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Добірка наукової літератури з теми "Melanoma, Cancer, Tomato, Polyphenols"

Автор: Grafiati

Опубліковано: 14 березня 2023

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Статті в журналах з теми "Melanoma, Cancer, Tomato, Polyphenols"

Pop, Teodora Daria, and Zorita Diaconeasa. "Recent Advances in Phenolic Metabolites and Skin Cancer." International Journal of Molecular Sciences 22, no. 18 (September 8, 2021): 9707. http://dx.doi.org/10.3390/ijms22189707.

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Skin cancer represents any tumor development from the cutaneous structures within the epidermis, dermis or subcutaneous tissue, and is considered to be the most prevalent type of cancer. Compared to other types of cancer, skin cancer is proven to have a positive growth rate of prevalence and mortality. There are available various treatments, including chemotherapy, immunotherapy, radiotherapy and targeted therapy, but because of the multidrug resistance development, a low success has been registered. By this, the importance of studying naturally occurring compounds that are both safe and effective in the chemoprevention of skin cancer is emphasized. This review focuses on melanoma because it is the deadliest form of skin cancer, with a significantly increasing incidence in the last decades. As chemopreventive agents, we present polyphenols and their antioxidant activity, anti-inflammatory effect, their ability to balance the cell cycle and to induce apoptosis and their various other effects on skin melanoma. Besides chemoprevention, studies suggest that polyphenols can have treating abilities in some conditions. The limitations of using polyphenols are also pointed out, which are related to their poor bioavailability and stability, but as the technology is well developed, it is possible to augment the efficacy of polyphenols in the case of melanoma.

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Isacescu, Ecaterina, Paul Chiroi, Oana Zanoaga, Andreea Nutu, Liviuta Budisan, Radu Pirlog, Atanas G. Atanasov, and Ioana Berindan-Neagoe. "Melanoma Cellular Signaling Transduction Pathways Targeted by Polyphenols Action Mechanisms." Antioxidants 12, no. 2 (February 7, 2023): 407. http://dx.doi.org/10.3390/antiox12020407.

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Melanoma is the most aggressive type of skin cancer. Although different anti-melanoma treatments are available, their efficacy is still improvable, and the number of deaths continues to increase worldwide. A promising source of antitumor agents could be presented by polyphenols—natural plant-based compounds. Over the past decades, many studies have described multiple anticancer effects of polyphenols in melanoma, presenting their potential interactions with targeted molecules from different signaling pathways. However, to our knowledge, there is no comprehensive review on polyphenols-regulated mechanisms in melanoma cells available in the literature. To fulfill this gap, this article aims to summarize the current knowledge of molecular mechanisms of action regulated by polyphenols involved in melanoma initiation and progression. Here, we focus on in vitro and in vivo effects of polyphenol treatments on tumor-essential cellular pathways, such as cell proliferation, apoptosis, autophagy, inflammation, angiogenesis, and metastasis. Moreover, emerging studies regarding the well-marked role of polyphenols in the regulation of microRNAs (miRNAs), highlighting their contribution to melanoma development, are also epitomized. Finally, we hope this review will provide a firm basis for developing polyphenol-based therapeutic agents in melanoma treatment.

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Martí, Raúl, Salvador Roselló, and Jaime Cebolla-Cornejo. "Tomato as a Source of Carotenoids and Polyphenols Targeted to Cancer Prevention." Cancers 8, no. 6 (June 20, 2016): 58. http://dx.doi.org/10.3390/cancers8060058.

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Chen, Xianjin, Lili Chang, Yan Qu, Jinning Liang, Waishu Jin, and Xiujuan Xia. "Tea polyphenols inhibit the proliferation, migration, and invasion of melanoma cells through the down-regulation of TLR4." International Journal of Immunopathology and Pharmacology 31 (January 1, 2018): 039463201773953. http://dx.doi.org/10.1177/0394632017739531.

