Дисертації з теми "Major histocompatibility complex I (MHCI)"
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Glithero, Ann. "Presentation of glycopeptides by major histocompatibility complex (MHC) class I." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267901.
Повний текст джерелаGodinez, Ricardo. "Comparative Genomics of the Major Histocompatibility Complex in Amniotes." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10685.
Повний текст джерелаQin, Jinyi. "Characterisation of the central region of the sheep major histocompatibility complex." Thesis, Curtin University, 2008. http://hdl.handle.net/20.500.11937/375.
Повний текст джерелаFeichtlbauer-Huber, Petra. "Einfluss des major histocompatibility complex (MHC) auf die Nematodenanfälligkeit beim Schaf." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964457458.
Повний текст джерелаMiltiadou, Despoin. "Characterization of the ovine Major Histocompatibility Complex (MHC) class I genes." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29891.
Повний текст джерелаLim, Elaine Hsuen. "Study of Fugu orthologues of mammalian MHC class III genes." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266288.
Повний текст джерелаLo, Yun-hua. "A preliminary survey of MHC class I sequences in mandrills." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648208.
Повний текст джерелаQin, Jinyi. "Characterisation of the central region of the sheep major histocompatibility complex." Curtin University of Technology, School of Biomedical Sciences, 2008. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=118317.
Повний текст джерелаIn addition, a previously identified short tandem repeat locus designated BfMs believed to be in the CFB locus was mapped to an intron within the adjacent SKI2VL locus. Single nucleotide polymorphisms (SNPs) were identified by analysing homologous sequences from a minimum of five individual sheep. In total 33 SNPs were discovered distributed over eleven distinct loci. Allele frequencies for SNPs from ten of these loci were determined and reported for a panel of 71 sheep comprising 58 unrelated sheep from the Rylington Merino flock plus a further 13 unrelated parental animals from a three generation half sibling sheep pedigree. The availability of an independently confirmed pedigree constructed from a three generation half sibling sheep family permitted the identification by deduction of central region MHC haplotypes based on a panel of SNPs derived from 10 loci. This is the first reporting of haplotypes covering this region of the sheep MHC. Analysis of SNP panel genotypes in the cohort of 71 unrelated sheep using the expectation maximization algorithm permitted the prediction of a group of approximately 20 haplotypes, which accounted for more than 90% of the expected haplotype distribution. Four of these predicted haplotypes were also present in the known haplotype cohort deduced from the sheep pedigree. Analysis of pairwise linkage disequilibrium between SNP loci in the cohort of 71 unrelated sheep showed a centre-most region displaying relatively high levels of linkage disequilibrium which was bounded by two regions displaying more variable linkage disequilibrium.
It is hypothesised that this mid region of the central region of the sheep MHC may be a block like structure characterized by low recombination similar to those that have been widely described in the human and mouse genomes. The discoveries reported in this thesis provide a more accurate and detailed description of the central region of the sheep MHC together with a panel of SNPs, which reflect the diversity of this important genomic region which is known to be associated with immune responsiveness. The description, for the first time, of central region haplotypes provides a practical means of seeking candidate loci associated with disease resistance and productivity traits. The application of molecular techniques will enhance the rate at which the genomic composition of this region is elucidated and the work described in this thesis will contribute to final characterization of this important complex in health and disease.
Parker, Kay Elizabeth. "Genetic and immunological studies on class I MHC antigens of the rat." Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278511.
Повний текст джерелаRogers, Sarah Louise. "Characterisation of C-type lectin-like receptor genes in the chicken MHC." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271871.
Повний текст джерелаMawas, Fatme Omar. "Expession of MHC molecules on rat cardiac cells : its effect on their immunogenicity in vitro." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283719.
Повний текст джерелаLill, Jennie Rebecca. "Characterisation of MHC class I tumour antigens." Thesis, Nottingham Trent University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366082.
Повний текст джерелаLee, Chee Yang. "Characterisation of the ovine major histocompatibility complex class II region." Thesis, Curtin University, 2009. http://hdl.handle.net/20.500.11937/1849.
