Дисертації з теми "Medical applications potential"
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Sharp, Duncan McNeill Craig. "Bioactive scaffolds for potential bone regenerative medical applications." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/9520.
Повний текст джерелаGroombridge, Helen Jane. "Phosphorus - containing ligands with potential applications in medical imaging." Thesis, Queen Mary, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430021.
Повний текст джерелаHauser, Jonathon Charles. "Toxicological examination of metallic and organometallic nanoparticles for potential medical applications." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665462.
Повний текст джерелаRatcliffe, Naomi. "Potential of a compact low energy proton accelertor for medical applications." Thesis, University of Huddersfield, 2014. http://eprints.hud.ac.uk/id/eprint/23711/.
Повний текст джерелаCheesman, Benjamin Thomas. "UV-induced film formation of functionalised siloxanes with potential for medical applications." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559493.
Повний текст джерелаCassen, Mathieu. "Applications of ambulatory body surface potential mapping to the diagnosis of coronary heart disease." Thesis, University of Sussex, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366061.
Повний текст джерелаLiu, Chu Chuan. "Advanced Projection Ultrasound Imaging with CMOS-based Sensor Array: Development, Characterization, and Potential Medical Applications." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/40492.
Повний текст джерелаPh. D.
Buthelezi, Sindisiwe. "Proteomic profiling of Nguni cattle liver tissue using gel and Gel-Free approaches: methodology development and potential applications." Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/3121.
Повний текст джерелаIncludes bibliographical references.
In South Africa, resource-poor farmers mainly depend on livestock farming for their livelihoods, with cattle production being the most important livestock sector. As a consequence of natural selection in stressful conditions, Nguni cattle have been reported to be metabolically superior to other cattle breeds under unfavourable conditions. Using proteomics, with mass spectrometry at the core of the analysis, the objective of this study was to establish a reliable set of methods for the protein profiling of Nguni cattle livers. To achieve this several alternative technologies were employed and their outcomes compared namely, two-dimensional electrophoresis, fractionation by solution phase iso-electric focusing-reversed phase chromatography (IEF-RP), offline strong cation exchange- low pH reversed phase chromatography (SCX-RP) and offline high pH reverse phase-low pH reverse phase chromatography (RP-RP). All solution based methods were coupled to a tandem mass spectrometer. Protein identification was performed using the ParagonTMAlgorithm of Protein Pilot v4.0 as well as PEAKS v6. The IEF-RP and RP-RP methods achieved similar results in terms of number of proteins identified. In addition, proteins that play a role in the urea cycle (which is believed to contribute to the Nguni cattle’s enhanced metabolic ability) were all identified with both techniques. The RP-RP method was selected as the most appropriate method for future research linked to this work and will be used in the next phase of this project, on the basis that it is easier to automate compared to the IEF-RP method. It will be used beyond the scope of this work to compare levels of expression and modification of the liver proteins and their isoforms in Nguni and Hereford cattle grown under adverse environmental conditions, in order to identify those that may contribute to enhanced liver metabolism in Nguni cattle. This will be complemented by the identification and characterisation of potential polymorphisms with in such proteins that can be used to select for this trait during breeding.
Jhala, Ekta. "Investigation of Dosimetric Characteristics and Exploration of Potential Applications of Amorphous Silicon Detector." Thesis, University of Canterbury. Physics and Astronomy, 2006. http://hdl.handle.net/10092/1350.
Повний текст джерелаO'Boyle, Farah. "Investigating the structural integrity of the α-3/5 conotoxin fold and its significance for potential medical applications." Thesis, Queen Mary, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428335.
Повний текст джерелаFernández, del Río Raquel. "Identification of volatile organic compounds in breath associated with liver disease and their potential applications for medical use." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7742/.
Повний текст джерелаHilton, Brian J. "Cationic Steroid Antimicrobials: Applications to Medical Device Coatings, Mechanism of Pro-Osteogenic Properties, and Potential Synergy with Common Antifungals." BYU ScholarsArchive, 2021. https://scholarsarchive.byu.edu/etd/9133.
