Дисертації з теми "Mar Ligure"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-19 дисертацій для дослідження на тему "Mar Ligure".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте дисертації для різних дисциплін та оформлюйте правильно вашу бібліографію.
CAPONE, ALESSANDRO. "Distribuzione e concentrazione della contaminazione da microplastiche in specie ittiche destinate al consumo umano (Mar Ligure 2018 - 2021)." Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1079656.
Повний текст джерелаMorelli, Danilo. "La cartografia marina: ricerche ed applicazioni orientate ai rischi geologico-ambientali in aree campione." Doctoral thesis, Università degli studi di Trieste, 2008. http://hdl.handle.net/10077/2714.
Повний текст джерелаRIASSUNTO Dati raccolti nell’ambito di progetti di cartografia geologica marina nazionali ed internazionali sono stati utilizzati per ricerche sui rischi geologico-ambientali in alcune aree marine italiane maggiormente critiche dal punto di vista della valutazione dei rischi. Questo rappresenta un campo di applicazione estremamente complesso a causa della varietà dei processi collegati, i quali a loro volta sono controllati da più fattori naturali ed antropici la cui interazione è spesso di difficile valutazione e previsione. Nei settori di margine continentale del Mar Ligure e dell’Arco Calabro (tirrenico e ionico) dati morfo-batimetrici, sismo-stratigrafici, strutturali, e sedimentologici ricavati dalle più moderne tecnologie d’indagine offshore sono stati integrati con altri dati geologici e geofisici pregressi, utilizzando metodologie di visualizzazione, analisi e restituzione tridimensionale digitale di gran dettaglio. Le ricerche sono state condotte in collaborazione con specialisti ed esperti di geologia marina e morfotettonica attiva delle attigue aree emerse, focalizzando l’attenzione sui dissesti gravitativi superficiali e profondi e di loro correlazione con faglie attive recentemente, potenzialmente sismogenetiche o tsunamogeniche. I risultati ottenuti hanno consentito, nelle singole aree, una definizione più approfondita dei caratteri dei vari elementi di geo-hazard ed una più chiara ricostruzione dei meccanismi di interazione tra i vari processi responsabili della loro genesi ed evoluzione. L’analisi dettagliata di alcuni casi maggiormente rappresentativi ha anche confermato la complessità dei tematismi trattati e sottolineato alcune problematiche cruciali, tuttora aperte, su cui concentrare le ricerche future. Il margine continentale del Mar Ligure, tanto nel settore alpino che in quello appenninico, mostra evidenze morfologiche di processi di mobilizzazione gravitativa di ingenti masse sedimentarie. Questi sono maggiormente concentrati nel margine alpino (scarpata di Imperia), associati allo sviluppo di numerosi canyon e alla forte sismicità dell’area, mentre nel settore appenninico, dove l’attività sismica è minore, riguardano principalmente il Canyon di Levante e la Frana di Portofino. Quest’ultima rappresenta un elemento di particolare interesse per i meccanismi di formazione ed il volume dei materiale coinvolti. Nei margini tirrenico ed ionico della Calabria il sollevamento tettonico pleistocenico dell’Arco Calabro (0.8-0.9 mm/anno) è accompagnato da una cospicua attività sismo-tettonica e da frequenti e voluminosi movimenti di massa lungo tutta la scarpata. Tali processi sono concentrati lungo lo sviluppo di articolati sistemi di canyon sia nel Golfo di Squillace che nei settori di Bovalino e Siderno ed anche nel settore tirrenico indagato (tra Palmi e Scilla). Tale focalizzazione dei fenomeni di instabilità è controllata dall’attività sismo-tettonica di lineamenti strutturali di dimensione regionale, paralleli (Faglia di Scilla) allo sviluppo del margine o interpretabili come prosecuzione a mare di sistemi che tagliano trasversalmente tutto l’Arco Calabro. Come appendice al lavoro di ricerca svolto è stato inserito un contributo riguardante l’area dello Stretto di Messina, elaborato per l’occasione del centenario del terremoto di Messina. In tale area una morfodinamica, estremamente