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Добірка наукової літератури з теми "Microfluidics paper-based analytical device"

Автор: Grafiati
Опубліковано: 11 березня 2023

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Статті в журналах з теми "Microfluidics paper-based analytical device"

1

Coltro, Wendell. "Paper-based microfluidics: What can we expect?" Brazilian Journal of Analytical Chemistry 9, no. 37 (October 5, 2022): 11–13. http://dx.doi.org/10.30744/brjac.2179-3425.point-of-view-wktcoltro.n37.

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Анотація:
In the last three decades, the scientific community has observed exponential growth in the development of microfluidic platforms and their use for applications in different fields. The noticeable advances are attributed to the advantages provided by miniaturization.1 In summary, the downscaling of analytical devices has offered attractive features, including reduced consumption of samples and reagents, short analysis time, and minimal waste generation. In addition, the possibility to perform multiplexed assays in portable devices without bulky instrumentation is another attractive feature that boosted the investigation of miniaturized devices with the capability to be tested directly in the point-of-care (POC). Due to the sample volume required to proceed with a chemical analysis on a microscale (typically in the µL range), a complete understanding of the fluid control and handle on channels defined in micrometric dimensions was necessary, giving rise to the science known as microfluidics.2 Many platforms including rigid and flexible materials can be explored for manufacturing microfluidic networks. Among all the substrates reported in the literature, the “paper” is by far the simplest and cheapest material currently employed for the development of microfluidic devices dedicated to analytical, bioanalytical, biomedical, environmental, food, and forensics applications.3 For many readers, the first question is why paper is used instead of other materials such as glass. Well, glass is a rigid material, and microchannel engraving requires cleanroom facilities, photolithographic patterning, developing steps, and thermal sealing. This standard protocol makes use of sophisticated instrumentation, and it is not readily available to most researchers. In this way, paper emerges as a simple and alternative material to be used for microfluidics. One of the major benefits of microfluidics refers to the sample-in-answer-out capability, which requires a fully automated fluid control to allow sample preparation, analytical separation, and detection stages. The fluid-controlled handling inside microchannels opens the possibility to integrate multiple analytical tasks in parallel into a high-throughput device. Considering these possibilities, it is worthwhile reflecting on how paper can be used to transport and handle a fluid. Paper is currently one of the most widely used raw materials in research laboratories. Its use has been explored for over a century. In 1949, a paper containing barriers made of paraffin was exploited to successfully demonstrate the elution of pigments within a channel based on the sample diffusion process.4 In 2007, paper was reinvented by the Whitesides group as a globally affordable substrate material for the development of miniaturized analytical platforms.5 Since this period, paper has become an increasingly popular platform for multipurpose applications. Probably, its broad use is associated with advantages over other conventional substrates, as well as the fabrication technologies and the concept of “do-it-yourself microfluidics”.6 In comparison with other conventional materials, like glass and silicon, paper is relatively inexpensive, globally affordable, lightweight, bioactive, and easy to transport and store. Furthermore, paper-based products can be easily found as kitchen towels, coffee filters, blood separation paper, filter paper, office paper, and others. How does one create an analytical device on paper? This question is a common inquiry of undergraduate and graduate students when starting to study microfluidics. Initially, it is important to emphasize that paper substrates have a porous structure, which facilitates the spontaneous transport of fluid by capillarity. The wicking speed of liquid on a microchannel defined on paper depends on pore size and paper thickness. Microfluidic networks can be created on paper using hydrophobic barriers or defined by cutting approaches, which make it possible to obtain single paper strips or more complex designs containing interconnected microchannels for multiplexed assays3. In this regard, lithography-based fabrication methods were first employed to demonstrate the potential of paper substrates for developing microfluidic structures. However, due to the contradictory view in terms of cost, many other alternative approaches were developed to make affordable and popular the concept and potential of paper-based microfluidics. Thanks to the researchers´ creativity and paper versatility, the fabrication of microfluidic paper-based analytical devices is feasible through direct printing using wax, inkjet, or laser printing processes or even by manual protocols (freehand drawing or spraying) involving pens, pencils, stamps, scissors, scholar’s glue, or lacquer resins. Paper-based microfluidic devices, including examples of simple spot test arrays, chemosensors, biosensors, electrochemical sensors, wearable devices, and lateral flow assays, have been found in the main scientific Journals associated with analytical and bioanalytical chemistry.7-10 In the academy, most of the advances seen in the recent literature have demonstrated improvements in terms of durability, shelf life, reproducibility, robustness, and analytical reliability, making paper-based microfluidic devices promising and emerging candidates to gain space in the market as alternatives to other materials. In this way, entrepreneurship and innovation deserve to be highlighted and emerge as the focus of many researchers interested in opening their businesses or company. The bridge between the academy and the productive sector depends on investment and engagement to overcome administrative and legal bureaucracies not only to open a company but also to maintain it in full operating mode. The commercialization of microfluidic devices has been constantly growing. In the last three years, for example, many companies located in different countries have shipped over five hundred million units/year, clearly demonstrating the potential of microfluidic devices for different application areas including drug delivery, flow chemistry, analytical devices, pharmaceutical and life science, point-of-care diagnostics and clinical and veterinary settings.11 Considering the advantages of paper-based materials, what can we expect in the coming years? Commercially available products with sample-in-answer-out capabilities are highly desirable to be found more and more in the market. Due to the global affordability of paper as well as its attractive features to create microfluidic and sensor prototypes, it is possible to see a real niche full of possibilities for success. In this view, it is time to try our best and make commercially available paper-based products like wearable sensors or lateral flow devices to monitor clinically relevant compounds in different biological fluids like blood, urine, serum, sweat, saliva, and tears. This may be accelerated by spin-offs or startups independently or in partnership with well-established companies. In other words, it is time to innovate and transform an idea into a commercial product with a societal impact. The interface between rapid tests and immediate responses directly by the end user are highly desirable features in the market and risk analysis. The SARS-CoV-2 worldwide outbreak is the most recent example that science can offer the possibility to obtain clinical diagnostics in a matter of minutes, allowing one to decide on the ideal treatment or, in this case, social isolation to prevent the virus transmission. Tens of self-diagnostics kits based on paper strips for SARS-CoV-2 are already commercially available for society in drug shops, hospitals, or healthcare clinics. Similar strategies may be seen shortly for Monkeypox or other global outbreaks.
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2

