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Статті в журналах з теми "MAPSE"

Автор: Grafiati

Опубліковано: 11 березня 2023

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1

Qureshi, Azmat Ehsan, Najeeb Ullah, and Farid Ahmed Chaudhary. "MITRAL ANNULAR PLANE SYSTOLIC EXCURSION (MAPSE)." Professional Medical Journal 25, no. 11 (November 10, 2018): 1622–26. http://dx.doi.org/10.29309/tpmj/18.4552.

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Background and Objectives: Assessment of left ventricle function is the singlemost common indication for transthoracic echocardiogram. Out of different indicators of LVfunction, ejection fraction is the most validated one. MAPSE has promised recently to be a reliableand easily obtainable indicator for LV function even in inexperienced hands but its value in caseof left ventricle hypertrophy (LVH) is questionable. Study Design: Cross-sectional comparativestudy. Setting: Rehmatul-lil-Alameen Institute of Cardiology, Lahore. Period: January 2015and March 2015. Methods: 100 consecutive patients presenting for echocardiography atRehmatul-lil-Alameen Institute of Cardiology, Lahore. Patients were divided into two groups onthe basis of presence of left ventricle hypertrophy (LVMI >115 g/m2 in males and > 95 g/m2in females) and further subdivided according to LVEF into those with preserved (EF>55%) anddepressed EF (EF<55%). EF was calculated by visual quantification (eyeballing). MAPSE wasmeasured using M-mode at all four mitral annular sites-medial, lateral, anterior and posteriorand values averaged. Results: Among 100 patients; 66(66%) were without LVH while 34(34%)were having LVH. Without LVH group had 43 (65%) patients with preserved LVEF (EF>55%)while 23 (35%) had depressed LVEF (EF>55%). In LVH group 22 (64.7%) had preservedLVEF while 12 (35.3%) had depressed LVEF. Mean EF (%), without LVH and preserved LVEF(61.6±3.6), LVH with preserved LVEF (61.9±3.6). Mean EF (%); without LVH and depressedLVEF (41.1±6.4), LVH with depressed LVEF (42.9±5.4), p=0.663. Mean MAPSE score (mm);without LVH with preserved LVEF (13.2±1.7), LVH with preserved LVEF (10.6±0.9), p<0.001.Mean MAPSE score (mm); without LVH and depressed LVEF (9.17±0.9), LVH with depressedLVEF (7.4±1.5), p=0.002. Mann Whitney U test was applied to compare the MAPSE score ofgroups and it showed statistically significant difference in MAPSE score of patients with andwithout left ventricle hypertrophy with values much lower in the presence of LVH. Conclusion:Statistically significant difference exists in values of MAPSE in patients with and without leftventricle hypertrophy irrespective of LV function.

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2

Kim, Seung-Hyun, Michael Behnes, Michele Natale, Julia Hoffmann, Nadine Reckord, Ursula Hoffmann, Johannes Budjan, et al. "Galectin-3 Reflects Mitral Annular Plane Systolic Excursion Being Assessed by Cardiovascular Magnetic Resonance Imaging." Disease Markers 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/7402784.

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Background. This study investigates whether serum levels of galectin-3 may reflect impaired mitral annular plane systolic excursion (MAPSE) in patients undergoing cardiac magnetic resonance imaging (cMRI).Methods. Patients undergoing cMRI during routine clinical care were included prospectively within an all-comers design. Blood samples for biomarker measurements were collected within 24 hours following cMRI. Statistical analyses were performed in all patients and in three subgroups according to MAPSE (MAPSE I: ≥11 mm, MAPSE II: ≥8 mm–<11 mm, and MAPSE III: <8 mm). Patients with right ventricular dysfunction (<50%) were excluded.Results. 84 patients were included in the study. Median LVEF was 59% (IQR 51–64%). Galectin-3 correlated significantly with NT-proBNP (r=0.42,p=0.0001). Galectin-3 increased significantly according to the different stages of impaired MAPSE (p=0.006) and was able to discriminate both patients with impaired MAPSE <11 mm (area under the curve (AUC) = 0.645,p=0.024) and <8 mm (AUC = 0.733,p=0.003). Combining galectin-3 with NT-proBNP improved discrimination of MAPSE <8 mm (AUC 0.803,p=0.0001). In multivariable logistic regression models galectin-3 was still associated with impaired MAPSE (MAPSE < 11 mm: odds ratio (OR) = 3.53,p=0.018; MAPSE < 8 mm: OR = 3.18,p=0.06).Conclusions. Galectin-3 reflects MAPSE being assessed by cardiac MRI.

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3

Alatic, Jan, David Suran, Damijan Vokac, and Franjo Husam Naji. "Mitral Annular Plane Systolic Excursion (MAPSE) as a Predictor of Atrial Fibrillation Recurrence in Patients after Pulmonary Vein Isolation." Cardiology Research and Practice 2022 (September 27, 2022): 1–5. http://dx.doi.org/10.1155/2022/2746304.

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Introduction. Catheter ablation (CA) with pulmonary vein isolation (PVI) has become widely used in the past years for the treatment of atrial fibrillation (AF). Mitral annular plane systolic excursion (MAPSE) is the parameter that measures left ventricular longitudinal function, and it appears to be a good early marker of LV dysfunction. It is practically independent of poor image quality. The aim of our study was to analyse the role of echocardiographic variables, especially MAPSE in predicting the outcome of CA in patients with AF. Materials and Methods. We prospectively included 40 patients with paroxysmal and persistent AF that were referred for CA. All patients underwent radiofrequency CA with PVI. Standard transthoracic two-dimensional echocardiography was conducted one day after CA. Demographic data and the patients’ characteristics were noted. The endpoint of our study was to estimate the AF recurrence rate diagnosed by ECG within 6 months of the follow-up period. Results. 40 patients, mainly male (67.5%) with an average age of 61.43 ± 8.96 years were included in our study. The majority of patients had paroxysmal AF prior to ablation (77.5%). The AF recurrence rate was 20% after 6 months of follow-up. Lateral MAPSE in the AF-free group was greater than those who relapsed (1.57 ± 0.24 vs. 1.31 ± 0.25; p = 0.012 ). Patients who remained AF-free after a 6-month follow-up period had a significantly smaller left ventricular volume index (LAVI) than those who relapsed (34.29 ± 6.91 ml/m2 vs. 42.90 ± 8.43 ml/m2; p = 0.05 ). We found a significant reverse relationship between LAVI and MAPSE ( p = 0.020 ). Conclusion. MAPSE and LAVI present risk factors for AF recurrence, specifically reduced MAPSE and larger LAVI, are related to AF recurrence after CA. In the future, MAPSE could play a significant role when predicting the CA outcome in patients with AF.

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4

Rodríguez, M. "P06.09: Performance of TAPSE, MAPSE and TAPSE/MAPSE values in normal fetuses throughout gestation and in newborns by M-mode echocardiography." Ultrasound in Obstetrics & Gynecology 50 (September 2017): 172. http://dx.doi.org/10.1002/uog.18055.

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5

Peixoto, Alberto Borges, Nathalie Jeanne Bravo-valenzuela, Wellington P. Martins, Gabriele Tonni, Rosiane Mattar, Antonio Fernandes Moron, David Baptista Pares, and Edward Araujo Júnior. "Reference ranges for the fetal mitral, tricuspid, and interventricular septum annular plane systolic excursions (mitral annular plane systolic excursion, tricuspid annular plane systolic excursion, and septum annular plane systolic excursion) between 20 and 36 + 6 weeks of gestation." Journal of Perinatal Medicine 48, no. 6 (July 28, 2020): 601–8. http://dx.doi.org/10.1515/jpm-2020-0002.

