Дисертації з теми "Methodologic"
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Marchant, Natalie Lorraine. "Prospective memory : methodologic, pharmacologic, and genetic considerations." Thesis, University of Sussex, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508970.
Повний текст джерелаSmeets, Thomas Johannes Maria. "Immunohistochemical analysis of rheumatoid synovial tissue methodologic and pathogenetic studies /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/86863.
Повний текст джерелаCAMACHO, CRISTIANE FARIAS. "METHODOLOGIC FOR ASSESSMENT OF RURAL ELECTRIFICATION PROGRAM THROUGH MULTIVARIATE ANALYSIS." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2003. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=3716@1.
Повний текст джерелаA realidade vivida pela população rural tem sempre surpresas a revelar e mais ainda quando se trata do meio rural não eletrificado. Este estudo examina uma parte da realidade do cotidiano vivido por propriedades rurais envolvidas no Programa de Eletrificação Rural Luz no Campo, mostrando o modo de vida das propriedades na fase anterior ao recebimento de energia elétrica. Através do data mining dos dados coletados na pesquisa de campo do estado do Mato Grosso do Sul e da aplicação de técnicas de análise multivariada, tais como: Análise de Fatores e Análise de Cluster, este estudo possibilitará a visualização do modo de vida de propriedades não eletrificadas permitindo posteriormente a comparação com a chegada da energia elétrica que propiciará a avaliação do Programa de Eletrificação Rural. O modelo foi aplicado em dados de duas concessionárias de energia elétrica do Brasil usando dados horários coletados durante dois anos.
The reality lived by the rural population has always some surprises to reveal, even more when it's about the not electrified rural domain. This research examines a part of the reality lived by homestead involved in the Rural Electrification Program Luz no Campo, showing their way of life in the previous phase of the electricity receipt. Through the data mining of the collected data in the field research in Mato Grosso do Sul state and with the application a varied of statistical multivariate techniques such as: Factors Analysis and Cluster Analysis, this research will provide the visualization of the way of life of non electrified properties allowing a later comparison with the data collected in the same properties, after the arrival of the electricity. This way, it will be possible to establish a formal evaluation of the Rural Electrification Program.
Sanchez-Sweatman, Louise R. "The development of nursing cases for ethics research, a methodologic enquiry." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0005/MQ46125.pdf.
Повний текст джерелаKhachaturian, Ara S. "Methodologic studies for improved results in epidemologic research on the dementia of aging." Available to US Hopkins community, 2002. http://wwwlib.umi.com/dissertations/dlnow/3068174.
Повний текст джерелаMcGuire, Valerie. "Assessment of occupational exposures : methodologic issues in a risk factor study of amyotrophic lateral sclerosis /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/10855.
Повний текст джерелаKmetic, Andrew Martin. "Methodologic issues in the analysis of data from a population based osteoporosis study : adjusting for selection bias and measurement error." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84273.
Повний текст джерелаFor the first objective, Cantos had a relatively low participation rate (42%), so that selection bias is a concern. The Cantos study design, however, included a brief risk factor questionnaire for those invitees that declined further participation. These risk factors were then used to estimate the missing osteoporosis status for non-participants using Bayesian multiple imputation, thus adjusting for nonresponse bias. Both ignorable and non-ignorable imputation models are considered.
Complicating study of the relationship between the initial BMD and rate of decline is the issue of measurement error, which can cause a spurious negative association between the rate of change in a variable and the initial value of the variable. A novel variation on the Bayesian methods of Richardson and Gilks (1993b) is used to adjust for measurement error in both the initial and year three BMD values.
After adjusting for selection bias, prevalence increased from negligible in the youngest age group to 38.9% for women and 15.4% for men in the 80+ age group. Selection bias was estimated to be relatively small, except in the oldest age group, where the bias was 2.4% for women and 5.4% for men.
