Дисертації з теми "MALDI mass spectrometry data"
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Momo, Remi Ako-Mbianyor. "MALDI-ToF mass spectrometry biomarker profiling via multivariate data analysis application in the biopharmaceutical bioprocessing industry." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/1939.
Повний текст джерелаRabe, Jan-Hinrich [Verfasser], and Carsten [Akademischer Betreuer] Hopf. "Multimodal FTIR Microscopy-guided Acquisition and Interpretation of MALDI Mass Spectrometry Imaging Data / Jan-Hinrich Rabe ; Betreuer: Carsten Hopf." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177385341/34.
Повний текст джерелаuk, siricordcc@yahoo co, and Cornelia Charito Siricord. "Detection of Phytophthora species by MALDI-TOF mass spectrometry." Murdoch University, 2005. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20070717.125452.
Повний текст джерелаWyatt, Mark Francis. "Analysis of acrylic polymers by MALDI-TOF mass spectrometry." Thesis, Durham University, 2001. http://etheses.dur.ac.uk/3962/.
Повний текст джерелаSiricord, Cornelia Charito. "Detection of Phytophthora species by MALDI-TOF mass spectrometry." Thesis, Siricord, Cornelia Charito (2005) Detection of Phytophthora species by MALDI-TOF mass spectrometry. PhD thesis, Murdoch University, 2005. https://researchrepository.murdoch.edu.au/id/eprint/314/.
Повний текст джерелаSiricord, Cornelia Charito. "Detection of Phytophthora species by MALDI-TOF mass spectrometry." Siricord, Cornelia Charito (2005) Detection of Phytophthora species by MALDI-TOF mass spectrometry. PhD thesis, Murdoch University, 2005. http://researchrepository.murdoch.edu.au/314/.
Повний текст джерелаRodrigues, Lívia Riberti 1988. "Análise de impurezas de formas farmacêuticas sólidas por MALDI Mass Spectrometry Imaging (MALDI-MSI)." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312437.
Повний текст джерелаTexto em português e inglês
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-25T05:33:49Z (GMT). No. of bitstreams: 1 Rodrigues_LiviaRiberti_M.pdf: 1203619 bytes, checksum: a17baf81fa013532bd6c9d451b2336f2 (MD5) Previous issue date: 2014
Resumo: Atualmente, as doenças cardiovasculares constituem uma das primeiras causas de mortes no Brasil e no mundo. Neste cenário, as estatinas constituem uma notável classe de medicamentos redutores de colesterol e têm sido associadas com uma expressiva diminuição da morbidade e mortalidade cardiovascular para pacientes em prevenção primária ou secundária da doença coronariana. Elas agem inibindo competitivamente a enzima HMG-CoA redutase, através da afinidade destes fármacos pelo sítio ativo da enzima. Esta enzima é responsável por catalisar a conversão do substrato HMG-CoA em mevalonato, um dos precursores do colesterol. A crescente necessidade e busca por medicamentos cada vez mais efetivos traz a preocupação na segurança destes produtos para seus usuários. Neste sentido, o conhecimento das impurezas e produtos de degradação torna-se necessário para garantir sua qualidade. Uma técnica muito utilizada para análises de impurezas e degradantes é a espectrometria de massas, pois é uma técnica sensível e seletiva e permite elucidar as estruturas químicas presentes na formulação do medicamento. Sendo assim, amostras de Atorvastatina cálcica foram analisadas pela técnica de espectrometria de massas por imagem (MALDI-MSI), permitindo a quantificação de impurezas do medicamento através da imagem da distribuição dessa impureza no comprimido. Dessa forma, é possível minimizar o preparo de amostra e obter um melhor conhecimento da formulação
Abstract: Currently, cardiovascular diseases constitute one of the first causes of deaths in Brazil and in the world. In this scenario, the statins are a notable class of medicines and cholesterol reducers have been associated with a significant reduction in cardiovascular morbidity and mortality for patients in primary or secondary prevention of coronary heart disease. They act by inhibiting competitively the enzyme HMG-CoA reductase, through the affinity of these drugs by the active site of the enzyme. This enzyme is responsible for catalyzing the conversion of HMG-CoA to mevalonate substrate, one of the precursors of cholesterol. The growing need and search for increasingly effective drugs brings the concern on the safety of these drugs for their users. In this sense, the knowledge of the impurities and degradation products becomes necessary to ensure their quality. A widely used technique for analysis of impurities and degrading is mass spectrometry, because it is a sensitive and selective technique and allows elucidating the chemical structures of the present formulation of the medicinal product. Thus, samples of Atorvastatin calcium were analyzed by the technique of mass spectrometry imaging (MALDI-MSI), which allows the quantification of impurities from the medicine through the image of the distribution of impurity in the tablet. That way, it is possible minimize sample preparation and get a better understanding of the formulation
Mestrado
Ciencias Biomedicas
Mestra em Ciências Médicas
Allwood, Daniel Anthony. "Characterisation and ionisation modelling of matrices in MALDI mass spectrometry." Thesis, University of Hull, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301477.