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AbstractObjectivesThis study aimed to establish reference ranges for fetal mitral, tricuspid, and interventricular septum annular plane systolic excursions (MAPSE, TAPSE, and SAPSE) in normal pregnant women between 20 and 36 + 6 weeks of gestation.MethodsThis prospective and cross-sectional study included 360 low-risk singleton pregnancies between 20 and 36 + 6 weeks of gestation. MAPSE, TAPSE, and SAPSE were measured by M-mode in real time in an apical or basal four-chamber view through placing the cursor at the atrioventricular junction, marked by the valve rings at the tricuspid, mitral, and basal septum, respectively. A regression analysis was done to determine the appropriate polynomial equation model for both measurements and standard deviation (SD) values in relation to gestational age (GA). The intra- and inter-observer reproducibility was evaluated using the concordance correlation coefficient (CCC) and limits of agreement (LoA).ResultsThere was a significant positive correlation between MAPSE (r=0.705, p<0.0001), TAPSE (r=0.804, p<0.0001), and SAPSE (r=0.690, p<0.0001) and GA. The mean of each parameter ranged as follows: 2.87–5.56 mm, MAPSE; 3.98–8.07 mm, TAPSE; and 2.34–4.21 mm, SAPSE. Poor/moderate intra- and inter-observer reliability (CCC between 0.70 and 0.90) and poor/moderate agreement of all the tested parameters were evaluated (LoA between 10 and 50%).ConclusionsReference values were established for the fetal MAPSE, TAPSE, and SAPSE between 20 and 36 + 6 weeks of gestation in low-risk pregnant women. These parameters showed poor/moderate reproducibility.

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6

Paun, Nicolae, Ioan Tiberiu Nanea, Camelia Nicolae, Alice Munteanu, Florentina Cristina Plesa, Magdalena Diaconu, Alina Bisoc, et al. "The Significance of Ventricular Interdependence in Patients with Right Ventricular Hypertrophy and Normal Left Ventricular Function." Revista de Chimie 70, no. 10 (November 15, 2019): 3689–93. http://dx.doi.org/10.37358/rc.19.10.7625.

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The aim of the study is to quantify ventricular interactions by comparing tissue and spectral systolic echocardiographic parameters to allow the early identification of ventricular dysfunction. Clinical, paraclinical, electrocardiographic and echocardiographic evaluations were performed. Right ventricular hypertrophy was diagnosed in the M mode subcostal echocardiographic section. RV hypertrophy was defined by a right ventricular free wall thickness of ] 5 mm in diastole. We assessed the following RV and LV tissue and spectral systolic indices: apical systolic excursion of the lateral mitral ring (MAPSE), apical systolic excursion of the lateral tricuspid ring (TAPSE), left (Svs) and right (Svd) ventricular tissue systolic velocities, and RV and LV ejection times. We calculated the following to assess systolic ventricular interdependence: MAPSE/TAPSE, the normal value of which was considered as 0.66 � 0.14, and Svs/Svd, the normal value of which was considered as 0.76 � 0.21. The study group was compared to a control group with the same clinical features but without ventricular hypertrophy. Twenty-one patients were included in the study: 13 men (62%) and eight women (38%) with a mean age of 56 � 3.8 years. We compared the values between the study group and control group, with the following results: TAPSE = 20.4 � 0.9 vs. 24.1 � 0.76 and MAPSE/TAPSE = 0.74 � 0.06 vs. 0.75 � 0.04. MAPSE was comparable between the groups. Svs was comparable between the groups (0.09 � 0.01 vs. 0.12 � 0.02), whereas Svd was different between the groups (0.11 � 0.03 vs 0.16 � 0.03). Svs/Svd was 0.81 � 0.05 in the study group and 0.75 � 0.08 in the control group. LV ejection time was comparable between the two groups (299.8 � 23.6 ms vs. 303.3 � 28 ms), whereas, RV ejection time differed between the groups (275 � 17 ms vs. 245.5 � 28.5). Changes in TAPSE and MAPSE/TAPSE, in addition to Svd and Svs/Svd, are related to right ventricular dysfunction and suggest pathological changes in the interdependence mechanism of the ventricles in patients with RV hypertrophy. In addition, RV free wall thickness was strongly correlated with ventricular interdependence parameters, with the exception of MAPSE. Assessing these parameters and proportions in clinical practice will facilitate the early detection and appropriate treatment of right ventricular dysfunction.

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7

Saputra, Bagus Made Indrata, Ida Bagus Rangga Wibhuti, Luh Oliva Saraswati Suastika, and Ni Made Ayu Wulan Sari. "The comparison of mitral annular plane systolic excursion (MAPSE) and mitral annular systolic velocity (Sm) in determining subclinical left ventricular systolic dysfunction in patients with type 2 diabetes mellitus." Indonesia Journal of Biomedical Science 16, no. 2 (October 27, 2022): 70–77. http://dx.doi.org/10.15562/ijbs.v16i2.414.

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Background: Type 2 diabetes mellitus (T2DM) is an independent factor in increasing the risk of heart failure in the absence of coronary heart disease and hypertension. Global longitudinal strain (GLS) as the gold standard in determining subclinical left ventricular (LV) systolic dysfunction is not available on all echocardiographic tools and requires good-quality images. Mitral annular plane systolic excursion (MAPSE) and mitral annular peak systolic velocity (Sm) are simpler, faster, and widely available method that can determine left ventricular systolic dysfunction regardless of image quality. Methods: This study involved 72 asymptomatic T2DM patients, divided into two groups, patients with subclinical left ventricular systolic dysfunction (GLS >-18%) and normal systolic function (GLS ≤-18%). GLS was obtained from the mean of 18 left ventricular segments on the apical 4-chamber, 3-chamber and 2-chamber images. MAPSE was obtained on the septal and lateral sides of the mitral annulus using M-mode on apical 4-chamber view, while Sm was obtained using tissue doppler imaging (TDI). Results: The study included 72 asymptomatic T2DM patients, 34 samples (47.2%) were found with subclinical LV systolic dysfunction. According to receiver operating characteristic (ROC) curve analysis, lateral TDI Sm had the highest area under the curve (AUC), it was 0.85, followed by average TDI Sm was 0.83 and average MAPSE was 0.81. The cut-off value of average TDI Sm <7.425 cm/s had the best sensitivity and specificity, 82.4% and 81.6%, while cut-off value of average MAPSE <13.4 mm had sensitivity of 76.5% and specificity of 73.7%. Conclusion: TDI Sm had better accuracy than MAPSE in determining subclinical LV systolic dysfunction in T2DM patients. However, both of them can be used as alternative diagnostic methods of GLS.

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8

Støylen, Asbjørn, Håvard Dalen, and Harald Edvard Molmen. "Left ventricular longitudinal shortening: relation to stroke volume and ejection fraction in ageing, blood pressure, body size and gender in the HUNT3 study." Open Heart 7, no. 2 (September 2020): e001243. http://dx.doi.org/10.1136/openhrt-2020-001243.

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BackgroundAims of this cross-sectional study were to assess: the relative contribution of left ventricular (LV) systolic long-axis shortening (mean mitral annular plane systolic excursion, MAPSE) to stroke volume (SV), the mechanisms for preserved ejection fraction (EF) despite reduced MAPSE, the age dependency of myocardial volume and myocardial systolic compression.MethodsLinear dimensions and longitudinal and cross-sectional M-modes were acquired in 1266 individuals without history of heart disease, diabetes or known hypertension from the third wave of the Nord-Trøndelag Health Study. Measurements were entered into a half-ellipsoid LV model for volume calculations, and volumes were related to age, body size (body surface area, BSA), sex and blood pressure (BP).ResultsMean BP and proportion with hypertensive values increased with increasing age. MAPSE contributed to 75% of SV, with no relation to age or BSA as both MAPSE and SV decreased with increasing age. LV end-diastolic volume (LVEDV) and SV increased with BSA and decreased with higher age; EF was not related to age or BSA. Myocardial volume increased with higher age and BSA, with an additional gender dependency. The association of age with myocardial volume was not significant when corrected for BP, while both systolic and diastolic BP were significant associated with myocardial volume. Myocardial compression was less than 3%.ConclusionsMAPSE contributes approximately 75% and short axis shortening 25% to SV. Both decline with age, but their percentage contributions to SV are unchanged. EF is preserved by the simultaneous decrease in LVEDV and SV. Myocardial volume is positively associated with age, but this is only related to higher BP, which may have implications for BP treatment in ageing. The myocardium is near incompressible.

