Статті в журналах: "Metabolic interventions"

1

Alexander, L., and J. P. Despres. "Metabolic Syndrome Interventions." MD Conference Express 7, no. 5 (October 1, 2007): 24–25. http://dx.doi.org/10.1177/155989770700700517.

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Aude, Y. Wady, Pedro Mego, and Jawahar L. Mehta. "Metabolic syndrome: dietary interventions." Current Opinion in Cardiology 19, no. 5 (September 2004): 473–79. http://dx.doi.org/10.1097/01.hco.0000134610.68815.05.

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Vargas, Eric J., and Barham K. Abu Dayyeh. "Endoluminal bariatric and metabolic interventions." Techniques in Gastrointestinal Endoscopy 17, no. 4 (October 2015): 171–77. http://dx.doi.org/10.1016/j.tgie.2016.01.006.

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4

Weindruch, R., K. P. Keenan, J. M. Carney, G. Fernandes, R. J. Feuers, R. A. Floyd, J. B. Halter, et al. "Caloric Restriction Mimetics: Metabolic Interventions." Journals of Gerontology Series A: Biological Sciences and Medical Sciences 56, Supplement 1 (March 1, 2001): 20–33. http://dx.doi.org/10.1093/gerona/56.suppl_1.20.

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5

Rosenfeldt, Franklin. "Metabolic interventions in myocardial preservation." AustralAsian Journal of Cardiac and Thoracic Surgery 2, no. 2 (August 1993): 80–82. http://dx.doi.org/10.1016/1037-2091(93)90052-6.

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Cortez, Ramiro Marx Alves, Ana Míria de Oliveira Batista, Mariana Rodrigues da Rocha, Isa Moema de Sales Santos, Jayne Ramos Araújo Moura, and Ana Roberta Vilarouca da Silva. "Students’ knowledge of metabolic syndrome after educational intervention." Revista Brasileira de Enfermagem 71, suppl 4 (2018): 1493–99. http://dx.doi.org/10.1590/0034-7167-2017-0342.

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ABSTRACT Objective: To analyze the knowledge of children and adolescents about risk factors for metabolic syndrome (MS) before and after educational interventions. Method: A quasi-experimental, comparative, prospective and intervention study conducted in 2015 and 2016 with 43 students in the city of Picos (state of Piauí-PI). Five health education meetings were held. For the knowledge analysis, was applied a questionnaire at three different moments. Results: Participants’ mean age was 12.6 years (± 2.1), of which 60.5% were female. The ‘More than good’ level of knowledge went from 20.9% to 55.8% after interventions. When evaluated late, students maintained a higher level of knowledge compared to before the interventions. Most said they were able to change their lifestyle after educational meetings. Conclusion: The educational intervention promoted increase of knowledge and stimulated changes in attitudes related to risk factors associated with MS.

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Wang, Guorong. "Analysis of Ketogenic Metabolic Interventions for Obesity." SHS Web of Conferences 144 (2022): 01010. http://dx.doi.org/10.1051/shsconf/202214401010.

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According to statistics and surveys by the World Health Organization, the obesity ratio of people in the world nearly tripled since 1975; in 2016, more than 1.9 billion adults aged 18 and older were overweight. Obesity and overweight are defined as abnormal or excessive fat accumulation that presents a risk to health. Obesity prevention and intervention is a serious health problem facing humanity. This article is an analysis of interventions for obesity from the perspective of ketogenic metabolism, by supplementing exogenous ketones or increasing endogenous ketone levels. By analyzing experimental data on the metabolic mechanisms of ketones, exogenous ketones esters on body weight, food intake and satiety hormones, this paper concludes that exogenous ketones have a positive effect on interventions in obesity. A study of the literature revealed that the involvement of ketogenesis in the process of fat metabolism is still a very vague concept.

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8

Kim, Gaeun, Ji-Soo Lee, and Soo-Kyoung Lee. "A Technology-Mediated Interventional Approach to the Prevention of Metabolic Syndrome: A Systematic Review and Meta-Analysis." International Journal of Environmental Research and Public Health 18, no. 2 (January 10, 2021): 512. http://dx.doi.org/10.3390/ijerph18020512.

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Background: Technology-mediated interventions help overcome barriers to program delivery and spread metabolic syndrome prevention programs on a large scale. A meta-analysis was performed to evaluate the impact of these technology-mediated interventions on metabolic syndrome prevention. Methods: In this meta-analysis, from 30 January 2018, three databases were searched to evaluate interventions using techniques to propagate diet and exercise lifestyle programs for adult patients with metabolic syndrome or metabolic risk. Results: Search results found 535 citations. Of these, 18 studies met the inclusion criteria analyzed in this article. The median duration of intervention was 4 months and the follow-up period ranged from 1.5 to 30 months. The standardized mean difference (SMD) between the two groups was waist circumference −0.35 (95% CI −0.54, −0.15), triglyceride −0.14 (95% CI −0.26, −0.03), fasting blood glucose −0.31 (95% CI −0.42, −0.19), body weight −1.34 (95% CI −2.04, −0.64), and body mass index −1.36 (95% CI −2.21, −0.51). There was no publication bias in this study. Conclusion: Technology-mediated intervention improved clinically important metabolic syndrome related indicators such as excess body fat around the waist, fasting glucose, and body mass index. These interventions will play an important role in the dissemination of metabolic syndrome prevention programs.

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Kim, Gaeun, Ji-Soo Lee, and Soo-Kyoung Lee. "A Technology-Mediated Interventional Approach to the Prevention of Metabolic Syndrome: A Systematic Review and Meta-Analysis." International Journal of Environmental Research and Public Health 18, no. 2 (January 10, 2021): 512. http://dx.doi.org/10.3390/ijerph18020512.

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Background: Technology-mediated interventions help overcome barriers to program delivery and spread metabolic syndrome prevention programs on a large scale. A meta-analysis was performed to evaluate the impact of these technology-mediated interventions on metabolic syndrome prevention. Methods: In this meta-analysis, from 30 January 2018, three databases were searched to evaluate interventions using techniques to propagate diet and exercise lifestyle programs for adult patients with metabolic syndrome or metabolic risk. Results: Search results found 535 citations. Of these, 18 studies met the inclusion criteria analyzed in this article. The median duration of intervention was 4 months and the follow-up period ranged from 1.5 to 30 months. The standardized mean difference (SMD) between the two groups was waist circumference −0.35 (95% CI −0.54, −0.15), triglyceride −0.14 (95% CI −0.26, −0.03), fasting blood glucose −0.31 (95% CI −0.42, −0.19), body weight −1.34 (95% CI −2.04, −0.64), and body mass index −1.36 (95% CI −2.21, −0.51). There was no publication bias in this study. Conclusion: Technology-mediated intervention improved clinically important metabolic syndrome related indicators such as excess body fat around the waist, fasting glucose, and body mass index. These interventions will play an important role in the dissemination of metabolic syndrome prevention programs.

