Дисертації з теми "MC3D"
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Wei, Linkai. "Development of a new steam explosion model for the MC3D software." Electronic Thesis or Diss., Université de Lorraine, 2023. http://www.theses.fr/2023LORR0097.
The steam explosion is one of the most critical and complex phenomena that may occur during severe accident in a Nuclear Power Plant. The MC3D computer code is recognized as reference for the evaluation of this phenomenon. This explosive phenomenon is analogous to a detonation. The explosion is due to the fragmentation of the molten fuel, the passage of the shock wave and the very fast release of the associated energy. However, the precise mechanisms of the process of pressurization are very uncertain and have been the subject of works carried out under the program RSNR-ICE (2014-2023), which led to an increased understanding of general phenomenology and validated the general principle of MC3D, based on a principle of direct boiling around the surface of the corium fragments via a film boiling mechanism. However, it appears that the fragmentation processes seem, under certain conditions, to be achieved without a significant dispersion of the fragments in the water, which is contrary to what presupposes the current MC3D model. The aim of the thesis is to propose an improved modeling of the explosion for MC3D, combining the current principle of direct boiling and fuel-coolant interaction localized in a small volume around the corium drops and fragments. Following an extensive bibliography of the steam explosion phenomenon, a detailed analysis of the behavior of the current MC3D model is performed, using a simple and ideal test-case. Despite the simplicity of the data set, the analysis can be directly applied to experiments with one-dimensional geometry such as KROTOS. The crucial role of initial and created void is highlighted; It also suggests the first outlines of a new model. The Basilisk software was then used to perform DNS simulations to get details of fragmentation and association heat transfers. Comprehensive analysis about fragmentation regimes, statistics including Sauter Mean Diameter and Probability Density Function of fragment mass/area, the transient Nusselt number and drag coefficient were conducted. At the same time, results for the same test-case using MC3D are compared with that of Basilisk, highlighting the need of modification of MC3D model. Finally, the main lines of a proposed new model are presented and discussed. Those that could be directly validated from the DNS results were implemented in the current MC3D version. This concerns in particular the introduction of a Non-Equilibrium Micro-Interaction (NEMI), The other proposals concerning the behavior of the void may be implemented in the future version (V4) of the code
Castrillon, Escobar Sebastian. "Instabilité et dispersion de jets de corium liquides : analyse des processus physiques et modélisation dans le logiciel MC3D." Thesis, Université de Lorraine, 2016. http://www.theses.fr/2016LORR0102/document.
In the case of a severe accident in a nuclear power plant, the molten core may flow into water and interact with it. The consequences of this fuel-coolant interaction (FCI) for the follow-up of the accident may be numerous so the phenomenon needs to be described accurately, one of them called “steam explosion” can lead to the failure of the nuclear reactor containment. FCI is a complex multiphase interaction involving several physical phenomena. The premixing phase of the interaction consists in the fragmentation and dispersion of corium in the coolant pool. This phase is driven by the fragmentation process which modifies heat transfers (coolant boiling dynamics) and chemical reactions (corium oxidation and hydrogen generation). This thesis brings new elements about the corium jet and droplet breakup with the main goal of improve fragmentation models on the MC3D multiphase code, developed by the IRSN. Our study is based on a multi-scale fragmentation process where the jet fragmentation rate and final droplet dimensions are not coupled themselves. We suppose a fragmentation process resulting from a primary instability (mass transfer within jet and big droplets) depending on the large flow scales and a secondary instability depending on the small flow scales (leading to final droplet breakup). This model has been implemented in MC3D in combination with the MUSIG method recently added to MC3D. In this method, droplets are represented using several classes, each of them with their own droplet diameter, mass and energy fields. Despite new improvements on modeling corium fragmentation, there is still a lack on the comprehension and characterization on the liquid droplet fragmentation, particularly on liquid/liquid configurations. In this thesis, we study in detail droplet breakup using the computational fluid dynamics software GERRIS. As a result, we find a new droplet breakup classification in liquid/liquid configurations, we improve the droplet breakup dynamics comprehension and we analyze the droplet-vortex interaction to determine breakup regime transition
Mankin, Danielle N. "MC3R and MC4R Knockdown via RNA Interference." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/biology_theses/37.
Chen, Kenway. "MCAD - ECAD integration : constraint modeling and propagation /." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26484.
Committee Chair: Schaefer, Dirk; Committee Member: Panchal, Jitesh; Committee Member: Paredis, Chris; Committee Member: Rosen, David; Committee Member: Yoder, Douglas. Part of the SMARTech Electronic Thesis and Dissertation Collection.
Law, Tsz Hong. "The effects of a MCTD in canine epilepsy." Thesis, Royal Veterinary College (University of London), 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.766311.
Dong, Liang. "Novel optical fibre devices based on MCVD method." Thesis, University of Southampton, 1992. https://eprints.soton.ac.uk/404723/.
Wilcox, Adam C. "ECAD to MCAD Interoperability for Automated Enclosure Design." Diss., CLICK HERE for online access, 2008. http://contentdm.lib.byu.edu/ETD/image/etd2690.pdf.
DALI, DALIA. "Alterations of uromodulin biology and FJHN/MCKD syndrome." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3423213.
L’Uromodulina (Tamm-Horsfall protein) è una proteina che si trova normalmente in quantità abbondante nelle urine. Le mutazioni del gene che codifica l’Uromodulina (gene UMOD) sono associate con la Familiar Juvenile Hperuricemic Nefropathy (FJHN) e la Medullary Cystic Kidney Disease tipo 2 (MCKD2), che si manifestano con iperuricemia e gotta, ridotta escrezione frazionaria dell’acido urico, insufficienza renale cronica. L’eta’ di esordio è nell’infanzia per la FJHN, mentre la MCKD2 esordisce attorno ai 30 anni con ridotta concentrazione urinaria, iperuricemia, insufficienza renale cronica e si associa a cisti renali. FJHN/MCKD2 sono malattie autosomiche dominanti, con quadro istologico di nefropatia interstiziale. Alcuni autori le considerano una malattia unica. La maggior parte delle mutazioni di UMOD descritte in letteratura modificano uno dei 48 residui di cisteina. Queste mutazioni alterano la struttura terziaria causando accumulo intracellulare e conseguente disfunzione tubulare. Materiali e metodi: Abbiamo studiato 3 famiglie presentano il fenotipo della sindrome di FJHN/MCKD: nelle due prime famiglie una storia familare con una importante ricorrenza di iperuricemia e IRC, ma nella treza famiglia, nonostante, l'assenza della familiarità per patologia renale, la presenza dell'insufficienza renale e l'iperuricemia, hanno confermato la diagnosi della sindrome di FJHN/MCKD. L’analisi genetica è stata effettuata sulla DNA genoma, e tuuti gli esoni del UMOD gene, e HNF1B gene sono stati sequenziati. Risultati: Nella prima famiglia: l’analisi genetica evidenziava la presenza di due mutazioni missenso di UMOD, mai descritte precedentemente. Quindi il probando è eterozigote composto per due mutazioni: l’una UMODc 392 G>A Trp202Arg ereditata dalla madre affetta anch’essa da FJHN, l’altra UMODc 604 T>C Gly131Asp ereditata dal padre e presente anche nel fratello del probando, ambedue (padre e fratello) tuttavia asintomatici per questa malattia. Nella seconda e terza famiglia, non sono stati identificati mutazioni per UMOD gene, neanche per HNF1B gene. Conclusione: il caso clinico ci permette di acquisire nuove informazioni sulla patologia molecolare di UMOD: - è possibile trovare due UMOD mutazioni in un paziente affetto dalla sindrome FJHN/MCKD. -Sostituzione in residui non cisteinici sono in grado di indurre accumulo intracellulare di uromodulina e conseguentemente la nefropatia. -Varianti aminoacidiche che non causano l’accumulo di uromodulina, non causano la nefropatia ma potrebbero essere associate ad ipertensione, come recentamente evidenziato in altri lavori scientifici. - Le mutazioni del UMOD gene non sono l'unica causa della sindrome FJHN/MCKD.
