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Автор: Grafiati

Опубліковано: 29 лютого 2024

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1

Wang, Lingtian, Dajun Jiang, Qiyang Wang, Qing Wang, Haoran Hu, and Weitao Jia. "The Application of Microfluidic Techniques on Tissue Engineering in Orthopaedics." Current Pharmaceutical Design 24, no. 45 (April 16, 2019): 5397–406. http://dx.doi.org/10.2174/1381612825666190301142833.

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Background: Tissue engineering (TE) is a promising solution for orthopaedic diseases such as bone or cartilage defects and bone metastasis. Cell culture in vitro and scaffold fabrication are two main parts of TE, but these two methods both have their own limitations. The static cell culture medium is unable to achieve multiple cell incubation or offer an optimal microenvironment for cells, while regularly arranged structures are unavailable in traditional cell-laden scaffolds, which results in low biocompatibility. To solve these problems, microfluidic techniques are combined with TE. By providing 3-D networks and interstitial fluid flows, microfluidic platforms manage to maintain phenotype and viability of osteocytic or chondrocytic cells, and the precise manipulation of liquid, gel and air flows in microfluidic devices leads to the highly organized construction of scaffolds. Methods: In this review, we focus on the recent advances of microfluidic techniques applied in the field of tissue engineering, especially in orthropaedics. An extensive literature search was done using PubMed. The introduction describes the properties of microfluidics and how it exploits the advantages to the full in the aspects of TE. Then we discuss the application of microfluidics on the cultivation of osteocytic cells and chondrocytes, and other extended researches carried out on this platform. The following section focuses on the fabrication of highly organized scaffolds and other biomaterials produced by microfluidic devices. Finally, the incubation and studying of bone metastasis models in microfluidic platforms are discussed. Conclusion: The combination of microfluidics and tissue engineering shows great potentials in the osteocytic cell culture and scaffold fabrication. Though there are several problems that still require further exploration, the future of microfluidics in TE is promising.

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2

Naher, Sumsun, Dylan Orpen, Dermot Brabazon, and Muhammad M. Morshed. "An Overview of Microfluidic Mixing Application." Advanced Materials Research 83-86 (December 2009): 931–39. http://dx.doi.org/10.4028/www.scientific.net/amr.83-86.931.

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Microfluidics is a technology where application span the biomedical field and beyond. Single cell analysis, tissue engineering, capillary electrophoresis, cancer detection, and immunoassays are just some of the applications within the medical field where microfluidics have excelled. The development of microfluidic technology has lead to novel research into fuel cells, ink jet printing, microreactors and electronic component cooling areas as diverse as food, pharmaceutics, cosmetics, medicine and biotechnology have benefited from these developments. Since laminar flow is prevailing at most flow regimes in the micro-scale, thorough mixing is a challenge within microfluidics. Therefore, understanding the flow fields on the micro-scale is key to the development of methods for successfully microfluidic mixing applications.

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3

Goel, Sanket, Lanka Tata Rao, Prakash Rewatkar, Haroon Khan, Satish Kumar Dubey, Arshad Javed, Gyu Man Kim, and Sanket Goel. "Single microfluidic fuel cell with three fuels – formic acid, glucose and microbes: A comparative performance investigation." Journal of Electrochemical Science and Engineering 11, no. 4 (October 5, 2021): 306–16. http://dx.doi.org/10.5599/jese.1092.

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The development of microfluidic and nanofluidic devices is gaining remarkable attention due to the emphasis put on miniaturization of conventional energy conversion and storage processes. A microfluidic fuel cell can integrate flow of electrolytes, electrode-electrolyte interactions, and power generation in a microfluidic channel. Such microfluidic fuel cells can be categorized on the basis of electrolytes and catalysts used for power generation. In this work, for the first time, a single microfluidic fuel cell was harnessed by using different fuels like glucose, microbes and formic acid. Herein, multi-walled carbon nanotubes (MWCNT) acted as electrode material, and performance investigations were carried out separately on the same microfluidic device for three different types of fuel cells (formic acid, microbial and enzymatic). The fabricated miniaturized microfluidic device was successfully used to harvest energy in microwatts from formic acid, microbes and glucose, without any metallic catalyst. The developed microfluidic fuel cells can maintain stable open-circuit voltage, which can be used for energizing various low-power portable devices or applications.