Повний текст джерелаRamsay, Joshua David. "Development of a DNA microarray for detection of expressed equine classical MHC class I alleles in a defined population." Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Thesis/Fall2009/j_ramsay_112309.pdf.
Повний текст джерелаTitle from PDF title page (viewed on Jan. 14, 2010). "College of Veterinary Medicine." Includes bibliographical references (p. 12-13).
Scott, Adrian Phillip. "Investigation of major histocompatibility complex (MHC) associations in sporadic inclusion body myositis." University of Western Australia. School of Pathology and Laboratory Medicine, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0153.
Повний текст джерелаSiva, Subramaniam Nitthiya. "An analysis of the Class 1 Gene region in sheep major histocompatibility complex." Thesis, Curtin University, 2012. http://hdl.handle.net/20.500.11937/773.
Повний текст джерелаDicks, Kara Leanne. "Unravelling major histocompatibility complex diversity in the Soay sheep of St Kilda." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31412.
Повний текст джерелаScott, William Reid. "Structures of the human major histocompatibility complex (MHC) class I molecule, HLA B8." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318852.
Повний текст джерелаSherborne, Amy Louise. "Balancing selection at the major histocompatibility complex (MHC) : sequence diversity and inbreeding avoidance." Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501605.
Повний текст джерелаChrisp, Jacqueline Anne. "Studies on the expression of the IL5 gene in T lymphocytes and the structure and expression of the novel MHC gene G1." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260728.
Повний текст джерелаSmith, Kathrine Jane. "Structural analysis of MHC Class I B allele single peptide complexes." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318816.
Повний текст джерелаThorpe, Karen Louise. "Gene structure, phylogeny and mutation analysis of RING3 : a novel MHC-encoded gene." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325009.
Повний текст джерелаAdhikari, Raju. "The role of calnexin, calreticulin and heavy chain glycosylation in MHC class I assembly." Thesis, University of Oxford, 2002. http://ora.ox.ac.uk/objects/uuid:8d626bbd-4927-4a52-b892-461e968a1c96.
Повний текст джерелаVugmeyster, Yulia 1973. "The Major Histocompatibility Complex (MHC) and the proteasome-ubiquitin pathway in T cell development." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/8322.
Повний текст джерелаIncludes bibliographical references.
The essential role of classical MHC molecules in T cell development as well as the proteasome role in antigen processing for MHC-mediated antigen presentation to T cells is well established. However, the contribution of nonclassical MHC molecules, the signals evoked by the MHC-TCR interactions, the signaling role of the proteasome-mediated proteolysis, and the regulation of the proteasome-ubiquitin proteolysis remain to be clarified. Here we address these more subtle but essential aspects of T cell development. We obtained mice deficient for MHC molecules encoded by the H-2K and H-2D genes. KbDb -/- mice have greatly reduced numbers of mature CD8+ T cells, indicating that selection of CD8+ T cells can not be compensated for by [beta]2m-associated molecules other than classical H-2K and D locus products. Spleen cells from KbDb -/- mice generate strong CD8+ MHC class I-specific responses after in vivo priming. Thus, a minor population of CD8+ T cells arises in the complete absence of classical MHC class I molecules. KbDb -/- animals also have self-tolerant natural killer (NK) cells that retain their cytotoxic potential. We utilize a fetal thymic organ culture (FTOC) system with a panel of proteasome inhibitors to implicate the proteasome in thymocyte apoptosis and negative selection. We find that proteasome inhibitors do not completely block but rather delay both dexamethasone- and antigen-triggered thymocyte apoptosis. We also show that proteasome activity is increased in apoptotic thymocytes,
(cont.) as visualized by active site labeling of proteasomal D subunits, indicating that proteasome functions as a positive regulator in thymocyte death cascade. We show that the deubiquitinating enzyme USP7 (HAUSP) is specifically and uniquely processed in apoptotic thymocytes. USP7 protein is highly expressed in thymus, spleen, and brain and is very similar in men and mice. Processing of USP7 does not occur in caspase 3-/- thymocytes but caspase 3 does not cleave USP7 directly. Our results suggest that thymocyte apoptosis leads to a modification of a deubiquitinating enzyme and may provide an additional link between the proteasome-ubiquitin pathway and the caspase cascade during programmed cell death.
by Yulia Vugmeyster.
