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1
Мартиненко, Олександр Вікторович, Людмила Миколаївна Бондаренко, Олександр Карпович Міхєєнко та Ганна Володиміровна Ткачук. "Дослідження впливу різних силових чинників на напружено-деформований стан елементів гідропередачі". Thesis, НТУ "ХПІ", 2011. http://repository.kpi.kharkov.ua/handle/KhPI-Press/14751.
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Мартиненко, Олександр Вікторович, Ганна Володиміровна Ткачук та Антон Миколайович Ткачук. "Аналіз термопружної контактної взаємодії втулки з циліндром гідрооб'ємної передачі". Thesis, НТУ "ХПІ", 2010. http://repository.kpi.kharkov.ua/handle/KhPI-Press/14753.
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佐藤, 一雄, 和雄 浅海, 元. 小林, 康郎 入江 та 光宏 式田. "結晶異方性エッチング解析システムMICROCADの開発(<小特集>マイクロマシン関連技術)". 電子情報通信学会, 1999. http://hdl.handle.net/2237/12659.
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4
Gutzwiller, Sarah C. "Adaptation and Exaptation in the Evolution of the Upper Molar Talon in Microbats (Suborder Microchiroptera)." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1439458685.
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5
O'Brien, Graham James. "Molecular analysis of microcin 24 : Genetics, secretion and mode of action of a novel microcin." Thesis, University of Canterbury. Plant and Microbial Sciences, 1996. http://hdl.handle.net/10092/6808.
Повний текст джерелаАнотація:
Colicins and microcins are proteinaceous antimicrobial agents produced by members of the Enterobacteriaceae which are active against other members of this family. Colicin24 is a novel bacteriocin produced by a uropathogenic strain of Escherichia coli isolated at Christchurch Hospital. Through detailed genetic analysis of the DNA encoding this toxin and assaying the toxic activity, colicin 24 was re-classified as microcin 24 and has been shown to have a similar genetic organisation to that of colicin V and a novel mode of activity.
The region of DNA encoding microcin 24 was subcloned from pGOB34 into pBR322 generating pGOB18 (5.44kb). Mutagenesis, DNA sequencing and transcomplementation identified two regions with high sequence similarity and functional homology to the ColV transporters CvaA and CvaB. The insert DNA of pGOB18 was sequenced in both directions and has been found to contain 5267bp encoding five open reading frames, mdbA, mtft, mtfS, mtfA and mtfB, forming three operons mdbA, mtfI/mtfS and mtfA/mtfB all of which were transcribed in the same direction. The predicted protein products of all the open reading frames except mtfB were confirmed by expressing the genes in minicells. Further mutagenesis and trans-complementation has identified mdbA as a cis acting positive regulatory gene with sequence similarity to the histone-like proteins. The mtfI and mtfS genes were confirmed as the Mcc24 immunity gene and the Mcc24 structural gene respectively. The genes mtfA and mtfB were found to encode the transport proteins homologous to CvaA and CvaB respectively, with mtfB encoding a protein which is a member of the ABC family of bacterial transporters. Transport also requires the TolC outer membrane protein. Analysis of the mtfS DNA sequence has identified a double glycine leader sequence, making MtfS the second microcin after ColV to belong to this class of peptide antibiotics. Experimental evidence suggested that unlike ColV, Mcc24 is inactive within the producing cell, however both toxins require the ABC transporter for post-translational modification of the pre-peptide.
The regulation of Mcc24 synthesis is controlled by the interaction between σs, Fur, and MdbA, encoded by the mdbA gene. Analysis of the promoter sequences has identified putative regions of DNA bending which might facilitate the binding of σs and MdbA. A Fur-box with good sequence similarity to the consensus Fur-box has been identified in the mtfI/mtfS promoter and is the proposed site for Fur binding.
The activity spectrum of Mcc24 is restricted to enteric bacteria and SernA, the MccE492 receptor, is also required as the receptor for Mcc24. Extracts of Mcc24 have been found to degrade both linearised and covalently closed circular DNA in vitro. The activity is absent in extracts from mtfS - strains, suggesting that Mcc24 inhibits the growth of sensitive cells by degrading DNA. The effect of Mcc24 expression on the virulence of E. coli was tested using the embryo lethality assay, however unlike ColV which increases the virulence of strains, the expression of Mcc24 did not appear to have a significant effect on E. coli virulence in this system.
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Trenz, Cornelius Günter. "Klinische Evaluierung der Validität des nichtinvasiven Kapnometrie-Systems Microcap Plus." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-60085.
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Jaskot, Roger Dean, and Harold W. Henry. "MICROLAN file transfer program for microprocessors." Thesis, Monterey, California. Naval Postgraduate School, 1985. http://hdl.handle.net/10945/23451.
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Rajantie, Hanna Katarina. "Electrochemical titrations with dual microband electrodes." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272111.
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THOMAS, JENNIFER HODGES. "APPLICATIONS OF MICROBEAD-BASED ELECTROCHEMICAL IMMUNOASSAY." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1069337644.
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Van, Buren Brian G. "Graphical microcode simulator with a reconfigurable datapath /." Online version of thesis, 2006. https://ritdml.rit.edu/dspace/handle/1850/2892.
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Gin, Karina Y. H. (Karina Yew Hoong). "Microbal size spectra from diverse marine ecosystems." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/40155.
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Pieri, Stefano <1977>. "Multi-objective optimization of microgas turbine recuperatos." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/415/.
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Quiroz, Marco Antonio. "Simulation of a microload automated storage/retrieval system." Thesis, Georgia Institute of Technology, 1986. http://hdl.handle.net/1853/24574.
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Torres, Jean-Marc. "Electrical breakdown at micrometre separations." Thesis, Heriot-Watt University, 2002. http://hdl.handle.net/10399/447.
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Küpper, Patrick. "Stereoselektive Totalsynthese verschiedener Cassia- und Microcos-Piperidinderivate Synthese des (-)-Cassins /." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=979464587.
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Curzon, Paul. "A structured approach to the verification of low level microcode." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335713.
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Wang, Yunmiao. "Microgap Structured Optical Sensor for Fast Label-free DNA Detection." Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/32875.
Повний текст джерелаАнотація:
DNA detection technology has developed rapidly due to its extensive application in clinical diagnostics, bioengineering, environmental monitoring, and food science areas. Currently developed methods such as surface Plasmon resonance (SPR) methods, fluorescent dye labeled methods and electrochemical methods, usually have the problems of bulky size, high equipment cost and time-consuming algorithms, so limiting their application for in vivo detection. In this work, an intrinsic Fabry-Perot interferometric (IFPI) based DNA sensor is presented with the intrinsic advantages of small size, low cost and corrosion-tolerance. This sensor has experimentally demonstrated its high sensitivity and selectivity.
In theory, DNA detection is realized by interrogating the sensorâ s optical cavity length variation resulting from hybridization event. First, a microgap structure based IFPI sensor is fabricated with simple etching and splicing technology. Subsequently, considering the sugar phosphate backbone of DNA, layer-by-layer electrostatic self-assembly technique is adopted to attach the single strand capture DNA to the sensor endface. When the target DNA strand binds to the single-stranded DNA successfully, the optical cavity length of sensor will be increased. Finally, by demodulating the sensor spectrum, DNA hybridization event can be judged qualitatively.
This sensor can realize DNA detection without attached label, which save the experiment expense and time. Also the hybridization detection is finished within a few minutes. This quick response feature makes it more attractive in diagnose application. Since the sensitivity and specificity are the most widely used statistics to describe a diagnostic test, so these characteristics are used to evaluate this biosensor. Experimental results demonstrate that this sensor has a sensitivity of 6nmol/ml and can identify a 2 bp mismatch. Since this sensor is optical fiber based, it has robust structure and small size ( 125μm ). If extra etching process is applied to the sensor, the size can be further reduced. This promises the sensor potential application of in-cell detection. Further investigation can be focused on the nanofabrication of this DNA sensor, and this is very meaningful topic not only for diagnostic test but also in many other applications such as food industry, environment monitoring.Master of Science
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Spilleir, Davi de Pinho. "Microcr?dito e economia solid?ria ? Aspectos sustent?veis." Pontif?cia Universidade Cat?lica de Campinas, 2018. http://tede.bibliotecadigital.puc-campinas.edu.br:8080/jspui/handle/tede/1191.