Catalan-Carrio, Raquel, Tugce Akyazi, Lourdes Basabe-Desmonts, and Fernando Benito-Lopez. "Predicting Dimensions in Microfluidic Paper Based Analytical Devices." Sensors 21, no. 1 (December 26, 2020): 101. http://dx.doi.org/10.3390/s21010101.

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The main problem for the expansion of the use of microfluidic paper-based analytical devices and, thus, their mass production is their inherent lack of fluid flow control due to its uncontrolled fabrication protocols. To address this issue, the first step is the generation of uniform and reliable microfluidic channels. The most common paper microfluidic fabrication method is wax printing, which consists of two parts, printing and heating, where heating is a critical step for the fabrication of reproducible device dimensions. In order to bring paper-based devices to success, it is essential to optimize the fabrication process in order to always get a reproducible device. Therefore, the optimization of the heating process and the analysis of the parameters that could affect the final dimensions of the device, such as its shape, the width of the wax barrier and the internal area of the device, were performed. Moreover, we present a method to predict reproducible devices with controlled working areas in a simple manner.
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3

Meredith, Nathan A., Casey Quinn, David M. Cate, Thomas H. Reilly, John Volckens, and Charles S. Henry. "Paper-based analytical devices for environmental analysis." Analyst 141, no. 6 (2016): 1874–87. http://dx.doi.org/10.1039/c5an02572a.

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4

Juang, Yi-Je, and Shu-Kai Hsu. "Fabrication of Paper-Based Microfluidics by Spray on Printed Paper." Polymers 14, no. 3 (February 8, 2022): 639. http://dx.doi.org/10.3390/polym14030639.

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Анотація:
Since the monumental work conducted by Whitesides et al. in 2007, research and development of paper-based microfluidics has been widely carried out, with its applications ranging from chemical and biological detection and analysis, to environmental monitoring and food-safety inspection. Paper-based microfluidics possesses several competitive advantages over other substrate materials, such as being simple, inexpensive, power-free for fluid transport, lightweight, biodegradable, biocompatible, good for colorimetric tests, flammable for easy disposal of used paper-based diagnostic devices by incineration, and being chemically modifiable. Myriad methods have been demonstrated to fabricate paper-based microfluidics, such as solid wax printing, cutting, photolithography, microembossing, etc. In this study, fabrication of paper-based microfluidics was demonstrated by spray on the printed paper. Different from the normally used filter papers, printing paper, which is much more accessible and cheaper, was utilized as the substrate material. The toner was intended to serve as the mask and the patterned hydrophobic barrier was formed after spray and heating. The processing parameters such as toner coverage on the printing paper, properties of the hydrophobic spray, surface properties of the paper, and curing temperature and time were systematically investigated. It was found that, after repetitive printing four times, the toner was able to prevent the hydrophobic spray (the mixture of PDMS and ethyl acetate) from wicking through the printing paper. The overall processing time for fabrication of paper-based microfluidic chips was less than 10 min and the technique is potentially scalable. Glucose detection was conducted using the microfluidic paper-based analytical devices (µPADs) as fabricated and a linear relationship was obtained between 1 and 10 mM.
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5

Ozer, Tugba, Catherine McMahon, and Charles S. Henry. "Advances in Paper-Based Analytical Devices." Annual Review of Analytical Chemistry 13, no. 1 (June 12, 2020): 85–109. http://dx.doi.org/10.1146/annurev-anchem-061318-114845.