For women the unadjusted relationship between the rate of decline of BMD and initial BMD is negative, -0.040 (95% CI = -0.053; -0.028). Correcting for measurement error results in estimates closer to zero. For example, using a hierarchical model with measurement error correction yields an estimate of -0.030 (95% CI = -0.050; -0.009). For men the unadjusted relationship between rate of decline and initial BMD was -0.026 (95% CI = -0.043; -0.009). Correcting for measurement error using the hierarchical model yields a much lower estimate of -0.013 (95% CI = -0.041; 0.016). It is clear that ignoring measurement error results in a heavily biased estimate of the effect of initial BMD on rate of decline of BMD for both women and men. The measurement error adjusted estimates were of a lesser magnitude than the unadjusted estimate, with reductions of approximately 25% to 50%.
The results from this thesis can be used to make decisions about osteoporosis treatment in Canada. Knowledge of the prevalence rates in Canada is useful to public health planners in allocating resources. Knowledge of the relationship between initial levels of BMD and subsequent decline in BMD allows better public health decision making, for example, in deciding whether to focus on bone health early in life, or whether it is more important to prevent decline later in life.
Roemer, Frank W., Ali Guermazi, Jamie E. Collins, Elena Losina, Michael C. Nevitt, John A. Lynch, Jeffrey N. Katz, C. Kent Kwoh, Virginia B. Kraus, and David J. Hunter. "Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort − Methodologic aspects and definition of change." BIOMED CENTRAL LTD, 2016. http://hdl.handle.net/10150/623126.
Повний текст джерелаHajian-Tilaki, Karimollah. "Methodologic contributions to ROC analysis : a study of the robustness of the binormal model for quantitative data and methods for studies involving multiple signals." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29034.
Повний текст джерелаMetz et al (1990) adapted the binormal model, used previously for rating data only, for ROC analysis of quantitative diagnostic tests. Their investigation of its performance was limited to data generated from the bi-normal model itself. Part (i) of this thesis describes a broader numerical investigation to assess how it performs in various configurations of non-binormal pairs of distributions, where one or both pair members were mixtures of Gaussian (MG) distributions. We also investigated the effects of sample size and the number of data categories used. Three criteria, bias in estimates of the area under the curve (AUC), bias in estimated true positive fraction (TPF's) at specific false positive fraction (FPF) points, and discrepancies between the estimated and true TPF over the wider portion of the ROC curve, were used to assess the impact of departures from binormality. The bias in the estimates of AUC was small for all configurations studied, no matter what amount of discretization and what sample sizes were used. By the other criteria, the binormal model was robust to departures involving $ {$G, MG--skewed or bimodal$ }$ pairs. The fits were less appropriate at FPF = 0.05 and 0.10 when both pair-members were skewed to the right, but even then the bias in estimates of TPF was less than 0.06. The "semi-parametric" and nonparametric approaches yielded very similar estimates of AUC and of the corresponding sampling variability.
Part (ii) develops nonparametric ROC analysis for the situation when pathology and test interpretation data for each patient are K-dimensional. The approach computes K "pseudo-accuracies" for each patient; from these, K U-statistics are derived. One can form a summary index from these K components, as well as the standard error (SE) of this index based on the observed correlations among the pseudo-accuracies. The applicability of a simplified formula for the SE was assessed. The method was also extended to comparisons of two diagnostic systems. The procedures are illustrated using data sets from two clinical studies. The approach can handle the complex structure of multi-signal ROC data; it takes the various inter-correlations into account, and makes efficient use of the data.
Warren, Andrew Eugene. "The use of inhaled beclomethasone to decrease the duration of paroxysmal coughing in pediatric patients with pertussis, results and methodologic issues in a randomized clinical trial." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0003/MQ34238.pdf.
Повний текст джерелаWarren, Andrew Eugene. "The use of inhaled beclomethasone to decrease the duration of paroxysmal coughing in pediatric patients with pertussis : results and methodologic issues in a randomized clinical trial /." St. John's, NF : [s.n.], 1997.
Знайти повний текст джерелаKruse, Lance M. "Item-Reduction Methodologies for Complex Educational Assessments: A Comparative Methodological Exploration." University of Toledo / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1576175496892792.