Повний текст джерелаGuan, Bing. "Characterization of Oligosaccharides and Nanoparticles by MALDI-TOF Mass Spectrometry." ScholarWorks@UNO, 2007. http://scholarworks.uno.edu/td/585.
Повний текст джерелаKirmess, Kristopher Michael. "Investigation of Primary Ion Formation Mechanisms in UV-MALDI-MS Using Excited State Dynamics of Common MALDI Matrices." OpenSIUC, 2015. https://opensiuc.lib.siu.edu/dissertations/1110.
Повний текст джерелаZabet, Moghaddam Masoud. "MALDI mass spectrometry and ionic liquids applications in functional protein analysis /." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=982074360.
Повний текст джерелаOffei, Felix. "Denoising Tandem Mass Spectrometry Data." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etd/3218.
Повний текст джерелаBalluff, Benjamin. "MALDI imaging mass spectrometry in clinical proteomics research of gastric cancer tissues." Diss., lmu, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-155986.
Повний текст джерелаDjidja, Marie-Claude. "Examination of tumour tissues by direct MALDI-mass spectrometry imaging and profiling." Thesis, Sheffield Hallam University, 2009. http://shura.shu.ac.uk/20662/.
Повний текст джерелаTummala, Manorama. "Surfactant-Aided Matrix Assisted Laser Desorption/Ionization Mass Spectrometry (SA-MALDI MS)." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100672049.
Повний текст джерелаSaraiva, Bruno Manuel Santos. "Identification of bacteria by mass spectrometry." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/14317.
Повний текст джерелаIdentification of bacteria is a major part of the diagnosis of a pathogenic infection. In order to positively and confidently identify the bacteria, different techniques can be applied. These techniques are based on different principles, such as phenotypic differences, DNA sequences comparison, mass spectrometry (MALDI-TOF) and the protein content of the bacteria. From comparison of MALDI-TOF for bacteria identification with the other methodologies available, several advantages can be highlighted: lower cost per identification, faster results and higher discrimination power. This work focus on the development of a new application capable of identifying bacteria using MALDI-TOF mass spectrometry. It started by the protein extraction of the samples and the acquisition of the mass profiles of those bacteria. This work proceeded with the development of an application to identify bacteria by comparing the mass profile of an unknown sample with the mass profiles of the bacteria in our database. Using the developed application it was possible to identify both Gram-positive and Gram-negative bacteria to the strain-level. When an identification to strain-level was not possible, it was possible to identify the bacteria to the species-level and in the case the database did not contain an entry of the same species as the sample, the score values were low enough to disregard a possible identification resulting in a low false-positive rate.