Spitezki, Henri. "Contribution à l'étude du management stratégique : le modèle MCVD." Paris 1, 1998. http://www.theses.fr/1998PA010012.
In this dissertation, I try to give a better qualitative understanding of the macroeconomic effects of unemployment benefits. The two most important question i ask is the comparison of the positive properties of unemployment insurance and of unemployment assistance, which constitute the second part of the dissertation, and the determination of the global generosity of unemployment benefits, which constitute the third part of the dissertation. The first part propose a survey of the literature. In the first chapter, i focus on models where the probability of being unemployed depends only on individuals' behaviour while in the second chapter, unemployment arises because of imperfect competition in the wage setting. In the two other parts of the dissertation, i use a dynamical wage bargaining model in which search effort does no matter. In chapter 3, i show that the digressiveness of unemployment benefits might increases the unemployment rate. In chapter 4,1 show that indexing unemployment benefits on past wage earned increases the wage pressure and the equilibrium unemployment. Chapter 5 looks at the level of the replacement ratio that maximises different steady-state welfare criterions. The optimal replacement ratio according to unemployed workers is higher than the one according to employed workers, which is itself higher than the one according to the sum of utility of every workers. At last, the replacement ratio that maximises profits is null. The last chapter introduces a voting process on the level of the replacement ratio so as to understand why rational agents supports levels of replacement ratio that leads to a positive level of the unemployment rate. We prove the existence of a negative relation between the unemployment rate and the replacement ratio
Šálková, Michaela. "Sledování obsahu 3-MCPD v ječmeni, sladu a pivu." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2018. http://www.nusl.cz/ntk/nusl-376823.
Griffith, Robert C. "Mobile Cubesat Command and Control (MC3)." Thesis, Monterey, California. Naval Postgraduate School, 2011. http://hdl.handle.net/10945/5591.
The Mobile CubeSat Command and Control (MC3) program will become the ground segment of the Colony II satellite program. The MC3 ground station contains Commercial Off-the-Shelf (COTS) hardware with Government Off-the-Shelf (GOTS) software making it an affordable option for government agencies and universities participating in the Colony II program. Further, the MC3 program provides educational opportunities to students and training to space professionals in satellite communications. This thesis analyzes the MC3 program from the program manager's point of view providing a Concept of Operations (CONOPS) of the program as well as initial analysis of MC3 ground station locations. Also included in this thesis is a future cost analysis of the MC3 program as well as lessons learned from the NPS acquisition process.
Merkle, Sybille Barbara [Verfasser], and Bernward [Akademischer Betreuer] Bisping. "Analytik und technologische Minimierungsansätze von Monochlorpropandiol (MCPD), MCPD-Fettsäureestern und Glycidylestern in frittierten und geräucherten Fischerzeugnissen und Fischölen / Sybille Barbara Merkle ; Betreuer: Bernward Bisping." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://d-nb.info/1181328845/34.
SANTOS, WALLAS HENRIQUE SOUSA DOS. "MCAD SHAPE GRAMMAR: PROCEDURAL MODELING FOR INDUSTRIAL MASSIVE CAD MODELS." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2018. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=34609@1.
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO
Modelos CAD 3D são ferramentas utilizadas na indústria para planejamento e simulações antes da construção ou realização de tarefas. Em muitos casos, como por exemplo na indústria de óleo e gás, esses modelos podem ser massivos, ou seja, possuem informações detalhadas em larga escala no intuito de que sejam fontes de informações precisas. Para obtenção de navegação interativa nesses modelos é necessária uma combinação de hardware e software adequados. Mesmo hoje com GPUs mais modernas, a renderização direta desses modelos não é eficiente, sendo necessárias abordagens clássicas como descarte de objetos não visíveis e LOD antes de enviar os dados à GPU. Logo, para renderização em tempo real de modelos CAD massivos são necessários algoritmos e estruturas de dados escaláveis para processamento da cena de forma eficiente. O trabalho dessa tese propõe o MCAD (Massive Computer-Aided Design) Shape grammar, uma gramática expansiva que gera objetos para criar cenas 3D de modelos massivos de forma procedimental. Nos últimos anos, modelagem procedimental tem ganhado atenção para criar cenas 3D rapidamente utilizando uma representação compacta, que armazena regras de geração ao invés de representação explícita da cena. MCAD Shape grammar explora repetições e padrões presentes em modelos massivos para renderização de cenas, reduzindo o consumo de memória e processando a cena procedimentalmente de forma eficiente. Convertemos modelos reais de refinarias em MCAD Shape grammar e implementamos um renderizador para os mesmos. Os resultados mostraram que esta solução é escalável com alto desempenho, além de ser a primeira vez que modelagem procedimental é utilizada nesse domínio.
3D CAD models are tools used in the industry for planning and simulations before construction or completion of tasks. In many cases, such as in the oil and gas industry, these models can be massive, that is, they have large-scale detailed information in order to be sources of accurate information. Interactive navigation in these models requires a combination of appropriate hardware and software. Even nowadays with modern GPUs, the direct rendering of these models is not efficient, requiring classic approaches such as culling non-visible objects and LOD before sending the data to the GPU. Therefore, for real-time rendering of massive CAD models, we need scalable algorithms and data structures to efficiently process the scene. The work of this thesis proposes MCAD (Massive Computer-Aided Design) Shape grammar, an expansive grammar that procedurally generates objects to create 3D scenes of massive models. In recent years procedural modeling has drawn attention for quickly creating 3D scenes using a compact representation, which stores generation rules rather than explicit representation of the scene. MCAD Shape grammar explores repetitions and patterns present in massive models for rendering scenes, reducing memory footprint and procedurally processing the scene efficiently. We converted real refinery models into MCAD Shape grammar and implemented a renderer for them. Results showed that our solution is scalable with high performance, also it is the first time that procedural modeling is used in this domain.
Enseroth, Timo [Verfasser]. "Konstruktion und Validierung der MCD-Skala zur Erfassung unterschwelliger organischer Psychosyndrome (Minimale Cerebrale Dysfunktion, MCD) im Erwachsenenalter / Timo Enseroth." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2011. http://d-nb.info/1026264200/34.
Ye, Qionghuan. "Strategies to Inhibit the Formation of 3-Monochloropropane Diol During Deep-Fat Frying." Thesis, North Dakota State University, 2020. https://hdl.handle.net/10365/32048.
Adams, Lindsey. "Investigating the role of CTSZ, MC3R and MC4R in host susceptibility of tuberculosis." Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/5474.
Thesis presented in partial fulfillment of the requirements for the degree Master of Science in Medical Biochemistry at the University of Stellenbosch.
