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Статті в журналах з теми "Mesoporous bioactive glasse"
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Migneco, Carla, Elisa Fiume, Enrica Verné, and Francesco Baino. "A Guided Walk through the World of Mesoporous Bioactive Glasses (MBGs): Fundamentals, Processing, and Applications." Nanomaterials 10, no. 12 (December 21, 2020): 2571. http://dx.doi.org/10.3390/nano10122571.
Повний текст джерелаАнотація:
Bioactive glasses (BGs) are traditionally known to be able to bond to living bone and stimulate bone regeneration. The production of such materials in a mesoporous form allowed scientists to dramatically expand the versatility of oxide-based glass systems as well as their applications in biomedicine. These nanostructured materials, called mesoporous bioactive glasses (MBGs), not only exhibit an ultrafast mineralization rate but can be used as vehicles for the sustained delivery of drugs, which are hosted inside the mesopores, and therapeutic ions, which are released during material dissolution in contact with biological fluids. This review paper summarizes the main strategies for the preparation of MBGs, as well as their properties and applications in the biomedical field, with an emphasis on the methodological aspects and the promise of hierarchical systems with multiscale porosity.
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Zhao, Yu Feng, and Jan Ma. "Mesoporous Bioactive Glasses: Synthesis, Characterization and In Vitro Bioactivity." Journal of Biomimetics, Biomaterials and Tissue Engineering 1 (July 2008): 37–47. http://dx.doi.org/10.4028/www.scientific.net/jbbte.1.37.
Повний текст джерелаАнотація:
In this work, two systems of mesoporous bioactive glasses (MBGs) with a series of different SiO2:CaO:P2O5 ratios were derived via a sol-gel method involving the usage of block copolymers Pluronic F127 and P123 as templates, respectively. A two-dimensional hexagonal (P6mm) mesoporous structure was obtained in the two systems with a SiO2:CaO:P2O5 ratio of 80:16:4. With the decrease of the SiO2 content, the porous structure of MBGs became less regular, and the BET surface area and the pore volume were also decreased. Mesoporous bioactive glasses from the template F127 displayed a higher degree of bioactivity than those from the template P123, as a result of the existence of more defects on the walls of the mesopores.
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Phetnin, Ratiya, and Sirirat Tubsungnoen Rattanachan. "Bio-Hybrid Composite Scaffold from Silk Fibroin/Chitosan/Mesoporous Bioactive Glass Microspheres for Tissue Engineering Applications." Advanced Materials Research 1131 (December 2015): 79–83. http://dx.doi.org/10.4028/www.scientific.net/amr.1131.79.
Повний текст джерелаАнотація:
This research aims to fabricate the novel bio-hybrid composite scaffold from mesoporous bioactive glasses/silk fibroin/chitosan (MBGs/SF/CS) for use in tissue engineering applications. MBGs/SF/CS composite scaffolds were successfully fabricated using freezing and lyophilization process. Two types of mesoporous bioactive glasses which were irregular and spherical shape were dispersed in the silk fibroin/chitosan based scaffolds in order to improve the mechanical strength and bioactivity. SEM observation showed the interconnected pores with pore size from 100 to 300 µm. XRD and FTIR exhibited the present of silk fibroin, chitosan, and MBGs in composite scaffolds. The incorporation of MBGs in SF/CS scaffolds significantly increased the compressive strength of scaffolds. The composite scaffolds were immersed in the simulated body fluid (SBF) for in vitro bioactivity test. The in vitro bioactivity results indicated that the MBGs/SF/CS induced hydroxycarbonate apatite (HCA) formation while there was no change for SF/CS scaffolds. Furthermore, mesoporous bioactive glass with micro-spherical particles (MBGMs) which easily dispersed in SF/CS solution during the fabrication of scaffolds as compared to mesoporous bioactive glass with irregular shape (MBGs). The results showed that MBGs/SF/CS composite scaffolds could be useful composite scaffolds for tissue engineering applications.
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Liu, Jiawei, Guo Du, Hongda Yu, Xueyin Zhang, and Tiehong Chen. "Synthesis of Hierarchically Porous Bioactive Glass and Its Mineralization Activity." Molecules 28, no. 5 (February 27, 2023): 2224. http://dx.doi.org/10.3390/molecules28052224.
Повний текст джерелаАнотація:
Mesoporous bioactive glass is a promising biomaterial for bone tissue engineering due to its good biocompatibility and bioactivity. In this work, we synthesized a hierarchically porous bioactive glass (HPBG) using polyelectrolyte-surfactant mesomorphous complex as template. Through the interaction with silicate oligomers, calcium and phosphorus sources were successfully introduced into the synthesis of hierarchically porous silica, and HPBG with ordered mesoporous and nanoporous structures was obtained. The morphology, pore structure and particle size of HPBG can be controlled by adding block copolymer as co-template or adjusting the synthesis parameters. The ability to induce hydroxyapatite deposition in simulated body fluids (SBF) demonstrated the good in vitro bioactivity of HPBG. Overall, this work provides a general method for the synthesis of hierarchically porous bioactive glasses.