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Анотація:
Microfluidic paper-based analytical devices (μPADs) are the newest generation of lab-on-a-chip devices and have made significant strides in both our understanding of fundamental behavior and performance characteristics and expansion of their applications. μPADs have become useful analytical techniques for environmental analysis in addition to their more common application as medical point-of-care devices. Although the most common method for device fabrication is wax printing, numerous other techniques exist and have helped address factors ranging from solvent compatibility to improved device function. This review highlights recent reports of fabrication and design, modes of detection, and broad applications of μPADs. Such advances have enabled μPADs to be used in field and laboratory studies to address critical needs in fast, cheaper measurement technologies.
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6

Lim, Jafry, and Lee. "Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices." Molecules 24, no. 16 (August 7, 2019): 2869. http://dx.doi.org/10.3390/molecules24162869.

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Анотація:
Paper-based microfluidic devices have advanced significantly in recent years as they are affordable, automated with capillary action, portable, and biodegradable diagnostic platforms for a variety of health, environmental, and food quality applications. In terms of commercialization, however, paper-based microfluidics still have to overcome significant challenges to become an authentic point-of-care testing format with the advanced capabilities of analyte purification, multiplex analysis, quantification, and detection with high sensitivity and selectivity. Moreover, fluid flow manipulation for multistep integration, which involves valving and flow velocity control, is also a critical parameter to achieve high-performance devices. Considering these limitations, the aim of this review is to (i) comprehensively analyze the fabrication techniques of microfluidic paper-based analytical devices, (ii) provide a theoretical background and various methods for fluid flow manipulation, and iii) highlight the recent detection techniques developed for various applications, including their advantages and disadvantages.
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7

Channon, Robert B., Michael P. Nguyen, Alexis G. Scorzelli, Elijah M. Henry, John Volckens, David S. Dandy, and Charles S. Henry. "Rapid flow in multilayer microfluidic paper-based analytical devices." Lab on a Chip 18, no. 5 (2018): 793–802. http://dx.doi.org/10.1039/c7lc01300k.

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Multilayer paper devices are used to generate fast flow rates (1.56 cm s−1) which are 145-fold quicker than classical single-layer paper device designs. These self-pumping devices are demonstrated for the sequential injection stripping analysis of cadmium.
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8

Li, Qi, Xingchen Zhou, Qian Wang, Wenfang Liu, and Chuanpin Chen. "Microfluidics for COVID-19: From Current Work to Future Perspective." Biosensors 13, no. 2 (January 20, 2023): 163. http://dx.doi.org/10.3390/bios13020163.

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Анотація:
Spread of coronavirus disease 2019 (COVID-19) has significantly impacted the public health and economic sectors. It is urgently necessary to develop rapid, convenient, and cost-effective point-of-care testing (POCT) technologies for the early diagnosis and control of the plague’s transmission. Developing POCT methods and related devices is critical for achieving point-of-care diagnosis. With the advantages of miniaturization, high throughput, small sample requirements, and low actual consumption, microfluidics is an essential technology for the development of POCT devices. In this review, according to the different driving forces of the fluid, we introduce the common POCT devices based on microfluidic technology on the market, including paper-based microfluidic, centrifugal microfluidic, optical fluid, and digital microfluidic platforms. Furthermore, various microfluidic-based assays for diagnosing COVID-19 are summarized, including immunoassays, such as ELISA, and molecular assays, such as PCR. Finally, the challenges of and future perspectives on microfluidic device design and development are presented. The ultimate goals of this paper are to provide new insights and directions for the development of microfluidic diagnostics while expecting to contribute to the control of COVID-19.
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9

Mentele, Mallory M., Josephine Cunningham, Kirsten Koehler, John Volckens, and Charles S. Henry. "Microfluidic Paper-Based Analytical Device for Particulate Metals." Analytical Chemistry 84, no. 10 (April 26, 2012): 4474–80. http://dx.doi.org/10.1021/ac300309c.

