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Cabeza, Roberto, and Lars Nyberg. "Imaging Cognition II: An Empirical Review of 275 PET and fMRI Studies." Journal of Cognitive Neuroscience 12, no. 1 (January 2000): 1–47. http://dx.doi.org/10.1162/08989290051137585.
Повний текст джерелаАнотація:
Positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) have been extensively used to explore the functional neuroanatomy of cognitive functions. Here we review 275 PET and fMRI studies of attention (sustained, selective, Stroop, orientation, divided), perception (object, face, space/motion, smell), imagery (object, space/ motion), language (written/spoken word recognition, spoken/ no spoken response), working memory (verbal/numeric, object, spatial, problem solving), semantic memory retrieval (categorization, generation), episodic memory encoding (verbal, object, spatial), episodic memory retrieval (verbal, nonverbal, success, effort, mode, context), priming (perceptual, conceptual), and procedural memory (conditioning, motor, and nonmotor skill learning). To identify consistent activation patterns associated with these cognitive operations, data from 412 contrasts were summarized at the level of cortical Brodmann's areas, insula, thalamus, medial-temporal lobe (including hippocampus), basal ganglia, and cerebellum. For perception and imagery, activation patterns included primary and secondary regions in the dorsal and ventral pathways. For attention and working memory, activations were usually found in prefrontal and parietal regions. For language and semantic memory retrieval, typical regions included left prefrontal and temporal regions. For episodic memory encoding, consistently activated regions included left prefrontal and medial-temporal regions. For episodic memory retrieval, activation patterns included prefrontal, medial-temporal, and posterior midline regions. For priming, deactivations in prefrontal (conceptual) or extrastriate (perceptual) regions were consistently seen. For procedural memory, activations were found in motor as well as in non-motor brain areas. Analysis of regional activations across cognitive domains suggested that several brain regions, including the cerebellum, are engaged by a variety of cognitive challenges. These observations are discussed in relation to functional specialization as well as functional integration.
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Cabeza, Roberto, and Lars Nyberg. "Imaging Cognition: An Empirical Review of PET Studies with Normal Subjects." Journal of Cognitive Neuroscience 9, no. 1 (January 1997): 1–26. http://dx.doi.org/10.1162/jocn.1997.9.1.1.
Повний текст джерелаАнотація:
We review PET studies of higher-order cognitive processes, including attention (sustained and selective), perception (of objects, faces, and locations), language (word listening, reading, and production), working memory (phonological and visuo-spatial), semantic memory retrieval (intentional and incidental), episodic memory retrieval (verbal and nonverbal), priming, and procedural memory (conditioning and skill learning). For each process, we identify activation patterns including the most consistently involved regions. These regions constitute important components of the network of brain regions that underlie each function.
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Bhor, Rohit Jaysing. "AN OVERVIEW ON “MEMORY DYSFUNCTION, TYPES OF MEMORY, AND ITS CLINICAL DISORDERS”." Asian Journal of Pharmaceutical and Clinical Research 9, no. 9 (December 1, 2016): 11. http://dx.doi.org/10.22159/ajpcr.2016.v9s3.14195.
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ABSTRACTAll things considered, memory debilitation is ordinarily seen by doctors in different controls including neurology, psychiatry, pharmaceutical, andsurgery. Memory misfortune is frequently the most crippling element of numerous disarranges, hindering the typical every day exercises of thepatients, and significantly influencing their families. A few recognitions about memory, for example, the ideas of “short term” and “long haul” haveoffered route to a more refined understanding and enhanced order frameworks. These progressions result from neuropsychological investigationsof patients with central mind injuries, neuroanatomical studies in people and creatures, tests in creatures, positron-discharge tomography, usefulattractive reverberation imaging, and possibilities. Memory is presently comprehended to be a gathering of mental capacities that rely on a fewframeworks inside the cerebrum. In this article, we will talk about the accompanying four memory frameworks that are of clinical significance: Wordymemory, semantic memory, procedural memory, and working memory. Memory frameworks can be isolated into those that are definitive and thosethat are non-decisive. Revelatory or express memory will be memory for occasions that can be deliberately reviewed. Non-definitive or verifiablememory, by correlation, is memory that is communicated as an adjustment in conduct and is regularly oblivious.Keywords: Episodic memory, Semantic memory, Working memory, Agnosia, Brain injury, Alzheimer’s disease, Huntington’s disease, Wernicke–Korsakoff’s Syndrome.
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Allen, Richard J. "Classic and recent advances in understanding amnesia." F1000Research 7 (March 16, 2018): 331. http://dx.doi.org/10.12688/f1000research.13737.1.
Повний текст джерелаАнотація:
Neurological amnesia has been and remains the focus of intense study, motivated by the drive to understand typical and atypical memory function and the underlying brain basis that is involved. There is now a consensus that amnesia associated with hippocampal (and, in many cases, broader medial temporal lobe) damage results in deficits in episodic memory, delayed recall, and recollective experience. However, debate continues regarding the patterns of preservation and impairment across a range of abilities, including semantic memory and learning, delayed recognition, working memory, and imagination. This brief review highlights some of the influential and recent advances in these debates and what they may tell us about the amnesic condition and hippocampal function.
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Frith, Emily, Nitin Shivappa, Joshua R. Mann, James R. Hébert, Michael D. Wirth, and Paul D. Loprinzi. "Dietary inflammatory index and memory function: population-based national sample of elderly Americans." British Journal of Nutrition 119, no. 5 (January 24, 2018): 552–58. http://dx.doi.org/10.1017/s0007114517003804.
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AbstractThe objective of this study was to examine the association between dietary inflammatory potential and memory and cognitive functioning among a representative sample of the US older adult population. Cross-sectional data from the 2011–2012 and 2013–2014 National Health and Nutrition Examination Survey were utilised to identify an aggregate sample of adults 60–85 years of age (n 1723). Dietary inflammatory index (DII®) scores were calculated using 24-h dietary recall interviews. Three memory-related assessments were employed, including the Consortium to Establish a Registry for Alzheimer’s disease (CERAD) Word Learning subset, the Animal Fluency test and the Digit Symbol Substitution Test (DSST). Inverse associations were observed between DII scores and the different memory parameters. Episodic memory (CERAD) (badjusted=−0·39; 95 % CI −0·79, 0·00), semantic-based memory (Animal Fluency Test) (badjusted=−1·18; 95 % CI −2·17, −0·20) and executive function and working-memory (DSST) (badjusted=−2·80; 95 % CI −5·58, −0·02) performances were lowest among those with the highest mean DII score. Though inverse relationships were observed between DII scores and memory and cognitive functioning, future work is needed to further explore the neurobiological mechanisms underlying the complex relationship between inflammation-related dietary behaviour and memory and cognition.
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Requena-Komuro, Maï-Carmen, Jessica Jiang, Lucianne Dobson, Elia Benhamou, Lucy Russell, Rebecca L. Bond, Emilie V. Brotherhood, et al. "Remote versus face-to-face neuropsychological testing for dementia research: a comparative study in people with Alzheimer’s disease, frontotemporal dementia and healthy older individuals." BMJ Open 12, no. 11 (November 2022): e064576. http://dx.doi.org/10.1136/bmjopen-2022-064576.
Повний текст джерелаАнотація:
ObjectivesWe explored whether adapting neuropsychological tests for online administration during the COVID-19 pandemic was feasible for dementia research.DesignWe used a longitudinal design for healthy controls, who completed face-to-face assessments 3–4 years before remote assessments. For patients, we used a cross-sectional design, contrasting a prospective remote cohort with a retrospective face-to-face cohort matched for age/education/severity.SettingRemote assessments were conducted using video-conferencing/online testing platforms, with participants using a personal computer/tablet at home. Face-to-face assessments were conducted in testing rooms at our research centre.ParticipantsThe remote cohort comprised 25 patients (n=8 Alzheimer’s disease (AD); n=3 behavioural variant frontotemporal dementia (bvFTD); n=4 semantic dementia (SD); n=5 progressive non-fluent aphasia (PNFA); n=5 logopenic aphasia (LPA)). The face-to-face patient cohort comprised 64 patients (n=25 AD; n=12 bvFTD; n=9 SD; n=12 PNFA; n=6 LPA). Ten controls who previously participated in face-to-face research also took part remotely.Outcome measuresThe outcome measures comprised the strength of evidence under a Bayesian framework for differences in performances between testing environments on general neuropsychological and neurolinguistic measures.ResultsThere was substantial evidence suggesting no difference across environments in both the healthy control and combined patient cohorts (including measures of working memory, single-word comprehension, arithmetic and naming; Bayes Factors (BF)01>3), in the healthy control group alone (including measures of letter/category fluency, semantic knowledge and bisyllabic word repetition; all BF01>3), and in the combined patient cohort alone (including measures of working memory, episodic memory, short-term verbal memory, visual perception, non-word reading, sentence comprehension and bisyllabic/trisyllabic word repetition; all BF01>3). In the control cohort alone, there was substantial evidence in support of a difference across environments for tests of visual perception (BF01=0.0404) and monosyllabic word repetition (BF01=0.0487).ConclusionsOur findings suggest that remote delivery of neuropsychological tests for dementia research is feasible.
