Дисертації з теми "Manipulative activity"
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Dowd, Kevin William. "The social and political activity of the Cadbury family : a study in manipulative capitalism." Thesis, Swansea University, 2001. https://cronfa.swan.ac.uk/Record/cronfa42781.
Petersson, Malin, and Caroline Bäckström. "How does a Government Lower Primary School in India work with mathematics? - A study on how the teachers’ mathematical beliefs affect the norms operating in the classroom." Thesis, Malmö högskola, Lärarutbildningen (LUT), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-35819.
For our study, we visited a Government Lower Primary School in India to inquiry about how a school in another schooling context teaches mathematics. Our research questions were: How does an Indian Government Lower Primary School work with mathematics? What are the teachers' perceptions of the school’s teaching approach? In addition to these questions and to inquire deeper into this subject, we also investigated How do the teachers’ perceptions and method of teaching connect to Yackel and Cobb’s framework of the different kinds of norms operating in the classroom?We did a qualitative study, staying at the school for three weeks to interview teachers about their method of teaching mathematics as well as observing how they were teaching mathematics and the norms that operated in the classroom. We also gathered information about their mathematics laboratory. During our interviews and observations we came to the conclusion that the school worked with activity-based learning by using manipulative materials. All teachers as well as the principal cooperatively strived to meet the curricula objectives, with the same teaching approach. We also found that the teachers’ values and beliefs about how mathematics should be taught, affect the norms operating in the classroom.This study cannot be generalised for all schools in India or even in this area. This study is a minor study which only considered one particular school which used an interesting teaching method, activity-based learning with manipulatives.
Abakar, Seye N'Dèye Yacine Mar. "Contribution à la production d’une ingénierie didactique en biologie en Centrafrique : cas de l’enseignement de la génétique au secondaire en tenant compte des contraintes locales." Electronic Thesis or Diss., Brest, 2023. http://www.theses.fr/2023BRES0081.
This thesis focuses on the design and analysis of teaching/learning situations in genetics classes in secondary schools in Centra African Republic. It aims to improve the Central African education system by developing practical activities that take account of local constraints. Analysis of ordinary teaching situations in the third year of secondary school showed that the curricula didnot recommend any investigative approaches. We also found that there was no real teaching environment for studying the duplication of chromosome chromatids that precedes cell division, known as mitosis or conformal reproduction. We therefore proposed a situation incorporating a manipulative activity in genetics using locally manufactured teaching aids adapted to the Central African context. The epuipment consisted of painted wooden bars modelling genes, which the pupils were invited to manipulate, thus creating a learning environment.The research shows that the manipulative activity tested in 2021 in the third year contributed to the pupils’understanding of the concepts of gene and mitosis. Despite significant progress in thte acquisition of knowledge, the implementation of the modified situation also posed difficulties, which are analysed here. The theaching-learning situations were analysed using concepts from the Theory of didactic situations (TSD) (Brousseau,1998) and the Theory of joint action in didactics (TACD) (Sensevy, 2011) wich at the same time have similarities and specifities
Wilson, Catherine. "IPads in the early childhood science classroom: An exploration of iPad use in hands-on science activities." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/132659/2/Catherine%20Wilson%20Thesis.pdf.
Picchiottino, Mathieu. "Effets des manipulations articulaires sur les marqueurs de l'activité du système nerveux autonome The acute effects of joint manipulative techniques on markers of autonomic nervous system activity: a systematic review and meta-analysis of randomized sham-controlled trials The effect of a single spinal manipulation on cardiovascular autonomic activity and the relationship to pressure pain threshold: a randomized, cross-over, sham-controlled trial What is the effect of spinal manipulation on the pressure pain threshold in young asymptomatic subjects? A randomized placebo-controlled trial, with a cross-over design." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS103.
The use of joint manipulative techniques in the management of some musculoskeletal disorders is ancient, common and supported by scientific literature. However, the mechanisms of action of these techniques are poorly understood. The potential effect of joint manipulative techniques on autonomic activity is a fundamental component of theories relating to their mechanisms of action. One of these theories proposes that joint manipulative techniques may activate the descending pain inhibitory system projecting from the periaqueductal gray matter, a structure that participates in the coordination of pain modulation and autonomic activity. However, this theory has been little explored in the literature. The first objective of this thesis was to evaluate the specific effects of joint manipulative techniques on markers of autonomic activity by conducting a systematic review of the literature. The second objective was to evaluate (i) the specific effect of a single spinal manipulation (thrust technique) on both cardiovascular autonomic activity and pressure pain threshold, and (ii) the relationship between these two variables. Our evaluation of the literature suggests that oscillatory mobilizations, compared to a sham, probably produce a statistically significant increase in skin sympathetic nerve activity. Spinal manipulation and another type of spinal mobilization technique may have no specific effect on autonomic activity. The results of our experimental trial suggest that the application of a single spinal manipulation has no specific effect on cardiovascular autonomic activity and also not on pressure pain threshold. In addition, we found no relationship between pain modulation and cardiovascular autonomic activity after the intervention. Thus, these experimental results do not support the activation of the descending pain inhibitory system by this type of manipulation. To conclude, we suggest further experimental and clinical research in this area. Several recommendations are made in this regard
Joubert, Debra. "Manipulation of neutral invertase activity in sugarcane." Thesis, Link to online version, 2006. http://hdl.handle.net/10019/557.
