Дисертації з теми "MDNA"
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Davidson, Alexander F. "Elucidating the mechanism of localised mDNA translation during Drosophila oogenesis." Thesis, University of Oxford, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711933.
Повний текст джерелаCosta, José Luiz da. "Determinação de 3,4-metilenodioximetanfetamina (MDMA - Ecstasy), 3,4-metilenodioxietilanfetamina (MDEA - Eve) e 3,4-metilenodioxianfetamina (MDA) em fluidos biológicos por cromatografia líquida de alta eficiência: aspecto forense." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-11032005-190039/.
Повний текст джерелаThere is a worldwide increase in the use of the synthetic drugs of abuse known as designer drugs. The main representatives of this class are Ecstasy or 3,4-methylenodioxymethamphetamine (MDMA) and Eve or 3,4- methylenodioxyethylamphetamine (MDEA), substances with stimulant and hallucinogenic effects. In Brazil media coverage of them is on the increase and their recreational is in evidence by the growing numbers of patients who seek treatment at drug treatment centers. This paper validates the analytical methodology for the laboratory diagnosis of the use of MDMA, MDEA and their product of biotransformation, 3,4-methylenodioxyamphetamine (MDA), in whole blood and urine by high performance liquid chromatography with fluorescence. The developed methods showed good linearity, precision, accuracy, yield and capacity to detect analytes even when present in low concentrations, which enables its application in cases high intoxication as well as in cases of the recreational use of these drugs of abuse.
Cormick, Justin. "Isotope ratio analysis of 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethylamphetamine (MDMA) synthesised from helional." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/415810.
Повний текст джерелаThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Environment and Sc
Science, Environment, Engineering and Technology
Full Text
Wieliczko, Monika J. "Psychological effects of MDMA." Thesis, Canterbury Christ Church University, 2016. http://create.canterbury.ac.uk/14928/.
Повний текст джерелаGiesen, Ralf. "Mathematische Modellierung des MDEA-Absorptionsprozesses." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973450738.
Повний текст джерелаAnneken, John H. "Glutamate and MDMA Neurobehavioral Toxicity." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1353342344.
Повний текст джерелаBósio, Graziela Costa. "Contribuição individual dos enatiômeros isolados da 3,4-metilenodioximetanfetamina (MDMA) comparativamente com a mistura racêmica no estresse oxidativo hepático, renal e estriatal de ratos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-19062013-160903/.
Повний текст джерелаMDMA (3,4-methylenedioxymethamphetamine) is an amphetamine derivate that is largely used for recreational purpose due to its feeling of euphoria, energy and the desire to socialize. Although MDMA has the reputation of being safe, a growing number of clinical reports and experimental studies indicate that MDMA can produce toxicity in the CNS, kidney, liver and heart.Although MDMA is present in ecstasy tablets as a racemate (a 50% mixture of its enantiomer) it has an enantioselective metabolism; in rats, the S-enantiomer is metabolized faster than the R-enantiomer and it is the more active pharmacological form. As the MDMA biotransformation can produce reactive metabolites, probably the R form has a greater potential to generate ROS / ERN and oxidative damage in tissues than the S. In humans, the opposite occurs. Therefore, this aim of the present study was to evaluate the individual contribution of single MDMA enantiomers, compared to racemic mixture in liver, kidney and striatal rats oxidative stress. Adult male Wistar rats (180- 220g) will be divided into four groups: control treatment (saline), racemic MDMA, R-MDMA and S-MDMA (two consecutive doses 24h apart with 10mg/kg, gavage). Oxidative stress status parameters will be used to measure malondialdehyde formation, the reduced glutathione levels determination and the glutathione-S-transferase activity. The enantiomers of racemic MDMA were separated by liquid chromatography high-efficiency chiral stationary phase. The enantiomers showed a high degree of purity and a good recovery. Our results showed that the total glutathione content in liver of rats in R,S-MDMA and R-MDMA group was significantly lower than the control and S-MDMA, revealing that the R-enantiomer that contributes to hepatic glutathione depletion induced by the racemic mixture. The high reactivity of the R enantiomer in the liver can also be observed in animals treated with R-MMDA, since there was a significantly increased production of MDA, compared with other treated and control groups. The total glutathione content in kidney was significantly lower for all treated groups compared with control. With respect to the striatum, only animals treated with the S isomer alone showed a significant decrease in GST activity compared to other treatment and control groups. Taking all these data together, this study shows that the isolated enantiomers of MDMA can act differently with regard to the redox state, mainly in the liver, since the R isomer was the largest contributor to oxidative damage.
Chaves, Rafael Alves. "Aspectos e MDA." Florianópolis, SC, 2004. http://repositorio.ufsc.br/xmlui/handle/123456789/87201.
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As principais contribuições deste trabalho consistem em analisar o potencial do uso conjunto das abordagens MDA e orientação a aspectos, e propor extensões à UML para comportar a criação de modelos executáveis usando o paradigma de aspectos.
Chakma, Amitabha. "Studies on DEA and MDEA degradation." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26971.