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Kugimiya, Akimitsu, Akane Fujikawa, Xiao Jiang, Z. Hugh Fan, Toshikazu Nishida, Jiro Kohda, Yasuhisa Nakano, and Yu Takano. "Microfluidic Paper-Based Analytical Device for Histidine Determination." Applied Biochemistry and Biotechnology 192, no. 3 (June 27, 2020): 812–21. http://dx.doi.org/10.1007/s12010-020-03365-z.

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Дисертації з теми "Microfluidics paper-based analytical device"

1

Murdock, Richard C. "Development of Microfluidic Paper-based Analytical Devices for Point-of-Care Human Physiological and Performance Monitoring." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439308025.

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2

Klasner, Scott A. "Novel capillary and microfluidic devices for biological analyses." Diss., Manhattan, Kan. : Kansas State University, 2010. http://hdl.handle.net/2097/3747.

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3

Kripalani, Rishi A. "Novel Integration of Conductive-ink Circuitry with a Paper-based Microfluidic Battery as an All-printed Sensing Platform." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1694.

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The addition of powered components for active assays into paper-based analytical devices opens new opportunities for medical and environmental analysis in resource-limited applications. Current battery designs within such devices have yet to adopt a ubiquitous circuitry material, necessitating investigation into printed circuitry for scalable platforms. In this study, a microfluidic battery was mated with silver-nanoparticle conductive ink to prototype an all-printed sensing platform. A multi-layer, two-cell device was fabricated, generating 200 μA of direct electrical current at 2.5 V sustained for 16 minutes with a power loss of less than 0.1% through the printed circuitry. Printed circuitry traces exhibited resistivity of 75 to 211 10-5 Ω m. Resistance of the printed traces increased upwards of 200% depending on fold angle and directionality. X-ray diffraction confirmed the presence of face-centered cubic silver after sintering printed traces for 30 minutes at 150°C in air. A conductivity threshold was mapped and an ink concentration of 0.636 μL mm-3 was identified as the lower limit for optimal electrical performance.
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4

Liu, Cheyenne H. "Development and Characterization of Reagent Pencils for Microfluidic Paper Based Analytical Devices." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1639.

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Microfluidic paper based analytical devices (microPADs) are a novel platform for point of care (POC) diagnostics. Limitations of reagent shelf life have been overcome with the introduction of reagent pencils as a method for solid-based reagent deposition. While useful, little work has been reported on the characterization and optimization of reagent pencils. Herein, an investigation on reagent pencil composition and efficiency is conducted via colorimetric release profile tests utilizing an erioglaucine disodium salt that yields a quantifiable blue colored product in the presence of water. Within this work, an investigation on the molecular weight dependence, polymer chain end functionality, and polymer-graphite ratio was conducted to determine the most desirable parameters in reagent pencil composition. Further, the effects of enzyme stability in the presence of poly(ethylene glycol) (PEG) is investigated. To show the versatility of reagent pencils, a novel reagent pencil incorporating a stimuli responsive polymer, poly(N-isporopylacrylamide) (PNIPAM) was developed. In this work, PNIPAM’s lower critical solution temperature (LCST) was manipulated with various salt solutions to control fluid flow both laterally and vertically through various microPAD designs. It was found that, while PNIPAM successfully blocked or retarded fluid flow in microPADs, the effect was limited when DI H2O wash solutions were run prior to salt solutions. To counteract this, PNIPAM was successfully covalently bound to alkene modified chromatography paper via thiolene click chemistry to reinforce solution wash tolerance.
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5

Nguyen, Vina, and Vina Nguyen. "Microfluidic Paper Analytic Device for Assessment of Blood Coagulation." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/624139.

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Monitoring blood coagulation while a patient is on cardiopulmonary bypass (CPB) is critical in preventing clots from arising in the bypass machine and consequently being sent into the patient’s bloodstream. Current methods used to monitor blood coagulation such as Activated Clotting Time (ACT) yield results that do not correlate coagulation time to heparin or protamine dosage and will typically take at least 400 s to yield a result that is safe to initiate bypass. Microfluidic paper-based analytical devices (μPAD) are advanced sensors based on a wide range of recently developed techniques for complex analytical methods. In this research, a point-of-care (POC) sensor was developed based on techniques adapted from lateral flow and µPAD. The effects of varied dosages of heparin and protamine were observed using this POC µPAD and an accompanying Raspberry pi-based monitoring device. Paper microfluidic channels were printed on nitrocellulose paper with a wax pattern. Human whole blood was added to an absorbent fiber glass sample pad preloaded with known amount of heparin or protamine. By having this absorbent pad on the inlet of the channel, the blood sample is able to travel through the channel via capillary flow. Significantly different (p < 0.05) rates of flow between blood samples with different doses of heparin and protamine show that the device can monitor the extent of coagulation and patient-specific responses to each drug. Thus a low-cost device was built that monitors the extent of blood coagulation and allows for individualized dosing of heparin and protamine in as little at 20 s and no more than 180 s.
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6