Winkler, Jonathan Alexander. "Improving antibiotic activity by manipulating bacterial reactive oxygen species metabolism." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12675.
The discovery of antibiotics was one of the most important medical breakthroughs of the twentieth century, having a broad impact on overall life expectancy and public health. Unfortunately, antibiotic discovery has slowed significantly in recent times and has failed to match the rising incidence of antibiotic-resistant pathogens. Gram-negative pathogens are a particularly troublesome threat, primarily because these bacteria possess an outer membrane that prevents many antibiotics from accessing their primary cellular targets. While the discovery of novel antibiotics could help to address these issues, alternative strategies, such as improving the activity of preexisting antibiotics, are also needed. Bactericidal antibiotics have recently been shown to share a common mechanism of cell death, despite having different primary, cellular targets. This shared mechanism involves the metabolic production of reactive oxygen species (ROS), which can damage proteins, lipids, and nucleic acids, and can ultimately result in bacterial cell death. The body of work described here shows that this common mechanism can be exploited to improve antibiotic activity, regardless of the antibiotic's primary mode of action. First, I will describe how bacterial metabolism can be predictably perturbed to increase endogenous ROS production, and that increasing endogenous ROS is sufficient to enhance bacterial sensitivity to treatments with ROS-generating biocides, antibiotics, and immune cell attack. I will then describe work indicating that an ancient antimicrobial agent, silver salts, can also increase endogenous ROS production and potentiate the activity of multiple antibiotic classes. Furthermore, I show that silver salts can increase the outer membrane permeability of a Gram-negative organism. This property is exploited to enable vancomycin, an antibiotic that is specific for Gram-positive bacteria, to work against a Gram-negative organism. Together, this body of work demonstrates that bacterial ROS metabolism can be exploited effectively to enhance. antibiotic activity, which ultimately could result in the discovery and development of novel antimicrobial agents.
Simmonds, Marian. "The effect of neck manipulation on excitability of the motor cortex thesis submission to Auckland University of Technology in partial fulfilment of the degree of Master of Health Science, 2004." Full thesis. Abstract, 2004.
Groenewald, Jan-Hendrik. "Manipulation of pyrophosphate fructose 6-phosphate 1-phosphotransferase activity in sugarcane." Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/1089.
The main aim of the work presented in this thesis was to elucidate the apparent role of pyrophosphate fructose 6-phosphate 1-phosphotransferase (PFP) in sucrose accumulation in sugarcane. PFP activity in sugarcane internodal tissue is inversely correlated to the sucrose content and positively to the water-insoluble component across varieties which differ in their capacities to accumulate sucrose. This apparent well defined and important role of PFP seems to stand in contrast to the ambiguity regarding PFP’s role in the general literature as well as the results of various transgenic studies where neither the downregulation nor the over-expression of PFP activity had a major influence on the phenotype of transgenic potato and tobacco plants. Based on this it was therefore thought that either the kinetic properties of sugarcane PFP is significantly different than that of other plant PFPs or that PFP’s role in sucrose accumulating tissues is different from that in starch accumulating tissues. In the first part of the study sugarcane PFP was therefore purified and its molecular and kinetic properties were determined. It consisted of two subunits which aggregated in dimeric, tetrameric and octameric forms depending on the presence of Fru 2,6-P2. Both the glycolytic and gluconeogenic reactions had broad pH optima and the kinetic parameters for all the substrates were comparable to that of other plant PFPs. The conclusion was therefore that sugarcane PFP’s molecular and kinetic characteristics do not differ significantly from that of other plant PFPs. The only direct way to confirm if PFP is involved in sucrose accumulation in sugarcane is to alter its levels in the same genetic background through genetic engineering. This was therefore the second focus of this study. PFP activity was successfully down-regulated in sugarcane. The transgenic plants showed no visible phenotype under greenhouse and field conditions and sucrose concentrations in their immature internodes were significantly increased. PFP activity was inversely correlated with sucrose content in the immature internodes of the transgenic lines. Both the immature and mature internodes of the transgenic plants had significantly higher fibre contents. This study suggests that PFP plays a significant role in glycolytic carbon flux in immature, metabolically active sugarcane internodal tissues. The data presented here confirm that PFP can indeed have an influence on the rate of glycolysis and carbon partitioning in these tissues. It also implies that there are no differences between the functions of PFP in starch and sucrose storing tissues and it supports the hypothesis that PFP provides additional glycolytic capacity to PFK at times of high metabolic flux in biosynthetically active tissue. This work will serve as a basis to refine future genetic manipulation strategies and could make a valuable contribution to the productivity of South African sugarcane varieties.
Hobson, Piers D. "The regulation and genetic manipulation of Rubisco activity in wheat during stress." Thesis, Lancaster University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422970.
Shanmugam, Sivaramkumar. "Hard functionof the elderly during key turning activity and remote control manipulation." Thesis, University of Strathclyde, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510751.