Повний текст джерелаApplied Science, Faculty of
Chemical and Biological Engineering, Department of
Graduate
Christian, Michael. "Exploring MDMA and its therapeutic potential." Honors in the Major Thesis, University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/672.
Повний текст джерелаB.S.
Bachelors
Sciences
Psychology
Bhide, Nirmal S. "Tolerance to MDMA-induced serotonergic neurotoxicity." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1267719790.
Повний текст джерелаPalhol, Fabien. "Contribution à l'étude des saisies d'Ecstasy par spectrométrie de masse de rapports isotopiques : apport du rapport 15N/14N." Nantes, 2002. http://www.theses.fr/2002NANT2057.
Повний текст джерелаYubero, Lahoz Samanta 1985. "MDMA pharmacology in humans and serotonergic effects." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/145481.
Повний текст джерелаLa 3,4-metilendioximetanfetamina (MDMA, èxtasi) és una de les drogues més consumides al món. Aquesta droga inhibeix el seu propi metabolisme, inhibint un enzim polimòrfic del fetge, el CYP2D6, que és el responsable de l’eliminació d’una quarta part dels medicaments. Aquest fet té implicacions clíniques rellevants, ja que els consumidors de MDMA presenten una prevalença de psicopatologia més alta respecte a la població no consumidora, i moltes de la patologies psiquiàtriques es tracten amb fàrmacs substrats d’aquest enzim. A més, encara no s’ha discernit com aquesta droga pot ser eliminada de l’organisme, inclús després d’haver-ne consumit dosis de manera repetida. Així doncs, la primera part d’aquesta tesi es centra en estudiar l’autoinhibició de la MDMA determinant l’activitat de diferents enzims del fetge, en homes i dones. Encara que la farmacologia de la MDMA està descrita a fons, no està del tot clar quin és el seu mecanisme d’acció. La MDMA interactua amb el sistema serotonèrgic de diverses maneres, però avui en dia és molt difícil estudiar tècnicament el sistema serotonèrgic en el cervell humà. Les tècniques d’imatge estan limitades per molts factors, i per tant, seria molt útil tenir un índex perifèric a la sang de l’activitat serotonèrgica al sistema nerviós central. La segona part d’aquest tesi s’enfoca en el desenvolupament de tècniques per determinar a diferents nivells si el transportador de la serotonina a les plaquetes podria ser un bon biomarcador perifèric de la seva activitat al cervell, i d’aquesta manera veure si el sistema serotonèrgic està implicat en el mecanisme d’acció de la MDMA.
Lebsanft, Heike Birgit. "MDMA ("Ecstasy") in Tiermodellen des Morbus Parkinson." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972748601.
Повний текст джерелаABLE, JESSICA ANN. "MDMA ADMINISTRATION AFFECTS COGNITION IN THE RAT." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1147890602.
Повний текст джерелаBARBOSA, Paulo Eduardo e. Silva. "MDA-VERITAS: uma arquitetura MDA estendida para transformações de sistemas concorrentes preservadoras de semântica." Universidade Federal de Campina Grande, 2011. http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/1764.
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MDA é uma tendência de desenvolvimento de software que visa alterar o foco e os esforços dos modelos de desenvolvimento atuais. O método de implementação deixa de ser apenas a produção e código, e passa a também envolver modelos, metamodelos e transformações. Atualmente, essa abordagem tem sido diversificada com a inclusão de novos paradigmas que vão bem além do uso exclusivo dos padrões da OMG, como proposto originalmente. Contudo, a arquitetura MDA ainda sofre com a falta de formalização de alguns de seus artefatos e processos, levando a vários tipos de questionamentos. Um exemplo pertinente de questionamento se dá sobre o alto grau de ambigüidade dos modelos e transformações, originando problemas de baixa confiabilidade. Uma das conseqüências disso é o fato de que atualmente não existe uma maneira de garantir que transformações MDA sejam preservadoras de semântica, e nem que seus modelos envolvidos nas transformações sejam formais o suficiente para se permitir o uso de técnicas deverificação de equivalência, gerando críticas sobre a eficácia dessa abordagem. Esta tese de doutorado propõe lidar com esse problema, incorporando abordagens consolidadas de métodos formais na arquitetura MDA, tendo como contexto específico o desenvolvimento de software para sistemas embarcados com características de concorrência. Propomos extensões para parte da arquitetura MDA para que se possa construir modelos semânticos que representem aspectos estáticos e dinâmicos, ambos essenciais na semântica dos modelos envolvidos nas transformações e nos mecanismos de verificação de equivalência desses modelos. Com isso,obtemos a verificação de equivalência em transformações envolvendo modelos de sistemas concorrentes. Como avaliação do trabalho, provas de conceito, estudos de caso e avaliação experimental seguindo a abordagem GQM, envolvendo parcerias na academia e na indústria através de sistemas reais, foram implementados e avaliados. Verificamos equivalência entre modelos ao nível de transformações PIM-para-PIM, PSM-para-PSM e PIMpara-PSM como modelos de sistemas concorrentes descritos em redes de Petri e algumas de suas extensões.