Повний текст джерелаSukthankar, Pinakin Ramchandra. "Biophysical characterization of branched amphiphilic peptide capsules and their potential applications in radiotherapy." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/18174.
Повний текст джерелаDepartment of Biochemistry and Molecular Biophysics
John M. Tomich
Branched Amphiphilic Peptide Capsules (BAPCs) are peptide nano-spheres comprised of equimolar proportions of two branched peptide sequences bis(FLIVI)-K-KKKK and bis(FLIVIGSII)-K-KKKK that self-assemble in water to form bilayer delimited poly-cationic capsules capable of trapping solutes. We examined the lipid-like properties of this system including assembly, fusion, solute encapsulation, and resizing by membrane extrusion as well as their capability to be maintained at a specific size by storage at 4˚C. These studies along with earlier work from the lab (Gudlur et al. (2012) PLOS ONE 7(9): e45374) demonstrated that the capsules, while sharing many properties with lipid vesicles, were much more robust. We next investigated the stability, size limitations of encapsulation, cellular localization, retention and, bio-distribution of the BAPCs. We demonstrated that the BAPCs are readily taken up by epithelial cells in culture, escape or evade the endocytotic pathway, and accumulate in the peri-nuclear region where they persist without any apparent degradation. The stability and persistence of the capsules suggested they might be useful in delivering radionuclides. The BAPCs encapsulated alpha particle emitting radionuclides without any apparent leakage, were taken up by cells and were retained for extended periods of time. Their potential in this clinical application is being currently pursued. Lastly we studied the temperature dependence of capsule formation by examining the biophysical characteristics of temperature induced conformational changes in BAPCs and examined the structural parameters within the sequences that contribute to their remarkable stability. A region in the nine-residue sequence was identified as the critical element in this process. The ability to prepare stable uniform nano-scale capsules of desired sizes makes BAPCs potentially attractive as delivery vehicles for various solutes/drugs.
De, La Vega José Carlos. "Investigation of the potential application of rhenium in medical imaging." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62822.
Повний текст джерелаScandura, Glenda. "The impact of Ape/Ref1 on hypoxia regulated genes; potential applications for cancer." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/970.
Повний текст джерелаShan, Bin, and 單斌. "Antioxidant and antibacterial capacities of spice and medicinal herb extracts and their potential application as natural foodpreservatives." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B4098784X.
Повний текст джерелаShan, Bin. "Antioxidant and antibacterial capacities of spice and medicinal herb extracts and their potential application as natural food preservatives." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B4098784X.
Повний текст джерелаAlexandra, Olivia. "Potential Application of Multiplex Automated Genome Engineering (MAGE) and One-Step Curing Plasmid System for Environmental Cambodian Enterobacterial Isolates." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-449082.
Повний текст джерелаTian, Peng. "Graphene-based high spatial resolution hall sensors with potential application for data storage media characterisation." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/graphenebased-high-spatial-resolution-hall-sensors-with-potential-application-for-data-storage-media-characterisation(0bb9f59f-a9e2-42e8-ac1f-0adc93e9ae01).html.
Повний текст джерелаDoisy, Anne. "Analyse de la migration et de la déformation cellulaires : application à l'étude du rôle de la protéine CD9/MRP1 dans le carcinome colorectal." Université Joseph Fourier (Grenoble), 1999. http://www.theses.fr/1999GRE10229.
Повний текст джерелаTabuada, Mafalda Sutil. "Potential of marine bacteria to synthesize bioactive compounds for medical applications." Master's thesis, 2018. http://hdl.handle.net/10773/25307.