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9

Karthik, N., G. Gnanavelu, N. Swaminathan, and S. Venkatesan. "Mitral annular plane excursion (MAPSE) correlation with ejection fraction in cardiovascular disease." Indian Heart Journal 69 (November 2017): S80. http://dx.doi.org/10.1016/j.ihj.2017.09.088.

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10

Muhrbeck, Josephine, Elif Gunyeli, Eva Andersson, Mahbubul Alam, Viveka Frykman, and Johanna Sjoblom. "Does stress echocardiography add incremental value to baseline ejection fraction for the early identification of candidates for implantable defibrillators?" Open Heart 6, no. 2 (July 2019): e001053. http://dx.doi.org/10.1136/openhrt-2019-001053.

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ObjectiveA reduction in left ventricular ejection fraction (EF) remains the strongest indicator of increased risk of sudden cardiac death after an acute myocardial infarction (AMI). Guidelines recommend that patients with an EF ≤35%, 6–12 weeks after AMI should be considered for implantable cardioverter defibrillator (ICD) therapy. Stress echocardiography is a safe method to detect viability in a stunned myocardium. The purpose of this study was to investigate if stress echocardiography early after AMI could identify ICD candidates before discharge.MethodsNinety-six patients with EF ≤40% early after AMI were prospectively included in a cohort study, and investigated by baseline and stress echocardiography before discharge. Follow-up echocardiography was performed after 3 months. EF, mitral annular plane systolic excursion (MAPSE) and peak systolic velocity (PSV) were determined for each examination.ResultsThere were 80 (83%) patients who completed the baseline, stress and follow-up echocardiography. Among them there were 32 (40%) patients who met the ICD criteria of EF ≤35% at 3 months. For these patients, EF, MAPSE and PSV were significantly lower than for those patients who recovered. The area under the receiver operating characteristic curve (AUC) was 85% (95% CI 0.74 to 0.94) for baseline EF to predict non-recovery. None of the other variables had a higher AUC.ConclusionPatients who met the ICD criteria of EF ≤35% at 3 months after myocardial infarction had lower EF, MAPSE and PSV on baseline and stress echocardiograph before discharge. Stress echocardiography did not add additional value in predicting non-recovery.

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11

Bakalli, Aurora. "Relationship of Mitral Annular Plane Systolic Excursion (MAPSE) to Left Ventricular Thrombus Formation." Cardiology and Angiology: An International Journal 2, no. 4 (January 10, 2014): 238–46. http://dx.doi.org/10.9734/ca/2014/10716.

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12

Borde, Deepak, S. Joshi, B. Asegaonkar, P. Apsingekar, S. More, and A. Deodhar. "MAPSE – a simple, reliable parameter of LV systolic function in patients undergoing OPCABG." Journal of Cardiothoracic and Vascular Anesthesia 32 (August 2018): S39—S40. http://dx.doi.org/10.1053/j.jvca.2018.08.088.

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13

Issa, Ziad, Nasser Moiduddin, Ziad Rafic Al Bulbul, and Giovanni Di Salvo. "27. New echocardiogram index alternatives to MAPSE and TAPSE z-scores in children." Journal of the Saudi Heart Association 27, no. 4 (October 2015): 310. http://dx.doi.org/10.1016/j.jsha.2015.05.208.

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14

Puricelli, Filippo, Sabiha Gati, Winston Banya, Piers E. F. Daubeney, Dudley J. Pennell, Inga Voges, and Sylvia Krupickova. "Normal values of MAPSE and TAPSE in the paediatric population established by cardiovascular magnetic resonance." International Journal of Cardiovascular Imaging 38, no. 2 (September 28, 2021): 407–9. http://dx.doi.org/10.1007/s10554-021-02415-9.

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15

Syvolap, V. V., and V. A. Lysenko. "Is there the phenotype of chronic heart failure with “intermediate” left ventricular ejection fraction? Additional echocardiographic criteria for left ventricular systolic dysfunction in patients with chronic heart failure of ischemic origin with ejection fraction in the “gray area”." Zaporozhye Medical Journal 23, no. 3 (June 7, 2021): 322–30. http://dx.doi.org/10.14739/2310-1210.2021.3.224710.

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Patients with chronic heart failure (CHF) with left ventricular ejection fraction (LV EF) in the range of 40–55 % form a separate group with “intermediate” or “moderately reduced” LV EF. Since there are a number of additional criteria in echocardiography other than EF for determining LV systolic function (TEI, MAPSE, systolic velocity of the fibrous ring of the mitral valve (S’), E/e’, dP/dt mitral regurgitation, etc.), their use may be helpful in the final identification of systolic dysfunction in CHF patients with LV EF within the “gray area”. The aim of the work – to find out the possibility of using ultrasound parameters of LV systolic function as additional diagnostic criteria for systolic dysfunction and to develop an algorithm for its diagnosis in CHF patients with LV EF within the “gray zone” (40–55 %). Materials and methods. The study included 79 patients (men – n = 49; women – n = 30) with CHF of ischemic origin with LV EF from 40 % to 55 % (main group) who were divided into two subgroups: the first subgroup (n = 40) – patients with LV EF within the “gray area 45–55 %”, the second subgroup (n = 39) – patients with LV EF less than 45 %. The comparison group – 90 patients with coronary heart disease without signs of CHF (men – n = 40, 44.5 %; women – n = 50, 55.5 %). The patient groups were age-, sex-, height-, weight-, body surface area-matched. Doppler echocardiographic examination was performed on the device Esaote MyLab Eight (Italy). Results. According to our results, 90 % (71/79) of CHF patients with reduced LV EF had mitral regurgitation. Additional examination of the systolic index dP/dT of less than 1200 mm Hg/s on the flow of mitral regurgitation allowed to classify CHF patients from the “gray area” (LV EF 40–55 %) to the CHF phenotype with reduced LV EF, and that was almost half of patients – 50.6 % (40/79). Cut off points were established for Myocardial Performance Index TEI of the LV >0.56 r. u., the right ventricle >0.51 r. u., decrease in systolic dP/dT ≤1000 mm Hg/s, systolic velocity of the medial (S med ≤7 cm/s) and the lateral (S lat ≤7 cm/s) fibrous ring of the mitral valve, the amplitude of the medial (MAPSE med ≤11.7 mm) and the lateral (MAPSE lat ≤11.1 mm) fibrous ring of the mitral valve. Conclusions. The cohort of CHF patients with “intermediate” LV EF is a heterogeneous group, which includes patients according to one formal criterion – LV EF in the range of 40–55 %. LV EF is a surrogate marker, insufficient for the final determination of the CHF phenotype. Additional criteria for systolic dysfunction include ventricular TEI, dP/dT mitral regurgitation, systolic velocity (S), and amplitude (MAPSE) of the medial and lateral fibrous ring of the mitral valve. In the presence of two or more additional ultrasound criteria for systolic LV dysfunction, CHF patients with LV EF within 40–55 % should be considered as patients with reduced LV EF.

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Barçın, Cem, Murat Çelik, Uygar Çağdaş Yüksel, Hasan Kutsi Kabul, Serdar Fırtına, Barış Buğan, Emre Yalçınkaya, et al. "OP-114 Mitral Annular Plane Systolic Excursion (MAPSE) Might be Associated with Exercise Capacity in Healthy Subjects." American Journal of Cardiology 115 (March 2015): S50—S51. http://dx.doi.org/10.1016/j.amjcard.2015.01.265.

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Ibrahimi, Pranvera. "Global dyssynchrony correlates with compromised left ventricular filling and stroke volume but not with ejection fraction or QRS duration in HFpEF." International Cardiovascular Forum Journal 1, no. 3 (March 30, 2015): 147. http://dx.doi.org/10.17987/icfj.v1i3.40.

