, A. Fairchild, Z. Gabos, T. Nijjar, R. Scrimger, and D. Yee. "14 SCREENING LUNG CANCER WITH MIRNA EXPRESSION PROFILES." Radiotherapy and Oncology 92 (September 2009): S5. http://dx.doi.org/10.1016/s0167-8140(12)72401-5.
Повний текст джерелаOka, Hiroyuki, Koichi Masuno, Takeki Uehara, Toru Okamoto, Yoshiharu Matsuura, Toru Nakano, and Shinpei Yamaguchi. "Novel miRNA biomarkers for genotoxicity screening in mouse." Toxicology 404-405 (July 2018): 68–75. http://dx.doi.org/10.1016/j.tox.2018.05.009.
Повний текст джерелаSiebert, Marina, Wendy Westbroek, Yu-Chi Chen, Nima Moaven, Yan Li, Maria Luiza Saraiva-Pereira, Scott Martin, and Ellen Sidransky. "MiRNAs and glucocerebrosidase: lessons from miRNA mimic screening." Molecular Genetics and Metabolism 111, no. 2 (February 2014): S98. http://dx.doi.org/10.1016/j.ymgme.2013.12.239.
Повний текст джерелаZanutto, Susanna, Chiara Maura Ciniselli, Antonino Belfiore, Mara Lecchi, Enzo Masci, Gabriele Delconte, Massimo Primignani, et al. "Plasma miRNA‐based signatures in CRC screening programs." International Journal of Cancer 146, no. 4 (August 5, 2019): 1164–73. http://dx.doi.org/10.1002/ijc.32573.
Повний текст джерелаLorenz, Daniel A., Steve Vander Roest, Martha J. Larsen, and Amanda L. Garner. "Development and Implementation of an HTS-Compatible Assay for the Discovery of Selective Small-Molecule Ligands for Pre-microRNAs." SLAS DISCOVERY: Advancing the Science of Drug Discovery 23, no. 1 (July 7, 2017): 47–54. http://dx.doi.org/10.1177/2472555217717944.
Повний текст джерелаMellis, David, and Andrea Caporali. "MicroRNA-based therapeutics in cardiovascular disease: screening and delivery to the target." Biochemical Society Transactions 46, no. 1 (December 1, 2017): 11–21. http://dx.doi.org/10.1042/bst20170037.
Повний текст джерелаPfaff, Nils, Jan Fiedler, Angelika Holzmann, Axel Schambach, Thomas Moritz, Tobias Cantz, and Thomas Thum. "miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2." EMBO reports 12, no. 11 (September 23, 2011): 1153–59. http://dx.doi.org/10.1038/embor.2011.176.
Повний текст джерелаДисертації з теми "MiRNA-screening"
Bhajun, Ricky. "Une approche réseau pour l’inférence du rôle des microARN dans la corégulation des processus biologiques." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAS045/document.
Повний текст джерелаRNA interference is a process in which a small non-coding RNA will bind to a specific messenger RNA and regulate its expression. This evolutionary conserved mechanism is found in all superior eukaryotes from plants to mammals. Nowadays, we know that RNA interference is a major regulatory process involved in developmental biology and tumor progression. MicroRNAs (miRNAs) are endogenous (coded in and produced by the cell) non-coding RNAs which are able to regulate a whole set of genes, typically hundreds of genes. This doctoral thesis consisted in the analysis of the miRNA mediated coregulation through a network approach based on target sharing. Coregulation is the process where many different miRNAs will regulate the same set of genes and thus the same biological process. In particular, the work consisted in the inference of a miRNA network, in its topological analysis and also its biological interpretation. Indeed, the final aim of the work was to generate new biological hypothesis. As such, two different groups of miRNAs were first retrieved. One of them was predicted to be involved in the small GTPase signaling and was further validated in vitro. Moreover, a miRNA community involved in the maintenance of stem cells pluripotency was also discovered. Finally, a systemic analysis of the target-based miRNAs network was conducted to better understand their integration with biologic networks and their role in cell fate
Naidoo, Jerolen. "Functional miRNA-based Phenotypic Screening as a tool to delineate HIV-host interactions and facilitate Novel Drug Discovery." Thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/33227.
Повний текст джерелаVillegas, Mirón Pablo 1991. "A Comprehensive screening of X-linked and miRNA-driven signatures of positive selection and the role of cis-regulatory elements in the human genome." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/672657.