Tyler, Adam Michael. "Manipulating Rab GTPase activity in wheat to alter gluten quality for breadmaking." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12914/.
Angonin, Diane. "Lineage-specific manipulation of subventricular zone germinal activity for neonatal cortical repair." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1175/document.
Perinatal hypoxia leads to degeneration and delayed maturation of oligodendrocytes and cortical glutamatergic neurons. My PhD project consists in assessing the contribution of neural stem cells (NSCs) of the dorsal subventricular zone (dSVZ, i.e. the largest germinal zone of the postnatal brain) to the spontaneous regenerative attempt observed following such injury as well as its amenability to pharmacological manipulation.The results I have obtained highlight a dynamic and lineage-specific response of NSCs of the dSVZ to hypoxia that results in de novo oligodendrogenesis and cortical neurogenesis. Newborn cortical neurons express appropriate cortical layer markers, supporting their appropriate specification. A pharmacogenomics analysis allowed us to identify small molecules boosting specificly dSVZ NSCs. Pharmacological activation of Wnt/ß-catenin signalling by intranasal GSK3ß inhibitor administration during the recovery period following hypoxia indeed potentiates dorsal SVZ participation to post-hypoxia repair. Gsk3b inhibitor CHIR99021 seems to promote survival of cortical neurons from the dSVZ produced in response to hypoxia. More interestingly, CHIR99021 promotes oligodendrocyte maturation and long term integration in the cortex as well as a long term increased activity of dSVZ NSCs.Altogether, my results highlighted a dynamic and lineage-specific response of dorsal NSCs cells to hypoxia and identify the early postnatal dorsal SVZ as a malleable source of stem cells for cortical repair following trauma that occur early in life. CHIR99021 (a Gsk3b inhibitor) intranasal administration promotes this cortical cellular repair with a long term activation of dSVZ NSCs which increased their production of oligodendrocytes migrating to the cortex and a short term improvement of their maturation, and might allow the integration of cortical neurons they produce
Bell, Pauline. "Manipulation of lipogenase activity in durum wheat for the improvement of pasta colour." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398693.
Dicks, Pamela. "The endocrine control and manipulation of hair follicle activity in the cashmere goat." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/32975.
Chao, Crystal. "Timing multimodal turn-taking in human-robot cooperative activity." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54904.
Jarrin, Annie. "Manipulation génétique des anticorps : analyse moléculaire d'anticorps dirigés contre la glycoprotéine plaquettaire alpha 2b, beta 3 génération, à partir de banques d'expression d'immunoglobulines à la surface de bactériophages, d'anticorps dirigés contre la VE-cadhérine." Grenoble 1, 1996. http://www.theses.fr/1996GRE10176.
Gocheva, Veronika. "Single-molecule nano-manipulation study of the enzymatic activity of the transcription termination factor Rho." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20273.
The Rho protein is a ring-shaped homo-hexameric helicase responsible for prokaryotic transcription termination. Its activity is essential for the regulation of gene expression in E. coli and in other bacteria. The classical model for Rho-dependent transcription termination stipulates that this process is initiated by the specific binding of Rho to the nascent RNA transcript at a Rho-utilization (Rut) site. This initial anchoring is performed through the primary binding site (PBS) of Rho, distributed on the N-terminal domains around the hexameric ring. Next, the RNA transcript is accommodated within Rho's central channel where it contacts an asymmetric secondary binding site (SBS). This leads to motor activation and ATP-fueled translocation on the nascent RNA in the 5'→3' direction, ultimately promoting RNA polymerase (RNAP) dissociation and transcription termination.Despite a wealth of structural, biochemical and genetic data, the molecular mechanisms used by Rho to carry out its biological functions still remain poorly understood and many aspects of this current model are still obscure. These include the activation steps, the mechanism of transcription termination (RNAP dissociation) and the precise mechanisms of translocation and tracking. Several models have been proposed to explain the different mechanistic details of Rho's enzymatic activity. Clear discrimination between these models cannot be performed with classical ensemble assays because the activation of the Rho-RNA complex is rate-limiting. Therefore, quantitative analysis of Rho's mechanisms requires experimentation at the single-molecule level. During the first part of this PhD work I have developed the “tools” required for probing Rho's activity at the single molecule level. These include first design and synthesis of complex nucleic acid constructs adapted for this type of studies. They are composed of a single stranded RNA region containing a natural Rho terminator sequence (with or without hairpin structures) and DNA/RNA “handles” necessary for the subsequent tethering of the constructs. Next, I have implemented a high-resolution magnetic tweezers configuration. This has required the development and the optimization of the setup as well as the data analysis software. This configuration was then used to probe for Rho's single molecule activity. First, by using a real-time analysis based strategy, I have optimized the precise experimental conditions for monitoring Rho's activity with magnetic tweezers. Then, I have used these conditions, in a multiplexing strategy that allows the parallel tracking of several tethered constructs in order to increase the statistics of the observed events. I used this assay to observe for the first time translocation of single Rho molecules and measure the rate and processivity of this translocation. Furthermore this methodology has allowed me to test three independent models for Rho's tracking mechanism proposing that Rho (1) maintains its contacts between the PBS and the loading site upon translocation (a mechanism referred to as “tethered-tracking”), (2) disrupts these initial contacts with Rut, and translocates by remodeling RNA/PBS contacts (“pure-tracking” model), or (3) completely disrupts PBS/Rut contacts upon translocation (“Rut-free tracking”). The obtained results have shown that ATP-dependent Rho translocation at 7pN of external opposing force induces shortening of the nucleic acid constructs tethered between a glass slide and a magnetic bead. This directly demonstrates that Rho is able to translocate by using a “tethered tracking” mechanism. Furthermore detailed inspection of the translocation events has allowed the measurement of the velocity (56 ± 3 nt/s) and processivity (62 ± 3 nt) of Rho translocation at the single-molecule level. Rho thus translocates against at least 7pN of opposing force at rates 2-6 times faster than the speed of transcription by the RNAP (10-30nt/s)
Wu, Kechun. "Solubility and manipulation of disulfides in puroindoline-b: Recombinant puroindoline-b shows antifungal activity." Thesis, University of Ottawa (Canada), 2005. http://hdl.handle.net/10393/27083.
