Дисертації з теми "Méthodes de production"
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Chevalier, Milhe Nathalie. "Ordonnancement d'un système de production : méthodes de voisinage." Montpellier 2, 1994. http://www.theses.fr/1994MON20052.
Liess, Olivier. "Méthodes de décomposition non standard et applications." Avignon, 2006. http://www.theses.fr/2006AVIG0145.
Oger, Julie. "Méthodes probabilistes pour l'évaluation de risques en production industrielle." Phd thesis, Université François Rabelais - Tours, 2014. http://tel.archives-ouvertes.fr/tel-00982740.
Korolev, Alexei. "Stratégie de production des molécules marquées par de méthodes biologiques." Aix-Marseille 3, 1995. http://www.theses.fr/1995AIX30038.
The nucleotids containing the radioactive tracers in the isotop form 32P, 33P or 35S hold an important place in market of the labelled compounds. In regard to the technology developpment model proposed by the Managementlaboratory for industrial projects, we have elaborated and applied the news synthesis methodes for these compounds which pennit their production industrially (hundreds of mCi). In the first part of this thesis we have analysed the paths for the nucleotide biosynthesis " in vivo " and the enzymes which participate in the biosynthesis. The optimisation of the enzyme concentrations in the Johnson-Walseth [112, 235, 236] method which increased the yields and the quantitys of the synthetized products. The introduction of the triose-phosphate isomerase (EC 5. 3. 1. 1) in the schema using the FDP created a regeneration circuit of D-glyceraldehyd-3-phosphate from DHAP which increased the production and the efficiency of the transformation. The elaboration of the new synthetic shemas based on transaldolases or transcetolases (EC classe 2. 2. 1. X) resulted in the creation of production methods protected by the patent (deposit). The optimisation of the HPLC purifications in the reversed phase helped us to lower considerably the number of operations necessary in order to obtain the final product. .
Lacomme, Philippe. "Optimisation des systèmes de production : méthodes stochastiques et approche multi-agents." Clermont-Ferrand 2, 1998. http://www.theses.fr/1998CLF21986.
Siebert, Nils. "Développement de méthodes pour la prédiction de la production éolienne régionale." Phd thesis, École Nationale Supérieure des Mines de Paris, 2008. http://tel.archives-ouvertes.fr/tel-00287551.
Le but de la thèse est de développer un cadre d'analyse et des outils permettant de faciliter la mise en place de modèles de prévision de la production éolienne régionale.
La thèse présente tout d'abord un cadre d'analyse permettant de caractériser la production éolienne régionale. Par ce biais, les propriétés saillantes de la production régionale, qui doivent être prises en compte lors de la conception d'un modèle de prévision régionale, sont identifiées.
Le problème de la prévision régionale est ensuite abordé comme un problème d'apprentissage statistique. Nous définissons trois approches de modélisation générique permettant la combinaison de sous-modèles. L'influence de ces approches sur la précision des prévisions est étudiée ainsi que celle du choix des sous-modèles. Pour permettre la comparaison de sous-modèles, nous introduisons un modèle de prévision éolienne dont la performance est comparable aux modèles de l'état de l'art.
Finalement, nous examinons l'impact sur la précision de prévision qu'a le choix des variables explicatives et nous proposons des règles générales de sélection dans le cadre de la prévision éolienne régionale. Pour faciliter le processus de modélisation, des méthodes de sélection automatique sont étudiées. Deux méthodes (une méthode filtre et une méthode wrapper) qui exploitent les caractéristiques propres au problème sont proposées. Nous montrons que ces méthodes sont plus performantes qu'une méthode générique de l'état de l'art.
Siebert, Nils Walter. "Développement de méthodes pour la prédiction de la production éolienne régionale." Paris, ENMP, 2008. http://tel.archives-ouvertes.fr/tel-00287551.
The large-scale integration of wind power can be a challenge for power system operators because, unlike conventional power sources, wind power is variable and non-dispatchable. To alleviate some of the problems posed by large-scale wind power integration, power system operators express the need for short-term (48 to 120 hours ahead) forecasts of the aggregated output of all wind farms within a specified geographical region. The aim of the thesis is to develop a framework and tools to help in the implementation of statistical regional wind power forecasting models. We first propose a framework for the characterization of the regional wind power. In this way, salient aspects of the regional wind power forecasting problem that must be taken into account when designing a regional forecasting model are identified. We then examine the regional forecasting problem from a statistical learning perspective. We define three generic approaches that can be used to combine sub-models to build regional models. The influence of these approaches on forecast accuracy is examined, as well as that of the choice of sub-models. The comparison of sub-models is made possible by the introduction of a novel forecasting model whose performance is shown to be comparable to that of other state-of-the-art models. Finally, we examine the impact of explanatory variable selection on forecast accuracy and derive general guidelines applicable in the frame of regional wind power forecasting. To ease modelling, automatic selection techniques are investigated. Two variable selection methods (a filter and a wrapper method) that exploit problem-specific characteristics are proposed. These methods are shown to compare very favourably to a generic state-of-the-art method
Hail, Nourredine. "Méthodes algorithmiques pour les lignes de production avec des machines parallèles." Université Joseph Fourier (Grenoble), 1995. http://www.theses.fr/1995GRE10019.