MDA is a software development trend that aims to shift the focus and efforts of the current development methodologies. The implementation method changes from only code production to the usage of models, metamodels and transformations. Currently, this approach has been diversified with the inclusion of new paradigms that go beyond the only use of the MDA standards, as originally proposed. However, the MDA architecture still suffers from the lack of formalization of its artifacts and processes, leading to several sorts of questions. An important example of question is about the high ambiguity levels of models and transformations, originating problems of low reliability. One of the main consequences of this problem is the fact that still there is no way to ensure that MDA transformations are semantics preserving and neither the involved models are formal enough to allow the use of equivalence verification techniques, criticizing the effectiveness of this approach. This thesis proposes to deal with this problem by incorporating well consolidated formal methods techniques in the MDA architecture, having as specific context the software development for embedded systems with concurrent features. We propose extensions to part of the MDA architecture in order to construct semantic models to represent static and dynamic aspects, both essentials in the semantics of the involved models in the transformations and in the verification mechanisms of these models. With this, we achieve the verification of equivalence in transformations with models of concurrent systems. Asevaluationofthework,conceptualproofs, case studies and an experimental evaluation following the GQM approach, involving partners in the academy and industry, were implmented and evaluated. We verify models equivalence at the level of PIM-to-PIM, PSM-to-PSM and PIM-to-PSM transformations with models of concurrent systems described and inPetri nets and some of its extensions.
Turner, Alexandra. "What is the difference between Ecstasy and MDMA?" Thesis, Anglia Ruskin University, 2016. http://arro.anglia.ac.uk/701011/.
Повний текст джерелаTurner, Alexandra. "What is the difference between Ecstasy and MDMA?" Thesis, Anglia Ruskin University, 2016. https://arro.anglia.ac.uk/id/eprint/701011/1/Alexandra_Turner_Thesis_03.03.2016.pdf.
Повний текст джерелаHuff, Courtney L. M. S. "MDMA and Glutamate: Implications for Hippocampal GABAergic Neurotoxicity." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460444662.
Повний текст джерелаBen, Hamida Sami. "Interactions entre MDMA et éthanol : effets comportementaux, physiologiques et pharmacologiques." Strasbourg, 2009. http://www.theses.fr/2009STRA6036.
Повний текст джерелаEcstasy is commonly used in combination with other drugs, and particularly with alcohol (ethanol). Previous studies performed in the laboratory have shown in Long- Evans rats that ethanol (EtOH) potentiated 3,4-methylenedioxymethamphetamine (MDMA)-induced hyperlocomotion, while protecting against its hyperthermic effects. The present work, in continuation of these observations, provided a fundamental understanding of the pharmacokinetic and pharmacodynamic interactions between MDMA and ethanol. For this purpose, we used physiological, behaviour and pharmacological approaches, complemented by functional neuroimaging studies. We showed that the effects of the interaction between MDMA and ethanol were different from those of the interaction between EtOH and amphetamine or cocaine. We also showed that the effects of ethanol on MDMA-induced hyperthermia were dependent on ambient temperature and on MDMA administration conditions. Finally, we demonstrated that dopamine transmission in the nucleus accumbens was involved in psychomotor action of the combination of MDMA and ethanol. It is probable that MDMA-induced dopamine release within the nucleus accumbens is probably increased by co-administration of ethanol, and this increase might explain the reinforcing effect of the combination of MDMA and ethanol
Fonsart, Julien. "Toxicité aiguë, métabolisme et pharmacocinétique de la 3,4-méthylènedioxyméthamphétamine (MDMA, ecstasy) : influence du sexe chez le rat Sprague-Dawley." Paris 5, 2008. http://www.theses.fr/2008PA05P651.
Повний текст джерелаUse of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), an illicit designer drug that can lead to life-threatening hyperthermia and serotonin syndrome, has greatly increased over the last years. Men appear to be more sensitive to acute toxicity than are women, with a 4:1 sex-ratio of lethality, and so to its physiological adverse effects. Some studies also reported similar phenomenon in rodents. The present study demonstrates sex-difference in LD50 (18 vs. 42. 5 mg/kg) and hyperthermic effect (0. 9°C) of MDMA in Sprague-Dawley rats, also evaluating metabolic differences between sexes affecting pharmacokinetics of the drug. N-demethylation of MDMA to MDA, a more active and toxic metabolite, is 3. 3-fold more important in vitro using male rats hepatic microsomes, while CYP1A2 catalysing the reaction is twice more active compared to females. Such metabolic discrepancy modifies in a sex-dependent manner the pharmacokinetics of MDMA and its metabolites, which have been evaluated using a liquid chromatography-mass spectrometry method specially designed for the present study and allowing simultaneous quantification of MDMA and its main metabolites. MDA plasma levels appear to be higher in males, whatever the route of administration (subcutaneous or intravenous) of MDMA, caused by a higher metabolism of MDMA than of MDA, and leading to a longer systemic exposure of males rats. Such differences could explain observed sex-difference in lethality, as LD50 of MDA did not differ between sexes. The data suggest that the metabolic differences in amphetamine-related drugs are of major importance for their toxicity, and especially for MDMA
Soares, Inali Wisniewski. "PM-MDA: um método para o desenvolvimento de modelos de plataforma no contexto da MDA." Universidade Tecnológica Federal do Paraná, 2012. http://repositorio.utfpr.edu.br/jspui/handle/1/716.