rapida, è controllata dai caratteri idrodinamici dello stretto, da faglie attive e movimenti di massa correlati all’attività sismo-tettonica. In tale contesto degli elementi di particolare rischio geo-ambientale sono delle frane che in prossimità di Messina interessano un corpo sedimentario di notevoli dimensioni. Oltre ai contributi sulle conoscenze relativi ai singoli casi è possibile definire alcune conclusioni generali confortate anche da dati di letteratura. I movimenti di massa sottomarini sono estremamente diversificati, e pur presentando alcune analogie rispetto a quelli che si verificano a terra spesso presentano dei meccanismi di innesco e di evoluzione diversi: sono molto più mobili, coinvolgono volumi notevoli di materiale, trasportati in molti casi a notevole velocità e distanza. Un carattere ricorrente nelle aree analizzate è la scarsa presenza di accumuli di frana piede della scarpata rispetto al volume di materiale franato (mancante) lungo il pendio. Una spiegazione plausibile è fornita dai fenomeni che accompagnano lo sviluppo di frane di grosse dimensioni come l’acquaplaning, che agendo come lubrificante al fronte della frana, può determinare l’allontanamento, la disgregazione e dispersione dei materiali (flussi detritici e torbiditici) in aree bacinali molto distanti (100-1000 Km). Tale ipotesi già verificata in altre aree, se confermata per le aree indagate potrebbe, attraverso la datazione dei livelli detritici e torbiditici bacinali correlabili a grandi frane sottomarine, consentire la definizione dei tempi di attivazione e dei tempi di ritorno delle stesse, ed eventualmente il loro rapporto con la sismicità storica regionale. In questo tipo di approccio si deve tener conto dei caratteri sia dell’area sorgente del dissesto che delle zone di accumulo più distali (debriti, torbiditi) al fine di ricostruire un quadro completo dei processi in atto in grado di definire qualitativamente tutti i fattori geologici in gioco (imput sedimentari, sismo-tettonica, presenza di gas, ecc..) e il loro grado di pericolosità. A prescindere dall’interesse scientifico su tali tematiche è fondamentale il loro approfondimento in termini di valutazione di rischio geo-ambientale, considerando le perdite economiche e di vite umane che gli eventi calabro-siciliano e liguri hanno registrato in passato. Inoltre, nonostante la difficoltà di stimare, prevedere o più semplicemente definire la ricorrenza di terremoti di grande entità, l'analisi della sismicità storica e dei tempi medi di ritorno mette in evidenza l'esistenza di ritardi anche importanti per eventi medio-grandi, lungo alcuni dei sistemi di faglie attive sia in Calabria-Sicilia orientale che in Liguria. Gli studi effettuati confermano la convinzione, già espressa da altri ricercatori, che la morfodinamica sottomarina sia più intensa e veloce di quella sub-aerea. Ciò è senz’altro verificato nel presente studio a proposito delle aree in cui l’attività sismo-tettonica, “motore” principale dei processi studiati, supera un certo livello di soglia. Si dimostra comunque che i dissesti dei fondali pellicolari e profondi, limitati ad aree ben definite, possono prodursi anche in zone di sismicità ridotta (Mar Ligure di Levante; Canyon di Levante -Frana di Portofino), ma non per questo di minore importanza in termini di pericolosità. Altra importante conclusione dello studio è che in contesti geodinamici apparentemente molto diversi in base alle conoscenze correnti (margine attivo calabro-ionico e margine passivo ligure) si riscontrano processi morfodinamici sottomarini di paragonabile tipologia ed entità. Ad un esame più attento risulta però che i contesti geodinamici detti, in termini di tipologia di strutture , flusso tettonico, e movimenti verticali non sono poi così diversi , anzi presentano marcate analogie.
XX Ciclo
1965
Lundén, Amanda, and Mikaela Björkegren. ""Man kan ju inte begå brott - då ligger man pyrt till" : Om Polisens organisation och identitetsarbete." Thesis, Uppsala universitet, Sociologiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-215656.