Bibliography
ENGLISH ABSTRACT: Tuberculosis (TB) is an infectious disease which has plagued society for thousands of years. Despite public health programs, anti-TB drugs and a vaccine, the absolute numbers of people infected with TB each year continue to rise as populations grow. The high TB-burden areas are also plagued by other debilitating factors including HIV/AIDS infection, poverty and malnutrition. Nutrition has been implicated in TB susceptibility in a number of studies. While most are observational reports made during times of war, famine or natural disaster, multiple studies provide convincing evidence for poor nutritional status increasing the morbidity and mortality of TB. Numerous approaches are currently utilized in TB research, and there has been convincing evidence to support the role of host genetics in TB susceptibility. Based on previous linkage studies and a search of current literature, three genes were selected for this case-control study. Subsequently, variations located in cathepsin Z (CTSZ), melanocortin 3 receptor (MC3R) and melanocortin 4 receptor (MC4R) were genotyped in the South African Coloured (SAC) population to determine the existence of an association with TB disease. CTSZ is a lysosomal cysteine protease expressed in cells of the immune system. Interaction between this 303 amino acid protein and β2 integrin receptors lymphocyte function-associated antigen-1 (LFA-1) and macrophage antigen-1 (MAC-1) leads to altered lymphocyte proliferation. As a result, a single exonic variant in CTSZ, rs34069356, the same identified in a previous linkage study, showed strong evidence for association with TB susceptibility in cases (n = 410) and controls (n = 301) in the SAC population (p< 0.0001). MC3R and MC4R are two of 5 melanocortin receptors. MC3R has been found to be a key regulator in energy expenditure and host metabolism while activation of MC4R leads to a decrease in food intake. Activation of these two receptors is regulated by leptin, a hormone released by adipose tissue. A variant located upstream of the MC3R gene, rs6127698, also showed evidence of disease association with the less frequent allele, T, being under-represented in cases (n = 540) compared to controls (n = 541) (genotypic frequency, p = 0.0039), suggesting a possible resistance phenotype. Functional analysis of this variant revealed an increase in MC3R expression when stimulated with BCG, with individuals homozygous for the T allele exhibiting an even larger upregulation of MC3R expression than individuals homozygous for the G allele, though this difference was not statistically significant. A single haplotype in MC3R was found to be associated with TB susceptibility (p = 0.0008) and this association remained after permutation testing to correct for multiple testing (p = 0.0061) Three variants were selected for genotyping in MC4R and while none of these showed a statistically significant difference between cases (n = 510) and controls (n = 487), this gene should not be ruled out as both MC3R and MC4R have been found to work closely though not redundantly and double knockout experiments result in exacerbated obesity, suggesting that these proteins have a synergistic effect. The results of this study support both a role of host genetics and nutritional status in TB and strongly motivate further research in both of these fields.
AFRIKAANSE OPSOMMING: Tuberkulose (TB) is ‘n aansteeklike siekte wat reeds vir eeue die gesondheid van die publiek bedreig. Ten spyte van publieke gesondheidsprogramme en verskeie anti-TB medikasie middele, groei die aantal van mense wat hiermee ge-infekteer word steeds jaarliks. Dit is veral in areas waar TB steeds groei, waar ook ander neerdrukkende faktore soos HIV/Vigs, armoede en wanvoeding hoogty vier. Na aanleiding van verskeie verslae tydens oorloë, hongersnood en ander natuulike rampe is dit veral duidelik dat swak nutriënt inname morbiditeit en sterftes wat met TB gepaard gaan verhoog. Talle benaderings word tans gebruik in TB-navorsing, Bewyse is oortuigend om die rol van genetika van die gaheer met vatbaarheid vir TB te verbind. Op grond van vorige studies en die huidige literatuur, het ons drie gene gekies vir hierdie pasiënt-kontrole studie. Variante geleë in cathepsin Z (CTSZ), melanocortin 3 receptor (MC3R) en melanocortin 4 receptor (MC4R) is ge-genotipeer in die Suid-Afrikaanse Kleurling bevolking (SAK) (540 gevalle en 540 kontrole) om sodoende die assosiasie met TB te bepaal. CTSZ is ‘n lisosomale sisteïen protease wat uitgedruk word in immuunselle. Interaksie tussen hierdie 303 aminosuur protein en β2 integrin reseptore nl. LFA-1 en MAK-1 bring veranderde limfosiet proliferasie mee. ‘n Enkele eksoniese variant in CTSZ, rs34069356, dieselfde soos ge-identifiseer in ‘n vorige studie, verskaf sterk bewys vir assosiasie met TB vatbaarheid in gevalle (n = 410) en kontrole (n = 301) in die SAK bevolking. MC3R en MC4R is twee van 5 melanokortien reseptore. Daar is gevind dat MC3R 'n sleutelrol speel in die energie regulering van gasheer metabolisme, terwyl die aktivering van MC4R eindelik lei tot 'n afname in voedsel inname. Aktivering van hierdie twee reseptore word gereguleer deur Leptien, 'n hormoon wat vrygestel word deur adipose weefsel, ‘n Variant, stroomop geleë vanaf MC3R, rs6127698, is ook bewys om met TB ge-assosieer te wees, met die T-alleel meer seldsaam in gevalle (n = 540) as in kontroles (n = 541) wat dui op 'n moontlike weerstandsfenotipe. Funksionele analise van hierdie variant onthul 'n toename in MC3R uitdrukking wanneer gestimuleer met BCG, met individue homosigoties vir die T-alleel wat selfs groter opregulation veroorsaak wanneer vergelyk word met individue homosigoties vir die G allele. Hierdie resultaat was egter nie statisties beduidend nie. 'n Enkele haplotiepe in MC3R is ge-assosieer met TB vatbaarheid en die assosiasie is onveranderd nadat ‘n permutasie korreksie aangebring is (p = .0061). Voorts is drie variante gekies vir genotipering in MC4R en ten spyte daarvan dat nie een daarvan 'n statisties beduidende verskil getoon het tussen pasiënte (n = 510) en kontroles (n = 487) nie, behoort hierdie geen nie uitgesluit word nie, Die rede hiervoor is dat beide MC3R en MC4R verskeie kere gevind is om in samewerking ‘n rol te speel om vetsug te voorkom of te vererger. Die resultate van hierdie studie beaam beide 'n rol van gasheer genetika en voedingstatus in TB en motiveer veral verdere navorsing in beide van hierdie vakgebiede.
Yano, Yuzo. "Digitalização de sinais de TV atraves de um sistema MCPD com predição e quantização." [s.n.], 1986. http://repositorio.unicamp.br/jspui/handle/REPOSIP/261037.
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Campinas
Made available in DSpace on 2018-07-17T20:07:02Z (GMT). No. of bitstreams: 1 Yano_Yuzo_D.pdf: 5893095 bytes, checksum: 1bffe7bfb833270e85f22a0e0d4be9be (MD5) Previous issue date: 1986
Resumo: Não informado.
Abstract: Not informed.
Doutorado
Doutor em Engenharia Elétrica
Arvidsson, Ann-Christine. "Framtagningav miljöbedömningsmetod av leverantörer : arbetet utfört hos Parker Hannifin AB MCD." Thesis, University West, Department of Informatics and Mathematics, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-889.
Singer, R. "Matrix induced effects in the MCD spectra of isolated metal atoms." Thesis, University of East Anglia, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374272.
Wu, Haoran. "Multi-Channel Constant Current (MC3) LED Driver for Indoor LED Luminaries." Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/35727.
Master of Science
Wolff, Pamela A. Carleton University Dissertation Chemistry. "Electronic and magnetic hypersensitivity in the MCD spectra of lanthanide complexes." Ottawa, 1990.
Danesfahani, Gholam Reza. "A study in optimising a multicarrier demultiplexer demodulator (MCDD) for on-board processing (OBP) satellites." Thesis, University of Surrey, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309262.