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Perez, L. "A Case of a Monolingual Spanish-Speaking Latina with Semantic Variant Primary Progressive Aphasia (svPPA)." Archives of Clinical Neuropsychology 34, no. 7 (August 30, 2019): 1290. http://dx.doi.org/10.1093/arclin/acz029.57.
Повний текст джерелаАнотація:
Abstract Objective Often, individuals with lower educational attainment and limited proficiency in the English language get misdiagnosed and/or undertreated, which can impact their quality of life and other outcomes. The present case study intends to review and discuss the presentation of a monolingual, Spanish-speaking woman with Semantic Variant Primary Progressive Aphasia (svPPA), who was originally referred for a neuropsychological evaluation to determine the severity of her existing Alzheimer’s Disease (AD) diagnosis. Case Description Ms. X, is a 64-year-old, right-handed Hispanic woman with 6 years of education. Symptoms included forgetfulness, restlessness, and insomnia. Her family reported that she was repeating her ideas frequently during conversations and failing to recognize previously acquainted people, including her own relatives. A recent MRI of the brain showed anterior temporal lobe atrophy. Diagnostic Impressions and Outcomes Overall, she showed naming deficits (anomia), impaired verbal fluency, surface dyslexia, and significant problems with comprehension. Executive functioning, sentence repetition, working memory, and attention were generally intact. Qualitatively, her speech was apparently fluent and automatic, yet clearly empty in meaning. In Ms. X’s case, collateral reports of word-finding difficulties, tendency to repeat her thoughts incessantly, associative agnosia and prosopagnosia, and spared repetition and motor speech are strongly indicative of svPPA. Discussion svPPA primarily impacts language production and comprehension, and is characterized by severe anomia, word-finding difficulties, impaired single word comprehension, and in some cases, defective recognition of familiar faces. On testing, impairments can be observed in confrontation naming, with motor speech and repetition, working memory, episodic memory, visuospatial skills, and problem-solving skills relatively intact. Language symptoms are thought to stem from deficits of the semantic system.
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Schnaider Beeri, Michal, Roni Lotan, Jaime Uribarri, Sue Leurgans, David A. Bennett, and Aron S. Buchman. "Higher Dietary Intake of Advanced Glycation End Products Is Associated with Faster Cognitive Decline in Community-Dwelling Older Adults." Nutrients 14, no. 7 (March 31, 2022): 1468. http://dx.doi.org/10.3390/nu14071468.
Повний текст джерелаАнотація:
Objective: Dietary-derived advanced glycation end products (AGEs) vary for different food types and the methods employed during their preparation may contribute to diverse chronic health conditions. The goal of this study was to investigate the associations of dietary AGEs (dAGEs) with cognitive decline in older adults. Methods: Non-demented older adults (n = 684) underwent annual testing with 19 cognitive tests summarized as a global cognitive score based on five cognitive domains. We modified a previously validated food frequency questionnaire designed to assess dAGE. The modified questionnaire assessed portion size and frequency of consumption of six food groups (meat, poultry, fish, cheese, spreads, and processed foods), as well as the method of their preparation (e.g., grilling, boiling). dAGE was the sum of the scores of the six food groups. Linear mixed-effect models were used to examine the association of baseline dAGE with cognitive decline. All models controlled for age, sex, education, race, and body mass index (BMI). Results: Average follow-up was 3.0 years. Higher baseline dAGEs was associated with a faster rate of global cognitive decline (Estimate = −0.003 (standard error = 0.001, p-value = 0.015). This association was driven by declines in episodic memory (−0.004 (0.002, 0.013)) and perceptual speed (−0.003 (0.001, 0.049)) but not by semantic memory, working memory, and visuospatial domains. These associations were not attenuated by controlling for cardiovascular risk factors and diseases, including diabetes. Levels of dAGE of the specific food groups were not associated with cognitive decline. Conclusions: Higher levels of dietary AGE levels in older adults are associated with faster cognitive decline. These data lend further support for the importance of diet and that its modification may slow or prevent late-life cognitive impairment. Further clinical studies will be needed and the molecular mechanisms underlying these associations will need to be identified.
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Stomby, Andreas, Carl-Johan Boraxbekk, Anders Lundquist, Annelie Nordin, Lars-Göran Nilsson, Rolf Adolfsson, Lars Nyberg, and Tommy Olsson. "Higher diurnal salivary cortisol levels are related to smaller prefrontal cortex surface area in elderly men and women." European Journal of Endocrinology 175, no. 2 (August 2016): 117–26. http://dx.doi.org/10.1530/eje-16-0352.
Повний текст джерелаАнотація:
Objective Elevated cortisol levels with aging have been associated with atrophy of the hippocampus and prefrontal cortex (PFC), as well as with impaired cognitive functions in men. However, coexisting diseases have confounded many studies examining these relationships. Studies in women are lacking. Our objective was to test whether salivary cortisol levels were related to morphology of the hippocampus and the PFC, and to cognitive performance. Design A cross-sectional study including 200 elderly (55–80 years old) men and women. Method We used magnetic resonance imaging, tests of episodic-, semantic-, and working memory, visuospatial ability, and cortisol levels in four saliva samples collected during 1 day. Results Area under the curve (AUC) for cortisol levels was negatively related to cortical surface area of the left anterior cingulate gyrus (caudal P<0.001; rostral P=0.006), right lateral orbitofrontal cortex (P=0.004), and right rostral middle frontal gyrus (P=0.003). In women, there was also a negative relationship with cortical surface area in the left rostral middle frontal gyrus (P=0.006). No relationship was found between cortisol levels and hippocampal volume. Conclusion This study suggests that the structure of the medial PFC is related to cortisol levels in both elderly women and men.
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Nyberg, Lars, Petter Marklund, Jonas Persson, Roberto Cabeza, Christian Forkstam, Karl Magnus Petersson, and Martin Ingvar. "Common prefrontal activations during working memory, episodic memory, and semantic memory." Neuropsychologia 41, no. 3 (January 2003): 371–77. http://dx.doi.org/10.1016/s0028-3932(02)00168-9.
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Moustafa, Shatha Rouf, Khalid F. Al-Rawi, Drozdstoi Stoyanov, Arafat Hussein Al-Dujaili, Thitiporn Supasitthumrong, Hussein Kadhem Al-Hakeim та Michael Maes. "The Endogenous Opioid System in Schizophrenia and Treatment Resistant Schizophrenia: Increased Plasma Endomorphin 2, and κ and μ Opioid Receptors Are Associated with Interleukin-6". Diagnostics 10, № 9 (26 серпня 2020): 633. http://dx.doi.org/10.3390/diagnostics10090633.
Повний текст джерелаАнотація:
Background: activation of the immune-inflammatory response system (IRS) and the compensatory immune-regulatory system (CIRS) plays a key role in schizophrenia (SCZ) and treatment resistant SCZ. There are only a few data on immune and endogenous opioid system (EOS) interactions in SCZ and treatment resistant SCZ. Methods: we examined serum β-endorphin, endomorphin-2 (EM2), mu-opioid (MOR) and kappa-opioid (KOR) receptors, and interleukin (IL)-6 and IL-10 in 60 non responders to treatment (NRTT), 55 partial RTT (PRTT) and 43 normal controls. Results: serum EM2, KOR, MOR, IL-6 and IL-10 were significantly increased in SCZ as compared with controls. β-endorphin, EM2, MOR and IL-6 were significantly higher in NRTT than in PRTT. There were significant correlations between IL-6, on the one hand, and β-endorphin, EM2, KOR, and MOR, on the other, while IL-10 was significantly correlated with MOR only. A large part of the variance in negative symptoms, psychosis, hostility, excitation, mannerism, psychomotor retardation and formal thought disorders was explained by the combined effects of EM2 and MOR with or without IL-6 while increased KOR was significantly associated with all symptom dimensions. Increased MOR, KOR, EM2 and IL-6 were also associated with neurocognitive impairments including in episodic, semantic and working memory and executive functions. Conclusion: the EOS contributes to SCZ symptomatology, neurocognitive impairments and a non-response to treatment. In SCZ, EOS peptides/receptors may exert CIRS functions, whereas increased KOR levels may contribute to the pathophysiology of SCZ and EM2 and KOR to a non-response to treatment.
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PRICE, SARAH E., GLYNDA J. KINSELLA, BEN ONG, ELIZABETH MULLALY, MARGARET PHILLIPS, LANKI PANGNADASA-FOX, DIANA PERRE, and ELSDON STOREY. "Learning and memory in amnestic mild cognitive impairment: Contribution of working memory." Journal of the International Neuropsychological Society 16, no. 2 (February 22, 2010): 342–51. http://dx.doi.org/10.1017/s1355617709991391.
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AbstractIn addition to deficits in delayed recall, recent research suggests that participants with amnestic mild cognitive impairment (aMCI) demonstrate diminished use of strategic encoding strategies during learning. Few studies have explored the cognitive mechanisms underlying this deficit. The aim of this study was to investigate in aMCI whether components of working memory (executive attention – attention set-shifting, dividing and focusing attention; and episodic buffer functions – strategic retrieval and manipulation of information) predict strategic encoding strategies during learning (semantic clustering). Thirty-three participants with aMCI and 33 healthy older adults (HOA) were administered neuropsychological tests assessing word-list learning and working memory. The aMCI group demonstrated significant impairment in acquisition, retrieval of information, and decreased use of semantic clustering strategies. Use of semantic clustering in the aMCI group was not predicted by measures of executive attention or phonemic verbal fluency, but was predicted by semantic verbal fluency performance. In the HOA group, semantic clustering was strongly related to semantic verbal fluency. These findings suggest that in aMCI, diminished strategic encoding strategies during learning (semantic clustering) is selectively related to the strategic function of the episodic buffer, but only when in interaction with the manipulation and retrieval of semantic associations. (JINS, 2010, 16, 342–351.)
