Готові списки джерел за темами / Manufacturing diagram

Добірка наукової літератури з теми "Manufacturing diagram"

Автор: Grafiati
Опубліковано: 7 липня 2024
Оновлено: 7 липня 2024

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Статті в журналах з теми "Manufacturing diagram":

1

Burlyaeva, E. V., V. V. Burlyaev, V. V. Kononenko, and V. S. Tsekhanovich. "Verification of functional models of chemical manufacturing." Fine Chemical Technologies 14, no. 4 (September 15, 2019): 69–76. http://dx.doi.org/10.32362/2410-6593-2019-14-4-69-76.

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A generalized algorithm for the verification of functional models and the rules for the verification of diagrams related by levels of detail were developed in this paper. The algorithm is based on the analysis of a tree which describes the decompose relations in functional diagrams. At each step of the algorithm, a pair consisting of a parent diagram and a functional diagram is selected, and the correlation of the arrows and their roles is checked for both. The formalization of the verification rules was based on the set-theoretic representation of functional diagrams in the form of labeled oriented graphs. The rules make it possible to map the position and roles of the arrows associated with the detailed function block of the parent diagram to the arrows of the child diagram. The following rules for each of the possible arrow roles were established: “input”, “output”, “control”, “mechanism”. The use of the logic programming language PROLOG was proposed for the implementation of the algorithm. A knowledge base structure comprised of 3 interrelated predicates to describe the tree of diagrams, nodes and edges of the graphs was suggested. A query to check the verification rules was formed, and methods of binding variables and fixing roles were considered. The analysis and verification of a fragment of a functional model for the production of vinyl acetate from ethylene was conducted as an example. The functional diagrams for the processes “Condensate separation” and “Vinyl acetate isolation” connected by a decompose relation were developed, their set-theoretic models were constructed, and the use of rules for the verification of each type of arrow were considered.
2

Wang, Yan Hong, Tian Ying Xu, and Zhong Da Tian. "Modeling for Materials and Logistics Optimal System in JIT Flexible Manufacturing." Applied Mechanics and Materials 619 (August 2014): 359–63. http://dx.doi.org/10.4028/www.scientific.net/amm.619.359.

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In this paper, we propose an autonomous material and logistics optimization system model for JIT flexible jobshop. The proposed system consists of a Material Planning subsystem (MPs), a Distribution Planning subsystem (DPs) and a Logistics Control subsystem (LCs). In the proposed system, all subsystems repeat their own optimal decision making as well as exchange production data with others. This mechanism made the whole system a closed-loop information and control system for material and logistics optimization. The unified model constructed up a framework for integrating of the production management, optimal and control in JIT flexible jobshop, through feedback of static materials management information and dynamic logistics information. Unified modeling language (UML) was used as the modeling tool, and several diagrams, including a use cases diagram, a interaction diagram and a sequence diagram, were presented to illustrate the details of the proposed model.
3

Burlyaeva, E. V., V. V. Burlyaev, and V. S. Tsekhanovich. "SET-THEORETIC DESCRITPION OF FUNCTIONAL MODELS OF CHEMICAL MANUFACTURING." Fine Chemical Technologies 12, no. 5 (October 28, 2017): 71–78. http://dx.doi.org/10.32362/2410-6593-2017-12-5-71-78.

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The technique for the formalized description of functional models of chemical manufacturing is developed. The technique is based on graph theory. The model is described as a set of oriented labeled graphs that are hierarchically organized by the decompose relationship. First we describe the conversion of a single diagram to a labeled graph, including adding new nodes and edges. The nodes of the graph correspond to boxes, borders and branching points of the arrows at the diagram. The edges of the graph correspond to the arrows at the diagram. The graph descriptions of the model of base functional relationships such as output-input, output-control, output-mechanism are represented. We develop procedures to convert the border arrows and branch arrows. Conversion of branch arrows is performed depending on changes of the labels of branches. Branching of each arrow corresponds to a subgraph including several edges and perhaps additional nodes. Oriented labeled graphs are described by set-theoretic notation that contains the labels of the edges and the roles of nodes. The hierarchy of diagrams is specified by a decompose relationship, which includes the parent chart, the child chart and the decomposed box. As an example, we present the set-theoretic description of the functional model of vinyl acetate manufacturing. The application of mathematical apparatus built within the framework of graph theory for verification and analysis of functional diagrams based on the proposed formal description is an area for further research.
4

PAPADOPOULOU, EVANTHIA, and D. T. LEE. "THE HAUSDORFF VORONOI DIAGRAM OF POLYGONAL OBJECTS: A DIVIDE AND CONQUER APPROACH." International Journal of Computational Geometry & Applications 14, no. 06 (December 2004): 421–52. http://dx.doi.org/10.1142/s0218195904001536.

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We study the Hausdorff Voronoi diagram of a set S of polygonal objects in the plane, a generalization of Voronoi diagrams based on the maximum distance of a point from a polygon, and show that it is equivalent to the Voronoi diagram of S under the Hausdorff distance function. We investigate the structural and combinatorial properties of the Hausdorff Voronoi diagram and give a divide and conquer algorithm for the construction of this diagram that improves upon previous results. As a byproduct we introduce the Hausdorff hull, a structure that relates to the Hausdorff Voronoi diagram in the same way as a convex hull relates to the ordinary Voronoi diagram. The Hausdorff Voronoi diagram finds direct application in the problem of computing the critical area of a VLSI Layout, a measure reflecting the sensitivity of a VLSI design to random manufacturing defects, described in a companion paper.13
5

Halmešová, Kristýna, Radek Procházka, Martina Koukolíková, Jan Džugan, Pavel Konopík, and Tomasz Bucki. "Extended Continuous Cooling Transformation (CCT) Diagrams Determination for Additive Manufacturing Deposited Steels." Materials 15, no. 9 (April 23, 2022): 3076. http://dx.doi.org/10.3390/ma15093076.