Alcaide, Sarah M. "Mobile CubeSat Command and Control (MC3) 3-meter dish calibration and capabilities." Thesis, Monterey, California: Naval Postgraduate School, 2014. http://hdl.handle.net/10945/42572.
The Mobile CubeSat Command and Control (MC3) architecture is a growing network of ground stations that spans the United States of America. It was designed to support the National Reconnaissance Office’s Experimental CubeSat Program. Each node was originally designed to communicate via UHF and S-band frequencies using Yagi antenna only. The MC3 ground station at the Naval Postgraduate School has recently incorporated a 3-meter S-band dish. This thesis documents the calibration and capabilities of the new S-band dish. It also investigates the possibility of using the antenna outside of its normal operating range. In particular, the idea of using an S-band, 3-meter dish to receive UHF band signals was tested by designing a UHF signal feed optimized for 915 MHz and used to listen to a UHF source deployed on a high altitude balloon at near orbital distances. In addition, this document discusses the integration of a dish system into current and future MC3 ground stations.
Iverson, Ryan. "Measuring Core Outcomes from Metabolic Chart-Abstracted Data for Medium-Chain Acyl-CoA Dehydrogenase (MCAD) Deficiency." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41527.
Irvine, Alan David. "Mutation analysis in human keratin diseases." Thesis, Queen's University Belfast, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268237.
Doube, Michael. "Calcified tissue structure in the distal condyle of the third metacarpal bone in young Thoroughbred horses." Thesis, Queen Mary, University of London, 2007. http://qmro.qmul.ac.uk/xmlui/handle/123456789/28654.
Hualpa, Benavente Flor Patricia. "Componentes principales mediante el método robusto MCD: Matriz de covarianzas de determinante mínimo." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2012. https://hdl.handle.net/20.500.12672/3136.
--- This research addresses the problem of lack of robustness, by replacing the covariance matrix obtained with the classical method for the covariance matrix obtained with the robust MCD method (Todorov and Filzmoser, 2009). The robust method MCD: Minimun Covariance Determinant, involves making estimates for the mean vector and covariance matrix from the selection of a subsample obtained from the resampling of the data set under study, whose main characteristic is that it has the covariance matrix with the minimum determinant. Many times, the statistical analysis in the presence of outliers, by standard methods, can be misleading because of the sensitivity of these methods, which is why the objective of this paper is to present the methodology of the MCD estimators in order to achieve the "robustified covariance matrix" which will be used to perform Principal Component Analysis on data sets with the presence of outliers. We illustrate the methodology of the theory and application, for two sets of data, research results in the Botany (Quinteros, 2010 and Gomez, et. Al., 2008), we analyze the behavior of the Principal Components with the MCD method and we compare it to the classic methodology. It is determined that the principal components obtained by the MCD method allows to find better indicators for data sets with outliers. -- Keywords: Minimum Covariance Determinant, MCD, Principal Components, Robust Estimation, Scatter Matrix.
Tesis
Toriguchi, Kan. "CHOP deficiency attenuates steatohepatitis, fibrosis and carcinogenesis in mice fed an MCD diet." Kyoto University, 2014. http://hdl.handle.net/2433/188659.
Peng, Peijing. "Interaction of alpha-gamma-MSH analogues with MC1, MC3 and MC4 melanocortin receptors." Thesis, University of Bath, 1997. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338413.
Salhany, David Salim. "Performance analysis of a multistage multicarrier demultiplexer/demodulator (M-MCDD) in the presence of interference and quantization error." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0019/MQ47831.pdf.
Baird, Guilherme Barreto. "Um sistema MCPD para transmissão digital de sinais de TV em cores com predição linear a quantização otimizada." [s.n.], 1989. http://repositorio.unicamp.br/jspui/handle/REPOSIP/261698.
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Eletrica
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Mestrado
Mestre em Engenharia Elétrica
Theunissen, Kathrin. "Fotometrische Untersuchungen zur Medium Chain Acyl-CoA Dehydrogenase (MCAD)-Aktivitätsmessung in kleinen Blutvolumina unter Verwendung von Dichlorophenolindophenol (DCPIP)." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:25-opus-52713.
Soares, Flávia Roberta Chaves. "O papel da galalina na modulação da ansiedade experimental mediada pela matéria cinzenta periaquetutal dorsal (MCPD) de ratos." reponame:Repositório Institucional da UFES, 2014. http://repositorio.ufes.br/handle/10/1975.
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FAPES
A galanina (GAL) é um peptídeo composto por 29 aminoácidos que está presente no SNC de inúmeros mamíferos, inclusive do homem. A distribuição da GAL e de seus receptores em estruturas envolvidas com o controle das emoções apontam para um possível papel modulatório desse neuropeptídeo sobre a ansiedade. A Matéria Cinzenta Periaquedutal Dorsal (MCPD) é considerada uma estrutura-chave para a expressão comportamental e autonômica do comportamento defensivo. Entretanto, o papel da GAL nessa estrutura ainda não foi estudado. A MCPD recebe projeções galaninérgicas de outras estruturas, mas não sintetiza o peptídeo em seus corpos celulares. Foram clonados 3 diferentes receptores para a GAL, GALR1 e GALR3, que aumentam o efluxo de K+, e GALR2, que aumenta a concentração intracelular de Ca++. Estudos de imunohistoquímica e hibridização in situ descreveram a presença do GALR1 e do GALR2 na MCPD, embora o GALR1 apareça em maior número. O objetivo do presente estudo foi investigar o envolvimento da GAL sobre a modulação da ansiedade experimental mediada pela MCPD de ratos. Para tanto, foi realizada cirurgia estereotáxica em ratos Wistar adultos para implantação unilateral de uma cânula-guia na MCPD (AP-lambda: 0 mm; L: 2,0 mm; e P: 4,0 mm, 15o), por onde as seguintes drogas foram administradas: GAL (0,1; 0,3; 1,0 e 3,0 nmoles/ 0,2μL), M617 - agonista seletivo GalR1 (0,3; 1,0 e 3,0 nmoles/ 0,2μL) e AR-M1896 – agonista seletivo GalR2 (0,3; 1,0 e 3,0 nmoles/ 0,2μL). Passados 5-7 dias de recuperação, cada animal recebeu a injeção de droga e 20 min. após foi submetido aos testes do LCE, LTE e Vogel. Grupos independentes de animais (n= 5-12) foram usados em cada experimento. A GAL, e os ligantes seletivos M617 e AR-M1896, nas diferentes doses testadas, não alteraram de modo significativo os parâmetros porcentagem de entrada e porcentagem de tempo nos braços abertos (BAs) do LCE. Os resultados mostraram que o tratamento com a GAL (3,0 nmoles) prejudicou a Esquiva 2 de modo significativo, sem alterar a fuga. O tratamento agudo com a GAL não alterou a atividade locomotora verificada no Campo Aberto. E por fim, a GAL (1,0 e 3,0 nmoles) não apresentou diferença para o número de lambidas punidas no Teste do Conflito de Vogel em comparação ao grupo controle. Dessa forma, o efeito tipo-ansiolítico da GAL mediado pela MCPD parece depender do modelo experimental empregado e dos níveis de ansiedade gerados pelo mesmo.