Yu, Yan [Verfasser], and Hilmar [Akademischer Betreuer] Bading. "Manipulation of Neuronal Activity with Light-activated Ion Channels / Yan Yu ; Betreuer: Hilmar Bading." Heidelberg : Universitätsbibliothek Heidelberg, 2013. http://d-nb.info/1177248530/34.
Silva, Sinhara Rishi Malinda. "Manipulating Electromagnetic waves with enhanced functionalities using Nonlinear and Chiral Metamaterials." Scholar Commons, 2017. https://scholarcommons.usf.edu/etd/7443.
Vogel, Holger [Verfasser], Philippe [Akademischer Betreuer] Bastiaens, and Leif [Gutachter] Dehmelt. "Controlling Ras activity by manipulating its localization / Holger Vogel ; Gutachter: Leif Dehmelt ; Betreuer: Philippe Bastiaens." Dortmund : Universitätsbibliothek Dortmund, 2019. http://d-nb.info/1176189697/34.
Walsh, Annabel. "Manipulating dopaminergic activity with bupropion : effects on reward and emotional processing biases implicated in depression." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:08372a77-bc23-42f9-be4e-2f0511124cdf.
O'Grady, Mathew. "Manipulating a conditioning activity to enhance potentiation and its application to jumping and sprinting performance." Thesis, Federtion University Australia, 2017. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/165480.
Doctor of Philosophy
Haymes, Rosemary Y. "The manipulation of cellular ribonucleotide reductose to increase the differential anti-cancer activity of modified nucleosides." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46334.
Salimi-Ghezelbash, Iran. "Modulation of neuronal activity in somatosensory cortex of monkeys during object manipulation using a precision grip." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0011/NQ38832.pdf.
Cassaday, Helen John. "The effects of pharmacological and neurotoxic manipulation of serotonergic activity on latent inhibition in the rat." Thesis, King's College London (University of London), 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294276.
Descarreaux, Martin. "Étude des déficits sensori-moteurs associés aux douleurs lombaires." Doctoral thesis, Université Laval, 2004. http://hdl.handle.net/20.500.11794/17911.
Martin, Brent R. "Optimization of protein and RNA detection methodologies and a new approach for manipulating protein activity in living cells." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3208094.
Title from first page of PDF file (viewed Jun 2, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
Moulis, Gérald. "Une approche cognitive du langage mathématique afin d'assister les activités de manipulation de formules." Toulouse, ENSAE, 1991. https://tel.archives-ouvertes.fr/tel-02045804.
This thesis studies some specifications of a computer system which assists the mathematician. This system is inspired by the "natural" mathematician's activity. Our approach is structured according to the three following questions : I) What is the nature of the mathematical activity ? II) What could we wish for such a system ? III) What could we propose ? We elaborate in part I some cognitive models and situate our work in complement of heuristic reasoning. We analyze the Mathematical Language and recommend the development of a linguistics of mathematics. We study some textual proofs and structure them more especially with variable granularity proof-graphs. In part II we study the apparently simple case of formulae manipulations. We try to elaborate an intelligent mathematical Assistant (Ami) which manages elementary tasks in an Integrated Mathematical Workshop. Part III starts with a state-of-the-art of Computer-Assisted Mathematics (CAMath). We propose a formulae model based on three tied structures (graphical, textual and mathematical) in order to improve formulae manipulation. We study the parsing and the generation of formulae for the case of "sigma". We then exhibit the complexity of the required knowledge to assist the mathematician's activity. Finally, we present the intended mecanisms for using mathematical identities. This thesis illustrates a more general approach: I) the analysis of a conceptual activity from a linguistic point of view II) its transcription in a "natural" activity assisted by a system III) an experimental bottom-up development of this system. In this approach that we call Intercom, the user's role is predominant as it is in the general problematic of Scientific Work Assistance. Intercom has been validated through a set of models and scenarii
Pettengell, Clare Louise. "The isolation of muscle activity and ground reaction force patterns associated with postural control in four load manipulation tasks." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1005203.
