Дисертації з теми "Microneedle Array"
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Garland, M. J. "Optimisation of microneedle array design for microneedle mediated ionophoretic transdermal drug delivery." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557417.
Повний текст джерелаZhao, Tianxin Zhao. "Silk Based Porous Microneedle Array for Programmable Drug Delivery." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1468852925.
Повний текст джерелаChoi, Seong-O. "An Electrically Active Microneedle Electroporation Array for Intracellular Delivery of Biomolecules." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/19710.
Повний текст джерелаGuvanasen, Gareth Sacha. "Stretchable microneedle electrode array for stimulating and measuring intramuscular electromyographic activity." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54392.
Повний текст джерелаHeld, Jochen. "Microneedle electrode arrays for cellular recording applications." Tönning Lübeck Marburg Der Andere Verl, 2009. http://d-nb.info/1001047702/04.
Повний текст джерелаThakur, R. R. S. "Swellable Hydogel Microneedle Arrays for Transdermal Drug Delivery." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527897.
Повний текст джерелаCoulman, Sion Andrew. "Gene delivery to human skin using microneedle arrays." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/54257/.
Повний текст джерелаHamilton, Jordan David. "Fabrication and analysis of injection molded plastic microneedle arrays." Thesis, Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/39481.
Повний текст джерелаEltayib, Eyman Mohamed. "Hydrogel-forming microneedle arrays for minimally-invasive therapeutic monitoring." Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.705914.
Повний текст джерелаJustin, Richard. "Chitosan-graphene nanocomposite microneedle arrays for transdermal drug delivery." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/9544/.
Повний текст джерелаMantha, Satya Nymisha. "Fabrication of PPF Based Drug Containing Microneedle Arrays by Microstereolithography." University of Akron / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1374434592.
Повний текст джерелаAlzahrani, Sharifah Yahya. "Dissolving microneedle arrays for enhanced transcutaneous delivery of a model antigen." Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.602410.
Повний текст джерелаFung, Peter W. (Peter Waitak). "Evaluation of polyelectrolyte multilayer thin-film coated microneedle arrays for transcutaneous vaccine delivery." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/69787.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references (p. 43-46).
The skin is an ideal organ for the safe and convenient delivery of vaccines, small molecules, and other biologics. Members of the Irvine and Hammond groups have developed a polyelectrolyte multilayer thin film-coated microneedle platform that can achieve simultaneous DNA and nanoparticle delivery. This delivery platform has the advantage of direct delivery of DNA or polymer nanoparticles to immune-active cells at the interface between the dermis and epidermis, enhancing uptake of the delivered cargo by resident immune cells. Ideal for the delivery of DNA vaccines, this platform aims to bridge the gap in the lack of efficient delivery platforms hampering the effectiveness of DNA vaccines. The ability to co-deliver polymer nanoparticles can serve as a conduit for delivering immune stimulating adjuvants or other drugs for therapeutic applications. An overview of current vaccine and delivery system research is presented. Market factors for the commercialization of the polyelectrolyte multilayer thin film-coated microneedle delivery platform are considered along with the risk factors in bringing this invention to market. An assessment of the intellectual property surrounding the platform is performed and a preliminary market entry strategy is developed for minimizing the risks commercialization.
by Peter W. Fung.
M.Eng.
Choi, Yoonsu. "A Three-Dimensional Coupled Microelectrode and Microfluidic Array for Neuronal Interfacing." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/11638.
Повний текст джерелаWang, Po-Chun. "Fabrication, packaging, and application of micromachined hollow polymer needle arrays." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/50283.
Повний текст джерелаPearton, Marc. "Delivery of pDNA to human skin facilitated by microneedle arrays : potential for DNA vaccination." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/55676/.
Повний текст джерелаKorkmaz, Emrullah. "Biodissolvable Microneedle Arrays for Effective Transdermal and Intradermal Delivery of Vaccines and Therapeutics: Manufacturing and Cutaneous Applications." Research Showcase @ CMU, 2016. http://repository.cmu.edu/dissertations/761.
Повний текст джерелаLu, Yanfeng. "A Study on Liquid Bridge Based Microstereolithography (LBMSL) System." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1468252608.
Повний текст джерелаGülçür, Mert, J.-M. Romano, P. Penchev, Timothy D. Gough, Elaine C. Brown, S. Dimov, and Benjamin R. Whiteside. "A cost-effective process chain for thermoplastic microneedle manufacture combining laser micro-machining and micro-injection moulding." Elsevier, 2021. http://hdl.handle.net/10454/18446.