Galanin (GAL) is a 29 amino acids peptide that is present in the CNS of many mammals, including human being. The distribution of GAL and its receptors in emotions control structures involved suggests a possible modulatory role of this neuropeptide on anxiety. The dorsal periaqueductal gray (DPAG) is considered a key structure for behavioral and autonomic expression of defensive behavior. However, the role of GAL in this region has not been studied. The DPAG receives galaninergic projections from other structures, but does not synthesize the peptide on their cell bodies. GAL's actions are mediated by 3 metabotropic receptors, GALR1 and GALR3, which increase K+ efflux, and GALR2, which increases Ca2+ intracellular concentration. Using in situ hybridization technique was described the presence of GALR1 and GalR2 receptors in rat DPAG neurons, but there is GALR1 in greater density. The aim of this study was to investigate the involvement of GAL on the modulation of experimental anxiety by DPAG in rats. Therefore, Wistar rats with a unilateral cannula aimed at the DPAG (AP-lambda: 0 mm; L: 2.0 mm; e P: 4.0 mm, 15o), where the drugs were administered, received the following drugs: GAL (0.1; 0.3; 1.0 e 3.0 nmol/ 0.2μL), M617 – selective agonist GALR1 (0.3; 1.0 e 3.0 nmol/ 0.2μL) e AR-M1896 – selective agonist GALR2 (0.3; 1.0 e 3.0 nmol/ 0.2μL). After 5-7 days of recovery, each animal received an injection of drug and tests were carried-out in the plus-maze, elevated T-maze (ETM) or Vogel Test 20 min later. Each experiment was conducted with separated groups of animals (n=5-12). Tests performed at plus-maze after injection of GAL or selective agonists M617 and AR-M1896 into-DPAG did not change percentage of entries and percentage of time spent in the open arms. The analysis showed that treatment with GAL (3 nmol) significantly impaired Avoidance 2 in the ETM, without change Escape behavior. Acute treatment with GAL did not change locomotion in the Open Field. Finally, GAL (1.0 e 3.0 nmol) did not show difference in the number of punished licks at Conflict Vogel Test in comparison with control group. Thus, the anxiolytic effect of GAL in the DPAG seems to depend on the experimental model of anxiety employee and anxiety level generated by them. Key-words: Galanin. DPAG. Anxiety. T-maze.
Soares, FRC. "O Papel da Galanina na Modulação da Ansiedade Experimental Mediada pela Matéria Cinzenta Periaquedutal Dorsal (mcpd) de Ratos." Universidade Federal do Espírito Santo, 2014. http://repositorio.ufes.br/handle/10/5130.
A galanina (GAL) é um peptídeo composto por 29 aminoácidos que está presente no SNC de inúmeros mamíferos, inclusive do homem. A distribuição da GAL e de seus receptores em estruturas envolvidas com o controle das emoções apontam para um possível papel modulatório desse neuropeptídeo sobre a ansiedade. A Matéria Cinzenta Periaquedutal Dorsal (MCPD) é considerada uma estrutura-chave para a expressão comportamental e autonômica do comportamento defensivo. Entretanto, o papel da GAL nessa estrutura ainda não foi estudado. A MCPD recebe projeções galaninérgicas de outras estruturas, mas não sintetiza o peptídeo em seus corpos celulares. Foram clonados 3 diferentes receptores para a GAL, GALR1 e GALR3, que aumentam o efluxo de K+, e GALR2, que aumenta a concentração intracelular de Ca++. Estudos de imunohistoquímica e hibridização in situ descreveram a presença do GALR1 e do GALR2 na MCPD, embora o GALR1 apareça em maior número. O objetivo do presente estudo foi investigar o envolvimento da GAL sobre a modulação da ansiedade experimental mediada pela MCPD de ratos. Para tanto, foi realizada cirurgia estereotáxica em ratos Wistar adultos para implantação unilateral de uma cânula-guia na MCPD (AP-lambda: 0 mm; L: 2,0 mm; e P: 4,0 mm, 15o), por onde as seguintes drogas foram administradas: GAL (0,1; 0,3; 1,0 e 3,0 nmoles/ 0,2μL), M617 - agonista seletivo GalR1 (0,3; 1,0 e 3,0 nmoles/ 0,2μL) e AR-M1896 agonista seletivo GalR2 (0,3; 1,0 e 3,0 nmoles/ 0,2μL). Passados 5-7 dias de recuperação, cada animal recebeu a injeção de droga e 20 min. após foi submetido aos testes do LCE, LTE e Vogel. Grupos independentes de animais (n= 5-12) foram usados em cada experimento. A GAL, e os ligantes seletivos M617 e AR-M1896, nas diferentes doses testadas, não alteraram de modo significativo os parâmetros porcentagem de entrada e porcentagem de tempo nos braços abertos (BAs) do LCE. Os resultados mostraram que o tratamento com a GAL (3,0 nmoles) prejudicou a Esquiva 2 de modo significativo, sem alterar a fuga. O tratamento agudo com a GAL não alterou a atividade locomotora verificada no Campo Aberto. E por fim, a GAL (1,0 e 3,0 nmoles) não apresentou diferença para o número de lambidas punidas no Teste do Conflito de Vogel em comparação ao grupo controle. Dessa forma, o efeito tipo-ansiolítico da GAL mediado pela MCPD parece depender do modelo experimental empregado e dos níveis de ansiedade gerados pelo mesmo.
Westphal, Anne [Verfasser]. "UV/Vis, MCD and EPR Spectra of Mononuclear Manganese and Molybdenum Complexes / Anne Westphal." Kiel : Universitätsbibliothek Kiel, 2014. http://d-nb.info/1053653530/34.
Warnke, Max Holger [Verfasser]. "Klinische Korrelate von Indikatoren komplexer Teilleistungsstörungen bzw. Minimaler Cerebraler Dysfunktion (MCD) / Max Holger Warnke." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1030382522/34.
Gonzales, de Olarte Efraín. "La Matriz de Capacidades y Desempeños (MCD) y el Algoritmo del Desarrollo Humano (ADH)." Economía, 2012. http://repositorio.pucp.edu.pe/index/handle/123456789/117871.
Dado que el desarrollo humano es un proceso complejo que tiene múltiples componentes ydeterminantes, es necesario tener indicadores multidimensionales tales como la Matriz de Capacidadesy Desempeños (MCD) y el Algoritmo del Desarrollo Humano (ADH).El MCD está compuesto de vectores de capacidades y de desempeños, basado en la idea de Sensobre desempeños refinados. Está basado en un marco conceptual matricial, tanto estático comodinámico. El propósito principal de la construcción del índice es estudiar cómo diferentes conjuntosde capacidades con desempeños pueden producir distintos resultados.El ADH es un índice multidimensional relacionado con el conjunto de bienes y servicios que senecesitan para completar un ciclo de vida. El ADH es un indicador de contexto socioeconómico.Está compuesto de los principales satisfactores o bienes y servicios básicos que se requieren: alimentos,salud, educación, vivienda, seguridad social, empleo decente y sistema de pensiones, quedeben estar disponibles durante todo el ciclo de vida. Este indicador muestra el progreso materialalcanzado por cada país o región, tanto como la organización institucional pública y privada, yel grado de cohesión social.
Moretto, Patricia. "Thromboprophylaxis in Hospitalized Medically Ill Cancer Patients." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30656.
SILOTE, G. P. "Efeitos Comportamentais da Cetamina em Ratos Expostos ao Labirinto em t Elevado: Possível Envolvimento da Via de Sinalização de Bdnf/trkb na Matéria Cinzenta Periaquedutal." Universidade Federal do Espírito Santo, 2016. http://repositorio.ufes.br/handle/10/8110.