Negus, Suzanne Schleehauf. "A Novel Microbial Transglutaminase Derived From Streptoverticillium baldaccii." Thesis, Griffith University, 2002. http://hdl.handle.net/10072/367567.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Biomedical Sciences
Science, Environment, Engineering and Technology
Full Text
Jamieson, David. "Characterisation and manipulation of NQO1 and NQO2 activity and expression and the effect on routinely used and experimental cancer chemotherapeutic agents." Thesis, University of Newcastle Upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423724.
Stein, Sebastian. "Multi-modal recognition of manipulation activities through visual accelerometer tracking, relational histograms, and user-adaptation." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/61c22b7e-5f02-4f21-a948-bf9e7b497120.
Avramopoulos, Petros [Verfasser], Stefan [Akademischer Betreuer] Engelhardt, Stefan [Gutachter] Engelhardt, and Arne [Gutachter] Skerra. "Optical analysis of microRNA activity and therapeutic manipulation of microRNA-29 in vivo / Petros Avramopoulos ; Gutachter: Stefan Engelhardt, Arne Skerra ; Betreuer: Stefan Engelhardt." München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1220320455/34.
Maitre, Julien. "Vieillissement, activité physique et contrôle postural Analyse de l’interaction à travers l’utilisation de manipulations sensorielles multiples et combinées." Thesis, Pau, 2012. http://www.theses.fr/2012PAUU3033/document.
The overall objective of this thesis was to analyse the benefits resulting from the chronic physical activity and the deleterious effects induced by aging on postural control. To this end, different sensory manipulation techniques (e.g. vestibular galvanic stimulation, tendon vibration, electromyostimulation, foam surface) were used in the context of bipedal postural tasks. The main results showed that sensory manipulations affect postural control whatever the age and the level of physical practice of the subject. In addition, the disruptive effects of the sensory manipulations on postural control seem to increase with aging. This postural behaviour could largely result from the involution of the proprioception. When proprioception is disrupted (i.e. tendon vibration), the non-active old subjects group would saturate the proprioceptive system more quickly than the other groups. In contrast, the chronic physical activity would limit the involution of the postural control effectiveness. It could improve the ability of the old subjects to reweight sensory information and enhance the proprioception effectiveness. Hence, a functional postural control optimization might partly compensate the aging effects. Indeed, age-related involutions of sensory systems and central nervous system occurring across life span are inevitable. They prevent the older subjects who practice regular physical activity to maintain a similar ability to cope with postural disruptions in comparison with young athletes
George, Zenas Okon. "Expression and genetic manipulation of Bacillus thuringiensis toxins for improved toxicity and development of a protocol for in vivo selection of toxin variants with improved activity." Thesis, University of Sussex, 2011. http://sro.sussex.ac.uk/id/eprint/7392/.
Gehlen, Jana [Verfasser], Frank Akademischer Betreuer] Müller, and Marc [Akademischer Betreuer] [Spehr. "Pharmacological manipulation of oscillatory activity in the retina of the retinitis pigmentosa mouse model rd10 improves efficiency of electrical stimulation / Jana Gehlen ; Frank Müller, Marc Spehr." Aachen : Universitätsbibliothek der RWTH Aachen, 2020. http://d-nb.info/1218019700/34.
Gehlen, Jana Verfasser], Frank [Akademischer Betreuer] Müller, and Marc [Akademischer Betreuer] [Spehr. "Pharmacological manipulation of oscillatory activity in the retina of the retinitis pigmentosa mouse model rd10 improves efficiency of electrical stimulation / Jana Gehlen ; Frank Müller, Marc Spehr." Aachen : Universitätsbibliothek der RWTH Aachen, 2020. http://d-nb.info/1218019700/34.
Eyermann, Barbara [Verfasser], Stephan A. [Akademischer Betreuer] Sieber, Wolfgang [Gutachter] Eisenreich, and Stephan A. [Gutachter] Sieber. "A Dual Inhibitor Attenuates Biofilm Formation and Virulence in Staphylococcus aureus and Manipulation of ClpP Activity / Barbara Eyermann ; Gutachter: Wolfgang Eisenreich, Stephan A. Sieber ; Betreuer: Stephan A. Sieber." München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1201482755/34.
Theorin, Anna. "To select one hand while using both neural mechanisms supporting flexible hand dominance in bimanual object manipulation /." Doctoral thesis, Umeå : Department of Integrative Medical Biology, Umeå university, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-29805.
Engvall, Margareta. "Handlingar i matematikklassrummet : En studie av undervisningsverksamheter på lågstadiet då räknemetoder för addition och subtraktion är i fokus." Doctoral thesis, Linköpings universitet, Pedagogik och didaktik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-100179.