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Continuous cooling transformation (CCT) diagrams are widely used when heat treating steels and represent which type of phase will occur in a material as it is cooled at different cooling rates. CCT diagrams are constructed on the basis of dilatometry measurements on relatively small testing samples (cylindrical shape with diameter of 4mm and length of 11 mm in this study). The main aim of this work was to demonstrate the possibility of evaluating the tensile test properties using mini-tensile tests from miniature volumes (1.4 × 10−7 m3 for one sample) subsequent to determination of the CCT diagram and to extend a standard CCT diagram with information about strength, ductility and the estimated value of the work-hardening coefficient. Mini-tensile tests (MTT) were recently developed due to the low availability of experimental material and have already been successfully used for local mechanical property characterization of metals. CCT diagrams were constructed for 42CrMo4 steel prepared by the laser-directed energy deposition (L-DED) process, for commercially available 42CrMo4 steel conventionally manufactured (for comparison of traditional processing and AM preparation) and for H13 tool steel deposited by the selective laser melting (SLM) process.
6

Koleva, E., G. Kolev, and L. Koleva. "Processing diagram for powder bed additive manufacturing." Journal of Physics: Conference Series 2443, no. 1 (February 1, 2023): 012002. http://dx.doi.org/10.1088/1742-6596/2443/1/012002.

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Abstract This paper presents the developed software for processing parameter simulation and optimization of powder bed additive manufacturing by concentrated energy beams. The simulations are realized by implementation of a normalized processing diagram and analytical model simulating heating of powder layers by a moving linear heat source. Their implementation is demonstrated for electron beam or laser additive manufacturing of industrial alloys. The developed software and the processing diagram provide a useful reference and methodology to support the selection of appropriate processing parameters during the early development stages of concrete powder bed additive manufacturing technology, building production digital twins or development of integrated process management system.
7

Vishnu, Vivek, and Vineet Kumar Dwivedi. "ENHANCEMENT OF PRODUCTION BY LEAN MANUFACTURING METHOD." INTERNATIONAL RESEARCH JOURNAL OF ENGINEERING AND APPLIED SCIENCES 10, no. 1 (January 10, 2022): 01–04. http://dx.doi.org/10.55083/irjeas.2022.v10i01001.

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The thesis proposes a method for introducing lean manufacturing using string diagram in an operating CNG high pressure storage tank manufacturing job shop at Jayfe Cylinder Ltd. Haryana. By applying lean manufacturing using process layout diagram to produce part families with similar manufacturing processes and stable demand, plants expect to reduce costs and lead-times and improve quality and delivery performance. The thesis outlines a method for assessing, designing, and implementing lean manufacturing using process layout diagram, and illustrates this process with an example. A manufacturing cell that produces high pressure steel tank container for commercial & automobile customers is implemented at cylinder tank Machining Centers. The conclusion of the thesis highlights the key lessons learned from this process.
8

Havemo, Emelie. "Visual trends in the annual report: the case of Ericsson 1947-2016." Corporate Communications: An International Journal 23, no. 3 (August 6, 2018): 312–25. http://dx.doi.org/10.1108/ccij-03-2017-0015.

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PurposeDisclosure research has argued that visuals are increasingly used in annual reports as a way to increase readability of the annual report, but comparatively little is known about of diagrams compared to graphs and photographs. The purpose of this paper is to provide a historical account of visuals use in corporate disclosure, with an emphasis on diagrams, to show changes from the 1940s until present-day reporting.Design/methodology/approachVisual research methods were applied to analyze how diagrams, photographs and graphs were used in 69 annual reports of the Swedish telecom company Ericsson.FindingsPhotographs have been used with increasing frequency since the 1950s. Graph and diagram use has increased significantly since the 1990s while photograph use remained stable, suggesting that graphs and diagrams increasingly complement photographs for visually representing the organization in corporate disclosure. Factors explaining the case company’s development include both internal (performance, individual preferences, shifting from a manufacturing-based strategy to a service-based strategy) and external (legislation, transformation of the telecom industry).Originality/valueVisual elements in annual reports are increasingly oriented toward immaterial representations of the organization’s standings and identity and diagrams are increasingly used and contribute to this. This finding motivates further research about diagram use in corporate communication, such as how different diagram types convey accounting messages, and whether diagrams serve as impression management devices. For regulators, it will be important to follow the emerging trend of diagram use, since it is becoming part of reporting practice.
9

Franco-Correa, Julio Cesar, Enrique Martínez-Franco, Celso Eduardo Cruz-González, Juan Manuel Salgado-López, and Jhon Alexander Villada-Villalobos. "Tailored Time–Temperature Transformation Diagram for IN718 Alloy Obtained via Powder Bed Fusion Additive Manufacturing: Phase Behavior and Precipitation Dynamic." Materials 16, no. 23 (November 22, 2023): 7280. http://dx.doi.org/10.3390/ma16237280.