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Papirovitz, Merav, and Ariela Gigi. "New Contemplation Upon Subjective Memory Complaints as a Self- Report Criterion for MCI Diagnosis." Current Alzheimer Research 18, no. 2 (June 3, 2021): 136–41. http://dx.doi.org/10.2174/1567205018666210416095437.
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Background: Subjective memory complaints are a key component in mild cognitive impairment (MCI) diagnosis. However, studies that examined memory awareness among MCI participants have published contradictory results. One possible explanation for the inconsistent findings could be the disregard from the multidimensional structure of subjective memory. Objectives: The present study is directed at assessing subjective memory among healthy and MCI participants, referring to three main types of memory: episodic, semantic, and working memory. Methods: Participants were 123 adults (aged 50-90). They were divided into two groups, the MCI group, and the control group, according to their objective cognitive performance in RAVL or Mo- CA tests. All participants filled a subjective memory questionnaire, assessing their awareness of episodic, semantic, and working memory. Results: MCI participants estimated their semantic memory as significantly lower in comparison to the estimation of the healthy controls. By contrast, MCI participants showed an overestimation of their episodic memory capabilities compared to the control group. No significant difference was found between groups (MCI and healthy controls) in evaluating their working memory. In addition, for both groups, Pearson’s correlation revealed a significant negative correlation between age and semantic memory evaluation. Such correlation was not found for subjective episodic memory. Discussion: Findings suggest that while people with MCI exhibit poor awareness of their episodic and working memory capabilities, their awareness of their decrease in semantic memory is apparently intact. Therefore, it is suggested that when using the self-report criterion for MCI diagnosis, clinicians should consider the patient’s’ semantic memory complaints.
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Loaiza, Vanessa M., and Sabina Srokova. "Semantic Relatedness Corrects the Age-Related Binding Deficit in Working Memory and Episodic Memory." Journals of Gerontology: Series B 75, no. 9 (May 7, 2019): 1841–49. http://dx.doi.org/10.1093/geronb/gbz055.
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Abstract Objectives It is well known that age differentially impacts aspects of long-term episodic memory (EM): Whereas a binding deficit indicates that older adults are less capable than younger adults to encode or retrieve associations between information (e.g., the pairing between two memoranda, such as lock – race), item memory is relatively intact (e.g., recognizing lock without its original pairing). Method We tested whether this deficit could be corrected by facilitating establishment of the bindings in working memory (WM) through adapting the semantic relatedness of studied pairs according to participants’ ongoing performance (Experiments 1 and 2). We also examined whether this was evident for the long-term retention of pairs that were not tested in WM (Experiment 2). Results The results revealed matched binding and item memory in WM and EM between age groups. Most importantly, older adults required increased semantic strength between word pairs to achieve similar performance to that of younger adults, regardless of whether pairs were immediately tested during the WM task. Discussion These findings indicate that relying on their superior semantic memory can correct the commonly exhibited profound deficit in binding memory in older age.
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D'Angelo, Elisabeth Cochran, Beth A. Ober, and Gregory K. Shenaut. "Combined Memory Training: An Approach for Episodic Memory Deficits in Traumatic Brain Injury." American Journal of Speech-Language Pathology 30, no. 2S (April 16, 2021): 920–32. http://dx.doi.org/10.1044/2020_ajslp-20-00075.
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Purpose The study aimed to test a combination of semantic memory and traditional episodic memory therapies on episodic memory deficits in adults with traumatic brain injury. Method Twenty-five participants who had been diagnosed with traumatic brain injury and had episodic memory deficits were randomly assigned either to a combined memory treatment group ( n = 16) or to a wait-list control group ( n = 9). Before and after treatment, they completed standardized neuropsychological testing for episodic memory and related cognitive domains, including the California Verbal Learning Test–Second Edition, the Controlled Oral Word Association Test, the University of Southern California Repeatable Episodic Memory Test, the Wechsler Abbreviated Scale of Intelligence–Second Edition Matrices, the Test of Everyday Attention, the Memory Assessment Clinics Self-Rating Scale, the Expressive Vocabulary Test–Second Edition, and the Story Recall subtest from the Rivermead Behavioural Memory Test. In addition to a traditional episodic memory therapy, the treatment group received a novel semantic memory–focused therapy, which involved participants finding meaningful connections between diverse concepts represented by sets of two or three words. Results The treatment group demonstrated statistically significant improvement in memory for list learning tasks, and there was a significant difference from pretest to posttest between the treatment group and the wait-list control group. Clinical significance was demonstrated for the treatment group using minimally important difference calculations. Conclusion Combined memory therapy resulted in significant improvements in episodic memory, semantic memory, and attention, in comparison to no treatment. Supplemental Material https://doi.org/10.23641/asha.14049968
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Backeström, Anna, Konstantin Papadopoulos, Sture Eriksson, Tommy Olsson, Micael Andersson, Kaj Blennow, Henrik Zetterberg, Lars Nyberg, and Olov Rolandsson. "Acute hyperglycaemia leads to altered frontal lobe brain activity and reduced working memory in type 2 diabetes." PLOS ONE 16, no. 3 (March 19, 2021): e0247753. http://dx.doi.org/10.1371/journal.pone.0247753.
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How acute hyperglycaemia affects memory functions and functional brain responses in individuals with and without type 2 diabetes is unclear. Our aim was to study the association between acute hyperglycaemia and working, semantic, and episodic memory in participants with type 2 diabetes compared to a sex- and age-matched control group. We also assessed the effect of hyperglycaemia on working memory–related brain activity. A total of 36 participants with type 2 diabetes and 34 controls (mean age, 66 years) underwent hyperglycaemic clamp or placebo clamp in a blinded and randomised order. Working, episodic, and semantic memory were tested. Overall, the control group had higher working memory (mean z-score 33.15 ± 0.45) than the group with type 2 diabetes (mean z-score 31.8 ± 0.44, p = 0.042) considering both the placebo and hyperglycaemic clamps. Acute hyperglycaemia did not influence episodic, semantic, or working memory performance in either group. Twenty-two of the participants (10 cases, 12 controls, mean age 69 years) were randomly invited to undergo the same clamp procedures to challenge working memory, using 1-, 2-, and 3-back, while monitoring brain activity by blood oxygen level–dependent functional magnetic resonance imaging (fMRI). The participants with type 2 diabetes had reduced working memory during the 1- and 2-back tests. fMRI during placebo clamp revealed increased BOLD signal in the left lateral frontal cortex and the anterior cingulate cortex as a function of working memory load in both groups (3>2>1). During hyperglycaemia, controls showed a similar load-dependent fMRI response, whereas the type 2 diabetes group showed decreased BOLD response from 2- to 3-back. These results suggest that impaired glucose metabolism in the brain affects working memory, possibly by reducing activity in important frontal brain areas in persons with type 2 diabetes.
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Wilson, Robert S., Jingyun Yang, Lei Yu, Sue E. Leurgans, Ana W. Capuano, Julie A. Schneider, David A. Bennett, and Patricia A. Boyle. "Postmortem neurodegenerative markers and trajectories of decline in cognitive systems." Neurology 92, no. 8 (January 23, 2019): e831-e840. http://dx.doi.org/10.1212/wnl.0000000000006949.
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ObjectiveTo assess whether neurodegenerative pathologies are differentially related to trajectories of change in different cognitive abilities.MethodsAt annual intervals for up to 21 years, 915 older participants in a longitudinal clinical-pathologic cohort study completed a battery of 15 tests from which previously established composite measures of episodic memory, semantic memory, working memory, and perceptual speed were derived. At death, they underwent a neuropathologic examination to quantify Alzheimer disease pathology, Lewy bodies, transactive response DNA-binding protein 43 (TDP-43) pathology, and hippocampal sclerosis plus multiple markers of cerebrovascular disease. Time-varying effect models were used to assess change over time in the relation of neuropathologic markers to cognitive trajectories.ResultsControlling for pathology, decline in perceptual speed was evident about 15 years before death; modest decline in semantic and working memory occurred later; and there was little change in episodic memory. Each neurodegenerative marker was associated with lower episodic memory function beginning about 10 to 16 years before death. As time before death decreased, Alzheimer disease pathology, Lewy bodies, and hippocampal sclerosis were associated with impairment in other cognitive domains but the association of TDP-43 pathology with cognition continued to be mainly confined to episodic memory.ConclusionsThe results suggest that episodic memory impairment is an early sign of multiple neurodegenerative conditions, which primarily differ in their associations with other cognitive systems.
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Malcorra, Bárbara Luzia Covatti, Natália Bezerra Mota, Janaina Weissheimer, Lucas Porcello Schilling, Maximiliano Agustin Wilson, and Lilian Cristine Hübner. "Low Speech Connectedness in Alzheimer’s Disease is Associated with Poorer Semantic Memory Performance." Journal of Alzheimer's Disease 82, no. 3 (August 3, 2021): 905–12. http://dx.doi.org/10.3233/jad-210134.