A identificação de bactérias é um dos principais componentes do diagnóstico de infeções patogénicas. De modo a se conseguir obter uma identificação podem ser aplicadas diferentes técnicas, tais como, diferenças de fenótipo, comparação de sequências de ADN e a comparação do conteúdo proteico das bactérias. Quando se compara a identificação bacteriana com recurso à espectrometria de massa MALDI-TOF com as metodologias alternativas, podemos destacar diversas vantagens: menor custo por análise, menos tempo para obtenção de resultados e um maior poder discriminatório. Este trabalho tem como foco o desenvolvimento de uma nova aplicação capaz de identificar bactérias com recurso a espectrometria de massa. O trabalho foi iniciado com a extração proteica das amostras e a aquisição dos perfis de massa dessas bactérias. De seguida, prosseguiu-se com o desenvolvimento de uma aplicação para a identificação de bactérias com base na comparação dos perfis de massa da amostra e dos perfis contidos na base de dados. Usando a aplicação desenvolvida conseguiu-se identificar corretamente tanto bactérias Gram-positivas como Gram-negativas. Quando uma identificação da estirpe não foi possível, a aplicação permitiu a identificação da espécie bacteriana e no caso de a base de dados não conter nenhuma entrada que correspondesse a estirpe ou espécie da amostra, os scores obtidos eram suficientemente baixos para uma eventual identificação ser descartada, resultando assim numa baixa taxa de falsos positivos.
Ben-Farag, Suaad Omran S. "Statistical analysis of mass spectrometry data." Thesis, University of Leeds, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.659026.
Повний текст джерелаBroberg, Susanna. "Studies of oligo- and polysaccharides by MALDI-TOF and ESI-ITMSn mass spectrometry /." Uppsala : Dept. of Chemistry, Swedish Univ. of Agricultural Sciences, 2004. http://epsilon.slu.se/a452.pdf.
Повний текст джерелаMaurer, Katja. "Oral brush biopsy analysis by MALDI-ToF Mass Spectrometry for early cancer diagnosis." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-116691.
Повний текст джерелаWilliams, Bradley Allen. "LOCATING CHELERYTHRINE, AN ALKALOID, WITHIN A CYTOSOLIC ENVIRONMENT BY MALDI-TOF MASS SPECTROMETRY." Wright State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=wright1389645518.
Повний текст джерелаSegu, Mohideen Mohamed Zaneer. "TARGET MODIFICATION FOR ENHANCED PERFORMANCE MATRIX ASSISTED LASER DESORPTION IONIZATION (MALDI) MASS SPECTROMETRY." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1674093101&sid=1&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Повний текст джерела"Department of Chemistry." Keywords: Enhanced MALDI, MALDI-MS, On-probe separation, Protein-surface interactions, Sublayers, Surface binding capacity. Includes bibliographical references (p. 130-148). Also available online.
Aboulmagd, Khodier Sarah. "Analysis of Lipids in Kidney Tissue Using High Resolution MALDI Mass Spectrometry Imaging." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19443.
Повний текст джерелаMass spectrometry imaging is indispensable for studying the spatial distribution of molecules within a diverse range of biological samples. Since its introduction, MALDI has become a dominant imaging method, which proved useful to sort out the complexity of lipid structures in biological tissues. The role of cisplatin in the treatment of human malignancies is well-established. However, nephrotoxicity is a limiting side effect that involves an acute injury of the proximal tubule and alterations in the renal lipid profile. This evolved the motivation to study the spatial distribution of lipids in the kidney tissue of cisplatin-treated rats to shed light on the lipid signaling pathways involved. A method for mapping of lipid distributions in kidney sections using MALDI-LTQ-Orbitrap was developed, utilizing the high performance of orbitrap detection. The distribution of kidney lipids in cisplatin-treated samples revealed clear differences with respect to control group, which could be correlated to the proximal tubule injury. The findings highlight the usefulness of MALDI MSI as complementary tool for clinical diagnostics. Furthermore, assessment of the ion images of lipids in cisplatin-treated kidney mostly considered qualitative aspects. Relative quantitative comparisons were limited by the variable influence of experimental and instrumental conditions. Hence, the necessity developed to establish a normalization method allowing comparison of lipid intensity in MALDI imaging measurements of different samples. The method employed an inkjet printer to apply a mixture of the MALDI matrix and dual lipid-metal internal standards. Using ICP-MS, the metal internal standard allowed to confirm the consistency of the matrix and internal standards application. Applying the method to normalize ion intensities of kidney lipids demonstrated excellent image correction and successfully enabled relative quantitative comparison of lipid images in control and cisplatin-treated samples.
Goolsby, Brian James. "Techniques for improved mass spectrometric analysis of biologically relevant molecules produced by MALDI and ESI in the quadrupole ion trap /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004273.