Повний текст джерелаLa historia evolutiva del genoma humano ha sido configurada por la selección de numerosos elementos en respuesta a distintas presiones evolutivas. El análisis de adaptaciones regulatorias y de las particularidades de los cromosomas sexuales son clave para entender las distintas consecuencias de algunos de estos procesos. En esta tesis describimos cómo procesos de selección reciente han configurado el cromosoma X en distintas poblaciones humanas, centrándonos en varios candidatos bajo selección, sus propiedades hereditarias y el papel de elementos regulatorios. También describimos la relevancia de enhancers humanos en los programas regulatorios de tejidos específicos. La expresión de genes implicados en las funciones específicas de tejido aparece principalmente regulada por enhancers ubicados en intrones, por otro lado, genes implicados en el mantenimiento básico de la célula están predominantemente controlados por enhancers intergénicos. También analizamos el papel evolutivo de microRNAs humanos, con especial énfasis en patrones de diversidad globales y su implicación en prevalencias poblaciones de algunas de las enfermedades humanas más comunes.
Mirihana, Arachchilage Gayan S. "REGULATORY ROLES OF G-QUADRUPLEX IN microRNA PROCESSING AND mRNA TRANSLATION." Kent State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=kent1469576783.
Повний текст джерелаDojahn, Claudine. "Synthese und Screening von Inhibitoren der mikroRNA-Reifung." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16748.
Повний текст джерелаThe objective of this work was the synthesis of small molecules, which bind to pre-miRNAs to prevent their maturation to fully active miRNAs. To create a substance library of bivalent inhibitors, the RNA binding motifs 2-deoxystreptamine as well as neamine were alkyne modified and linked with several bisazides via a copper catalyzed alkyne-azide cycloaddition (CuAAC). Hence, optimized syntheses of the basic building blocks along with an effective and reliable CuAAC-protocol were established. 88 test substances were isolated in good yield and high purity. Finally they were analyzed with regard to their potential to selectively inhibit the miRNA maturation. For this purpose, the assay was performed under competitive conditions with a set of two pre-miRNA-pairs. The initial screening revealed several inhibitors with IC50-values in the lower µM range. The second focus of this work was on the development of a synthetic access to alkyne modified ribonucleotides to establish a chemo-enzymatic functionalization strategy for RNAs using in-vitro-transcription, ligation and CuAAC. In this context, the syntheses of 3‘,5‘-O,O-bisphosphate-5-ethinyl uridine and O-(5‘-guanosine)-O-propargyl monophos-phate are described for the first time. The guanosine monophosphate was used as transcription starter to address the 5’-end of RNA and was consecutively labeled with an azido-tagged quencher. The uridine bisphosphate was conjugated with a fluorophor and introduced to the 3’-end of RNAs by T4 RNA ligase 1. Moreover, the uridine bisphosphate can be ligated to the 3’-end without a fluorophor attached, to serve as a connecting point for a further ligation with an oligonucleotide of any length. Thereby, the former terminal alkynylated uridine was shifted to a defined internal position by successive enzymatic reactions and was successfully derivatized with a fluorophor by CuAAC.
Частини книг з теми "MiRNA-screening"
Han, Bo. "Screening miRNA for Functional Significance by 3D Cell Culture System." In MicroRNA Protocols, 193–201. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7601-0_16.
Повний текст джерелаArmstrong, Richard N., Hilary A. A. Colyer, and Ken I. Mills. "Screening for miRNA Expression Changes Using Quantitative PCR (Q-PCR)." In Methods in Molecular Biology, 293–302. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-612-8_18.
Повний текст джерелаArmstrong, Richard N., Hilary A. A. Colyer, and Ken I. Mills. "Screening for miRNA Expression Changes Using Quantitative PCR (Q-PCR)." In Methods in Molecular Biology, E1. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-612-8_29.
Повний текст джерелаGuijarro, Maria V., and Amancio Carnero. "Genome-Wide miRNA Screening for Genes Bypassing Oncogene-Induced Senescence." In Methods in Molecular Biology, 53–68. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6670-7_5.
Повний текст джерелаLi, Yan, Bing Chen, and Shenglin Huang. "Identification of circRNAs for miRNA Targets by Argonaute2 RNA Immunoprecipitation and Luciferase Screening Assays." In Methods in Molecular Biology, 209–18. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7562-4_17.
Повний текст джерелаHaga, Christopher L., Sai Pradeep Velagapudi, Jessica L. Childs-Disney, Jacqueline Strivelli, Matthew D. Disney, and Donald G. Phinney. "Rapid Generation of miRNA Inhibitor Leads by Bioinformatics and Efficient High-Throughput Screening Methods." In Methods in Molecular Biology, 179–98. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6563-2_13.