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Connected speech is an everyday activity. We aimed to investigate whether connected speech can differentiate oral narrative production between adults with Alzheimer’s disease (AD; n = 24) and cognitively healthy older adults (n = 48). We used graph attributes analysis to represent connected speech. Participants produced oral narratives and performed semantic, episodic, and working memory tasks. AD patients produced less connected narratives than cognitively healthy older adults. Connectedness was associated with semantic memory in AD and with episodic memory in controls. Word-graphs connectedness represents a practical tool to assess cognitive impairment in AD patients.
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Burianova, Hana, and Cheryl L. Grady. "Common and Unique Neural Activations in Autobiographical, Episodic, and Semantic Retrieval." Journal of Cognitive Neuroscience 19, no. 9 (September 2007): 1520–34. http://dx.doi.org/10.1162/jocn.2007.19.9.1520.
Повний текст джерелаАнотація:
This study sought to explore the neural correlates that underlie autobiographical, episodic, and semantic memory. Autobiographical memory was defined as the conscious recollection of personally relevant events, episodic memory as the recall of stimuli presented in the laboratory, and semantic memory as the retrieval of factual information and general knowledge about the world. Our objective was to delineate common neural activations, reflecting a functional overlap, and unique neural activations, reflecting functional dissociation of these memory processes. We conducted an event-related functional magnetic resonance imaging study in which we utilized the same pictorial stimuli but manipulated retrieval demands to extract autobiographical, episodic, or semantic memories. The results show a functional overlap of the three types of memory retrieval in the inferior frontal gyrus, the middle frontal gyrus, the caudate nucleus, the thalamus, and the lingual gyrus. All memory conditions yielded activation of the left medial-temporal lobe; however, we found a functional dissociation within this region. The anterior and superior areas were active in episodic and semantic retrieval, whereas more posterior and inferior areas were active in autobiographical retrieval. Unique activations for each memory type were also delineated, including medial frontal increases for autobiographical, right middle frontal increases for episodic, and right inferior temporal increases for semantic retrieval. These findings suggest a common neural network underlying all declarative memory retrieval, as well as unique neural contributions reflecting the specific properties of retrieved memories.
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Fragueiro, Agustina, Annalisa Tosoni, Matteo Frisoni, Rosalia Di Matteo, Carlo Sestieri, and Giorgia Committeri. "Travel in the Physical and Mental Space: A Behavioral Assessment of the Phylogenetic Continuity Hypothesis Between Egocentric Navigation and Episodic Memory." Evolutionary Psychology 19, no. 3 (July 2021): 147470492110408. http://dx.doi.org/10.1177/14747049211040823.
Повний текст джерелаАнотація:
Based on the neuro-functional association between navigation in the physical and the mental space at the level of the hippocampal-entorhinal system, Buzsáki and Moser (2013) have hypothesized a phylogenetic continuity between spatial navigation and declarative memory functions. According to this proposal, mechanisms of episodic and semantic memory would have evolved from mechanisms of self-based and map-based navigation in the physical space, respectively. Using classic versions of path integration and item recognition tasks in human subjects, we have recently described a correlation and a predictive relationship between abilities in egocentric navigation and episodic memory. Here we aim at confirming and extending this association to the dynamic component of sequential updating in the physical (egocentric navigation) and mental (episodic memory) space, and at investigating the relationship of these self-centered abilities with semantic memory. To this aim, we developed three new experimental tasks in which the dynamic component of updating information is particularly emphasized in the spatial, the temporal, and the semantic domain. The contribution of visual short-term memory to the three tasks was also controlled by including an additional task. The results confirmed the existence of a direct and predictive relationship between self-based spatial navigation and episodic memory. We also found a significant association between egocentric navigation and semantic memory, but this relationship was explained by short-term memory abilities and was mediated by episodic memory functions. Our results support the hypothesis of an evolutionary link between mechanisms that allow spatial navigation in the physical space and time travel in the mental space.
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Gascoigne, Michael B., Mary Lou Smith, Richard Webster, Belinda Barton, Deepak Gill, and Suncica Lah. "Autobiographical Memory in Children with Temporal Lobe Epilepsy." Journal of the International Neuropsychological Society 19, no. 10 (September 19, 2013): 1076–86. http://dx.doi.org/10.1017/s1355617713000970.
Повний текст джерелаАнотація:
AbstractAutobiographical memory involves the recall of personal facts (semantic memory) and re-experiencing of specific personal events (episodic memory). Although impairments in autobiographical memory have been found in adults with unilateral temporal lobe epilepsy (TLE) and attributed to compromised hippocampal integrity, it is not yet known whether this occurs in children with TLE. In the current study, 21 children with TLE and 24 healthy controls of comparable age, sex, and socioeconomic status were administered the Children's Autobiographical Interview. Compared to controls, children with TLE recalled fewer episodic details, but only when no retrieval prompts were provided. There was no difference between the groups for semantic autobiographic details. Interestingly, the number of episodic details recalled increased significantly from 6 to 16 years of age in healthy control children, but not in children with TLE. Exploratory analyses revealed that, within the group of children with TLE, epilepsy factors, including presence or absence of structural hippocampal abnormalities, did not relate to the richness of episodic recall. Our results provide first evidence of autobiographical episodic memory deficits in children with TLE. (JINS, 2013, 19, 1–12)
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Pauls, Franz, Franz Petermann, and Anja Christina Lepach. "Gender differences in episodic memory and visual working memory including the effects of age." Memory 21, no. 7 (October 2013): 857–74. http://dx.doi.org/10.1080/09658211.2013.765892.
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Ilieva, Irena P., Cayce J. Hook, and Martha J. Farah. "Prescription Stimulants' Effects on Healthy Inhibitory Control, Working Memory, and Episodic Memory: A Meta-analysis." Journal of Cognitive Neuroscience 27, no. 6 (June 2015): 1069–89. http://dx.doi.org/10.1162/jocn_a_00776.
Повний текст джерелаАнотація:
The use of prescription stimulants to enhance healthy cognition has significant social, ethical, and public health implications. The large number of enhancement users across various ages and occupations emphasizes the importance of examining these drugs' efficacy in a nonclinical sample. The present meta-analysis was conducted to estimate the magnitude of the effects of methylphenidate and amphetamine on cognitive functions central to academic and occupational functioning, including inhibitory control, working memory, short-term episodic memory, and delayed episodic memory. In addition, we examined the evidence for publication bias. Forty-eight studies (total of 1,409 participants) were included in the analyses. We found evidence for small but significant stimulant enhancement effects on inhibitory control and short-term episodic memory. Small effects on working memory reached significance, based on one of our two analytical approaches. Effects on delayed episodic memory were medium in size. However, because the effects on long-term and working memory were qualified by evidence for publication bias, we conclude that the effect of amphetamine and methylphenidate on the examined facets of healthy cognition is probably modest overall. In some situations, a small advantage may be valuable, although it is also possible that healthy users resort to stimulants to enhance their energy and motivation more than their cognition.
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Moscovitch, Morris. "Memory and Working-with-Memory: A Component Process Model Based on Modules and Central Systems." Journal of Cognitive Neuroscience 4, no. 3 (July 1992): 257–67. http://dx.doi.org/10.1162/jocn.1992.4.3.257.
Повний текст джерелаАнотація:
A neuropsychological model of memory is proposed that incorporates Fodor's (1983) idea of modules and central systems. The model has four essential components: (1) a non-frontal neocortical component that consists of perceptual (and perhaps interpretative semantic) modules that mediate performance on item-specific, implicit tests of memory, (2) a modular medial temporal/hippocampal component that mediates encoding, storage, and retrieval on explicit, episodic tests of memory that are associative/cue dependent, (3) a central system, frontal-lobe component that mediates performance on explicit tests that are strategic and on procedural tests that are rule-bound, and (4) a basal ganglia component that mediates performance on sensorimotor, procedural tests of memory. The usefulness of the modular/central system construct is explored and evidence from studies of normal, amnesic, agnosic, and demented people is provided to support the model.
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DE JAGER, C. A., E. MILWAIN, and M. BUDGE. "Early detection of isolated memory deficits in the elderly: the need for more sensitive neuropsychological tests." Psychological Medicine 32, no. 3 (April 2002): 483–91. http://dx.doi.org/10.1017/s003329170200524x.
Повний текст джерелаАнотація:
Background. Early detection of cognitive decline in the elderly is important because this may precede progression to Alzheimer's disease. The aim of this study was to see whether sensitive neuropsychological tests could identify pre-clinical cognitive deficits and to characterize the cognitive profile of a subgroup with poor memory.Methods. A neuropsychological test battery was administered to a community-dwelling sample of 155 elderly volunteers who were screened with CAMCOG at enrolment (mean age 74·7 years). The battery included tests of episodic memory, semantic and working memory, language and processing speed.Results. Episodic memory test z scores below 1 S.D. from the cohort mean identified 25 subjects with ‘non-robust’ memory performance. This group was compared to the remaining ‘robust memory’ group with a General Linear Model controlling for age, IQ, education and gender. Test performance was significantly different in all tests for episodic and semantic memory, but not in tests for working memory, processing speed and language. CANTAB paired associates learning and spatial recognition tests identified the highest percentages of those in the ‘non-robust memory’ group. Processing speed partialled out the age effect on memory performance for the whole cohort, but the ‘non-robust memory’ group's performance was not associated with age or processing speed.Conclusions. Sensitive neuropsychological tests can detect performance below the norm in elderly people whose performance on MMSE and CAMCOG tests is well within the normal range. Age-related decline in memory performance in a cohort of the elderly may be largely due to inclusion within the cohort of individuals with undetected pre-clinical Alzheimer's disease or isolated memory impairment.