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Experimental and computational approaches were used to study the microstructure of IN718 produced via powder bed fusion additive manufacturing (PBF-AM). The presence, chemical composition, and distribution of stable and metastable phases (γ′′, δ, MC, and Laves) were also analyzed. The information obtained from the microstructural study was used to construct a tailored time–temperature transformation (TTT) diagram customized for additive manufacturing of IN718. Experimental techniques, including differential scanning calorimetry (DSC), scanning electron microscopy, energy dispersive X-ray spectroscopy, and electron backscatter diffraction (EBSD), were employed to establish the morphological, chemical, and structural characteristics of the microstructure. The Thermo-Calc software and a Scheil–Gulliver model were used to analyze the presence and behavior of phase transformations during heating and cooling processes under non-thermodynamic equilibrium conditions, typical of AM processes. Unlike conventional TTT diagrams of this alloy, the diagram presented here reveals that the precipitation of γ′′ and δ phases occurs at lower temperatures and shorter times in AM-manufactured parts. Significantly, the superposition of γ′′ and δ phase curves in the proposed diagram underscores the interdependence between these phases. This TTT diagram is a valuable insight that can help in the development of heat treatment processes and quality control for IN718 produced via PBF-AM.
10

Qiao, Dong Ping, Xiao Juan Liu, and Hao Li. "Research on SysML-Based Modeling for Production Management System." Advanced Materials Research 753-755 (August 2013): 1868–74. http://dx.doi.org/10.4028/www.scientific.net/amr.753-755.1868.

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A comprehensive and systematic model for the production process of large-scale equipment manufacturing can reduce the cost and time of the development and enforcement of the management system. The characters of a modeling language for systems engineering, SysML(Systems Modeling Language), are introduced, and through analyzing the complexity of the production management system for complex product, the basic requirements of its modeling are given; With the practical example in our project, SysML based model is built for production management system of complex product manufacturing ,the application of requirements diagram, use case diagram, block definition diagram, internal block diagram and activity diagram is introduced emphatically.
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Статті в журналах Дисертації

Дисертації з теми "Manufacturing diagram":

1

Jurásková, Anna. "Návrh materiálových toků ve výrobním procesu." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2021. http://www.nusl.cz/ntk/nusl-442902.

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This diploma thesis deals with the issue of material flow and lean manufacturing in a given section of a selected manufacturing company. The diploma thesis focuses on the weaknesses of the current state of the selected workplace and defines the areas for improvement. The first part presents the theoretical basis of the work. The second part of the work is focused on analyzing the current state of the workplace. There are provided solutions for better material flow and to implement selected elements of lean manufacturing in the last part.
2

Buitrón, López Liliana. "Modelo de Lean Manufacturing basado en el ciclo de Deming y desarrollado en Gantt para incrementar la eficiencia en empresas plásticas." Universidad Peruana de Ciencias Aplicadas (UPC), 2019. http://hdl.handle.net/10757/626460.

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A nivel mundial se sabe que, con el transcurrir de los años la industria del sector plástico se mueve en un nivel de crecimiento que está relacionado principalmente a su amplia capacidad de transformación, combinación, durabilidad y otras aplicaciones que si son correctamente empleados contribuyen a mejorar la capacidad de competitividad de las organizaciones haciendo frente a otros convertidores. Sin embargo, esta situación creciente genera que los procesos productivos se encuentren más saturado generando mayores registros de pérdidas en tiempo que impacta en el incumplimiento de la demanda, y ya que las fábricas de producción plástica venden tiempo de máquina esta situación afecta la rentabilidad de la misma. Para poder mitigar estas situaciones se han realizado diversos esfuerzos surgiendo filosofías y metodologías que permitan encontrar la solución a estos problemas, debido a la gran importancia que tiene para las empresas trabajar con la mayor eficiencia en sus procesos y con ello buscar incrementar su disponibilidad productiva para incrementar el volumen de ventas. En tal sentido, se aborda la implementación de la metodología Lean Manufacturing aplicada bajo el soporte del ciclo Deming y cuyo objetivo principal será desarrollar una estrategia en base al ciclo PHVA que permitirá incrementar la eficiencia de máquina de manera sostenida. Su aporte se desarrolla en torno a la aplicación exitosa de la combinación de las herramientas Lean seleccionadas bajo el esquema Deming y desarrolladas bajo un cronograma de Gantt para la solución del caso y que se desarrollan en este artículo pudiendo servir de guía inicial a otros técnicos que buscan incrementar la productividad de sus procesos en otras fábricas del sector.
Worldwide, it is known that, over the years, the industry of the plastic sector is moving at a level of growth that is mainly related to its broad capacity for transformation, combination, durability and other applications that, if correctly used, contribute to improving the capacity of competitiveness of organizations facing other converters. However, this growing situation means that production processes are more saturated, generating higher losses in time that impact on non-compliance with demand, and since plastic production plants sell machine time, this situation affects the profitability of the same In order to mitigate these situations, various efforts have been made to come up with philosophies and methodologies that allow finding the solution to these problems, due to the great importance for companies to work with the highest efficiency in their processes and thus seek to increase their productive availability to increase sales volume In this regard, the implementation of the Lean Manufacturing methodology applied under the support of the Deming cycle whose main objective will be to develop a strategy based on the PHVA cycle that will increase machine efficiency in a sustained manner is approached. Its contribution is developed around the successful application of the combination of the Lean tools selected under the Deming scheme and developed under a Gantt timetable for the solution of the case and that are developed in this article, being able to serve as an initial guide to other technicians who They seek to increase the productivity of their processes in other factories in the sector.
Trabajo de investigaciòn
3

Mayerbergová, Ilona. "Studie operativního řízení výroby." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2012. http://www.nusl.cz/ntk/nusl-223462.