Повний текст джерелаHigh-throughput manufacturing of transdermal microneedle arrays poses a significant challenge due to the high precision and number of features that need to be produced and the requirement of multi-step processing methods for achieving challenging micro-features. To address this challenge, we report a flexible and cost-effective process chain for transdermal microneedle array manufacture that includes mould production using laser machining and replication of thermoplastic microneedles via micro-injection moulding (micromoulding). The process chain also incorporates an in-line manufacturing data monitoring capability where the variability in the quality of microneedle arrays can be determined in a production run using captured data. Optical imaging and machine vision technologies are also implemented to create a quality inspection system that allows rapid evaluation of key quality indicators. The work presents the capability of laser machining as a cost-effective method for making microneedle moulds and micro-injection moulding of thermoplastic microneedle arrays as a highly-suitable manufacturing technique for large-scale production with low marginal cost.
This research work was undertaken in the context of MICRO-MAN project (“Process Fingerprint for Zero-defect Net-shapeMICROMANufacturing”, http://www.microman.mek.dtu.dk/).MICROMAN is a European Training Network supported byHorizon 2020, the EU Framework Programme for Research andInnovation (Project ID: 674801). This research has also receivedfunding and support from two other Horizon 2020 projects:HIMALAIA (Grant agreement No. 766871) and Laser4Fun (GA no.675063).
The full-text of this article will be released for public view at the end of the publisher embargo on 04 Feb 2022.
Hu, Hung-Chieh, and 胡宏杰. "Fabrication of CMC Microneedle Array." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/mv9zxj.
Повний текст джерела國立臺北科技大學
有機高分子研究所
100
Micro Electro Mechanical System fabrication technology(MEMS) has been used to be miniaturization of the microneedle array. The microneedle array can penetrate the stratum corneum of the skin without stimulation to the deep tissue of nerve. The literatures have reported that biodegradable and water-soluble polymer microneedle arrays can be completely dissolved in the skin, and non-toxic. Therefore, users do not have to worry about permanent residual from fracture of microneedle, and unsafety of reuse. There is also not any medical waste generated by using microneedle. In this study, we present the frabrication microneedles of water-soluble polymer, Carboxymethylcellulose(CMC), which is approved to be biocompatible by the Food and Drug Agency(FDA)of the United States. We used micro-electromechanical system and micromold technique to fabricate CMC microneedles. First, microneedle master structure was created using etching technique with controlled process parameters to produce cylindrical array on silicon wafer. SU-8 was then coated on the mold to create the SU-8 master structure of depth 250um. The SU-8 master structure was then coated with polydimethylsiloxane(PDMS)to make PDMS molds for replication. Finally, the PDMS molds were covered with CMC solution. The CMC microneedle can be removed from the PDMS mold after thermal curing.
Yang, Yi-Cheng, and 楊益成. "Topography Optimization and Manufacture of Soluble Microneedle Array." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/95s8a3.
Повний текст джерела明志科技大學
機械工程系機械與機電工程碩士班
103
The present study aimed to design a drug-delivery microneedle that could facili-tate painless drug administration using soluble materials exhibiting specific shapes and robustness. To achieve these specifications, ANSYS software was employed to ana-lyze the mechanical strength and lateral deflection critical load of the designs (pyra-mid column, triangular column, pentagon column and cone cloumn). The structural design was examined using the Taguchi method combined with critical buckling anal-ysis to identify the optimal size for the microneedle array. Mechanical strength analysis showed that when applying the same pressure, the stress among each shape of the tip was near 70 MPa error of ± 0.5 MPa, it can not dis-tinguish the difference, buckling analysis showed that the buckling load of pyramid column is 0.117 N, triangular column is 0.091 N, pentagon column was 0.087 N and cone column is 0.068 N, The analysis results indicated that pyramidal column exhib-ited superior cirtical load strength. An inclined exposure technique and micro molding method were used to fabri-cate the microneedle array. Carboxymethyl cellulose was selected as the constituents of the microneedle array. For the manufacturing process, the inclined exposure tech-nique was first employed in a laboratory to produce a pyramidal column-shaped sam-ple (base length = 320 μm, microneedle height = 650 μm, needle tip width = 15 μm) and an equilateral triangular column-shaped sample (base length = 396 μm, micronee-dle height = 650 μm, needle tip width = 15 μm). Then, high precision micro molding was employed using polydimethylsiloxane material to fabricate the female mold. Lastly, centrifugal casting was used to produce the microneedle structures. Microneedles degradation test consists of in vitro and in vivo tests, in vitro tests using Hank solution asbhuman body solution, microneedle are completely degraded within a minute,in vivo test inserts microneedles into rabbit and observe the degradation, the result was showed that it’s completely degraded in twenty-five minutes. In needle buckling load tests when pyra-mid column is forced 0.307 N which produce buckling; triangular column is forced 0.1257 N which produce buckling. Through this study confirmed that the pyramid shape needles have the better design of critical load and achieve the purpose of miceoneedles imme-diately degradation after piercing the skin.