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Ranganath, Charan, and Ken A. Paller. "Frontal Brain Activity during Episodic and Semantic Retrieval: Insights from Event-Related Potentials." Journal of Cognitive Neuroscience 11, no. 6 (November 1999): 598–609. http://dx.doi.org/10.1162/089892999563661.
Повний текст джерелаАнотація:
Previous neuropsychological and neuroimaging results have implicated the prefrontal cortex in memory retrieval, although its precise role is unclear. In the present study, we examined patterns of brain electrical activity during retrieval of episodic and semantic memories. In the episodic retrieval task, participants retrieved autobiographical memories in response to event cues. In the semantic retrieval task, participants generated exemplars in response to category cues. Novel sounds presented intermittently during memory retrieval elicited a series of brain potentials including one identifiable as the P3a potential. Based on prior research linking P3a with novelty detection and with the frontal lobes, we predicted that P3a would be reduced to the extent that novelty detection and memory retrieval interfere with each other. Results during episodic and semantic retrieval tasks were compared to results during a task in which subjects attended to the auditory stimuli. P3a amplitudes were reduced during episodic retrieval, particularly at right lateral frontal scalp locations. A similar but less lateralized pattern of frontal P3a reduction was observed during semantic retrieval. These findings support the notion that the right prefrontal cortex is engaged in the service of memory retrieval, particularly for episodic memories.
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Morris, Robin G., and Michael D. Kopelman. "The Memory Deficits in Alzheimer-Type Dementia: A Review." Quarterly Journal of Experimental Psychology Section A 38, no. 4 (November 1986): 575–602. http://dx.doi.org/10.1080/14640748608401615.
Повний текст джерелаАнотація:
This review is an account of recent experimental studies of memory deficits at the early stages of Alzheimer-type dementia, evaluating these studies in relation to current theories of memory functioning in humans. Whilst memory deficits are found to be widespread, some aspects are more resilient to impairment than others. For example, the processes associated with articulatory rehearsal in working memory are unimpaired despite a reduction in performance on most tests of primary memory. The “implicit” aspects of secondary memory appear to remain unimpaired, in contrast to a marked decline in “explicit” or “episodic” memory. In addition, there is evidence that the rate of forgetting from secondary memory is normal. Some aspects of episodic and semantic memory are found to be impaired as a consequence of a decline in the efficient organisation and processing of verbal material at encoding or retrieval. It is concluded that the deficits share particular features found in organic amnesia, but with additional deficits which relate to impairments in other domains of functioning.
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Wilson, Jack H., Amy H. Criss, Sean A. Spangler, Katherine Walukevich, and Sandra Hewett. "Analysis of acute naproxen administration on memory in young adults: A randomized, double-blind, placebo-controlled study." Journal of Psychopharmacology 31, no. 10 (September 7, 2017): 1374–76. http://dx.doi.org/10.1177/0269881117724406.
Повний текст джерелаАнотація:
Nonsteroidal anti-inflammatory drugs work by non-selectively inhibiting cyclooxygenase enzymes. Evidence indicates that metabolites of the cyclooxygenase pathway play a critical role in the process of learning and memory. We evaluated whether acute naproxen treatment impairs short-term working memory, episodic memory, or semantic memory in a young, healthy adult population. Participants received a single dose of placebo or naproxen (750 mg) in random order separated by 7–10 days. Two hours following administration, participants completed five memory tasks. The administration of acute high-dose naproxen had no effect on memory in healthy young adults.
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Umanath, Sharda, and Jennifer H. Coane. "Face Validity of Remembering and Knowing: Empirical Consensus and Disagreement Between Participants and Researchers." Perspectives on Psychological Science 15, no. 6 (June 12, 2020): 1400–1422. http://dx.doi.org/10.1177/1745691620917672.
Повний текст джерелаАнотація:
Ever since Endel Tulving first distinguished between episodic and semantic memory, the remember/know paradigm has become a standard means of probing the phenomenology of participants’ memorial experiences by memory researchers, neuropsychologists, neuroscientists, and others. However, this paradigm has not been without its problems and has been used to capture many different phenomenological experiences, including retrieval from episodic versus semantic memory, recollection versus familiarity, strength of memory traces, and so on. We first conducted a systematic review of its uses across the literature and then examined how memory experts, other cognitive psychology experts, experts in other areas of psychology, and lay participants (Amazon Mechanical Turk workers) define what it means when one says “I remember” and “I know.” From coding their open-ended responses using a number of theory-bound dimensions, it seems that lay participants do not see eye to eye with memory experts in terms of associating “I remember” responses with recollection and “I know” responses with familiarity. However, there is general consensus with Tulving’s original distinction, linking remembering with memory for events and knowing with semantic memory. Recommendations and implications across fields are discussed.
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Willoughby, Karen A., Mary Pat McAndrews, and Joanne Rovet. "Effects of Early Thyroid Hormone Deficiency on Children's Autobiographical Memory Performance." Journal of the International Neuropsychological Society 19, no. 4 (February 1, 2013): 419–29. http://dx.doi.org/10.1017/s1355617712001488.
Повний текст джерелаАнотація:
AbstractMemory deficits and hippocampal abnormalities have been described in individuals with thyroid hormone (TH) insufficiencies; however, no study has yet examined their autobiographical memory (AM) abilities, which are known to be compromised by hippocampal damage. Investigations in adults have shown that AM consists of both episodic and semantic components and that the hippocampus is preferentially involved in episodic AM. The present study used the Children's Autobiographical Interview (CAI) to study episodic and semantic AM in 79 children aged 9 to 14 years, including 26 with early-treated congenital hypothyroidism (CH), 23 born to women with inadequately treated hypothyroidism during pregnancy (HYPO), and 30 typically developing controls. Results showed that relative to controls, CH and HYPO groups both exhibited weaknesses in episodic AM, but not semantic AM. In particular, CH and HYPO groups showed difficulty in recalling event details (i.e., the main happenings) and visual details from past experiences. Overall, this study highlights the importance of TH for early neurodevelopment and provides critical new insight into the effects of early treated TH deficiency on long-term memory performance. Furthermore, the present study indicates that the CAI is an effective tool for investigating episodic AM impairment in clinical pediatric populations. (JINS, 2013, 19, 1–11)
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Detweiler, Mark, and Walter Schneider. "A Connectionist/Control Architecture for Working Memory and Workload: Why Working Memory is not 7 +/− 2." Proceedings of the Human Factors Society Annual Meeting 31, no. 6 (September 1987): 684–88. http://dx.doi.org/10.1177/154193128703100616.
Повний текст джерелаАнотація:
A runnable simulation architecture for working memory is described that provides an alternative to existing models of working memory, e.g., of Atkinson & Shiffrin (1968) and Baddeley (1986). It is used to interpret a variety of phenomena, including multiple resources, workload, chunking, sequential output, skilled and episodic memories, and stages of skill acquisition. The architecture is based on a set of modules organized into regions which communicate with each other on an innerloop of processing. A new feature of this architecture is a proposed context-storage module that temporarily stores context information in fast changing connection weights. This enables the system to expand effective working memory beyond the traditional 7 +/− 2 items. The context storage system is able to reload modules after short-term information decays or is displaced; in addition, it provides a means of achieving stable, robust processing under conditions of high workload.
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Loprinzi, Paul D., Sierra Day, and Raymond Deming. "Acute Exercise Intensity and Memory Function: Evaluation of the Transient Hypofrontality Hypothesis." Medicina 55, no. 8 (August 7, 2019): 445. http://dx.doi.org/10.3390/medicina55080445.
Повний текст джерелаАнотація:
Background and Objective: The transient hypofrontality hypothesis predicts that memory function will be impaired during high-intensity exercise, as a result of a need for metabolic and cognitive resources to be allocated toward sustaining movement, as opposed to performing a cognitive task. The purpose of these experiments was to evaluate this transient hypofrontality hypothesis. Materials and Methods: Experiment 1 involved participants (n = 24; Mage = 21.9 years) completing four counterbalanced visits. Two visits evaluated working memory function, either at rest or during a high-intensity bout of acute exercise. The other two visits evaluated episodic memory function, either at rest or during a high-intensity bout of acute exercise. Experiment 2 (n = 24; Mage = 20.9 years) extended Experiment 1 by evaluating memory function (working memory) across 4 counterbalanced conditions, including at rest and during light (30% of heart rate reserve; HRR), moderate (50% HRR) and high-intensity (80% HRR) acute exercise. Results: Experiment 1 demonstrated that, when compared to rest, both working memory and episodic memory were impaired during high-intensity acute exercise. Experiment 2 replicated this effect, but then also showed that, unlike high-intensity acute exercise, memory function was not impaired during low- and moderate-intensity acute exercise. Conclusions: Our experiments provide support for the transient hypofrontality hypothesis. Both working memory and episodic memory are impaired during high-intensity acute exercise. Working memory does not appear to be impaired during lower exercise intensities.