Mitchell, Haydn Thomas. "AN INVESTIGATION OF POLY(N-ISOPROPYLACRYLAMIDE) FOR APPLICATIONS WITH MICROFLUIDIC PAPER-BASED ANALYTICAL DEVICES." DigitalCommons@CalPoly, 2014. https://digitalcommons.calpoly.edu/theses/1248.

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N,N′-methylenebisacrylamide-crosslinked poly(N-isopropylacrylamide), also known as P(NIPAM), was developed as a fluid delivery system for use with microfluidic paper-based analytical devices (microPADs). MicroPADs are postage-stamp-sized devices made out of paper that can be used as platforms for low-cost, simple-to-use point-of-care diagnostic assays. P(NIPAM) is a thermally responsive polymer that absorbs aqueous solutions at room temperature and will expel the solutions to microPADs when heated. The fluid delivery characteristics of P(NIPAM) were assessed, and P(NIPAM) was able to deliver multiple solutions to microPADs in specific sequences or simultaneously in a laminar-flow configuration. P(NIPAM) was then shown to be suitable for delivering four classes of reagents to microPADs: small molecules, enzymes, antibodies and DNA. P(NIPAM) successfully delivered a series of standard concentrations of glucose (0 – 5 mM) to microPADs equipped to perform a colorimetric glucose assay. The results of these tests were used to produce an external calibration curve, which in turn was used to determine accurately the concentrations of glucose in sample solutions. P(NIPAM) successfully delivered fluorescein-labeled IgG and fluorescein-labeled oligonucleotides (20 base pairs) to microPADs in a variety of concentrations. P(NIPAM) also successfully delivered horseradish peroxidase (HRP) to microPADs, and it was determined that HRP could be stored in P(NIPAM) for 35 days with minimal loss in activity. The combination of P(NIPAM) with microPADs will allow for more complex assays to be performed with minimal user input, will facilitate the preparation of external calibration curves in the field, and may be useful in extending the shelf life of microPADs by stabilizing reagents.
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7

Schultz, Spencer A. "An Investigation into the Use of Polymer Bound Boronic Acid for Glucose Detection in Paper Based Microfluidic Devices." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1611.

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Paper Based Microfluidic Devices (microPADs) are a new platform for point-of-care diagnostic assays for use in resource-limited settings. These devices rely typically on enzymatic assays to produce their results, which makes them susceptible to degradation when exposed to extreme environmental conditions such as high temperature. In order to overcome this limitation, this research project focused on investigating the use of polymers instead of enzymes to detect analytes on microPADs. Polymer-bound boronic acid, a glucose and pH sensitive polymer, was incorporated into microPADs in order to develop a chronometric, paper-based glucose assay. The polymer was tested with both lateral and vertical flow microPADs made from three different types of paper, and several different methods of incorporating the polymer into the devices were also explored. While some devices appeared to show a trend in signal versus concentration of glucose, none of the results were statistically significant due to the large standard deviations in the signal. Upon further analysis of the results, the overall conclusion was that the devices were not sensitive enough to detect glucose in the range of concentrations that would be practical for clinical diagnostic applications.
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8

Busin, Valentina. "The development of microfluidic paper-based analytical devices for point-of-care diagnosis of sheep scab." Thesis, Heriot-Watt University, 2017. http://hdl.handle.net/10399/3263.

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The recent growing interest and development of microfluidic paper-based analytical devices (μPADs) for point-of-care (POC) testing in human health in low-resource settings has great potential for the exploitation of these technologies in animal disease diagnosis. Sheep scab is a highly infectious, widespread and notifiable disease of sheep, which poses major economic and welfare concerns for the UK farming industry. The possibility of diagnosing sheep scab at the POC is, consequently, very important to controlling this disease. The overall aim of this project was, therefore, to develop μPADs based on a novel method of fabrication, in order to translate the existing lab-based sheep scab ELISA (Pso o 2) and a biomarker test for haptoglobin (Hp) into paper-based ELISA (P-ELISA), to enable POC diagnosis of this animal disease. In Chapter 3, the novel fabrication method is described, in Chapters 4 and 5, the translation of the lab-based ELISAs (Hp and Pso o 2 respectively) are explained and in Chapter 6 the development of a μPAD for incorporation of the POC tests into a multiplexed, rapid assay is covered. Experiments showed that both ELISAs were successfully transferred onto paper and that the devices developed were suitable for POC testing. This study has resulted in a novel fabrication method for μPADs, in successfully translated existing ELISAs to P-ELISA and in novel solutions for the POC diagnosis of an important veterinary disease.
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9