Повний текст джерелаThis thesis proposes a method called PM-MDA for the development of Platform Models in the context of Model Driven Architecture (MDA). The PM-MDA method focuses on the development of embedded software projects based on Real-Time Operating Systems (RTOS). Additionally, this study defines a UML 2.0 Profile for Modeling Application and Platform of Embedded Software (PROAPES), which is used in the PM-MDA method. Such profile defines a set of stereotypes to generically describe Platform Models (PMs) and Platform Independent Models (PIMs). Further, extensions are defined in this profile, e.g. the PROAPESX profile, allowing the modeling of PMs into versions of the X RTOS Real-Time Kernel and associated hardware. In its turn, the PROAPES profile enables the link of a PIM to a PM, allowing these models to be entered as input attributes in a Model Transformation. In the context of MDA, this profile is a platform metamodel for building PMs, i.e., a metamodel of a family of similar platforms. In this way, a PM is used as a fundamental part in the development of embedded software in the MDA approach by providing means of obtaining platform independence. In current MDA approaches, model transformations implicitly employ PMs. As the concerns regarding the platform are not separated from the concerns related to model transformations, for each required platform there must be one or more corresponding model transformations that are configured specifically for that platform. This results in model transformation processes that are expensive and difficult to be automated. In some application domains such as embedded systems, the use of MDA is more motivating because of the heterogeneity of platforms and the complexity of these systems. The PM-MDA method, which makes use of the PROAPES profile, aims to systematize the process of creating and providing platform models separated from the model transformation process, enabling the generation of efficient and adaptable model transformations.
Medina, Krista Lisdahl. "Ecstasy (MDMA) Exposure and Neuropsychological Functioning: A Polydrug Perspective." Cincinnati, Ohio : University of Cincinnati, 2005. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1112218607.
Повний текст джерелаOrejarena, Maria Juliana. "Neurobiological mechanisms involved in MDMA-Seeking behaviour and relapse." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7229.
Повний текст джерела(+) 3,4-methylenedioxymethamphetamine (MDMA), commonly known as "ecstasy", is currently a highly consumed drug with liability to produce addiction in some individuals. MDMA induces unique psychoactive effects that clearly distinguish it from hallucinogenic or psychostimulant drugs. MDMA mainly enhances the activity of both the serotonergic and the dopaminergic system in the esolimbic brain reward pathways. However, the neurobiological mechanisms underlying its possible addictive properties are still not fully understood. In the present work, we have contributed to this subject by establishing that the serotonin 5-HT2A receptor, in contrast to what has been observed for other drugs of abuse, is critical for MDMA-induced reinforcement. Moreover, the pharmacological blockade of this receptor can prevent cue-induced relapse. This effect is possibly mediated by its excitatory control over basal and MDMA-induced increase in midbrain dopamine, as supported by our microdialysis data. Furthermore, we have also shown that MDMA can act as an interoceptive cue to induce relapse to cocaine-seeking behaviour. Additionally, we demonstrated differential changes at the level of the dopaminergic brain reward pathway and gene expression changes in different brain areas, following self-administeredMDMAin comparison to passive administration. These results underpin the impact of a learning component in the rewarding/reinforcing properties of MDMA, and provide new evidence for the serotonergic involvement in MDMA-seeking behavior and relapse.
Kuypers, Kim Paula Colette. "Psychedelic bliss: memory and risk taking during MDMA intoxication." [Maastricht : Maastricht : Universiteit Maastricht ] ; University Library, Universiteit Maastricht [host], 2007. http://arno.unimaas.nl/show.cgi?fid=8303.
Повний текст джерелаStraiko, Megan M. W. "Consequences of ± 3,4-methylenedioxymethamphetamine (MDMA) administration in the rat." Cincinnati, Ohio : University of Cincinnati, 2006. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1153777964.
Повний текст джерелаTitle from electronic thesis title page (viewed Sept. 11, 2007). Includes abstract. Keywords: MDMA; neurotoxicity; C-tau; sex behavior; nitric oxide. Includes bibliographical references.
Rodsiri, Ratchanee. "MDMA : binge use and functional outcomes in the rat." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/13386/.
Повний текст джерелаEaston, Neil. "3,4-Methylenedioxymethamphetamine (MDMA, Ecstacy) neurotoxicity : role of thioether adducts." Thesis, Nottingham Trent University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272853.
Повний текст джерелаSharifimonfared, Ghazaleh. "Pathways through MDMA use : a qualitative life story study." Thesis, University of Hull, 2016. http://hydra.hull.ac.uk/resources/hull:15621.
Повний текст джерелаWareing, M. "Working memory and executive deficits among MDMA (Ecstasy) users." Thesis, Edge Hill University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439660.