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Burke, Deborah M., and D. G. Mackay. "Memory, language, and ageing." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 352, no. 1363 (December 29, 1997): 1845–56. http://dx.doi.org/10.1098/rstb.1997.0170.
Повний текст джерелаАнотація:
This overview provides both theoretical and empirical reasons for emphasizing practice and familiar skills as a practical strategy for enhancing cognitive functioning in old age. Our review of empirical research on age–related changes in memory and language reveals a consistent pattern of spared and impaired abilities in normal old age. Relatively preserved in old age is memory performance involving highly practised skills and familiar information, including factual, semantic and autobiographical information. Relatively impaired in old age is memory performance that requires the formation of new connections, for example, recall of recent autobiographical experiences, new facts or the source of newly acquired facts. This pattern of impaired new learning versus preserved old learning cuts across distinctions between semantic memory, episodic memory, explicit memory and perhaps also implicit memory. However, familiar verbal information is not completely preserved when accessed on the output side rather than the input side: aspects of language production, namely word finding and spelling, exhibit significant age–related declines. This emerging pattern of preserved and impaired abilities presents a fundamental challenge for theories of cognitive ageing, which must explain why some aspects of language and memory are more vulnerable to effects of ageing than others. Information–universal theories, involving mechanisms such as general slowing that are independent of the type or structure of the information being processed, require additional mechanisms to account for this pattern of cognitive aging. Information–specific theories, where the type or structure of the postulated memory units can influence the effects of cognitive ageing, are able to account for this emerging pattern, but in some cases require further development to account for comprehensive cognitive changes such as general slowing.
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Öztekin, Ilke, Clayton E. Curtis, and Brian McElree. "The Medial Temporal Lobe and the Left Inferior Prefrontal Cortex Jointly Support Interference Resolution in Verbal Working Memory." Journal of Cognitive Neuroscience 21, no. 10 (October 2009): 1967–79. http://dx.doi.org/10.1162/jocn.2008.21146.
Повний текст джерелаАнотація:
During working memory retrieval, proactive interference (PI) can be induced by semantic similarity and episodic familiarity. Here, we used fMRI to test hypotheses about the role of the left inferior frontal gyrus (LIFG) and the medial temporal lobe (MTL) regions in successful resolution of PI. Participants studied six-word lists and responded to a recognition probe after a short distracter period. We induced semantic PI by using study lists containing words within the same semantic category (e.g., animals). We also measured PI induced by recent study, which should increase episodic familiarity, by comparing recent negative probes (lures studied in previous trial) to distant negative probes (lures that had not been presented within a block). Resolving both types of PI resulted in enhanced activation in LIFG and MTL regions. We propose that the LIFG and the MTL support successful resolution of interference via controlled retrieval processes that serve to recover detailed episodic (e.g., list-specific or source) information: Specifically, the data suggest that BOLD activation in the LIFG reflects the deployment of controlled retrieval operations, regardless of whether the retrieval attempt succeeds in recovering the target information, whereas MTL activation specifically reflects access to relevant episodic information that serves to successfully resolve PI.
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Allen, David, H. Valerie Curran, and Malcolm Lader. "Effects of lofepramine and dothiepin on memory and psychomotor function in healthy volunteerso." Journal of Psychopharmacology 7, no. 1_suppl (January 1993): 33–38. http://dx.doi.org/10.1177/0269881193007001061.
Повний текст джерелаАнотація:
The effects of single doses of lofepramine (70 mg), dothiepin (50 mg) and placebo on memory and psychomotor function were compared in a cross-over study with 12 healthy volunteers. Dothiepin produced a differential pattern of effects across the range of memory assessments used, impairing episodic memory and slowing learning in a procedural task but not affecting working, semantic or implicit memory. Dothiepin also impaired performance on two attentional tasks, slowed down reaction times and increased subjective sedation. Lofepramine was similar to placebo on nearly all objective measures, but produced effects similar to dothiepin on critical flicker fusion threshold, salivary flow and most EEG wavebands. It is concluded that, unlike lofepramine, acute dosage with dothiepin is associated with sedative effects and impairments of concentration and memory.
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Ellmore, Timothy M., Bridget Mackin, and Kenneth Ng. "Saccades and handedness interact to affect scene memory." PeerJ 6 (November 15, 2018): e5969. http://dx.doi.org/10.7717/peerj.5969.
Повний текст джерелаАнотація:
Repetitive saccades benefit memory when executed before retrieval, with greatest effects for episodic memory in consistent-handers. Questions remain including how saccades affect scene memory, an important visual component of episodic memory. The present study tested how repetitive saccades affect working and recognition memory for novel scenes. Handedness direction (left–right) and degree (strong/consistent vs. mixed/inconsistent) was measured by raw and absolute laterality quotients respectively from an 8-question handedness inventory completed by 111 adults. Each then performed either 30 s of repetitive horizontal saccades or fixation before or after tasks of scene working memory and scene recognition. Regression with criterion variables of overall percent correct accuracy and d-prime sensitivity showed that when saccades were made before working memory, there was better overall accuracy as a function of increased direction but not degree of handedness. Subjects who made saccades before working memory also performed worse during subsequent recognition memory, while subjects who fixated or made saccades after the working memory task performed better. Saccades made before recognition resulted in recognition accuracy that was better (Cohen’s d = 0.3729), but not significantly different from fixation before recognition. The results demonstrate saccades and handedness interact to affect scene memory with larger effects on encoding than recognition. Saccades before scene encoding in working memory are detrimental to short- and long-term memory, especially for those who are not consistently right-handed, while saccade execution before scene recognition does not appear to benefit recognition accuracy. The findings are discussed with respect to theories of interhemispheric interaction and control of visuospatial attention.
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XIE, SHARON X., DAVID J. LIBON, XINGMEI WANG, LAUREN MASSIMO, PEACHIE MOORE, LUISA VESELY, ALEA KHAN, et al. "Longitudinal patterns of semantic and episodic memory in frontotemporal lobar degeneration and Alzheimer’s disease." Journal of the International Neuropsychological Society 16, no. 2 (December 11, 2009): 278–86. http://dx.doi.org/10.1017/s1355617709991317.
Повний текст джерелаАнотація:
AbstractThe longitudinal assessment of episodic and semantic memory was obtained from 236 patients diagnosed with Alzheimer’s disease (AD, n = 128) and with frontotemporal lobar degeneration (FTLD, n = 108), including patients with a social comportment/dysexecutive (SOC/EXEC) disorder, progressive nonfluent aphasia (PNFA), semantic dementia (SemD), and corticobasal syndrome (CBS). At the initial assessment, AD patients obtained a lower score on the delayed free recall test than other patients. Longitudinal analyses for delayed free recall found converging performance, with all patients reaching the same level of impairment as AD patients. On the initial evaluation for delayed recognition, AD patients also obtained lower scores than other groups. Longitudinal analyses for delayed recognition test performance found that AD patients consistently produced lower scores than other groups and no convergence between AD and other dementia groups was seen. For semantic memory, there were no initial between-group differences. However, longitudinal analyses for semantic memory revealed group differences over illness duration, with worse performance for SemD versus AD, PNFA, SOC/EXEC, and CBS patients. These data suggest the presence of specific longitudinal patterns of impairment for episodic and semantic memory in AD and FTLD patients suggesting that all forms of dementia do not necessarily converge into a single phenotype. (JINS, 2010, 16, 278–286.)
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Gardiner, John M. "Episodic memory and autonoetic consciousness: a first–person approach." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 356, no. 1413 (September 29, 2001): 1351–61. http://dx.doi.org/10.1098/rstb.2001.0955.
Повний текст джерелаАнотація:
Episodic memory is identified with autonoetic consciousness, which gives rise to remembering in the sense of self–recollection in the mental re–enactment of previous events at which one was present. Autonoetic consciousness is distinguished from noetic consciousness, which gives rise to awareness of the past that is limited to feelings of familiarity or knowing. Noetic consciousness is identified not with episodic but with semantic memory, which involves general knowledge. A recently developed approach to episodic memory makes use of ‘first–person’ reports of remembering and knowing. Studies using this approach have revealed many independent variables that selectively affect remembering and others that selectively affect knowing. These studies can also be interpreted in terms of distinctiveness and fluency of processing. Remembering and knowing do not correspond with degrees of confidence in memory. Nor does remembering always control the memory response. There is evidence that remembering is selectively impaired in various populations, including not only amnesic patients and older adults but also adults with Asperger's syndrome. This first–person approach to episodic memory represents one way in which that most elusive aspect of consciousness, its subjectivity, can be investigated scientifically. The two kinds of conscious experiences can be manipulated experimentally in ways that are systematic, replicable and intelligible theoretically.
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Ueber, Ralph, Tobias Stegmann, Zâine Brockmeyer, Matthias Berger, and Hans M. Olbrich. "Selective Memory Impairment in Schizophrenia: A Comparison with that Observed in Alcoholism." Zeitschrift für Neuropsychologie 12, no. 1 (February 2001): 15–20. http://dx.doi.org/10.1024//1016-264x.12.1.15.