Повний текст джерелаO cancro do pâncreas é uma das doenças mais letais do mundo. A melhor esperança para reduzir a mortalidade provocada por este cancro reside no diagnóstico e tratamento precoces, mormente na deteção de lesões que podem conduzir ao seu desenvolvimento. Por outro lado, as terapias tradicionalmente aplicadas para combater o cancro do pâncreas têm vários inconvenientes, relacionados nomeadamente com uma eficácia limitada, toxicidade para os pacientes e aquisição de resistência aos medicamentos. Para contrariar esta tendência, tem sido dedicado um maior esforço na descoberta de novos fármacos anti-cancro pancreático, a partir de recursos naturais biológicos. Neste âmbito, organismos provenientes de ambientes marinhos (e.g., microorganismos simbiontes, algas, invertebrados) possuem um amplo potencial genético para a biossíntese de compostos naturais. No entanto, os ecossistemas marinhos estão ainda consideravelmente subexplorados para este propósito. Os simbiontes bacterianos marinhos, em particular, podem produzir vários metabolitos secundários com alto interesse biotecnológico, especialmente para aplicações biomédicas como as direcionadas para o tratamento anticancerígeno. Portanto, os principais objetivos deste trabalho foram: (1) desenvolver uma breve revisão sobre o cancro do pâncreas e suas atuais terapias, bem como sobre os produtos naturais bioativos e vias biossintéticas existentes em microorganismos marinhos; (2) desvendar o potencial de simbiontes bacterianos isolados de cnidários marinhos para sintetizar compostos bioativos contra o cancro do pâncreas. Algumas bactérias têm o potencial de sintetizar novos produtos através da atividade das enzimas policetídeo sintases (PKS), sintetases peptídicas não ribossomais (NRPS), ou uma combinação de ambas. Estas enzimas multifuncionais produtoras de policetídeos (PKs), péptidos não ribossomais (NRPs) ou híbridos PKs-NRPs podem ter várias estruturas químicas e bioatividades (e.g., antimicrobiana, antioxidante, anti-inflamatória, anticancerígena). O rastreio molecular de fragmentos do gene NRPS em simbiontes bacterianos marinhos de cnidários evidenciou a sua presença em 22,3% dos isolados, os quais pertencem aos filos Proteobacteria e Actinobacteria. A maioria das sequências de aminoácidos obtidas para o grupo de bactérias selecionadas por serem potenciais produtores de NRPs, apresentou uma homologia relativamente elevada em relação a sequências de aminoácidos depositadas para NRPS. Além disso, os extratos preparados a partir das frações celulares e sobrenadante de culturas das bactérias selecionadas inibiram significativamente a atividade de uma linha celular humana de adenocarcinoma do ducto pancreático, mediante o ensaio MTT. Assim, o potencial anticancerígeno dos simbiontes bacterianos de cnidários demonstrou ser promissor, pelo que o seu estudo deve ser mais aprofundado no futuro.
Mestrado em Biologia Molecular e Celular
Ferreira, Catarina Metelo Coimbra dos Santos. "Artificial Placenta: Recent Advances and Potential Clinical Applications." Master's thesis, 2018. https://hdl.handle.net/10216/111951.
Повний текст джерелаFerreira, Catarina Metelo Coimbra dos Santos. "Artificial Placenta: Recent Advances and Potential Clinical Applications." Dissertação, 2018. https://repositorio-aberto.up.pt/handle/10216/111951.
Повний текст джерелаGiuntini, Stefano. "Bioconjugates and biomaterials with potential medical applications for the development of new NMR methodologies." Doctoral thesis, 2019. http://hdl.handle.net/2158/1151432.
Повний текст джерелаFerreira, Orlanda Couto. "Plastics and microplastics contamination and biological biomarkers in marine species, human exposure through seafood consumption, and potential applications in Forensic Medicine." Master's thesis, 2020. https://hdl.handle.net/10216/130682.
Повний текст джерелаFerreira, Orlanda Couto. "Plastics and microplastics contamination and biological biomarkers in marine species, human exposure through seafood consumption, and potential applications in Forensic Medicine." Dissertação, 2020. https://hdl.handle.net/10216/130682.