Bloch, Gérard. "Modélisation des procédés : Des méthodes, un outil logiciel." Nancy 1, 1988. http://www.theses.fr/1988NAN10343.
Schamper, Cyril. "Etude par simulation du suivi d'un réservoir en production par méthodes ElectroMagnétiques." Paris 6, 2009. http://www.theses.fr/2009PA066608.
Low frequency electromagnetic methods from a controlled source (CSEM : Controlled Cource ElectroMagnetic) have been applied for a little more than a decade in oil exploration. As a complement to seismic methods, they permit lowering of the risk of «dry holes», since they are more sensitive to the nature of the uid contained in rock. Because of the numerous successes encountered, and experience acquired, petroleum companies foresee extending application of CSEM to the monitoring of reservoirs under production. The principal problems are monitoring the oil-water interface to avoid loss of production due to invasion by water, and to estimate the e_ciency of improved techniques on the recovery rate for production (EOR : Enhanced Oil Recovery). The interface of oil and water is subject to an essentially lateral displacement due of low thickness of hydrocarbon reservoirs having an area that exceeds several square kilometres. The work of this thesis, done in partnership between UPMC and CGG Veritas, consists of the theoretical feasibility of monitoring CSEM for the lateral displacement of oil-water interface with a n apparatus that permits obtaining information on the distribution of uids for a large surface reservoir. We are particularly interested in the land milieu. After an examination of the status of applied geophysical methods on the monitoring for hydrocarbon reservoirs, a presentation of the theory of simulation algorithms is made. For this thesis, two codes have been developed, parallelized and used on parallel machines for which the calculation grid is European, EGEE. The _rst uses the semi-analytic Method of Moments for the frequency domain, and by extension, for the time domain. The second is based on _nite di_erence for the time domain. The development is more concentrated on the Method of Moments (code : EM MOM). The EM MOM code was able to be tested during a cooperative mission with CIPR (Center for Integrated Petroleum Research) at the University of Bergen, Norway. The code permitted doing a sensitivity analysis in the frequency domain to identify device geometries better adapted to the monitoring of a hydrocarbon reservoir (depth of 1000 meters). The apparatus that yields the greatest sensitivity consists of a vertical dipole source buried at mid depth between the top of the reservoir and the ground surface, and of horizontal receptors for electrical _eld set on the ground surface. The level of 4D signal, i. E. , the di_erence of measured _eld at two di_erent instants («time lapse») remains at a level slightly over the ambient noise, which can largely be eliminated by summation (vertical stacking). A series of measures of ambient noise done by CGGVeritas, presented in the _rst part of this thesis, establishes this observation. A 4D inversion algorithm has demonstrated the possibility of interpreting the synthetic CSEM data by using a single position of source, and an array of receivers positioned on the surface. The images drawn from the inversion trials show the oil-water interface very well. The neglect of a narrow layer of a dozen meters having a strong contrast in conductivity with the terrain environment, is practically annulled for the signal measured at the surface, but reduces the resolution of the oil-water boundary in 4D inversion. A high level of knowledge of the distribution of electrical conductivity for the entire terrain environment is therefore necessary for the inversion of 4D CSEM data. Iv
Djellab, Housni. "Optimisation combinatoire dans les systèmes de production : hypergraphes et méthodes d'amélioration itératives." Clermont-Ferrand 2, 1997. http://www.theses.fr/1997CLF21952.
Claisse, Maxime. "Méthodes de pilotage des flux avec prise : en compte des incertitudes prévisionnelles." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLC022/document.
Production Planning, as part of tactical operations integrated into the Supply Chain process, is a key procedure allowing decisioners to balance demand and production resources. One of its most challenging issues is to handle uncertainties, especially the ones coming from the Forecasted Demand. In order to manage indicators at stake, such as service level and costs, best practices increasing flexibility in the process are implemented, as Rolling-Plan Framework. However, it creates instability since the updates procedures make the data set on change constantly. Consequently, although the gain in terms of flexibility is non-negligible for the uncertainties management, it generates on the other hand dynamics complexity. We study in this work how to deal this dynamics complexity generated by updates of the Forecasted Demand made in a Rolling-Plan Framework of a Production Planning Process. In particular, the question to which it answers is how to optimize the Production Plan in such a context. This issue is tackled considering a single item single level production system. A general mathematical model in the context of our study is built to be exploitable for analytical optimization. A theoretical optimization framework is designed, and a specific solutions computation framework using stochastic dynamic programming is developed. We apply it in some precise study cases in order to compute optimal solutions and get some valuable analytical results thanks to a dynamic computation process. The optimality of the solutions is proven through an inductive reasoning based on expectations computation. Solutions are finally implemented and calculated numerically with simulations in some particular numerical examples. Analyses and sensitivity studies are performed, highlighting the performances of our optimization method
Kassou, Ismaïl. "Amélioration d'ordonnancements par des méthodes de voisinage." Rouen, 1992. http://www.theses.fr/1992ROUES025.