Повний текст джерелаScionti, Vincenzo. "Novel Applications of Mass Spectrometry on Synthetic Polymeric Materials." University of Akron / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=akron1335149657.
Повний текст джерелаBowman, Amber Suzanne. "ENHANCED ANALYSIS OF LIGNIN DEHYDROGENATION OLIGOMERS VIA MASS SPECTROMETRY." UKnowledge, 2018. https://uknowledge.uky.edu/chemistry_etds/104.
Повний текст джерелаOduwole, Elizabeth O. "Generation of a database of mass spectra patterns of selected Mycobacterium species using MALDI-ToF mass spectrometry." Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/2838.
Повний текст джерелаThe genus Mycobacterium is a group of acid–fast, aerobic, slow- growing organisms which include more than 90 different species. A member of this genus, Mycobacterium tuberculosis, belonging to the Mycobacterium tuberculosis complex (MTB), is the causative agent of tuberculosis (TB). This disease is currently considered a global emergency, with more than 2 million deaths and over 8 million new cases annually. TB is the world’s second most common cause of death after HIV/AIDS. About one-third of the world’s population is estimated to be infected with TB. This catastrophic situation is further compounded by the emergence of Multi Drug Resistant tuberculosis (MDR-TB) and in more recent times, Extensive Drug Resistant tuberculosis (XDR-TB). Early diagnosis is critical to the successful management of patients as it allows informed use of chemotherapy. Also, early diagnosis is also of great importance if the menace of MDR-TB and XDR-TB is to be curbed and controlled. As MTB is highly infectious for humans, it is of paramount importance that TB be diagnosed as early as possible to stop the spread of the disease. Traditional conventional laboratory procedures involving microscopy, culture and sensitivity tests may require turnaround times of 3-4 weeks or longer. Tremendous technological advancement over the years such as the advent of automated liquid culture systems like the BACTEC® 960 and the MGITTM Tube system, and the development of a myriad of molecular techniques most of which involves nucleic acid amplification (NAA) for the rapid identification of mycobacterial isolates from cultures or even directly from clinical specimens have contributed immensely to the early diagnosis of tuberculosis. Most of these NAA tests are nevertheless fraught with various limitations, thus the search for a rapid, sensitive and specific way of diagnosing tuberculosis is still an active area of research. The search has expanded to areas that would otherwise not have been considered ‘conventional’ in diagnostic mycobacteriology. One of such areas is mass spectrometry. This study joins the relatively few studies of its kind encountered in available literature to establish the ground work for the application of mass spectrometry, specifically Matrix Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-ToF MS) in the field of diagnostic mycobacteriology. This is an area which is in need of the speed, sensitivity and specificity that MALDI-ToF technique promises to offer. Since this technology is still in its infancy, the use of utmost care in the preparation of reagents, and the handling and storage of the organisms used to generate reference mass spectra for the database cannot be overemphasized. Similarly, the optimization of certain crucial experimental factors such as inactivating method and choice of matrix is of paramount importance. The main aim of this thesis was to generate a database of reference mass spectra fingerprints of selected (repository) Mycobacterium species. This necessitated the standardization of an experimental protocol which ensured that experimental factors and the various instrument parameters were optimized for maximum spectra generation and reproducibility. A standard operating procedure (SOP) for generating the database of reference mass spectra finger print of selected Mycobacterium species was developed and used to investigate the ability of the database to differentiate between species belonging to the same clinical disease complex as well as the nontuberculosis complex. The findings of this study imply that if the defined protocol is followed, the database generated has the potential to routinely identify and differentiate (under experimental conditions) more species of Mycobacterium than is currently practical using PCR and its related techniques. It is therefore a realistic expectation that when the database is clinically validated and tested in the next phase of the study, it will contribute immensely to the diagnosis of tuberculosis and other mycobacterioses. It will also aid in the identification of emerging pathogens particularly amongst the non-tuberculous mycobacteria.
Kempka, Martin. "Improved mass accuracy in MALDI-TOF-MS analysis." Licentiate thesis, Stockholm : Division of Analytical Chemistry, Royal Institute of Technology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-313.