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10

Lahsen, Rodolfo, and Marcos Berry. "Surgical interventions to correct metabolic disorders." British Journal of Diabetes & Vascular Disease 10, no. 3 (May 2010): 143–47. http://dx.doi.org/10.1177/1474651410370302.

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11

Mierau, Susanna B., and Ann M. Neumeyer. "Metabolic interventions in Autism Spectrum Disorder." Neurobiology of Disease 132 (December 2019): 104544. http://dx.doi.org/10.1016/j.nbd.2019.104544.

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12

Bihlmeyer, Nathan A., Lydia Coulter Kwee, Clary B. Clish, Amy Anderson Deik, Robert E. Gerszten, Neha J. Pagidipati, Blandine Laferrère, et al. "Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions." PLOS ONE 16, no. 5 (May 27, 2021): e0240764. http://dx.doi.org/10.1371/journal.pone.0240764.

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Obesity is an epidemic internationally. While weight loss interventions are efficacious, they are compounded by heterogeneity with regards to clinically relevant metabolic responses. Thus, we sought to identify metabolic biomarkers that are associated with beneficial metabolic changes to weight loss and which distinguish individuals with obesity who would most benefit from a given type of intervention. Liquid chromatography mass spectrometry-based profiling was used to measure 765 metabolites in baseline plasma from three different weight loss studies: WLM (behavioral intervention, N = 443), STRRIDE-PD (exercise intervention, N = 163), and CBD (surgical cohort, N = 125). The primary outcome was percent change in insulin resistance (as measured by the Homeostatic Model Assessment of Insulin Resistance [%ΔHOMA-IR]) over the intervention. Overall, 92 individual metabolites were associated with %ΔHOMA-IR after adjustment for multiple comparisons. Concordantly, the most significant metabolites were triacylglycerols (TAGs; p = 2.3e-5) and diacylglycerols (DAGs; p = 1.6e-4), with higher baseline TAG and DAG levels associated with a greater improvement in insulin resistance with weight loss. In tests of heterogeneity, 50 metabolites changed differently between weight loss interventions; we found amino acids, peptides, and their analogues to be most significant (4.7e-3) in this category. Our results highlight novel metabolic pathways associated with heterogeneity in response to weight loss interventions, and related biomarkers which could be used in future studies of personalized approaches to weight loss interventions.

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13

GREY, MARGARET. "Interventions for Children with Diabetes and Their Families." Annual Review of Nursing Research 18, no. 1 (January 2000): 149–70. http://dx.doi.org/10.1891/0739-6686.18.1.149.

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The purpose of this review is to examine the research literature on interventions for children with type 1 diabetes and their families, with a specific focus on three types of intervention (educational and psychosocial/behavioral interventions that focus on individuals with diabetes and family interventions for families, usually parents, of individuals with diabetes). The aim of the review is to determine what interventions produce what outcomes in what populations of children and families. The review includes articles that met the following criteria: (a) empirical study reporting the impact of an intervention on such outcomes as knowledge, behavior, self-care, and metabolic control; (b) children with type 1 diabetes and/or their families as primary subjects; (c) publication between 1980 and January 1, 1999; and (d) publication in English. A total of 41 published papers were included. On the basis of this review, conclusions are as follows: (a) Educational interventions are useful in improving diabetes knowledge but not consistently helpful in improving metabolic control; (b) psychosocial interventions, especially coping skills training and peer support, assist primarily adolescents to improve adjustment and sometimes metabolic control; and (c) family interventions may be helpful in reducing parent-child conflict about diabetes management and care.

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14

Kim, Yoona, Jennifer Keogh, and Peter Clifton. "Nuts and Cardio-Metabolic Disease: A Review of Meta-Analyses." Nutrients 10, no. 12 (December 6, 2018): 1935. http://dx.doi.org/10.3390/nu10121935.

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Objectives: Accumulating epidemiological and intervention evidence suggest that nut consumption is associated with reduced incidence of some cardiometabolic diseases. However, to date no review of meta-analyses of epidemiological and intervention studies has evaluated the effects of nut consumption on cardiometabolic disease. Design/Results: Electronic searches for meta-analyses of epidemiological and intervention studies were undertaken in PubMed®/MEDLINE®. Meta-analyses of prospective studies show that nut consumption appears to be associated with reduced all-cause mortality by 19–20% (n = 6), cardiovascular disease (CVD) incidence (19%; n = 3) and mortality (25%; n = 3), coronary heart disease (CHD) incidence (20–34%; n = 2) and mortality (27–30%; n = 2) and stroke incidence (10–11%; n = 7) and mortality (18%; n = 2). No association between nut consumption and the risk of type 2 diabetes mellitus (T2DM) was observed in meta-analyses of prospective studies, whereas a decrease in fasting blood glucose ranging from 0.08 to 0.15 mmol/L was observed in 3 meta-analyses of intervention studies. In the interventions, nut consumption also had favorable effects on total cholesterol (0.021 to 0.28 mmol/L reduction from 8 meta-analyses of interventions) and low-density lipoprotein cholesterol (0.017 to 0.26 mmol/L reduction from 8 meta-analyses of interventions) and endothelial function (0.79 to 1.03% increase in flow-mediated dilation from 4 meta-analyses of interventions). Nut consumption did not significantly affect body weight. Nut consumption had no effect on inflammatory markers in intervention studies. The effect on blood pressure was inconsistent. A higher nut consumption was associated with a lower incidence of hypertension in prospective studies, while nut consumption did not improve blood pressure in intervention studies. Conclusions: Nut consumption appeared to be associated with lower all-cause mortality and CVD and CHD mortality. There was no association between nut consumption and the incidence of T2DM although fasting blood glucose is decreased in intervention studies. In intervention studies nuts lower total cholesterol and low-density lipoprotein cholesterol (LDL-C).

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Chang, Shu-Hung, Nai-Hui Chien, and Ching-Yi Yu. "Long-Term Lifestyle Intervention in Elderly With Metabolic Syndrome." Clinical Nursing Research 28, no. 6 (December 24, 2017): 658–75. http://dx.doi.org/10.1177/1054773817749923.