The aim of this study is to describe, analyse and understand teaching of mathematics in lower primary school. More precisely, the aim is to investigate what this teaching offers pupils in some classrooms in terms of learning, when the content of teaching is written calculation methods for addition and subtraction. Teachers’ and pupils’ activities are in focus, as well as what it is possible for the pupils to learn as a consequence of these activities. Collection of data has been carried out in five classes, starting in spring when the pupils were in second grade and finished by the end of the autumn, when the pupils were in third grade. The video-recorded material comprises a total of 24 lessons. The collected research material has been analysed in two steps, where the first step can be described as empirically oriented and thematical. The theoretical perspective is Activity theory (CHAT) and an analysing tool, inspired by Engeström’s model has guided the second step of the analysis. The result demonstrates four types of teaching activities in mathematics, which leads to possible learning that varies in relation to the educational goals set in the curriculum (Lgr11). It is also shown that teachers and pupils make use of a variety of characteristic methods, which can be sorted into five groups, primarily based on ability aspects that are actualised by different methods. These are methods, where (1) procedures, (2) concepts and connections, (3) mathematical communication and reasoning, and (4) interest and confidence are in focus. There is also a fifth group, but it deviates from the others, as it consists of methods that contribute to (5) stumbling blocks, which in turn means that they become challenges for teachers as well as pupils. The results are discussed in relation to other research about teaching and learning mathematics.
Bayram, Zeki. "Contrôle de l'activité en chimie." Phd thesis, École normale supérieure de Cachan - ENS Cachan, 2005. http://tel.archives-ouvertes.fr/tel-00131864.
Qian, Yang. "Conception et Commande d’un Robot d’Assistance à la Personne." Thesis, Ecole centrale de Lille, 2013. http://www.theses.fr/2013ECLI0005/document.
The purpose of this thesis is to design, model and control of a personal assistant robot used for domestic tasks. In order to make the robot’s design more efficient, a virtual simulation system is built using dynamic simulation software. The kinematic model is set up based on modified D-H principle. The dynamic model is built using the Lagrange theorem and elaborated in Matlab. We also employ an energy-based approach for modeling and its bond graph notation ensures encapsulation of functionality, extendibility and reusability of each element of the model. A hybrid algorithm of combining the Jacobian pseudoinverse algorithm with Rapidly-Exploring Random Tree method is presented for collision-free path planning of a redundant manipulator. An intelligent robust controller based on neural network is introduced for the coordinated control of a mobile manipulator. This method does not require an accurate model of the robot. Unknown dynamic parameters of the mobile platform and the manipulator are identified and compensated in closed-loop control using RBF neural network. A similar control algorithm is presented for coordinated force/motion control of a mobile manipulator suffering both holonomic and nonholonomic constraints. Kinematics and dynamics of a dexterous hand manipulating an object with known shape by rolling contacts are derived. A computed torque control algorithm is presented to ensure firm grip, avoid slippage and well track a given motion imposed to the object. The validation of models and different control laws were made by the co-simulation Matlab / virtual model
Ben, Slimene Imen. "L'impact de la réglementation sur la qualité et le coût de l'audit en Europe." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAG006/document.
This dissertation includes two studies. The first study analyzes the impact of auditor quality and audit regulation on the quality of accounting information, particularly on tradeoff between accrual-based and activity-based earnings management. In the second study in order to better understand the audit fees incurred by listed European companies we analysis the impact of audit regulation on the level of audit fees.Our representative sample is 4219 firms listed on European capital markets from 15 European countries over the period 2007 to 2010. Based on our sample, in the first study we analyze the respective impacts of both auditor quality and audit regulation on earnings quality. We capture auditor quality through using both audit firm size and audit firm industry specialization. We analyze five attributes of audit regulation including namely duration of audit tenure, restrictions on provision of non-audit services, nature of the auditors’ liability, constraints on audit partners’ rotation and obligation of a joint audit.Our main results are as follows: A) Only income-increasing earnings management, which is resulted in overstated earnings, is affected by auditor quality or audit regulations. B) Audit firm expertise influences negatively on the level of the both accrual-based earnings management and activity-based earnings management. Audits provided by large audit firms (i.e. Big4 auditors), have no impact on both accrual-based and activity-based earnings management. C) Audit firm expertise is not the only factor that affects audit quality and earnings quality. Regulation that governs audit services plays a major role in earnings quality as well. Two regulatory attributes have significant beneficial impact on accrual-based earnings management: the nature of the auditor’s liability and the minimal duration of the audit mandate. D) There is a substitution effect between accrual-based and activity-based earnings management, regarding the two attributes of audit regulation that are effective in curbing discretionary accruals. Because of regulatory constraints, the firms that cannot manage accruals upward apply more real activity management, and consequently their earnings are left affected by management actions.In 14 European countries, the diversity of regulations that govern statutory audits provides us with the opportunity to analyze how audit regulation affects audit fees. Using a sample of 4293 European firms over the period 2003 to 2011, in the second study we analyze the attributes of audit regulation, namely duration of audit tenure, restrictions on provision of non-audit services and nature of the auditors’ liability joint audit. Based on Our main results, in addition to usual determinants of audit fees (auditor reputation, firm size, leverage, audit risk…), the three attributes under study impact audit fees significantly. Fees are lower when regulation allows long audit tenure, or non-audit services, as well as when the auditor’s liability is based on tort law
Victor, Aldo. "The effect of spinal manipulation on biceps brachii muscle activity." Thesis, 2016. http://hdl.handle.net/10321/2210.