Chung, Yueh-Ching, and 鍾岳錦. "Research on Fabrication and Strength of Microneedle Array." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/35848412876030598259.
Повний текст джерела國立臺灣大學
機械工程學研究所
93
How to fabricate microneedle array is the purpose of the research,. There are two kinds of microneedle array that we can find, one is in-plan microneedle arrays and another is out-of-plan microneedle arrays. In the early almost people focus on in-plan microneedle. Because we need smaller chips and to improve probability of getting blood, now people pay more attention on the application and research of out-of plan microneedle arrays. Using dry etching to fabricate out-of-plan micronedle arryas is the purpose of this research. Using this way can save time and escape unnecessary dangerous. In general people use wet etching to fabricate microneedle arrays. Isotropic etching liquid is HNA which include HF. HF is the most dangerous sour in chemical. Almost material can’t resist HF. So if we use HNA to fabricated microneedle array, we should be more carefully. In order to improve this problem, we use inductively couple plasma (ICP) to complete isotropic etching in this research. And we can try to collocate anisotropic etching to fabricated microneedle arrays that save more space and more height. After fabricating, we should measure the strength of microneedle arrays. This will be helpful to Integrate bio-chip.
Li, Chun-Hsien, and 黎俊賢. "The Application of polymethylmethacrylate Microneedle Array for Cells Delivery." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/78806304976883338656.
Повний текст джерела國立臺灣大學
醫學工程學研究所
104
Cell therapy is a kind of treatment method that delivers cells which are cultured in vitro into the human body in order to recover missing or damaged cells. In the past, cells are delivered by injection, but this way may make patients painful, have the possibility for patients to get infected, need trained personnel to operate and have the possibility of forming hematoma or bleeding. In this study, we used microneedle array as a carrier for cells delivering. With its small size, the subcutaneous wound is smaller and it will not touch nerves under the skin, so improvement of patients’ comfort can be easily achieved. Besides, using microneedle array will not require trained personnel to assist operating. Finally, it will reduce the risk of infection and hematoma formation. We used polymethyl-methacrylate (PMMA) as the material for fabricating microneedle array due to its adequate mechanical strength, excellent biocompatibility, stability and lower price. We are looking forward to using microneedle array made of PMMA to act as a carrier for cells delivering in order to treat missing or damaged cells in the human body. In this study, we used polydimethylsiloxane(PDMS) mold for fabricating PMMA microneedle array. Biocompatibility and cell viability were evaluated by MTT assay. Cell adhesion and proliferation on microneedle array were examined by Live/Dead Staining and SEM. Moreover, we used collagen, alginate and acellular skin as a delivered material to observe whether the cells can deliver from microneedle array to another place. The results show that PMMA microneedle array has good biocompatibility and cells can attach and grow on it. Besides, cells on the microneedle array can successfully deliver to collagen, alginate and acellular skin. Therefore, microneedle array with cell therapy is a new and highly potential treatment method.
Fong, Zeng-Bing, and 曾秉豐. "The Study on Design and Fabrication for Hollow Microneedle Array." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/06425464664181746460.
Повний текст джерела國立臺灣科技大學
機械工程系
104
In order to not easily make patients feel pain during insertion. There are many researchs have explored the geometric design and fabrication of microneedle array, but fewer explore inserting destruct. In the dynamically penetrating simulation, the basic geometry of the octagon, hexagon, taper , and pyramid could be obtained by using finite element software ANSYS in this study. The results showed that pyramidal microneedle array are the best design of penetrating.The hollow microneedle array is fabricated successfully by contacting exposure with three-dimensional mask. It is found that the geometry of the fabricated microneedle array are affected by square metal aperture stop and the altitude of photoresist. When the photoresist coating thickness is higher, the bottom corner will be more close to predict.
Ming-TaLee and 李明達. "Fabrication of Microneedle Array: Inductively Coupled Plasma Etching and Spin Coating." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/54030595026255628554.