Ph.D.
Niskanen, A. (Alina). "Selection and genetic diversity in the major histocompatibility complex genes of wolves and dogs." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526205960.
Повний текст джерелаTiivistelmä Isäntä ja taudinaiheuttajat käyvät jatkuvaa kaksinkamppailua, jossa taudinaiheuttajat hyökkäävät ja isäntä puolustautuu. Kamppailussa menestymiseen tarvitaan geneettistä monimuotoisuutta sekä sen pohjalta toimivaa luonnonvalintaa. Pienissä populaatioissa luonnonvalinnan teho voi kuitenkin heikentyä, jolloin immuunipuolustukseen osallistuvat geenit eivät kykene sopeutumaan uusiin tai muuttuneisiin taudinaiheuttajiin. MHC-alueella (major histocompatibility complex) sijaitsee suuri joukko monimuotoisia immuunipuolustukseen osallistuvia geenejä. Väitöskirjassani tutkin luokan II MHC-geeneihin kohdistuvaa luonnonvalintaa ja niiden geneettistä monimuotoisuutta koirilla ja Suomen susilla. Arvioin myös koiran kesyttämisprosessiin osallistuneiden susien määrää nykykoiran MHC-monimuotoisuuden pohjalta. Suomen susipopulaation koko pieneni nopeasti voimakkaan metsästyksen vuoksi 1800-luvun lopulta 1900-luvun alkuun. Populaatio pysyi hyvin pienenä useita vuosikymmeniä, kunnes se alkoi elpyä 1990-luvun puolivälissä. Tutkimus osoitti, että populaatiokoon vaihteluista huolimatta Suomen susien MHC-geenien monimuotoisuus on säilynyt korkeana ja on vastaavalla tasolla kuin Venäjän Karjalan susipopulaatiossa. Suomen ja Venäjän Karjalan susipopulaatioiden MHC-geenit eivät ole erilaistuneet, vaikka populaatiot poikkeavat toisistaan neutraalien geenimerkkien suhteen. Samanlainen tasapainottava valinta näyttäisi kohdistuvan näiden susipopulaatioiden MHC-geeneihin. Keinotekoinen valinta ja eläinlääketieteellinen hoito todennäköisesti heikentävät koirien MHC-geeneihin kohdistuvaa luonnonvalintaa. Luonnonvalinta voisi yhä vaikuttaa alkion- ja sikiönkehityksen aikana, mutta tästä ei tutkimuksessa löytynyt todisteita. MHC-muuntelun määrän arvioitiin olevan suurempaa aasialaisissa kuin eurooppalaisissa koirissa. Simulaatiotutkimuksen mukaan nykyisen koirapopulaation perustamiseen olisi tarvittu vähintään 500 sutta. Tulokset viittaavat koiran kesyttämisen tapahtuneen Aasiassa suuresta ja monimuotoisesta susipopulaatiosta. Sekä luonnonvalinta että demografia vaikuttavat lajien geneettiseen monimuotoisuuteen. Pienissä populaatioissa satunnaisajautuminen voimistuu. Valinta voi kuitenkin olla erityisen voimakasta ja voittaa satunnaisajautumisen geeneissä, joilla on erityisen tärkeä vaikutus yksilön kelpoisuuteen, kuten tutkimuksessa osoitettiin pienen susipopulaation MHC-geenien kohdalla
Qutob, Nouar. "Worldwide MHC class I and II diversity in humans." Thesis, University of Cambridge, 2011. https://www.repository.cam.ac.uk/handle/1810/252242.
Повний текст джерелаMcMillan, Heather Anne. "MHC, parasite burden and heterozygosity in the blue shark (Prionace glauca, L.1758)." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=205227.
Повний текст джерелаBaxter, Rebecca Jayne. "Role of the major histocompatibility complex in immune responsiveness in a Holstein Charolais cattle cross population." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5267.