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Анотація:

Melanoma is the most common skin cancer and malignant melanoma which can cause skin cancer-related deaths. Toll-like receptor 4 (TLR4) had been reported to play an important role in melanoma, and tea polyphenol (TP) is regarded as an anticancer substance. However, the relationship between TP and TLR4 in melanoma is not well explored. Therefore, our aim is to figure out how TP has an influence on melanoma. Melanoma cell lines (B16F10 and A375) were treated with TP and lipopolysaccharides (LPS). Western blot assay was used to examine TLR4 expression, and MTT assay was conducted to assess proliferation. Wound healing assay was conducted to evaluate the migration of melanoma cells, and transwell assay was used to examine the melanoma cells’ invasiveness. Besides, in vivo experiments were practiced for TP function in mice with melanoma cells. TP inhibited the proliferation, migration and invasion ability of melanoma cells, which displayed a dosage and time dependence. TLR4 was highly expressed in melanoma cells compared with normal skin cells. TP could suppress TLR4 expression both in normal melanomas and in stimulated melanomas by TLR4 agonist LPS. Suppressing TLR4 in melanomas could inhibit cell function (proliferation, migration, and invasion), and blocking the expression of 67LR could abolish TP function on TLR4. TP can inhibit melanoma (B16F10) growth in vivo.

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Helyes, Lajos, Zoltán Pék, Sára Brandt, and Andrea Lugasi. "Analysis of Antioxidant Compounds and Hydroxymethylfurfural in Processing Tomato Cultivars." HortTechnology 16, no. 4 (January 2006): 615–19. http://dx.doi.org/10.21273/horttech.16.4.0615.

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Tomato (Lycopersicon esculentum) fruit is an important source of antioxidants, which are important in the prevention of many cancer types and cardiovascular diseases. In ripe tomato fruit, one of the most significant antioxidant compounds is lycopene. In this study, effects of the cultivars and the environmental conditions on the lycopene content were investigated. Temperature effect was characterized by calculating growing degree-day (GDD). Relationships among lycopene, total polyphenols, organic acid, and total antioxidant status (TAS) were analyzed. A variation of more than 30% was found among the lycopene levels of five processing tomato cultivars. Lycopene content ranged from 79.7 to 155.0 mg·kg–1 fresh weight. There was a significant difference between the lycopene concentrations of fruit harvested at two different dates. The values were higher at the second harvest, probably due to the cooler weather conditions preceding that harvest. Total polyphenols correlated strongly with TAS but the other antioxidants did not have any relationship to TAS. GDD were strongly and positively correlated with hydroxymethylfurfural content in fresh tomatoes.

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Prakash, Monica D., Lily Stojanovska, Jack Feehan, Kulmira Nurgali, Elizabeth L. Donald, Magdalena Plebanski, Matthew Flavel, Barry Kitchen, and Vasso Apostolopoulos. "Anti-cancer effects of polyphenol-rich sugarcane extract." PLOS ONE 16, no. 3 (March 10, 2021): e0247492. http://dx.doi.org/10.1371/journal.pone.0247492.

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Plant polyphenols have an array of health benefits primarily thought to be related to their high content of anti-oxidants. These are commonly undervalued and knowledge of their biological properties have grown exponentially in the last decade. Polyphenol-rich sugarcane extract (PRSE), a natural extract from sugar cane, is marketed as high in anti-oxidants and polyphenols, but its anti-cancer activity has not been reported previously. We show that, PRSE exerts anti-cancer properties on a range of cancer cells including human (LIM2045) and mouse (MC38, CT26) colon cancer cells lines; human lung cancer (A549), human ovarian cancer (SKOV-3), pro-monocytic human leukemia (U937) and to mouse melanoma (B16) cell lines; whereas no effects were noted on human breast (ZR-75-1) and human colon (HT29) cancer cell lines, as well as to human normal colon epithelial cell line (T4056). Anti-proliferative effects were shown to be mediated via alteration in cytokines, VEGF-1 and NF-κB expression.

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Fortes, C., S. Mastroeni, F. Melchi, M. A. Pilla, G. Antonelli, D. Camaioni, M. Alotto, and P. Pasquini. "FC4 Foods rich in polyphenols and N-3 fatty acids decrease cutaneous melanoma risk." Melanoma Research 20 (June 2010): e30. http://dx.doi.org/10.1097/01.cmr.0000382806.14581.52.