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The purpose of this study was to examine the effects of a long-term community-based lifestyle intervention on the biochemical indicators and prevalence of metabolic syndrome among elderly adults. This was a randomized controlled trial in northern Taiwan from August 2013 to February 2015. Sixty-nine elderly adults participated in this study. There were three measurements. The experimental group participated in exercise and diet interventions. The control group participated in the exercise intervention. Repeated measurement and ANCOVA were performed to evaluate the effectiveness. After 18 months, body weight (1.06 kg), body mass index (1.21 kg/m2), waist circumference (3.32 cm), blood pressure, and prevalence (30.4%) of metabolic syndrome were significantly reduced in all subjects. There were significant differences in waist circumference and high-density lipoprotein cholesterol between the two groups. This intervention can lower the indicators and prevalence of metabolic syndrome. Exercise and diet interventions could promote further metabolic changes.

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Zahtamal, Zahtamal, Wasilah Rochmah, Yayi Suryo Prabandari, and Lientjie K. Setyawati. "Effects of Multilevel Intervention in Workplace Health Promotion on Workers’ Metabolic Syndrome Components." Kesmas: National Public Health Journal 11, no. 4 (May 24, 2017): 198. http://dx.doi.org/10.21109/kesmas.v11i4.1279.

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Approximately 10–30% of adult Asian people had metabolic syndrome. This study aimed to reveal effects of workplace health promotion (WHP) with multilevel interventions on workers’ metabolic syndrome component. This study was conducted in 2014-2015 using quasi-experimental design with multilevel subject intervention in Indonesia. The WHP program for multilevel intervention group included 12 weeks of combined physical training, diet, health education, social support, and advocacy. The WHP program for control group included only health education. Instruments used included IPAQ, table of 24-hour food recall, physical measurement tools, and clinical laboratories. Data analysis used Marginal Homogeneity, paired sample t-test, Mc Nemar, and Wilcoxon test. WHP multilevel intervention could improve physical activity and the nutrition in accordance with diet of workers, in particular to increase the amount of fiber and a reduce cholesterol intake. The improved metabolic syndrome components due to the influence of multilevel WHP were systolic and diastolic blood pressure, and fasting blood glucose levels (p value < 0.05). Overall, workplace health promotion multilevel interventions are effective for the management of metabolic syndrome components.AbstrakSekitar 10-30% orang Asia dewasa mengalami sindrom metabolik. Penelitian ini bertujuan untuk mengungkap efek Promosi Kesehatan di Tempat Kerja PKDTK dengan intervensi multilevel pada komponen/penanda pekerja yang menderita sindrom metabolik. Penelitian ini dilakukan pada tahun 2014-2015 dengan menggunakan desain quasi experimental dengan intervensi subjek secara multilevel di Indonesia. Program PKDTK untuk kelompok intervensi multilevel berupa kombinasi latihan fisik, diet, pendidikan kesehatan, dukungan sosial, dan advokasi salama 12 minggu. Program PKDTK untuk kelompok kontrol hanya pendidikan kesehatan. Instrumen penelitian seperti IPAQ, table food recall 24 jam, alat pengukuran fisik, dan laboratorium klinis. Analisis data menggunakan Marginal Homogeneity, paired sample t, Mc Nemar, dan uji Wilcoxon. Intervensi PKDTK multilevel dapat meningkatkan aktivitas fisik dan asupan makanan yang sesuai dengan diet sindrom metabolik, khususnya untuk meningkatkan jumlah serat pangan dan pengurangan asupan kolesterol. Komponen sindrom metabolik yang membaik karena pengaruh PKDTK secara multilevel adalah tekanan darah sistolik dan diastolik, serta kadar glukosa darah puasa (nilai p < 0,05). Secara keseluruhan, intervensi PKDTK multilevel efektif untuk pengelolaan komponen sindroma metabolik pada pekerja.

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Michael, Sarah, and Kirsty MacDonald. "Improving rates of metabolic monitoring on an inpatient psychiatric ward." BMJ Open Quality 9, no. 3 (July 2020): e000748. http://dx.doi.org/10.1136/bmjoq-2019-000748.

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ObjectivesCardiovascular disease is the leading cause of premature death in patients with mental illness. Metabolic syndrome is a cluster of co-occurring cardiovascular risk factors, seen in high frequency in severe mental illness. Despite ease of diagnosis, monitoring is often poor across psychiatric populations. This report details a quality improvement initiative undertaken on an inpatient psychiatric ward to improve rates of metabolic monitoring.MethodsFour key interventions were developed: (1) A nurse-led intervention, where nurses were upskilled in performing metabolic monitoring, (2) Education was provided to all staff, (3) Introduction of a suite of interventions to improve metabolic risk and (4) Ongoing consumer involvement. A pre–post intervention study design was used to measure effectiveness, with an audit of metabolic monitoring rates performed 12 months after the intervention began.ResultsRates of weight and height monitoring both increased from 46.0% to 69.5% (p=0.0185) and body mass index (BMI) recordings increased from 33% to 63% (p=0.0031). Rates of waist circumference monitoring increased from 44.2% to 65.2% (p=0.0498). Blood pressure (BP) measurements increased from 88.5% to 100% (p=0.0188). Lipid monitoring rates improved from 23% to 69.5% (p=0.001). Rates of glucose monitoring increased from 74% to 82.5% (p=0.8256), although this was not statistically significant.ConclusionsWe found that metabolic monitoring improved following these simple interventions, with a statistically significant increase in measurement rates of weight, BP, height, lipids, BMI and waist circumference (p<0.05). Overall monitoring of glucose also improved, although not to significant levels. The intervention was acceptable to both patients and staff.

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Schneider, Philipp, and Steffen Klamt. "Characterizing and ranking computed metabolic engineering strategies." Bioinformatics 35, no. 17 (January 12, 2019): 3063–72. http://dx.doi.org/10.1093/bioinformatics/bty1065.

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AbstractMotivationThe computer-aided design of metabolic intervention strategies has become a key component of an integrated metabolic engineering approach and a broad range of methods and algorithms has been developed for this task. Many of these algorithms enforce coupling of growth with product synthesis and may return thousands of possible intervention strategies from which the most suitable strategy must then be selectedResultsThis work focuses on how to evaluate and rank, in a meaningful way, a given pool of computed metabolic engineering strategies for growth-coupled product synthesis. Apart from straightforward criteria, such as a preferably small number of necessary interventions, a reasonable growth rate and a high product yield, we present several new criteria useful to pick the most suitable intervention strategy. Among others, we investigate the robustness of the intervention strategies by searching for metabolites that may disrupt growth coupling when accumulated or secreted and by checking whether the interventions interrupt pathways at their origin (preferable) or at downstream steps. We also assess thermodynamic properties of the pathway(s) favored by the intervention strategy. Furthermore, strategies that have a significant overlap with alternative solutions are ranked higher because they provide flexibility in implementation. We also introduce the notion of equivalence classes for grouping intervention strategies with identical solution spaces. Our ranking procedure involves in total ten criteria and we demonstrate its applicability by assessing knockout-based intervention strategies computed in a genome-scale model of E.coli for the growth-coupled synthesis of l-methionine and of the heterologous product 1,4-butanediol.Availability and implementationThe MATLAB scripts that were used to characterize and rank the example intervention strategies are available at http://www2.mpi-magdeburg.mpg.de/projects/cna/etcdownloads.html.Supplementary informationSupplementary data are available at Bioinformatics online.