Повний текст джерелаАнотація:
Abstract: This study assessed the pattern of memory performance both in working memory components and episodic long-term memory in a sample of 30 schizophrenic patients, showing intact intellectual and attentional functions. The patients were compared with 30 alcoholics and 30 normal control subjects, matched for age, sex and estimated premorbid IQ. Intellectual functions, assessed using a short form of WAIS, showed no deficits in estimated Full-Scale IQ between the three groups. Attention, working memory, verbal and visual long-term memory were assessed by the subtests of WMS-R. Schizophrenic patients only showed poor overall performance in verbal and visual long-term memory, whereas alcoholics showed a broader pattern of cognitive dysfunction including attentional, working memory and verbal long-term memory components. Taken together the neuropsychological pattern of intact working memory components and impaired long-term memory in schizophrenia is similar to the classic amnesic syndrome and suggest a selective medial temporal-hippocampal dysfunction.
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Burgess, Neil, Suzanna Becker, John A. King, and John O'Keefe. "Memory for events and their spatial context: models and experiments." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 356, no. 1413 (September 29, 2001): 1493–503. http://dx.doi.org/10.1098/rstb.2001.0948.
Повний текст джерелаАнотація:
The computational role of the hippocampus in memory has been characterized as: (i) an index to disparate neocortical storage sites; (ii) a time–limited store supporting neocortical long–term memory; and (iii) a content–addressable associative memory. These ideas are reviewed and related to several general aspects of episodic memory, including the differences between episodic, recognition and semantic memory, and whether hippocampal lesions differentially affect recent or remote memories. Some outstanding questions remain, such as: what characterizes episodic retrieval as opposed to other forms of read–out from memory; what triggers the storage of an event memory; and what are the neural mechanisms involved? To address these questions a neural–level model of the medial temporal and parietal roles in retrieval of the spatial context of an event is presented. This model combines the idea that retrieval of the rich context of real–life events is a central characteristic of episodic memory, and the idea that medial temporal allocentric representations are used in long–term storage while parietal egocentric representations are used to imagine, manipulate and re–experience the products of retrieval. The model is consistent with the known neural representation of spatial information in the brain, and provides an explanation for the involvement of Papez's circuit in both the representation of heading direction and in the recollection of episodic information. Two experiments relating to the model are briefly described. A functional neuroimaging study of memory for the spatial context of life–like events in virtual reality provides support for the model's functional localization. A neuropsychological experiment suggests that the hippocampus does store an allocentric representation of spatial locations.
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Vandekerckhove, Marie M. P., Hans J. Markowitsch, Markus Mertens, and Friedrich G. Woermann. "Bi-Hemispheric Engagement in the Retrieval of Autobiographical Episodes." Behavioural Neurology 16, no. 4 (2005): 203–10. http://dx.doi.org/10.1155/2005/460745.
Повний текст джерелаАнотація:
Functional magnetic resonance imaging (fMRI) was used to study the neural correlates of neutral, stressful, negative and positive autobiographical memories. The brain activity produced by these different kinds of episodic memory did not differ significantly, but a common pattern of activation for different kinds of autobiographical memory was revealed that included (1) largely bilateral portions of the medial and superior temporal lobes, hippocampus and parahippocampus, (2) portions of the ventral, medial, superior and dorsolateral prefrontal cortex, (3) the anterior and posterior cingulate, including the retrosplenial, cortex, (4) the parietal cortex, and (5) portions of the cerebellum. The brain regions that were mainly activated constituted an interactive network of temporal and prefrontal areas associated with structures of the extended limbic system. The main bilateral activations with left-sided preponderance probably reflected reactivation of complex semantic and episodic self-related information representations that included previously experienced contexts. In conclusion, the earlier view of a strict left versus right prefrontal laterality in the retrieval of semantic as opposed to episodic autobiographical memory, may have to be modified by considering contextual variables such as task demands and subject variables. Consequently, autobiographical memory integration should be viewed as based on distributed bi-hemispheric neural networks supporting multi-modal, emotionally coloured components of personal episodes.
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Ganmore, Ithamar, Isak Elkayam, Ramit Ravona-Springer, Hung-Mo Lin, Xiaoyu Liu, Meir Plotnik, Aron S. Buchman, et al. "DETERIORATION IN MOTOR FUNCTION OVER TIME IN OLDER ADULTS WITH TYPE 2 DIABETES IS ASSOCIATED WITH ACCELERATED COGNITIVE DECLINE." Endocrine Practice 26, no. 10 (October 2020): 1143–52. http://dx.doi.org/10.4158/ep-2020-0289.
Повний текст джерелаАнотація:
Objective: Type 2 diabetes (T2D) is associated with motor impairments and a higher dementia risk. The relationships of motor decline with cognitive decline in T2D older adults has rarely been studied. Using data from the Israel Diabetes and Cognitive Decline study (N = 892), we examined associations of decline in motor function with cognitive decline over a 54-month period. Methods: Motor function measures were strength (handgrip) and gait speed (time to walk 3 m). Participants completed a neuropsychologic battery of 13 tests transformed into z-scores, summarized into 4 cognitive domains: episodic memory, attention/working memory, executive functions, and language/semantic categorization. The average of the 4 domains’ z-scores defined global cognition. Motor and cognitive functions were assessed in 18-months intervals. A random coefficients model delineated longitudinal relationships of cognitive decline with baseline and change from baseline in motor function, adjusting for sociodemographic, cardiovascular, and T2D-related covariates. Results: Slower baseline gait speed levels were significantly associated with more rapid decline in global cognition ( P = .004), language/semantic categorization ( P = .006) and episodic memory ( P = .029). Greater decline over time in gait speed was associated with an accelerated rate of decline in global cognition ( P = .050), attention/working memory ( P = .047) and language/semantic categorization ( P<.001). Baseline strength levels were not associated with cognitive decline but the rate of declining strength was associated with an accelerated decline in executive functions ( P = .025) and language/semantic categorization ( P = .006). Conclusion: In T2D older adults, the rate of decline in motor function, beyond baseline levels, was associated with accelerated cognitive decline, suggesting that cognitive and motor decline share common neuropathologic mechanisms in T2D. Abbreviations: HbA1c = hemoglobin A1c; IDCD = Israel Diabetes and Cognitive Decline; T2D = type 2 diabetes
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LORENTE-ROVIRA, E., E. POMAROL-CLOTET, R. A. McCARTHY, G. E. BERRIOS, and P. J. McKENNA. "Confabulation in schizophrenia and its relationship to clinical and neuropsychological features of the disorder." Psychological Medicine 37, no. 10 (May 17, 2007): 1403–12. http://dx.doi.org/10.1017/s0033291707000566.
Повний текст джерелаАнотація:
ABSTRACTBackgroundA form of confabulation has been documented in schizophrenia and appears to be related to the symptom of thought disorder. It is unclear whether it is associated with the same pattern of neuropsychological deficits as confabulation in neurological patients.MethodThirty-four patients with chronic schizophrenia, including those with and without thought disorder, and 17 healthy controls were given a fable recall task to elicit confabulation. They were also examined on a range of executive, episodic and semantic memory tests.ResultsConfabulation was seen at a significantly higher rate in the schizophrenic patients than the controls, and predominated in those with thought disorder. Neuropsychologically, it was not a function of general intellectual impairment, and was not clearly related to episodic memory or executive impairment. However, there were indications of an association with semantic memory impairment.ConclusionsThe findings support the existence of a form of confabulation in schizophrenia that is related to thought disorder and has a different neuropsychological signature to the neurological form of the symptom.
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Pahlen, Shandell, Michael Stallings, Robin Corley, Sally Wadsworth, and Chandra Reynolds. "Consequential Impacts of Tobacco Use on Cognitive Performance." Innovation in Aging 5, Supplement_1 (December 1, 2021): 997. http://dx.doi.org/10.1093/geroni/igab046.3580.
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Abstract Tobacco use represents a pernicious lifestyle factor that may influence processes of aging, including cognitive functioning. As individuals tend to start smoking before adulthood, it may serve as an important factor in cognitive development and maintenance. We explored smoking history-cognition associations in a sample approaching midlife. Study data was derived from the Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife 1; N = 1195 [53% F]; x̄age = 33.2 years, SD = 5.0). All cognitive measures were t-scored covering working memory, spatial reasoning, processing speed (WAIS-III Digit Span, Block Design, and Digit Symbol, and Colorado Perceptual Speed) and episodic memory domains (Picture Memory, immediate and delayed). Tobacco use measures included ever-smokers, current-smokers, and log-transformed packyears. Mixed-effects regression models were applied, accounting for sex, age, race, ethnicity, and clustering among siblings. Tobacco use was associated with worse episodic memory, spatial and speed performance, but not working memory. When educational attainment was included, patterns remained consistent though attenuated. Results suggested current-smokers scored 0.27 to 0.36 SD lower than non-smokers on speed and spatial reasoning tasks. Episodic memory performance was reduced by approximately 0.07 to 0.1 SD per log packyear. In a sample approaching midlife, the harmful impacts of tobacco use on cognitive performance may be already apparent with cumulative impacts of packyears on episodic memory and current smoking associated with spatial and speed performance. This work helps to elucidate the temporal associations of an important lifestyle factor that may influence cognitive functioning prior to midlife.