Rebaï, Ismaïl. "Méthodes exactes et heuristiques pour le flow-shop de permutation." Châtenay-Malabry, Ecole centrale de Paris, 1996. http://www.theses.fr/1996ECAPA001.
Campos, Ciro Guillermo. "Développement de méthodes d'ordonnancement efficaces et appliquées dans un système de production mécanique." Thesis, Troyes, 2015. http://www.theses.fr/2015TROY0035/document.
The continuous evolution of manufacturing environments and the growing of customer needings, leads to a faster and more efficient production process that controls an increasing number of parameters. This thesis is focused on the development of decision making methods in order to improve the production scheduling. The industrial partner (Norelem) produces standardized mechanical elements, so many different resource constraints (humans and tools) are presented in its workshop.We study an open shop scheduling problem where one job can follow multiple production sequences because there is no fixed production sequence and the objective function is to minimize the total flow time. In addition, multi-skilled personnel assignment and tool’s availability constraints are involved.Mathematical models: linear and non-linear formulations have been developed to describe the problem. Knowing the exact method limitations in terms of instance sizes because of the duration, heuristics methods have been proposed and compared. Besides that, the multi-objective optimization was exposed to deal with three objectives as total flow time minimization and workload balancing concerning both, humans and machines.The efficiency of these methods was proved by several theoretical instance tests and the application on the real industrial case
Eyl, Véronique. "Études métaboliques et physiologiques d'hybridomes murins : comparaison entre différentes méthodes de production d'anticorps." Nancy 1, 1991. http://www.theses.fr/1991NAN10438.
Haouet, Chaker. "Méthodes de "production à la japonaise" et implications pour le contrôle de gestion." Paris 1, 1993. http://www.theses.fr/1993PA010027.
This study "methods of production japanese style and implications for management control" , is an empirical research project whose primary goal is to contribute to an understanding of management control practices within the particular organizational context of "just in time" production. The study has three main objectives: 1- to examine the practices of management control employed in industrial establishments engaged in methods of "japanese style" or "just in time" production; 2- to attempt to appreciate and to explain the degree of evolution of industrial management control due to the utilizati partial or complete, of a "just in time" production organization; 3- to trace the possible future evolution of management control within this context. We have deemed it useful to our readers to begin with a description of "japanese style" methods of production, followed by an overview of the conventionally accepted principles which govern management control practices. After an indepth investigation of the relation between management control and "just in time" production as they occur in 28 systems of productional organization within industrial enterprises from various sectors of activity, we have analysed the results and attempted to posit some possible conclusions. The results of our study led us most notably to identify the variables permitting us to evaluate the degree of advancement of establishments in the adaptive installatio their management control applications, as well as to troubleshoot and clearly delineate the complications of disfunction applications. The final and concluding chapter advances the bases of principles of management control induced by the adoption of "japanese style production"
Trouillet, Benoît. "Sur l'évaluation du comportement logique des systèmes de production manufacturière par méthodes exactes." Lille 1, 2003. http://www.theses.fr/2003LIL10021.
L'obtention d'un graphe d'événements permet d'envisager une approche algébrique du comportement logique du SFPM en considérant un marquage initial quelconque. Dans le cas d'une étude d'un graphe d'événements pondéré, la présence de poids sur les arcs induit l'utilisation de l'opérateur div correspondant à la division euclidienne. Ainsi, une abstraction du comportement logique conduit à un système d'équations non-linéaire au sens du dioïde (min,+). Ce qui justifie l'étude d'une méthode de linéarisation permettant l'expression du comportement logique à l'aide d'un système d'équation linéaire. Pour une classe de réseaux de Pétri, un algorithme de linéarisation est proposé. Par conséquent, l'ensemble des séquencements possibles des opérations du modèle intial, avec le respect des contraintes de fonctionnement, correspond à l'ensemble des solutions du système d'équations linéaires obtenu. Le comportement logique du réseau de Pétri initial peut être étudié sur un horizon (nombre de steps) quelconque, dont le résultat correspond aux séquences de franchissements engendrant un comportement cyclique d'horizon prédéfini. Dans ce cadre l'évaluation des performances des solutions obtenues peut être effectuée à priori
Tran, Duc Quynh. "Optimisation non convexe en finance et en gestion de production : modèles et méthodes." Thesis, Metz, 2011. http://www.theses.fr/2011METZ019S/document.