Повний текст джерела國立成功大學
化學工程學系碩博士班
100
In this study, we have investigated fabrication of silicon microneedles which were then used to generate polydimethyl siloxane (PDMS) negative relief for subsequent usage of making polymeric microneedles via casting and spin coating. The silicon microneedles with different geometric shapes and sizes were fabricated by inductively coupled plasma- reactive ion etching (ICP-RIE) process. It is found that the conical shaped microneedles with aspect ratio around 0.5 were obtained by one step direct etching. When applying the proposed two-step approach, i.e. making micropillars, followed by lateral etching, the spear-like or nail-like microneedles with aspect ratio between 5-10 were obtained. The polymeric microneedles can be produced by both casting and spin coating processes. Spin coating provides a better alternative in terms of shorter processing time and better control of film thickness. For the spin coating process, it is found that the spin-rate dependent film thickness is highly associated with the rheological property of the polymer solution. By using the proper rheological model, the relationship between the film thickness and spin rate can be estimated, which is in a relatively good agreement with the experimental results.
Yang, Chieh-Cheng, and 楊傑丞. "Process Parameter Study of Dip-drawing Technology for Making Microneedle Array." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/69ktww.
Повний текст джерела國立彰化師範大學
機電工程學系
107
This paper presents a parameter study of the dip-drawing process of making high aspect-ratio polymeric microneedles. The process involves dip-pad spin coating, dip-drawing, UV-curing, necking, and breaking. To gain more insight into the process, we study three major process parameters including curing time, drawing speed, dip-mold’s tip diameter, they are critical parameters of the microneedle fabrication process. We also make different microneedles by setting a series of process parameters through dip-drawing platform. To prepare the experiment, we design an automatic dipping and drawing platform. The platform consists of a dip-mold holder, a dip-pad holder, a UV LED array, two stepping-motors, two threaded shaft systems, and a single board computer. The dip-mold is constructed of an acupuncture needle array. The dip-pad is prepared by spin-coating SU-8 (SU-2025). The single board computer acts as a human interface platform for a user to set up the dip-drawing process parameters including dip-drawing speed and curing time. User can operate this automatic platform to make various microneedles. The experiment results show that the dip-drawing process would yield sharpened high-aspect-ratio microneedles. At different drawing speeds, the radius of the microneedle tips gradually decreased with the increasing of the drawing speed. Under different UV curing time, the needle diameter decreased with the decreasing of curing time.
Gao, Shao Syuan, and 高紹軒. "Feasibility Assessment of Fabricating Polymeric Microneedle Array by Stepwise Drawing Technique." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/99r99r.
Повний текст джерела長庚大學
生化與生醫工程研究所
104
In this study, we expected to fabricate polymer-made microneedles (MNs) by stepwise drawing technique (SDT). The impact of morphology of MNs depends on the optimization of SDT, which includes the optimization of dispensing condition of peristaltic pump and drawing process. Multi-parameters adjustment of dispensing condition of MNs array was selected by model test and area of the base analysis. The characteristics of MN fabricated by different composition of dextran/maltose materials were investigated by stereomicroscope and scanning electron microscope. The results show that MNs with 875.83±54.3μm in height, 801.94±47μm in width and aspect ratio of 1.09 were fabricated by the polymer solution composed of 39% dextran and 1% maltose during 60 second of controlled drawing. MNs fabricated successfully via controlled drawing method were inserted into porcine cadaver skin to test the insertion capability and it is revealed that the insertion ratio was closed to 100%. In addition, optical coherence tomography (OCT) was used to observe the depth of MN puncture in real-time, the results showed that the penetration depth was about 400μm, which performed the sufficient mechanical strength to penetrate stratum corneum barrier. Furthermore, the skin recovery of porcine cadaver skin after puncture was also investigated by OCT, illustrating that indentation of the porcine cadaver skin tissue induced by MNs can recover after 260 minute. Rhodamine 6G (R6G)-loaded MN and FITC–insulin loaded MN were inserted into to porcine cadaver skins and to observe the in vitro transdermal delivery profiles by using confocal laser scanning microscope (CLSM). It is showed that the diffusion depth of R6G and FITC–insulin were about 460μm and 300μm after puncture for 10 min, respectively. Furthermore, in vitro transdermal delivery was performed by Franz diffusion cell to determine accumulated release profile of insulin. The result revealed that 88.2±2.69% of insulin was released within 7 hours from MN. SDT provides easy, convenient, and high-speed fabrication which could reduce MNs drying time and overcome the drawback of volume and drug loss in the 3D mold cavity. Optimization of the parameters of this technique may supply the possibility of MNs mass production in the future.