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Muhammad Ikram, Shabbir Hussain, and Mohsin Javed. "Nature and Therapeutic Potential of Silica-based Mesoporous Bioactive Glass." Scientific Inquiry and Review 3, no. 2 (June 5, 2019): 17–26. http://dx.doi.org/10.32350/sir.32.03.
Повний текст джерелаАнотація:
Bioactive materials have received much consideration in the last couple of years because of their astounding properties in various fields. Bioactive Glasses (BGs) are utilized as part of biomedical applications, such as antibacterial materials. BGs can be delivered by means of dissolve extinguishing strategy or sol-gel technique. Bactericidal silver-doped sol-gel inferred mesoporous silica-based bioactive glasses were accounted for the first time in 2000, having the synthesis 76SiO2-19CaO-2P2O5-3Ag2O (wt%) and a mean pore width of 28 nm. Bioactive glasses doped with metallic elements such as silver, copper, zinc, cerium and gallium are the focus of this audit in which SiO2, SiO2-CaO and SiO2-CaO-P2O5 frameworks are incorporated as the parent glass creations. Run of the mill uses of mesoporous BGs doped with antibacterial particles incorporate bone tissue recovery, multifunctional earthenware coatings for orthopedic gadgets and orbital inserts, scaffolds with upgraded angiogenesis potential, osteostimulation and antibacterial properties for the treatment of various bone imperfections and also in wound recuperating.
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Kermani, Farzad, Hossein Sadidi, Ali Ahmadabadi, Seyed Javad Hoseini, Seyed Hasan Tavousi, Alireza Rezapanah, Simin Nazarnezhad, Seyede Atefe Hosseini, Sahar Mollazadeh, and Saeid Kargozar. "Modified Sol–Gel Synthesis of Mesoporous Borate Bioactive Glasses for Potential Use in Wound Healing." Bioengineering 9, no. 9 (September 5, 2022): 442. http://dx.doi.org/10.3390/bioengineering9090442.
Повний текст джерелаАнотація:
In this study, we successfully utilized nitrate precursors for the synthesis of silver (Ag)-doped borate-based mesoporous bioactive glass (MBGs) based on the 1393B3 glass formulation in the presence of a polymeric substrate (polyvinyl alcohol (PVA)) as a stabilizer of boric acid. The X-ray diffraction (XRD) analysis confirmed the glassy state of all the MBGs. The incorporation of 7.5 mol% Ag into the glass composition led to a decrease in the glass transition temperature (Tg). Improvements in the particle size, zeta potential, surface roughness, and surface area values were observed in the Ag-doped MBGs. The MBGs (1 mg/mL) had no adverse effect on the viability of fibroblasts. In addition, Ag-doped MBGs exhibited potent antibacterial activity against gram-positive and gram-negative species. In summary, a modified sol–gel method was confirmed for producing the Ag-doped 1393B3 glasses, and the primary in vitro outcomes hold promise for conducting in vivo studies for managing burns.
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Son, Sung-Ae, Dong-Hyun Kim, Kyung-Hyeon Yoo, Seog-Young Yoon, and Yong-Il Kim. "Mesoporous Bioactive Glass Combined with Graphene Oxide Quantum Dot as a New Material for a New Treatment Option for Dentin Hypersensitivity." Nanomaterials 10, no. 4 (March 27, 2020): 621. http://dx.doi.org/10.3390/nano10040621.
Повний текст джерелаАнотація:
Dentin hypersensitivity is one of the most common clinical conditions usually associated with exposed dentinal tubules. The purpose of this study was to identify the potential of a graphene oxide quantum dot coating for mesoporous bioactive glass nanoparticles as a new material for the treatment of dentin hypersensitivity by investigating its mineralization activity and dentinal tubules sealing. Mesoporous bioactive glass nanoparticle was fabricated by modified sol-gel synthesis. X-ray diffraction was performed to characterize the synthesized nanoparticle Fourier transform infra-red spectroscopy investigated the functionalized surfaces. The distribution of the specific surface area and the pore size was measure by Pore size analysis. The morphology of sample was observed by Field Emission Scanning Electron Microscope (FESEM) and Field Emission Transmission Electron Microscope (FETEM). After disk-shaped specimens of mesoporous bioactive glass nanoparticles and graphene oxide quantum dot coated mesoporous bioactive glass nanoparticles (n = 3) were soaked in the simulated body fluid for 0, 1, 5, 10,and 30 days, the amount of ions released was observed to confirm the ionic elution for mineralization. Sensitive tooth model discs (n = 20) were applied with two samples and evaluated the dentinal tubule sealing ability. The spherical mesoporous bioactive glass nanoparticles and graphene oxide quantum dot coated mesoporous bioactive glass nanoparticles with a diameter of about 500 nm were identified through FESEM and FETEM. The ion release capacity of both samples appeared to be very similar. The amount of ion released and in vitro mineralization tests confirmed that graphene oxide quantum dot coating of mesoporous bioactive glass nanoparticles did not inhibit the release of calcium, silicon and phosphate ions, but rather that graphene oxide quantum dot promoted hydroxyapatite formation. In the FESEM image of the sensitive tooth disc surface, it was observed that graphene oxide quantum dot coated mesoporous bioactive glass nanoparticles sealed tightly the dentinal tubules. The graphene oxide quantum dot coating of mesoporous bioactive glass nanoparticles not only showed the excellent dentinal sealing ability but also rapidly promoted mineralization while minimizing the size increase by coating the mesoporous bioactive glass nanoparticles.