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Background and Aim: Mechanical global left ventricular (LV) dyssynchrony reflected as prolonged total isovolumic time<br />(t-IVT) has been introduced as a potential mechanism behind compromised stroke volume in heart failure (HF). It has also<br />been shown to be superior to other markers of dyssynchrony in predicting response to cardiac resynchronization therapy<br />(CRT), but its application in HF with preserved ejection fraction (HFpEF) remains unknown. The aim of this study was to<br />assess the role of t-IVT in explaining symptoms in HFpEF.<br />Methods: In 55 symptomatic HFpEF patients (age 60±9 years, NYHA class II-IV; LV EF ≥45%) and 24 age and gender<br />matched controls, a complete Doppler echocardiographic study was performed including mitral annulus peak systolic<br />excursion (MAPSE) and myocardial velocities as well as LV filling, outflow tract velocity time integral (VTI) and stroke volume<br />measurements. Global LV dyssynchrony was assessed by t-IVT [in s/min; calculated as: 60 - (total ejection time + total filling<br />time)], Tei index (t-IVT/ejection time) and pre-ejection time difference between LV and RV.<br />Results: Patients had reduced lateral and septal MAPSE (p=0.009 and p=0.01, respectively) lower lateral and septal s’<br />(p=0.002 and p=0.04, respectively) and e’ (p<0.001, for both) velocities and higher E/e’ ratio (p=0.01) compared to controls.<br />They also had longer t-IVT (p<0.001), higher Tei index (p=0.04), but similar pre-ejection time difference and LVEF to controls.<br />T-IVT correlated with LV filling time (r=0.44, p<0.001), stroke volume (r=-0.41; p=0.002), MAPSE (lateral: r=-0.36, p=0.007 and<br />septal: r=-0.31; p=0.02), but not with LV mass index, LVEF, E/e’ ratio or QRS duration.<br />Conclusion: Patients with HFpEF have exaggerated global mechanical dyssynchrony shown by prolonged t-IVT, compared<br />with healthy age and gender matched controls. The relationship between t-IVT, LV filling and stroke volume suggests an<br />association, more important than with ejection fraction or electrical dyssynchrony. These results support the importance of<br />the individualistic approach for optimum HFpEF patient management.

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18

Tripathi, Ashutosh Prasad, Jayanti Venkata Balasubramaniyan, and J. S. Sathyanaryana Murthy. "Mitral annular plane systolic excursion (MAPSE) as a simple index for assessing left ventricular function: An observational study." Indian Heart Journal 73 (December 2021): S71. http://dx.doi.org/10.1016/j.ihj.2021.11.141.

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Tripathi, Ashutosh Prasad, Jayanti Venkata Balasubramaniyan, and J. S. Satyanarayana Murthy. "Mitral annular plane systolic excursion (MAPSE) as a simple index for assessing left ventricular function: An observational study." Indian Heart Journal 73 (December 2021): S4. http://dx.doi.org/10.1016/j.ihj.2021.11.011.

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20

Tempe, Deepak K. "A Quick and Simple Method to Assess Reliably the Left Ventricular Function With TEE: Is MAPSE the Answer?" Journal of Cardiothoracic and Vascular Anesthesia 33, no. 5 (May 2019): 1340–42. http://dx.doi.org/10.1053/j.jvca.2018.11.045.

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Pérez Cruz, M., M. Fernández, J. Sabria, M. Gómez Roig, A. Vela, and J. Lailla. "OP22.06: Systolic dysfunction in intrauterine growth restriction fetuses with abnormal uterine artery Doppler evaluated by TAPSE and MAPSE." Ultrasound in Obstetrics & Gynecology 40, S1 (September 2012): 121. http://dx.doi.org/10.1002/uog.11601.

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Pérez Cruz, M., M. Fernández, J. Sabria, S. Ferrero, and J. Lailla. "OP22.07: Evaluation of right and left heart performance in small-for-gestational-age fetuses with TAPSE and MAPSE." Ultrasound in Obstetrics & Gynecology 40, S1 (September 2012): 121. http://dx.doi.org/10.1002/uog.11602.

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Agha, Hala M., Mahmoud A. Othman, Sonia El-Saiedi, Fatma El Zahrae Hassan, Heba Taher, Amal El-Sisi, Rodina Sobhy, and Antoine AbdelMassih. "Early onset left ventricular remodeling in juvenile systemic lupus erythematosus; Insight from 3-dimensional speckle tracking echocardiography." Lupus 30, no. 13 (November 2021): 2114–23. http://dx.doi.org/10.1177/09612033211051302.

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Background Early diagnosis and treatment of myocardial affection in patients with systemic lupus erythematosus (SLE) are crucial. Objectives To evaluate the ventricular systolic function in juvenile-onset systemic lupus erythematosus (j-SLE) patients by 3-D speckle tracking echocardiography (3D-STE) and to determine the predictors of left ventricular (LV) dysfunction if present. Methods Twenty-six SLE patients without heart failure and 21 healthy controls were studied by standard echocardiogram and 3D-STE. Conventional parameters included LV ejection fraction (EF), fractional shortening (FS), and mitral annular plane systolic excursion (MAPSE). Global LV strain (GLS) and global area strain (GAS) were obtained by 3D-STE. Medical records, including diagnosis criteria, duration of disease, and SLE disease activity index (SLEDAI) were evaluated. Results The mean age was similar in patients and controls 11.42 vs 11.48 years p = 0.93. The mean duration of the disease was 1.87 ± 1.02 years and SLEDAI ranged from 0 to 9. By conventional and tissue Doppler imaging echocardiography, only MAPSE was significantly lower in SLE patients compared to controls (14.56 vs 18.46 mm, p < 0.001). By 3D speckle tracking echocardiography, GLS and GAS were significantly reduced in SLE patients compared to controls (−15.07 vs −19.9.4%, −34.6% vs −39.7%, respectively, p < 0.001). Multiple linear regression and ROC analyses indicated that the SLEDAI score was the only predictive factor for the left ventricular remodeling. Conclusions These results indicate that early subclinical LV dysfunction occur in jSLE patients even with normal EF and SLE disease activity might be a potential driver for LV deformation.

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Riesenkampff, Eugénie, Lena Mengelkamp, Matthias Mueller, Siegfried Kropf, Hashim Abdul-Khaliq, Samir Sarikouch, Philipp Beerbaum, et al. "Integrated analysis of atrioventricular interactions in tetralogy of Fallot." American Journal of Physiology-Heart and Circulatory Physiology 299, no. 2 (August 2010): H364—H371. http://dx.doi.org/10.1152/ajpheart.00264.2010.

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The atria play an important role in cardiac performance. We evaluated their function and the atrioventricular interaction in operated patients with tetralogy of Fallot (TOF). Twenty patients who had undergone surgical repair of TOF and seven controls were investigated. Patients had residual pulmonary but no major tricuspid valve insufficiency. Atrial and ventricular strain rates were obtained by echocardiographic speckle tracking. Cine MRI-derived volumetric analysis provided atrial and ventricular time volume and time volume change curves yielding emptying and filling parameters. In addition, at the atrial level, reservoir, conduit and pump function, and cyclic volume change were calculated. At the atrioventricular valve level, tricuspid and mitral annular plane systolic excursion (TAPSE and MAPSE, respectively) were measured by two-dimensional echocardiography. In the patients compared with controls, right ventricular end-diastolic volumes were increased and biventricular ejection fraction was decreased (all P < 0.05). Biventricular measures of early diastolic ventricular filling were at control levels, but in late diastole, right ventricular filling parameters and strain rates were decreased ( P < 0.001). The maximal right atrial size was slightly but not significantly diminished, but cyclic volume change was significantly reduced ( P < 0.0001). Pump and reservoir function were decreased ( P < 0.05), and conduit function was elevated ( P < 0.001). The left atrium showed reduced reservoir function and cyclic volume change ( P < 0.05). TAPSE and MAPSE were also decreased ( P < 0.05). There were statistically significant interdependencies between RV ejection fraction, TAPSE, and right atrial filling and emptying parameters (all P < 0.05). In TOF patients, moderate systolic and diastolic right ventricular dysfunction is associated with clearly impaired right atrial function. The left atrium is affected to a lesser extent.