Повний текст джерелаFons?ca, Alexandre V?tor de Lima. "Orienta??o geogr?fica: uma proposta metodol?gica para o ensino da geografia na 5? s?rie." Universidade Federal do Rio Grande do Norte, 2004. http://repositorio.ufrn.br:8080/jspui/handle/123456789/18971.
Повний текст джерелаCoordena??o de Aperfei?oamento de Pessoal de N?vel Superior
Cartographical representations (maps, charters and plans) are taken as didactic resources in Geography classes in the 5th grade of the municipal public schools in S?o Jos? de Ribamar through a methodological approach taking into consideration the use of those resources is still worries an important part of the teachers of the Maranh?o State public schools who teach in this level. Papers related to the theme, most of the time, are non accessible to the teachers of the maranhense public schools, mainly because the education instilutions, which use those resources, do it in a very incipient way. So this research proposes from the drawings of magnetccoursein the school courtyards, together with maps, charts, plans among others representation used in the classroom environment, motivate the students to a deeper interests in participating in Geography learning process in the 5th grade. Interviews, analyses of socialcultural questionnaires of the families involved in the process; observations of classes, trainings, geocartographical orientations, application of pre and posttests, discussions about the usage of cartographic representations, proposed and effectivated tasks in the classroom, as well as around the school, were the basis of the researched population. As a result of this process, it was produced a was complement didatical material showing, among others, the space in which students, for sure, will contribute in an effective way to a better teaching practice in the chain of maranhense public schools, having in mind that these geographic subjects may be taught in the level we focused our study
Abordase o uso das representa??es cartogr?ficas (mapas, cartas e plantas) como recursos did?ticos nas aulas de Geografia na 5? s?rie da rede p?blica municipal de S?o Jos? de Ribamar, a partir de uma proposta metodol?gica, onde, o uso desses recursos ainda ? motivo de preocupa??o para uma parcela consider?vel de educadores que ministram aulas no ensino fundamental. Trabalhos a respeito do tema, na maioria das vezes, s?o inacess?veis aos professores da rede p?blica maranhense, principalmente tendo em vista que as institui??es de ensino que fazem uso desse recurso, ainda o fazem de forma incipiente. Assim sendo, a pesquisa prop?e, a partir do desenho derumosmagn?ticosnos p?tios escolares, em conjunto com mapas, cartas, plantas, entre outras representa??es utilizadas na sala de aula, despertar em educandos, um maior interesse em participar do processo de aprendizagem nas aulas de Geografia da 5? s?rie. Entrevistas; an?lises de question?rios s?cioculturais das fam?lias envolvidas no processo; observa??o de aulas; treinamentos; orienta??es geocartogr?ficas; aplica??o de pr? e p?stestes, discuss?es a respeito do uso de representa??es cartogr?ficas, tarefas propostas e efetivadas nas salas de aulas e em torno das escolas, embasaram e envolveram todo o universo amostral pesquisado. Como resultante desse processo, foi produzido material did?tico complementar retratando o espa?o vivenciado pelos educandos, que, certamente, contribuir?, de forma efetiva, para a melhoria da pr?tica docente nas escolas da rede p?blica maranhense, na medida em que os conte?dos geogr?ficos da referida s?rie forem ministrados
Fitzgerald, Brian. "Methodology-in-action : the nature of usage of systems development methodologies in practice." Thesis, Birkbeck (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265004.
Повний текст джерелаClark, J. V. W. "Reclaiming novelty : Hannah Arendt on natality as an anti-methodological methodology for sociology." Thesis, University of Essex, 2018. http://repository.essex.ac.uk/22373/.
Повний текст джерелаEpiskopou, D. M. "The theory and practice of information systems methodologies : A grounded theory of methodological evolution." Thesis, University of East Anglia, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380960.
Повний текст джерелаAndersson, Victor. "Standards and methodologies for evaluating digital forensics tools : Developing and testing a new methodology." Thesis, Högskolan i Halmstad, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-37485.
Повний текст джерелаAbdallah, Salam. "Unravelling methodologies: a theory building approach." Thesis, Curtin University, 2005. http://hdl.handle.net/20.500.11937/287.