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Salinas, Antonio J., and Maria Vallet-Regí. "The Sol–Gel Production of Bioceramics." Key Engineering Materials 391 (October 2008): 141–58. http://dx.doi.org/10.4028/www.scientific.net/kem.391.141.
Повний текст джерелаАнотація:
Sol–gel synthesis is used for the fabrication of new materials with technological applications including ceramics for implants manufacturing, usually termed bioceramics. Many bioactive and resorbable bioceramics, that is, calcium phosphates, glasses and glass–ceramics, have been improved by using the sol–gel synthesis. In addition, the soft thermal conditions of sol–gel methods made possible to synthesize more reactive materials than those synthesized by traditional methods. Moreover, new families of bioactive materials such as organic–inorganic hybrids and inorganic compounds with ordered mesostructure can be produced. In hybrid materials, the inorganic component ensures the bioactive response whereas the organic polymeric component allows modulating other properties of the resulting biomaterial such as mechanical properties, degradation, etc. On the other hand, the sol–gel processes also allow the synthesis of silica ordered mesoporous materials, which are bioactive and exhibit – as an added value – a possible application as matrices for the controlled release of biologically active molecules (drugs, peptides, hormones, etc.). Finally, by combining the bioactive glasses composition with synthesis strategies of mesoporous materials, template glasses with ordered mesoporosity can be obtained. In this chapter, the advances that sol–gel technology has brought to the silica-based bioactive bioceramics are presented.
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Schmitz, Seray, Ana M. Beltrán, Mark Cresswell, and Aldo R. Boccaccini. "A Structural Comparison of Ordered and Non-Ordered Ion Doped Silicate Bioactive Glasses." Materials 13, no. 4 (February 22, 2020): 992. http://dx.doi.org/10.3390/ma13040992.
Повний текст джерелаАнотація:
One of the key benefits of sol-gel-derived glasses is the presence of a mesoporous structure and the resulting increase in surface area. This enhancement in textural properties has a significant effect on the physicochemical properties of the materials. In this context the aim of this study was to investigate how sol-gel synthesis parameters can influence the textural and structural properties of mesoporous silicate glasses. We report the synthesis and characterization of metal ion doped sol-gel derived glasses with different dopants in the presence or absence of a surfactant (Pluronic P123) used as structure-directing templating agent. Characterization was done by several methods. Using a structure directing agent led to larger surface areas and highly ordered mesoporous structures. The chemical structure of the non-ordered glasses was modified to a larger extent than the one of the ordered glasses due to increased incorporation of dopant ions into the glass network. The results will help to further understand how the properties of sol-gel glasses can be controlled by incorporation of metal dopants, in conjunction with control over the textural properties, and will be important to optimize the properties of sol-gel glasses for specific applications, e.g., drug delivery, bone regeneration, wound healing, and antibacterial materials.
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Salinas, Antonio J., and Pedro Esbrit. "Mesoporous Bioglasses Enriched with Bioactive Agents for Bone Repair, with a Special Highlight of María Vallet-Regí’s Contribution." Pharmaceutics 14, no. 1 (January 15, 2022): 202. http://dx.doi.org/10.3390/pharmaceutics14010202.
Повний текст джерелаАнотація:
Throughout her impressive scientific career, Prof. María Vallet-Regí opened various research lines aimed at designing new bioceramics, including mesoporous bioactive glasses for bone tissue engineering applications. These bioactive glasses can be considered a spin-off of silica mesoporous materials because they are designed with a similar technical approach. Mesoporous glasses in addition to SiO2 contain significant amounts of other oxides, particularly CaO and P2O5 and therefore, they exhibit quite different properties and clinical applications than mesoporous silica compounds. Both materials exhibit ordered mesoporous structures with a very narrow pore size distribution that are achieved by using surfactants during their synthesis. The characteristics of mesoporous glasses made them suitable to be enriched with various osteogenic agents, namely inorganic ions and biopeptides as well as mesenchymal cells. In the present review, we summarize the evolution of mesoporous bioactive glasses research for bone repair, with a special highlight on the impact of Prof. María Vallet-Regí´s contribution to the field.
Дисертації з теми "Mesoporous bioactive glasse"
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Yuen, Jones. "Preparation, characterisation and in vivo osteogenesis of mesoporous bioactive glasses." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/53101/1/Jones_Yuen_Thesis.pdf.