Chaplan, Cory A. "Stabilization of Horseradish Peroxidase Using Epoxy Novolac Resins for Applications with Microfluidic Paper-Based Analytical Devices." DigitalCommons@CalPoly, 2014. https://digitalcommons.calpoly.edu/theses/1252.

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Анотація:
Microfluidic paper-based analytical devices (microPADs) are an emerging platform for point-of-care diagnostic tests for use by untrained users with potential applications in healthcare, environmental monitoring, and food safety. These devices can be developed for a multitude of different tests, many of which employ enzymes as catalysts. Without specialized treatment, some enzymes tend to lose their activity when stored on microPADs within 48 hours, which is a major hurdle for taking these types of devices out of the laboratory and into the real world. This work focused on the development of simple methods for stabilizing enzymes by applying polymers to chromatography paper. The longterm stabilization was exlored and SU-8 of various concentrations was found to stabilize horseradish peroxidase for times in excess of two weeks. A variety of microPAD fabrications, enzyme dispensing methods, and substrate delivery techniques were explored.
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10

Zangheri, Martina <1987&gt. "Ultrasensitive chemiluminescence bioassays based on microfluidics in miniaturized analytical devices." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6999/1/Zangheri_Martina_tesi.pdf.

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The activity carried out during my PhD was principally addressed to the development of portable microfluidic analytical devices based on biospecific molecular recognition reactions and CL detection. In particular, the development of biosensors required the study of different materials and procedures for their construction, with particular attention to the development of suitable immobilization procedures, fluidic systems and the selection of the suitable detectors. Different methods were exploited, such as gene probe hybridization assay or immunoassay, based on different platform (functionalized glass slide or nitrocellulose membrane) trying to improve the simplicity of the assay procedure. Different CL detectors were also employed and compared with each other in the search for the best compromise between portability and sensitivity. The work was therefore aimed at miniaturization and simplification of analytical devices and the study involved all aspects of the system, from the analytical methodology to the type of detector, in order to combine high sensitivity with easiness-of-use and rapidity. The latest development involving the use of smartphone as chemiluminescent detector paves the way for a new generation of analytical devices in the clinical diagnostic field thanks to the ideal combination of sensibility a simplicity of the CL with the day-by-day increase in the performance of the new generation smartphone camera. Moreover, the connectivity and data processing offered by smartphones can be exploited to perform analysis directly at home with simple procedures. The system could eventually be used to monitor patient health and directly notify the physician of the analysis results allowing a decrease in costs and an increase in the healthcare availability and accessibility.
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Книги з теми "Microfluidics paper-based analytical device"

1

Krishnendu, Chakrabarty, and Zeng Jun, eds. Design automation methods and tools for microfluidics-based biochips. Dordrecht: Springer, 2006.

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2

(Editor), Krishnendu Chakrabarty, and Jun Zeng (Editor), eds. Design Automation Methods and Tools for Microfluidics-Based Biochips. Springer, 2006.

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Частини книг з теми "Microfluidics paper-based analytical device"

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Handa, Shristi, Vibhav Katoch, and Bhanu Prakash. "Microfluidic Paper-Based Analytical Devices for Glucose Detection." In Advanced Microfluidics-Based Point-of-Care Diagnostics, 61–98. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003033479-3.

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Seetasang, Sasikarn, and Takashi Kaneta. "Analytical Devices with Instrument-Free Detection Based on Paper Microfluidics." In Advanced Microfluidics-Based Point-of-Care Diagnostics, 249–70. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003033479-10.

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Wagh, Mrunali D., S. B. Puneeth, Subhendu Kumar Sahoo, and Sanket Goel. "Wax-Printed Microfluidic Paper Analytical Device for Viscosity-Based Biosensing in a 3D Printed Image Analysis Platform." In Microactuators, Microsensors and Micromechanisms, 301–9. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-20353-4_26.

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Shi, Zhuan Zhuan, Yao Lu, and Ling Yu. "Microfluidic Paper-Based Analytical Devices for Point-of-Care Diagnosis." In Next Generation Point-of-care Biomedical Sensors Technologies for Cancer Diagnosis, 365–96. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4726-8_16.