A cetamina é um antagonista não competitivo dos receptores glutamatérgicos do tipo N-metil-D-aspartato (NMDA). Estudos pré-clínicos e clínicos têm sugerido que ela apresenta efeito antidepressivo de início rápido e relativamente persistente. O mecanismo de ação envolvido nesse efeito parece ser mais complexo do que o simples bloqueio dos receptores NMDA, envolve a ativação dos receptores α-amino-3-hidroxi-5-metil-4-isoazolepropiônico (AMPA) e da via de sinalização do fator neurotrófico derivado do cérebro (BDNF) e do receptor de tirosina cinase B (TrκB). Diversos fármacos antidepressivos são eficazes no tratamento do transtorno de ansiedade generalizada (TAG) e no transtorno do pânico (TP) somente após tratamento crônico, é possível que a cetamina apresente efeito ansiolítico ou panicolítico de forma rápida e persistente. O labirinto em T elevado (LTE) é um modelo que permite avaliar, no mesmo procedimento, dois tipos de ansiedade: a ansiedade aprendida (esquiva inibitória), relacionada com o Transtorno de Ansiedade Generalizada (TAG), e a ansiedade inata (fuga), relacionada com Transtorno de Pânico (TP). O objetivo do estudo foi investigar os efeitos comportamentais induzidos pela cetamina em ratos expostos ao LTE e o possível envolvimento da via BDNF/ TrκB na MCP (matéria cinzenta periaquedutal) nesses efeitos. Os resultados mostraram que a cetamina de 10 e 30 mg/Kg (doses subanestésicas) administrada de forma aguda não alteraram o comportamento dos ratos no LTE. Já a dose anestésica (80 mg/Kg), prejudicou a fuga 1, o que pode sugerir efeito tipo-panicolítico rápido. Quando a cetamina 10 mg/Kg foi administrada 24 horas antes do teste no LTE, houve facilitação da Fuga 1, o que pode sugerir um efeito tipo-panicogênico tardio. Já a dose anestésica da cetamina administrada 24 horas antes do teste facilitou à esquiva, o que sugere um efeito tipo-ansiogênico tardio, e ao mesmo tempo prejudicou a fuga 1, sugerindo um efeito tipo-panicolítico persistente. E o 5-metil-10,11-dihidroxi-5Hdibenzo(a,d)ciclo-heten-5,10-imina ; 0,05mg/Kg (MK-801; 0,05 mg/Kg) 24 horas antes do teste não alterou o comportamento dos animais. Quando a cetamina foi administrada diretamente na MCPD (matéria cinzenta periaquedutal dorsal) observou-se que apenas a dose mais baixa, de 2µg, facilitou a fuga 1, o que caracteriza um efeito tipo-panicogênico rápido. Além disso, nenhum dos esquemas de administração e doses empregados alteraram a atividade locomotora dos animais no campo aberto. Para investigar o envolvimento da via de sinalização de BDNF/TrκB nos efeitos da cetamina e do MK-801 na ansiedade no LTE, foi realizado a quantificação de TrκB total e fosforilado nos resíduos 706/707 e 515 de tirosina (Y-706/707 e Y-515) da MCP de ratos. A cetamina 80mg/Kg e o MK-801 0,05 mg/Kg administrados agudamente antes da coleta da MCP, não induziram alteração estatisticamente significante na quantidade de pTrκB nos resíduos Y-706/707 e Y-515. Adicionalmente, a cetamina 10 e 80 mg/Kg, administrada aproximadamente 24 horas antes da coleta da MCP, não induziu alteração estatisticamente significante na quantidade de pTrκB no resíduo Y-706/707 e Y-515. Em conclusão, os resultados encontrados mostraram que a cetamina pode ter um efeito muito discreto no pânico, sendo que esse efeito depende tanto da dose quanto do esquema de administração. Ainda, pelo menos o efeito panicogênico da cetamina parece envolver a MCPD
Fridlind, Ann M., Xiaowen Li, Di Wu, Lier-Walqui Marcus van, Andrew S. Ackerman, Wei-Kuo Tao, Greg M. McFarquhar, et al. "Derivation of aerosol profiles for MC3E convection studies and use in simulations of the 20 May squall line case." COPERNICUS GESELLSCHAFT MBH, 2017. http://hdl.handle.net/10150/624334.
Karimova, Natalia Vladimirovna. "Theoretical study of the optical properties of the noble metal nanoparticles: CD and MCD spectroscopy." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/38177.
Department of Chemistry
Christine M. Aikens
Gold and silver particles with dimensions less than a nanometer possess unique characteristics and properties that are different from the properties of the bulk. They demonstrate a non–zero HOMO–LUMO gap that can reach up to 3.0 eV. These differences arise from size quantization effects in the metal core due to the small number of atoms. These nanoparticles have attracted great interest for decades both in fundamental and applied research. Small gold clusters protected by various types of ligands are of interest because ligands allow obtaining gold nanoclusters with given sizes, shapes and properties. Three main families of organic ligands are usually used for stabilization of gold nanoclusters: phosphine ligands, thiolate ligands and DNA. Usually, optical properties of these NPs are studied using optical absorption spectroscopy. Unfortunately, sometimes this type of spectrum is poorly resolved and tends to appear very similar for different complexes. In these cases, circular dichroism (CD) and magnetic circular dichroism (MCD) spectroscopy can be applied. However, the interpretation of experimental CD and MCD spectra is a complicated process. In this thesis, theoretically simulated CD and MCD spectra were combined with optical absorption spectra to study optical activity for octa– and nona– and undecanuclear gold clusters protected by mono– and bidentate phosphine ligands. Additionally, optical properties of bare and DNA protected silver NPs were studied. Theoretical CD spectra were examined to learn more about the origin of chirality in chiral organometallic complexes, and to contribute to the understanding of the difference in chiroptical activity of gold clusters stabilized by different phosphine ligands and DNA–stabilized silver clusters. Furthermore, optical properties of the small centered gold clusters Au₈(PPh₃)₈²⁺ and Au₉(PPh₃)₈³⁺ were examined by optical absorption and MCD spectra using TDDFT. Theoretical MCD spectra were also used to identify the plasmonic behavior of silver nanoparticles. These results showed that CD and MCD spectroscopy yield more detailed information about optical properties and electronic structure of the different chemical systems than optical absorption spectroscopy alone. Theoretical simulation of the CD and MCD spectra together with optical absorption spectra can be used to assist in the understanding of empirically measured CD and MCD and provide useful information about optical properties and electronic structure.
Stroup, Diane. "Investigations of the products of mcrD and mcrC, two genes of the methyl coenzyme M reductase operon from Methanococcus vannielii /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487780865410873.
Oliveira, Sofia Pereira. "Regulamentação global: foco em ésteres de 3-MCPD e ésteres glicidílicos com base no parecer científico da EFSA em 2016." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22485.