Lee, Horn-Chin, and 李鴻慶. "Fabrication of a Hollow Metallic Microneedle Array and a Micro-Electroporation Chip." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/80404571397871122332.
Повний текст джерела國立臺灣海洋大學
機械與機電工程學系
94
This thesis is focused on the design and fabrication of a hollow metallic microneedle array and electroporation chip using micro-electro-mechanical system (MEMS) technique. The fabrication process of the hollow metallic microneedle array was fairly simple and the expensive inductively coupled plasma etching was not required. Oxide and nitride was deposited on the Si substrate. The definition of square matrix pattern using reactive ion etching was used as the mask for wet etching. After the wet etching, array of solid microneedles with height of 300 �慆 was then electroformed and de-molded to complete the fabrication process. A drug reservoir made of PDMS was bonded together with the microneedle array to form a micro-injection system. The micro-injection system was tested on chicken skin tissue. Experimental results showed that the microneedles were robust and the system can be used for drug delivery The electroporation chip was demolded from a mold made from PMMA. A circular microchannel of diameter 250 �慆 was made possible by combining a optic fiber and the mold. Experimental result shows that the chip can fix a fish embryo cell by negative pressure through the channel. The associated deformation of the cell can increase the transmembrane potential and help form transient aqueous pores for better electroporation. Keywords: Hollow metallic microneedle array, electroporation chip
Indermun, Sunaina. "Pharma-engineering of multifunctional microneedle array device for application in chronic pain." Thesis, 2015. http://hdl.handle.net/10539/17385.
Повний текст джерелаChan, Yong-Shi, and 陳詠欣. "The Fabrication of Hollow Microneedle Array with Controlled Microstructure for Cell Delivery." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/257xd3.
Повний текст джерела國立臺灣大學
醫學工程學研究所
107
Microneedles are micro-scale needles that pierce into epidermis of skin to create micro-channel for drug delivery in a painless, minimally invasive way. With this micro-channel, we can address the limitation of transdermal method, which is the molecule of the drug must be small and oil-soluble to penetrate the stratum corneum barrier. The advantages of microneedles are avoiding drug degradation in stomach and liver, reducing the risk of infection, improving patient compliance due to minimal skin trauma, less pain, and sustaining drug release. The current types of microneedles include solid microneedles, coated microneedles, hollow microneedles, degradable microneedles, and hydro-forming microneedles. Cellular therapy is one of therapeutic medical therapy, which involves culturing and modifying cells in an in vitro sterilized environment. The cells will deliver to the body to restore damaged or missing cells and tissues in the body. Nowadays, the therapy mainly delivers the cells to the body by injection. In addition, there are some limitations by traditional injection. For example, the injection has a risk of infection, the patient''s compliance is low due to pain at injection, and injections could also cause cells are no room for growth. Therefore, in combining the advantages and disadvantages of the above two, in this study, polydimethylsiloxane (PDMS) was used as a material, engraved by laser engraving machine, to produce a hollow microneedle array mold. Polymethylmethacrylate (PMMA) was then used for filling, polymerization and demolding. Hollow microneedle arrays with different microstructures were successfully fabricated. The cells were cultured on the hollow microneedles. We used MTT Assay to test cell viability and the biocompatibility of the material. Then we used Live/Dead Staining to test the survival rate of the cells and we also observed the attachment of the cells on the hollow microneedles. The results show that PMMA hollow microneedles have good biocompatibility and the cells can be successfully attached to the microstructure of hollow microneedles. At the same time, the hollow microneedles were used as a carrier for cell delivery, and the cells were delivered to acellular tissue scaffolds prepared by a comprehensive acellular processing program in sequence of freeze-thaw, detergent and biological enzyme. This study confirmed that the cells can effectively enter the tissue via hollow microneedle carrier and growth well.
HUANG, MIN-HUI, and 黃敏惠. "Evaluation of dissolving microneedle array patch for transdermal delivery of antipsychotic drugs." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/x264t5.