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Solidarity economy is an important way of production that seeks to promote solidarity, integration and synergy among its participants, who are owners and workers at the same time of these enterprises. However, due to several internal and external factors, these enterprises suffer to remain open and economically viable. The most severe and motivating factor of the greatest number of bankruptcies is the difficulty of obtaining credit. Given the relevance that survival has for all people participating in the solidarity economy, the objective of this work is to make a proactive contribution, identifying and validating elements that may be useful to projects of solidarity economy in relation to obtaining credit. For its accomplishment, as a methodology it is developed, starting from a bibliographical research, defined by periodicals and classic books of the themes, oriented by key words like solidarity economy, enterprise and credit, a research that allowed to find relevant elements, for the discussion in question. For the analysis of the identified elements a categorization was established in relation to the view of the actors involved, that is, the institutional vision, with external factors, and the user's view, with internal elements. The two visions eventually culminated in the elaboration of the propositional contribution. In order to validate such elements, it was followed in four different cases. As a result, it was concluded that the present work is useful for all those projects of solidarity economy that may eventually come up against credit problems.
A economia solid?ria ? uma importante maneira de produ??o que visa promover a solidariedade, integra??o e sinergia entre seus participantes, que s?o propriet?rios e trabalhadores ao mesmo tempo destes empreendimentos. Entretanto por diversos fatores tanto internos, como externos estes empreendimentos sofrem para se manterem abertos e economicamente vi?veis. O mais severo e que motiva o maior n?mero de fal?ncias ? a dificuldade de obten??o credit?cia. Tendo em vista a relev?ncia que a sobreviv?ncia tem para todas as pessoas que participam da economia solid?ria, o objetivo deste trabalho ? fazer uma contribui??o propositiva, identificando e validando elementos que possam ser ?teis a empreendimentos de economia solid?ria no que concerne ? obten??o de cr?dito. Para sua realiza??o, como metodologia desenvolve-se, a partir de uma pesquisa bibliogr?fica, definida por peri?dicos e livros cl?ssicos dos temas, orientada por palavras chaves como economia solid?ria, empreendimento e cr?dito, uma pesquisa que permitiu encontrar elementos relevantes, para a discuss?o em quest?o. Para a an?lise dos elementos identificados foi estabelecida uma categoriza??o em rela??o ? vis?o dos atores envolvidos, ou seja, a vis?o institucional, com fatores externos, e a vis?o de usu?rio, com elementos internos. As duas vis?es acabaram por culminar, finalmente, na elabora??o da contribui??o propositiva. A fim de se validar tais elementos, seguiu-se com a sua aplica??o em quatro casos distintos. Como resultado chegou-se a conclus?o de que o presente trabalho se apresenta como ?til para todos aqueles empreendimentos de economia solid?ria que venham eventualmente a se deparar com problemas credit?cios.
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Papajová, Gabriela. "Obrazové detektory rentgenového záření pro aplikace v microCT systémech." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-316801.
Повний текст джерелаАнотація:
Diplomová práce se zabývá detektory rentgenového záření pro mikro-CT systémy. Teoretická část zahrnuje standartní typy rentgenových detektorů a požadavky na kvalitu obrazu pro výslednou 3D rekonstrukci. V závěru jsou popsány fyzikální parametry reálných detektorů a metody jejich měření a vyhodnocení.
20
Bartrina-Rapesta, Joan, Francesc Aulí-Llinàs, Ian Blanes, Michael W. Marcellin, Victor Sanchez, and Joan Serra-Sagristà. "Efficient storage of microCT data preserving bone morphometry assessment." PERGAMON-ELSEVIER SCIENCE LTD, 2016. http://hdl.handle.net/10150/621509.
Повний текст джерелаАнотація:
Preclinical micro-computed tomography (microCT) images are of utility for 3D morphological bone evaluation, which is of great interest in cancer detection and treatment development. This work introduces a compression strategy for microCTs that allocates specific substances in different Volumes of Interest (Vols). The allocation procedure is conducted by the Hounsfield scale. The Vols are coded independently and then grouped in a single DICOM-compliant file. The proposed method permits the use of different codecs, identifies and transmit data corresponding to a particular substance in the compressed domain without decoding the volume(s), and allows the computation of the 3D morphometry without needing to store or transmit the whole image. The proposed approach reduces the transmitted data in more than 90% when the 3D morphometry evaluation is performed in high density and low density bone. This work can be easily extended to other imaging modalities and applications that work with the Hounsfield scale. (C) 2015 Elsevier Ltd. All rights reserved.
21
Maruyama, Hisataka, Fumihito Arai, Toshio Fukuda, and 敏男 福田. "Fabrication of Functional Gel-Microbead for Local Environment Measurement in Microchip." IEEE, 2008. http://hdl.handle.net/2237/11147.
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22
Vionnet, Carlos Alberto. "Analysis of lubricant flows within the microgap of rotary lip seals." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186465.
Повний текст джерелаАнотація:
The study of a thin, incompressible Newtonian fluid layer trapped between two almost parallel, sliding surfaces has been actively pursued in the last decades. This subject includes lubrication applications such as slider bearings or the sealing of non-pressurized fluids with rotary lip seals. When a viscous lubricant flows between an elastic body and a rigid surface, the contact geometry may undergo substantial deformation affecting the flow field of the lubricant. Therefore, a coupled model between an elastic ring and the fluid film underneath it is proposed. Initially, a linear stability analysis is performed. Then, non-linear calculations are presented showing that the system deformations are able to induce mixing of lubricant throughout the sealed region. In the second part of this work, the flow of lubricant fluid through the micro-gap of rotary lip seals is analyzed theoretically and numerically from a different perspective. The study is carried out assuming that a 'small-gap' parameter δ attains an extreme value in the Navier-Stokes equations. The precise meaning of small-gap is achieved by the limit δ = 0, and the numerical solution of the resulting set of equations predicts transport of lubricant through the contact region due to centrifugal instabilities. Numerical results obtained with the finite element method are presented. In particular, the influence of inflow and outflow boundary conditions, and their importance in the simulated flow are discussed. To this aim, the penalty method for incompressible flows in presence of variable body forces is re-examined with the help of well-known examples, yielding a corrected formulation that is more accurate and faster than standard finite element methods found in the literature.
23
Collin, Frederic. "Fragments of microcin B17 as a source of new topoisomerase inhibitors." Thesis, University of East Anglia, 2010. https://ueaeprints.uea.ac.uk/35074/.
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Parks, William Matthew. "The interaction between DNA gyrase and the peptide antibiotic Microcin B17." Thesis, University of East Anglia, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426951.
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25
Still, Patrick C. "Cytotoxic Alkaloids from Microcos paniculata with Activity at Neuronal Nicotinic Receptors." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1365688930.
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26
Woolridge, Daniel 'Shane'. "An Open Architecture Approach to Networked Telemetry System." International Foundation for Telemetering, 2010. http://hdl.handle.net/10150/605942.
Повний текст джерелаАнотація:
ITC/USA 2010 Conference Proceedings / The Forty-Sixth Annual International Telemetering Conference and Technical Exhibition / October 25-28, 2010 / Town and Country Resort & Convention Center, San Diego, CaliforniaWhen designing data transport systems, Telemetry and Communications engineers always face the risk that their chosen hardware will not be available or supported soon after the hardware has been installed. The best way to reduce this risk and ensure the longevity of the system is to select an open architecture standard that is supported by multiple manufacturers. This open architecture should also have the ability to be easily upgraded and provide for all of the features and flexibility that are required to be a reliable carrier-grade edge-device. The PCI Industrial Computer Manufacturers Group (PICMG) developed the MicroTCA open standard to address the specific needs of these Communications and Network System Engineers. This paper describes the MicroTCA architecture and how it can be applied as the ideal edge-device solution for Networked Telemetry Systems applications.