O presente trabalho descreve as atividades desenvolvidas durante o estágio curricular efetuado na empresa Dan Cake (Portugal), S.A., no âmbito do mestrado em Biotecnologia Alimentar. Em maio de 2016, o Painel de Contaminantes da Cadeia Alimentar da Autoridade Europeia para a Segurança Alimentar (EFSA) publicou uma opinião científica sobre os riscos para a saúde pública relacionados com a presença do 3-monocloropropano1,2-diol (3-MCPD), os seus ésteres de ácidos gordos e os ésteres glicidílicos (GE) nos alimentos. Estes são considerados genotóxicos e carcinogénicos, isto significa que ao longo do tempo podem danificar o DNA e causar cancro. Posto isto, a dose diária admissível (DDA) para o 3-MCPD e os seus ésteres foi reduzida de 2 μg/kg de peso corporal para 0,8 μg/kg de peso corporal. Um cliente Alemão exige que os produtos para ele vendidos apresentem metade da DDA surgindo, assim, a necessidade de acompanhar a empresa no estudo deste contaminante, para a nova formulação dos produtos, de forma a analisar o que pode ser feito por parte da mesma para mitigar os valores deste contaminante no produto final. Para melhor compreender o contaminante foram realizadas análises ao pão e às tostas da nova formulação das tostas com recurso a um laboratório externo. Foram também analisadas as matérias-primas utilizadas na formulação que condicionam o teor de 3-MCPD, o óleo de palma e o desmoldante, com recurso à técnica de infravermelho. As análises realizadas em laboratório externo permitiram perceber que poderá ocorrer um aumento de 3-MCPD durante o processo de tostagem e que o desmoldante poderá ter influência no teor do contaminante. Já a técnica de FT-IR não parece ser a técnica indicada para analisar este contaminante, contudo forneceu dados importantes a nível nutricional das tostas analisadas. Com os resultados das análises externas foram ainda conseguidos dados interessantes para futuras pesquisas. Além da investigação, o estágio integrou-se, na maior parte do tempo, em atividades desenvolvidas nos Departamentos de Rotulagem, através da prestação de informação aos consumidores sobre géneros alimentícios, e no Departamento de Segurança e Qualidade Alimentar, realização de inspeções mensais às linhas de produção.
The present work describes the activities developed during the curricular internship at the company Dan Cake (Portugal), S.A., within the scope of the Master's Degree in Food Biotechnology. In May 2016 the European Food Safety Authority (EFSA) Panel on Contaminants in the Food Chain published a scientific opinion on the public health risks associated with the presence of 3-monochloropropane-1,2-diol (3-MCPDs), their fatty acid esters and the glycidyl esters (GE) in food. These are considered genotoxic and carcinogenic, this means that over time they can damage the DNA and cause cancer. Thereafter, the allowable daily intake (DDA) for 3-MCPD and its esters was reduced from 2 μg / kg body weight to 0.8 μg / kg body weight. One of the company’s clients demands that the products sold to them present half of the TDI therefore, the need arose to follow the company in a study for this contaminant in order to analyze what could be done by the same to mitigate the values of this contaminant in the final product. To understand the contaminant better, analyzes were carried out on a recipe of sold toasts using analyzes in an external laboratory and analyzes of the raw materials at risk using the FT-IR technique in order to assist the company in the acquisition of knowledge. The analysis carried out in an external laboratory showed that an increase of 3-MCPD may occur during the roasting process and that the release agent may influence the contaminant content. The FT-IR technique does not seem to be the indicated technique to analyze this contaminant; however, it provided important nutritional data of the analyzed toasts. With the results of the external analyzes, interesting data were also obtained for future research. In addition to this investigation. the internship had most of the time the direct contact with activities developed in the Departments of Labeling and Security and Food Quality.
Otey, Jeffrey Martin. "A Contribution to Conveying Quality Criteria in Mechanical CAD Models and Assemblies through Rubrics and Comprehensive Design Intent Quantification." Doctoral thesis, Universitat Politècnica de València, 2018. http://hdl.handle.net/10251/94627.
This research examined the use of assembly rubrics, described how they evolved from parts rubrics, and studied how they affect student self-evaluation. Instructor assessment of students was also evaluated, finding that while the assembly rubrics were partially understood and effectively used by the students, they were more successfully utilized by the instructors. Strategies designed to improve design intent communication in CAD models, in order to enhance their quality, with guidelines targeted to evaluate efficiency, have been addressed with this research. It is apparent that metrics directed toward the instruction of design intent are needed, since design intent transferred through CAD models can be performed at three stages with competing tradeoffs that must be balanced to arrive at the best modeling strategy. Research included the development of a validation approach that reflects that rubrics are valuable devices to expedite consistent design intent communication, and are vital not only for evaluation, but also for the communication of instructor expectations. This research examined how to clearly define qualities of design intent to enable easier CAD assembly assessment. It has been found that there is more inter-rater agreement and correlation between instructors than between instructors and students, for all rubric dimensions. There is strong to moderate correlation between instructors for the dimensions of validity, completeness, conciseness, and clarity, while slight correlation exists for the dimensions of consistency and design intent. Secondly, rubrics can also be described as being either static or dynamic. Static rubrics, existing in paper form only, do not provide immediate feedback to the learner. Dynamic rubrics perform calculations that provide immediate evaluative observations to the user. Besides, they can be independently adapted to specific situations depending on the capability of the user. Electronic rubrics are ideally suited for dynamic rubrics, and permit the use and development of both adaptable and adaptive rubrics, as described next. Thirdly, rubrics need to be adaptable which should make them easily understood and user-friendly, and adaptive (rubric can change itself, depending on the usage pattern). Evaluative rubrics are used when an expert determines the pedagogical progress of a learner, while formative rubrics are employed by the learners themselves, in order to chart their progress and identify scholastic deficiencies that are in need of remediation. Rubrics must be continually refined and improved, in an iterative, collaborative process, until satisfactory agreement is attained, both between raters, but also between raters and learners. Thus, assertions maps were developed, illustrating how the expand-contract strategy adapts the rubrics to CAD trainee progress, while assisting the understanding of the different rubric dimensions. Based on the assembly rubric experiments, it is apparent that the small differences between instructors suggests that the proposed assemblies rubric is sufficiently sophisticated to furnish an unbiased accumulative assessment of student performance. Accordingly, it can be confidently stated that raters can be used interchangeably without sacrificing accuracy. However, the assembly rubric possesses finite efficacy to produce formative self-evaluation of CAD assembly skills for new learners.
Aquesta investigació examinà l'ús de rúbriques de acoblament, descrivint la seua evolució a partir de rúbriques de peces, i estudià cóm afecten a la autoavaluació dels estudiants. També es va valorar la avaluació dels estudiants per els instructors, trobant que, mentre que les rúbriques de acoblament van ser parcialment compreses i fetes servir de manera eficient per els estudiants, van ser usades amb mes èxit per els instructors. En aquesta investigació s'han abordat estrategues dissenyades per a millorar la comunicació de la intenció de disseny en models CAD, creixentat així la seua qualitat, amb directrius dirigides a avaluar la seua eficiència. Es evident que es necessiten mètriques dirigides cap a la instrucció de la intenció de disseny, ja que la intenció de disseny transferida a través de models CAD pot realitzar-se en tres etapes amb criteris contradictoris que deuen ser equilibrats per a arribar a la millor estratègia de modelatge. La investigació ha inclòs el desenvolupament de un mètode de validació que demostra que las rúbriques son dispositius útils per a garantir una comunicació consistent de la intenció de disseny, i son fonamentals no només per a avaluar, però també per a comunicar les expectatives de l'instructor. En aquesta investigació s'examinà com definir clarament les qualitats de la intenció de disseny per a permetre una mes fàcil avaluació de un acoblament CAD. Per a totes les dimensions de la rúbrica, es va trobar mes concordança i correlació entre instructors que no pas entre instructors i estudiants. Existeix una correlació moderada/fort entre els instructors per a les dimensions de la validesa, completesa, concisió i claredat, mentre que existeix una lleugera correlació per a les dimensions de consistència i intenció del disseny. En segon lloc, les rúbriques també poden ser descrites com estàtiques o dinàmiques. Les rúbriques estàtiques, existeixen sòls en paper, no proporcionen retroalimentació immediata a l'educand. Les rúbriques dinàmiques realitzen càlculs que proporcionen observacions de avaluació immediates al usuari. A mes, poden adaptar-se a situacions específiques dependent de la capacitat de l'usuari. Les rúbriques electròniques son ideals per a rúbriques dinàmiques, i permeten l'ús i desenvolupament de rúbriques adaptatives i adaptables, como es descriu a continuació. En tercer lloc, les rúbriques deuen ser adaptables, el que deuria ferles fàcilment comprensibles i fàcils d'usar, i adaptatives. Les rúbriques d'avaluació se usen quant un expert determina el progrés pedagògic de un educand, mentre que les rúbriques formatives son fetes servir per els propis estudiants, per a traçar el seu progrés i identificar les deficiències escolars para a les que necessiten suport. Les rúbriques es deuen refinar i millorar de forma continuada, en un procés iteratiu i col·laboratori, fins que se arriba a un acord satisfactori, tant entre avaluadors como entre avaluadors i alumnes. Por això, es desenvoluparen mapes de assercions que il·lustren el mode en que la estratègia de expansió-contracció adapta les rúbriques al progres del aprenent de CAD, a la vegada que ajuden a comprendre les diferents dimensions de la rúbrica. Basant-se en els experiments amb les rúbriques de acoblaments, es evident que les xicotetes diferencies entre els instructors suggereixen que la rúbrica de acoblaments proposta es lo suficientment sofisticada com per a proporcionar una avaluació acumulativa imparcial del acompliment de l'alumne. En conseqüència, es pot afirmar amb confiança que els avaluadors poden usar-se indistintament sense sacrificar la precisió. No obstant, la rúbrica de acoblaments posseeix una eficàcia finita per a produir una autoavaluació formativa de les habilitats de acoblament CAD per a nous alumnes.