Background The electromyographic response post-spinal manipulation may support the elucidation of the underlying neurophysiological mechanism of spinal manipulation on motor activity as well as on arthrogenic muscle inhibition. The literature shows conflicting evidence regarding the excitatory or inhibitory nature of the reflexive electromyographic response and the excitability of the homonymous motor neuron pool post-spinal manipulation. The current study investigated whether the electromyographic response post-spinal manipulation is affected by a facilitated golgi tendon organ Ib inhibitory di-synaptic spinal reflex as part of the convergent input on the homonymous motor neuron pool excitability. Objectives The objectives of this placebo-controlled, single-blinded, repeated measures design were: 1) to determine electrical activity and muscle force of the biceps brachii muscle immediately before and after an Activator Adjusting II Instrument placebo spinal manipulation, 2) to determine electrical activity and muscle force of the biceps brachii muscle immediately before and after a C5/C6 spinal manipulation, 3) to compare the electrical activity and muscle force of the biceps brachii muscle between the control and intervention groups pre- and post-test. Method Each participant performed three sets of modified stretching of the biceps brachii muscle with two minute rest intervals between each set in a single appointment, of which at a standardized fourth second during each set an intervention was applied to the ipsilateral C5/C6 segment. The first intervention (AAI 1) entailed the application of an Activator II Adjustment Instrument placebo spinal manipulation; the second intervention (AAI 2) entailed the application of an Activator II Adjustment Instrument placebo spinal manipulation; and the third intervention (SMT) entailed the application of spinal manipulation. One-second electromyography (EMG) segments were taken during the force plateau of each set; the EMG signal was processed through Root Mean Square (RMS) analysis and the muscle force data were obtained by using the Biopac - MP 150 Data Acquisition system and AcqKnowledge analysis software. Results The objective data analysis revealed a noteworthy scientific finding of a medical anomalous inverse relationship between the muscle force and EMG RMS immediately post-spinal manipulation. The immediate post-SMT intervention revealed an increase in the biceps brachii muscle force by 4.76 % and a decrease in the biceps EMG RMS by 9.03 % with a summation of percentage difference between the muscle force and EMG RMS of 13.79 %. The immediate post-placebo AAI 1 intervention showed a decrease in the biceps EMG RMS by 1.86 % and a decrease in the biceps brachii muscle force by 0.85 % with a summation of percentage difference between the muscle force and EMG RMS of 1.01 %. The immediate post-placebo AAI 2 intervention showed a decrease in the biceps EMG RMS by 0.05 % and a decrease in the biceps brachii muscle force by 1.97 % with a summation of percentage difference between the muscle force and EMG RMS of 1.92 %. Conclusion Further research is warranted to add statistical significance to the inverse relationship between muscle force and EMG RMS observed immediately post-spinal manipulation. This knowledge obtained, may have clinical relevance for rehabilitation practitioners and physical therapists by providing evidence based support for the suggestion that optimal management of patients with muscle weakness suspected to be of arthrogenic nature could include the application of spinal manipulation to the segmentally innervated facet joints before traditional strength training is initiated.
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nan, Hong Yu, and 洪毓男. "The Market Valuation of Manipulation of R&D Activity." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/24827823303851432061.
大葉大學
會計資訊學系碩士班
102
In this study we examine the market rewards for firms just meeting or beating earnings targets through manipulating R&D activities, We find that the cumulated equity premium of firms manipulating R&D activities exclusively to meet analysts' expectations is lowerthan for firms thatjust meeting or beating earnings targets without earnings management when return window is set asone day after the earnings announcement. This finding suggests that the market is able to identify firms that would have missed earnings targets without cutting R&D expenditure and then attach an equity penalty to these firms._
Esteves, Rita Maria Santos. "Development of Optogenetic Tools for Manipulating Neuronal Activity and Behaviour in Zebrafish." Master's thesis, 2016. http://hdl.handle.net/10362/21501.
Chang, Hung-Yi, and 張宏毅. "Morphological Manipulation of Cerium Oxide Nanopowders- Preparation, Characterization, and Catalytic Oxidation Activity." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/77539895923167859633.