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Delshad Noghabi, Ali, Mohammad Hossein Bayazi, and Ali Reza Rajaei. "Effectiveness of Self-management Interventions Based on Cognitive-behavioral Group Therapy on Life-style Among Adults With Metabolic Syndrome: A Randomized Clinical Trial." Journal of Research and Health 11, no. 2 (April 1, 2021): 113–22. http://dx.doi.org/10.32598/jrh.11.2.321.3.

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Background: Metabolic syndrome is an asymptomatic disorder and an important risk factor for cardiovascular disease and type 2 diabetes. Lifestyle modification and self-management of health-promoting behaviors are the most important actions to control metabolic syndrome. This study was done to investigate the effectiveness of self-management interventions based on group Cognitive-Behavioral Therapy (CBT) on lifestyle among adults with metabolic syndrome. Methods: This research was a randomized clinical trial study. First, 80 adults with metabolic syndrome were selected using the convenience sampling method, and then, using the randomized blockchain method, they were divided into two groups of 40 people (intervention and control groups). Data collection using the Health Promotion Lifestyle Profile II Questionnaire (HPLP II) was performed in two stages before and three months after the intervention. Teaching self-management interventions based on cognitive-behavioral therapy was done twice a week for eight 90-minute sessions. Data were analyzed using the Chi-square test, independent t-tests, and Analysis of Covariance (ANCOVA). A P-value less than 0.05 was considered significant. Results: the results of ANCOVA showed that self-management intervention based on group CBT had a significant effect on the dimensions of lifestyle, including exercise and physical activity with an effect size of 0.51, nutrition with 0.49, health responsibility with 0.39, and stress management with 0.32 (P<0.05), but it did not significantly affect the two dimensions of self-actualization and spiritual growth (effect size= 0.003, P=0.669) and interpersonal relationships (effect size= 0.029, P=0.151). Conclusion: Self-management interventions based on group CBT can improve lifestyle and some dimensions in adults with metabolic syndrome. Identifying people with metabolic syndrome and performing effective interventions with the active participation of the individual through self-management based on cognitive-behavioral therapy seem necessary.

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Booij, Harmen G., Anne M. Koning, Harry van Goor, Rudolf A. de Boer, and B. Daan Westenbrink. "Selecting heart failure patients for metabolic interventions." Expert Review of Molecular Diagnostics 17, no. 2 (December 28, 2016): 141–52. http://dx.doi.org/10.1080/14737159.2017.1266939.

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Smolock, Christopher J., Javier Anaya Ayala, Jean Bismuth, Joseph J. Naoum, Hosam F. El-Sayed, Heitham Hassoun, Eric K. Peden, Alan B. Lumsden, and Mark G. Davies. "Impact of Metabolic Syndrome on SFA Interventions." Journal of Vascular Surgery 52, no. 6 (December 2010): 1734. http://dx.doi.org/10.1016/j.jvs.2010.10.009.

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Rall, L. C. "Rheumatoid cachexia: metabolic abnormalities, mechanisms and interventions." Rheumatology 43, no. 10 (July 13, 2004): 1219–23. http://dx.doi.org/10.1093/rheumatology/keh321.

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Tawadros, Augustine, Michael Makar, Michel Kahaleh, and Avik Sarkar. "Overview of bariatric and metabolic endoscopy interventions." Therapeutic Advances in Gastrointestinal Endoscopy 13 (January 2020): 263177452093523. http://dx.doi.org/10.1177/2631774520935239.

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The rise of endoscopic techniques allowing weight loss offers an attractive alternative to surgical interventions in Western countries where the obesity epidemic has risen dramatically. Endoscopists are well positioned to manage obesity given their broad-based medical knowledge, understanding of gastrointestinal physiology, and training in endoscopic technique. The field of bariatric and metabolic endoscopy has permitted the development of several efficacious and safe technologies. This review focuses on techniques and devices used for endoscopic management of obesity, as well as the fundamental justifications to offer those therapies to obese patients.

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Vu, Lan, Noah J. Switzer, Christopher De Gara, and Shahzeer Karmali. "Surgical interventions for obesity and metabolic disease." Best Practice & Research Clinical Endocrinology & Metabolism 27, no. 2 (April 2013): 239–46. http://dx.doi.org/10.1016/j.beem.2012.12.001.

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Rice, Jessie, and Ujjwal Ramtekkar. "Integrative Management of Metabolic Syndrome in Youth Prescribed Second-Generation Antipsychotics." Medical Sciences 8, no. 3 (August 17, 2020): 34. http://dx.doi.org/10.3390/medsci8030034.

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Weight gain and metabolic syndrome are common side effects of second-generation antipsychotics and carry significant health consequences both in childhood and into adulthood. This review highlights evidence-based, non-pharmacologic interventions to assist in the management of these side effects. Such intervention categories include dietary, physical activity, sleep, stress management, and nutritional supplementation. Interventions with the highest quality evidence include increasing the consumption of fruits, vegetables, and whole grains, increasing physical activity, improving sleep, and fish oil supplementation. We suggest that clinicians work with patients on managing metabolic side effects in a patient-centered way, incorporating principles of motivational interviewing, to reduce the risk of metabolic syndrome.

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Xing, Xiaolong, Fangchao Liu, Xueli Yang, Chen Huang, Dingding Zhang, Shufeng Chen, Jichun Chen, et al. "Central Blood Pressure Responses to Dietary Sodium and Potassium Interventions." American Journal of Hypertension 31, no. 5 (January 27, 2018): 582–89. http://dx.doi.org/10.1093/ajh/hpx209.