Повний текст джерелаRoberts, C. A. "Neurophysiological correlates of ecstasy/MDMA use on executive functioning." Thesis, Liverpool John Moores University, 2014. http://researchonline.ljmu.ac.uk/4524/.
Повний текст джерелаHatala, Elaine M. "Characteristics and Predictors of Ecstasy (MDMA) Use During College." Diss., Temple University Libraries, 2008. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/882.
Повний текст джерелаPh.D.
This cross-sectional investigation examined characteristics of ecstasy use during college and associations between ecstasy use during college and demographic factors, family functioning, mental health, and stage of change for ecstasy use. In addition a multivariate model was developed to predict characteristics of ecstasy use during college. An electronic survey was sent to all undergraduate students enrolled at a large urban university in the mid-Atlantic region of the United States during the spring of 2007. Demographic factors and characteristics of ecstasy use were examined using standardized measures employed in national drug use surveys and by the World Health Organization. Measures associated specifically with ecstasy use during college were developed for this investigation. Family functioning was measured with the Parent Adolescent Communication Scale. Mental health was measured with the K6 screening instrument for nonspecific psychological distress. Stage of change was measured with a five-stage algorithm. The final sample for analysis consisted of 194 participants who reported ecstasy use during college and 2849 participants who reported no ecstasy use during college. Data were described using conventional descriptive statistics, chi-square statistics and non-parametric statistics. A logistic regression model was used to identify variables associated with ecstasy use during college. Based on the results, the following generalized conclusions were drawn: ecstasy continues to be used by college students at large urban universities in the mid-Atlantic region of the United States; because the majority of college students reported using ecstasy for the first time during college and also reported using ecstasy for up to two years, it appears that the college environment is a contextual factor for ecstasy use; lower family communication is associated with ecstasy use during college; psychological distress is associated with ecstasy use during college; being white (versus non-white), male (versus female) and having low or moderate (versus high) family communication each is independently associated with ecstasy use during college; differences in stage of change for ecstasy use among ecstasy users and the demographic profile of ecstasy users compared to non-ecstasy users suggest that prevention, education and intervention efforts should be designed to match the unique factors associated with ecstasy use during college.
Temple University--Theses
Gabay, Anthony Stuart. "An investigation of social cognition using psilocybin and MDMA." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/an-investigation-of-social-cognition-using-psilocybin-and-mdma(dedc1c2c-5023-4cba-9994-6178214334f3).html.
Повний текст джерелаGall, Dariusz, and Michał Molenda. "EDOC to EJB transformations within MDA." Thesis, Blekinge Tekniska Högskola, Avdelningen för programvarusystem, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-4159.
Повний текст джерелаŠkultinas, Tomas. "MDA panaudojimo programinės įrangos kūrimui tyrimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20050524_163850-89727.
Повний текст джерелаMichl, Zbyněk. "T-Mobile MDA II v Linuxu." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2009. http://www.nusl.cz/ntk/nusl-236630.
Повний текст джерелаBecker, Steffen. "Coupled model transformations for QoS enabled component-based software design." Karlsruhe Univ.-Verl. Karlsruhe, 2008. http://d-nb.info/990667650/04.
Повний текст джерелаAlmeida, Stella Pereira de. "Primeiro perfil do usuário de "êxtase" (MDMA) em São Paulo." Universidade de São Paulo, 2000. http://www.teses.usp.br/teses/disponiveis/47/47132/tde-17012006-152155/.
Повний текст джерелаThe present study was aimed at identifying patterns of ecstasy (MDMA) use in the city of São Paulo. Ecstasy users were recruited through the snowball technique. Using the same technique, a control group of subjects that had never tried the drug (non users) was recruited among individuals sharing with users a similar life style. Users (N=52) and non users (N=52) were interviewed in order to obtain socio-demographic data and data on use of psychoactive drugs; users were also questionned as to the circumstances surrounding their use of the drug. Besides, levels of anxiety, depression and impulsiveness were assessed through Spielberger's IDATE Trace Inventory, Beck's Depression Inventory and Barratt Impulsiveness Scale. Both users and non users revealed similar socio-demographic characteristics: most subjects were middle class young heterosexual single men and women who had a college degree. Multiple drug use was more frequent among users than among non users. Other features that were significantly more accentuated among users than among non users were the presence of tattoos and piercings, the frequency to raves and the preference for electronic music. Beck Inventory results pointed to significantly lower depression scores among users. No differences were observed between groups in anxiety and impulsiveness scores. Ecstasy consumption patterns among users are similar to those reported in Europe and Australia: most subjects take one or two pills per episode, during weekends or vacations, usually with company and in social gatherings such as dancings, raves and parties. The drug is predominantly acquired from friends or acquaintances in these same spots. Most users reported consuming ecstasy in combination with other psychoactive drugs, particularly marihuana. The socio-demographic features of users as well as the way they buy and consume the drug suggest that the present pattern of use is not connected to illegal or marginal activities. Harm reduction strategies are suggested in case of ecstasy's use increases and spreads among the young population of the city.
