Добірка наукової літератури з теми "Macromolecular crowding agents"
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Статті в журналах з теми "Macromolecular crowding agents"
De Pieri, Andrea, Shubhasmin Rana, Stefanie Korntner, and Dimitrios I. Zeugolis. "Seaweed polysaccharides as macromolecular crowding agents." International Journal of Biological Macromolecules 164 (December 2020): 434–46. http://dx.doi.org/10.1016/j.ijbiomac.2020.07.087.
Повний текст джерелаLee, Hong Bok, Anh Cong, Hannah Leopold, Megan Currie, Arnold J. Boersma, Erin D. Sheets, and Ahmed A. Heikal. "Rotational and translational diffusion of size-dependent fluorescent probes in homogeneous and heterogeneous environments." Physical Chemistry Chemical Physics 20, no. 37 (2018): 24045–57. http://dx.doi.org/10.1039/c8cp03873b.
Повний текст джерелаStepanenko, Olesya V., Olga V. Stepanenko, Irina M. Kuznetsova, and Konstantin K. Turoverov. "The unfolding of iRFP713 in a crowded milieu." PeerJ 7 (April 8, 2019): e6707. http://dx.doi.org/10.7717/peerj.6707.
Повний текст джерелаdel Álamo, Marta, Germán Rivas, and Mauricio G. Mateu. "Effect of Macromolecular Crowding Agents on Human Immunodeficiency Virus Type 1 Capsid Protein Assembly In Vitro." Journal of Virology 79, no. 22 (November 15, 2005): 14271–81. http://dx.doi.org/10.1128/jvi.79.22.14271-14281.2005.
Повний текст джерелаGnutt, David, and Simon Ebbinghaus. "The macromolecular crowding effect – from in vitro into the cell." Biological Chemistry 397, no. 1 (January 1, 2016): 37–44. http://dx.doi.org/10.1515/hsz-2015-0161.
Повний текст джерелаVweza, Alick-O., Chul-Gyu Song, and Kil-To Chong. "Liquid–Liquid Phase Separation in the Presence of Macromolecular Crowding and State-Dependent Kinetics." International Journal of Molecular Sciences 22, no. 13 (June 22, 2021): 6675. http://dx.doi.org/10.3390/ijms22136675.
Повний текст джерелаZhou, Huan-Xiang. "Effect of mixed macromolecular crowding agents on protein folding." Proteins: Structure, Function, and Bioinformatics 72, no. 4 (May 27, 2008): 1109–13. http://dx.doi.org/10.1002/prot.22111.
Повний текст джерелаBiswas, Saikat, and Pramit K. Chowdhury. "Unusual domain movement in a multidomain protein in the presence of macromolecular crowders." Physical Chemistry Chemical Physics 17, no. 30 (2015): 19820–33. http://dx.doi.org/10.1039/c5cp02674a.
Повний текст джерелаZhang, Chen, Fang Li, Si-Xi Wang, Zhao-Sheng Liu, and Haji Akber Aisa. "Molecularly imprinted polymers prepared using a porogenic solvent of an ionic liquid and a macromolecular crowding agent and their application in purification of oleanic acid." Analytical Methods 7, no. 24 (2015): 10256–65. http://dx.doi.org/10.1039/c5ay01960e.
Повний текст джерелаKoch, Leon, Roland Pollak, Simon Ebbinghaus, and Klaus Huber. "A Comparative Study on Cyanine Dyestuffs as Sensor Candidates for Macromolecular Crowding In Vitro and In Vivo." Biosensors 13, no. 7 (July 8, 2023): 720. http://dx.doi.org/10.3390/bios13070720.
Повний текст джерелаДисертації з теми "Macromolecular crowding agents"
Cooper, Elisa. "[alpha]-synuclein oligomer formation and the effect of macromolecular crowding agents on fibrillation /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2005. http://uclibs.org/PID/11984.
Повний текст джерелаKundu, Jayanta. "Study of heme proteins in presence of macromolecular crowding agents." Thesis, 2017. http://localhost:8080/iit/handle/2074/7458.
Повний текст джерелаHsu, Yun-Hsiang, and 許雲翔. "The effect of hydrophilicity on macromolecular crowding in paramagnetic solution of magnetic resonance imaging contrast agent." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/13025929986776183900.
Повний текст джерела國立中山大學
化學系研究所
102
The power of MRI is tremendously enhanced by the application of various types of MRI contrast agents which increase the relaxivity of water molecules close to them through strong dipolar interactions between water and the paramagnetic ions on the contrast agent. With about 30 years of advancement, MRI contrast agents with various functions, such as signal enhancement, target selection and molecular or event specificity, have been developed. More MRI contrast agents with different purposes are under development today. To better understand the mechanism of MRI contrast agents in various conditions and to develop new generation MRI contrast agents, it is desired that the interactions between the MRI contrast agents and other molecules in their proximity are better understood. We have found that macromolecular crowding effect is an important contributing factor that affects the performance of MRI contrast agents. Therefore, we have decided to carry out a full investigation of this phenomenon with different crowding molecules and MRI contrast agents. This work will report the results with sodium polyacrylate (NaPA) as crowder and Dotarem as MRI contrast agent and focus on the hydrophiliity of macromolecules. A linear relationship is found between the concentration of Dotarem and relaxation rates and chemical shift. A nonlinear relationship is found between the concentration of NaPA and relaxation rates and chemical shift. The hydrophilicity of macromolecular crowders has significant influence on overall crowding effect. The simple picture of volume exclusion must be updated and intermolecular interactions must be taken into account. Morevoer, the details of the crowding effect of NaPA and that of PEG are compared and discussed.