Повний текст джерелаPeriwal, Vinita, and Vinod Scaria. "Machine Learning Approaches Toward Building Predictive Models for Small Molecule Modulators of miRNA and Its Utility in Virtual Screening of Molecular Databases." In Methods in Molecular Biology, 155–68. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6563-2_11.
Повний текст джерела"In Silico Screening of miRNA Target Sites." In Encyclopedia of Systems Biology, 1015. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_100674.
Повний текст джерелаPower, Michael L., Caroline W. Quaglieri, Eda G. Reed, and Jay Schulkin. "The Functions of MicroRNA in Female Reproduction." In Integrating Evolutionary Biology into Medical Education, 132–47. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198814153.003.0008.
Повний текст джерелаJayasinghe, Ravindri, Umesh Jayarajah, and Sanjeewa Seneviratne. "Circulating Biomarkers in Predicting Pathological Response to Neoadjuvant Therapy for Colorectal Cancer." In Biomarkers in Medicine, 113–32. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815040463122010008.
Повний текст джерелаТези доповідей конференцій з теми "MiRNA-screening"
Koga, Yoshikatsu, Nobuyoshi Yamazaki, Yasuo Kakugawa, Takahisa Matsuda, Masaaki Ito, Yutaka Saito, Hiroshi Saito, and Yasuhiro Matsumura. "Abstract 5292: Multitarget fecal miRNA test combined with fecal occult blood test and fecal miRNA test for colorectal cancer screening." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-5292.
Повний текст джерелаKoga, Yoshikatsu, Masahiro Yasunaga, and Yasuhiro Matsumura. "Abstract 4448: Fecal miRNA test using microRNA expressions of exfoliated colonocytes for colorectalcancer screening." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4448.
Повний текст джерелаHeneghan, HM, N. Miller, N. Healy, J. Newell, and MJ Kerin. "Abstract P3-10-02: Circulating miRNA Signature: Potential Screening and Prognostic Tool for Breast Cancer." In Abstracts: Thirty-Third Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 8‐12, 2010; San Antonio, TX. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/0008-5472.sabcs10-p3-10-02.
Повний текст джерелаMichailidi, Christina, Tal Hadar, Kaitlyn Zenner, Mark Schoenberg, George Netto, David Sidransky, and Mohammad O. Hoque. "Abstract 4193: Exposure to arsenic and miRNA deregulation: a potential non-invasive screening tool for urothelial cell carcinoma." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-4193.
Повний текст джерелаNaccarati, Alessio, Daniela De Maria, Francesca Cordero, Barbara Pardini, Stavrula Gouzounis, Maddalena Arigoni, Raffaella Rizzolo, et al. "Abstract LB-366: miRNA as markers of CIN risk and persistence for optimization of HPV-based cervical cancer screening." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-lb-366.
Повний текст джерелаDeng, Jianzhi, Yuehan Zhou, Xiaohui Cheng, and Mingjun Xu. "Screening and Analysis of lncRNA Biomarkers and the Relationship with the Corresponding Regulatory miRNA for Progressive Acute Lymphoblastic Leukemia." In Proceedings of the 2019 International Conference on Modeling, Simulation and Big Data Analysis (MSBDA 2019). Paris, France: Atlantis Press, 2019. http://dx.doi.org/10.2991/msbda-19.2019.51.
Повний текст джерелаBoeri, Mattia, Carla Verri, Cristina Borzi, Todd Holscher, Matteo Dugo, Andrea Devecchi, Elisa Romeo, et al. "Abstract 2753: Mutational profiles from targeted NGS combine with miRNA-based liquid biopsy to predict survival in LDCT screening-detected lung cancers." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-2753.
Повний текст джерелаDriscoll, James J., and Sajjeev Jagannathan. "Abstract 1462: Tandem genome-wide and functional screening reveals that MiRNA-29 regulates the proteasome activator PSME4 to promote therapeutic resistance in myeloma." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-1462.
Повний текст джерелаÖstling, Päivi, Suvi-Katri Leivonen, Pekka Kohonen, Anna Aakula, Petteri Hintsanen, Tero Aittokallio, Merja Perälä, and Olli Kallioniemi. "Abstract 5273: Systematic functional screening, miRNA and target expression analyses reveal miR-19, -124, -583, -129 and -876 as key nodes in prostate cancer proliferation networks." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5273.
Повний текст джерелаЗвіти організацій з теми "MiRNA-screening"
Whitham, Steven A., Amit Gal-On, and Victor Gaba. Post-transcriptional Regulation of Host Genes Involved with Symptom Expression in Potyviral Infections. United States Department of Agriculture, June 2012. http://dx.doi.org/10.32747/2012.7593391.bard.
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