Повний текст джерелаParasar, Parveen. "Determination of the Expression Patterns of Bovine Non-Classical Major Histocompatibility Complex (MHC) Class I Proteins." DigitalCommons@USU, 2013. http://digitalcommons.usu.edu/etd/1999.
Повний текст джерелаDe, Juan Sanjuan Cristina. "Identification of major histocompatibility complex (MHC) class I chain-related (MIC) and HFE genes in cattle." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434741.
Повний текст джерелаTalken, Beth L. "Assembly of the Lw¹⁶ and Ld class I MHC molecules." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9720532.
Повний текст джерелаSimms, Michelle. "Characterization of the TNFa microsatellite's reliability, MHC associations and occurrence in two ethnically different SLE populations." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0004/MQ42446.pdf.
Повний текст джерелаPersson, Karina. "Structural studies of protein assemblies : MHC class I and lumazine synthase /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5499-9.pdf.
Повний текст джерелаSivaganesh, Sivasuriya. "Recipient DCs presenting intact and processed MHC alloantigen mediate CD8⁸ T-cell responses." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609327.
Повний текст джерелаMeyer-Lucht, Yvonne. "Does variability matter? Major histocompatibility complex (MHC) variation and its associations to parasitism in natural small mammal populations." Phd thesis, Universität Potsdam, 2009. http://opus.kobv.de/ubp/volltexte/2009/3641/.
Повний текст джерелаIn einer sich ständig verändernden Umwelt ist es unverzichtbar, sich fortwährend zu verändern und anzupassen. Dabei gründet sich das Anpassungsvermögen oder das evolutionäre Potential einer Art auf ihre genetische Variabilität. In der Krankheitsabwehr ist die Variabilität der Immungene ein besonders wichtiges und effektives Instrument, weil Pathogene sehr vielfältig sind und schnell evolvieren. Im Rahmen meiner Doktorarbeit habe ich mich mit der Variabilität des Immungen-Komplexes MHC (major histocompatibility complex) beschäftigt, der eine Schlüsselrolle in der Immunabwehr bei Vertebraten einnimmt. Anhand verschiedener Arten und Populationen von Kleinsäugern habe ich den Einfluss der MHC Vielfalt auf den Parasitenbefall unter natürlichen Bedingungen untersucht. Dabei interessierte mich insbesondere das Vorkommen geringer MHC Variabilität in Populationen, das möglicherweise eine Folge von Lebensraum-fragmentierung und Isolation ist. Obwohl Beuteltiere eine zentrale Rolle in der Evolution der Säugetiere spielen, ist über ihren MHC bislang nur sehr wenig bekannt. Einige Studien befassten sich mit Labor- oder Zootieren, und deuteten auf geringe oder sogar gar keine Variation im MHC Klasse II bei Beuteltieren hin. Allerdings gab es bislang nahezu keine Studien an frei lebenden Beuteltieren, deshalb war bislang ein natürliches Ausmaß der MHC Variabilität unbekannt. Anhand von zwei endemischen neotropischen Beuteltieren aus dem brasilianischen Küstenregenwald (Gracilinanus microtarsus, Marmosops incanus) habe ich überprüft, ob sich diese geringe MHC Vielfalt unter natürlichen Freilandbedingungen bestätigt. Erstmals konnte ich zeigen, dass der MHC II bei Beuteltieren charakteristische Merkmale positiver Selektion aufweist, die bisher nur von placentalen Säugern, Vögeln und Fischen bekannt waren: Positive Selektion auf spezifischen Aminosäurepositionen, Rekombination und Trans-Species-Polymorphismus. Darüber hinaus unterschieden sich die beiden Beuteltierarten beträchtlich in ihrer MHC II Variabilität. Während M. incanus sich als relativ wenig divers erwies, zeigte G. microtarsus eine zehnmal höhere Vielfalt und widerlegt damit die generelle Gültigkeit der ursprünglich angenommenen geringen MHC II Variabilität bei Beuteltieren. Um diese beachtlichen Diversitätsunterschiede zwischen den beiden Arten zu erklären, habe ich die