Повний текст джерела元培醫事科技大學
生物科技暨製藥技術系碩士班
107
Drugs developed as transdermal delivery dosage form have advantages of easy to carry, ease for administration, avoiding first pass effect as well as providing topical or systemic therapeutic. However, low bioavailability is always occurred due to the hindrance of stratum corneum that is existed on the outer surface of skin. Strategies that could overcome the physiological barrier of stratum corneum on the outer surface of skin and harmless to tissue are the most important issues. In this study, we have developed a dissolving microneedle array patch with 10×10 microneedles on 8 mm×8 mm area. The shape of each microneedle was tetrahedral cone with 100×100 μm2 of basal area and 300 μm in length. The physical parameters with regard to hardness was measured as 24.93±3.12 N. The drug loaded patch with this hardness was confirmed could pierce the stratum corneum of the nude mouse skin. The melting point of model drug loaded in microneedle array patch was analyzed by differential scanning calorimetry (DSC). Similar melting point at 147-148 ℃ was observed when comparing Aripiprazole alone to formulated one. In addition, the results of Fourier-transform infrared spectroscope (FTIR) evaluation showed the wavenumber of model drug did not shift after formulated with patch excipients represented there no structure interaction between drug and excipients molecules. Loaded model drug may follow zero order released with the release rate of 244.31±30.71 ng/hr. The results of in vitro skin permeation study using Franz cell showed significant increase in apparent permeability coefficient of model drug loaded in microneedle array patch for 1.93×10-8 cm/sec compared to model drug alone. After patching drug loaded microneedle array on nude mice skin, blood samples were quantified by HPLC analysis. The results showed model drug behave sustained release properties. The pharmacokinetic parameters were analyzed with the non-compartment model and the conpartment model by using PK solver software. The results showed two-compartment mode was the best match. In vivo tissue analysis, the results show that the drug is distributed to various tissues, it also conforms to the two-compartment mode in the compartmental mode and the blood-tissue barrier system. In addition, model drug was quantified to distributed in the heart, lung, liver, spleen, stomach, kidney, duodenum, testis, brain and spinal cord. Among those issues, model drug showed relative slow distribution to blood-tissue barrier existed tissues including brain, spinal cord and testis.
Vinaya, Kumar K. B. "Design, Development and Performance Study of Microneedle & Micropump-based Transdermal Drug Delivery System." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/4092.
Повний текст джерелаLin, Chuan, and 林雋. "The design and fabrication of 3-D electroplated microneedle array with oblique shape." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/45604204310873727951.
Повний текст джерелаYu-LuenDeng and 鄧宇倫. "Investigation of Particle Movement Induced by AC Electrokinetics inside Microchannel with Microneedle Array." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/91229944832227210907.
Повний текст джерела國立成功大學
化學工程學系碩博士班
98
In the microfluidic systems, AC electrokinetics has been a common strategy to manipulate the fluid flow and particle motion, which leads to various applications such as separation, sample concentration and so on. From the literature, most of the electrode pair fabricated is two dimensional. Since the dielectrophoretic (DEP) force is proportional to the gradient of the square of electric field, 3-D design could extend the electrodes into the microchannel and provide the electric field inside the entire microchannel. In this study, we used an array of microneedles along with ITO glass to form the 3-D electrode pairs. The results show that, at lower particle concentration, the fluorescent particles aggregate faster at the tips of microneedles and the fluorescent intensity reaches the maximum in 10 seconds when only the tip of microneedles is conductive. AC electro-osmotic flow is observed at the lower frequency. As the particle concentration increases, an array of the pearl chain-like structure can be formed. Although the pearl chain-like structure can be formed when using the plane electrode, the distribution is not uniform.
PAI, YU-CHUAN, and 白育全. "A Novel Method To Fabricate IrOx Microneedle Array For Application On Electrophysiological Devices." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/zyb355.
Повний текст джерела國立臺北科技大學
材料科學與工程研究所
107
Medicine injection has raised attention in recent years. The skin compose by stratum corneum, dermis, and hypodermis layer. The requirement of microneedle arrays must have high aspect ratio, biocompatibility, and easy pirece the skin arrived at dermis layer of the length. In this work, we use three expose method of photolithography process to fabrication microneedle array, and we investigate relationship with the spin coating, photoresist viscosity, and exposure energy. It will influence the microneedle arrays structure. In addition, we utilize iridium and parylene C as the electrode and passivation materals, respectively. Subsequently we compare platinum and iridium oxide electrochemical characteristic, and use the optical microscope and scanning electron microscope to observe the surface morphology. Otherwise, we utilize the charge storage capacity(CSC) and electrochemical impedance spectroscopy to evaluate the reliability by soaking test. In addition, we characterized the resistivity of the platinum and iridium oxide film electrode by hall effect measuring. Finally, we would like to fabricate of the microneedle arrays can instead of the traditional needles and easy to pirece the skin into the dermis layer to achieve the purpose of painless injection. We also can obtain the electroencephalography(EEG), electrocardiography(ECG), electromyography(EMG) signal detection.