Повний текст джерелаTabrez, Shams, and Islam Jan. "Documentation and Agile Methodology." Thesis, Uppsala universitet, Institutionen för informatik och media, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-212653.
Повний текст джерелаAzam, Zaher. "WEB PROJECTS MANAGEMENTBETWEEN THEORY & PRACTICAL APPLICATION." Thesis, Tekniska Högskolan, Högskolan i Jönköping, JTH. Forskningsområde Informationsteknik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-14318.
Повний текст джерелаAbimbola, Kolapo Ogunniyi. "Scientific rationality and methodological change : a critical examination of some recent attempts to naturalize methodology." Thesis, London School of Economics and Political Science (University of London), 1994. http://etheses.lse.ac.uk/1228/.
Повний текст джерелаAbdallah, Salam. "Unravelling methodologies: a theory building approach." Curtin University of Technology, School of Information Systems, 2005. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=16417.
Повний текст джерелаTaylor, Martin Allen. "The use of systems development methodologies in web-based application development in South Africa / Martin Allen Taylor." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1447.
Повний текст джерелаDias, Luiz Jorge Bezerra da Silva. "PROPOSTA METODOLÓGICA DE ZONEAMENTO AMBIENTAL APLICADA AO MUNICÍPIO DE ANAJATUBA (MA)." Universidade Federal do Maranhão, 2006. http://tedebc.ufma.br:8080/jspui/handle/tede/1216.
Повний текст джерелаCoordenação de Aperfeiçoamento de Pessoal de Nível Superior
The Area of Environmental Protection of the Baixada Maranhense is one of the poorest areas economically of the State of Maranhão (Brazil) and lacking with respect to the readiness of information on the municipal districts that compose her. That implicates in a lack of appropriate theoretical-methodological orientation to the perspectives of environmental plannings and of establishment and execution of public politics gone back to the improvement of the conditions of the inhabitants' life. In that sense, a methodological proposal of Environmental Zoning was elaborated applied to the municipal district of Anajatuba (MA), because that space represents a mosaic of the situations physical, ecological and social (in all the senses) of the regional domain in that he/she interferes. They grew recognition studies and of classification of the elements / physical environmental resources (geology, geomorphology), geoecology(typologies of ecosystems) and humans (population evolution). That approach was complemented by the elaboration of the swinging municipal hidrological, which is considered important for sending to the readiness of the waters, in their several compartments, destined to the human provisioning and maintenance of their activities. The crossing of those information indicates which should be the appropriate sustainability strategies for the municipal district.
A Área de Proteção Ambiental da Baixada Maranhense é uma das regiões mais pobres economicamente do Estado do Maranhão (Brasil) e carente no que tange à disponibilidade de informações sobre os municípios que a compõem. Isso implica numa falta de orientação teórico-metodológica adequada às perspectivas de planejamentos ambientais e de estabelecimento e execução de políticas públicas voltadas para a melhoria das condições de vida dos habitantes. Nesse sentido, elaborou-se uma proposta metodológica de Zoneamento Ambiental aplicada ao município de Anajatuba (MA), pois esse espaço representa um mosaico das situações físicas, ecológicas e sociais (em todos os sentidos) do domínio regional em que se insere. Desenvolveram-se estudos de reconhecimento e de classificação dos elementos/recursos ambientais físicos (geologia, geomorfologia), ecogeográficos (tipologias de ecossistemas) e humanos (evolução populacional). Essa abordagem foi complementada pela elaboração do balanço hídrico municipal, o qual é considerado importante por remeter-se à disponibilidade das águas, em seus diversos compartimentos, destinadas ao abastecimento humano e manutenção de suas atividades. O cruzamento dessas informações indica quais devem ser as estratégias de sustentabilidade adequadas para o município.
Farahini, Nasim. "SiLago: Enabling System Level Automation Methodology to Design Custom High-Performance Computing Platforms : Toward Next Generation Hardware Synthesis Methodologies." Doctoral thesis, KTH, Elektronik och Inbyggda System, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-185787.