Повний текст джерелаDuring the last few years, there has been a growing interest in the Swedish police. This interest was triggered as the Police organization attempted to dictate what was appropriate when it came to employee behavior outside of work. This essay intends to answer questions regarding how police employees shape their own identities in order to accommodate the requirements of their profession. A qualitative method has been used, using documents and semi structured interviews. A total of eight people have been interviewed. The results indicated that the organization, in some ways, want to regulate their employees. A few hands-on methods exist, they are however too vague to be regarded as present in the day to day work of employees. The police organization does not offer clear guidelines and it is up to the employee to determine their own individual identity. Overall, there is more impact on individuals behavior from colleagues than from Police policy. In summary, we will examine the Swedish police organization with reference to theories about identity work in organizations and in relation to the empirical data.
Poulain, Marine. "Développement de la lignée germinale femelle humaine." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T056/document.
Повний текст джерелаWoman fertility is partially dictated by the set up of the human female germ line. During the last ten years, which saw an increased number of couples consulting for assisted reproductive cares, the hypothesis of an early alteration in reproduction functions has emerged.In the fetal ovary, germ cells enter the path of oogenesis differentiation characterized by meiotic initiation. On this subject, vast majority of the scientific data are obtained from the mouse model, even if differences with human ovarian physiology are widely acknowledged. Therefore it is necessary to extend our knowledge on human ovarian development and identify its perturbations. The objective of my work was to assess a new model to study ovarian growth, studying regulation of meiotic entry and perturbation of germ line differentiation.We sat up a new xenograft model of early human fetal ovaries, when very early meiotic germ cells appear. Organ growth and germ cells differentiation were comparable with in vivo observations. Using this model with an RNA-interference strategy, we inhibited the expression of an oogonia germ cell gene, DMRTA2. This inhibition conducted to a significantly reduced number of germ cells gene that initiated meiosis and DMRTA2 seemed to be required for mitotic-meiotic transition. In another hand, we identified, in the ovary, the expression of germ cells markers described as specifically male in rodent (PLZF, DNMT3L, FGF9, NANOS2 ou CYP26B1). The expression of these markers in the human ovary could explain the observation of mitotic germ cells in late fetal ovaries (30 wpf).In parallel, we tested germ cells sensibility to a synthetic glucocorticoid, dexamethasone, administrated during pregnancy in some justified pathologies. We observed an increased expression of PLZF that could explain the decreased number of germ cells observed in treated ovaries.In conclusion, we identified a new gene expressed in human fetal ovaries, potentially involved in the meiotic entry, and we extended our knowledge to characterized human germ line development. However, many points have to be clarified, as the possible competence of late mitotic germ cells to form oocytes
Chifflet, Marina. "Interprétation par modélisation des processus physiques et biologiques observés à courte échelle de temps sur la colonne d'eau : Application à la mer Ligure en Mai 1995 (Campagne Dynaproc)." Aix-Marseille 2, 2000. http://www.theses.fr/2000AIX22064.
Повний текст джерелаJohansson, Linnea. "Vilka potentiella behandlingsalternativ finns det mot bakteriella infektionssjukdomar som ligger i fas 2-3 studier eller som man bedriver forskning på?" Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-74368.
Повний текст джерелаResistens mot antibiotika har blivit ett globalt världsproblem. Effekten av antibiotika påverkas av de resistenta bakterierna och detta leder till att infektioner blivit svårare att behandla. Detta ger belastning på sjukvården och leder till ökad dödlighet. I världen dör ca 700 000 människor till följd av antibiotikaresistensen och år 2050 beräknas dödsfallen stigit till 10 miljoner per år p.g.a. att det saknas effektiva behandlingsmetoder mot de multiresistenta bakterierna. För att behandla bakteriella infektioner krävs nya föreningar riktade mot bakteriella patogener samt nya tillvägagångsätt för att stoppa denna kris. Inom detta område är framgången låg och även om kliniska försök med antimikrobiella medel är säkra och effektiva, dröjer det flera år innan de är tillgängliga för klinisk användning. Nya strategier inom antibiotikafrågor innefattar nya läkemedelsmål, nya leveransmetoder till läkemedelsmålet och nya läkemedelskombinationer. Syftet med denna studie var att undersöka vilka behandlingsalternativ som finns tillgängliga mot infektionssjukdomar som ligger i fas 2-3 studier, eller som man bedriver forskning på. Arbetet är en litteraturstudie och de vetenskapliga artiklarna är hämtade från databasen Pubmed. I detta arbete har fem studier analyserats. Studie I visar att föreningarna som framställts och riktades mot den nya fickan på DNA-gyras avbröts p.g.a. toxicitet. I resterande studier (II, VI och V) visade att nanopartiklar är ett potentiellt alternativ för att avdöda bakterier. Studie III visar att celler som behandlats med silver hade annan membranpermeabilitet, destabiliserade peptidoglykanlagret och ökad produktion av hydroxylradikaler. Mer forskning och studier krävs för att undersöka riskerna med att administrera nanopartiklar samt verifiera resultaten i denna litteraturstudie och framförallt krävs det mer forskning kring nya potentiella antimikrobiella medel i allmänhet.