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Ortiz, Javier U., Fatima Crispi, Ryo Yamamoto, Narcis Masoller, Monica Cruz-Lemini, Olga Gómez, Mar Bennasar, et al. "Longitudinal annular displacement by M-mode (MAPSE and TAPSE) in twin-to-twin transfusion syndrome before and after laser surgery." Prenatal Diagnosis 35, no. 12 (September 13, 2015): 1197–201. http://dx.doi.org/10.1002/pd.4671.

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Avnet, H., S. Yagel, S. M. Cohen, G. Beirne, and A. W. Welsh. "OP02.03: Evaluating fetal tricuspid and mitral annular plane systolic excursion (TAPSE and MAPSE) using spatiotemporal image correlation (STIC) M-mode." Ultrasound in Obstetrics & Gynecology 46 (September 2015): 57. http://dx.doi.org/10.1002/uog.15116.

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Ginting, Masta N., Refli Hasan, Andika Sitepu, Harris Hasan, Andre P. Ketaren, and Cut A. Andra. "Mitral Annular Plane Systolic Excursion (MAPSE) as a Predictor of Major Adverse Cardiac Events in Patients with ST Elevation Myocardial Infarction." International Journal of PharmTech Research 11, no. 3 (2018): 235–41. http://dx.doi.org/10.20902/ijptr.2018.11305.

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Mądry, Wojciech, Maciej Aleksander Karolczak, and Marcin Myszkowski. "Critical appraisal of MAPSE and TAPSE usefulness in the postoperative assessment of ventricular contractile function after congenital heart defect surgery in infants." Journal of Ultrasonography 19, no. 76 (April 3, 2019): 9–16. http://dx.doi.org/10.15557/jou.2019.0002.

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Borde, Deepak, Balaji Asegaonkar, and Joshi Shreedhar. "CORRELATION OF MITRAL ANNULAR PLANE SYSTOLIC EXCURSION (MAPSE) WITH LEFT VENTRICULAR GLOBAL LONGITUDINAL STRAIN (GLS) IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS SURGERY." Journal of Cardiothoracic and Vascular Anesthesia 35 (October 2021): S7—S8. http://dx.doi.org/10.1053/j.jvca.2021.08.052.

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Terada, Tomomasa, Kazuhiro Mori, Miki Inoue, and Hayabuchi Yasunobu. "Mitral annular plane systolic excursion/left ventricular length (MAPSE/L) as a simple index for assessing left ventricular longitudinal function in children." Echocardiography 33, no. 11 (August 22, 2016): 1703–9. http://dx.doi.org/10.1111/echo.13325.

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Balachandran, Isabel C., Jason Matos, Benedikt Heidinger, Donya Mohebali, Stephanie Feldman, Ian McCormick, Diane Litmanovich, Warren J. Manning, and Brett Carroll. "INCORPORATION OF MITRAL ANNULAR PLANE SYSTOLIC EXCURSION (MAPSE) AND TRICUSPID ANNULAR PLANE SYSTOLIC EXCURSION (TAPSE) FOR RISK STRATIFICATION OF ACUTE PULMONARY EMBOLISM." Journal of the American College of Cardiology 73, no. 9 (March 2019): 1516. http://dx.doi.org/10.1016/s0735-1097(19)32122-9.

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Vasilcu, Teodor Flaviu, Andrei Drugescu, Mihai Roca, Razvan Platon, Radu Gavril, Mădălina Zota, Iris Bararu, Irina Gavril, and Florin Mitu. "The Importance of Echocardiography Assessment in Coronary Patients Subject to Cardiovascular Recovery Programs." Internal Medicine 18, no. 5 (October 1, 2021): 7–13. http://dx.doi.org/10.2478/inmed-2021-0178.

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Abstract Cardiovascular diseases cause approximately one-third of deaths worldwide and an increasing number of individuals with non-fatal ischemic heart disease live with chronic disabilities and impaired quality of life. Cardiac rehabilitation is designed to limit the physiological and psychological effects of cardiac illness, reduce the risk for sudden death or re-infarction, control cardiac symptoms and enhance the psychosocial and vocational status of selected patients. The study group included a group of 78 patients who had a coronary event no more than 3 months ago and who are included in cardio-vascular recovery programs. The patients were echocardiographic evaluated at the first admission and later at 6 months. The evolution of the patients was a favorable one, being objectified an increase of both the ejection fraction of the left ventricle, as well as an improvement of MAPSE and TAPSE.

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Lee-Tannock, Alison, Karen Hay, Alex Gooi, and Sailesh Kumar. "Longitudinal assessment of ventricular strain, tricuspid and mitral annular plane systolic excursion (TAPSE and MAPSE) in fetuses from pregnancies complicated by diabetes mellitus." European Journal of Obstetrics & Gynecology and Reproductive Biology 256 (January 2021): 364–71. http://dx.doi.org/10.1016/j.ejogrb.2020.11.057.

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Aiwuyo, H. O., E. Umuerri, F. Igben, E. Onuwaje, O. Festus, and A. I. Mike. "PO013 Using Mitral Annular Plane Systolic Excursion (MAPSE) and Tissue Doppler Imaging Systolic Velocity (TDI S’) as Surrogates of Left Ventricular Ejection Function." Global Heart 13, no. 4 (December 2018): 391. http://dx.doi.org/10.1016/j.gheart.2018.09.055.

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Gomaa, Mohamed, Maher El-Amir, Heba El-Abedin, Gomaa Abdel-Razik, and Eman Ezzat. "The Diagnostic and Prognostic Value of Mitral Annular Plane Systolic Excursion (MAPSE) as an Echocardiographic Indicator of Myocardial Dysfunction in Sepsis and Septic Shock." Asian Journal of Medicine and Health 7, no. 2 (January 10, 2017): 1–10. http://dx.doi.org/10.9734/ajmah/2017/36145.

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Koestenberger, Martin, Bert Nagel, William Ravekes, Andreas Gamillscheg, Corinna Binder, Alexander Avian, Jasmin Pansy, Gerhard Cvirn, and Berndt Urlesberger. "Longitudinal Systolic Left Ventricular Function in Preterm and Term Neonates: Reference Values of the Mitral Annular Plane Systolic Excursion (MAPSE) and Calculation of z-Scores." Pediatric Cardiology 36, no. 1 (July 31, 2014): 20–26. http://dx.doi.org/10.1007/s00246-014-0959-6.

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Hensel, Kai O., Markus Roskopf, Lucia Wilke, and Andreas Heusch. "Intraobserver and interobserver reproducibility of M-mode and B-mode acquired mitral annular plane systolic excursion (MAPSE) and its dependency on echocardiographic image quality in children." PLOS ONE 13, no. 5 (May 10, 2018): e0196614. http://dx.doi.org/10.1371/journal.pone.0196614.

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Ortiz, J. U., F. Crispi, R. Yamamoto, O. Gómez, M. Bennasar, N. Masoller, S. M. Lobmaier, E. Eixarch, J. Martínez, and E. Gratacós. "OP10.07: Longitudinal annular displacement by M-mode (MAPSE/TAPSE) is abnormal in both recipient and donor in twin-twin transfusion syndrome before and after laser surgery." Ultrasound in Obstetrics & Gynecology 44, S1 (September 2014): 92. http://dx.doi.org/10.1002/uog.13732.