This thesis deals with optimization techniques for solving some optimization problems in two domains : portfolio selection and production management. They are large scale non convex optimization problems due to integer variables and/or the non convexity of the objective function. Our approach is based on DC programming and DCA, DC relaxation techniques and the algorithm Branch and Bound. This work is motivated by the robustness and the performance of the DC programming and DCA compared to other methods. The thesis includes three parts : In the first part, we present the fundamental tools and the essential techniques in DC programming, DCA as well as the method Branch and Bound. The second one concerns some non convex optimization problem in portfolio selection. Two following problems are considered : Min max continuous problem with the cardinality constraints in portfolio selection ; A class of bilevel programming problems and its application in portfolio selection. The third part contains some non convex optimization problems in production management. We study three problems : Minimization of the maintenance cost involving the flow time and the tardiness penalty ; Minimization of the cost of multi-stages production/inventory systems with bottleneck ; Determination of transfer prices and inventory policy in supply chain of two enterprises
Tran, Duc Quynh. "Optimisation non convexe en finance et en gestion de production : modèles et méthodes." Electronic Thesis or Diss., Metz, 2011. http://www.theses.fr/2011METZ019S.
This thesis deals with optimization techniques for solving some optimization problems in two domains : portfolio selection and production management. They are large scale non convex optimization problems due to integer variables and/or the non convexity of the objective function. Our approach is based on DC programming and DCA, DC relaxation techniques and the algorithm Branch and Bound. This work is motivated by the robustness and the performance of the DC programming and DCA compared to other methods. The thesis includes three parts : In the first part, we present the fundamental tools and the essential techniques in DC programming, DCA as well as the method Branch and Bound. The second one concerns some non convex optimization problem in portfolio selection. Two following problems are considered : Min max continuous problem with the cardinality constraints in portfolio selection ; A class of bilevel programming problems and its application in portfolio selection. The third part contains some non convex optimization problems in production management. We study three problems : Minimization of the maintenance cost involving the flow time and the tardiness penalty ; Minimization of the cost of multi-stages production/inventory systems with bottleneck ; Determination of transfer prices and inventory policy in supply chain of two enterprises
Bayem, Herman. "Apport des méthodes probabilistes aux études d’insertion des énergies renouvelables dans les systèmes électriques." Paris 11, 2009. https://tel.archives-ouvertes.fr/tel-00447151.
Renewable energy sources (RES) (especially wind and photovoltaic energy) have the particular feature of being variable and the controllabity of their production is very limited. For these reason, deterministic methods applied to RES' impact studies are inappropriate. The goal of this research work is to investigate the contribution of probabilistic methods for integration studies of RES in power systems. The management of parameters variations impacts on power systems brings up news challenges to system operators. The first step is the probabilistic modeling of the power system which is the first part of our work. The second step is the development of probabilistic methods which mix a probabilistic characterization of the power systems with a probabilistic model of RES production to estimate defined reliability criteria as well as probabilistic security criteria like risk of congestion, voltage level violations, etc. A probabilistic study is thus a risk analysis study, unlike a deterministic study which consists in the failure analysis of few specific situations. Pratical applications are presented and contributions of the probabilistic methods are discussed
Patchong, Alain. "Méthodes de modélisation, d'analyse et de diagnostic pour l'amélioration de l'efficacité d'un atelier de production." Valenciennes, 1997. https://ged.uphf.fr/nuxeo/site/esupversions/3681e5f7-c8a1-4c87-b5d3-67936f252624.
Dumetz, Ludwig. "Simulation combinée des processus de production et des processus de pilotage : analyse comparative de stratégies de pilotage pour la production de bois d'oeuvre." Doctoral thesis, Université Laval, 2018. http://hdl.handle.net/20.500.11794/30508.