Повний текст джерелаLucas, Paul Mark. "Secondary Science Homework and Instructional Methodologies: An Investigation of the Alignment of Homework Assignments and Teachers' Self-Professed Instructional Methodology." Ashland University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ashland1251379408.
Повний текст джерелаSibeoni, Jordan. "L’apport des méthodes qualitatives dans la recherche sur les soins en psychiatrie de l’adolescent." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS425/document.
Повний текст джерелаQualitative methods aim to describe, understand and deepen an observed phenomenon. Our objectives are both methodological and therapeutic. We illustrate the contribution of qualitative methods in research from three qualitative studies. These studies will jointly explore the issue of care and especially the perception of psychiatric care from adolescents, their families and caregivers. The first study is a metasynthesis - systematic review and analysis of qualitative literature- on anorexia nervosa in adolescence. The second study will focus on the use of the photographic tool and its effectiveness in qualitative research in adolescent psychiatry. This qualitative study will explore the functioning and family interactions around food and meals using Photo-elicitation. Finally, the third qualitative research will explore the perceived efficacy of care among adolescents receiving a treatment for school refusal, and their parents. These three studies enable us to discuss the contribution of qualitative methods in adolescent psychiatry care research and also the need of developing such methods in the field of clinical research in public health
FOURNIER, HUGOT SONIA. "La methodologie freudienne." Lille 3, 1987. http://www.theses.fr/1987LIL30011.
Повний текст джерелаHottinger, Stephan. "Nelson Goodmans Methodologie /." [Bern] : Selbstverlag, 1985. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Повний текст джерелаTsai, Shi-Chi. "Using data mining to explore the regularity of genetic algorithms in job shop schedule problems." Ohio : Ohio University, 1997. http://www.ohiolink.edu/etd/view.cgi?ohiou1184347015.
Повний текст джерелаPieterse, Petronella Johanna. "An interpretive analysis of systems development methodology adaptation in South Africa / P.J. Pieterse." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1565.
Повний текст джерелаNovy, Andreas. "Die Methodologie interpretativer Sozialforschung." Institut für Wirtschaftsgeographie, Abt. Stadt- und Regionalentwicklung, WU Vienna University of Economics and Business, 2002. http://epub.wu.ac.at/1444/1/document.pdf.
Повний текст джерелаKeskin, Emre. "Methodological Physicalism." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12608155/index.pdf.
Повний текст джерелаChomsky'
s challenge to materialism&rdquo
by claiming that with the abolishment of the definition of the matter, there is no reason to defend materialism, which depends on that definition. Therefore, materialism becomes an empty doctrine thus cannot be used in explaining the mind. The developments in the modern physics creates the need for a new doctrine, which can explain the mind and at the same time be compatible with the modern physics and possible any future physics. This new doctrine, the methodological physicalism, aims to explain the mind by using the modern physics. Creating such a doctrine requires understanding of materialism and its form as well as understanding the problems of materialism and its forms. By identifying the defects in materialism and by using the modern physics as a standing point methodological physicalism can achieve a more successful understanding of the working of the mind. By using the modern physics, the methodological physicalism can explain why the currents models of the mind fail. Moreover, it can explain how certain models of the mind constructed, which employs the quantum mechanics while explaining the mind. The methodological physicalism will help understanding the mind where materialism fails to do so.
Anette, Lindskog. "Methodology evaluation." Thesis, Linnéuniversitetet, Institutionen för informatik (IK), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-71276.
Повний текст джерелаKolář, Vít. "Implementace metodiky budování IS v IT společnosti." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-19061.
Повний текст джерелаGroux-Leclet, Dominique. "Une approche par plans et par modélisation du domaine appliquée à l'enseignement de la rhumatologie : le système ARIADE : Apprentissage de la Rhumatologie Intelligemment Assistée par orDinatEur." Compiègne, 1993. http://www.theses.fr/1993COMP666S.
Повний текст джерелаSlouma, Maher. "Vers une approche incrémentale et contingente de la communication des connaissances : le cas du Knowledge Management." Thesis, Toulon, 2015. http://www.theses.fr/2015TOUL0005.