Salles, Jean-Paul. "La Ligue communiste révolutionnaire et ses militant(e)s (1968-1981) : étude d'une organisation et d'un milieu militant : contribution à l'histoire de l'extrême gauche en France dans l'après mai 1968." Paris 1, 2004. http://www.theses.fr/2004PA010607.
Повний текст джерелаPradier, Stéphanie. "Caractéristiques de l'écoulement et des précipitations observés durant MAP : une analyse par radar et simulation numérique." Toulouse 3, 2002. http://www.theses.fr/2002TOU30149.
Повний текст джерелаLeufroy, Axelle. "Spéciation de l’arsenic dans les produits de la pêche par couplage HPLC/ICP-MS. Estimation de sa bioaccessibilité en ligne et applications à d'autres éléments traces métalliques d'intérêt." Thesis, Paris, AgroParisTech, 2012. http://www.theses.fr/2012AGPT0030/document.
Повний текст джерелаArsenic is an element present in all compartments of the environment, and seafood constitutes a major source of exposure to arsenic through human consumption. Although there is currently no legislation on arsenic in food in France, government agencies generally assess the safety of food items based solely on the total concentration of the element, without taking into account its different species or their bioaccessibility. Therefore, the development of speciation analysis methods is particularly relevant in the context of risk assessment. The first part of this thesis focuses on the properties of arsenic, its occurrence in the different compartments of the environment and its toxicity, and a literature review of existing analytical methods to study the speciation of arsenic in food matrices, especially seafood products (extraction and separation / detection). Different approaches for evaluating its bioaccessibility and that of other trace metals of interest are also presented.The second part of this work concerns the validation of a speciation analysis method for major arsenic species in seafood (As (III), MA, DMA, As (V), AsB, TMAO, AsC) by coupling ion exchange chromatography (IEC) with inductively coupled plasma mass spectrometry (ICP-MS) after microwave-assisted extraction (MAE). Evaluation of the analytical performance of the method, internal and external quality controls in place and applications of the method, particularly occurrence data of arsenic species in seafood most consumed by the French population are presented and discussed. In the third part, the maximum bioaccessibility of arsenic and other elements of interest is assessed using a continuous leaching method (involving the real-time measurement by ICP-MS of the fraction released by the different artificial digestive fluids). By coupling this leaching method with the above validated speciation analysis method, the bioaccessibility of different arsenic species is also assessed
Pradier, Stephanie. "Caractéristiques de l'écoulement et des précipitations observés durant MAP: une analyse par radar et simulation numérique." Phd thesis, Université Paul Sabatier - Toulouse III, 2002. http://tel.archives-ouvertes.fr/tel-00090330.
Повний текст джерелаLes travaux de recherche effectués durant cette thèse sont basés sur l'analyse de plusieurs d'entre elles, ceci au moyen de données de radars Doppler sole et aéroportés, et du modèle numérique méso-échelle non-hydrostatique Méso-NH. Ces travaux visent à établir le scénario et les processus fondamentaux qui ont mené à leur occurrence. Différents types d'évènements pluvieux ont été étudiés : 2 cas de précipitations convectives, le premier à fort cumul de pluie dans la région du Lac Majeur (ouest des Alpes, POI 2B), et un autre sur la région du Frioul (est des Alpes, POI 5) ; puis des conditions pour lesquelles les précipitations se sont révélées plus modérées sur la région du Lac Majeur (POIs 4, 8, 9 et 15) permettant d'étudier un autre mécanisme lié au relief ou non : le processus de blocage.