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Kumar, Y. Ashok, T. J. Aprem, and M. Nadar. "MULTI FUNCTION RF MODULE." International Foundation for Telemetering, 1996. http://hdl.handle.net/10150/608380.
Повний текст джерелаАнотація:
International Telemetering Conference Proceedings / October 28-31, 1996 / Town and Country Hotel and Convention Center, San Diego, CaliforniaGenerally, to meet the Telemetry and Tracking functions in space probes, RF packages are realised using dedicated circuit configurations and different building blocks. While this approach is warranted for certain Space missions, for some Space programmes, which are basically Technology demonstrators and where the main emphasis is on higher flexibility with minimal complexity - usage of multifunction RF modules (MFRM), would be highly avantageous. The MFRM, which can be considered as a RF package, has a flexible configuration and is built around Common basic building blocks like broadband MMIC, wide band amplifiers, switches, Dielectric Resonant Oscillators (DRO), Numerically Controlled Oscillators (NCO), etc. It also has a Microcontroller, whose function is to select the required configuration and make necessary interconnections between the building blocks, so as to achieve a specific end function, based on the pre set commands from system designer. The commands can either be preprogrammed or they can be through uplink Telecommand signals from the ground stations. A brief outline of the results of the proto unit of a MFRM which can be configured for different end RF functions, through a microcontroller is presented in the paper. It is expected that in Space missions like LEO programmes, Microsats, Reentry, Microgravity experiments etc, the MFRM approach would offer greater flexibility to the system designer at reduced-cost, complexity and production turn around time.
28
Sundqvist, Philip. "MicroCT system software updateand implementation of a beamhardening correction method." Thesis, KTH, Skolan för teknikvetenskap (SCI), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-188924.
Повний текст джерелаАнотація:
The School of Technology and Health, STH, has been developing a micro-CTscanner for pre-clinical imaging. The scanner consists of an X-ray tube and aflat panel sensor fixated on a gantry rotating around the object to be imaged. Acomputer located on the gantry runs an acquisition software for communicationbetween the devices on the gantry as well as for controlling them. For this thesisthe acquisition software has been significantly improved in terms of functionality,performance, usability and user-adaptivity.Projection images acquired by the microCT are created by measuring theX-ray beam attenuation as a function of spatial location. Using all projectionimages, a 3-dimensional image can be reconstructed giving a map of the attenuationinside the object, thus providing information about its internal structure.A common artifact for CT-scanner images is the cupping arti fact which the attenuation in the middle of an object is underestimated due to beam hardening.For the second part of this thesis, a method for correcting for this artifact hasbeen implemented and tested. The cupping artifact was successfully removedin most cases, although it was shown that for some situation it is not applicable
29
Krause, Lauren Kendall. "Gene Expression patterns in High-Altitude Pulmonary Edema: A Gene Microway Analysis." Yale University, 2008. http://ymtdl.med.yale.edu/theses/available/etd-08152007-111828/.
Повний текст джерелаАнотація:
Multiple modulating genes and environmental factors have been implicated in the pathogenesis of high-altitude pulmonary edema (HAPE). However, at the present time, there exists an incomplete understanding of the molecular mechanisms and pathways which underlie constitutional susceptibility. Genome-wide measurements of gene expression in peripheral blood mononuclear cells (PBMCs) were performed using microarray technology. Comparison of gene expression profiles of HAPE-susceptible and resistant individuals resulted in the identification of several previously undescribed candidate genes. RhoA and Rho-kinase (ROCK), regulators of vascular smooth muscle contraction, were differentially regulated in the HAPE-susceptible cohort, as compared to both HAPE-resistant patients with acute mountain sickness (AMS+) and healthy controls (p=0.0014; p=0.0020). Furthermore, biological pathways involving RhoA and Rho-kinase were strongly upregulated in subjects with HAPE. These findings represent the first description of the RhoA/Rho-kinase signaling pathway in HAPE. Currently, few pharmacologic therapies have been demonstrated to be effective in the prevention and treatment of HAPE. The results of this study provide early evidence that Fasudil, a selective Rho-kinase inhibitor, may represent a novel therapeutic intervention effective in the prevention and/or treatment of high-altitude pulmonary edema.
30
Albert, Keith J. "Microbead array-based artificial nose : explosives detection and simple/complex odor discrimination /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2001.
Знайти повний текст джерелаАнотація:
Thesis (Ph.D.)--Tufts University, 2001.Adviser: David R. Walt. Submitted to the Dept. of Chemistry. Includes bibliographical references. Access restricted to members of the Tufts University community. Also available via the World Wide Web;
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Campbell, John A. "FORTRAN programs for aerodynamic analyses on the MicroVAX/2000 CAD/CAE workstation." Thesis, Monterey, California. Naval Postgraduate School, 1988. http://hdl.handle.net/10945/23241.
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Elizondo, Martinez Jorge. "Microrid operation strategy for improved recovery and inertial response after large disturbances." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/105659.
Повний текст джерелаАнотація:
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2016.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 177-183).
The electric grid is one of the major achievements of human kind. In the last hundred years it has grown from small clusters of generation and loads, into large networks containing millions of elements and spanning entire continents. Recently, the increasing deployment of distributed generators (DGs) has triggered a grid transformation from a rigid to a flexible and de-centralized structure. Microgrids are an essential element in this transformation because by grouping DGs and loads into controllable units, they can provide a coordinated response to maximize their impact on the grid. Microgrids are inherently different from the larger grid. This thesis shows how by challenging the paradigm of constant frequency and voltage operation, a new strategy can be implemented to achieve an improved response after large disturbances without compromising safety. Large disturbances are commonly encountered in the grid and disrupt the power balance that is required for a reliable operation. If the imbalance is large enough and the proper actions are not taken, then a blackout will occur, affecting millions of people and creating a severe economic impact. To demonstrate the advantages of the proposed operation strategy, two large disturbances are studied: a fault in the distribution network that creates a reactive power imbalance due to induction motor stalling, and a sudden change in generation or consumption that leads to a real power imbalance. In the first part, a framework is created to study fault events and then used to describe a fault recovery strategy that expands the stability region of the system. In the second part, the proposed operation strategy is presented as a new control technique that allows energy to be extracted from the induction motors in the system to achieve an inertial response and provide frequency regulation. All the results are validated using a microgrid experimental set-up that was built as part of this thesis.
by Jorge Elizondo Martinez.
Ph. D.
33
Thierry, Maxime. "Developing and enriching a guidance library for the Earth Observation Satellite MicroCarb." Thesis, KTH, Rymdteknik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-235970.