國立成功大學
化學工程學系碩博士班
93
In this study, CeO2 nanoparticles are synthesized by isothermal and non-isothermal precipitations, respectively. The effects of solvents, temperatures, atmospheres and precursors, on the particle size, shape, crystalline structure, optical properties are investigated. The CeO2 particle evolutions at various temperatures are also explored. Furthermore, the catalytic activities for CO oxidation over various CeO2 nanoparticles are studied. Experimental results show that, via isothermal precipitation, the particle sizes of resulting products are decreased from 20 to 5 nm by decreasing the reaction temperature, which also results in the blueshift of UV absorption due to quantum size effect. As the reaction temperature increases from 30 to 90 oC, the particle shape observed from TEM images transforms from tetragonal to hexagonal attributed to the preferable {111} planes at higher temperature. Moreover, for the CeO2 synthesis in alcohol-water systems, the particle size of resulting products decreases in order as pure water > MeOH/water > EtOH/water ≒ n-PrOH/water ≒ i-PrOH/water ≒ t-BuOH/water > EG/water. Also, the particle size decreases with increasing the amount of alcohol. Since the dielectric constant of reaction medium plays an important role on the nucleation of particles, a comprehensive model correlated between final particle size (dp) and dielectric constant (ε) in mixed solvents (1/dp = A+ B/ε) is obtained. In addition, high oxygen-containing atmosphere, e.g., O2 concentration above 50 %, needle-like CeO2 nanoaprticles are found in the final products. From the evolutions of CeO2 particles at reaction temperatures of 0-90 oC, it is found that the initial Ce(OH)3 precipitate is needle-like at the stage of precipitation above 50 oC. Whereas Ce(OH)3 tiny nanoparticles are precipitated below 50 oC. Afterwards, the Ce(OH)3 needles are broken into nanocrystals and then transformed to be hexagonal-shaped via orientated attachment (OA) and Ostwald ripening (OR) mechanisms. The non-isothermal preparation includes two stages, i.e., precipitating at a given temperature for 5 min, and followed by aging at alternative temperature for 20 hr. The results show that, the final products, synthesized by precipitating at higher temperature (70-90 oC) and then aging at very low temperature (0 oC), are needle-like which are via topotactic mechanism. It is worth to note, the surfaces of CeO2 nanoneedles are preferrably composed of {100} and {110} facets. In addition, the CeO2 nanoneedles can only be obtained starting from the Ce3+ precursor, which can not be formed from the Ce4+ precursor. Furthermore, CO oxidation is used as the model reaction to compare the catalytic activity of various CeO2 nanoparticles. The results show that the activities of catalysts decrease in order as CN-0 (calcined nanoneedles) > N-0(nanoneedles) > CP-90(calcined nanohexagons) > P-90 (nanohexagons) > CERAC(commercial powders). It reveals the activity of catalyst can be enhanced by means of calcination treatment due to the higher degree of crytallinity. Among five catalysts, CN-0 exhibits highest catalytic activity. For example, the CO conversion for CN-0 at 275 oC is about 3.5 times higher than that for commercial powders. This result can be comprehended from the temperature programming reduction (TPR) result of CN-0 catalyst which provides the most surface oxygen sites preferably composed of higher active {110} and {100} facets. In addition, the results of temperature programming desorption (TPD) and IR absorption spectra indicate that stronger adsorption of CO is found for CN-0 than CP-90. Therefore, the morphological manipulation of CeO2 nanoparticles is quite important for determining their catalytic oxidation activity, which also reveals the promise of needle-like CeO2 in future uses.
Dicks, Jason. "The effect of ankle joint manipulation on peroneal and soleus muscle activity in chronic ankle instability syndrome." Thesis, 2016. http://hdl.handle.net/10321/1772.
Purpose: Ankle sprains are amongst the most common injury sustained by athletes and the general public. When an ankle is repeatedly sprained it results in chronic ankle instability syndrome (CAIS). This repeated trauma results in disruption of the afferent nerve supply from the injured joint, which affects the motor neuron pool excitability of the peroneal and soleus muscles resulting in arthogenic muscle inhibition (AMI). Traditional treatment for CAIS focuses on rehabilitation of the affected muscles via strength and proprioceptive training. Recent literature has shown that the addition of ankle joint manipulation resulted in improved clinical outcomes in the treatment of CAIS. The mechanism on how joint manipulation affects AMI is under-investigated especially in extremity joints. Thus this study aimed to determine the immediate effect of ankle joint manipulation on peroneal and soleus muscle activity, by assessing surface electromyography (sEMG) H/M ratio to detect a change in the proportion of the total motor neuron pool being recruited, in participants with CAIS. Methods: The study utilised a quantitative, experimental, pre-test post-test study design. Forty two participants with grade I and II CAIS, aged 18-45 years, were randomly allocated into one of three groups. Group one received a single talocrural joint long axis distraction manipulation, group two received a sham manipulation and group three was the control receiving no intervention. sEMG H/M ratio measurements were taken before and immediately after the intervention using a Biopac wireless emg system. Results: The groups were comparable at baseline for age, gender, body mass index and H/M ratio measurements for the soleus and peroneal muscles (p < 0.050). Intra-group analysis of the soleus muscle H/M ratio showed no statistically significant change over time for the manipulation (p = 0.975) and sham (p = 0.056) groups, with the control group showing a statistically significant (p = 0.019) decrease in the H/M ratio. For the peroneal muscle no statistically significant (p > 0.050) differences were observed in any of the three groups. Inter-group analysis of the soleus muscle H/M ratio measurements showed no statistically significant differences between the three groups (p = 0.470; F = 1.010) over time, with Tukey’s HSD post-hoc test revealing a statistically significant (p = 0.028) difference being observed between the sham and control groups in terms of post soleus muscle H/M ratio measurements. Conclusion: This study failed to show that ankle joint manipulation affects the soleus and peroneal muscles in terms of H/M ratio measurements in participants with CAIS. There may have been a trend of an effect of the sham and manipulation interventions counteracting the muscle fatigue experienced in the control group, however further investigation is required.
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