Lin, Yi-Jou, and 林儀柔. "A Two-Step Controlled Release System Based on The Microneedle array filled with pH-sensitive PLGA hollow microspheres (HMS) for transdermal drug delivery." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/28118117724661515154.
Повний текст джерела國立清華大學
奈米工程與微系統研究所
99
Transdermal delivery is an attractive alternative of drug delivery. Comparing to the conventional drug delivery techniques using pills or injections, this approach avoids degradation in the gastrointestinal tract and the pain of injections. But it is limited by the low permeability of skin because the stratum corneum (SC) in the upper skin (10-20 μm) is the main barrier. Hence, we used the Bio-MEMS technique to make microneedle array patch to inset into skin. This microneelde array patch could easily cross the SC but not so long that reach the deeper tissue and simulate nerves to developed a convenient, pain-free, and high efficient transdermal delivery patch. In this study, we present a novel approach to transdermal drug delivery that is two-step controlled-release system based on the skin cancer application. We used fluorescent dyes as model drugs to simulate the slow effect of anti-cancer drug and short half-time of anesthesia and vasoconstrictor. First, we used backside exposure technology of UV-lithography to fabricate microneedle array mold and bio-available PVP polymer with 1st model drug as the microneedle array materal. Second, we used double emulsion technology to fabricate pH-sensitive PLGA HMS (Hollow Micro-Spheres) with 2nd model drug. Sequentially, we combined these two techniques to fabricate the two-step controlled-release microneedle patch. This microneedle patch was shown two-step releasing profiles in vitro, the insertion capability ex vivo, and the transcutaneous delivery in vivo. As a consequence, we conclude that the two-step controlled-release can release two drugs with a time difference to the skin.
Wu, Jia-Yong, and 吳嘉鏞. "Design and Fabrication of Microneedle Arrays for Drug Delivery." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/38578235678897763356.
Повний текст джерела國立高雄應用科技大學
機械與精密工程研究所
102
With advances in technology and medicine, the microneedles for painless treatment are used to pierce the skin for drug delivery and vaccination. Some scholars found that the microneedle of less than 150 μm in length would not cause pain form patients in use. With the drug patches the hydrophilic drug molecules can pass the stratum corneum to deliver the drug quickly. In this study, we investigated the use of micro-electromechanical systems (MEMS) technology for fabrication of micron nickel metal needles. Using positive photoresist (AZ4620) and negative photoresist (SU8-50), different combination of photoresists were explored for the fabrication process. Photolithography was applied to fabricate the SU-8 photoresist mold in the stainless steel sheet, and then nickel metal was electroformed onto the photoresist mold. Finally Remover PG removed the photoresist SU-8 and then nickel microneedles were released. We successfully fabricated microneedle patches. The microneedles were in array of 5×5, in which the center spacing of two needles was 2.25 mm, the inner diameter of microneedle was 0.1 mm, the outside diameter of microneedle was 0.75 mm, and the length of microneedle was 100 ~ 150 μm. The microneedle layer and nozzle plate did not separate under bending tests. In the liquid transport experiment, the microneedle patch transmitted liquid successfully.
Jhou, San-Jie, and 周三傑. "A Mathematical Two-Dimensional Model Accounting for Transdermal Diffusion with Microneedles Array." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/66062259120277439401.
Повний текст джерела國立中興大學
化學工程學系所
102
In transdermal drug delivery, the stratum corneum is the enormous resistance. To effectively permeate the drug into the human skin, the studies had been proposed after the approaches of permeable enhancement had researched. These approaches was categorized to chemical and physical. Recently, the dramatical approach which was physical enhancement, can pierce the stratum corneum with microneedles. Because it directly crossed the permeability barrier, accompanied the coated drug can effectively get into the human body. Literature reported that used the biodegradability materials to fabricate the microneedles and the drug was encapsulated within the microneedles. In this way, it can not only assist the drug delivery, but also control drug release at targeting site. And it was without pain or biohazardous in human body. By this literature, the approach with microneedles can pierce the stratum corneum such that the drug get into the body without resistance. If used dissolved microneedles, then increased the controlled drug release function and without pain and hurt for human. Therefore, this work used a mathematicl two-dimensional model accounting for drug diffusion with microneedles array and fixed the number of microneedles to compare that increased the points in one direction more than other will have the best effective, as well as, compared to single microneedle. Among of different arrangements, the diffusion with increasing the number of microneedles in the direction of ρ was more effectively than the direction of θ. Finally, all of the arrangement with many microneedles were better than the model with single microneedle.