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4

Goel, Sanket, Lanka Tata Rao, Prakash Rewatkar, Haroon Khan, Satish Kumar Dubey, Arshad Javed, Gyu Man Kim, and Sanket Goel. "Single microfluidic fuel cell with three fuels – formic acid, glucose and microbes: A comparative performance investigation." Journal of Electrochemical Science and Engineering 11, no. 4 (October 5, 2021): 306–16. http://dx.doi.org/10.5599/jese.1092.

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Анотація:

The development of microfluidic and nanofluidic devices is gaining remarkable attention due to the emphasis put on miniaturization of conventional energy conversion and storage processes. A microfluidic fuel cell can integrate flow of electrolytes, electrode-electrolyte interactions, and power generation in a microfluidic channel. Such microfluidic fuel cells can be categorized on the basis of electrolytes and catalysts used for power generation. In this work, for the first time, a single microfluidic fuel cell was harnessed by using different fuels like glucose, microbes and formic acid. Herein, multi-walled carbon nanotubes (MWCNT) acted as electrode material, and performance investigations were carried out separately on the same microfluidic device for three different types of fuel cells (formic acid, microbial and enzymatic). The fabricated miniaturized microfluidic device was successfully used to harvest energy in microwatts from formic acid, microbes and glucose, without any metallic catalyst. The developed microfluidic fuel cells can maintain stable open-circuit voltage, which can be used for energizing various low-power portable devices or applications.

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5

Guima, Katia-Emiko, Pedro-Henrique L. Coelho, Magno A. G. Trindade, and Cauê Alves Martins. "3D-Printed glycerol microfluidic fuel cell." Lab on a Chip 20, no. 12 (2020): 2057–61. http://dx.doi.org/10.1039/d0lc00351d.

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6

Kamitani, Ai, Satoshi Morishita, Hiroshi Kotaki, and Steve Arscott. "Microfabricated microfluidic fuel cells." Sensors and Actuators B: Chemical 154, no. 2 (June 2011): 174–80. http://dx.doi.org/10.1016/j.snb.2009.11.014.

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7

Wang, Yifei, Shijing Luo, Holly Y. H. Kwok, Wending Pan, Yingguang Zhang, Xiaolong Zhao, and Dennis Y. C. Leung. "Microfluidic fuel cells with different types of fuels: A prospective review." Renewable and Sustainable Energy Reviews 141 (May 2021): 110806. http://dx.doi.org/10.1016/j.rser.2021.110806.

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8

Mousavi Shaegh, Seyed Ali, Nam-Trung Nguyen, and Siew Hwa Chan. "Air-breathing microfluidic fuel cell with fuel reservoir." Journal of Power Sources 209 (July 2012): 312–17. http://dx.doi.org/10.1016/j.jpowsour.2012.02.115.

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9

Phirani, J., and S. Basu. "Analyses of fuel utilization in microfluidic fuel cell." Journal of Power Sources 175, no. 1 (January 2008): 261–65. http://dx.doi.org/10.1016/j.jpowsour.2007.08.099.

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10

Feali, M. S. "Transient Response of Microfluidic Fuel Cell." Russian Journal of Electrochemistry 56, no. 5 (May 2020): 437–46. http://dx.doi.org/10.1134/s1023193520030040.

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11

Salloum, Kamil S., and Jonathan D. Posner. "Counter flow membraneless microfluidic fuel cell." Journal of Power Sources 195, no. 19 (October 2010): 6941–44. http://dx.doi.org/10.1016/j.jpowsour.2010.03.096.

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12

Salloum, Kamil S., and Jonathan D. Posner. "A membraneless microfluidic fuel cell stack." Journal of Power Sources 196, no. 3 (February 2011): 1229–34. http://dx.doi.org/10.1016/j.jpowsour.2010.08.069.