Sur ces 6 cas d'étude, le facteur dominant responsable du cumul de pluie au sol est le facteur durée : la persistance des précipitations associée au ralentissement du système dépressionnaire au niveau des Alpes mène aux plus forts cumuls. Ceux-ci ont été enregistrés pour les POIs 2B et 8, soit des évènements convectif et stratiforme respectivement. Dans le cas de la POI 2B, c'est un système quasi-stationnaire d'altitude qui est responsable du ralentissement, alors que pour la POI 8 il s'agit de la nature stable du flux incident sur les flancs alpins, et par la suite de son blocage au niveau du relief. Les POIs 4 et 15, caractérisées également par la stabilité du flux d'alimentation des précipitations, illustrent des acs pour lesquels l'arrivée du front froid associé au système dépressionnaire, et par conséquent d'un flux post-frontal antagoniste au flux d'alimentation, est responsable du déplacement des cellules précipitantes. La POI5 est une situation caractérisant le passage rapide du front froid, et l'évolution d'une ligne de cellules convectives associée.
L'effet du relief a été mis en évidence, dans les épisodes pluvieux stratiforme et convectif. Dans tous les cas, ce dernier contribue à renforcer/déclencher les précipitations. Il est responsable de la déviation vers l'ouest des flux incidents stables. L'impact de l'orographie de petite échelle a également été démontré à l'aide de tests numériques, en particulier les irrégularités du relief de l'ordre du kilomètre ont joué un rôle important dans la progression du système précipitant de la POI 5.
Smida-Rezgui, Sophia. "Analyse du signal calcique des MAP kinases et de l'expression des intégrines dans la régulation de l'apoptose induite par l'EGF dans la lignée cellulaire tumorale humaine A431." Aix-Marseille 2, 2000. http://theses.univ-amu.fr.lama.univ-amu.fr/2000AIX20671.pdf.
Повний текст джерелаLundgren, Vendela, and Wall Ronja Lund. ""VÅRA FÖRSTÅR JU INTE RIKTIGT, EFTERSOM DE ÄR LITE, LIGGER LÅGT I SIN UTVECKLING OM MAN SÄGER SÅ" : En kvalitativ studie om delaktighet och digitalisering på gruppbostäder utifrån personalens perspektiv." Thesis, Mälardalens högskola, Akademin för hälsa, vård och välfärd, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-54883.
Повний текст джерелаThis study’s purpose is to examine staff in group homes’ perceptions of digitalisation for people with disabilities. The progress of digitalisation can't be ignored, yet in group homes it has not been fully established which can affect the possibilities for participation on equal terms for the residents as the remaining population. Seeking to understand digitalisation in group homes and and the effects of digitalisation for the target group, increases the understanding of a current subject for social work and the target group itself. From a qualitative research approach with an abductive method, six semistructured interviews are implemented with staff in group homes to answer the purpose and questions in this study. The results is analysed from a thematic approach based on labeling theory, empowerment and recognition. Digitalisation varies on staffs’ attitudes on disability andresidents in group homes assigned attributes and characteristics, organisation support and staff commitment. Based on norms, staff in group homes can have a certain view on the use of digitalisation which then can affect empowerment and recognition for the target group. If digitalisation is not adapted it can lead to a digital exclusion for people with disabilities.
Tena, Guillaume. "Caractérisation d'activités protéines kinases dans les cellules de tabac (lignée BY-2) : étude de l'effet de l'auxine lors de la reprise de l'activité mitotique et implication de pH cytoplasmique dans l'activation des MAP kinase." Montpellier 2, 1998. http://www.theses.fr/1998MON20096.
Повний текст джерелаLeufroy, Axelle. "Spéciation de l'arsenic dans les produits de la pêche par couplage HPLC/ICP-MS. Estimation de sa bioaccessibilité en ligne et applications à d'autres éléments traces métalliques d'intérêt." Phd thesis, AgroParisTech, 2012. http://pastel.archives-ouvertes.fr/pastel-00770330.
Повний текст джерелаBenammar, Fettouma. "Les écritures algériennes a l'orée du nouveau millenaire : textes et contextes, réécritures et mutations." Thesis, Avignon, 2018. http://www.theses.fr/2018AVIG1187.