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Obrador, Elena, Rosario Salvador-Palmer, Ali Jihad-Jebbar, Rafael López-Blanch, Thanh H. Dellinger, Ryan W. Dellinger, and José M. Estrela. "Pterostilbene in Cancer Therapy." Antioxidants 10, no. 3 (March 21, 2021): 492. http://dx.doi.org/10.3390/antiox10030492.

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Анотація:

Natural polyphenols are organic chemicals which contain phenol units in their structures and possess antitumor properties. However, a key problem is their short half-life and low bioavailability under in vivo conditions. Pterostilbene (3,5-dimethoxy-4′-hydroxystilbene; PT) is a phytoalexin originally isolated from the heartwood of red sandalwood. As recently reported by our group, PT was shown to be effective in the treatment of melanoma. Counterintuitively, PT is not effective (cytotoxic) against melanoma in vitro, and only under in vivo conditions does PT display its anticancer activity. This study elucidated that PT can be effective against melanoma through the inhibition of adrenocorticotropic hormone production in the brain of a mouse, which weakens the Nrf2-dependent antioxidant defenses of melanoma and also pancreatic cancers. This results in both the inhibition of tumor growth and sensitization of the tumor to oxidative stress. Moreover, PT can promote cancer cell death via a mechanism involving lysosomal membrane permeabilization. Different grades of susceptibility were observed among the different cancer cells depending on their lysosomal heat shock protein 70 content, a known stabilizer of lysosomal membranes. In addition, the safety of PT administered i.v. has been evaluated in mice. PT was found to be pharmacologically safe because it showed no organ-specific or systemic toxicity (including tissue histopathologic examination and regular hematology and clinical chemistry data) even when administered i.v. at a high dose (30 mg/kg per day × 23 days). Moreover, new pharmacological advances are being developed to increase its bioavailability and, thereby, its bioefficacy. Therefore, although applications of PT in cancer therapy are just beginning to be explored, it represents a potential (and effective) adjuvant/sensitizing therapy which may improve the results of various oncotherapies. The aim of this review is to present and discuss the results that in our opinion best support the usefulness of PT in cancer therapy, making special emphasis on the in vivo evidence.

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Knez Marevci, Maša, Sašo Bjelić, Barbara Dariš, Željko Knez, and Maja Leitgeb. "The Influence of Extracts from Common Houseleek (Sempervivum tectorum) on the Metabolic Activity of Human Melanoma Cells WM-266-4." Processes 9, no. 9 (August 30, 2021): 1549. http://dx.doi.org/10.3390/pr9091549.

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Human melanoma cells are known as one of the most aggressive cancer cells, and consequently, melanoma is one of the most incurable cancer diseases. There is intense activity in research and development of potential medicines for malignant diseases, including alternative forms of remedies. Therefore, the purpose of our work was testing extracts from the common houseleek (Sempervivum tectorum) grown in Slovenia to establish its impact on human melanoma cells. Namely, we wanted to verify if the extracts inhibit growth of malignant cells and their metabolic activity. Soxhlet, cold solvent, ultrasound, and supercritical extraction methods were applied to obtain S. tectorum extracts. Polyphenols and proanthocyanins content in acquired extracts was determined as well as their antioxidative potential. For a relevant comparison, Chinese (CHI) dried and Slovenian (SLO) lyophilized S. tectorum was used. Results showed that the highest contents of polyphenols and proanthocyanins were yielded from lyophilized material, which also had the highest antioxidative potential. The focus of our work was on analysis of possible inhibition effects of the extracts on human melanoma cells since no past studies were found regarding the possible effects of S. tectorum on metabolic activity of WM-266-4. We established that in a 24-h incubation period, the extracts inhibited metabolic activity of the cells at their concentrations of 20, 10, 4, 2, 1, 0.2, and 0.02 mg/mL. Extract obtained from SLO S. tectorum (ultrasound extraction with acetone as a solvent), which showed promising results of inhibitory effect on the mentioned cells, was further described since the local plant was the focus of our study. CHI S. tectorum extract (Soxhlet extraction with ehtanol:water mixture = 1:1 as a solvent) showed the highest inhibitory effect on human melanoma cells WM-266-4, although both obtained extracts are suitable for their growth inhibition of this specific cell line. Our results suggest inhibitory ability of S. tectorum extracts on the metabolic activity of WM-266-4 metastatic cell line, suggesting their potential use as an anticancer agent.