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13

Herlambang, Yusuf Dewantoro, Kurnianingsih, Anis Roihatin, Totok Prasetyo, Marliyati, Taufik, and Jin-Cherng Shyu. "A Numerical Study of Bubble Blockage in Microfluidic Fuel Cells." Processes 10, no. 5 (May 6, 2022): 922. http://dx.doi.org/10.3390/pr10050922.

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Based on fuel crossover behavior and bubble nucleation in the microfluidic fuel cell’s channel, this research numerically presents the performance of air-breathing direct formic acid microfluidic fuel cells. In the simulation, a three-dimensional microfluidic fuel cell model was used. The continuity, momentum, species transport, and charge equations were used to develop the model transport behavior, whereas the Brinkman equation represented the porous medium flow in the gas diffusion layer. The I–V and power density curves are generated using the Butler–Volmer equation. The simulation and current experimental data were compared under identical operating conditions to validate the I–V curve of the microfluidic fuel cell model. The model was used to investigate the current density distribution in the microchannel due to bubble obstruction and the reactant concentration on both electrodes. Fuel crossover resulted in a large decrease in open-circuit voltage and a reduction in fuel concentration above the anode electrode. The findings also showed that a low-flow rate air-breathing direct formic acid microfluidic fuel cell is more prone to CO2 bubble formation.

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14

Kjeang, Erik, Ned Djilali, and David Sinton. "Microfluidic fuel cells: A review." Journal of Power Sources 186, no. 2 (January 2009): 353–69. http://dx.doi.org/10.1016/j.jpowsour.2008.10.011.

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15

Feali, Mohammad Saeed, and Morteza Fathipour. "Multi-objective optimization of microfluidic fuel cell." Russian Journal of Electrochemistry 50, no. 6 (June 2014): 561–68. http://dx.doi.org/10.1134/s1023193514060044.

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16

Choban, E. "Microfluidic fuel cell based on laminar flow." Journal of Power Sources 128, no. 1 (March 29, 2004): 54–60. http://dx.doi.org/10.1016/j.jpowsour.2003.11.052.

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17

Kjeang, Erik, Brenton T. Proctor, Alexandre G. Brolo, David A. Harrington, Ned Djilali, and David Sinton. "High-performance microfluidic vanadium redox fuel cell." Electrochimica Acta 52, no. 15 (April 2007): 4942–46. http://dx.doi.org/10.1016/j.electacta.2007.01.062.

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18

Safdar, M., J. Jänis, and S. Sánchez. "Microfluidic fuel cells for energy generation." Lab on a Chip 16, no. 15 (2016): 2754–58. http://dx.doi.org/10.1039/c6lc90070d.

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19

Priya, M., A. Arun, M. Elumalai, S. Kiruthika, and B. Muthukumaran. "A Development of Ethanol/Percarbonate Membraneless Fuel Cell." Advances in Physical Chemistry 2014 (May 29, 2014): 1–8. http://dx.doi.org/10.1155/2014/862691.

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The electrocatalytic oxidation of ethanol on membraneless sodium percarbonate fuel cell using platinum electrodes in alkaline-acidic media is investigated. In this cell, ethanol is used as the fuel and sodium percarbonate is used as an oxidant for the first time in an alkaline-acidic media. Sodium percarbonate generates hydrogen peroxide in aqueous medium. At room temperature, the laminar-flow-based microfluidic membraneless fuel cell can reach a maximum power density of 18.96 mW cm−2 with a fuel mixture flow rate of 0.3 mL min−2. The developed fuel cell features no proton exchange membrane. The simple planar structured membraneless ethanol fuel cell presents with high design flexibility and enables easy integration of the microscale fuel cell into actual microfluidic systems and portable power applications.

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20

Elumalai, M., M. Raja, A. Rajasekaran, and B. Chinnaraja. "Analysis of Membranless Formic Acid Fuel Cell using E-Shaped Microfluidic Channel." Asian Journal of Chemistry 31, no. 11 (September 28, 2019): 2497–502. http://dx.doi.org/10.14233/ajchem.2019.22175.