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Balthazar, Marcio L. F., José E. Martinelli, Fernando Cendes, and Benito P. Damasceno. "Lexical semantic memory in amnestic mild cognitive impairment and mild Alzheimer's disease." Arquivos de Neuro-Psiquiatria 65, no. 3a (September 2007): 619–22. http://dx.doi.org/10.1590/s0004-282x2007000400014.
Повний текст джерелаАнотація:
OBJECTIVE: To study lexical semantic memory in patients with amnestic mild cognitive impairment (aMCI), mild Alzheimer's disease (AD) and normal controls. METHOD: Fifteen mild AD, 15 aMCI, and 15 normal control subjects were included. Diagnosis of AD was based on DSM-IV and NINCDS-ADRDA criteria, and that of aMCI, on the criteria of the International Working Group on Mild Cognitive Impairment, using CDR 0.5 for aMCI and CDR 1 for mild AD. All subjects underwent semantic memory tests (Boston Naming-BNT, CAMCOG Similarities item), Rey Auditory Verbal Learning Test (RAVLT), Mini-Mental Status Examination (MMSE), neuropsychological tests (counterproofs), and Cornell Scale for Depression in Dementia. Data analysis used Mann-Whitney test for intergroup comparisons and Pearson's coefficient for correlations between memory tests and counterproofs (statistical significance level was p<0.05). RESULTS: aMCI patients were similar to controls on BNT and Similarities, but worse on MMSE and RAVLT. Mild AD patients scored significantly worse than aMCI and controls on all tests. CONCLUSION: aMCI impairs episodic memory but tends to spare lexical semantic system, which can be affected in the early phase of AD.
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Orsolini, Margherita, Francesca Federico, Michele Vecchione, Giorgia Pinna, Micaela Capobianco, and Sergio Melogno. "How Is Working Memory Related to Reading Comprehension in Italian Monolingual and Bilingual Children?" Brain Sciences 13, no. 1 (December 28, 2022): 58. http://dx.doi.org/10.3390/brainsci13010058.
Повний текст джерелаАнотація:
This study explored how working memory resources contributed to reading comprehension using tasks that focused on maintenance of verbal information in the phonological store, the interaction between the central executive and the phonological store (WMI), and the storage of bound semantic content in the episodic buffer (immediate narrative memory). We analysed how performance in these tasks was related to text decoding (reading speed and accuracy), listening and reading comprehension. The participants were 62 monolingual and 36 bilingual children (mean age nine years, SD = 9 months) enrolled in the same Italian primary school. Bilingual children were born to immigrant parents and had a long history of exposure to Italian as a second language. The regression analyses showed that reading accuracy and listening comprehension were associated with reading comprehension for monolingual and bilingual children. Two working memory components—WMI and immediate narrative memory—exhibited indirect effects on reading comprehension through reading accuracy and listening comprehension, respectively. Such effects occurred only for monolingual children. We discuss the implications of such findings for text reading and comprehension in monolinguals and bilinguals.
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Komanduri, Mrudhula, Karen Savage, Ana Lea, Grace McPhee, Karen Nolidin, Saurenne Deleuil, Con Stough, and Shakuntla Gondalia. "The Relationship between Gut Microbiome and Cognition in Older Australians." Nutrients 14, no. 1 (December 24, 2021): 64. http://dx.doi.org/10.3390/nu14010064.
Повний текст джерелаАнотація:
Ageing is associated with changes in biological processes, including reductions in cognitive functions and gut microbiome diversity. However, not much is known about the relationship between cognition and the microbiome with increasing age. Therefore, we examined the relationship between the gut microbiome and cognition in 69 healthy participants aged 60–75 years. The gut microbiome was analysed with the 16S rRNA sequencing method. The cognitive assessment included the Cognitive Drug Research computerised assessment battery, which produced five cognitive factors corresponding to ‘Quality of Episodic Secondary Memory’, ‘Quality of Working Memory’, ‘Continuity of Attention, ‘Speed of Memory’ and ‘Power of Concentration’. Multiple linear regression showed that the bacterial family Carnobacteriaceae explained 9% of the variance in predicting Quality of Episodic Secondary Memory. Alcaligenaceae and Clostridiaceae explained 15% of the variance in predicting Quality of Working Memory; Bacteroidaceae, Barnesiellaceae, Rikenellaceae and Gemellaceae explained 11% of the variance in Power of Concentration. The present study provides specific evidence of a relationship between specific families of bacteria and different domains of cognition.
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Pergola, Giulio, Christian Bellebaum, Britta Gehlhaar, Benno Koch, Michael Schwarz, Irene Daum, and Boris Suchan. "The Involvement of the Thalamus in Semantic Retrieval: A Clinical Group Study." Journal of Cognitive Neuroscience 25, no. 6 (June 2013): 872–86. http://dx.doi.org/10.1162/jocn_a_00364.
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There is increasing attention about the role of the thalamus in high cognitive functions, including memory. Although the bulk of the evidence refers to episodic memory, it was recently proposed that the mediodorsal (MD) and the centromedian–parafascicular (CM–Pf) nuclei of the thalamus may process general operations supporting memory performance, not only episodic memory. This perspective agrees with other recent fMRI findings on semantic retrieval in healthy participants. It can therefore be hypothesized that lesions to the MD and the CM–Pf impair semantic retrieval. In this study, 10 patients with focal ischemic lesions in the medial thalamus and 10 healthy controls matched for age, education, and verbal IQ performed a verbal semantic retrieval task. Patients were assigned to a target clinical group and a control clinical group based on lesion localization. Patients did not suffer from aphasia and performed in the range of controls in a categorization and a semantic association task. However, target patients performed poorer than healthy controls on semantic retrieval. The deficit was not because of higher distractibility but of an increased rate of false recall and, in some patients, of a considerably increased rate of misses. The latter deficit yielded a striking difference between the target and the control clinical groups and is consistent with anomia. Follow-up high-resolution structural scanning session in a subsample of patients revealed that lesions in the CM–Pf and MD were primarily associated with semantic retrieval deficits. We conclude that integrity of the MD and the CM–Pf is required for semantic retrieval, possibly because of their role in the activation of phonological representations.
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Bloomfield, Michael A. P., Sebastian F. Green, Chandni Hindocha, Yumeya Yamamori, Jocelyn Lok Ling Yim, Augustus P. M. Jones, Hannah R. Walker, et al. "The effects of acute cannabidiol on cerebral blood flow and its relationship to memory: An arterial spin labelling magnetic resonance imaging study." Journal of Psychopharmacology 34, no. 9 (August 7, 2020): 981–89. http://dx.doi.org/10.1177/0269881120936419.
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Background: Cannabidiol (CBD) is being investigated as a potential treatment for several medical indications, many of which are characterised by altered memory processing. However, the mechanisms underlying these effects are unclear. Aims: Our primary aim was to investigate how CBD influences cerebral blood flow (CBF) in regions involved in memory processing. Our secondary aim was to determine if the effects of CBD on CBF were associated with differences in working and episodic memory task performance. Methods: We used a randomised, crossover, double-blind design in which 15 healthy participants were administered 600 mg oral CBD or placebo on separate days. We measured regional CBF at rest using arterial spin labelling 3 h after drug ingestion. We assessed working memory with the digit span (forward, backward) and n-back (0-back, 1-back, 2-back) tasks, and we used a prose recall task (immediate and delayed) to assess episodic memory. Results: CBD increased CBF in the hippocampus (mean (95% confidence intervals) = 15.00 (5.78–24.21) mL/100 g/min, t14 = 3.489, Cohen’s d = 0.75, p = 0.004). There were no differences in memory task performance, but there was a significant correlation whereby greater CBD-induced increases in orbitofrontal CBF were associated with reduced reaction time on the 2-back working memory task ( r= −0.73, p = 0.005). Conclusions: These findings suggest that CBD increases CBF to key regions involved in memory processing, particularly the hippocampus. These results identify potential mechanisms of CBD for a range of conditions associated with altered memory processing, including Alzheimer’s disease, schizophrenia, post-traumatic stress disorder and cannabis-use disorders.
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Walters, Elizabeth R., and Valerie E. Lesk. "The Effect of Prior Caffeine Consumption on Neuropsychological Test Performance: A Placebo-Controlled Study." Dementia and Geriatric Cognitive Disorders 41, no. 3-4 (2016): 146–51. http://dx.doi.org/10.1159/000443952.
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Background: The aim of this study was to investigate whether the prior consumption of 200 mg of pure caffeine affected neuropsychological test scores in a group of elderly participants aged over 60 years. Method: Using a double-blind placebo versus caffeine design, participants were randomly assigned to receive 200 mg of caffeine or placebo. A neuropsychological assessment testing the domains of general cognitive function, processing speed, semantic memory, episodic memory, executive function, working memory and short-term memory was carried out. Results: Significant interaction effects between age, caffeine and scores of executive function and processing speed were found; participants who had received caffeine showed a decline in performance with increasing age. This effect was not seen for participants who received placebo. Conclusion: The results highlight the need to consider and control prior caffeine consumption when scoring neuropsychological assessments in the elderly, which is important for accuracy of diagnosis and corresponding normative data.