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Szabo, Katalin, Laura Mitrea, Lavinia Florina Călinoiu, Bernadette-Emőke Teleky, Gheorghe Adrian Martău, Diana Plamada, Mihaela Stefana Pascuta, Silvia-Amalia Nemeş, Rodica-Anita Varvara, and Dan Cristian Vodnar. "Natural Polyphenol Recovery from Apple-, Cereal-, and Tomato-Processing By-Products and Related Health-Promoting Properties." Molecules 27, no. 22 (November 17, 2022): 7977. http://dx.doi.org/10.3390/molecules27227977.

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Анотація:

Polyphenols of plant origin are a broad family of secondary metabolites that range from basic phenolic acids to more complex compounds such as stilbenes, flavonoids, and tannins, all of which have several phenol units in their structure. Considerable health benefits, such as having prebiotic potential and cardio-protective and weight control effects, have been linked to diets based on polyphenol-enriched foods and plant-based products, indicating the potential role of these substances in the prevention or treatment of numerous pathologies. The most representative phenolic compounds in apple pomace are phloridzin, chlorogenic acid, and epicatechin, with major health implications in diabetes, cancer, and cardiovascular and neurocognitive diseases. The cereal byproducts are rich in flavonoids (cyanidin 3-glucoside) and phenolic acids (ferulic acid), all with significant results in reducing the incidence of noncommunicable diseases. Quercetin, naringenin, and rutin are the predominant phenolic molecules in tomato by-products, having important antioxidant and antimicrobial activities. The present understanding of the functionality of polyphenols in health outcomes, specifically, noncommunicable illnesses, is summarized in this review, focusing on the applicability of this evidence in three extensive agrifood industries (apple, cereal, and tomato processing). Moreover, the reintegration of by-products into the food chain via functional food products and personalized nutrition (e.g., 3D food printing) is detailed, supporting a novel direction to be explored within the circular economy concept.

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Більше джерел

Дисертації з теми "Melanoma, Cancer, Tomato, Polyphenols"

D'Angelo, Costantino. "Evaluation of anti-proliferative and antioxidant potential of tomato extract against melanoma." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1133306.

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Abstract Melanoma is a form of skin cancer occurring prevalently, in fair-skinned and lighthaired person; its incidence is constantly increasing and in Italy is the second most frequent cancer males under 50 and third most frequent in female under 50 years. Increasing evidences are demonstrating that antioxidants from vegetables have both antriproliferative activity and ratio-sensiting property on cancer cell. Here, we will investigate the anti-proliferative and ratio-sensitizing potential of polyphenolic fraction from different tomato cultivars in melanoma cells lines. Aim of this work is to expand the existing knowledge on the effects of anti-oxidants and antiproliferative on melanoma cancer cells. The melanoma cancer cell line we used for this study is M14 with mutation in the BRAF gene which is involved in cancer drug resistance. Polyphenolic fraction obtained from our tomatoes extracts has been examined for identification of polyphenols by High Performance Liquid Chromatography technology, and we will study the effects of these compounds on the main pathways to be deregulated in cancer (Rb2, p21/Cip1 and p27/Kip1), according with our published results. Cytotoxicity assay, western blot, qRT-PCR, cell cycle analysis and will be performed to study the impact of these compouds on melanoma cells biology. In the second part of this work we evaluated also the capacity to inhibition of UV-A induced ROS generation in fibroblast cell by tomato extract and the ability to screen UV light and to reduce the harm to DNA caused by free oxygen radicals.

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