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Abstract BACKGROUND To explore how central hemodynamics respond to dietary sodium and potassium interventions, and whether the responses are associated with metabolic traits. METHODS We conducted a dietary intervention study including a 7-day low-sodium (51.3 mmol sodium/day) intervention, a 7-day high-sodium (307.8 mmol sodium/day) intervention, and a 7-day high-sodium with potassium supplementation (60.0 mmol potassium/day) intervention among 99 northern Chinese subjects aged 18–60 years. Five metabolic traits included abdominal obesity, high triglycerides, low HDL cholesterol, raised blood pressure (BP), and high glucose. Central hemodynamics were measured at baseline and during each intervention. RESULTS Central systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP), and augmentation index (AIx@75) significantly decreased during low-sodium intervention, increased during high-sodium intervention, and then decreased during potassium supplementation. We observed potential linear trends toward significance of central SBP and PP responses to low-sodium intervention, and significant linear trends of responses to high-sodium intervention as the number of metabolic traits grows. For example, among participants with 0 or 1, 2 or 3, and 4 or 5 metabolic traits, central SBP responses to high-sodium intervention were 8.8 [95% confidence interval (5.8, 11.8)], 9.3 (7.1, 11.6), and 14.0 (11.6, 16.3) mmHg, respectively (P for trend = 0.009). Significant linear trends of central SBP and DBP responses to potassium supplementation were also observed. CONCLUSIONS Central BP and AIx@75 were lowered by sodium reduction and potassium supplementation, and elevated by sodium-loading. The responses of central BP were pronounced among individuals with metabolic traits clustering. CLINICAL TRIALS REGISTRATION Trial Number NCT00721721 (The current study is registered on ClinicalTrials.gov; https://clinicaltrials.gov).

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Olsson, Leandro André Vieira, Juliana Paludo Vallandro, Giancarlo Bazarele Machado Bruno, and Elza Daniel De Mello. "Effect of lifestyle change on the management of metabolic syndrome and nonalcoholic fatty liver in adolescents: a systematic review / Efeito da mudança no estilo de vida no tratamento da síndrome metabólica e do fígado gorduroso não alcoólico em adolescentes: uma revisão sistemática." Brazilian Journal of Health Review 5, no. 2 (April 20, 2022): 7058–76. http://dx.doi.org/10.34119/bjhrv5n2-270.

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Objective: To evaluate the impact of interventions related to lifestyle change in the management of metabolic syndrome and nonalcoholic fatty liver disease in adolescents. Methods: Systematic review covering randomized clinical trials in adolescents aged 12 to 18 years with a diagnosis of metabolic syndrome and/or nonalcoholic fatty liver disease, with a minimum intervention period of three months. We included the Pubmed, Embase, and Cochrane databases. We included studies published in English, Spanish, Portuguese, Italian, French, German, and Swedish. Results and conclusion: A total of 1.676 articles were found and, after adequate evaluation, five articles considered relevant to the objective of this systematic review. Dietary interventions have been shown to be effective in weight reduction, BMI, lipid profile, and intrahepatic fat. In the form of aerobic training associated with resistance training, interventions in physical activity were effective in reducing the prevalence of nonalcoholic fatty liver disease. The high and low-intensity training resulted in the improvement of biomarkers related to the disease. In patients with risk factors for metabolic syndrome, dietary, psychological, and physical activity intervention reduced fat mass, lipid profile, and C-reactive protein. It is important to highlight the multidisciplinary role of interventions, demonstrating the importance of integrated care to adolescent health.

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DeJongh, Beth M. "Clinical pearls for the monitoring and treatment of antipsychotic induced metabolic syndrome." Mental Health Clinician 11, no. 6 (November 1, 2021): 311–19. http://dx.doi.org/10.9740/mhc.2021.11.311.

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Abstract Antipsychotic medications increase the risk of metabolic syndrome, which then increases the risk of atherosclerotic cardiovascular disease and premature death. Routinely monitoring for signs of metabolic syndrome in patients taking antipsychotics allows for early detection and intervention. Psychiatric pharmacists can improve patient care through metabolic syndrome monitoring and recommendation of appropriate interventions. Monitoring for the metabolic adverse effects of antipsychotics, management of weight gain, and management of lipids and blood pressure are explored through 2 patient cases.

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Augustus, Eden, Emily Haynes, Cornelia Guell, Karyn Morrissey, Madhuvanti M. Murphy, Cassandra Halliday, Lili Jia, Viliamu Iese, Simon G. Anderson, and Nigel Unwin. "The Impact of Nutrition-Based Interventions on Nutritional Status and Metabolic Health in Small Island Developing States: A Systematic Review and Narrative Synthesis." Nutrients 14, no. 17 (August 26, 2022): 3529. http://dx.doi.org/10.3390/nu14173529.

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Small island developing states (SIDS) have a high burden of nutrition-related disease associated with nutrient-poor, energy-dense diets. In response to these issues, we assessed the effectiveness of nutrition-based interventions on nutritional status (under-nutrition) and metabolic health (over-nutrition) among persons in SIDS. We included SIDS-based nutrition studies with change in nutrition status (e.g., markers of anaemia) or metabolic status (e.g., markers of glycaemia) as outcomes. The PRISMA framework was applied and MEDLINE, Embase, CINAHL, OARE library, Web of Science, Scopus, ASSIA, EconLit, AGORA, AGRICOLA, AGRIS, WHO-EMRO, and LILACS were searched (2000–2020). Cochrane risk of bias (ROB) and Cochrane ROBINS-I tools assessed ROB for randomised and non-randomised studies, respectively. PROSPERO registration (CRD42021236396) was undertaken. We included 50 eligible interventions, involving 37,591 participants: 14 trials reported on nutritional status, 36 on metabolic health. Effective interventions, evaluated at the individual level, took a multifaceted approach for metabolic outcomes; while nutrition outcomes utilised supplements. Most intervention types were suitable for issues related to ‘over’ nutrition versus ‘under’ nutrition. Twenty-six studies (nutrition status (six); metabolic health (twenty)) were effective (p < 0.05). With the current rise of nutrition-related public health challenges, there is a need for further development and evaluation of these and related interventions at the population level.

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Ferraz-Bannitz, Rafael, Rebeca A. Beraldo, A. Augusto Peluso, Morten Dall, Parizad Babaei, Rayana Cardoso Foglietti, Larissa Marfori Martins, et al. "Dietary Protein Restriction Improves Metabolic Dysfunction in Patients with Metabolic Syndrome in a Randomized, Controlled Trial." Nutrients 14, no. 13 (June 28, 2022): 2670. http://dx.doi.org/10.3390/nu14132670.