Повний текст джерелаАнотація:
Bone defects, especially large bone defects, remain a major challenge in orthopaedic surgery. Autologous bone transplantation is considered the most effective treatment, but insufficient donor tissue, coupled with concerns about donor site morbidity, has hindered this approach in large-scale applications. Alternative approaches include implanting biomaterials such as bioactive glass (BG), which has been widely used for bone defect healing, due to having generally good biocompatibility, and can be gradually biodegraded during the process of new bone formation. Mesoporous bioactive glass (MBG) is a newly developed bioactive glass which has been proven to have enhanced in-vitro bioactivity; however the in-vivo osteogenesis has not been studied. A critical problem in using the bone tissue engineering approach to restore large bone defects is that the nutrient supply and cell viability at the centre of the scaffold is severely hampered since the diffusion distance of nutrients and oxygen for cell survival is limited to 150-200µm. Cobalt ions has been shown to mimic hypoxia, which plays a pivotal role in coupling angiogenesis with osteogenesis in-vivo by activating hypoxia inducing factor-1α (HIF-1α) transcription factor, subsequently initiating the expression of genes associated with tissue regeneration. Therefore, one aim of this study is to investigate the in-vivo osteogenesis of MBG by comparison with BG and β-TCP, which are widely used clinically. The other aim is to explore hypoxia-mimicking biomaterials by incorporating Cobalt into MBG and β-TCP. MBG and β-TCP incorporated with 5% cobalt (5Co-MBG and 5CCP) have also been studied in-vivo to determine whether the hypoxic effect has a beneficial effect on the bone formation. The composition and microstructure of synthesised materials (BG, MBG, 5Co-MBG, 5CCP) were characterised, along with the mesopore properties of the MBG materials. Dissolution and cytotoxicity of the Co-containing materials were also investigated. Femoral samples with defects harvested at 4 and 8 weeks were scanned using micro-CT followed by processing for histology (H&E staining) to determine bone formation.
Histology of MBG showed a slower rate of bone formation at 4 weeks than BG, however at 8 weeks it could be clearly seen that MBG had more bone formation. The in-vivo results show that the osteogenesis of MBG reciprocates the enhanced performance shown in-vitro compared to BG. Dissolution study showed that Co ions can be efficiently released from MBG and β-TCP in a controllable way. Low amounts of Co incorporated into the MBG and β-TCP showed no significant cytotoxicity and the Co-MBG powders maintained a mesopore structure although not as highly ordered as pure MBG. Preliminary study has shown that Co incorporated samples showed little to no bone formation, instead incurring high lymphocyte activity. Further studies need to be done on Co incorporated materials to determine the cause for high lymphocyte activity in-vivo, which appear to hinder bone formation. In conclusion, this study demonstrated the osteogenic activity of MBG and provided some valuable information of tissue reaction to Co-incorporated MBG and TCP materials.
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Fan, J. P. "Mesoporous bioactive glass and alginate composite scaffolds for tissue engineering." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1443622/.
Повний текст джерелаАнотація:
Sol-gel derived, silica-based bioactive glasses of a ternary system (SiO₂ – CaO – P₂O₅) has the potential to promote hard and soft tissue regeneration. Compared to melt-derived glasses, glasses synthesised from the sol-gel process has the advantage of low processing temperatures, high specific surface areas (SSA) and tailorable porous nanostructures. Using scaffolds as a strategy for tissue engineering, the application of sol-gel derived bioactive glasses in combination with alginate polymers as scaffold composite materials has great potential and therefore requires further study. This thesis investigates the synthesis of bioactive glasses via the sol-gel (acidic) route and the multi-step (alkali) route, through the sol → drying → sintering stages. Sol-gel route nanoparticles derived were heterogeneous in shape, while the multi-step route produced spherical (30 – 90 nm diameter) nanoparticles. Increases in calcium content of the sol led to an increase in pore size and a decrease in SSA. Three dehydration methods: oven, vacuum and freeze drying were devised to control the morphology of nanoparticles. Freeze dried nanoparticles were found to have a rough surface texture, with an aligned ordered porous nanostructure. This led to faster apatite formation when compared to oven dried nanoparticles immersed in simulated body fluid (SBF). A novel internal ionic diffusion cross-linking method of alginate was developed, utilising the glass nanoparticles as nanocarriers, for the synthesis of alginate-bioactive glass composite scaffolds. Strontium chloride (SrCl₂) and copper chloride (CuCl₂), which provided therapeutic ions, were impregnated into the nanocarriers, and were compared to calcium chloride (CaCl₂), as the control. Impregnation efficiency was in the order of CuCl₂ > SrCl₂ ≈ CaCl₂, attributed to Cu²⁺ having the smallest ionic radii and its interaction with silinol groups on the nanocarrier surfaces. Scaffold gelation time was correlated to the type of cross-linking salt, its loading concentration and glass to alginate (G/A) ratio. It was observed that SrCl₂ loaded nanocarriers (BGSr) were most efficient in cross-linking when compared to CuCl₂ and CaCl₂ loaded nanocarriers (BGCu and BGCa respectively), due to Sr²⁺ having a greater affinity towards alginate. Results showed that nanocarriers with the highest SSA possessed the highest impregnation efficiency; however nanocarriers with the largest pore diameter and volume led to the fastest scaffold gelation time. BGCa and BGSr scaffolds showed significant improvements in maintaining stiffness (Young’s modulus) and shear resistance (maximum shear stress) after incubation in aqueous solutions for up to 28 days, which were in contrast to the deterioration in mechanical properties of conventional CaCl₂ cross-linked scaffolds. Calcium ions were detected in the range above 260 ppm in BGCa nanocarrier supernatant, suggesting the gradual release of ions from the nanocarriers, internally diffusing into the scaffold matrix, leading to continuous cross-linking over time. Meanwhile, in vitro biological studies showed fast apatite formation on BGCa cross-linked scaffolds in SBF, with the scaffolds capable of supporting the attachment, growth and proliferation of human osteoblast cells, thus indicating their high bioactivity. Control over glass nanoparticle morphology was achieved and through specific ionic impregnation, the successful synthesis of alginate-bioactive glass composite scaffolds was demonstrated, producing bioactive scaffolds with improved mechanical properties.