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A microfluidic fuel cell has been fabricated using formic acid in an alkaline media as the fuel and sodium percarbonate in acidic media as the oxidant. Various operating conditions and different cell dimensions were applied to evaluate the fuel cell performance. The laminar flow-based membraneless fuel cell was found to reach a maximum power density of 23.60 mW cm-2 using 1.50 M HCOOH in 3 M NaOH solution as the fuel and 0.15 M percarbonate in 1.50 M H2SO4 solution as the oxidant at room temperature. The fuel cell system has no proton exchange membrane. This simple membraneless fuel cell with a planar structure has a high design flexibility, which enables its easy integration into actual microfluidic systems and miniature power applications.

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21

Zhang, Hao, Hong Xu, Li Zhang, Dennis Y. C. Leung, Huizhi Wang, and Jin Xuan. "A Counter-flow Microfluidic Fuel Cell Achieving Concentrated Fuel Operation." Energy Procedia 75 (August 2015): 1990–95. http://dx.doi.org/10.1016/j.egypro.2015.07.251.

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22

Smith, Suzanne, Phophi Madzivhandila, René Sewart, Ureshnie Govender, Holger Becker, Pieter Roux, and Kevin Land. "Microfluidic Cartridges for Automated, Point-of-Care Blood Cell Counting." SLAS TECHNOLOGY: Translating Life Sciences Innovation 22, no. 2 (November 19, 2016): 176–85. http://dx.doi.org/10.1177/2211068216677820.

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Disposable, low-cost microfluidic cartridges for automated blood cell counting applications are presented in this article. The need for point-of-care medical diagnostic tools is evident, particularly in low-resource and rural settings, and a full blood count is often the first step in patient diagnosis. Total white and red blood cell counts have been implemented toward a full blood count, using microfluidic cartridges with automated sample introduction and processing steps for visual microscopy cell counting to be performed. The functional steps within the microfluidic cartridge as well as the surrounding instrumentation required to control and test the cartridges in an automated fashion are described. The results recorded from 10 white blood cell and 10 red blood cell counting cartridges are presented and compare well with the results obtained from the accepted gold-standard flow cytometry method performed at pathology laboratories. Comparisons were also made using manual methods of blood cell counting using a hemocytometer, as well as a commercially available point-of-care white blood cell counting system. The functionality of the blood cell counting microfluidic cartridges can be extended to platelet counting and potential hemoglobin analysis, toward the implementation of an automated, point-of-care full blood count.

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23

Jayashree, Ranga S., Lajos Gancs, Eric R. Choban, Alex Primak, Dilip Natarajan, Larry J. Markoski, and Paul J. A. Kenis. "Air-Breathing Laminar Flow-Based Microfluidic Fuel Cell." Journal of the American Chemical Society 127, no. 48 (December 2005): 16758–59. http://dx.doi.org/10.1021/ja054599k.

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24

Jayashree, Ranga S., Michael Mitchell, Dilip Natarajan, Larry J. Markoski, and Paul J. A. Kenis. "Microfluidic Hydrogen Fuel Cell with a Liquid Electrolyte." Langmuir 23, no. 13 (June 2007): 6871–74. http://dx.doi.org/10.1021/la063673p.

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25

Lee, D. W., I. Doh, Y. Kim, and Y. H. Cho. "Advanced combinational microfluidic multiplexer for fuel cell reactors." Journal of Physics: Conference Series 476 (December 4, 2013): 012045. http://dx.doi.org/10.1088/1742-6596/476/1/012045.

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26

Chino, Isabel, Omar Muneeb, Emily Do, Vy Ho, and John L. Haan. "A paper microfluidic fuel cell powered by urea." Journal of Power Sources 396 (August 2018): 710–14. http://dx.doi.org/10.1016/j.jpowsour.2018.06.082.