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Dietary restriction (DR) reduces adiposity and improves metabolism in patients with one or more symptoms of metabolic syndrome. Nonetheless, it remains elusive whether the benefits of DR in humans are mediated by calorie or nutrient restriction. This study was conducted to determine whether isocaloric dietary protein restriction is sufficient to confer the beneficial effects of dietary restriction in patients with metabolic syndrome. We performed a prospective, randomized controlled dietary intervention under constant nutritional and medical supervision. Twenty-one individuals diagnosed with metabolic syndrome were randomly assigned for caloric restriction (CR; n = 11, diet of 5941 ± 686 KJ per day) or isocaloric dietary protein restriction (PR; n = 10, diet of 8409 ± 2360 KJ per day) and followed for 27 days. Like CR, PR promoted weight loss due to a reduction in adiposity, which was associated with reductions in blood glucose, lipid levels, and blood pressure. More strikingly, both CR and PR improved insulin sensitivity by 62.3% and 93.2%, respectively, after treatment. Fecal microbiome diversity was not affected by the interventions. Adipose tissue bulk RNA-Seq data revealed minor changes elicited by the interventions. After PR, terms related to leukocyte proliferation were enriched among the upregulated genes. Protein restriction is sufficient to confer almost the same clinical outcomes as calorie restriction without the need for a reduction in calorie intake. The isocaloric characteristic of the PR intervention makes this approach a more attractive and less drastic dietary strategy in clinical settings and has more significant potential to be used as adjuvant therapy for people with metabolic syndrome.

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Nailufar, Farida, Ali Khomsan, Yayuk Farida Baliwati, and Hadi Riyadi. "The Effectiveness of Implementation of Healthy Living Community Movement in Overcoming Metabolic Syndrome Among Female Workers in East Kalimantan, Indonesia." Current Research in Nutrition and Food Science Journal 10, no. 3 (December 20, 2022): 1222–29. http://dx.doi.org/10.12944/crnfsj.10.3.34.

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The metabolic syndrome occurs in almost 25% of the world’s adult population. A workplace is an ideal place for implementing health interventions to reduce metabolic syndrome risk factor. One of the Indonesian government’s health programs to improve public health and prevent non-communicable diseases is called Healthy Living Community Movement (HLCM). This research aims to determine the effectiveness of HLCM implementation to overcome metabolic syndrome among female workers in Indonesia. This quasi-experimental study included 42 female workers with metabolic syndrome, which were divided into an intervention group and a control group. The intervention group was given an 8-weeks combination of health education and implementation of HLCM activities that consisted of fruit and vegetables provision as much as 400 grams per day and physical exercise for at least 150 minutes per week. The intervention for control group included only health education. Subjects’ parameters were measured and adherence to HLCM activities was evaluated by a questionnaire. Adherence to HLCM implementation was carried out by 52.4% of the subjects which resulted in a significant reduction in their waist circumference, systolic and diastolic blood pressure, and triglyceride levels (p < 0.05, respectively). After 8 weeks of interventions, 13 subjects (65%) from the intervention group were no longer included in the metabolic syndrome criteria, while in the control group only 2 subjects (10.5%) were not included. Therefore, the implementation of HLCM in the workplace is effective in overcoming the metabolic syndrome.

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Thor, Sze Mun, Jun Wern Yau, and Amutha Ramadas. "Nutritional and lifestyle intervention strategies for metabolic syndrome in Southeast Asia: A scoping review of recent evidence." PLOS ONE 16, no. 9 (September 14, 2021): e0257433. http://dx.doi.org/10.1371/journal.pone.0257433.

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Metabolic syndrome (MetS) is frequently associated with various health issues and is a major contributor to morbidity and mortality worldwide, particularly with its recent relevance to coronavirus disease 2019 (COVID-19). To combat its increasing prevalence in Southeast Asia, numerous intervention programs have been implemented. We conducted a scoping review on recent interventions to manage MetS among Southeast Asians using standard methodologies. Cochrane, Embase, Ovid MEDLINE, PubMed, and Scopus databases were systematically searched to yield peer-reviewed articles published between 2010–2020. We included 13 articles describing 11 unique interventions in four Southeast Asian countries: Malaysia, Thailand, Indonesia, and Vietnam. These interventions were broadly categorized into four groups: (i) nutrition (n = 4); (ii) physical activity (n = 2); (iii) nutrition and physical activity (n = 2); and (iv) multi-intervention (n = 3). Most studies investigated the effects of an intervention on components of MetS, which are anthropometry, blood pressure, glucose-related parameters, and lipid profile. Significant improvements ranged from 50% of studies reporting serum triglyceride and HDL-cholesterol levels to 100% for waist circumference. Evidence on interventions for individuals with MetS remains limited in Southeast Asia. More studies from other countries in this region are needed, especially on the effects of dietary interventions, to effectively address gaps in knowledge and provide sufficient data to design the ideal intervention for Southeast Asian populations.

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Leis, Rosaura, Carmela de Lamas, María-José de Castro, Rosaura Picáns, Mercedes Gil-Campos, and María L. Couce. "Effects of Nutritional Education Interventions on Metabolic Risk in Children and Adolescents: A Systematic Review of Controlled Trials." Nutrients 12, no. 1 (December 21, 2019): 31. http://dx.doi.org/10.3390/nu12010031.

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Childhood obesity is a global public health issue and is linked to metabolic syndrome, which increases the risk of comorbidities such as type 2 diabetes, cardiovascular diseases and cancer. Social, economic and cultural factors influence changes in nutrition and lifestyle characterized by poorer diets and reduced physical activity. This systematic review summarizes the evidence for nutritional education interventions to improve metabolic risks in children and adolescents. Systematic searches of the databases Medline (via PubMed) and Scopus were conducted following PRISMA guidelines. The risk of bias for each study was assessed following the methodology of the Cochrane Collaboration. Ten case-controlled and randomized controlled studies testing nutritional educational interventions targeting children and adolescents from the general population were eligible for inclusion. The sample size was 3915 and the age range was 7–20 years. The duration of intervention ranged from 12 weeks to 20 years. All the studies that provided data on abdominal obesity reported differences in favour of the intervention. However, data on the effects on the remaining components of metabolic syndrome remain inconclusive. These results support the role of nutritional education interventions as a strategy to reduce central adiposity and its possible unhealthy consequences in children and adolescents.

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van Greevenbroek, Marleen M. J., Casper G. Schalkwijk, and Coen D. A. Stehouwer. "Dysfunctional adipose tissue and low-grade inflammation in the management of the metabolic syndrome: current practices and future advances." F1000Research 5 (October 13, 2016): 2515. http://dx.doi.org/10.12688/f1000research.8971.1.

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The ongoing worldwide obesity epidemic makes the metabolic syndrome an increasingly important entity. In this review, we provide a short background on the metabolic syndrome, we discuss recent developments in the three main options that have been identified for intervention in the metabolic syndrome, i.e. lifestyle and surgical and pharmacological interventions, and we focus on different views in the literature and also include our own viewpoints on the metabolic syndrome. In addition, we discuss some emerging treatment targets for adipose tissue dysfunction and low-grade inflammation, i.e. activation of the inflammasome and the complement system, and consider some selected opportunities for intervention in these processes.