Повний текст джерелаАнотація:
My Master Thesis takes place in the context of the MicroCarb mission. The goal of this mission is to identify the sinks and the sources of carbon dioxide on Earth in order to map them and to improve the knowledge of its cycle. To fulfill this mission, some particular guidance modes must be implemented in order to study their feasibility. My thesis consisted in defining and enriching the algorithms used to define the guidance laws, by implementing new tools and a new guidance law, and studying the induced performances in terms of data acquisition and with respect to the constraints related to the satellite. Alongside with this mission, the implementation of those elements support the development of the guidance library POLARIS, actual in its early phase, which is at first only dedicated to MicroCarb but which is intended to become multimissions. First, I describe the CNES as well as the guidance team I worked in. Then, the context of the Master Thesis is introduced. Once the context is established we will focus on the first elements I have been working on, as part of the Dazzling studies. Indeed, the spectrometer used in MicroCarb is very sensitive and has to be maintained at very low temperature. Thus the passive cooling mechanism must be protected from the Sunlight and from the light reflected by the Earth. I had to use a class of the Space mechanics library PATRIUS, called Assembly, in order to materialize the satellite and its numerous parts. Once implemented, I was able to perform some Dazzling Studies, highlighting some issues with the various strategies that were considered, and opening new perspectives. Moreover, a problem was detected on a crucial function of the guidance laws calculator. Once a new function was compiled, I had to made a cross validation using Scilab, and results were positive. This part will end with a Geometric Cape study, realized in order to quantify the influence of the satellite, and the MCV roll, over the Geometric Shifting. In the second part, we will introduce a guidance law which was not implemented initially, and on which I had to work during the last weeks of the thesis: The City mode. Although this mode is similar to an existing calibration mode, it has its own characteristics I had to take into account. The code for this acquisition mode worked well, but the results were not satisfying, considering the Dazzling problem and the kinematic constraints. Thus new strategies had to be considered, and more particularly the 2-scans mode. This mode brought a lot of satisfactions, but there is still more work to be done. This report ends with a general conclusion about my work and some perspectives which could be considered for future studies. I also present my personal contribution and some encountered difficulties I had to deal with.Examensarbetet fokuserade på rymduppdraget MicroCarb. Målet med detta uppdrag är att identifiera koldioxidsänkor och -källor på jorden för att kartlägga dem och förbättra kunskapen om deras cykler. För att uppfylla detta uppdrag måste vissa specifika styrningsmoder implementeras för att studera uppdragets genomförbarhet. Detta bestod i att definiera och förfina de algoritmer som användes för att definiera siktningslinjer, genom att implementera nya verktyg och en ny styrning samt studera prestandan när det gäller datainsamling och utifrån begränsningar hos satelliten. Detta uppdrag stöder utvecklingen av vägledningsbiblioteket POLARIS, i dess tidiga fas, som i första hand är avsedd för MicroCarb men som också är avsett att användas i flera kommande uppdrag. Arbetet inleds med en beskrivning av CNES, där examensarbetet utfördes, samt den grupp jag arbetade inom. Därefter presenteras motivation och sammanhanget. Sedan inriktas fokus mot de första elementen jag har arbetat med som en del av de bländande studierna. Spektrometern som används i MicroCarb är mycket temperaturkänslig och måste hållas vid mycket låg temperatur. Således måste den passiva kylmekanismen skyddas mot solljus samt från det ljus som reflekteras från jorden. En klass inom rymdmekanikbiblioteket PATRIUS, kallad Assembly, användes för att modellera satelliten och dess många delar. Därefter utfördes preliminära bländande studier, med fokus på några problem med de olika styrningsstrategier som föreslagits, vilket öppnade nya perspektiv. Dessutom upptäcktes ett problem med en avgörande funktion i siktlinjens räknare. När en korrigerad funktion sammanställts, utfördes en korsvalidering med mjukvaran Scilab, och resultaten var positiva. Denna del avslutas med en geometrisk studie för att kvantifiera påverkan av satelliten och instrumentrullningen på den geometriska skiftningen. Den andra fasen i arbetet var implementering av en ny funktionalitet kallad Stadsläget. Även om det här läget liknar ett befintligt kalibreringsläge, har det egna egenskaper som måste tas hänsyn till. Beräkningskoden för detta läge fungerade bra, men resultaten var inte tillfredsställande utifrån bländningsproblemet och kinematiska begränsningar. Därför beaktades nya strategier, i synnerhet ett nytt skanningsläget med två avskanningar. Detta läge gav bättre resultat, men behöver utvecklas ytterligare. Rapporten avslutas med förslag på fortsatt arbete och personliga reflektioner.
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McDonough, John Edward. "Use of CT and MicroCT to quantify structures in human lungs." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42034.
Повний текст джерелаАнотація:
MicroCT is a technology that allows for obtaining images with resolution equivalent to histological sections from volumes of tissue that would be prohibitive to examine by classical sectioning techniques. In this dissertation, three studies are reported that make novel use of microCT to quantify structures within lung tissue. In the first study, microCT was used to quantify the number of alveoli within normal human lungs. The data show that alveolar number can vary throughout the lung with more alveoli per volume of lung present in the apex of the lung compared to the base. In the second study, airway dimensions from normal human lungs and lungs from patients with advanced COPD were measured on microCT images and compared to measurements made on the same airways obtained using lower resolution MDCT images. These measurements confirmed that MDCT overestimates measurements of the airway wall and underestimate measurements of the airway lumen. As well, microCT was able to show a correlation of airway wall thickness to the extent of emphysema within the lung but no correlation was found when measurements from MDCT were used. This suggests that microCT is able to detect more subtle changes in the airway wall dimensions that MDCT could not. In the third study, microCT was used to quantify the numbers and lumen area of terminal bronchioles in normal human lungs and lungs from patients with advanced COPD. We found that terminal bronchiole dimensions and number from normal lungs were similar to the classical data. As well, we found a marked reduction in the number of terminal bronchioles and a narrowing of the lumen of these airways in the lungs of patients with COPD. Remarkably, we found these changes occurred in regions of the lung with minimal emphysematous destruction, suggesting that these changes occur before parenchymal destruction takes place. These three studies show that microCT is an important and underutilized imaging technology to examine the lung and its use will likely be expanded in futures studies to examine the pathological changes that occur in the tissue structure of other lung diseases.
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Smith, Sheryl Dianna. "The Influence of Water Quality on Arsenic Sorption and Treatment Process Performance." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/33581.
Повний текст джерелаАнотація:
A new regulation has been proposed that would lower the acceptable level of arsenic in drinking water from the current standard of 50 ppb. Therefore, research into effective arsenic removal treatment is important, especially for hard to treat waters with high concentrations of silica.
The first phase of research was designed to determine if sand ballasted coagulation is a viable means of removing arsenic from drinking water, and if so, to identify the water qualities in which the technology performs best. A jar test protocol was developed and tested on a wide range of waters to compare microsand ballasted coagulation and other coagulation based treatment processes in terms of arsenic removal. Secondary impacts of the microsand process such as residual turbidity, iron, post-treatment membrane filter run length, and TOC removal were also considered as part of this evaluation. Microsand ballasted coagulation provided promising results for many of the simulated groundwater test conditions in which more than 80% of the arsenic regulation costs will be incurred. However, like conventional coagulation/sedimentation, microsand ballasted coagulation performed poorly in waters with high silica and high pH.
Thereafter, a second phase of research more closely examined the kinetic behavior of arsenic sorption to amorphous and granular oxides in the presence of silica and calcium. At pH 8.5, calcium dramatically improved arsenic sorption to amorphous iron hydroxide in the presence of silica over short reaction times, but had no long-term advantage. This result could have considerable applications for treatment in that it suggests water quality controls the required reaction times. Additionally, batch tests indicated that activated alumina granular media was more sensitive to water quality than granular ferric hydroxide; however, calcium eliminated silica interference to arsenic sorption onto activated alumina.Master of Science
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Larabee, Fredrick J., Wulfila Gronenberg, and Andrew V. Suarez. "Performance, morphology and control of power-amplified mandibles in the trap-jaw ant Myrmoteras (Hymenoptera: Formicidae)." COMPANY OF BIOLOGISTS LTD, 2017. http://hdl.handle.net/10150/625752.
Повний текст джерелаАнотація:
Trap-jaw ants are characterized by high-speed mandibles used for prey capture and defense. Power-amplified mandibles have independently evolved at least four times among ants, with each lineage using different structures as a latch, spring and trigger. We examined two species from the genus Myrmoteras (subfamily Formicinae), whose morphology is unique among trap-jaw ant lineages, and describe the performance characteristics, spring-loading mechanism and neuronal control of Myrmoteras strikes. Like other trap-jaw ants, Myrmoteras latch their jaws open while the large closer muscle loads potential energy in a spring. The latch differs from other lineages and is likely formed by the co-contraction of the mandible opener and closer muscles. The cuticle of the posterior margin of the head serves as a spring, and is deformed by approximately 6% prior to a strike. The mandibles are likely unlatched by a subgroup of closer muscle fibers with particularly short sarcomeres. These fast fibers are controlled by two large motor neurons whose dendrites overlap with terminals of large sensory neurons originating from labral trigger hairs. Upon stimulation of the trigger hairs, the mandibles shut in as little as 0.5 ms and at peak velocities that are comparable with other trap-jaw ants, but with much slower acceleration. The estimated power output of the mandible strike (21 kW kg(-1)) confirms that Myrmoteras jaws are indeed power amplified. However, the power output of Myrmoteras mandibles is significantly lower than distantly related trap-jaw ants using different spring-loading mechanisms, indicating a relationship between power-amplification mechanism and performance.