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The goal of this diploma thesis is to use the principles of lean manufacturing to lean workplace and eliminate all forms of waste in this workplace. A part of this work is opti-mal design of the workplace in terms of ergonomics which should have a positive effect on shortening lead time and process cycle efficiency. Shortening the lead time will allow company to respond more quickly to customer requirements and this effect may subsequently lead to the drop in inventories.
4

Schwarz, Adam. "Štíhlé řízení vybrané části výrobního systému." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2020. http://www.nusl.cz/ntk/nusl-417555.

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The work is focused on improving the concept of lean management in a selected engineering company, where analyzes are performed with the help of selected methods and tools to reveal current problems. The data are then processed and based on them, measures for change are proposed with an emphasis on minimizing the rate of waste of time and costs and increasing production efficiency.
5

Teko, Ekoué. "Caractérisation du système de transformation, consommation et propriétés rhéologiques de la purée de niébé "adowè" au Togo." Electronic Thesis or Diss., Université Grenoble Alpes, 2024. http://www.theses.fr/2024GRALI007.

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La malnutrition est une menace importante pour la santé humaine. Au Togo, la purée de niébé appelée localement « Adowè » et potentiellement riche en nutriments peut servir à lutter contre la malnutrition déficitaire. Cependant, force est de constater que la sphère de production et de consommation de cette purée ne cesse de se réduire au fil des ans. Les présents travaux de thèse sur « Adowè » ont donc pour objectifs : (i) de contribuer à la lutte contre la carence nutritionnelle protéino-calorique par l’exploitation des agroressources endogènes comme le niébé (protéines végétales), (ii) de préserver l’environnement face à un rythme croissant de la consommation des protéines animales dans le monde. De ce fait, la valorisation et la réhabilitation de « Adowè » nous ont conduit à l’étude de sa production à l’échelle industrielle. La compression mécanique des graines de niébé pour déterminer leurs états cuits et les propriétés rhéologiques de la purée « Adowè » ont également été examinées dans cette thèse. Les résultats obtenus ont montré que l’état cuit des graines peut être évalué par des grandeurs physiques. L’énergie d’activation de cuisson des graines a également été déterminée. Ainsi, ces paramètres permettront de contrôler énergétiquement le procédé de cuisson des graines. La caractérisation rhéologique de la purée a montré un fluide à seuil pour les purées dont la concentration massique se situe entre 12 et 20%. Au-delà de 20% de concentration, la méthode de mesure de la viscosité par rotation pour la caractérisation rhéologique de « Adowè » n’est pas applicable. De ce fait, la méthode d’extrusion inverse a été exploitée pour quantifier la viscosité de « Adowè » à 31 ± 2 % (masse/masse). Ces résultats sont très intéressants et pourront être utiles pour un passage de la production artisanale à une production industrielle de « Adowè »
Malnutrition is a significant threat to human health. In Togo, cowpea puree, known locally as "Adowè", is potentially rich in nutrients and can be used to fight against malnutrition. However, this puree has seen reduced production and consumption over time. The aim of this thesis is to contribute to the fight against protein-calorie malnutrition through the use of endogenous agricultural resources, such as cowpea seeds (plant proteins). In a world where animal proteins consumption is on the rise, this work also helps to contribute towards environmental preservation. Therefore, promoting the development and rehabilitation of "Adowè" requires us to study its production on an industrial scale. Experiments were carried out to determine the cooked state of the cowpea seeds by mechanical compression. The rheological properties of the "Adowè" puree were also determined. The results obtained show that the cooked state of the seeds could be assessed by physical quantities. The activation energy for the cooking of theseeds has also been determined. These parameters will therefore be the basis for the energetic control of the seed cooking process. Finally, the rheological characterisation of the puree was carried out using two methods. For purees with mass concentrations between 12 and 20%, "Adowè" is a yield stress fluid. Beyond 20% concentration, oscillatory and steady shear viscosity measurements of the puree become intractable. Therefore, back extrusion method was used to quantify the viscosity of the puree at 31±2% (mass/mass). These results are useful fortransitioning from artisanal to industrial production of "Adowè"
6

Sævar, Guðbjörnssonn Alexander, and Yassin Haider Mohammed. "Flow Optimisation for Improved Performance of a Multivariant Manufacturing and Assembly Line." Thesis, KTH, Industriell produktion, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-254443.