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Vishwakarma, Niraj K., Parul Chaurasia, Pranjal Chandra, and Sanjeev Kumar Mahto. "Microfluidics Devices as Miniaturized Analytical Modules for Cancer Diagnosis." In Advanced Microfluidics-Based Point-of-Care Diagnostics, 229–48. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003033479-9.

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Matson, Dean W., Peter M. Martin, Wendy D. Bennett, Dean E. Kurath, Yuehe Lin, and Donald J. Hammerstrom. "Fabrication Processes for Polymer-Based Microfluidic Analytical Devices." In Micro Total Analysis Systems ’98, 371–74. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-5286-0_88.

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Oliveira, Karoliny Almeida, Fabrício Ribeiro de Souza, Cristina Rodrigues de Oliveira, Lucimeire Antonelli da Silveira, and Wendell Karlos Tomazelli Coltro. "Microfluidic Toner-Based Analytical Devices: Disposable, Lightweight, and Portable Platforms for Point-of-Care Diagnostics with Colorimetric Detection." In Methods in Molecular Biology, 85–98. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-2172-0_6.

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Giri, Basant. "Determination of Nitrite Ions in Water Using Paper Analytical Device." In Laboratory Methods in Microfluidics, 83–88. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-813235-7.00013-1.

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Faheem, Aroosha, and Stefano Cinti. "Advanced techniques for manufacturing paper-based microfluidic analytical devices." In Microfluidic Biosensors, 159–70. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-12-823846-2.00009-2.

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Linnes, Jacqueline C., and Elizabeth Phillips. "Printed Wax-Ink Valves for Multistep Assays in Paper Analytical Devices." In Diagnostic Devices with Microfluidics, 65–74. CRC Press, 2017. http://dx.doi.org/10.1201/9781315154442-4.

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Тези доповідей конференцій з теми "Microfluidics paper-based analytical device"

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Lu, Chuan-Pin, Bo-Xian Guo, Zi-Qing Fang, and Shu-Chiang Chung. "The development of image base, portable microfluidic paper-based analytical device." In 2015 International Conference on Orange Technologies (ICOT). IEEE, 2015. http://dx.doi.org/10.1109/icot.2015.7498497.

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Zhang, Haipeng, Danielle Barmore, and Sangjin Ryu. "Flow Characterization of Microfluidic Paper-Based Analytical Devices With Hollow Channels." In ASME-JSME-KSME 2019 8th Joint Fluids Engineering Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/ajkfluids2019-5502.

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Анотація:
Abstract Microfluidic paper-based analytical devices (μPADs) are cost-effective point-of-care diagnostic devices. μPADs consist of porous filter paper patterned with hydrophobic solid ink barriers to create flow channels. Because a liquid sample flows through the paper channel driven by capillary force, the resultant flow is usually slow. To overcome this limitation, a hollow channel can be added to a μPAD to increase the flow speed significantly. The liquid flow through the hollow channel is known to be driven by a pressure difference between the inlet and outlet of the device. Accordingly, theoretical models have been proposed to understand and predict flow characteristics of μPADs with hollow channels. The goal of this study is to experimentally characterize liquid flow through μPADs having a hollow channel, by investigating relationships among the travel distance of the liquid front through the μPADs, the applied pressure difference, and the dimension of the hollow channel. Thus, the outcome of this study would contribute to validating the theoretical models and enable better control of liquid sample flow in μPADs with hollow channels.
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Blume, Steffen O. P., Michael J. Schertzer, Ridha Ben Mrad, and Pierre E. Sullivan. "Analytical Models to Determine the Electric Field Characteristics of a Multi-Electrode Impedimetric Immunosensor in a Digital Microfluidic Device." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-37571.

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Анотація:
The level of integration of digital microfluidics is continually increasing to include the system path from fluid manipulation and transport, on to reagent preparation, and finally reaction detection. Digital microfluidics therefore has the capability to encompass all steps of common biochemical protocols. Reported here is a set of analytical models for the design of a coplanar interdigitated multi-electrode array to be used as an impedimetric immunosensor in a digital microfluidic device for on-chip chemical reaction detection. The models are based on conformal mapping techniques, and are compared to results obtained from finite element analysis to discuss limitations of the model. The analytical models are feasible and inexpensive surrogates for numerical simulation methods.
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McCracken, Katherine E., Trinny Tat, Veronica Paz, Kelly A. Reynolds, and Jeong-Yeol Yoon. "Immunoagglutinated particle rheology sensing on a microfluidic paper-based analytical device for pathogen detection." In 2017 Spokane, Washington July 16 - July 19, 2017. St. Joseph, MI: American Society of Agricultural and Biological Engineers, 2017. http://dx.doi.org/10.13031/aim.201701190.