Parasitenbelastung untersucht. Bei beiden Arten konnte ich nachweisen, dass bestimmte MHC Varianten mit entweder hoher oder niedriger Parasitenbelastung verknüpft waren. Solche Assoziationen spiegeln Pathogen-vermittelte Selektion wider, untermauern die Funktionalität des MHC Klasse II bei Beuteltieren und weisen auf dieselbe Bedeutsamkeit des MHC wie bei placentalen Säuger, Vögeln und Fischen hin. Ich entwickelte zwei alternative evolutionäre Szenarien, unter denen eine geringe MHC Variabilität denkbar ist. Im Szenario des ‘evolutionären Gleichgewichts’ ist geringe MHC Variabilität die Folge eines verminderten Selektionsdruckes durch wenige Parasiten, sodass eine geringe Parasitendiversität zu erwarten ist. Alternativ könnte eine geringe MHC Variabilität aber auch Folge eines kürzlich erlittenen Verlustes an genetischer Variabilität sein, beispielsweise durch ein Flaschenhalsereignis. Unter diesem Szenario des ‘Ungleichgewichts’ wäre bei M. incanus im Falle eines potentiellen Verlustes von Resistenzallelen eine starke Parasitenbelastung zu erwarten. Die parasitologischen Ergebnisse widersprechen dem ersten und deuten eher auf das zweite Szenario. M. incanus war deutlich stärker parasitiert als G. microtarsus, wohingegen die Parasitendiversität bei beiden Arten ungefähr gleich war. Die hohe Parasitenbelastung bei M. incanus ist offenbar weniger der Auslöser als vielmehr eine Folge seiner geringen MHC Vielfalt zu sein. Üblicherweise werden sowohl die Variabilität des MHC als auch seine Verknüpfung mit Parasitenbelastung innerhalb von einzelnen Populationen untersucht, nur selten wird die Variation zwischen Populationen in Betracht gezogen. Um Erkenntnisse auf dieser Ebene zu gewinnen, habe ich den Zusammenhang zwischen genetischer Vielfalt und Parasitenbelastung nicht auf der Ebene des Individuums, sondern auf der Populationsebene anhand der europäischen Gelbhalsmaus (Apodemus flavicollis) erforscht. Dabei wurden Populationen mit unterschiedlicher genetischer Variabilität am MHC und an neutralen genetischen Markern (Mikrosatelliten) betrachtet. Ich konnte nachweisen, dass Populationen, die über ein großes Spektrum verschiedener MHC Allele verfügen, besser gegen starke Parasitenbelastung gewappnet sind als Populationen mit einer geringen Anzahl MHC Allele. In einer MHC-diversen Population ist die Gegenwart von Individuen mit Resistenzallelen deutlich wahrscheinlicher, und damit die Überlebenswahrscheinlichkeit der Population. Diese Ergebnisse erweitern und vertiefen unsere Erkenntnisse zu die komplexen evolutionären Vorgängen und Mechanismen zwischen Wirt und Parasit in ihrem fortwährenden Wettstreit.
Shoukry, Mohamed Naglaa. "Study of the cellular factors affecting presentation of retroviral superantigens by Major Histocompatibility Complex (MHC) class II molecules." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0030/NQ64669.pdf.
Повний текст джерелаLyons, Amanda C. "Characterization of major histocompatibility complex class I loci of the lark sparrow (Chondestes grammacus) and insights into avian MHC evolution." Bowling Green State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1383578046.
Повний текст джерелаFlorence, William Clinton. "Increased stability of class II MHC-peptide complexes in macrophages infected with mycobacterium avium and the examination of a novel role for cathepsin L in the innate immune response to Francisella Novicida infection." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1173298339.
Повний текст джерелаBrimpari, Minodora. "Regulation of MHC class I and II expression in mouse Epiblast stem cells." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609719.
Повний текст джерелаSepil, Irem. "The secret in their MHC : variation and selection in a free living population of great tits." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:dd753cf0-9ec5-4d63-b318-57f037d73ee5.