Agostinho, Túlio de Castro. "Análise voltamétrica de 3,4-metilenodioximetanfetamina." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/59/59138/tde-12122012-102825/.
Повний текст джерелаThe main purpose of the present study was to investigate the voltammetric behavior of 3,4-methylenedioxymethanphetamine (MDMA), the psychoactive substance of ecstasy, a drug that has become increasingly popular among drug users. The high performance liquid chromatography technique was employed in order to isolate the substance from ecstasy samples obtained in partnership with Polícia Científica de Ribeirão Preto and also the mass spectrometry technique was employed to confirm the presence of MDMA. The voltammetric studies were performed using the three electrodes system, being glassy carbon as the working electrode, Ag/AgCl as the reference electrode and platinum wire as counter electrode. The electrochemical behavior of the substance was investigated using different voltammetric techniques: Cyclic, differential pulse and square wave voltammetry modalities, in which an anodic peak was observed at Ep = +1,1 V. The voltammetric parameters were optimized in order to make the analysis faster and more sensitive, without loss of quality and intensity of the voltammetric signal. With the voltammetric parameters optimized, analytical curves of the studied analyte were built for the different voltammetric techniques. It was possible to determine the content of MDMA in the five different ecstasy samples utilized, in which four showed MDMA with contents ranging from 3 to 10% (m/m) and one in which no MDMA was observed but another drug, lidocaine.
Wagenborg, David. "MDA development by design or by policy." Thesis, Monterey, Calif. : Naval Postgraduate School, 2008. http://bosun.nps.edu/uhtbin/hyperion-image.exe/08Mar%5FWagenborg.pdf.
Повний текст джерелаThesis Advisor(s): Gallup, Shelley. "March 2008." Description based on title screen as viewed on May 16, 2008. Includes bibliographical references (p. 59-60). Also available in print.
Peat, Jonathan David. "The human Mda-7 / IL-24 gene." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398630.
Повний текст джерелаBeveridge, Thomas James Ramsey. "An investigation into the neuronal activity induced by direct and indirect 5-HTâ‚‚ agonists as indicated by Arc mRNA." Thesis, De Montfort University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271936.
Повний текст джерелаTheodoro, Júnior Marcelo Brandão. "MDWA : Uma abordagem guiada por modelos para desenvolvimento de software Web." Universidade Federal de São Carlos, 2012. https://repositorio.ufscar.br/handle/ufscar/515.
Повний текст джерелаUniversidade Federal de Sao Carlos
Software development techniques continually evolve in order to improve development and maintenance processes in addition to lower costs and higher quality. The goal of MDD is to reduce the semantic distance between a problem and its solution specification. Therefore MDD focuses on high-level abstraction modeling and successive model transformations, until finally, generate code. Studies assert that model-driven development can be significantly more efficient than traditional source code-driven software development and still reduce the possibility of occurrence of several problems during the software life-cycle. Likewise, Web engineering can also be benefited by MDD adoption, especially when supported by approaches that facilitate MDD use. Web development is usually agile with frequent releases, these approaches must be flexible to adapt to this context. However, generally, the approaches proposed by the academic community have complex processes which involve many different model definitions, programming languages, plug-ins and IDEs. These features contradict the practices adopted by Web developers. This paper presents the MWDA (Model-Driven Web Applications) approach that provides a simple process to support model-driven web development. This approach does not depend on tools, technologies or plug-ins and encourage combination with other forms of reuse and development processes. Furthermore, the Ruby- MDWA was developed with Ruby language and Ruby on Rails framework support, in order to create Web applications with MDWA assistance. This tool provides a set of textual models and defines M2M and M2C transformation tools, maintaining the requirements traceability since its specification to its construction and further maintenance. In order to show the use of the approach and tool, it was performed a real study case with a software company, from São Carlos SP, where a project management system was developed. In parallel, two experiments were conducted with undergraduate students in Computer Science and Computer Engineering and a Masters in Computer Science, to evaluate the gains and limitations of the Ruby-MDWA tool.