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Ribas-Aulinas, Francesc, Marcela Parra-Vargas, Marta Ramon-Krauel, Ruben Diaz, Carles Lerin, Trinitat Cambras, and Josep C. Jimenez-Chillaron. "Time-Restricted Feeding during Puberty Ameliorates Adiposity and Prevents Hepatic Steatosis in a Mouse Model of Childhood Obesity." Nutrients 13, no. 10 (October 13, 2021): 3579. http://dx.doi.org/10.3390/nu13103579.

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Background: Time restricted feeding (TRF) refers to dietary interventions in which food access is limited during a specific timeframe of the day. TRFs have proven useful in improving metabolic health in adult subjects with obesity. Their beneficial effects are mediated, in part, through modulating the circadian rhythm. Nevertheless, the translation of these dietary interventions onto obese/overweight children and adolescents remains uncharacterized. The objective of this study is to explore the feasibility of temporal dietary interventions for improving metabolic health in the context of childhood obesity. Methods: We have previously developed a mouse model of early adiposity (i.e., childhood obesity) through litter size reduction. Mice raised in small litters (SL) became obese as early as by two weeks of age, and as adults, they developed several obesity-related co-morbidities, including insulin resistance, glucose intolerance and hepatic steatosis. Here, we explored whether two independent short-term chrono-nutritional interventions might improve metabolic health in 1-month-old pre-pubertal SL mice. Both TRFs comprised 8 h feeding/14 h fasting. In the first one (TRF1) Control and SL mice had access to the diet for 8 h during the dark phase. In the second intervention (TRF2) food was available during the light:dark transitions. Results: TRF1 did not alter food intake nor ameliorate adiposity in SL-TRF1. In contrast, SL-TRF2 mice showed unintentional reduction of caloric intake, which was accompanied by reduced total body weight and adiposity. Strikingly, hepatic triglyceride content was completely normalized in SL-TRF1 and SL-TRF2 mice, when compared to the ad lib-fed SL mice. These effects were partially mediated by (i) clock-dependent signals, which might modulate the expression of Pparg or Cpt1a, and (ii) clock-independent signals, such as fasting itself, which could influence Fasn expression. Conclusions: Time-restricted feeding is an effective and feasible nutritional intervention to improve metabolic health, namely hepatic steatosis, in a model of childhood obesity. These data open new avenues for future safe and efficient chrono-nutritional interventions aimed to improve metabolic health in children with overweight/obesity.

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O’Sullivan, David, David E. Sanin, Edward J. Pearce, and Erika L. Pearce. "Metabolic interventions in the immune response to cancer." Nature Reviews Immunology 19, no. 5 (February 28, 2019): 324–35. http://dx.doi.org/10.1038/s41577-019-0140-9.

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Stemmer, Kerstin, Timo D. Müller, Richard D. DiMarchi, Paul T. Pfluger, and Matthias H. Tschöp. "CNS-targeting pharmacological interventions for the metabolic syndrome." Journal of Clinical Investigation 129, no. 10 (August 5, 2019): 4058–71. http://dx.doi.org/10.1172/jci129195.

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Shipman, Lydia. "Metabolic interventions repair CD4+ T cells in RA." Nature Reviews Rheumatology 12, no. 5 (April 15, 2016): 254. http://dx.doi.org/10.1038/nrrheum.2016.54.

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Ganzer, Nicole, Brandon Utter, Beth DeJongh, Michael Behrens, Guadalupe Garcia, and Rebecca Graham. "Re-implementation of a pharmacist-managed metabolic syndrome clinic in an outpatient mental health clinic setting." Mental Health Clinician 5, no. 1 (January 1, 2015): 57–62. http://dx.doi.org/10.9740/mhc.2015.01.057.

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Introduction: Second-generation antipsychotics (SGA) are often prescribed prior to first-generation antipsychotics (FGA) for mental health disorders by reason of proposed improved tolerability. Patients on SGA are not always appropriately screened for metabolic parameters in the clinical setting. A metabolic clinic was previously established for a limited time period at the West Palm Beach Veterans Affairs Medical Center (WPB VAMC) with beneficial outcomes. Re-implementation expanded the clinic to assess the impact when patients were referred from outpatient mental health and primary care providers. The objectives of this quality improvement initiative were to evaluate pharmacologic and nonpharmacologic interventions and compare the patient load preexpansion and postexpansion of the metabolic clinic. Methods: Patients receiving SGA at the WPB VAMC who met the criteria for metabolic syndrome were referred to the metabolic clinic. Preclinic data variables collected include demographics, social history, SGA, and assessment for presence of hypertension, diabetes, or dyslipidemia. Pharmacologic and nonpharmacologic intervention variables were collected throughout clinic involvement. The patient load post clinic expansion was reported. Results: Of the 17 patients evaluated, 88.2% had hypertension, 94.1% had dyslipidemia, and 88.2% had diabetes mellitus. The average number of components of metabolic syndrome was 3.7 out of 5 possible components. Most patients were taking risperidone (47.1%). An average of 1.5 medication interventions were made per patient. Only 28 patients were referred during reimplementation phase. Discussion: Metabolic syndrome commonly occurs in patients receiving SGA. Appropriately trained clinical pharmacists can help fill a gap in care by providing the recommended monitoring criteria and interventions for patients taking SGA.

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Elizabeth A J, Aruna S, and Mercy P J. "Effectiveness of reflexology related interventions on physiological and biochemical parameters of metabolic syndrome among women." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (January 18, 2020): 603–10. http://dx.doi.org/10.26452/ijrps.v11i1.1863.

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The purpose of the study was First to evaluate the effectiveness of reflexology related interventions on biochemical and physiological parameters of metabolic syndrome among women; Second to find out the association between physiological and biochemical parameters of metabolic syndrome among women with socio-demographic variables. The study used a true experimental design with one experimental group and one control group. Data were collected from 40 self-help group women who were the members of Kudumbashree from a selected area in South India. Samples were collected by using multistage sampling. Reflexology related intervention was given to the experimental group for 12 weeks. The control group did not receive an intervention. Repeated measures ANOVA and t-test were used for data analysis. The study found there is a significant change in the physiological and biochemical parameters of metabolic syndrome among the experimental group as compared to the control group (p<0.001). Even if there is no statistically significant difference between the different groups, the observed difference is clinically significant. The study concludes that reflexology related intervention was effective in improving the parameters of metabolic syndrome. It can be implemented in the clinical setting for patients with metabolic syndrome and related lifestyle disorders

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Myers, Jonathan, Peter Kokkinos, and Eric Nyelin. "Physical Activity, Cardiorespiratory Fitness, and the Metabolic Syndrome." Nutrients 11, no. 7 (July 19, 2019): 1652. http://dx.doi.org/10.3390/nu11071652.