In this thesis, we designed a simulation platform to compare and evaluate production planning and order management strategies for lumber production in North American sawmills. In our context, a strategy is composed of several parameters such as the choice of order acceptance policies, allowing to accept or refuse an order based on implemented rules, the choice of planning models and algorithms used at each stage of timber production, the choice of model at the tactical level, the coordination mechanisms used, to better coordinate the operations of several distinct entities or of several planning levels; this includes the exchange of information between tactical and operational planning levels or between entities / models used at the operational level to plan timber production. Today, it is extremely difficult for a company to know which management strategy to put in place. The general objective is then to evaluate and compare tactical and operational planning strategies for timber production, taking into account the company's market context and its production parameters. To achieve this goal, we divided it into four specific objectives that resulted in three publications. In the first specific objective, we developed a simulation model to represent the generation, acceptance and sale of an order for a sawmill. We coupled a production planning module to this simulation model that is responsible for inventory management and the generation of production plans. In a second objective, we use this simulation model to be able to evaluate the impact of order acceptance policies such as Available-to-promise (ATP), Capable-to-promise (CTP) and Stock policies on the company’s performance in terms of volume of accepted orders in a product flow environment diverge with co-production. Although these order acceptance policies have been widely studied in a traditional manufacturing context, the choice of one policy over another is far from being trivial in such a context of divergence flow. We show that in this type of context, the choice of an order acceptance policy rather than another depends strongly on the market and impacts the performance of the company, in terms of accepted orders and average annual inventory. This specific objective leads to the first publication. In a third specific objective, we evaluated coordination mechanisms used at the operational level between the different activities of the timber processing process, which is a decentralized process. The previous simulation platform has been adapted and previously published coordination mechanisms such as "Two-phase planning" or "bottleneck-first planning" are evaluated using a rolling horizon in an environment where orders are generated dynamically. We show that coordination mechanisms already published and tested in a static environment perform poorly in a dynamic environment. We therefore propose another "hybrid push / pull" coordination mechanism exploiting the decoupling point concept. This mechanism is better than the previous ones by allowing a greater number of sales, as well as a reduction in average inventory. This specific objective leads to a second publication. Finally, in a fourth specific objective, we are interested in production planning at the tactical and operational levels. We use the simulation model to compare and evaluate different information transmitted from the tactical level to the operational level by simulating the production system, the planning process and the market behavior. The tactical planning level is then taken into account to establish longer-term production planning. We show that the choice of the type of information to be transmitted from the tactical level to the operational level varies according to several factors, such as: the order acceptance policy (ATP, CTP) used by the company, the extent of seasonality selling prices, or whether or not being in an overcapacity market. This specific objective leads to third publication
Sedqui, Abdelfettah. "Nouvelle approche pour la classification des gammes de production." Lyon, INSA, 1995. http://www.theses.fr/1995ISAL0070.
[Resorting to Group Technology (GT) which is based on the exploitation of product similarities is always topical. Using this technique, we treat two essential problems that belong to the sequence classification. The first meeted is the analyse of assembly logic sequences of product. It is a question to select an alternative sequences verifying criteria in order to reach economic or technique objectives fixed by the firm. The second problem is the classification into families of manufacturing sequences that have similar manufacturing process for FMS (Flexible Manufacturing System) design. So, we propose an original method to solve the first problem. This method, based on hypergraphs generated by tree structure , permit : - the representation of binary sequences by describing the product assembling steps, highlight the parallel character and / or sequential logic of the assembly process , - the analyse of all sequences by calculation of distance between all admissible sequences. This method is used in dynamic control of assembling sequences. To solve the second problem, we propose a new approach based on language theory for sequences classification with keeping the prior approaches based on hierarchic classification : - we treat fundamental case of linear sequences. We propose distance between sequences that verify criteria described in the prior works. - after, we treat the case of arborescent sequences. We propose an algorithm for distance calculation between trees generally and binary trees in particular. This work permit to generalize the works that treat only linear sequences and permit to exploit the task parallelism in assembly sequence. - we solve too the data representation problem when an operation is repeating himself any times into a sequence. ]
Dagenais, Pierre. "Étude et développement de méthodes pour la production et la détection d'anticorps anti-peptides." Thèse, Université de Sherbrooke, 1994. http://hdl.handle.net/11143/12083.
Shahzad, Muhammad Kashif. "Exploitation dynamique des données de production pour améliorer les méthodes DFM dans l'industrie Microélectronique." Phd thesis, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-00771672.
Durcos, Sylviane. "Outils informatiques supports aux méthodes de modélisation et de conception de systèmes de production." Bordeaux 1, 1995. http://www.theses.fr/1995BOR10676.
Ha, Thi Binh Minh. "Contributions à l'étude des méthodes de production de masse des cellules endothéliales cornéennes humaines." Thesis, Saint-Etienne, 2014. http://www.theses.fr/2014STET001T/document.