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König, Martin. "Stereoselektive Synthese verschiedener beta-Amino- und Microcos-Piperidinderivate : Versuche zur Totalsynthese von (+)-Microconin." kostenfrei, 2009. http://www.opus-bayern.de/uni-wuerzburg/volltexte/2009/4004/.
Повний текст джерела
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Kielar, Kayla N. "Bone marrow dosimety [sic] via microCT imaging and stem cell spatial mapping." [Gainesville, Fla.] : University of Florida, 2009. http://purl.fcla.edu/fcla/etd/UFE0024755.
Повний текст джерела
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Schley, Jeremiah P. "Single Cell Culture Wells (SiCCWells)." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1406292709.
Повний текст джерела
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Picoy, Romero Diana. "Clima organizacional en establecimientos de salud de la MICRORED villa en el año 2014." Bachelor's thesis, Universidad Ricardo Palma, 2016. http://cybertesis.urp.edu.pe/handle/urp/720.
Повний текст джерелаАнотація:
Objetivo: El presente trabajo tiene como objetivo conocer el Clima Organizacional en Establecimientos de Salud de la Micro Red Villa en el año 2014.
Materiales y métodos: el tipo de estudio de esta investigación es observacional, descriptivo y transversal; ya que permite presentar hallazgos tal como se presentan en un tiempo y espacio determinado. La muestra estuvo conformada por todos los trabajadores asistenciales y administrativos en actividad laboral durante el año 2014 de los 13 establecimientos de salud de la Micro Red Villa. La muestra se calculó de acuerdo a lo propuesto a la R.M.Nº 623-2008/MINSA al 50% mas 1 del total de trabajadores de cada establecimiento, así mismo se consideró un 10% adicional para salvaguardar el tamaño mínimo de la muestra.
Resultados: El Clima Organizacional percibido por los trabajadores de los Centros de Salud que pertenecen a la Micro Red Villa alcanza un puntaje es de 74.64; donde Cultura Organizacional tiene un puntaje 74.62, Diseño Organizacional tiene un puntaje de 24.84 y Potencial Humano tiene un puntaje de 25.59
Conclusiones: El Clima Organizacional en Establecimientos de Salud de la Micro Red Villa es “Por Mejorar”. La variable Cultura Organizacional es calificada como “Saludable”. La variable Diseño Organizacional es calificada como “Por Mejorar”. La variable Potencial Humano es calificada como “Por Mejorar”.
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Mahmood, Zuhdi Ahmad Wafi. "High performance drive circuits for integrated microLED/CMOS arrays for visible light communication (VLC)." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/10006.
Повний текст джерелаАнотація:
Wireless communication is a form of communication that has been around for over hundreds of years and is the fastest growing segment of the communication industry. Today, wireless communication has become an essential part of almost everyone’s daily life, and the number of users has increased exponentially over the last decade with the introduction of the internet, mobile devices and smart phones. Radio Frequency (RF) transmission is arguably the most popular method of communication and is available worldwide. With the rapid progress in technology and the increase of number of users, the limited RF spectrum is becoming more congested which led to numerous research efforts to find an alternative that can help to alleviate the pending problem. One of the proposed solutions is Visible Light Communication (VLC), which uses visible Light Emitting Diode (LED) for data transmission. In this thesis, three integrated microLED/Complementary Metal Oxide Semiconductor (CMOS) Integrated Circuits (ICs) are presented with the main aim of increasing the data rate of transmission. The first microLED/CMOS IC presented here is the Generation V microLED/CMOS driver which represents the continuation of the earlier work in the HYPIX project, which aimed to develop a microLED/CMOS driver to optically pump an organic polymer laser. A 40x10 pixelarray of Generation V microLED/CMOS driver was thus designed, primarily for optical pumping polymer lasing purposes, but has also demonstrated the ability to perform communication transmission using an On-Off Keying (OOK) modulation scheme. The driver consumes up to 330mA current and produces approximately 12mW of optical power from a single pixel, which is about 3 times higher than its predecessor. The second microLED/CMOS IC is the microLED/CMOS Current Feedback (CCFBK) driver which was designed to facilitate Orthogonal Frequency Division Multiplexing (OFDM) modulation. OFDM is one of the modulation schemes, adopted from the RF domain, that was proposed to be implemented in VLC in order to increase the data transmission rate. To the best of the author’s knowledge, the microLED/CCFBK driver is the first CMOS driver for microLED that was designed to perform analogue modulation for VLC purposes. The driver is characterised and shows the ability to produce up to 3.5mW of optical power with a data transmission rate of up to 486Mbit/s. The microLED/CMOS Optical Feedback (COFBK) driver is the third microLED/CMOS IC presented in this thesis. The driver looks to improve on the performance of the microLED/CCFBK driver. OFDM transmission requires high linearity to ensure low Bit Error Rate (BER) transmission. However, the optical power output of an LED is not, in general, linear with the input voltage signal. The microLED/COFBK driver looks to increase the linearity of the optical power output by integrating a microLED and a photodiode in a single pixel to create a feedback loop. Once again, to the best of the author’s knowledge, the microLED/COFBK driver is the first CMOS driver for microLED which integrates both optical source and sensor in a single pixel to help linearise the optical power output for communication purposes; in this case, VLC. For a similar range of optical power, the microLED/COFBK driver shows a reduction about 5.3% in the degree of non-linearity compared to the microLED/CCFBK driver and produces lower Total Harmonic Distortion (THD). The microLED/COFBK driver showed the potential to increase the data rate by a factor of four over that of microLED/CCFBK driver. The analogue modulated microLED/CMOS ICs described here are the first-generation drivers that have demonstrated the possibilities to increase the data rate using OFDM. A number of possible design improvements have been identified which will enhance future performance and integration with the standard VLC system.
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Costa, Ruan Rodrigo Ara?jo da. "A rela??o entre desempenho e a forma legal das institui??es de microcr?dito." Universidade Federal do Rio Grande do Norte, 2015. http://repositorio.ufrn.br/handle/123456789/19669.
Повний текст джерелаАнотація:
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O trabalho investigou a rela??o entre o desempenho e as formas legais adotadas por institui??es de microcr?dito (IMC?s). As IMC?s estudadas adotaram forma legal de banco, organiza??o n?o governamental, cooperativa, institui??o financeira n?o banc?ria ou banco rural. Os dados utilizados compreendem seis anos, de 2007 a 2012, com periodicidade anual. Foi empregado o modelo de regress?o em painel e vari?veis dummy representando as formas legais. Formaram a amostra 243 IMC?s de cinquenta pa?ses, origin?rios de todos os continentes do mundo, exceto a Am?rica do Norte. No trabalho, foi observado que IMC?s maiores conseguem lucros maiores, retornos maiores e ?ndices de autossufici?ncia operacional maiores, indicando que o crescimento pode levar ? consolida??o das IMC?s e que as IMC?s menores poderiam buscar fus?es os assimula??es com outras IMC?s para se consolidarem. Tamb?m foi observado que as cooperativas, as institui??es financeiras n?o banc?rias e os bancos rurais conseguem atender mais clientes, causando maior impacto na sociedade, e obter maiores retornos, indicando que as formas legais mais adequadas ao mercado de microfinan?as aparentemente s?o as cooperativas, institui??es financeiras n?o banc?rias e bancos rurais pois os resultados indicam que as IMC?s que adotam tais formas legais equilibram a orienta??o para o social e a busca por por maiores lucros.