Повний текст джерелаIn an economy founded on the knowledge and the data, the mastery of informational resources became one of the main factors of success and competitiveness of all innovating organization. It is what explains the important investment on the subject on behalf of all economic actors. In this context, the Knowledge Management appears like an answer permitting to organize and to master the knowledge and expertise’s acquired in intern to act in external. The knowledge management has for goal to have a lasting information system and an informational dynamics within the organizations. Our topic drove us to a long observation of the preoccupations of the actors of the community Knowledge Management. We studied their main questionings in the different channels of communication; we regrouped their waiting thereafter in two big questions that constitute our questions of research indeed. This research aims to reach two main objectives : The 1st objective is to understand how to put a gait Knowledge Management in place in an organization and to know if this gait is the same for any type of organization. Otherwise what the factors of contingency are to take in consideration? The 2nd objective: once this gait setting up, is. her evolutive, changing and incremental or she remain static? These two objectives constitute the two main parts that we treat in this thesis. To answer this problematic, we chose to use a methodological pluralism leaning on the one hand on methods of informational intelligence, on the other hand on a quantitative survey with the help of a questionnaire and finally on a qualitative survey via interviews
BARBEAU, SYLVAIN. "Methodologie d'ingenierie des systemes aerospatiale." Nantes, 1997. http://www.theses.fr/1997NANT2069.
Повний текст джерелаCudjoe, Samuel. "How do Companies Reward their Employees." Thesis, KTH, Industriell ekonomi och organisation (Avd.), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-102749.
Повний текст джерелаNewman, Janson. "QS Ranking Methodologies." Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/623345.
Повний текст джерелаConferencia acerca de la importancia de los rankings universitarios: caso QS World University Rankings.
Keeler, Rebecca L., Aaron Wachhaus, Bob Cunningham, Tom Barth, Richard Huff, and Michael Howell-Maroney. "David Farmer: Methodologist?" Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/651.
Повний текст джерелаGómez-Valent, Mònica. "Proposal for a new classification of orphan and/or rare conditions based on clinical characteristics that determine the applicability of different research methods to their study." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/405590.
Повний текст джерелаBackground: Rare diseases are those that affect a small number of people and have a particularly low prevalence compared to the general population. While individually these entities are uncommon, as a group they are an important cause of chronic illness, disability and premature death in both children and adults. The European Union considers diseases to be rare when they affect not more than 5 in 10000 individuals. Methodologies aimed to increase efficiency of clinical studies in small populations have been only scarcely applied to the clinical development of new orphan medicinal products (OMP). The lack of references and guidance may explain reluctance to alternative methodologies, but specific guidance is impractical due to the huge number of existing orphan conditions. A systematic approach to grouping medical conditions based on their methodological requirements may be useful to allow generalisation of recommendations to type conditions, rather than to single disease models. Hypothesis: Orphan conditions can be grouped through a systematic approach based on their methodological requirements, and the resulting clustering can be an effective tool for establishing specific recommendations for the study of groups of conditions rather than for individual conditions, that would facilitate a more structured approach to regulatory development and decision making. Objective: To propose a clustering of medical conditions based on their methodological requirements, with the aim to provide a framework for guidance on treatment development and regulatory decision making on OMP. Methods: The characteristics of medical conditions which may be relevant to study design and regulatory decision making have been identified, and a number of sample conditions have been described in detail for these characteristics and used to produce a database that has been analysed through Multiple Correspondence Analysis (MCA) to identify clusters of conditions. These have been refined and validated from a clinical and regulatory perspective which included a meeting with clinical specialists with recognised expertise in the field of orphan diseases, in order to know their opinion towards the proposed classification and to get insights on potential weaknesses of the approach. Results: Six groups of medical conditions are proposed which share applicability of similar methodologies to their study: single acute episode, repeated acute episodes, slow/non progressive, progressive led by one organ or system, progressive multidimensional multi-organ and staged condition. A total of 125 medical indications with positive opinions issued by the EMA on OMP applications have been clustered to test applicability of inferences. The methodological inferences to the different established clusters implied a first step of listing the variables that had a high discriminative value for each cluster, and a second step to make detailed descriptions of these determinants in relation to aspects required to define clinical study designs. This was done in order to test the validity of the proposed clusters to their main purpose as issuing common recommendations on product development for a given group of conditions. The results of the surveys given to members of the clinical board were collected and summarised. Clinicians agreed on the fact that current methods in clinical research have room for a more structured approach and that would help to the access to new treatments urgently needed, and considered it would be useful to guide methodological decision for industry and regulators, also to investigators and health technology assessment. Conclusions: A new clustering of conditions based on their methodological requirements is proposed as a framework for guidance on treatment development and regulatory decision making on OMP.