Повний текст джерелаFernandes, Carla Sofia Garcia. "Synthesis of chiral derivatives of xanthones: application as HPLC stationary phases and potential bioactive agents in pharmaceutical and medicinal chemistry." Tese, 2012. https://repositorio-aberto.up.pt/handle/10216/71927.
Повний текст джерелаFernandes, Carla Sofia Garcia. "Synthesis of chiral derivatives of xanthones: application as HPLC stationary phases and potential bioactive agents in pharmaceutical and medicinal chemistry." Doctoral thesis, 2012. https://repositorio-aberto.up.pt/handle/10216/71927.
Повний текст джерела"Isolation of defense proteins from plant seeds and storage organs, and investigation on their potential applications." 2012. http://library.cuhk.edu.hk/record=b5549533.
Повний текст джерела我們在研究中從不同的植物來源成功純化出各種防禦蛋白,包括:小芋頭塊莖中的血凝素、日本長芋中的凝集素、東北紅豆中的血凝素和抗真菌多肽、棕色芸豆中的凝集素、抗真菌多肽和胰蛋白酶抑製劑,玉豆一號中的凝集素以及小斑豆中的胰蛋白酶抑製劑。小芋頭血凝素被發現能誘導脾細胞的有絲分裂反應。日本長芋凝集素和東北紅豆血凝素被發現能對一些腫瘤細胞株(如乳腺癌MCF7細胞及鼻咽癌CNE2細胞)發揮抗增殖的作用。棕色芸豆凝集素能誘導脾臟細胞的有絲分裂反應以及抑制腫瘤細胞株(如乳腺癌MCF7細胞、肝癌HepG2及鼻咽癌CNE1和 CNE2細胞)的生長,而棕色芸豆抗真菌蛋白能抑制數種病原真菌物種的生長。研究這些防禦蛋白的生物活性有助找出其潛在應用價值,如藥用前景。
Infection from pathogens is one of the major health hazards in higher organisms including plants. To defend against harmful invaders, most plants produce a variety of defense proteins including lectins, protease inhibitors, antifungal proteins, ribonucleases and ribosome-inactivating proteins. They may be present in different organs of the plants, such as leaves, roots, seeds and tubers. Some of the plant defense proteins were found to exhibit a variety of biological activities such as anti-tumor activity, anti-bacterial activity and anti-viral activity that act against various plant pathogens and also some human pathogens. Therefore, some plant defense proteins may have potential for therapeutic applications in human diseases, or protecting the crops from infections.
This study involved purification of defense proteins from different plant sources. The proteins that were successfully isolated included a hemagglutinin from small taro tubers, a lectin from Japanese yam tubers, a lectin and an antifungal peptide from northeast red beans, a lectin, an antifungal peptide and a trypsin inhibitor from brown kidney beans, a lectin from French bean cultivar no. 1 and a trypsin inhibitor from mini pinto beans. The small taro hemagglutinin was found to induce mitogenic response in splenocytes. The Japanese yam lectin and northeast red bean hemagglutinin were found to exert anti-proliferative activity toward some tumor cell lines including MCF7 and CNE2 cells. The brown kidney bean lectin induced a mitogenic response from murine splenocytes as well as inhibited the growth of tumor cell lines including MCF7, HepG2, CNE1 and CNE2 cells, while the brown kidney bean antifungal protein inhibited the growth of several pathogenic fungal species including M. arachidicola, S. turcica and B. maydis. Studying the biological activities of these defense proteins helps to find out their potential applications like therapeutic uses.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Chan, Yau Sang.
Thesis (Ph.D.)--Chinese University of Hong Kong, 2012.
Includes bibliographical references (leaves i-xvii).
Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Abstract also in Chinese.