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Stoneridge, Inc. is an independent designer and manufacturer of highly engineered electrical and electronic components, modules and systems principally for the automotive, commercial vehicle, motorcycle, agricultural and off-highway vehicle markets. A subsidiary of Stoneridge, Inc. is the company Stoneridge Electronics. They specialise in instrument clusters and tachographs which are manufactured in high quantityin their production plant in Örebro, Sweden. This master thesis focuses on the production line of an instrument cluster called Angela. In close collaboration with Stoneridge Electronics, the goal was to find ways to improve the output of the Angela line by at least 10% compared to the three best months in terms of output from the year before. The Angela line was analyzed thoroughly and from different perspectives using lean tools such as value stream mapping, spaghetti diagram and continuous improvement. Finally, the simulation software ExtendSim was used in order to simulate and analyse different suggestions. The results show that various steps can be taken to improve the efficiency and output of the manufacturing line by as much as 16.3%. Due to the fact that other production lines within the production are similar to the one that the project was carried out on, the project results could be applicable for the other lines as well.
Stoneridge, Inc. är en oberoende designer och tillverkare av högteknologiska elektriska och elektroniska komponenter, moduler och system huvudsakligen för fordonsmarknaderna. Ett dotterbolag till Stoneridge, Inc. är företaget Stoneridge Electronics. De är specialiserade på instrument kluster och färdskrivare som tillverkas i produktionsanläggning i Örebro. Denna examensarbete fokuserar på produktionslinje av ett instrumentkluster som heter Angela. I nära samarbete med Stoneridge Electronics,målet var att hitta sätt att förbättra produktionen av Angela linje med minst 10 % jämförtmed de tre bästa månaderna när det gäller produktion från året innan. Angela-linjen analyserades grundligt och från olika perspektiv med lean verktyg som värdeflödesanalys, spaghetti diagram och kontinuerlig förbättring. Slutligen användes simuleringsprogrammet ExtendSim för att simulera och analysera olika förslag. Resultaten visar att olika steg kan vidtas för att förbättra effektiviteten och produktionen av produktionslinjen med så mycket som 16.3%. På grund av att andra produktionslinjer inom produktionen liknar den som projektet genomfördes på, kan projektresultaten vara tillämpliga för andra linjer också.
7

Bubeníková, Petra. "Návrh štíhlé výroby s využitím produktů Kaizen k zajištění jakosti." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2015. http://www.nusl.cz/ntk/nusl-225304.

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The aim of this thesis is to analyze the current state of the manufacturing process of the company ALFA s.r.o. Moravská Třebová, to submit own suggestions for the introduction of lean production to save time, costs and strengthening of the quality in the company and establish the conditions of implementation, in which is possible to implement specified proposals. The operational objective is also an explanation of benefits that gets the company after implementation of these proposals. The first part gives an overview of lean manufacturing methodologies and with using of selected methods and workflow analysis are determined in the second part the proposals. After their implementation the company can save time, reduce costs and strengthen quality for the customer as a basis for the introduction of lean manufacturing enterprise.
8

Hala, Filip. "Návrh řízení výrobního procesu." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2013. http://www.nusl.cz/ntk/nusl-223925.

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The aim of this diploma thesis is to create and apply a methodology to improve the manufacturing process. Processes for the passage of a contract through the company and activities of the foreman were analyzed. According to this analysis, a methodology was created for continuous improvement of the manufacturing process. This methodology was applied to the data obtained in the analysis. Based on the application of the methodology, actions have been proposed to improve the production process.
9

Holík, Lukáš. "Studie optimalizace výrobních procesů." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2014. http://www.nusl.cz/ntk/nusl-224414.

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The master thesis: „ The Study of Optimization of Production Process“ focouses on optimization of material flow to manufacturing department. First of all there will be shown theoretical approach corresponding with the thesis area and we will introduce production system and portfolio of products. Subsequently a real project will be analyzed and author will describe deficiencies in this project and system. Thanks to theoretical approach there will be found a different solution how to define new system without deficiencies. In the end the author will make a conclusion of newly found solution
10

Lins, de Azevedo Costa Bhianca. "Generation of high drug loading amorphous solid dispersions by different manufacturing processes." Thesis, Ecole nationale des Mines d'Albi-Carmaux, 2018. http://www.theses.fr/2018EMAC0012/document.