Corneal endothelial engineering is becoming a more and more realistic solution to restore vision from corneal edema. This method focus to regenerate corneal endothelium by direct injection of corneal endothelial cells (ECs) into patient anterior chamber at the early stage of endothelial dystrophies, or by grafting a transparent biocompatible material covered by a monolayer of ECs. These two techniques require both in vitro isolation and amplification of ECs or endothelial-like cells. In this thesis, different strategies to obtain a high quantity of functional ECs for clinical application are explored: 1- Due to the limit proliferative capacity of EC, the first strategy consists to analyze mechanisms implicated EC cell cycle arrest and then to optimize protocol for native EC isolation or for cell proliferation activation ex vivo. This is summarized in three publications. The first publication describes the cell cycle regulation by comparing transcriptional expression of 112 genes in 6 biological models of EC with different proliferative profile: in vivo, postmortem, organ-culture, confluent primary culture, non confluent primary culture and immortalized cell line. , The key molecular actors identified using the combining microarray analysis and gene ontology methods are consistent with previous findings about oxidative DNA damage mechanism. The second publication characterizes EC differentiation process and its impact on EC proliferative capacity in old donor corneas. Analyses of differentiation/progenitor markers and of proliferative capacity underline the differentiation process of EC from the centre to the peripheral corneal endothelium. Thereby, an optimized culture protocol was developed, allowing the formation of high-density monolayer (> 2000 cells/mm2) with stable endothelial morphology. We proved the possibility to make profit from a majority of old-donor cornea grafts invalidated for penetrating graft In the third publication, the activation of endothelial cell cycle by electric pulses directly in corneal graft was characterized. We confirm the activation of endothelial cell cycle at different phases but also the damage of tissue during electroporation. 2- Second strategy consists of the amplification of ECs from potential EC progenitors. Using sphere forming culture and a new method to detect slow-cycling cells, we demonstrate the existence of "young" ECs population with higher proliferative capacity in corneal periphery. The isolation of ECs by sphere formation is one possible step for ECs selection in vitro. 3- The differentiation of embryonic stem cells, mesenchymal stem cells or induced pluripotent stem cells into corneal endothelial cells is the third approach considered by our laboratory. The manipulation of stem cells differentiation would be based on the molecular mechanisms implicated in the formation of corneal endothelium from periocular mesenchymal cells described in the first part of the bibliography. Finally, in order to validate the quality of endothelial cell mass obtained, we revisited recent methods for the evaluation of corneal endothelial identity (immunolocalisation of specific markers), for the measurement of pump activity of cell monolayer (Ussing chamber, perfusion chamber) or directly in deswelled cornea using the bioreactor patented by the BiiGC laboratory
Oré, Albornoz Ernesto. "Sur les méthodes de décomposition proximale appliquées à la planification de production électrique en environnement incertain." Thesis, Université Clermont Auvergne (2017-2020), 2018. http://www.theses.fr/2018CLFAC083/document.
Rigot-Muller, Patrick. "Les évolutions de la fonction méthodes dans l'industrie automobile : outils et enjeux organisationnels." Paris, ENMP, 2004. http://www.theses.fr/2004ENMP1257.
Lenoir, Arnaud. "Modèles et algorithmes pour la planification de production à moyen terme en environnement incertain : application de méthodes de décomposition proximales : Arnaud Lenoir." Clermont-Ferrand 2, 2008. http://www.theses.fr/2008CLF21875.
Nyouki, Evariste. "Asymétries et externalités d'informations, stratégies des compagnies et efficacité informationnelle de l'exploration pétrolière." Montpellier 1, 1998. http://www.theses.fr/1998MON10060.
Emiel, Gregory. "Méthodes d'optimisation non differentiable pour la résolution de grands problèmes. Applications à la gestion à moyen-terme de la production." Phd thesis, Université Panthéon-Sorbonne - Paris I, 2008. http://tel.archives-ouvertes.fr/tel-00363868.
Chappaz, Eric. "Simulateur fondé sur la connaissance pour le pilotage de systèmes de production." Aix-Marseille 3, 1989. http://www.theses.fr/1989AIX30054.
Lee, Kwang Hyung. "Analyse et modélisation des systèmes de production par les réseaux de Petri." Lyon, INSA, 1985. http://www.theses.fr/1985ISAL0003.
In the f ace of the increased complexity of production systems, computer may allow managers an easy problem solving in production control. This trend of computerization has brought about a necessity of perfect understanding of such systems. The need of a tool or method for analysis of complex systems has been emphasized. In this thesis, Petri nets are chosen as a method of analysis and conceptualisation of automated production systems, and as a common language among computer scientists and production managers. The aptitude of Petri nets for modelling and analysis of production systems is studied and compared with other principal graphic models. The comparative study shows that the Petri nets has the best modelling and analysing power for the production systems. It is also pointed out that the space of reachable states of a Petri net is large in general and often it gives difficulties in analysing a complex net. A new method of hierarchical reduction on petri net is proposed et analyse a complex net. The prosed method conserves the properties of petri net such as liveness, boundedness and proper termination. This method allows to decompose hierarchically a net ant to analyse it by its reduced net and its sub-nets. This procedure od reduction has been automated. As an application, a flexible manufacturing system was modelled by petri and this net has been reduced by this automated process in facilitating its analysis
Agoua, Xwégnon. "Développement de méthodes spatio-temporelles pour la prévision à court terme de la production photovoltaïque." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEM066/document.