This work test the relationship of performance and legal form of microfinance institutions (MFI), in our work MFI can be banks, non-governmental organizations (NGO), cooperatives, non-banks financial institutions (NBFI) or rural banks. We use linear regression model, panel data and variables dummy for the legal forms. Our samples are 243 MFI from all continents, except North America, in the period from 2007 to 2012. We found that bigger MFI generates higher profit, higher returns and higher self-sufficiency rates, so the growing can be a way for consolidation of MFI. For smaller MFI a way can be assimilation or merging with other MFI. Cooperatives, non-bank financial institutions and rural banks can serve more customers, causing greater impact on society, and get higher returns. This suggests the most appropriate legal form for microfinance market can be cooperatives, non-banks financial institutions or rural banks balancing social orientation and profit orientation.
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Mangione, Francesca. "Cell-based partial pulp regeneration in a porcine preclinical model." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB046/document.
Повний текст джерелаАнотація:
La pulpe dentaire est un tissu connectif innervé et vascularisé, contenu dans une structure minéralisée inextensible formée par l’émail, la dentine et le cément. Ce tissu assure l’homéostasie et la sensibilité de la dent. Il est sujet à des lésions sévères faisant suite à une carie ou à un traumatisme. La thérapeutique conventionnelle préconisée alors est le traitement endodontique, qui consiste en l’exérèse de la totalité du tissu pulpaire et le comblement de l’espace évidé par un matériau synthétique bioinerte. Malgré les résultats cliniques satisfaisants, cette thérapeutique induit une fragilisation de la dent et une plus grande susceptibilité aux infections, qui peuvent conduire à terme à la perte de la dent. En se basant sur la présence de cellules souches mésenchymateuses dans la pulpe dentaire, des stratégies de régénération alternatives au traitement endodontique traditionnel sont à l’étude, afin de permettre le maintien des fonctions de nutrition et de sensibilité de la pulpe, garantes de la pérennité de la dent sur l’arcade. Elles s’inscrivent dans deux approches: la régénération de novo, en cas de nécrose du tissu pulpaire et la régénération partielle, lorsque seul le tissu pulpaire endommagé est éliminé et régénéré. Nos travaux portent sur la faisabilité de cette dernière approche dans un modèle préclinique. En effet, dans la perspective d’un transfert vers la clinique humaine, des modèles chez le gros animal doivent être développés afin de tester la faisabilité et le succès de cette thérapie, dans des conditions proches de la clinique. Du fait de ses similitudes avec l’homme en termes d’anatomie et de physiologie, le miniporc représente un modèle de choix pour les études précliniques d’ingénierie pulpaire. L’objectif principal de cette étude est de tester la faisabilité de la régénération pulpaire partielle, en implantant des cellules pulpaires porcines (pDPCs) contenues des hydrogels injectables dans des défauts pulpaires artificiellement créés chez le miniporc. Au cours ce travail, différentes techniques d’imagerie d’évaluation du processus de régénération ont été développées. En particulier, un protocole d’angiographie tridimensionnelle in- pour la visualisation du réseau vasculaire pulpaire a été mise au point. Par ailleurs, en utilisant des paramètres morphométriques spécifiques, initialement développés pour caractériser l’os, une analyse tridimentionnelle par micro-CT des tissus minéralisés de réparation a été élaborée. En appliquant un “split mouth model”, les hydrogels injectables ensemencés ou non par des pDPCs ont été implantés dans des molaires et des prémolaires, après amputation de la pulpe camérale. À 21 jours après la chirurgie, les analyses d’imagerie, d’histologie et d’immunologie ont mis en évidence, qu’indépendamment de la présence des pDPCs, l’implantation des hydrogels a induit la formation d’un pont d’ostéodentine. La caractérisation morphométrique tridimensionnelle a montré que la microarchitecture de ce pont différait largement de la dentine native. De plus, en présence des pDPCs, le processus de réparation était modifié, avec une moins bonne étanchéité du pont. Au cours de ce travail, une technique de suivi non invasive de la régénération a tenté d’être mise au point. Une angiographie tridimensionnelle par soustraction a été réalisée avant et après la procédure de régénération pulpaire partielle. Si les angiographies ont révélé l’entière vascularisation des mâchoires et des dents à croissance continue, l’apport vasculaire des dents matures traitées, du fait de son faible flux, n’a pas pu être mis en évidence. L’absence de régénération partielle de la pulpe dans les conditions testées souligne l’importance des modèles précliniques pour identifier les facteurs promouvant un environnement favorable à la régénération, dans la perspective d’un transfert vers la clinique humaineThe dental pulp is a connective tissue, which is highly innervated and vascularized, encapsulated in a mineralized inextensible structure formed by enamel, dentin and cementum, ensuring the homeostasis and sensibility of the tooth. The pulp is often damaged by caries and trauma, resulting in infection or necrosis. In such situations, the routine clinical treatment is a root canal therapy, which consists in the elimination of the affected tissue and filling of the endodontic canal system with bioinert synthetic materials. In spite of satisfactory clinical outcomes, none of the original functions is restored and the lack of sensitivity as well as natural defence may lead to tooth fracture and reinfection. Cell-based pulp regeneration could provide a valid alternative to traditional endodontic treatment of damaged teeth. This strategy focuses, in fact, on the preservation of the healthy pulp tissue and the regeneration of the damaged one, by combining stem cells, scaffolds and growth factors. In case of trauma or carious lesion, as the pulp inflammatory reaction is compartmentalized in first instance, such conservative approach could be indicated. Regarding non-rodent animal model, to our knowledge, only Iohara et al. (2009) reported the achievement of partial pulp regeneration in canine tooth by implantation of subfractions of autologous pulp cells; however, in the perspective of a transfer to the human clinic, larger animal models should be developed to test the feasibility and the success of the therapy mimicking the clinical conditions of pulpotomy. Due to dental anatomical and physiological similarities with human, the minipig constitutes a model of choice for preclinical pulp engineering studies. The aim of this study was to develop a preclinical model of partial dental pulp regeneration in minipig, by implanting a pulp construct, made by self-assembling nano-peptide injectable hydrogel and porcine minipig dental pulp cells (pDPCs), in artificially created pulp defects. Secondarily, in the context of this preclinical model, two different techniques of analysis of the regeneration process have been developed. In particular, an in vivo 3D subtraction angiography has been set for the visualization of dental pulp vascular network. Indeed, further developments of this modality open promising perspectives of its application for the morphometric characterization of angiogenesis process in newly formed dental tissues and bone defects. Moreover, using specific morphometric parameters, initially developed to characterize bone, a micro-CT morphometric analysis of the mineralized reparative tissues, obtained by the partial pulp regeneration protocol, has been elaborated. By split mouth model, pulp constructs made with self-assembling injectable nano-peptide hydrogel with and without porcine dental pulp cells (pDPCs) were implanted, after pulp chamber amputation in premolars and molars. At day 21 after surgery, three-dimensional morphometric characterization, Masson’s trichrome and immunolabeled for DSP and BSP were performed on treated teeth. 3D subtraction angiographies have been performed before and after partial pulp regeneration procedure. Regardless of the presence of pDPCs, the implantation of pulp construct induces the formation of an osteodentin bridge, whose microarchitecture sensibly differs from the native dentin. Furthermore, the presence of pDPCs in the construct slightly impairs this reparative process. The latter was led the remaining pulp cells, instead of the pDPCs in the scaffold. Angiographies could show entire vascularization of jaws and continuously growing teeth but blood supply of treated mature permanent teeth could not be displayed. The failure of partial pulp regeneration cell based strategy, in these near-real clinical conditions, highlights the importance of preclinical models, to identify the factors promoting a favourable regenerative environment, in the perspective of a transfer to the human clinics
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Chen, Yuan. "Verification and validation of MicroCT-based finite element models of bone tissue biomechanics." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/13602/.