Ullrich, Peter. "Moralischer Kompatibilismus : zur Methodologie der Metaethik /." Würzburg : Ergon, 2008. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=016391778&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA.
Повний текст джерелаÖhrblad, Henrik, and Henrik Berglund. "Component Meshing Methodology." Thesis, Linköping University, Department of Management and Engineering, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-10683.
Повний текст джерелаIn order to achieve results that are reliable when using the finite element method one has to use an acceptable element mesh with respect to the shape and size of the elements. As a help to produce an acceptable mesh there are quality criteria that must be fulfilled in most pre-processors.
One objective with this thesis is to perform a sensitivity study that can be used as a basis for a Mesh guideline for chassis parts which is requested from engineers at Volvo 3P. The software used in the sensitivity study is ANSA as pre-processor, Nastran as solver and Metapost as post-processor.
In the first part of the sensitivity study three different models are used for studying quality criteria such as aspect ratio, skewness, mid point alignment, mid point deviation and element size. Solid elements of second order, which are used in the three models, can be generated in two ways, which constitutes another part of the sensitivity study. They may either be generated from the beginning or can be converted from first order elements. This means geometrically that if second order elements where generated from the beginning the element mesh would follow the shape of the component in a better way compared to the other method.
Recently a pre- and post-processing program called SimLab was introduced on the market. Since SimLab supports geometry import from several CAD-systems without loss of feature information, the automatic element mesh generation is supposed to be better as the mesh generator has access to more information concerning the geometry. An evaluation of SimLab is the second major objective of the thesis. More specifically, the evaluation concerns the possibility of using the software at Volvo 3P.
Results show a surprising insensitivity regarding the criteria and that the method of generating second order elements from the beginning is to be preferred. SimLab is a new program with big potential and the conclusion is that it is possible to use it at Volvo 3P.
Thomas, Emmanuelle Maitrise de Chimie. "Electrophilic fluorination methodology." Thesis, Durham University, 2002. http://etheses.dur.ac.uk/4151/.
Повний текст джерелаBailey, J. B. "Law teaching methodology." Thesis, Manchester Metropolitan University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355850.
Повний текст джерелаMhar, Javeed I. "VLSI design methodology." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/11855.
Повний текст джерелаDietrich, Jens. "Nutzung von Modellierungssprachen und -methodologien standardisierter B2B-Architekturen für die Integration unternehmensinterner Geschäftsprozesse : Evaluierung des Einsatzes der UN/CEFACT Modeling Methodology (UMM) bei einer deutschen Kapitalanlagegesellschaft /." Berlin : GITO-Verl, 2008. http://deposit.d-nb.de/cgi-bin/dokserv?id=3062793&prov=M&dok_var=1&dok_ext=htm.
Повний текст джерелаDietrich, Jens. "Nutzung von Modellierungssprachen und -methodologien standardisierter B2B-Architekturen für die Integration unternehmensinterner Geschäftsprozesse Evaluierung des Einsatzes der UN/CEFACT Modeling Methodology (UMM) bei einer deutschen Kapitalanlagegesellschaft." Berlin GITO-Verl, 2007. http://deposit.d-nb.de/cgi-bin/dokserv?id=3062793&prov=M&dok_var=1&dok_ext=htm.
Повний текст джерелаLin, Cheng C. "On the combination of operational research methodology and soft systems methodology." Thesis, Lancaster University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304427.
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