Повний текст джерелаHandley, Kelly. "Statistical analysis of proteomic mass spectrometry data." Thesis, University of Nottingham, 2007. http://eprints.nottingham.ac.uk/10287/.
Повний текст джерелаWandy, Joe. "Unsupervised Bayesian explorations of mass spectrometry data." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/7928/.
Повний текст джерелаPENG, LIJUAN. "MATRIX-ASSISTED LASER DESORPTION/IONIZATION (MALDI) TARGET MODIFICATION FOR ENHANCED PROTEOMICS ANALYSIS AND PLASMA POLYMER CHARACTERIZATION BY MALDI MASS SPECTROMETRY." OpenSIUC, 2010. https://opensiuc.lib.siu.edu/dissertations/207.
Повний текст джерелаFriess, Sebastian D. "Surface topology probing of biomolecules unsing noncovalent receptors : A dissetration on MALDI mass spectrometry /." Zürich, 2003. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=15336.
Повний текст джерелаHeßling, Bernd [Verfasser]. "Complementary application of ESI and MALDI based mass spectrometry in microbial proteomics / Bernd Heßling." Greifswald : Universitätsbibliothek Greifswald, 2013. http://d-nb.info/1032491361/34.
Повний текст джерелаWatson, R. Craig Jr. "Laser-Ionization Time-of-Flight Mass Spectrometry of High Molecular Mass Inorganic Complexes." Thesis, Virginia Tech, 1997. http://hdl.handle.net/10919/35554.
Повний текст джерела
This thesis describes the characterization of a LI-TOF-MS instrument and confirmation of theoretical time-of-flight mass-separation principles. Several test cases demonstrate the instrument's proper operation and calibration for a wide mass range of analytes. Mass spectral results of three organometallic compounds: i. [Ir(dpp)2Cl2](PF6), ii. {[(bpy)2Ru(dpp)]2IrCl2}(PF6)5, and iii. {[(bpy)2Ru(dpp)]2RuCl2}(PF6)5 under a variety of laser ionization and sample preparation conditions are compared. A complete structural characterization of the monometallic complex, [Ir(dpp)2Cl2](PF6), is presented. The two trimetallic analytes fragmented easily, but significant components of the molecules are successfully identified. After optimizing the ionization and analytical procedure, LI-TOF-MS proved useful in the analysis of high molecular mass metal complexes.
Master of Science
Eastwood, Stephanie. "Development of Amine Containing Polymer Modified MALDI Targets for Complex Peptide and Protein Mixture Fractionation Prior to MALDI Mass Spectrometry Analysis." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/dissertations/948.
Повний текст джерелаSubel, Bethany. "Applications of Mass Spectrometry to Poly(electrolytes) and Kinetics." University of Akron / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1248805724.
Повний текст джерелаHunsucker, Stephen Warren. "Time-of-Flight Mass Spectrometry to Characterize Inorganic Coordination Complexes and Cyanobacteria." Diss., Virginia Tech, 2001. http://hdl.handle.net/10919/27150.
Повний текст джерелаPh. D.
Jung, Seokwon. "Surface characterization of biomass by imaging mass spectrometry." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45906.
Повний текст джерелаTengstrand, Erik. "Data analysis of non-targeted mass spectrometry experiments." Doctoral thesis, Stockholms universitet, Institutionen för miljövetenskap och analytisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-116820.
Повний текст джерелаAt the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 4: Submitted.
Bauer, Oliver. "Technology development for oligonucleotide fingerprinting applying multiplexed PNA hybridizations and MALDI-TOF mass spectrometry detection /." [S.l. : s.n.], 2003. http://www.diss.fu-berlin.de/2003/326/index.html.
Повний текст джерелаGemeinhardt, Chelsea Nicole. "DFT STUDIES OF SMALL ORGANIC MOLECULES FOR APPLICATIONS IN MALDI MASS SPECTROMETRY AND SOLAR CELLS." OpenSIUC, 2019. https://opensiuc.lib.siu.edu/dissertations/1752.