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Fernando, Jesu Delihta Liyaa. "Novel Mesoporous Bioactive Glasses (MBGs) as fillers in dental adhesives « Synthesis, Physico-chemical and biological evaluation »." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1072/document.
Повний текст джерелаАнотація:
Améliorer la stabilité de l’interface dentine adhésif est primordial si on veut prolonger la durée de vie et la longévité des restaurations en composite. La reminéralisation utilisant des matériaux relarguant des ions semble etre une approche prometteuse pour protéger la couche hybride de la dégradation hydrolytique et enzymatique. Les verres bioactifs mésoporeux (MBG) présentent des caractéristiques de surface intéressantes qui permettent de les utiliser comme charges au sein de l’adhésif qui favorisent d’une part la reminéralisation par la libération d’ions, d’autre part la fonctionnalisation des pores par des médicaments antibactériens. Ces caractéristiques permettent de lutter contre la reprise de carie. Le présent travail porte sur la synthèse et l'évaluation de nouveaux MBG pouvant être utilisés comme charges dans les adhésifs dentaires. Les MBG ont été préparés dans un système sol-gel à base d'acétate avec des précurseurs industriellement sûrs et non toxiques. Les MBG préparés à grande échelle (50g) offrent des caractéristiques de surface améliorées par rapport aux MBG à petite échelle (10g). L'étude de l'influence des modificateurs de réseau (CaO: Na2O) sur les caractéristiques de surface des MBG a révélé que la porosité était influencée par la teneur en CaO dans la composition. Une surface spécifique très élevée (535 m2g-1) et un volume de pores (0,33 cm3) ont été atteints dans le MBG avec la plus forte teneur en CaO. Par la suite, l'ordre de l'effet d'addition des précurseurs sur les caractéristiques de surface des MBG a été étudié. En maintenant la composition fixée et en faisant varier l'ordre d'addition du précurseur pendant la synthèse sol-gel, on a obtenu une augmentation de 1,5 fois du volume des pores et une diminution de 1,2 fois de la taille moyenne des pores. La méthode démontrée est une voie simple et directe pour améliorer la porosité et l'homogénéité des MBG. De plus, la modulation de la taille moyenne des pores pour une composition fixe est également utile pour une éventuelle application d’administration de médicament. En ce qui concerne la bioactivité, les charges de MBG ayant la plus forte teneur en CaO ont augmenté le précipité de phosphate de calcium dans le SBF après 7 jours, par opposition au MBG avec une teneur élevée en Na2O. De plus, tous les échantillons testés étaient non cytotoxiques pour les fibroblastes gingivaux humains (HGF) in vitro. De manière positive, les MBG traités à basse température ont significativement augmenté l'activité métabolique des HGF. Le broyage à boulets a été utilisé pour réduire la taille des particules primaires de MBG à moins de 3 µm. Le fraisage a visiblement eu un effet néfaste sur la porosité des charges MBG. Néanmoins, une certaine porosité est restée. L'adhésif commercial a été mélangé avec 3, 10, 20 et 30% en poids de charge MBG. L'adhésif rempli de MBG jusqu'à 10% en poids de charge a une viscosité fluide compatible avec l’application d'un adhésif. Le MBG ainsi développé avec une haute porosité et un contenu en CaO représentent des charges prometteuses pour des futures applications en dentisterie restaurative et régénérativeImproving the stability of adhesive dentin interface is crucial to extend the longevity of composite restorations. Remineralization through use of ion releasing materials is a promising approach to protect the hybrid layer from hydrolytic and enzymatic degradation. Mesoporous bioactive glasses (MBGs) offer attractive surface features (enhanced surface area and porosity) to use them as fillers in dental adhesives to promote remineralization through ions release. Moreover, the functionalization of pores with antibacterial drugs is a good way to combat secondary caries. The present work focused on the synthesis and evaluation of novel MBGs suitable to be used as fillers in dental adhesives. The MBGs were prepared in an acetate based sol-gel system with industrially safe and non-toxic precursors. MBGs prepared in large scale (50g) offered enhanced surface characteristics in comparison to small scale (10g) MBGs. The investigation on the influence of network modifiers (CaO:Na2O) on the surface characteristics of MBGs revealed that the porosity was driven by CaO content in the composition. Notable, very high surface area (535m2g-1) and pore volume (0.33cm3g-1) was attained in the