The evolution of the global energy context and the challenges of climate change have led to anincrease in the production capacity of renewable energy. Renewable energies are characterized byhigh variability due to their dependence on meteorological conditions. Controlling this variabilityis an important challenge for the operators of the electricity systems, but also for achieving the Europeanobjectives of reducing greenhouse gas emissions, improving energy efficiency and increasing the share of renewable energies in EU energy consumption. In the case of photovoltaics (PV), the control of the variability of the production requires to predict with minimum errors the future production of the power stations. These forecasts contribute to increasing the level of PV penetration and optimal integration in the power grid, improving PV plant management and participating in electricity markets. The objective of this thesis is to contribute to the improvement of the short-term predictability (less than 6 hours) of PV production. First, we analyze the spatio-temporal variability of PV production and propose a method to reduce the nonstationarity of the production series. We then propose a deterministic prediction model that exploits the spatio-temporal correlations between the power plants of a spatial grid. The power stationsare used as a network of sensors to anticipate sources of variability. We also propose an automaticmethod for selecting variables to solve the dimensionality and sparsity problems of the space-time model. A probabilistic spatio-temporal model has also been developed to produce efficient forecasts not only of the average level of future production but of its entire distribution. Finally, we propose a model that exploits observations of satellite images to improve short-term forecasting of PV production
Roboam, Michel. "Modèles de références et intégration des méthodes d'analyse pour la conception des systémes de production." Bordeaux 1, 1988. http://www.theses.fr/1988BOR10551.
Lhéritier, Bernard. "Méthodes analytiques pour l'évaluation de réseaux de files d'attentes : applications aux systèmes flexibles de production." Clermont-Ferrand 2, 1990. http://www.theses.fr/1990CLF21304.
Blouin, Véronique. "Développement de méthodes de production et d'analyse de vecteurs recombinants dérivés de l'adéno-associated virus." Nantes, 2007. https://archive.bu.univ-nantes.fr/pollux/show/show?id=460f68ce-89fe-4d3a-a3bf-7702282acf51.
Numerous in vivo studies have demonstrated that rAAV vectors can efficiently transduce many tissues and lead to stable gene expression. These encouraging results have led to a rapid development of clinical trials involving the use of rAAV-2 vectors. However, the obtainment of large-scale rAAV-2 vector stocks for clinical assay is still hampered by the conventional production methods that are not efficient and difficult to scale-up. We develop a simple and reproducible alternative method based on stable packaging hybrid cell lines containing integrated into their genome the rep-cap genes of serotypes -1 and -5. Another critical step for the assessment of these vectors in clinical trials is the method used for purification of rAAV particles. We developed a purification method, which comprises two-step chromatography process based on the use of ion- exchange resins. This process can be easily scaled up and could be applied to different AAV serotypes. We purified the serotype-5, the most divergent in terms of capsid composition compared to AAV-2. The rAAV stocks obtained are pure and transduced efficiently target tissues. To characterize rAAV capsid from different serotype, we have shown that proteolytic digestion of rAAV virions is able to generate a characteristic cleavage pattern that can be use to distinguish AAV-2 from AAV-1 and -5
Li, Xiaohui. "Ordonnancement de la production : systèmes hybrides." Troyes, 2011. http://www.theses.fr/2011TROY0015.
The work presented in this thesis is a part of the MOSYP, state-region project. The goal of this project is to develop tools and techniques to improve the competitiveness of production systems. The objective is to analyze the variables of the studied systems and to propose efficient functioning models. In this work, parallel machines scheduling problem and a hybrid flowshop scheduling problem (HFS) have been studied. The sequence dependent setup times, the released date and the due date are considered. A multiobjective resolution has been adopted and two criteria are considered: the makespan (maximum duration of treatment) and the total tardiness. Mathematical formulations, an exact resolution and approximated methods are proposed. The latter are based on evolutionary algorithms: NSGA-II and SPEA-II. A fuzzy logic controller is used to improve the parameters settings of these algorithms. Then, an algorithm based on the Lorenz dominance is adapted to improve the efficiency of the Pareto front. A new decomposition method is also proposed to decompose the HFS problem into sub-problems. To prove the efficiency of these algorithms, an exact method (TPM) is developed to identify the optimal solutions. Finally, a simulation based optimization method is tested. A practical case study proposed by the project partners has been conducted. A simulation model under the ARENA software is proposed to evaluate the performances as well as an optimization technique
Hadj, said Ahmed. "Intégration du stockage dans les méthodes de planification des réseaux électriques basse tension." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAT004/document.