Повний текст джерелаAkinapalli, Srikanth. "MICROFLUIDIC DYNAMIC ISOELECTRIC FOCUSING COUPLED TO MATRIX ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY." OpenSIUC, 2016. https://opensiuc.lib.siu.edu/dissertations/1289.
Повний текст джерелаThenstedt, Niklas. "Detektion av hydrolyserad β-laktamantibiotika i plasma med Matrix-Assisted Laser Desorption Ionization – Time of Flight Mass Spectrometry och Liquid Chromatography tandem Mass Spectrometry". Thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84594.
Повний текст джерелаIntroduction Antibiotic resistance is a global growing problem. Piperacillin-tazobactam and cefotaxime are parts of the group β-lactam antibiotics. The common feature is to inhibit the cell wall synthesis by covalent bindings to the peptidoglycan layer and thereby causing lysis of the bacterial cell. E. coli and K. pneumoniae are members of the Enterobacteriaceae which is a part of the human normal flora but also are commonly associated with urinary tract infections which sometimes develops into to sepsis. Extended Spectrum β-Lactamases (ESBLs) are enzymes with hydrolytic abilities acting on β-lactam antibiotics, expressed by Enterobacteriaceae. The qualitative, Matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) can be used to detect chemical compounds in the ratio of mass to charge in accordance to their molecular weight. Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) is a highly sensitive two-step method of quantification which first separate molecules by their polarity attraction force and then by the ratio of mass to charge. Aim The aim of this study was to develop a fast and efficient method to determine degradation of piperacillin-tazobactam and cefotaxime in blood plasma by LC-MS/MS. Method Tenfold dilution of piperacillin-tazobactam in concentrations of 2000 to 2 µg/ml, and cefotaxime in concentrations of 500 to 0,5 µg/ml where analyzed by MALDI-TOF MS, intact and also with the bacteria E. coli and K. pneumoniae with different expression of antibiotic resistance. Optimized concentrations where fixed in blood plasma and then quantified by LC-MS/MS. Result The detection limit by using MALDI TOF MS of hydrolyzed as well as non-hydrolyzed piperacillin-tazobactam was 20/2,5 µg/ml. The detection limit in cefotaxime was 5 µg/ml. Hydrolysis could not be detected in clinically fixed blood concentrations. Detection and quantification of hydrolysis by LC-MS/MS was possible in a concentration of three bacteria colonies/50 µl. Conclusion It is possible to detect hydrolysis in both MALDI TOF MS and LC-MS/MS. A larger amount of bacteria than expected was needed to demonstrate hydrolysis In LC-MS/MS.
Djidja, M.-C., V. A. Carolan, Paul M. Loadman, and M. R. Clench. "Method development for protein profiling in biological tissues by matrix-assisted laser desorption/ionisation mass spectrometry imaging." Wiley, 2008. http://hdl.handle.net/10454/4568.
Повний текст джерелаSchumacher, Joshua. "Carbon Nanotube Enhanced MALDI MS: Increasing Sensitivity Through Sample Concentration." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3595.
Повний текст джерелаHettick, Justin Michael. "Optimization and utilization of MALDI 193-nm photofragment time-of-flight mass spectrometry for peptide sequencing." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/1197.
Повний текст джерелаWoldegiorgis, Andreas. "Fabrication of new silica nano structures and development of new concepts for MALDI-TOF mass spectrometry." Doctoral thesis, Stockholm : Tekniska högsk, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-79.
Повний текст джерелаJia, Wei Jie. "The application of MALDI and tandem reflectron TOF mass spectrometry to the analysis of biomolecular ions." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321839.
Повний текст джерелаReeves, Savanah Gail. "Condensed tannin characterization with FT-ICR MALDI mass spectrometry and separation with saw-tooth gradient HPLC." Miami University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=miami1591185101154831.
Повний текст джерелаWalton, Barbara Lynn. "A Study of Silver: an Alternative Maldi Matrix for Low Weight Compounds and Mass Spectrometry Imaging." Thesis, University of North Texas, 2014. https://digital.library.unt.edu/ark:/67531/metadc499981/.
Повний текст джерелаLee, Wooram. "Protein Set for Normalization of Quantitative Mass Spectrometry Data." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/54554.
Повний текст джерелаMaster of Science