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27

Zhang, Hao, Michael K. H. Leung, Jin Xuan, Hong Xu, Li Zhang, Dennis Y. C. Leung, and Huizhi Wang. "Energy and exergy analysis of microfluidic fuel cell." International Journal of Hydrogen Energy 38, no. 15 (May 2013): 6526–36. http://dx.doi.org/10.1016/j.ijhydene.2013.03.046.

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28

Escalona-Villalpando, R. A., A. Dector, D. Dector, A. Moreno-Zuria, S. M. Durón-Torres, M. Galván-Valencia, L. G. Arriaga, and J. Ledesma-García. "Glucose microfluidic fuel cell using air as oxidant." International Journal of Hydrogen Energy 41, no. 48 (December 2016): 23394–400. http://dx.doi.org/10.1016/j.ijhydene.2016.04.238.

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29

Copenhaver, Thomas S., Krutarth H. Purohit, Kryls Domalaon, Linda Pham, Brianna J. Burgess, Natalie Manorothkul, Vicente Galvan, Samantha Sotez, Frank A. Gomez, and John L. Haan. "A microfluidic direct formate fuel cell on paper." ELECTROPHORESIS 36, no. 16 (March 12, 2015): 1825–29. http://dx.doi.org/10.1002/elps.201400554.

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30

Li, Li, Lei Ling, Yajun Xie, Shuai Shan, Shaoyi Bei, Keqing Zheng, and Qiang Xu. "Counter-flow microfluidic fuel cell with trapezoidal electrodes." Sustainable Energy Technologies and Assessments 56 (March 2023): 103005. http://dx.doi.org/10.1016/j.seta.2022.103005.

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31

Gowdhamamoorthi, M., A. Arun, S. Kiruthika, and B. Muthukumaran. "Enhanced Performance of Membraneless Sodium Percarbonate Fuel Cells." Journal of Materials 2013 (May 22, 2013): 1–7. http://dx.doi.org/10.1155/2013/548026.

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This paper presents the continuous flow operation of membraneless sodium percarbonate fuel cell (MLSPCFC) using acid/alkaline bipolar electrolyte. In the acid/alkaline bipolar electrolyte, percarbonate works both as an oxidant as well as reductant. Sodium percarbonate affords hydrogen peroxide in aqueous medium. The cell converts the energy released by H2O2 decomposition with H+ and OH− ions into electricity and produces water and oxygen. At room temperature, the laminar flow based microfluidic membraneless fuel cell can reach a maximum power density of 28 mW/cm2 with the molar ratio of [Percarbonate]/[NaOH] = 1 as fuel and [Percarbonate]/[H2SO4] = 2 as oxidant. The paper reports for the first time the use of sodium percarbonate as the oxidant and reductant. The developed fuel cell emits no CO2 and features no proton exchange membrane, inexpensive catalysts, and simple planar structure, which enables high design flexibility and easy integration of the microscale fuel cell into actual microfluidic systems and portable power applications.

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32

Liu, Hongyan. "Review on Microfluidic Technology Based Synthesis of Fe-based Nanoparticles for Catalyst in Fuel Cell." Academic Journal of Science and Technology 7, no. 2 (September 27, 2023): 98–100. http://dx.doi.org/10.54097/ajst.v7i2.11950.

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Conventional combustion based energy generations, reliant on fossil fuels, poses significant environmental harm. In contrast, fuel cells offer an efficient and eco-friendly energy conversion method, capable of integrating with renewable sources and contemporary energy carriers to support sustainable development and energy security. Consequently, fuel cells are considered the promising energy conversion devices of the future. However, extensive research reveals that the cost of catalysts constitutes the most substantial portion of the overall fuel cell cost. To tackle this cost constraint, considerable advancements have been achieved in the development of cost-effective, precious metal-free electrocatalysts. Common methods for the preparation of metal nanomaterials (NPs) have more stringent requirements, lower deposition efficiency and higher costs. In addition, conventional preparation methods without precisely control of reagent concentration, mixing and temperature during the preparation process, makes it difficult to obtain the same results with poor reproducibility, restricting the industrial fabrication of high performance nanomaterials. Microfluidic reactors have advantages of efficient mixing, high heat and mass transfer, low reagent consumption, precise control of reactant components, residence time, reaction temperature and other parameters. They can also be coupled with multi-step reactions, greatly reducing the preparation time while obtaining composite nanomaterials with excellent dimensional homogeneity. In this review, we mainly discuss the microfluidic technology-based synthesis of PGM-free catalyst used in fuel cell.