MBG with highest CaO content. Next, the order of precursor addition effect on the surface characteristics of MBGs has been studied. By Keeping the composition fixed and varying the order of precursor addition during sol-gel synthesis a doubling of surface area, 1.5 times increase in pore volume and 1.2 times decrease in mean pore size was obtained. The demonstrated method is a simple and straightforward route to improve the porosity and homogeneity of MBGs. Furthermore, modulation of mean pore size for a fixed composition is also useful to tailor the pores of the fillers for drug delivery application. With regards to bioactivity, the MBG fillers with highest CaO content had increased calcium phosphate precipitate in SBF after 7 days as opposed to MBG with high Na2O content. Furthermore, all tested samples were non-cytotoxic to Human Gingival Fibroblasts (HGFs) in vitro. Positively, MBGs treated at lower temperature significantly enhanced the metabolic activity of HGFs. Ball milling was employed to reduce the primary particle size of MBG to less than 3μm. Milling seemingly had an adverse effect on the porosity of the MBG filler. Nevertheless, some porosity remained. The commercial adhesive was mixed with 3, 10, 20 and 30 weight percentage of MBG filler. MBG filled adhesive up to10 weight percent filler content had flowable viscosity suitable for adhesive application. The developed MBG with high porosity and CaO content appears as a new step in the development of dental adhesives and also other bioactive dental materials
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Yu, Jing-Lun, and 余境倫. "Preparation and characterization of mesoporous bioactive glass fibrous microspheres." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/a89yuw.
Повний текст джерела
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翁如春. "Preparation and characterization of mesoporous bioactive glass nanofibrous matrix." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/99640272113840962284.
Повний текст джерела
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Lin, Yi-Hsuan, and 林奕萱. "Preparation of mesoporous bioactive glass/polycaprolactone nanofibrous matrix and the effect of mesoporous bioactive glass on the characteristics of MG63 osteoblast－like cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/70014453684660642454.
Повний текст джерелаАнотація:
碩士國立臺灣海洋大學
生物科技研究所
99
Polycaprolactone (PCL) is a biodegradable polymer, and it has recently attracted much interest because of its cost efficiency and high toughness as bone tissue engineering scaffold. However, it lacks hydrophilicity and bioactivity. Mesoporous bioactive glass (MBG) has been used for bone tissue engineering due to their reported superior bone-forming bioactivity. The electrospinning technique is a convenient method for production of ultra-thin fibers with diameters ranging from submicrons to a few nanometers. In this study, we utilized an electrospinning fabrication process for the production of nanofibrous matrix that is composed of PCL and MBG. The mean diameter of the composite nanofibrous matrix was approximately 300 nm, this dimension is similar to that of native fibrous protein within the extracellular matrix (ECM). Moreover, we explored the effects of MBG on the hydrophilicity, mechanical strength, bioactivity and cellular response. From the data, MBG/PCL nanofiberous matrix exhibited a significantly improved surface hydrophilicity compared to PCL nanofibrous matrix. The bone-forming bioactivity of matrix was evaluated by soaking the matrix in a simulated body fluid. We could find the MBG/PCL nanofibrous matrix induced a layer of hydroxyapatite in a simulated body fluid at 7 days. The hydroxyapatite crystals were similar in composition to human bone mineral via SEM, X-ray diffraction, EDX analysis and ATR-FTIR. Finally, The cellular attachment rate, proliferation, differentiation and mineralization activity of MG63 osteoblast-like cells were significantly higher for MBG/PCL nanofibrous matrix than for PCL nanofibrous matrix. In addition, with regard to the osteoblast gene and protein ability, we observed that Real-time PCR and western blotting of MG63 cells on the MBG/PCL nanofibrous matrix higher than on the PCL nanofibrous matrix. This indicated that MBG/PCL nanofibrous matrix could potentially be used as a bone graft for bone regeneration.
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Kusriantoko, Parindra, and Parindra Kusriantoko. "Degradation behavior and bioactivity of various compositional mesoporous bioactive glasses." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/60632792522965831264.