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La principale difficulté lors de l'administration orale d'un ingrédient pharmaceutique actif (API) est de garantir que la dose clinique de l’API sera dissoute dans le volume disponible de liquides gastro-intestinaux. Toutefois, environ 40% des API sur le marché et près de 90% des molécules en cours de développement sont peu solubles dans l’eau et présentent une faible absorption par voie orale, ce qui entraîne une faible biodisponibilité. Les dispersions solides amorphes (ASD) sont considérées comme l’une des stratégies plus efficaces pour résoudre des problèmes de solubilité des principes actifs peu solubles dans l’eau et, ainsi, améliorer leur biodisponibilité orale. En dépit de leur introduction il y a plus de 50 ans comme stratégie pour améliorer l’administration orale des API, la formation et la stabilité physique des ASD font toujours l'objet de recherches approfondies. En effet, plusieurs facteurs peuvent influer sur la stabilité physique des ASD pendant le stockage, parmi lesquels la température de transition vitreuse du mélange binaire API-polymère, la solubilité apparente de l'API dans le polymère, les interactions entre l'API et le polymère et le procédé de fabrication. Cette thèse consistait en deux parties qui avaient pour objectif le développement de nouvelles formulations sous forme d’ASD d'un antirétroviral, l'Efavirenz (EFV), dispersé dans un polymère amphiphile, le Soluplus, en utilisant deux procédés différents, le séchage par atomisation (SD) et l'extrusion à chaud (HME). EFV est l’API BCS de classe II de notre choix car c’est un API qui représente un défi pour les nouvelles formulations. En effet, il a besoin d’ASD plus fortement concentrées, pour lesquelles la stabilité chimique et physique pendant le stockage et la dissolution seront essentielles. Dans le but de développer de manière rationnelle les ASDs EFV- Soluplus à forte concentration, la première partie s'est concentrée sur la construction d'un diagramme de phases EFV-Soluplus en fonction de la composition et de la température. Le diagramme de phases a été construit à partir d'une étude thermique de recristallisation d'un ASD sursaturé (85 %m EFV), générée par séchage par atomisation. À notre connaissance, il s'agit de la première étude à présenter un diagramme de phase pour ce système binaire. Ce diagramme de phases est très utile et démontre que la solubilité de l'EFV dans les solutions varie de 20 %m (25 °C) à 30 %m (40 °C). Les ASD de EFV dans le Soluplus contenant plus de 30 %m d'EFV doivent être surveillées pendant le stockage dans des conditions typiques de température. Ce diagramme de phases peut être considéré comme un outil de pré-formulation pour les chercheurs qui étudient de nouvelles ASD d'EFV dans le Soluplus afin de prédire la stabilité (thermodynamique et cinétique). Les ASD préparées par différentes techniques peuvent afficher des différences dans leurs propriétés physicochimiques. La deuxième partie de cette thèse portait sur la fabrication d’ASD par des procédés HME et SD. Cette étude montre clairement que la formation d’ASD est une stratégie de formulation utile pour améliorer la solubilité dans l'eau et la vitesse de dissolution de l'EFV à partir de mélanges binaires EFV-Soluplus. Les procédés de fabrication (HME et SD) se sont révélés efficaces pour générer des ASD dans une large gamme de compositions en EFV. L'optimisation du ratio EFV-Soluplus peut être utilisée pour adapter la libération cinétique des ASD. Le choix d’une charge EFV élevée dépassant la solubilité thermodynamique de l’EFV dans le Soluplus est possible, mais il convient de prendre en compte sa stabilité cinétique dans le temps
The main difficulty when an Active Pharmaceutical Ingredient (API) is orally administered is to guarantee that the clinical dose of the API will be dissolved in the available volume of gastrointestinal fluids. However, about 40% of APIs with market approval and nearly 90% of molecules in the discovery pipeline are poorly water-soluble and exhibits a poor oral absorption, which leads to a weak bioavailability. Amorphous solid dispersions (ASD) are considered as one of the most effective strategies to solve solubility limitations of poorly-water soluble compounds and hence, enhance their oral bioavailability. Despite their introduction as technical strategy to enhance oral APIs bioavailability more than 50 years ago, ASD formation and physical stability remains a subject of intense research. Indeed, several factors can influence the physical storage stability of ASD, among them, the glass transition temperature of the API-carrier binary mixture, the apparent solubility of the API in the carrier, interactions between API and carrier, and the manufacturing process. This thesis consisted of two parts that aim on developing new formulations of ASD of an antiretroviral API, Efavirenz (EFV), dispersed in an amphiphilic polymer, Soluplus, by using two different processes, Spray-drying (SD) and Hot-melt extrusion (HME). EFV is the class II BCS API of our choice because it is a challenging API for new formulations. It needs higher-dosed ASDs, for which chemical and physical stability during storage and dissolution will be critical. Aiming a rational development of high-loaded EFV-Soluplus ASDs, the first part focused on the construction of a temperature- composition EFV-Soluplus phase diagram. The phase-diagram was constructed from a thermal study of recrystallization of a supersaturated ASD (85 wt% in EFV), generated by spray drying. To our knowledge, this is the first study reporting a phase-diagram for this binary system. This phase-diagram is very useful and demonstrated that the EFV solubility in Soluplus ranges from 20 wt% (25 °C) to 30 wt% (40 °C). ASD of EFV in Soluplus containing more than 30 wt% of EFV should be monitored over storage under typical temperature conditions. This phase-diagram might be considered as a preformulation tool for researchers studying novel ASD of EFV in Soluplus, to predict (thermodynamic and kinetic) stability. ASD prepared by different techniques can display differences in their physicochemical properties. The second part of this thesis focused on the manufacturing of ASD by HME or SD processes. This study clearly shows that ASD is a useful formulation strategy to improve the aqueous solubility and the dissolution rate of EFV from EFV-Soluplus binary mixtures. HME and SD manufacturing processes demonstrated to be efficient to generate ASDs in a large range of compositions and loads of EFV. The optimization of EFV to Soluplus ratio can be used to tailor the release kinetics from ASD. The choice of a high EFV load exceeding the thermodynamic solid solubility in Soluplus is possible but it needs the consideration of its kinetic stability over time
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Книги з теми "Manufacturing diagram":

1

Wise, Stephen A. Innovative control charting: Practical SPC solutions for today's manufacturing environment. Milwaukee, Wis: ASQ Quality Press, 1998.

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2

Wise, Stephen A., and Douglas C. Fair. Innovative Control Charting: Practical SPC Solutions for Today's Manufacturing Environment. Quality Press, 2006.

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3

Fair, Douglas C., and Stephen A. Wise. Innovative Control Charting: Practical Spc Solutions for Today's Manufacturing Environment. ASQ Quality Press, 1997.

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4

Mohamed Salleh, Siti Hawa, Mohd Tajuddin Mohd Idris, Nor Bahiyah Baba, Norainiza Saud, Noraziana Parimin, Norsuria Mahmed, Nur Hidayah Ahmad Zaidi, Nur Maizatul Shima Adzali, Rohaya Abdul Malek, and Sri Raj Rajeswari A/P Munusamy. METALURGI UNTUK BUKAN AHLI METALURGI. 2024th ed. PENERBIT UNIVERSITI MALAYSIA PERLIS, 2024. http://dx.doi.org/10.58915/bk2023.022.