Otey, JM. (2017). A Contribution to Conveying Quality Criteria in Mechanical CAD Models and Assemblies through Rubrics and Comprehensive Design Intent Quantification [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/94627
TESIS
Bsatee, Mohammed N. "The Development of Experimental Setup for Various Magneto-Optical Studies." Ohio University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1438868631.
Tonelotto, Renata Aparecida Cerqueira. "Avaliação da presença do 3-monocloro-1,2-propanediol e glicidol em óleos vegetais comestíveis utilizando GC/MS/MS e seu risco toxicológico." Universidade de São Paulo, 2019. http://www.teses.usp.br/teses/disponiveis/9/9143/tde-18032019-153354/.
Chloropropanols are a known group of contaminants related to food processing. They are formed during the reaction process between lipids and chlorides when submitted to heat treatment and can be found in free or bound form. The 3-monochloro-1,2-propanediol (3-MCPD), is classified by IARC as a possible human carcinogen (group 2B). Glycidol (and its esters), also classified by IARC as a substance likely to be carcinogenic to humans (group 2A), has recently been found in food. The present study aims to evaluate the presence of 3-MCPD and glycidol in edible vegetable oils using gas chromatography with triple quadrupole MS/MS mass detector. The technique applied is recommended by AOCS, guide Cd 29c-13, an indirect analysis, and allows quantification of 3-MCPD and glycidol by building the calibration curves and analysis of reference samples. The method was validated and the detection limit of the contaminant 3-MCPD of 42,4 µg/kg and the quantification limit of 50 µg/kg was established. For Glycidol the detection limit of was 43,5 µg/kg and quantification limit was 50 µg/kg. The results obtained in the calibration and linearity curves demonstrated that the method could express results with good linearity (0 10 mg/kg, r2, = 0.9991). The results obtained in the trueness trials agreed to the criteria of 70 to 120% of recovery, and ± 20% of variation between the results according to what is preconized by SANTE (2017). The method showed to be selective, since no interfering peaks were observed in the retention times of the studied compounds. The tests performed on low, medium and high values demonstrated the robustness and precision of the method, so the validation was considered completed and suitable for the purpose. A total of 368 vegetable oil samples were analyzed (76 samples of canola oil, 48 samples of corn oil, 69 samples of cottonseed oil, 33 samples of palm oil, 10 samples of kern palm oil, 50 samples of palm olein, 30 samples of soybean oil and 51 samples of sunflower oil). The results found in samples for 3-MCPD were within mean values between 203 and 1205 µg/kg. The results found in samples for glycidol were within mean values between 2 to 1198 µg/kg where palm oil presented the highest variation for glycidol from 1600 to 5260 µg/kg. Through the risk assessment for the contaminant 3-MCPD it was possible to detect the values based on exposed worst case scenario and analytical results. The results for cottom oil were 0,044 µg/kg bw, sunflower 0,045 µg/kg bw, canola 0,18 µg/kg bw and palm oil 0,28 µg/kg bw, corn oil 0,0462 µg/kg bw, and for soybean, which is the most consumed oil in Brazil (72%) the value of 0,27 µg/kg bw. These results indicates safe consumption for these oils based in the Theoretical Daily Ingestion - TDI of 2µg/kg bw. The risk assessment for the glycidol based on exposure worst case scenario and analytical results presented for cottom oil the value of 0,061 µg/kg bw, sunflower 0,03 µg/kg bw, canola oil 0,13 µg/kg bw , palm oil 0,57 µg/kg bw, corn oil 0,11 µg/kg bw and for soybean, which is the most consumed in Brazil - 72% the value of 0,27 µg/kg bw. These results indicates safe consumption for these oils based in the TDI of 1000µg/kg bw.
Mooranian, Mahsa. "My Crystal Diary (MCD) : an integrated software application for recording the observations and results of crystallisation experiments." University of Western Australia. School of Electrical, Electronic and Computer Engineering, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0121.
Tuncer, Omer Aykut. "An Evaluation Of The Work Carried Out By The Mediterranean Commission On Sustainable Development." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/2/12605681/index.pdf.
Thongnuch, Sathida [Verfasser]. "An approach to generating high-fidelity models for the virtual commissioning of specialized production machines and cells using MCAD models / Sathida Thongnuch." Hamburg : Helmut-Schmidt-Universität, Bibliothek, 2021. http://d-nb.info/1241977119/34.
Rediger, Anne. "Charakterisierung von Interaktionen G-Protein-gekoppelter Rezeptoren in der hypothalamischen Appetitregulation." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15991.
Food intake is centrally regulated in hypothalamic nuclei where many GPCRs are expressed which are known to be involved in weight regulation.Peripheral hormonal signals activate their corresponding receptors in the arcuate nucleus (ARC) or paraventricular nucleus (PVN) and modulate the orexigenic (appetite-supressing) pathway mediated by stimulation of the melanocortin-4-receptor (MC4R) as well as the anorexigenic (appetite-stimulating) pathway including neuropeptide Y (NPY) and agouti-related protein (AgRP). In a systematic approach we investigated the interaction of a selective number of GPCRs which are co-expressed on the same neurons like MC3R or MC4R and know to play an essential role in hypothalamic weight regulation. Based on the results of a sandwich ELISA and fluorescence resonance energy transfer (FRET) approach we report the interaction of the MC3R and the growth hormone secretagogue receptor (GHSR) which are co-expressed on arcuate NPY/AgRP neurons. It is known that MC3R couple to the Gαs whereas GHSR couple to the Gαq signaling pathway. However, here the co-expression of MC3R and GHSR reveal a profoundly increase cAMP-accumulation after melanocortin (α-, β- and γ-MSH) challenge, that is higher compared to MC3R activation alone. In-depth characterization of the new signaling properties of the MC3R/GHSR heterodimer by different inhibitors revealed the activation of Gαi in the presents of both endogene agonists. The observation of different regulatory pattern after co-stimulation of the heterodimer depending on the endogenouse ligands (α- or γ-MSH) of MC3R reflect complex functional interaction mechanisms between melanocortin and ghrelin receptors within the hypothalamic signaling pathways of weight regulation.