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33

Kwok, Y. H., Y. Wang, M. Wu, F. Li, Y. Zhang, H. Zhang, and D. Y. C. Leung. "A dual fuel microfluidic fuel cell utilizing solar energy and methanol." Journal of Power Sources 409 (January 2019): 58–65. http://dx.doi.org/10.1016/j.jpowsour.2018.10.095.

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34

Smaluch, Katharina, Christian Dusny, Dietrich Kohlheyer, and Alexander Grünberger. "Mikroskalige Massenbilanzierung in mikrofluidischen Umgebungen." BIOspektrum 29, no. 5 (September 2023): 534–35. http://dx.doi.org/10.1007/s12268-023-1978-8.

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AbstractImplementing key biochemical engineering principles based on the kinetics and stoichiometry of growth unlocks the full potential of microfluidic single-cell analysis. We introduce a unique integrative approach, using non-invasive advanced microfluidic cultivation and analysis technologies to integrate physiologic single-cell data. Our groundwork enables microscale material balancing beyond population-based average values and advances modern bioprocess modeling [1].

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35

Feali, M. S. "Y-Shaped Microfluidic Fuel Cell with Novel Cathode Structure." Russian Journal of Electrochemistry 58, no. 7 (July 2022): 626–33. http://dx.doi.org/10.1134/s1023193522070060.

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36

Kjeang, Erik, Raphaelle Michel, David A. Harrington, Ned Djilali, and David Sinton. "A Microfluidic Fuel Cell with Flow-Through Porous Electrodes." Journal of the American Chemical Society 130, no. 12 (March 2008): 4000–4006. http://dx.doi.org/10.1021/ja078248c.

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37

Salloum, Kamil S., Joel R. Hayes, Cody Friesen, and Jonathan D. Posner. "Sequential Flow Membraneless Microfluidic Fuel Cell with Porous Electrodes." ECS Transactions 13, no. 25 (December 18, 2019): 21–38. http://dx.doi.org/10.1149/1.3007996.

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38

Moore, Sean, David Sinton, and David Erickson. "A plate-frame flow-through microfluidic fuel cell stack." Journal of Power Sources 196, no. 22 (November 2011): 9481–87. http://dx.doi.org/10.1016/j.jpowsour.2011.07.024.

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39

Salloum, Kamil S., Joel R. Hayes, Cody A. Friesen, and Jonathan D. Posner. "Sequential flow membraneless microfluidic fuel cell with porous electrodes." Journal of Power Sources 180, no. 1 (May 2008): 243–52. http://dx.doi.org/10.1016/j.jpowsour.2007.12.116.

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40

Wang, Yifei, and Dennis Y. C. Leung. "A high-performance aluminum-feed microfluidic fuel cell stack." Journal of Power Sources 336 (December 2016): 427–36. http://dx.doi.org/10.1016/j.jpowsour.2016.11.009.

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41

Olivares-Ramírez, J. M., V. M. Ovando-Medina, A. Ortíz-Verdín, D. M. Amaya-Cruz, J. Coronel-Hernandez, A. Marroquín, and A. Dector. "Lateral flow assay HIV-based microfluidic blood fuel cell." Journal of Physics: Conference Series 1119 (November 2018): 012022. http://dx.doi.org/10.1088/1742-6596/1119/1/012022.

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42

Rao, Lanka Tata, Satish Kumar Dubey, Arshad Javed, and Sanket Goel. "Development of Membraneless Paper‐pencil Microfluidic Hydrazine Fuel Cell." Electroanalysis 32, no. 11 (October 20, 2020): 2581–88. http://dx.doi.org/10.1002/elan.202060191.

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