Повний текст джерелаInheriting simultaneously from the scriptural tradition of the fathers, from the rupture provoked by the contemporary literature of the 1990s, from its urgency and its obsolescence as well as the advent of the new millennium, the Algerian writings unveiled by the authors of this corpus are marked by concern about the birth of the New Man. Indeed, although inscribed in its episteme, this literature tends to renew itself and to affirm its singularity. If, for Abdellatif Laâbi, all his generation of writers « descend from the mantle of Nedjma », emerging authors can legitimately extend the tribute by declaring themselves, still today, lulled by the chants of the Poet, breast-fed by La Repudiation, warned of high treacheries by Le Muezzin, awakened to the cry of Fis de la haine, acknowledging the widening of their horizons to the poetic dimension of Qui se souvient de la mer. And finally legitimized in the territory of languages, due to being besieged, in turn, by the voice of Assia Djebar and the polyphony of Ces Voix qui m’assiègent. Nevertheless, in answer to the question « Whither literature? » we approach its future by delivering a « temperature chart » by means of the trajectories it seems to take. The paradox of « becoming » lies in its oscillation between past and future, which makes it possible to escape the shackles of the present. It is on the myth that change is strengthened. Straddling the trajectory is both sailing towards possible « futures » and summoning safe bases. Happy Andalusia is the irrefutable guarantee of the feasibility and the illustration of this one-time occurrence can be renewed, as soon as conditions of its emergence are reproduced, by the writing of a « healing text » to manage the trauma and escort the individual towards resilience as well as new experiences of happiness. The New Man is to be reinvented. This is the ambition that the texts of the corpus have helped us to distinguish, whilst sometimes puzzling over its tracks and the contours
André, Aurélie. "Études des modifications de la réponse apoptotique induites par le virus de l'hépatite C dans des foies normaux et infectés et dans la lignée cellulaire HuH7 contenant ou non un réplicon sous-génomique du virus." Thèse, 2004. http://hdl.handle.net/1866/15062.
Повний текст джерелаMathien, Simon. "Identification des composantes du système ubiquitine-protéasome régulant la stabilité de la MAPK atypique ERK3." Thèse, 2016. http://hdl.handle.net/1866/19315.
Повний текст джерелаThériault, Catherine. "L’utilisation des services infirmiers de première ligne pour des raisons de santé mentale par des personnes souffrant de dépression et l’impact sur les besoins non comblés en fonction du sexe." Thèse, 2017. http://hdl.handle.net/1866/20081.
Повний текст джерелаMashtalir, Nazar. "Regulation of BAP1 tumor suppressor complex by post-translational modifications." Thèse, 2014. http://hdl.handle.net/1866/12772.
Повний текст джерелаBAP1 is a nuclear deubiquitinating enzyme (DUB) that acts as a transcription regulator and a DUB of nucleosomal histone H2AK119. In the recent years, it has become clear that BAP1 is a major tumor suppressor, inactivated in a plethora of hereditary and sporadic human malignancies. Although, we now accumulated a significant body of knowledge in respect to the occurrence, penetrance and impact of BAP1 disruption in cancer, its mechanism of action and regulation remained poorly defined. This work is dedicated to the biochemical and functional characterization of the BAP1 multiprotein complex and presents one of the first cases regarding its regulation by post-translational modifications. First, we defined the initial composition of the BAP1 complex and its main interacting components. Second, we specifically focused on two aspects of BAP1 regulation. We described the cross regulation between the two major components of the complex namely HCF-1 and OGT. We found that HCF-1 is important for the maintenance of the cellular levels of OGT. OGT, in turn, is required for the proper maturation of HCF-1 by promoting O-GlcNAcylation-mediated limited proteolysis of its precursor. Third, we discovered an intricate regulatory mechanism of BAP1 mediated by the atypical ubiquitin ligase UBE2O. UBE2O multi-monoubiquitinates BAP1 on its NLS and promotes its exclusion from the nucleus. Importantly, our work emphasises the role of the autocatalytic activity of both enzymes namely the auto-deubiquitination activity of BAP1, required for the maintenance of nuclear BAP1 and the auto-ubiquitination of UBE2O implicated in its nucleocytoplasmic transport. Significantly, we found that auto-deubiquitination of BAP1 is disrupted by cancer-associated mutations, indicating the involvement of this process in tumor suppression.