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Metallurgy for Non-Metallurgists is a book that explains the basic concepts of metallurgical processes for individuals who do not have a background in the field. This book provides an introduction to the basic concepts of metallurgy including the structure of metals, the properties of different elements, and the classification of metals. It explains the relationship between atomic structure and the mechanical, thermal, and chemical properties of metals, making them easy to understand for non-metallurgists. This book covers extraction methods such as mining, investment, and refining. The process gives the reader an overview of how metals are obtained from ores. The book also covers important topics such as alloying, heat treatment, and powder metallurgy, where it provides a practical overview of how metals are modified and shaped to meet specific needs. The book also discusses the importance of steel and cast iron, non-ferrous alloys, physical metallurgy, electronic metallurgy, failure and corrosion of metals, metal testing, and applications in metallurgy. It also contains complex technical concepts and is accompanied by illustrations, diagrams, and examples. Metallurgy for Non-Metallurgists aims to equip its readers with a solid foundation in metallurgical principles, enabling them to make decisions related to material selection, manufacturing processes, and quality control.

Частини книг з теми "Manufacturing diagram":

1

Wiendahl, Hans-Peter. "The Throughput Diagram — A General, Realistic Model of the Manufacturing Process." In Load-Oriented Manufacturing Control, 89–127. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-57743-7_4.

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2

Papadopoulou, Evanthia, and D. T. Lee. "The Min-Max Voronoi Diagram of Polygons and Applications in VLSI Manufacturing." In Algorithms and Computation, 511–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/3-540-36136-7_45.

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3

Joshi, Sangeeta B., Akhilesh Bhambhani, Yuhong Zeng, and C. Russell Middaugh. "An Empirical Phase Diagram-High-Throughput Screening Approach to the Characterization and Formulation of Biopharmaceuticals." In Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals, 173–205. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470595886.ch8.

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4

Aliyev, I. R., J. F. Mammadov, and Sh R. Rakhimov. "Selection of Information - Measuring Components on the Basis of Layout Diagram of Flexible Manufacturing Cell." In 11th International Conference on Theory and Application of Soft Computing, Computing with Words and Perceptions and Artificial Intelligence - ICSCCW-2021, 124–31. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92127-9_20.

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5

Koch, Julian, Kolja Eggers, Jan-Erik Rath, and Thorsten Schüppstuhl. "Development Process for Information Security Concepts in IIoT-Based Manufacturing." In Lecture Notes in Mechanical Engineering, 316–31. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-18326-3_31.

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AbstractDigital technologies are increasingly utilized by manufacturers to make processes more transparent, efficient and networked. Novel utilization elicits the challenge of preventing deployed information technology from compromising processual security. The digital enabling of formerly analog operation technology, the extensive use of information technology connectivity like MQTT, TCP/IP, Wi-Fi, and the deployment of IoT edge computing platforms create an application scenario for the Industrial Internet of Things (IIoT), which also introduces the associated vulnerabilities, which have been extensively exploited in the past. This paper introduces a development process for information security concepts designed for production scenarios based on the IIoT. This concept is then applied using an illustrative use case from aircraft production. The main contents of the development process include: Formulation of reasonable assumptions, system modelling, threat analysis including risk assessment, recommendation of countermeasures, reassessment after incorporating countermeasures. Specifically, a Data Flow Diagram as the model is developed, and a “risk first” variation of the STRIDE methodology is applied to identify threats and prioritize them. The aforementioned state-of-the-art methodologies are adjusted to our cyber-physical use case in the IIoT. The resulting concept aims to enable manufacturing processes to be digitized as sought. The adjustments to the methodologies are independent from our use case and may be suitable to a broad field of scenarios in the IIoT.
6

Xhafka, Eralda, Elidon Avrami, Gabriele Canton, and Artemisa Mazreku. "Applying the Ishikawa Diagram and Pareto Chart for Defect Reduction in the Manufacturing Industry. A Case Study from a Textile-Producing Company." In Lecture Notes on Multidisciplinary Industrial Engineering, 45–55. Cham: Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-48933-4_5.

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7

Otto, Hans-Peter, and Günter Rath. "State Diagrams A New Programming Method for Programmable Logic Controllers." In Software Engineering for Manufacturing Systems, 27–37. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-0-387-35060-8_3.

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8

Papadopoulou, Evanthia. "L∞ Voronoi Diagrams and Applications to VLSI Layout and Manufacturing." In Algorithms and Computation, 9–19. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/3-540-49381-6_3.

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9

Mietkiewicz, Joseph, and Anders L. Madsen. "Enhancing Control Room Operator Decision Making: An Application of Dynamic Influence Diagrams in Formaldehyde Manufacturing." In Lecture Notes in Computer Science, 15–26. Cham: Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-45608-4_2.

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10

Venkatesh, Kurapati, MengChu Zhou, and Reggie J. Caudill. "Discrete Event Control Design for Manufacturing Systems Via Ladder Logic Diagrams and Petri Nets: A Comparative Study." In Petri Nets in Flexible and Agile Automation, 265–304. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2231-7_10.