Повний текст джерелаАнотація:
Non-destructive 3D micro-computed tomography (microCT) based finite element (microFE) model is popular in estimating bone mechanical properties in recent decades. From a fundamental scientific perspective, as the primary function of the skeleton is mechanical in nature, a lot of related biological and physiological mechanisms are mechano-regulated that becomes evident at the tissue scale. In all these research it is essential to known with the best possible accuracy the displacements, stresses, and strains induced by given loads in the bone tissue. Correspondingly, verification and validation of the microFE model has become crucial in evaluating the quality of its predictions. Because of the complex geometry of cancellous bone tissue, only a few studies have investigated the local convergence behaviour of such models and post-yield behaviour has not been reported. Moreover, the validation of their prediction of local properties remains challenging. Recent technique of digital volume correlation (DVC) combined with microCT images can measure internal displacements and deformation of bone specimen and therefore is able to provide experimental data for validation. However, the strain error of this experimental method tends to be a lot higher (in the order of several thousand microstrains) for spatial resolutions of 10-20 µm, typical element size of microFE models. Strictly speaking no validation of strain is possible. Therefore, the goal of this thesis it to conduct a local convergence study of cancellous bone microFE models generated using three microCT-based tissue modelling methods (homogeneous tetrahedral model, homogeneous hexahedral model and heterogeneous hexahedral model); to validate these models’ prediction in terms of displacement using the novel DVC technique; and finally to compare the strain field predicted by three tissue modelling methods, in order to explore the effect of specific idealisations/simplifications on the prediction of strain.
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Reina, Nicolas. "Les contraintes de charge asymétriques chez l'homme moderne : étude microCT sur l'os trabéculaire." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30002/document.
Повний текст джерелаАнотація:
L'étude de l'os est d'un intérêt majeur en Anthropologie. Constituant la charpente des vertébrés, le squelette est le reflet de l'activité motrice. En effet, chaque élément du squelette a une fonction dictée par sa forme et un rôle autorisé par sa morphologie. C'est l'illustration la plus visible de l'adaptation. Ce processus est largement étudié dans la lignée humaine et ce dogme est au cœur de nombreuses recherches en Anthropobiologie. Ces caractères sont inscrits dans la forme de l'os. Chaque courbure, apophyse ou crête témoignent au moins en partie de l'action d'un muscle ou d'une fonction dictée par un lent processus évolutif voire adaptatif. Cette évolution se fait par l'évolution de caractères externes de l'os par sa forme ou l'anatomie " visible " d'une part et par l'évolution de caractères plus internes, subtils et directement lié aux propriétés biomécaniques de l'os à savoir l'os trabéculaire. L'os trabéculaire est un matériau plus fragile, déformable que l'os cortical. Il constitue une trace indirecte des contraintes appliquées squelette. C'est ainsi que les activités locomotrices, alimentaires ou occupationnelle seront inscrite dans l'endostructure osseuse. C'est la théorie développée par Wolff dès 1870 dans " The law of bone remodelling ". Il développa cette conception d'un processus actif, évolutif par l'observation macroscopique des travées de l'extrémité supérieure du fémur chez l'homme. Si la contrainte exercée sur un os en particulier augmente, il va se remodeler pour devenir plus rigide et résister à la charge dans ce segment d'os particulier et pour cette force particulière de contrainte. Nous avons étudié cette théorie sur deux modèles chez le vivant au niveau du membre supérieur et au niveau du membre inférieur pour caractériser les contraintes asymétriques appliquées à l'os trabéculaires. La latéralité ou préférence manuelle est un exemple d'activité asymétrique. Ses effets sur l'os sont bien connus lors de la pratique de sports intensifs ou d'activités très latéralisées. Cependant peu de données existent sur les activités usuelles et la préférence manuelle de l'homme jeune sans activité particulière. Par une étude en microscanner avec des coupes de 41 microns, des volumes d'intérêt dans les os du squelette carpien radial ont été réalisés sur des individus d'âge jeune sans antécédent particulier de façon bilatérale. Plusieurs variables cliniques et anthropométriques ont également été recueillis. Nous avons pu mettre en évidence des caractères endostructuraux expliquant la variabilité interindividuelles en les comparant avec des éléments anthropomorphiques et la force de serrage manuelle. Par ailleurs, les défauts d'axe en varus ou en valgus exercent des contraintes asymétriques également sur les articulations portantes. La chirurgie prothétique du genou croit ces dernières années de façon exponentielle par un effet conjoint de l'amélioration des techniques, et l'augmentation de l'incidence de l'arthroseThe study of bone is of major interest in Anthropology. The skeleton is an image of motor activity. Indeed, every element of the skeleton has a function dictated by its shape and role and then by its morphology. This illustrates the most visible adaptation of the bone. This process is widely studied in the human lineage. This theory is an important path of research in Anthropology. These characters are inscribed in the shape of the bone. Each curve, or crest reflect the action of a muscle or a function dictated by a slow evolutionary process. This change is by changing external characteristics of the bone by its form or anatomy "visible" on the one hand and by the evolution of more internal character, subtle and directly related to the biomechanical properties of bone namely trabecular bone. Trabecular bone is a more brittle material, deformable than cortical bone. It is an indirect trace of the stresses applied to the bone. Thus locomotion, feeding or occupational activities can be analyzed into the bone endostructure. This is the theory developed by Wolff in 1870 in "The law of bone remodeling." He developed this idea of ??an active, evolving process by macroscopic observation of the spans of the proximal femur in humans. If the stress on a particular bone increases, it will remodel to become more rigid and withstand the load in that particular bone segment and for this particular force of constraint. We studied this theory on two models in the living human being. One concerned the upper limb and the second the lower limb to characterize asymmetrical forces on trabecular bone. Laterality or handedness is an example of asymmetrical activity. Its effects on bone are well known in the practice of intensive sports or very lateralized activities. However, little data exist on the usual activities and the handedness of the young man with no particular activity. We performed a microCT study with cuts 41 microns slices. Volumes of interest in radial carpal bones were performed on both sides on young human adults without particular medical history. Several clinical and anthropometric variables were also collected. We were able to highlight endostructural patterns explaining the interindividual variability in comparison with anthropometric parameters and crush or pinch grip. Furthermore, axis deviations in varus or valgus exert asymmetric constraints also on weight-bearing joints. The prosthetic knee surgery increases exponentially in the last decades by a combined effect of improved techniques and the increased incidence of osteoarthritis. The OA is multifactorial but the weight has a major effect on cartilage wear. We further know that the morphology and deformation of members influence this phenomenon. We wanted to characterize the response of the bone to endostructure these asymmetrical stresses on the tibial plateau. We collected tibial plateaus during total joint replacement surgeries for knee and compare the bone under chondral internal and external with microCT 7.4 micron slices. Some parameters highlight the major effect weight and body mass such as bone volume fraction BV/TV, structure model index SMI, trabecular space Tb. and trabecular number Tb.N. Subchondral densification during osteoarthritis is associated with a reduction in its elastic modulus, which could increase cartilage stress, and accelerate cartilage loss
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Liu, Cheyenne H. "Development and Characterization of Reagent Pencils for Microfluidic Paper Based Analytical Devices." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1639.
Повний текст джерелаАнотація:
Microfluidic paper based analytical devices (microPADs) are a novel platform for point of care (POC) diagnostics. Limitations of reagent shelf life have been overcome with the introduction of reagent pencils as a method for solid-based reagent deposition. While useful, little work has been reported on the characterization and optimization of reagent pencils. Herein, an investigation on reagent pencil composition and efficiency is conducted via colorimetric release profile tests utilizing an erioglaucine disodium salt that yields a quantifiable blue colored product in the presence of water. Within this work, an investigation on the molecular weight dependence, polymer chain end functionality, and polymer-graphite ratio was conducted to determine the most desirable parameters in reagent pencil composition. Further, the effects of enzyme stability in the presence of poly(ethylene glycol) (PEG) is investigated.