As técnicas de desenvolvimento de software evoluem continuamente com a finalidade de melhorar processos de construção e manutenção de software, além de obter ganhos em tempo, custo e qualidade. O objetivo do MDD é reduzir a distância semântica entre um problema e a especificação de sua solução. Para isso, MDD tem enfoque na modelagem de alto nível de abstração e em sucessivos refinamentos dos modelos construídos em artefatos mais detalhados, até enfim, gerar código. Há afirmações de que o desenvolvimento orientado a modelos pode ser significativamente mais eficiente que o desenvolvimento tradicional guiado por código fonte, além de reduzir a possibilidade de ocorrência de uma série de problemas durante o ciclo de vida do software. Da mesma forma, a engenharia de aplicações Web também pode ser beneficiada pela adoção de MDD, em especial com o apoio de abordagens que facilitem sua utilização. Como o desenvolvimento de aplicações Web comumente é ágil e com publicações freqüentes, essas abordagens devem ser flexíveis para que se adaptem a esse contexto. Entretanto, em geral, as abordagens propostas pela comunidade acadêmica apresentam processos complexos que envolvem diversos modelos, linguagens de programação, plug-ins e ambientes de programação. Essas características contrariam as práticas aprovadas pelos desenvolvedores Web. Esta dissertação apresenta a abordagem MDWA (Model-Driven Web Applications) que fornece um processo simples para desenvolvimento de software Web com apoio de MDD. A abordagem não depende de ferramentas, tecnologias ou plug-ins e estimula a combinação com outras formas de reuso e processos de desenvolvimento. Além disso, foi construída uma ferramenta, denominada Ruby-MDWA, baseada na linguagem Ruby e no framework Ruby on Rails destinada à criação de aplicações Web com auxílio da abordagem MDWA. Essa ferramenta fornece um conjunto de quatro modelos textuais e define transformadores M2M e M2C, que mantém a rastreabilidade de um requisito desde sua especificação até sua construção e posterior manutenção. Para mostrar o uso da abordagem e da ferramenta, foi realizado um estudo de caso real em conjunto com uma empresa de software de São Carlos SP, onde um sistema de gerenciamento de projetos foi desenvolvido. De forma paralela, foram conduzidos dois experimentos com alunos de graduação em Bacharelado em Ciência da Computação e Engenharia de Computação e mestrado em computação da UFSCar, visando avaliar os ganhos e as limitações da ferramenta Ruby-MDWA.
Fallon, John Kevin. "Stereospecific analysis and enantiomeric disposition of 3,4-methylenedioxymethamphetamine (MDMA) in man." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313776.
Повний текст джерелаLeão, Anabela Pereira. "Lesões musculares esqueléticas induzidas pela MDMA (‘Ecstasy’) e pelo exercício físico." Master's thesis, Universidade de Aveiro, 2003. http://hdl.handle.net/10773/18837.
Повний текст джерелаCom este trabalho procurou-se estudar, no músculo soleus de ratinho, os efeitos da administração da MDMA e da sua associação com o exercício físico. Para isso utilizaram-se 72 ratinhos Charles River CD1, distribuídos ao acaso por quatro grupos experimentais (n=18/grupo), que foram sujeitos à administração intraperitoneal de soro fisiológico e/ou 3,4- metilenodioxometanfetamina (MDMA) na dose de 10 mg/Kg. Destes grupos organizaram-se subgrupos (n=6), dos quais alguns foram submetidos ao exercício físico em tapete rolante, no plano horizontal, durante 90 minutos, a 75% da velocidade máxima dos animais Procedeu-se à avaliação de diferentes parâmetros, metabólico (temperatura subcutânea), bioquímico plasmático (creatina cínase-CK) e bioquímicos musculares (mieloperoxidase–MPO e Nacetil ?-glucosaminidase–NAG), em diferentes momentos de avaliação (0, 24 e 48 horas após a administração intraperitoneal de solução salina e/ou MDMA). Todo o protocolo experimental foi acompanhado pela avaliação morfológica do tecido muscular esquelético à luz da microscopia óptica e electrónica, quantificando-se as fibras lesadas (alteração do padrão estriado, vacuolização sarcoplasmática, necrose segmentar e núcleos em posição central). Neste contexto verificou-se que a CK plasmática apresentava o pico de actividade enzimática imediatamente após o exercício para todos os grupos experimentais. Constatou-se ainda que a MDMA produziu um efeito hipertérmico significativo nos animais, não se verificando qualquer influência do exercício físico. A análise morfológica demonstrou que a acção exercida pela MDMA originou, uma lesão muscular extensa expressa pelo número de fibras lesadas. Averiguou-se ainda que esta droga de abuso causa um infiltrado essencialmente linfocitário, verificando-se o pico às 24 horas após o exercício, sendo progressivamente substituído por neutrófilos e/ou macrófagos, como indiciam os valores da MPO e NAG. Pode-se concluir que a MDMA possui um efeito tóxico sobre as fibras musculares e que se prolongam por mais tempo para o grupo que foi sujeito em simultâneo ao exercício físico, o que pronuncia um fenómeno lesivo mais intenso.