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Тези доповідей конференцій з теми "Manufacturing diagram":

1

Algebra, Max-Plus, Aleksey Imaev, and Robert P. Judd. "Block diagram-based modeling of manufacturing systems using." In 2009 American Control Conference. IEEE, 2009. http://dx.doi.org/10.1109/acc.2009.5160099.

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2

Karandikar, Jaydeep, Raul Zapata, and Tony L. Schmitz. "Combining Process Dynamics and Tool Wear in the Milling Super Diagram." In ASME 2010 International Manufacturing Science and Engineering Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/msec2010-34034.

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This paper describes the milling “super diagram” that incorporates limitations to milling productivity and part quality imposed by stability, surface location error (part errors due to forced vibrations), and tool wear. Combinations of axial depth of cut and spindle speed that offer stable cutting conditions with an acceptable, user-defined surface location error level are identified by a gray-scale color coding scheme. The effect of tool wear is included through the force model coefficients (that relate the cutting force to the chip area) used for process dynamics prediction. Because the force model coefficients vary as a function of the volume of material removed, a unique super diagram is constructed for any user-defined volume of material removed with the selected cutter. For example, preferred operating conditions for a new tool can be compared to those for a worn tool. Additionally, user beliefs about data and model accuracy are applied to identify safety margins relative to the deterministic boundaries in the diagrams. Experimental results are provided for an inserted (carbide) cutter used to machine 1018 steel. The wear behavior is characterized as changes in the force model coefficients as a function of the volume of material removed. The flank wear is also measured using an on-machine microscope (to avoid tool removal from the spindle) and correlated to the force model coefficients. Stability diagrams are developed that correspond to the new and worn tool performance and experimental results are provided to verify changes in the process stability due to tool wear.
3

Zahi, S., and A. R. Daud. "Phase diagram, thermodynamics and microstructure of Al-Mg system." In 2010 34th International Electronics Manufacturing Technology Conference (IEMT). IEEE, 2010. http://dx.doi.org/10.1109/iemt.2010.5746713.

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4

Abu-Farha, Fadi, and Brad Deeter. "Sheet Orientation Effects on the Formability Limits of the AZ31B Magnesium Alloy at SPF Conditions." In ASME 2011 International Manufacturing Science and Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/msec2011-50177.

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The formability curves of the AZ31B magnesium alloy were constructed by following a novel approach that best resembles the conditions of actual Superplastic Forming (SPF) operations. Sheet samples were formed at 400 °C and a constant strain rate of 1×10−3 s−1, by free pneumatic bulging into a set of progressive elliptical die inserts. By doing so, the material in each of the formed domes was forced to undergo biaxial stretching at a distinct strain ratio, which is simply controlled by the geometry (aspect ratio) of the selected die insert. Material deformation was quantified using circle grid analysis (CGA), and the recorded planar strains were used to construct the forming limit diagram (FLD) of the material. The aforementioned was carried out with the sheet oriented either along or across the direction of major strains, in order to establish the relationship between the material’s rolling direction and the corresponding limiting strains. Great deviations between the two sets of formability curves are realised, hence a compound forming limit diagram is constructed as an improved way for characterising the material behaviour. The presented pneumatic stretching approach is shown to produce accurate friction-independent formability diagrams, with clear distinction between the safe and unsafe deformation zones, even though the developed diagrams are confined to the biaxial strain region (right side quadrant of an FLD). Moreover, the approach proves to be a viable means for providing formability maps under conditions where traditional mechanical stretching techniques (Nakajima and Marciniak tests) are limited.
5

Ono, N., R. Kainuma, H. Ohtani, K. Ishida, and M. Kato. "Ontology for phase diagram databases." In Proceedings of the Second International Conference on Intelligent Processing and Manufacturing of Materials. IPMM'99 (Cat. No.99EX296). IEEE, 1999. http://dx.doi.org/10.1109/ipmm.1999.792509.

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6

Said, Saloua, Hafida Bouloiz, and Maryam Gallab. "Modeling a Cyber-Resilience-for-Manufacturing Ecosystem Through Causal Loop Diagram." In 33rd European Safety and Reliability Conference. Singapore: Research Publishing Services, 2023. http://dx.doi.org/10.3850/978-981-18-8071-1_p626-cd.

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7

Qi, Yaoguang, Zhuang Li, and Fenna Zhang. "Aapplication of Correlation diagram method in the oil field." In 2018 8th International Conference on Manufacturing Science and Engineering (ICMSE 2018). Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/icmse-18.2018.65.

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8

Maklakova, E. A., and O. A. Gasiyarova. "Speed control system setting of plate mill by bode diagram." In 2017 International Conference on Industrial Engineering, Applications and Manufacturing (ICIEAM). IEEE, 2017. http://dx.doi.org/10.1109/icieam.2017.8076357.

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9

Wang, Weicheng, and Shengling Wang. "Automatic Generation of Partial Order Set Hasse Diagram." In 2017 5th International Conference on Frontiers of Manufacturing Science and Measuring Technology (FMSMT 2017). Paris, France: Atlantis Press, 2017. http://dx.doi.org/10.2991/fmsmt-17.2017.250.

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10

Kou, X. Y., and S. T. Tan. "Modeling Functionally Graded Porous Structures with Stochastic Voronoi Diagram and B-Spline Representations." In 2010 International Conference on Manufacturing Automation (ICMA). IEEE, 2010. http://dx.doi.org/10.1109/icma.2010.36.

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