Abstract --- p.i-ii
論文摘要 --- p.iii
Acknowledgements --- p.iv
List of Publications --- p.v
Table of Contents --- p.vi-vii
List of Figures --- p.viii-ix
List of Tables --- p.x
List of Abbreviations --- p.xi
Chapter Chapter 1 --- Introduction on plant defense proteins
Chapter 1.1 --- General introduction to plant defense proteins --- p.1-2
Chapter 1.2 --- An overview on lectins --- p.3-18
Chapter 1.2.1 --- History of lectins --- p.3-6
Chapter 1.2.2 --- Classification of lectins --- p.7-11
Chapter 1.2.3 --- Biological activities of lectins --- p.12-16
Chapter 1.2.4 --- Applications of plant lectins --- p.16-18
Chapter 1.3 --- An overview on defensins --- p.18-25
Chapter 1.3.1 --- Types of defensins --- p.18-21
Chapter 1.3.2 --- Mechanism of anti-microbial activity of defensins --- p.22-23
Chapter 1.3.3 --- Application of defensins --- p.23-25
Chapter 1.4 --- An overview on trypsin inhibitors --- p.25-38
Chapter 1.4.1 --- Serpins --- p.26-28
Chapter 1.4.2 --- Kunitz-type protease inhibitors --- p.29-31
Chapter 1.4.3 --- Bowman-Birk protease inhibitors --- p.32-34
Chapter 1.4.4 --- Physiological functions of protease inhibitors --- p.35-38
Chapter 1.5 --- Aim of study --- p.38-41
Chapter Chapter 2 --- Isolation and characterization of a hemagglutinin from small taros and a lectin from yam tubers
Chapter 2.1 --- Introduction --- p.42-45
Chapter 2.2 --- Materials and Methods --- p.46-55
Chapter 2.3 --- Results --- p.56-78
Chapter 2.4 --- Discussion --- p.79-84
Chapter Chapter 3 --- Isolation and characterization of two defense proteins from seeds of Phaseolus vulgaris cv. “northeast red bean“
Chapter 3.1 --- Introduction --- p.85-86
Chapter 3.2 --- Materials and Methods --- p.87-93
Chapter 3.3 --- Results --- p.93-119
Chapter 3.4 --- Discussion --- p.120-129
Chapter Chapter 4 --- Isolation and characterization of three defense proteins from seeds of Phaseolus vulgaris cv. “brown kidney bean“
Chapter 4.1 --- Introduction --- p.130-131
Chapter 4.2 --- Materials and Methods --- p.131-136
Chapter 4.3 --- Results --- p.136-175
Chapter 4.4 --- Discussion --- p.176-189
Chapter Chapter 5 --- Isolation and characterization of a lectin from French bean cultivar no. 1 beans and a trypsin inhibitor from mini pinto beans
Chapter 5.1 --- Introduction --- p.190-191
Chapter 5.2 --- Materials and Methods --- p.191-194
Chapter 5.3 --- Results --- p.195-212
Chapter 5.4 --- Discussion --- p.213-221
Chapter Chapter 6 --- General discussion
Chapter 6.1 --- Summary on purification protocols of the defense proteins in the study --- p.222-228
Chapter 6.2 --- Chemical properties of the defense proteins in the study --- p.228-232
Chapter 6.3 --- Biological activities of the defense proteins in the study --- p.232-238
Chapter 6.4 --- Potential application of these defense proteins and future perspectives --- p.238-242
References --- p.i-xvi
Sousa, Adelaide Patrícia Teles de. "Chalcones targeting neutrophils for the modulation of oxidative stress in physiological and hyperglycemic conditions. Potential application in the treatment of diabetes mellitus." Master's thesis, 2019. https://hdl.handle.net/10216/124455.
Повний текст джерелаSousa, Adelaide Patrícia Teles de. "Chalcones targeting neutrophils for the modulation of oxidative stress in physiological and hyperglycemic conditions. Potential application in the treatment of diabetes mellitus." Dissertação, 2019. https://hdl.handle.net/10216/124455.
Повний текст джерела(9356939), Jui-wei Tsai. "Digital Signal Processing Architecture Design for Closed-Loop Electrical Nerve Stimulation Systems." Thesis, 2020.
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