This work presents the in vivo performed study for the evaluation of MDMA’s skeletal muscle toxicity, in an attempt to contribute for the understanding of the possible mechanisms involved in this effect. For this purpose were used 72 Charles River CD-1 mice (30-40g), randomly distributed by 4 groups (n=18 mice/group), and submitted to an i.p. injection of 0,1 mL of sterile saline and 10mg/Kg of 3,4-methylenedioxymethamphetamine (MDMA), using sterile saline as vehicle. Some of these groups were subjected to a treadmill level run at 75% of the maximal speed of these mice, during 90 minutes. Immediately before sacrifice 1 mL of blood was collected from inferior vena cava of all animals to quantify plasma creatine kinase activity as an indirect marker of skeletal muscle injury. Both soleus muscles were completely removed, homogenised, and the supernatant was used to the determination of biochemical parameters: N-acetyl-glucosaminidase and mieloperoxidase at different evaluation moments (0, 24 and 48 hours after injection). Cross sections and longitudinal sections of soleus fibers were morphometrically evaluated using a light microscope for an estimation of the percentage of fibers showing any structural alterations (alterations of the striation pattern, sarcoplasmic vacuolisation, segmental necrosis and central nuclei). Ultrathin sections were examined in a Hitachi H9000-NA electron microscope for a qualitative evaluation of the ultrastructure alterations. It was shown that MDMA produces a toxic effect on muscle fibers, observed by the creatine kinase release 90 minutes after the injection, for all o the experimental groups. It was also verified that MDMA produced a significant hyperthermic effect in the animals. The morphological evaluation demonstrated that MDMA induce an extense muscle damage, exposed by the number of damaged fibers. Furthermore, the MDMA administration results in a lymphocyte infiltrate, 24 hours after exercise, observed in the muscle fibers cross sectional areas. These cells were progressively replaced by neutrophils or macrophages, as demonstrated by the activities of myeloperoxidase and N-acetyl-? - glucosaminidase. It can be concluded that the administration of MDMA produced an extreme muscle injury longer in the animals that were submitted to a simultaneous physical exercise, which denotes a more damaging process.
Hoshi, Rosa. "The neuropharmacological, cognitive and mood effects of ±3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy')." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445586/.
Повний текст джерелаSoar, Kirstie. "Problematic and non-problematic ecstasy (MDMA) usage : cognitive and psychopathological aspects." Thesis, University of East London, 2005. http://roar.uel.ac.uk/3408/.
Повний текст джерелаCirtautas, Alfonsas. "Programavimo kalbų taikymas modelių transformacijoms realizuoti MDA architektūroje." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20050527_103708-63400.
Повний текст джерелаAmbraziūnas, Martas. "Enterprise model based MDA information systems engineering method." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20141111_114310-77387.
Повний текст джерелаŠiuolaikiniai IS inžinerijos metodai yra nuolat vystomi ir tobulinami, tačiau iš esmės jie yra grindžiami empiriniais procesais. Empiriškai išgautų žinių kokybė gali būti nepakankama sėkmingam projekto įgyvendinimui, nes netikslus vartotojo reikalavimų specifikavimas neigiamai įtakoja visus programinės įrangos kūrimo etapus, o tai didina projekto įgyvendinimo riziką. Disertacinis darbas skirtas sukurti IS inžinerijos metodą, kuris įgalintų empiriniais būdais surinktas dalykinės srities žinias patikrinti formalių kriterijų atžvilgiu. Metodui sukurti buvo apjungti žiniomis grindžiamos ir modeliais grindžiamos IS inžinerijos principai. Šiuo tikslu klasikinis MDA procesas buvo papildytas pagrindiniu žiniomis grindžiamos IS inžinerijos komponentu – veiklos modeliu. Darbo metu buvo sukurtas žiniomis grindžiamo MDA metodo dalykinės programos prototipas, kuris iš dalies automatizuoja siūlomo metodo procesą. Žiniomis grindžiamo MDA metodo efektyvumas buvo patikrintas jį taikant eksperimentinio tyrimo atlikimui, kurio metu buvo sukurta pašto siuntų stebėjimo programėlė. Tyrimo metu nustatyta, kad tikslinga taikyti žiniomis grindžiamą MDA metodą PĮ kūrime nes: 1) detaliau dokumentuojami vartotojo reikalavimai (tikrinami formalių kriterijų atžvilgiu); 2) sumažinama loginių trūkių atsiradimo galimybė (tarp programinės įrangos kūrimo dalyvių); 3) daugiaplatforminiuose sprendimuose sumažinamos projekto įgyvendinimo laiko sąnaudos (dėka automatinio kodo generavimo iš patikrintų modelių).
MARIA, BEATRIZ ALVES DE. "MDA BASED APPROACH FOR DEVELOPING MULTI-AGENT SYSTEMS." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2005. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=6593@1.
Повний текст джерелаMulti-agent systems (MAS) differ from non-agent systems because agents are intended to be autonomous units capable of flexible and intelligent actions. For this reason it is proposed in the literature a great number of methodologies frameworks and languages to support the development of these systems. Several methodologies and their tools are come from artificial intelligent community and are focused in a specific agent architecture. This work proposes the use of the Model Driven Architecture (MDA), described by OMG, in the development process of MAS. MDA specifies a structured software development process in modeling stages that supports all system development life cycle. The proposed development process is divided according to the MDA stages. In PIM stage, where platform independent models are specified, we propose the use of MAS-ML modeling language for MAS. In PSM stage, where platform specific models are specified, we propose the use of UML modeling language. The MASML models defined on PIM stage are transformed in UML models at PSM stage, based on an object-oriented framework for implementing MAS. In the last development stage, the application code is generated from UML models. This work details the PIM and PSM stages of the MAS development process and the models transformations to generate source code. To exemplify the applicability of the proposed MAS development process, two different MAS applications were developed based on the process. Finally, a MAS-ML tool is presented. Such tool was developed to support the proposed development process. The tool implements all stages presented in the process, allowing the modeling and implementation of MAS.