Повний текст джерелаАнотація:
碩士國立臺灣科技大學
材料科學與工程系
103
Spray pyrolysis has been successfully used to synthesize mesoporous bioactive glasses (MBGs) with different compositions of SiO2-CaO-P2O5. In this study, the degradability and bioactivity of 58S, 68S and 76S MBG samples were studied. Simulated body fluid (SBF) solution was used as a medium to conduct the degradation test and also bioactivity for 30 days. The weight loss of MBG bulks were measured every day during the in-vitro degradation test. The pH value changes in SBF solution was also monitored every day in order to know the reaction that may occur in SBF solution. Some characterization methods, including x-ray diffraction analysis (XRD), fourier transform infrared (FTIR), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) have been used to know the phase changes, chemical bonding, surface morphology and compositional analysis respectively. In this research, the effect of composition on the degradation behavior and bioactivity were discussed. Since the degradation behavior of MBG was correlated to the apatite conversion. Furthermore, the mechanism of biodegradability on MBG to apatite conversion was also investigated. 58S MBG had the high degradation rate followed by 68S and 76S respectively. 68S and 76S MBG had ability to form apatite phase with 1 day of immersion while 58S MBG required 3 days of immersion.
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Lu, Pei-Shan, and 呂沛珊. "Bone-regenerative Mesoporous Bioactive Glasses Scaffold with Drug Controlled Release." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/09616899695926131384.
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碩士高雄醫學大學
香粧品學系碩士班
99
Mesoporous bioactive glasses scaffold (MBGs) possess a high specific surface area, and exhibits macropores (about 200−400 μm) and mesopores (2-50 nm) structures. Pore wall functionalized and enhancing bone-regenerative ability are the other advantages of MBGs. For these reasons, MBGs is considered to be a candidate for two main uses, bone tissue engineering and drug controlled delivery system. The purpose of this study is to confirm bioactivity of MBGs by in vitro tests and also as a gentamicin carrier to control drug release. MBGs had been constructed by N2 adsorption/desorption and transmission electron microscope exhibits… a large specific surface area ( 328 m2/g ), pore volume ( 0.71 cm3/g ) and a uniformly distributed pore size ( 7.3 nm ), For comparison, in vitro tests results strongly suggest that MBGs is noncytotoxic, better cell affinity than non-mesoporous bioactive glasses scaffold (BGs) and can help cells division and differentiation. The loading content and drug loading efficiency of MBGs are significant than BGs, and the values are 19.2 mg/g and 31.1%. It also been suggested the release rate of MBGs is much slower than BGs. Loading efficiency and content are depends of of initial concentration. The largest amount of drug adsorption was 39.9 mg/g. The release curve exhibits a two- step release behavior, and fit Higuchi model. It also indicates that gentamicin burst-releases initially for a duration of 24 hrs, and then constantly slows released.
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Chen, Yi-Jhen, and 陳儀蓁. "Synthesis and antibacterial evaluations of silver-incorporated mesoporous bioactive glass." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/96371637959720874960.
Повний текст джерелаАнотація:
碩士高雄醫學大學
香粧品學系碩士班
101
Root canal therapy is an important procedure in endodontic treatment. The current temporary dressing, calcium hydroxide, may fail to eliminate certain facultative bacteria found in the system, which might cause treatment failure. In this study, we synthesis silver-incorporated mesoporous bioactive glass (MBG-Ag). Hoping to combine the biocompatibility and bioactive of bioactive glass and releasable silver ion. Nitrogen Adsorption/Desorption Isotherm, Transmission Electron Microscopy, Scanning Electron Microscopy, X-ray Diffraction and Fourier transform infrared spectroscopy are used to analyze MBG-Ag. The results indicate that incorporating high content of silver will tend to form ball-shape particles, and the mesopore structure (6-7 nm) won’t be affected. The time-dependent and content-dependent antibacterial activity of MBG-Ag is evaluated by using E. coli. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) is 0.75 mg/ml and 1 mg/ml for E. coli, 0.5 mg/ml and 2.5 mg/ml for E. faecalis, respectively. And for the golden standard of temporary dressing, calcium hydroxide, the MIC against E. faecalis is 5 mg/ml. The silver in MBG-Ag is releasable and causing the antibacterial activity after one hour exposure.
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Hong, Bo-Jiang, and 洪柏江. "Surfactant-free synthesis of mesoporous bioactive glass for drug delivery." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/9mj829.
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碩士國立臺灣科技大學
材料科學與工程系
106
The occurrence of the open fractures is often accompanied by complex treatment procedures. In the early stages of treatment for the open fracture, antibiotics are often required to prevent the risk of infection. In addition, in order to achieve an effective therapeutic effect, antibiotics require regular quantitative implantation for the human body. The application of the drug carrier can effectively control the release of the drug and also reduce the number of times to implant the drug into the human body. In the bone fractures of the elderly, the skeletal reparability of the elderly is relatively poor. Bioactive glass is a potential biomaterial for bone implants and drug carriers because it has excellent bioactivity and forms a hydroxyl apatite (HA) layer when immersed in body fluid. In the research of drug carriers, increasing the specific surface area and pore volume can effectively affect the drug loading of the material. One product of these studies is mesoporous bioactive glass (MBG), which has a high specific surface. The common pore-forming agents of MBG are surfactants; however, surfactants present the serious problems of micelle aggregation and carbon contamination. To overcome these problems, hydrogen peroxide (H2O2) has been used as a pore-forming agent to replace the traditional surfactants, such as P123, and F127. In this study, 0, 25, 40, 50, and 69 vol% H2O2-treated MBG powders were synthesized using spray pyrolysis (SP). The corresponding formation mechanisms are also discussed. The results shows that samples with high specific surface area and high pore size have higher drug release.