Повний текст джерелаStrand, Tanja. "European Black Grouse : MHC Genetic Diversity and Population Structure." Doctoral thesis, Uppsala universitet, Populationsbiologi och naturvårdsbiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160042.
Повний текст джерелаRussell, Ratanasuda Roslin. "The Major Histocompatibility Complex (MHC) gene expression in health and disease : the application of different technologies for gene expression profiling." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615647.
Повний текст джерелаSumners, Lindsay Hart. "Immunological Response to Clostridium perfringens in Two Genetically Divergent Lines of Chickens as Influenced by Major Histocompatibility Complex (MHC) Genotype." Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/43370.
Повний текст джерелаMaster of Science
Ferrandiz-Rovira, Mariona. "The role of the major histocompatibility complex in the wild : the case of the Alpine marmot (Marmota marmota)." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10089/document.
Повний текст джерелаIntra-specific genetic diversity represents the true potential of adaptation of species and is thus essential for evolutionary change. In vertebrates, the genes of the major histocompatibility complex (MHC) play a critical role in vertebrate disease resistance by initiating immune response. The selective pressure carried out by parasites and sexual selection via mate choice are supposed to maintain the extreme diversity found in the MHC. Yet, empirical differentiation of selective pressures acting on MHC in the wild requires individually based monitoring of a large number of individuals and genotyping them. The aim of this thesis was firstly to develop and apply a genotyping protocol in Alpine marmots (Marmota marmota) to genotype four previously described MHC loci. This allows subsequently to evaluate, in a wild population of Alpine marmots, if MHC characteristics play a role (1) on mate choice, (2) on the presence and/or abundance of three intestinal parasite species and (3) on juvenile survival. This work provided a suitable method to reliably genotype large number of individuals using next-generation sequencing techniques. Then, we found evidences for female mate choice based on MHC but also on neutral genetic characteristics. Subsequently, we evidenced the weak role of MHC characteristics on the presence and abundance of three intestinal parasites. Finally, we found evidences for a change of the effect of genetic diversity at both MHC and neutral loci on juvenile survival during the 23-year monitoring study. Overall, this thesis comprises an integrated approach for the study of the roles of MHC in a contemporaneous population of Alpine marmots
Gersch, Jeffrey Walter. "Microsatellite, mitochondrial, and major histocompatibility complex analyses of genetic structure in the nurse shark, Ginglymostoma cirratum, in the western Atlantic Ocean." OpenSIUC, 2012. https://opensiuc.lib.siu.edu/theses/936.
Повний текст джерелаChilders, Christopher P. "Sequence assembly and annotation of the bovine major histocompatibility complex (BoLA) class IIb region, and in silico detection of sequence polymorphisms in BoLA IIb." Texas A&M University, 2006. http://hdl.handle.net/1969.1/4821.
Повний текст джерелаRodino, Kyle G. "Orientia tsutsugamushi Modulates Endoplasmic Reticulum Stress to Benefit its Intracellular Growth and Targets NLRC5 to Inhibit Major Histocompatibility Complex I Expression." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5264.
Повний текст джерелаMolano, Alberto. "Peptide binding, TCR recognition and intrathymic positive selection : by an MHC H-2Kb class I molecule devoid of the central anchor ("c") pocket /." Access full-text from WCMC, 1998. http://proquest.umi.com/pqdweb?did=733066101&sid=11&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Повний текст джерелаAllen, Abigail E. "The Effects of a Set of Novel Compounds on Interferon-gamma Induced Major Histocompatibility Complex (MHC) Class II Molecules in Cultured Thyroid Cells." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1534199427178941.
Повний текст джерелаYang, Tianyu. "Two novel mechanisms of MHC class I down-regulation in human cancer accelerated degradation of TAP-1 mRNA and disruption of TAP-1 protein function /." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1078192113.
Повний текст джерелаTitle from first page of PDF file. Document formatted into pages; contains x, 117 p.; also includes graphics (some col.) Includes bibliographical references (p. 99-117). Available online via OhioLINK's ETD Center