To show the versatility of reagent pencils, a novel reagent pencil incorporating a stimuli responsive polymer, poly(N-isporopylacrylamide) (PNIPAM) was developed. In this work, PNIPAM’s lower critical solution temperature (LCST) was manipulated with various salt solutions to control fluid flow both laterally and vertically through various microPAD designs. It was found that, while PNIPAM successfully blocked or retarded fluid flow in microPADs, the effect was limited when DI H2O wash solutions were run prior to salt solutions. To counteract this, PNIPAM was successfully covalently bound to alkene modified chromatography paper via thiolene click chemistry to reinforce solution wash tolerance.
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Castañeda, Lescano Diana Carolina del Carmen. "Participación de la enfermera comunitaria en la atención primaria de la salud. Microred Mórrope, 2017." Bachelor's thesis, Universidad Católica Santo Toribio de Mogrovejo, 2020. http://hdl.handle.net/20.500.12423/2594.
Повний текст джерелаАнотація:
Esta investigación es de tipo cualitativa y con abordaje metodológico de estudio de caso. Tiene como objetivo, identificar y analizar la participación de la enfermera comunitaria en la Atención Primaria de la Salud en la Microred Mórrope, con enfoque en la Atención Primaria de la Salud. Se sustentó con los autores: Participación (Muñoz, 1996), Enfermería Comunitaria (Roca, 2002) y Atención primaria de la salud (Alma-Ata, 1978). Los sujetos de estudio fueron 11 enfermeras que laboran en centros y puestos de salud del primer nivel de atención del ámbito de Microred Mórrope y la muestra se obtuvo utilizando los criterios de saturación y redundancia. Se utilizó como instrumento de recolección de datos la entrevista semiestructurada. En toda la investigación se tuvo en cuenta los criterios éticos y de rigor científico. Obteniendo como resultados: la participación de la enfermera en prevención y promoción de la salud y limitaciones de la enfermera para su participación en atención primaria de salud; y llegando a la consideración final general: La participación de la enfermera en cuanto a la prevención y promoción de la salud, es activa e integral. Activa, debido a que no sólo se intentan abordar a las familias cuando asisten a las postas médicas, sino que se complementa el trabajo asistiendo a sus domicilios y realizando charlas que no sólo abarcan al niño y al adulto mayor, sino que involucra a los adolescentes, madre, entre otros integrantes de la familia, convirtiéndose en un trabajo integral.Tesis
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Peralta, Guerrero Liseth Anali. "Nivel de actividad física en el adulto mayor de la Microred José Leonardo Ortiz, 2019." Bachelor's thesis, Universidad Católica Santo Toribio de Mogrovejo, 2020. http://hdl.handle.net/20.500.12423/2769.
Повний текст джерелаАнотація:
La población adulta mayor, se ha incrementado considerablemente y la práctica de actividad física en ellos es escasa, el sedentarismo es considerado el cuarto factor de riesgo para enfermedades no transmisibles, ante esta problemática se planteó el siguiente objetivo: determinar el nivel de actividad física en los adultos mayores que asisten al programa del adulto mayor de los establecimientos de salud de la Microred José Leonardo Ortiz, 2019. Estudio cuantitativo, descriptivo, de corte transversal, la población fue 303 adultos mayores, con una muestra de 178; distribuidos por muestreo estratificado en los seis establecimientos de salud de la Microred, fueron elegidos por muestreo por conveniencia. Se aplicó el cuestionario: actividad física del adulto mayor de Parraguez, instrumento validado por prueba binomial, y de confiabilidad con 0,6942 por Alpha de Cronbach. Este cuestionario evalúa la actividad física: doméstica, transporte y tiempo libre. Se tomó en cuenta los principios de rigor ético de Sgrecia.
Los resultados obtenidos mostraron que 77.5% son adultos mayores jóvenes, 60.7% sexo femenino, el 44.9% trabajan como ama de casa y el 65.7% no presentan comorbilidad crónica.
El 56.7% realizaron alto nivel de actividad física; con respecto a las actividades domésticas más del 50% manifestaron realizar trabajos livianos, pesados y preparar su comida; en relación al desplazamiento usan transporte público y realiza caminata, y con respecto a las actividades de tiempo libre 50.6% realizan actividades de recreación. Se concluye que los adultos mayores realizan un alto nivel de actividad física, tanto en actividad doméstica, transporte y tiempo libre.
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Kelk, Lisa. "Effect of Micronutrient Rate on the Growth of Containerized Quercus palustris Seddlings in Pine Bark." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/31073.
Повний текст джерелаАнотація:
The objectives for this research were to determine: 1) the rate of Micromax which will produce maximum growth of pin oak (Quercus palustris Munchh.), a landscape tree which has shown a previous growth response to the addition of Micromax at the manufacturer's recommended rate, 2) which micronutrient(s) is most associated with maximum growth, and 3) the rate of Cu, Fe, Mn, and Zn required to produce maximum growth of Quercus palustris. Q. palustris seedlings were container-grown in pine bark amended with the following rates of Micromax: 0, 0.15, 0.3, 0.6, 0.9, 1.8, or 2.7 kg(m-3 in 2000, 2001, and 2002. For all three years, the maximum growth was obtained at rates near the manufacturer's recommended rate of 0.9 kg(m-3. A micronutrient mix was formulated by increasing the levels of Zn, Mn, Fe, and Cu individually while holding the other micronutrients constant based on the grams of each micronutrient contained in Micromax at 0, 0.15, 0.3, 0.6, 0.9, 1.8, or 2.7 kg(m-3 for 2001 and 0, 0.45, 0.9, or 1.8 kg(m-3 for 2002. In addition, Cu, Fe, Mn, and Zn were also applied alone to pine bark at rates of 0, 0.45, 0.9, or 1.8 kg(m-3 without the addition of any other micronutrients. Holding all other micronutrients constant and increasing the rate of one micronutrient did not increase growth. However, when Cu, Fe, Mn, or Zn was added to pine bark alone at increasing rates, growth increased. For Cu and Zn, the growth increased was linear suggesting that a higher rate of Cu and Zn than that provided by Micromax at the manufacturer's recommended rate might be advantageous.Master of Science
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Kizhakke, Puliyakote Abhilash Srikumar. "Comprehensive assessment and characterization of pulmonary acinar morphometry using multi-resolution micro x-ray computed tomography." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/3120.
Повний текст джерелаАнотація:
The characterization of the normal pulmonary acinus is a necessary first step in understanding the nature of respiratory physiology and in assessing the etiology of pulmonary pathology. Murine models play a vital role in the advancement of current understanding of the dynamics of gas exchange, particle deposition and the manifestations of diseases such as COPD, Cystic Fibrosis and Asthma. With the advent of interior tomography techniques, high-resolution micro computed tomography (μCT) systems provide the ability to nondestructively assess the pulmonary acinus at micron and sub-micron resolutions. With the application of Systematic Uniform Random Sampling (SURS) principles applied to in-situ fixed, intact, ex-vivo lungs, we seek to characterize the structure of pulmonary acini in mice and study the variations across dimensions of age, location within the lung and strain phenotypes.
Lungs from mice of three common research strains were perfusion fixed in-situ, and imaged using a multi-resolution μCT system (Micro XCT 400, Zeiss Inc.). Using lower resolution whole lung images, SURS methods were used for identification of region-specific acini for high-resolution imaging. Acinar morphometric metrics included diameters, lengths and branching angles for each alveolar duct and total path lengths from entrance of the acinus to the terminal alveolar sacs. In addition, other metrics such as acinar volume, alveolar surface area and surface area/volume ratios were assessed.
A generation-based analysis demonstrated significant differences in acinar morphometry across young and old age groups and across the three strains. The method was successfully adapted to large animals and the data from one porcine specimen has been presented. The registration framework provides a direct technique to assess acinar deformations and provides critical physiological information about the state of alveolar ducts and individual alveoli at different phases of respiration.
The techniques presented here allow us to perform direct assessment of the three-dimensional structure of the pulmonary acinus in previously unavailable detail and present a unique technique for comprehensive quantitative analysis. The acinar morphometric parameters will help develop improved mathematical and near-anatomical models that can accurately represent the geometric structure of acini, leading to improved assessment of flow dynamics in the normal lung.