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Menci, Daniele, Francesca Maria Righini, Matteo Cameli, Matteo Lisi, Susanna Benincasa, Marta Focardi, and Sergio Mondillo. "Acute Effects of an Energy Drink on Myocardial Function Assessed by Conventional Echo-Doppler Analysis and by Speckle Tracking Echocardiography on Young Healthy Subjects." Journal of Amino Acids 2013 (November 10, 2013): 1–7. http://dx.doi.org/10.1155/2013/646703.

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Purpose. Previous studies have underlined the effects of the energy drinks containing caffeine end taurine on the cardiovascular system. The aim of this study was to determine acute changes on echocardiographic parameters assessed by conventional echo-Doppler analysis and by speckle tracking echocardiography after the consumption of an energy drink in a young healthy population. Methods. measurement of blood pressure, electrocardiographic, and echocardiographic examination were performed on 35 healthy subjects (mean age 25 ± 2 years, 16 men), at baseline and one hour after the consumption of a body surface area indexed amount of an energy drink (168 mL/m2) containing caffeine (0.03%) and taurine (0.4%). Results. The analysis of left ventricular function showed a significant increase of mean relative values of MAPSE (+11%; ), global longitudinal strain (+10%, ), and left ventricular twisting (+22%, ) in respect to baseline. Also, right ventricular function parameters appeared significantly increased after energy drink consumption, as TAPSE (+15%, ), global, and free wall right ventricular longitudinal strain (+8%, ; +5%, , resp.). Conclusion. In conclusion, the consumption of the ED in our population showed a significant increase of right and left ventricular myocardial function, suggesting a possible positive inotropic effect related to the substances contained therein.

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Hernández Burgos, Paula M., and Angel López-Candales. "Changes in Mitral Annular Ascent with Worsening Echocardiographic Parameters of Left Ventricular Diastolic Function." Scientifica 2016 (2016): 1–4. http://dx.doi.org/10.1155/2016/6303815.

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Background. While the mitral annular plane systolic excursion (MAPSE) has been suggested as a surrogate measurement of left ventricular ejection fraction, less is known about the relative value of mitral annular ascent (MAa).Methods. Our database was queried for complete transthoracic echocardiograms performed for any clinical indication. Baseline echocardiographic measurements were compared to determine any correlation between MAa and traditional Echo-Doppler echocardiographic measures to characterize left ventricular diastolic dysfunction (LVDD).Results. Patients with normal LV diastolic function were younger (41±13years) than patients with LVDD (stage 1:61±13years; stage 2:57±14years; and stage 3:66±17years;p=0.156). LV ejection fraction decreased in patients with stage 2 LVDD (63±17%) and was further reduced in patients with stage 3 LVDD (28±21;p=0.003).Discussion. While a vigorous MAa excursion was seen in patients with stage 1 LVDD, MAa significantly decreased in stage 2 and stage 3 LVDD patients. Our results highlight the importance of atrioventricular coupling, as MAa motion seems to reflect changes in left atrial pressure. Additional studies are now required to better examine atrioventricular interactions and electromechanical coupling that might improve our assessment of LV diastolic function.

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Aldoori, Mahasen, Najeeb H. Mohammed, and Ghazi F. Haj. "Role of Two- Dimensional Speckle Tracking Strain versus Conventional Echocardiography in the Assessments of Left Ventricular Systolic Function in Middle-aged Hypertensive Patients." Journal of the Faculty of Medicine Baghdad 61, no. 1 (July 29, 2019): 30–38. http://dx.doi.org/10.32007/jfacmedbagdad.611893.

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Background: Global longitudinal strain (GLS) echocardiography is a new technique that can be used to detect an early left ventricular dysfunction in various heart diseases . Systemic hypertension is a major risk factor for cardiovascular accidents. The early management of its complication on the heart plays an important role in the outcome of the disease. Hypertension is associated with changes in several aspects of left ventricular structure, function, and systolic strains. Various echocardiographic techniques are used to evaluate left ventricular function in hypertensive patients. Objectives: To evaluate the effectiveness of speckle tracking global left ventricular strain percentage (GLVS%) in the assessments of left ventricular systolic function in comparison to conventional echocardiography in middle -aged hypertensive patients. Patients and Methods: The study was conducted from December 2017 till November 2018 at the Department of Echocardiography and Catheterization / Baghdad Teaching Hospital – Medical C ity,Baghdad, Iraq. One hundred and four hypertensive patients classified as ; group I that involved patients with reversed E/A ratio on PW Doppler with reversed Pulsed Wave ( PW) tissue Doppler study and group II with patients having normal E/A ratio on PW Doppler and reversed Eprime/A prime on PW tissue Doppler study . The control (group III) recruited from the relative of the patients included 104 sex and age -matched healthy individuals . A detailed history with the recommended investigations and blood pressure measurements was performed for all participants. Additionally, echocardiography examination was implemented using standard methods, considering eftventricle (LV) internal dimension, LVejection fraction percentage (LV EF%) , LV diastolic function using PW Doppler and lateral mitralannular tissue Doppler Sprime,Mitral annular plane systolic excursion (MAPSE) and global LVspeckle tracking strain percentage (GLVS%). Results: Group I included 76 patients with a mean age of (48 ± 6.6 years) and group II included 28 patients with a mean age of (48 ± 6.6 years). A ll the participants had normal EF% (> 60%), MAPSE (>13 mm), and S prime (> 9 cm /sec) while there were a significantly decreased GLVS% in the diseased groups in comparison to the control one (P < 0.005) being less in group II (-14 ± 1 %) than in Group I (- 16 ± 1 %) . In addition to a significant negative linear correlation between GL V S% with that of pulse pressure and IVST respectively ( p=0.04) and with that of E/A ratio and E/E prime ratio (p=0.001). Conclusions: GLVS% is a better method in the assessment of LV systolic function in inmiddle- aged hypertensive patients than conventional echo methods since it could detect an early impairment in LV systolic function despite preserved LV systolic function measured by the conventional echo methods

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Giovanardi, Paolo, Enrico Tincani, Marco Maioli, and Stefano Tondi. "The Prognostic Importance of TAPSE in Early and in Stable Cardiovascular Diseases." Journal of Cardiovascular Development and Disease 7, no. 1 (January 15, 2020): 4. http://dx.doi.org/10.3390/jcdd7010004.

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The identification of predictors of major cardiovascular events (MACES) represents a big challenge, especially in early and stable cardiovascular diseases. This prospective study comparatively evaluated the prognostic importance of left ventricular (LV) and right ventricular (RV) systolic and diastolic function, pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR) in a stable patient’s cohort with cardiovascular risk factors. The LV ejection fraction, mitral annular plane systolic excursion (MAPSE), tricuspid annular plane systolic excursion (TAPSE), functional mitral regurgitation (FMR), doppler tissue imaging of mitral and tricuspid annulus with systolic and diastolic peaks estimation, tricuspid regurgitation velocity (TRV), pulmonary velocity outflow time integral (PVTI), mean pulmonary artery pressure (MPAP) and PVR were estimated at enrollment. During the follow-up, MACES and all-cause mortality were recorded. 369 subjects with or without previous MACES were enrolled. Bivariate analysis revealed LVEF, TAPSE, MPAP, TRV, PVR, LV diastolic function, and FMR were associated with the endpoints. When computing the influence of covariates to the primary endpoint (all-cause mortality and MACES) through Cox analysis, only LV diastolic function and TAPSE entered the final model; for the secondary endpoint (MACES) only TAPSE entered. TAPSE was able to predict MACES and all-cause mortality in early and stable cardiovascular diseases. The use of TAPSE should be implemented.

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Koestenberger, Martin, Bert Nagel, William Ravekes, Alexander Avian, Gerhard Cvirn, Thomas Rehak, and Andreas Gamillscheg. "Reference Values of the Mitral Annular Peak Systolic Velocity (Sm) in 690 Healthy Pediatric Patients, Calculation of Z-Score Values, and Comparison to the Mitral Annular Plane Systolic Excursion (MAPSE)." Echocardiography 31, no. 9 (February 7, 2014): 1122–30. http://dx.doi.org/10.1111/echo.12541.