Hsin, Yu-Chun, and 忻佑純. "The Crowding Effect of Ficoll 70 on Magnetic Resonance Imaging Contrast Agent Dotarem and Comparison with Other Macromolecular Crowders." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/27473276712915148733.
Повний текст джерела國立中山大學
化學系研究所
102
Owing to its many advantages such as noninvasiveness and its ability for providing multiple layers of information on structure and dynamics, magnetic resonance imaging (MRI) has become an essential clinical equipment but also a powerful tool for basic research in various fields. By using MRI contrast agents, more specificity and selectivity can be achieved with MRI, which has prompted the development of thousands of MRI contrast agents over the past decades. The performance of the MRI contrast agent depends on their chemical structure and the interaction with the other molecules around them such as water. The basic principle of MRI contrast agents is to increase water relaxation with paramagnetic ions. The performance of an MRI contrast agent depends not only on the structure and dynamics of the compound, but also on the environment it is located. In a typical living system, there are lots of macromolecules such as proteins, lipids, sugars, nucleic acids, ribosomes etc, making cell a highly crowded environment. To obtain insight into the influence of water motions by Dotarem under the crowded conditions, we use three types of crowding agent (Ficoll 70、NaPA、PEG6000). Ficoll 70 (70 kDa) is a synthetic crowding agent and a cross-linked sucrose polymer. NaPA and PEG6000 are linear structural polymers. We used nuclear magnetic resonance spectroscopy (NMR) to measure the longitudinal relaxation rate (R1), transverse relaxation rate (R2), translational diffusion, MRI and NMRD (Nuclear Magnetic Relaxation Dispersion) under different concentrations of crowders and contrast agent. We have found that macromolecular crowding effect is an important contributing factor that affects the performance of MRI contrast agents. The details of the crowding effect of different crowding agents are compared and discussed. The results demonstrate the significant effect of crowders on the relaxivity of MRI contrast agent and indicate that a molecular level understanding of the relaxtion mechanism of MRI contrast agent in a crowded environment helps establishment of a microscopic picture of MRI contrast generation and prevents mistakes in diagnosis in medical MRI.
Chen, Shou-fu, and 陳碩甫. "NMR diffusion and relaxation reveal significant ionic influence and macromolecular crowding effect on the performance of magnetic resonance imaging contrast agent." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/11265763746210448015.
Повний текст джерела國立中山大學
化學系研究所
104
Magnetic resonance imaging (MRI) has become the most important non-invasive method for providing three dimensional detailed images without using damaging radiation and is a powerful tool in materials science, biomedicine, medical diagnosis, food science and many other fields. In many situations such as in disease detection, however, the image contrast is not sufficient. Therefore, through the MRI contrast agent, its high paramagnetic ion can effectively and selectively accelerate water 1H nuclear relaxation rates. Therefore, water molecules in different microenvironments obtain a different relaxation acceleration so that a better contrast is achieved for the diseased regions. However, current theory for MRI contrast agent was developed by assuming that the paramagnetic ions are located in a dilute aqueous solution. This is a good approximation in many situations such as water in a relatively free microenvironments, but cellular environment is highly crowded with various kinds of biomacromolecules (proteins, hydrocarbonates, genetic materials etc), small molecules (hormones, vitamins etc) and ions (H+, Na+, K+, Cl- etc). The performance of MRI contrast agent may be significantly altered by crowders and ions. Understanding how the contrast agent interacts with other molecules in cell is a very important and challenging problem. In this work, we focus on the influence of common ions in organisms and macromolecular crowding effect on the performance of MRI contrast agent. The MRI contrast agent we chose is Dotarem which is the mostly used in medical diagnosis.. Then we follow the standard practice of selecting a macromolecular crowder (polyethylene glycol, M.W. 6000, PEG6k, an artificial inert macromolecule, with no specific structure in aqueous solutions) to mimic cellular environment. The ions used here are those mostly commonly found in humans (LiCl, NaCl, KCl, MgCl2, CaCl2, NaI). 1H NMR relaxation rates and translational diffusion rate of water and PEG6k are measured on a 500 MHz NMR spectrometer equipped with a Pulse Filed Gradient (PFG) unit. It is found that the longitudinal relaxation rates and translational diffusion coefficient are sensitive measures for quantifying the effects of ions and macromolecular crowders on the performance of MRI contrast agent. Within the concentration range typically present in an organism, these dynamic parameters are found to clearly depend on the concentration, type and valence number of the ions besides the concentration of MRI contrast agent and macromolecular crowding effect. These results are further supplemented by fast field cycling relaxometry (NMR relaxation dispersion) over a range between 0.01 – 40 MHz. The physical chemistry mechanism of these effects is elucidated by analyzing the experimental results. The significance of these effects to practical MRI is discussed. Based on the experimental and theoretical results as well as the analysis, we conclude that both the ionic and macromolecular effects must be taken into account for more precise MRI diagnosis or functional MRI studies.
Частини книг з теми "Macromolecular crowding agents"
Reddy, Michael K., Stephen E. Weitzel, Shirley S. Daube, Thale C. Jarvis, and Peter H. von Hippel. "[36] Using macromolecular crowding agents to identify weak interactions within DNA replication complexes." In Methods in Enzymology, 466–76. Elsevier, 1995. http://dx.doi.org/10.1016/0076-6879(95)62038-9.
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