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Both observational and interventional studies suggest an important role for physical activity and higher fitness in mitigating the metabolic syndrome. Each component of the metabolic syndrome is, to a certain extent, favorably influenced by interventions that include physical activity. Given that the prevalence of the metabolic syndrome and its individual components (particularly obesity and insulin resistance) has increased significantly in recent decades, guidelines from various professional organizations have called for greater efforts to reduce the incidence of this condition and its components. While physical activity interventions that lead to improved fitness cannot be expected to normalize insulin resistance, lipid disorders, or obesity, the combined effect of increasing activity on these risk markers, an improvement in fitness, or both, has been shown to have a major impact on health outcomes related to the metabolic syndrome. Exercise therapy is a cost-effective intervention to both prevent and mitigate the impact of the metabolic syndrome, but it remains underutilized. In the current article, an overview of the effects of physical activity and higher fitness on the metabolic syndrome is provided, along with a discussion of the mechanisms underlying the benefits of being more fit or more physically active in the prevention and treatment of the metabolic syndrome.

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Gromski, Mark A., and Shelby Sullivan. "Goals of therapy and concurrent lifestyle interventions to compliment endoscopic bariatric and metabolic interventions." Techniques and Innovations in Gastrointestinal Endoscopy 22, no. 3 (July 2020): 126–29. http://dx.doi.org/10.1016/j.tige.2020.03.004.

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Connaughton, Ruth M., Aoibheann M. McMorrow, Fiona C. McGillicuddy, Fiona E. Lithander, and Helen M. Roche. "Impact of anti-inflammatory nutrients on obesity-associated metabolic-inflammation from childhood through to adulthood." Proceedings of the Nutrition Society 75, no. 2 (March 3, 2016): 115–24. http://dx.doi.org/10.1017/s0029665116000070.

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Obesity-related metabolic conditions such as insulin resistance (IR), type 2 diabetes and CVD share a number of pathological features, one of which is metabolic-inflammation. Metabolic-inflammation results from the infiltration of immune cells into the adipose tissue, driving a pro-inflammatory environment, which can induce IR. Furthermore, resolution of inflammation, an active process wherein the immune system counteracts pro-inflammatory states, may be dysregulated in obesity. Anti-inflammatory nutritional interventions have focused on attenuating this pro-inflammatory environment. Furthermore, with inherent variability among individuals, establishing at-risk populations who respond favourably to nutritional intervention strategies is important. This review will focus on chronic low-grade metabolic-inflammation, resolution of inflammation and the putative role anti-inflammatory nutrients have as a potential therapy. Finally, in the context of personalised nutrition, the approaches used in defining individuals who respond favourably to nutritional interventions will be highlighted. With increasing prevalence of obesity in younger people, age-dependent biological processes, preventative strategies and therapeutic options are important to help protect against development of obesity-associated co-morbidities.

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Pham, Thi Van Anh, Duc Cuong Le, and Thi Nhung Ninh. "Effectiveness of some dietary and lifestyle interventions for metabolic syndrome in people aged 25-64 years old in Thai Binh province." Ministry of Science and Technology, Vietnam 64, no. 12 (December 25, 2022): 19–23. http://dx.doi.org/10.31276/vjst.64(12).19-23.

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The study aimed to assess the effectiveness of interventions on metabolic syndrome (MetS) in 184 people aged 25-64 years old in 4 communes of Thai Binh province from August 2020 to January 2021. Results after the intervention by means of communication, diet, and exercise showed that after the interventions the prevalence of MetS decrease from 100 to 63.7%, and the intervention effectiveness was 13.7%. The mean of MetS components decreased by 0.63±0.10. Comparing the blood indexes before and after the intervention, the mean of glucose decreased by 0.36±0.17 mmol/l, the mean of high density lipoprotein cholesterol (HDL-C) increased by 0.126±0.047 mmol/l, and the mean of triglyceride decreased by 0.25±0.12 mmol/l. Interventions have the effect of reducing the syndrome rate and its components.

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Davis, Jaimie N., Emily E. Ventura, Gabriel Q. Shaibi, Courtney E. Byrd-Williams, Katharine E. Alexander, Amanda K. Vanni, Mathew R. Meija, Marc J. Weigensberg, Donna Spruijt-Metz, and Michael I. Goran. "Interventions for improving metabolic risk in overweight Latino youth." International Journal of Pediatric Obesity 5, no. 5 (October 2010): 451–55. http://dx.doi.org/10.3109/17477161003770123.

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Akash, Muhammad Sajid Hamid, Fareeha Fiayyaz, Kanwal Rehman, Shakila Sabir, and Muhammad Hidayat Rasool. "Gut Microbiota and Metabolic Disorders: Advances in Therapeutic Interventions." Critical Reviews in Immunology 39, no. 4 (2019): 223–37. http://dx.doi.org/10.1615/critrevimmunol.2019030614.

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Grover, Sunita, RashmiH Mallappa, Namita Rokana, RajKumar Duary, Harsh Panwar, and VirenderKumar Batish. "Management of metabolic syndrome through probiotic and prebiotic interventions." Indian Journal of Endocrinology and Metabolism 16, no. 1 (2012): 20. http://dx.doi.org/10.4103/2230-8210.91178.

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Papanastasiou, Evangelos. "Interventions for the metabolic syndrome in schizophrenia: a review." Therapeutic Advances in Endocrinology and Metabolism 3, no. 5 (September 7, 2012): 141–62. http://dx.doi.org/10.1177/2042018812458697.

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Castedo, Maria, Florine Obrist, and Guido Kroemer. "Cisplatin resistance coupled to enhanced sensitivity to metabolic interventions." Molecular & Cellular Oncology 5, no. 6 (October 10, 2018): e1526004. http://dx.doi.org/10.1080/23723556.2018.1526004.

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Godfrey, M. D., R. W. Braith, T. Kaminsky, and B. R. Stevens. "QUANTIFICATION OF EXHAUSTIVE MUSCLE FUNCTION FOLLOWING ISOCALORIC METABOLIC INTERVENTIONS." Medicine & Science in Sports & Exercise 30, Supplement (May 1998): 70. http://dx.doi.org/10.1097/00005768-199805001-00397.

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