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Giustiniano, Enrico, Sergio Palma, Massimo Meco, Umberto Ripani, and Fulvio Nisi. "Echocardiography in Prone Positioned Critically Ill Patients: A Wealth of Information from a Single View." Diagnostics 12, no. 6 (June 14, 2022): 1460. http://dx.doi.org/10.3390/diagnostics12061460.

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In critically ill patients, standard transthoracic echocardiography (TTE) generally does not facilitate good image quality during mechanical ventilation. We propose a prone-TTE in prone positioned patients, which allows clinicians to obtain a complete apical four-chamber (A-4-C) view. A basic cardiac assessment can be performed in order to evaluate right ventricle function and left ventricle performance, even measuring objective parameters, i.e., tricuspid annular plane systolic excursion (TAPSE); pulmonary artery systolic pressure (PAP), from the tricuspid regurgitation peak Doppler velocity; RV end-diastolic diameter and its ratio to left ventricular end-diastolic diameter; the S’ wave peak velocity with tissue Doppler imaging; the ejection fraction (EF); the mitral annular plane systolic excursion (MAPSE); diastolic function evaluation by the mitral valve; and annular Doppler velocities. Furthermore, by tilting the probe, we can obtain the apical-five-chamber (A-5-C) view, which facilitates the analysis of blood flow at the level of the output tract of the left ventricle (LVOT) and then the estimation of stroke volume. Useful applications of this technique are hemodynamic assessment, titration of fluids, vasoactive drugs therapy, and evaluation of the impact of prone positioning on right ventricle performance and right pulmonary resistances. We believe that considerable information can be drawn from a single view and hope this may be helpful to emergency and critical care clinicians whenever invasive hemodynamic monitoring tools are not available or are simply inconvenient due to clinical reasons.

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Beck, H. P., and T. Beyer. "Lattice potentials as an instrument in crystal chemistry. III. Applications to crystal surfaces1." Zeitschrift für Kristallographie - Crystalline Materials 212, no. 8 (January 1, 1997). http://dx.doi.org/10.1524/zkri.1997.212.8.572.

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AbstractSome applications of surface potential and MAPSE (Madelung Part of Surface Energy) calculations are presented. MAPSE is a useful tool for the prediction of crystal morphologies and the terminating ion layer in crystal, surfaces. The surface specific part of a lattice potential, called epi-potential can be used to analyse the range of surface effects and to study the potential topology in epi-potential maps. These maps of crystal surfaces show the positions of the next one or two missing ion layers above the surface as active centres for reactions and adsorption phenomena.We present here calculations for NaCl, CaF

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Balasubramaniyan, Jayanti Venkata, Ashutosh Prasad Tripathi, and J. S. Satyanarayana Murthy. "Mitral Annular Plane Systolic Excursion (MAPSE) as a Simple Index for Assessing Left Ventricular Function: An Observational Study." Journal of Pharmaceutical Research International, December 17, 2021, 163–70. http://dx.doi.org/10.9734/jpri/2021/v33i59b34366.

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Background: Mitral annular plane systolic excursion (MAPSE) has been proposed as a parameter for assessing left ventricular function. The assessment of LVF has major diagnostic and prognostic implications in patients with cardiovascular diseases. LVF is measured by Left Ventricular Ejection Fraction, however the accuracy of LVEF estimation by two dimensional echocardiography is limited especially in patients with poor image quality. Mitral annular plane systolic excursion (MAPSE) measurement predicts left ventricular function even in conditions with suboptimal echo window. Objective: To assess the correlation of MAPSE derived LVEF with LVEF measured by Modified Simpson’s method. Methods: This is a cross sectional study which included 279 patients admitted at our tertiary care hospital from December 2019 to March 2020 and the patients were divided in two groups. Group A – Patients with LVEF>= 50% and Group B – Patients with LVEF<50%. All patients underwent 2D echocardiographic examination using Modified Simpsons’ method and MAPSE measurement. The VIVID E9, VIVID T8, VIVID E95 and PHILIPS echocardiography machine was used for the non-invasive measurements. MAPSE was recorded at medial and lateral mitral annuli in the apical four-chamber approach. Results: On analysis, a cut off value for average MAPSE-S (medial mitral annuli) was 8.5 was obtained, denoting preserved LV function with sensitivity of 81.7%, specificity of 84.9%, positive predictive value of 91.6% and negative predictive value of 84.9%. The AUC for MAPSE-S was 0.822. Similarly, the cut off value of average MAPSE-L (lateral mitral annuli) was 7.5 denoting impaired LV functions with an AUC of 0.826, sensitivity of 82.8%, specificity of 72.0%, positive predictive value of 85.6% and negative predictive value of 72.0%. The AUC of 82.6% was observed for MAPSE-L. Conclusion: MAPSE reflects longitudinal myocardial shortening. MAPSE is a rapid and sensitive echocardiographic parameter for assessing normal LV function and global LV systolic dysfunction.

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Moderato, L., S. M. Binno, G. Pastorini, C. Dallospedale, G. Benatti, D. Lazzeroni, M. Piepoli, D. Aschieri, and G. Q. Villani. "P1555 Delta mapse: an easy-to-use tool to evaluate coronary artery stenosis during dypiridamole pharmacological stress echocardiography." European Heart Journal - Cardiovascular Imaging 21, Supplement_1 (January 1, 2020). http://dx.doi.org/10.1093/ehjci/jez319.976.

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Abstract Background Dypiridamol stress echocardiography (DSE) is an important tool for detecting reversible ischemia in patients with suspected coronary artery disease (CAD); nonetheless the results of the test are related to visualization of wall motion abnormalities, moderately operator-dependent, and left anterior descending (LAD) artery reserve, resulting in a moderate sensibility and specificity. Aim of our study was to evaluate whether an an easy-to-use parameter like mitral annular plane systolic excursion (MAPSE) could be useful to identify CAD during DSE. Methods We prospectively enrolled 300 patients with suspected CAD and perform a DSE; at rest and peak MAPSE was acquired. 59 patients with reversibile ischemia during stress echocardiography (positive) were referred to perform coronary angiography. Patients were divided according to MAPSE behaviour during DSE: group 1 (MAPSE ≤ 0) and group 2 (delta MAPSE > 0 mm). Results The mean age of was 63 ± 11 years, male gender was prevalent (73%); no differences were found in risk factors and left vetnricular ejection fraction (LV-EF) between two groups.Coronary arteries were normal in 14 patients (23%), while significant stenosis (>70%) was found in 45 patients (77%); in 31 patients (53%) left main (LM) or proximal LAD artery were involved, while in 17 (29%) and 22 (37%) right coronary artery and circumflex artery were affected respectively. Patients with CAD showed a lower (blunted or no increase) MAPSE after dypiridamole infusion, with a significative difference in Delta Mapse (Mapse peak-Mapse rest) between groups (0,2 mm vs 2,8 mm p = 0,004) (Figure 1B). By using a Receiver Operating Curve, the Area under the curve was 0,757, with the best cut-off value for CAD prediction at Delta Mapse= +2.5 mm (sensibility 0,667 and specificity 0,809 – p = 0.012 - Figure 1b). In particular, Delta Mapse was able to predict LM/LAD stenosis (Figure 1B AUC = 0.679 ;p = 0.019), rather than right coronary artery and circumflex artery disease, with higher predictivity than delta LV-EF (AUC = 0.577; p = 0.077). Discussion To our knowledge, this is the first study that compared the behaviour of MAPSE during dypiridamole infusion in patient with and withouth coronary artery disease. MAPSE is a well-known surrogate of longitudinal systolic function and have increased sensitivity over traditional methods of systolic performance such as LV-EF; in this context, dypiridamole induced reversible ischemia could affect prematurely MAPSE then EF or wall motion abnormalities. In our study, in patients with evidence of reversible ischemia during DSE, a blunted or no increase of MAPSE was able to predict CAD, mostly driven by LM/LAD disease, on top of other well known markers of ischemia. Incorporating this easy-to-use parameter could improve specificity of DSE and strenghten the suspect of reversibile ischemia when clear wall motion abnormalities are not found. Abstract P1555 Figure 1A and 1B

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Moderato, L., S. Binno, G. Rusticali, C. Dallospedale, D. Aschieri, G. Pastorini, and MF Piepoli. "Mitral anular plane excursion predicts coronary stenosis during stress echocardiography with dipyridamole." European Heart Journal - Cardiovascular Imaging 22, Supplement_1 (January 1, 2021). http://dx.doi.org/10.1093/ehjci/jeaa356.198.