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Luo, L., J. Qi, L. Zhang, D. Deng, and Y. Li. "P1DH.2 - Paper-Based Microfluidic Analytical Device Based on Molecularly Imprinted Polymer for Detection of Carcinoembryonic Antigen." In 17th International Meeting on Chemical Sensors - IMCS 2018. AMA Service GmbH, Von-Münchhausen-Str. 49, 31515 Wunstorf, Germany, 2018. http://dx.doi.org/10.5162/imcs2018/p1dh.2.

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Zamri, N. L., та M. H. M. Salleh. "Investigation of liquid flow interaction on wax and cut channel paper-based microfluidic analytical device (μPAD)". У 7th Brunei International Conference on Engineering and Technology 2018 (BICET 2018). Institution of Engineering and Technology, 2018. http://dx.doi.org/10.1049/cp.2018.1569.

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Cai, Tianyu, Sixuan Duan, Hao Fu, Jia Zhu, Eng Gee Lim, Kaizhu Huang, Kai Hoettges, Xinyu Liu, and Pengfei Song. "A Paper-Based Microfluidic Analytical Device with A Highly Integrated On-Chip Valve For Autonomous ELISA." In 2022 IEEE 35th International Conference on Micro Electro Mechanical Systems Conference (MEMS). IEEE, 2022. http://dx.doi.org/10.1109/mems51670.2022.9699652.

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Moon, Hyejin, Praveen Kunchala, Yasith Nanayakkara, and Daniel W. Armstrong. "Liquid-Liquid Extraction Based on Digital Microfluidics." In ASME 2009 7th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2009. http://dx.doi.org/10.1115/icnmm2009-82268.

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Анотація:
Liquid-liquid extraction techniques are one of the major tools in chemical engineering, analytical chemistry, and biology, especially in a system where two immiscible liquids have an interface solutes exchange between the two liquid phases along the interface up to a point where the concentration ratios in the two liquids reach their equilibrium values [1]. In this paper, we propose to use room temperature ionic liquid (RTIL) as a second liquid phase for extraction, which forms immiscible interface with aqueous solutions. We demonstrate liquid-liquid extraction with the EWOD digital microfluidic device, two model extraction systems were tested. One is organic dye extracted from RTIL(1-butyl-3-methylimidazolium bis(trifluoromethanesulfonylimide or BMIMNTf2) to water and the other is iodine (I2) extracted from water to BMIMNTf2. Droplets of aqueous solution and BMIMNTf2 solution were generated on chip reservoir then transported for extraction and separated by EWOD actuation successfully.
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Rahman, M. Shafiqur, and Uttam K. Chakravarty. "Characterizations of the Paper-Based Microfluidic Devices Used for Detecting Fentanyl and Related Synthetic Opioids." In ASME 2019 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/imece2019-11581.

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Анотація:
Abstract The design and analysis of a paper-based microfluidic analytical device (μPAD) are presented in this paper for the detection of fentanyl and related synthetic opioids. Fentanyl, a synthetic opioid, is an extremely fast-acting synthetic narcotic analgesic having a high potency of approximately 100 to 200 times that of morphine. Detection of fentanyl can be done by colorimetric assays, i.e., spot tests with paper strips and μPADs which offer speed, simplicity of operation, portability, and affordability. The microfluidic behavior of liquid specimen and paper in the μPADs and test strips play a significant role in drug detection methods. Therefore, the study contains the fabrication of the test device using 3D printing and analysis of microfluidic behavior of the paper-based fentanyl test device. A multiphase computational fluid dynamics (CFD) model of a 3D microchannel is developed to evaluate the microfluidic properties. The CFD model incorporates the properties of cellulose and fentanyl solution to determine the flow parameters using the volume of fluid method. Wicking in the cellulose paper is studied analytically considering the Lucas-Washburn equation and Darcy’s law. Experiments with the fabricated μPAD and commercial test-kit samples are also conducted to compare the experimental results with the results for the flow parameters found from the numerical simulation.
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Yuwono, Rio Akbar, Mokhammad Fahmi Izdiharruddin, and Ruri Agung Wahyuono. "Integrated ZnO nanoparticles on paper-based microfluidic: toward efficient analytical device for glucose detection based on impedance and FTIR measurement." In Second International Seminar on Photonics, Optics, and Its Applications (ISPhOA 2016), edited by Agus M. Hatta and Aulia M. T. Nasution. SPIE, 2016. http://dx.doi.org/10.1117/12.2243827.

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