Частини книг з теми "Mesoporous bioactive glasse"
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Branda, F. "Synthesis and Functionalization of Mesoporous Bioactive Glasses for Drug Delivery." In Clinical Applications of Biomaterials, 257–86. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56059-5_7.
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Verné, Enrica, Francesco Baino, Marta Miola, Giorgia Novajra, Renato Mortera, Barbara Onida, and Chiara Vitale-Brovarone. "Bioactive Glass-Ceramic/Mesoporous Silica Composite Scaffolds for Bone Grafting and Drug Release." In Ceramic Transactions Series, 123–29. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470909812.ch14.
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Lu, P. S., L. C. Chiou, I. L. Chang, C. J. Shih, and L. F. Huang. "The Influences of the Heat-Treated Temperature on Mesoporous Bioactive Gel Glasses Scaffold in the CaO — SiO2 — P2O5 System." In IFMBE Proceedings, 1362–65. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-92841-6_336.
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Gupta, N., and D. Santhiya. "Mesoporous bioactive glass and its applications." In Bioactive Glasses, 63–85. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-08-100936-9.00003-4.
Повний текст джерела
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Bin Zafar Auniq, Reedwan, Namon Hirun, and Upsorn Boonyang. "Three-Dimensionally Ordered Macroporous-Mesoporous Bioactive Glass Ceramics for Drug Delivery Capacity and Evaluation of Drug Release." In Ceramic Materials [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.95290.
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Bioactive glass ceramics (BGCs) have been used in orthopedic and dentistry due to having better osteoconductive and osteostimulative properties. This study aimed to evaluate and compare the drug release properties of two different BGCs; 45S5 and S53P4. The BGCs were composed with four phases of SiO2 – CaO – Na2O – P2O5 system, synthesized by sol–gel method using dual templates; a block-copolymer as mesoporous templates and polymer colloidal crystals as macroporous templates, called three-dimensionally ordered macroporous-mesoporous bioactive glass ceramics (3DOM-MBGCs). In vitro bioactivity test performed by soaking the 3DOM-MBGCs in simulated body fluid (SBF) at 37°C. The results indicated that, the 45S5 have the ability to grow hydroxyapatite-like layer on the surfaces faster than S53P4. Gentamicin drug was used to examine in vitro drug release properties in phosphate buffer solution (PBS). The amount of drug release was quantified through UV/Vis spectroscopy by using o-phthaldialdehyde reagent. S53P4 showed high drug loading content. The outcome of drug release in PBS showed that both S53P4 and 45S5 exhibited a slowly continuous gentamicin release. The resultant drug release profiles were fitted to the Peppas-Korsmeyer model to establish the predominant drug release mechanisms, which revealed that the kinetics of drug release from the glasses mostly dominated by Fickian diffusion mechanism.
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Gómez-Cerezo, N., D. Arcos, and M. Vallet-Regí. "Mesoporous bioactive glasses for biomedical composites." In Materials for Biomedical Engineering, 355–91. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-12-818431-8.00011-8.
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Hum, Jasmin, Anahí Philippart, Elena Boccardi, and Aldo R. Boccaccini. "Mesoporous Bioactive Glass-Based Controlled Release Systems." In Inorganic Controlled Release Technology, 139–59. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-08-099991-3.00005-3.
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Guo, Ya-Ping, Jun-ying Lü, and Qin-Fei Ke. "Mesoporous Bioactive Glasses: Fabrication, Structure, Drug Delivery Property, and Therapeutic Potential." In Biomedical, Therapeutic and Clinical Applications of Bioactive Glasses, 127–51. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-08-102196-5.00004-5.
Повний текст джерела
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Fiume, Elisa, and Francesco Baino. "Robocasting of mesoporous bioactive glasses (MBGs) for bone tissue engineering." In Bioceramics, 327–49. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-08-102999-2.00014-4.
Повний текст джерела
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Wu, Chengtie, Jiang Chang, and Yin Xiao. "Mesoporous Bioactive Glasses for Drug Delivery and Bone Tissue Regeneration." In Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery, 1–24. CRC Press, 2013. http://dx.doi.org/10.1201/b13926-2.
Повний текст джерелаТези доповідей конференцій з теми "Mesoporous bioactive glasse"
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Frent, Corina, Ioana Rusu, and Adriana Vulpoi-Lazar. "Ceria containing mesoporous bioactive glasses with positive biological functionalities." In RAD Conference. RAD Centre, 2022. http://dx.doi.org/10.21175/rad.sum.abstr.book.2022.2.2.
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