The opening up of energy markets and new uses have led to significant changes in distribution grids, in particular low-voltage grids. Notably, it has led to an augmentation in the integration of renewable energy production, an increase in the peak consumption, among others. This is accompanied by the appearance of the electrical constraints with which power systems must cope. This has resulted in the development multiple flexibility capabilities such as load/source management or energy storage, providing new solutions, now to be considered in planning methods. This thesis studies the issue of energy storage in the low-voltage grid planning. The first part of this thesis studies the impact of storage and photovoltaic production on variables involved in distribution grid planning. In the second part, a method for calculating the cost of losses is adapted to the presence of energy storage and/or PV production. Finally, advanced d operation algorithms are developed to illustrate the economic value of energy storage in LV distribution grid planning, compared to a more expensive conventional planning method
Lafontaine, Édith. "Méthodes et mesures pour l'évaluation de la performance et de l'efficacité des équipements miniers de production." Thesis, Université Laval, 2006. http://www.theses.ulaval.ca/2006/23714/23714.pdf.
Lafontaine, Edith. "Méthodes et mesures pour l'évaluation de la performance et de l'efficacité des équipements miniers de production." Master's thesis, Université Laval, 2006. http://hdl.handle.net/20.500.11794/18357.
Vallières, Marise. "Comparaison de méthodes de refroidissement et de déshumidification pour une production en serre de tomates biologiques." Master's thesis, Université Laval, 2018. http://hdl.handle.net/20.500.11794/29481.
Balin, Savaş. "Amélioration de processus de production de services par la simulation." Paris 9, 2007. https://portail.bu.dauphine.fr/fileviewer/index.php?doc=2007PA090020.
The purpose of this thesis is to study the improvement of services production. We begin the first part by discussing service concepts. We examine two points of view: “conceived quality” and “perceived quality”. Process improvement consists in a process transformation which aims at increasing system “effectiveness” and “efficiency”. We defend that the use of simulation is essential for the instrumentation of services process conception and transformation. In the second part, we discuss simulation techniques: “Object Based Simulation (OBS)”, “Object Oriented Simulation (OOS)” and “Multi-Agent Based Simulation (MABS)”. We claim that OBS can be sufficient to realize objectives mentioned above and to model some of the most important perceived quality dimensions, which is not the common use of this technique. We finish our thesis by discussing the contribution of the simulation on an extremely complex example, a hospital emergency department
Idri, Imane. "Mise en place, extrapolation et optimisation d’un procédé de production de caramels prébiotiques riches en DiAnhydrides de Fructose (DAF) : exploration d’autres méthodes de production." Paris 6, 2010. http://www.theses.fr/2010PA066447.
Weil, Georges. "L'hôpital au service du malade : transfert des concepts, des méthodes, des outils de la gestion de la production." Grenoble 1, 1990. https://theses.hal.science/tel-00337856.
Berchet, Claire. "Modélisation pour la simulation d'un système d'aide au pilotage industriel." Grenoble INPG, 2000. http://www.theses.fr/2000INPG0133.
Jia, Tianqiang. "Vers une meilleure gestion des ressources d'un groupe autonome de fabrication." Tours, 1998. http://www.theses.fr/1998TOUR4023.
Vong, Lilita. "SPECIATION CHIMIQUE DU FER DANS L'OCEAN : Les complexes fer-porphyrines, méthodes de détection et mécanismes de production." Phd thesis, Université de la Méditerranée - Aix-Marseille II, 2008. http://tel.archives-ouvertes.fr/tel-00354951.
Les porphyrines, molécules ubiquistes synthétisées par tous les organismes, sont capables de chélater le fer, sous la forme de complexes fer-porphyrines. A la mort des organismes, ces complexes pourraient donc être libérés dans l'eau de mer en tant que produits de dégradation cellulaire et pourraient participer à la complexation organique du fer. L'objectif de ce travail de thèse est donc de tester cette hypothèse.
La première partie consistait à mettre au point une première méthode de dosage correspondant à une analyse par injection en flux et détection par chimiluminescence (FIA-CL). Un protocole a été développé pour l'analyse d'échantillons d'eau de mer. Des tests d'interférences suggèrent que la FIA-CL est bien spécifique aux complexes fer-porphyrines. Plusieurs tests d'augmentation de la sensibilité ont permis d'atteindre une limite de détection de 0,11 nM d'équivalent hémine (fer-porphyrine de référence). Des premières concentrations en fer-porphyrines ont ainsi pu être déterminées dans différents types d'environnements naturels (eau de mer, eau douce et eau intermédiaire) riches en matière organique.
La seconde partie visait à étudier un processus de relarguage des fer-porphyrines, tel que le broutage du phytoplancton par le zooplancton. Lors de cette étude, l'existence d'une interférence provoquée par les radicaux superoxyde générés lors de la croissance du phytoplancton a été mise en évidence, lors de la mesure des fer-porphyrines. Un protocole d'élimination de ces interférences a donc été établi. Par des expériences de culture, avec un modèle simple « phytoplancton-zooplancton », la libération des fer-porphyrines dans l'eau de mer a pu être mise en évidence.
Ce travail de thèse pourra permettre d'étudier le devenir des fer-porphyrines dans l'eau de mer et leur rôle dans la complexation organique du fer.