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Abstract Funding Acknowledgements Type of funding sources: None. Background Dipyridamole stress echocardiography (DSE) is an important tool for detecting reversible ischemia in patients with suspected coronary artery disease (CAD); nonetheless, the results of the test are related to wall motion abnormalities, moderately operator-dependent, and left anterior descending (LAD) artery reserve, resulting in a moderate sensibility and specificity. Purpose Aim Of our study was to evaluate whether an easy-to-use parameter like mitral annular plane systolic excursion (MAPSE) could be useful to identify CAD during DSE. Methods We prospectively enrolled 512 patients that underwent DSE for suspected CAD; rest and peak MAPSE was acquired; 148 patients were referred to perform coronary angiography, with evidence of severe coronary stenosis in 91 patients. The mean age was 66.7 ±11 years, male gender was prevalent (64%). MAPSE at the peak was significantly different between patients with CAD and patient without (13,4mm vs 16,81 mm , p < 0.001); in fact, patients with CAD showed a blunted or no increase of MAPSE after dipyridamole infusion, with a significative difference in Delta Mapse (Mapse peak-Mapse rest) between groups ( -0.5mm vs 2.8mm) By using a Receiver Operating Curve, the Area under the curve was 0,764 (0.682-0.846), with the best cut-off value of +0.5mm (Sensibility 77%, Specificity 62% - Figure 1), comparabale with traditional methods like LAD reserve, FE reduction or Wall Motion Score Index. Discussion to our knowledge, this is the first study that compared the behavior of MAPSE during dipyridamole infusion in patients with and without coronary artery disease. MAPSE is a well-known surrogate of longitudinal systolic function and has increased sensitivity over traditional methods of systolic performance such as LV-EF: in this context, dipyridamole induced reversible ischemia could affect prematurely MAPSE then EF or wall motion abnormalities. In our study, in patients with evidence of reversible ischemia during DSE, a blunted or no increase of MAPSE was able to predict CAD. Incorporating this easy-to-use parameter could improve the specificity of DSE and strengthen the suspect of reversible ischemia when clear wall motion abnormalities are not found. Abstract Figure. Mean value of Mapse and ROC curve

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Parhi, Deepak Kumar, and Kumar Gaurav Behera. "MITRAL ANNULAR PLANE SYSTOLIC EXCURSION-DERIVED FORMULA TO CALCULATE THE EJECTION FRACTION: A SIMPLE, EASY AND RAPID ECHOCARDIOGRAPHY PARAMETER TO ASSES LEFT VENTRICLE SYSTOLIC DYSFUNCTION." INDIAN JOURNAL OF APPLIED RESEARCH, April 1, 2021, 54–56. http://dx.doi.org/10.36106/ijar/2914485.

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Aims & Objectives - MAPSE DERIVED EJECTION FRACTION CAN BE USED AS AN ALTERNATIVE TO THE CONVENTIONAL ECHOCARDIORAPHIC MEASUREMENTS OF EJECION FRACTION IN EVERY DAY CLINICAL PRACTICE WITH PATIENTS WITH LV SYSTOLIC DYSFUNTION & VALIDATION OF MITRAL ANNULAR PLANE SYSTOLIC EXCURSION DERIVED FORMULA TO CALCULATE THE EJECTION FRACTION IN PATIENTS WITH LV SYSTOLIC DYSFUNCTION EF=4.8XMAPSE(mm)+5.8 in adult male & 4.2X MAPSE(mm)+20 in adult female. Our study is Material and Methodobservational, prospective study with cross sectional data collection done in a period of nov 2018 to nov 2019, The study included 151 adult male and female patients with LV systolic dysfunction fullling all inclusion criteria, LVEF measured by average MAPSE and LVEF measured by visual inspection, M–mode, and modied Simpson's rule was statistically correlated to know the validity of MAPSE derived ejection in case of LVsystolic dysfunction. The current study showed a signicant positive correlation Result - between average MAPSE and EF measured by Mmode (r =0.980, P < 0.001), EF measured by Simpson's rule (r =0.968, P < 0.001), and EF measured by visual inspection(r =0.960, P < 0.001). The mean differences in the EF derived by MAPSE formula between the inter-observer was(-0.14 ± 3.18 ). MAPSE-derived EF using Conclusion - the equation EF = 4.8 × MAPSE (mm) + 5.8 for male and EF = 4.2×MAPSE (mm)+20 for female, is a valid echocardiographic parameter in adult males and females with impaired LV systolic function to asses global LV longitudinal function with minimal interobserver variability.

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Ker, J. "Walking in a straight line–the early detection of cardiomyopathy by the general physician." European Heart Journal 42, Supplement_1 (October 1, 2021). http://dx.doi.org/10.1093/eurheartj/ehab724.0718.

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Abstract Introduction The orientation of muscle fibers in the left ventricle is sophisticated. This peculiar orientation causes the left ventricle to contract in three directions–longitudinal, radial and circumferential. Normal myocardial mechanics is essential for systolic and diastolic function. For the clinician an impairment in longitudinal function is of utmost importance, as it has been shown to be an early marker of left ventricular dysfunction, be that systolic or diastolic. Longitudinal function of the left ventricle can be quantified with tissue velocity imaging (TVI), mitral annular plane systolic excursion (MAPSE) and global longitudinal strain (GLS), as measured by speckle-tracking. GLS measured by speckle-tracking is more technically challenging than measuring MAPSE and furthermore, in a setting with limited resources, not always widely available. Surprisingly, there is a paucity of data on the correlation of GLS to MAPSE. As GLS is the latest modality used to quantify longitudinal function of the LV and TVI is also more technically challenging than MAPSE, MAPSE was the chosen modality to compare to GLS. Furthermore, not all echocardiography systems are equipped for TVI and GLS, whereas that is not the case for MAPSE. MAPSE is therefore an easily acquired skill and widely available. Purpose of this study To determine whether MAPSE, when compared to GLS, is an accurate way to quantify longitudinal function of the left ventricle. If this is shown to be the case, then MAPSE will be a proven, readlily available and easily acquired skill to detect cardiomyopathy, whether primary or secondary to a wide variety of systemic diseases. Methods 175 patients who presented with a variety of primary cardiac diseases and/or systemic diseases with the potential for cardiac involvement were included into the study. 175 patients with normal cardiac function were also included into the study. Left ventricular longitudinal function of the left ventricle was quantified in each patient by means of MAPSE, as well as GLS measured by speckle-tracking. In order to correct MAPSE to body size, MAPSE:LV length was measured. The correlation of MAPSE with GLS was assessed by means of a two-by-two table. Results In this group of 350 patients, split into 2 equal groups-175 with cardiomyopathy, either primary or secondary due to systemic disease, and 175 with no cardiomyopathy, the distinction is clear. The exposore, a GLS <−20% and a MAPSE:LV-lenghth <20% versus no exposure – a GLS <−20% and a MAPSE: LV-length >20% leads to a likelihood ratio of 485 (p=0) and a Pearson correlation of 525 (p=0) that impaired LV-longitudinal function is present. Conclusion A MAPSE: LV-length <20% correlates reliably with an impaired GLS. This is a reliable substitute for GLS and for the general physician who screens for early cardiomyopathy this is a skill that will be cheaper and more easily learned than GLS. Funding Acknowledgement Type of funding sources: None. GLSMAPSE

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