Ching-FengLai and 賴鏡峰. "Design and Simulation of Microneedle Arrays for Transdermal Drug Delivery by Electroporation." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/y7ky97.
Повний текст джерела國立成功大學
生物醫學工程學系
107
Transdermal drug delivery is one of the most efficiency way in transporting drug into human body. Compared to traditional method, transdermal drug delivery features in fast, less side effect, specific drug control. In modern medicine, the main idea not only focus on the efficiency of treatment but also puts emphasize at patient’s feeling. Microneedle can reduce painful feeling apparently compares to traditional subcutaneous injection due to its small diameter. Furthermore, microneedle is an effective tool which has been under developed in past decades. Besides drug delivery, microneedle can applied to gene therapy, target treatment against cancer especially for carcinoma and for vaccine. Microneedle can be divided into several types due to its pathway such as hollow, coat and poke, dissolving. Hollow microneedle combines with microfluidic and microneedle patch form a whole device. Although hollow microneedle reveals good efficiency in drug delivery, there are still some disadvantages. In this article, the aim is addressing design concept of “coat and poke” microneedle which combines with electric field. “Coat and poke” microneedle type is with protein-based drug coated or DNA-based vaccine at the surface of microneedle. As microneedle is made of metal material which is electrically conductive, it can exert electric field in human skin conducts electroporation to enhance efficiency of drug delivery. Furthermore, microneedle is in micro diameter (100~500μm) while it provides sufficient mechanical strength to penetrate skin without mechanical fracture and prevent patient feeling painful. In this study, microneedle with shorter length(〈200 μm) and larger wall angle(〉8°) show the greater ability to resist mechanical failure. Besides diameter, material selection is also a critical factor of design. Three types of material are chosen which are, Titanium Beta-21S, Stainless Steel 316L, Ni-Co-Cr-Mo alloy. Among these materials, Titanium Beta-21S shows the widest range of application so this material is recommended to microneedle application. To evaluate efficiency of drug delivery, diluted species and electric field distribution are important things for indicating which kinds of microneedle is better. Three kinds of design are applied, rectangular array, hexagon array with 4 potentials and hexagon array with 6 potentials. From the simulation result, hexagon array with 4 potentials can provide the largest effective volume formed by concentration and electric field at time=9s so that it reveals the appropriate moment to conduct electric field to reach greater efficiency. Combined with different physics, this study addresses design concept of microneedle array and hope that it can be applied in future.
Guo, Ming-Sheng, and 郭銘勝. "Study on the microneedle arrays for transdermal drug delivery using wet etch technology." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/25695538350383571465.
Повний текст джерела國立臺灣海洋大學
輪機工程系
93
Generally for treatment, it may use the syringes to inject drug but always cause human body to get pain. Therefore there were many successive studies of microneedles for human body to avoid getting pain and also to deliver drug. There is no pain of human body due to microneedle without exciting the end of nerve. The great number of blood capillaries of the human body increases the absorption of medicine. To use the silicon wafer with crystalline grain direction (100) and simple mark, the out-of-plane microneedle arrays with 460 μm in height can be done by the technology of MEMS. The PDMS (polydimethylsilox -ane) container, a reservoir of the transdermal drug, can be used with the microneedle arrays having a vias on the silicon to deliver the medicine.
Hsu, Wei Chieh, and 徐偉傑. "Fast fabrication methods with controllable height and width of microneedle arrays for transdermal drug delivery." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/32503184518996863218.
Повний текст джерела長庚大學
電子工程學系
102
Transdermal drug delivery system is new method to deliver drugs to human body by Diffusion, however the high-molecular-weight drugs isdifficult to go through the skin due to stratum corneum, the purpose of the stratum corneum is to form a barrier to protect underlying tissue from infection, dehydration, chemicals and mechanical stress, in order to overcome this skin barrier, microneedles offer a minimally invasive method, Microneedles are physical enhancers for transdermal drug delivery designed to increase the permeability of drugs into the skin by passing the stratum corneum. In this study, we use UV glue droplet combine with actuator to fabricate microneedle, we use different baking time to transform Viscosity of UV glue droplet and control actuator’s path and velocity to fabricate different length and width of microneedle. According to the results, baking time 3min can fabricate about 700 µm microneedle, we believe 700 µm microneedle can insert human skin to overcome stratum corneum barrier. Compare with tradition method, we purpose very easy method to fabricate microneedle and fabrication time is very short, we only need 30 minutes to complete the process. We believe that the approach we provided in this research was a easy and quick method for the microneedle fabrication.