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Статті в журналах з теми "Ma ying long"
1
Wiratama, Daniel Tantra. "The Golden Age of China-Taiwan Relations: The Explanation and Its Future." Jurnal Sentris 1, no. 1 (August 17, 2020): 69–80. http://dx.doi.org/10.26593/sentris.v1i1.4130.69-80.
Повний текст джерелаАнотація:
The past eight years since 2008 under the leadership of Ma Ying-jeou, the relations between China and Taiwan have been experiencing the golden age. By cooperating in many sectors, like economic partnership; social interactions; tourism and some political dialogues, both countries have been building a good relationship between them. Looking back to the past, China and Taiwan have a long series of conflicts, which ended in the Chinese Civil War 1949 with the victory of the Chinese Communist party which has now become the People’s Republic of China. Meanwhile, its opposing democratic party has now become the Republic of China (Taiwan). Since then, China and Taiwan’s relations have been on a standstill Ma Yingjeou rose to power as the president of Taiwan. By using the concept of Economic Interdependence and Conflict in World Politics by Mark J.C. Crescenzi, this paper aims to explain how the golden age of China-Taiwan relations have been going on in the past eight years up until now, as well as the future of the relations itself under the new president of Taiwan, Tsai Ing-we. This paper has the following research question: how has the good relation between China and Taiwan been built since 2008, considering their previously severed relations in the past?
2
Li, Qing-Jie, Xue-Liang Fang, Ying-Qin Li, Jia-Yi Lin, Cheng-Long Huang, Shi-Wei He, Sheng-Yan Huang, et al. "Abstract 1999: DCAF7 acts as a scaffold to recruit USP10 for G3BP1 deubiquitylation and facilitates chemoresistance and metastasis in nasopharyngeal carcinoma." Cancer Research 84, no. 6_Supplement (March 22, 2024): 1999. http://dx.doi.org/10.1158/1538-7445.am2024-1999.
Повний текст джерелаАнотація:
Abstract Though docetaxel plus cisplatin and 5-fluorouracil (TPF) induction chemotherapy becomes the standard care for locoregionally advanced nasopharyngeal carcinoma (NPC), some patients could not benefit from this therapy. The underlying mechanisms remain unclear. We found that DCAF7 was highly expressed in TPF resistant NPC patients, and promoted the cisplatin resistance and metastasis of NPC cells. Mechanistically, DCAF7 facilitates the interaction between USP10 and G3BP1, resulting in the removal of K48-linked ubiquitylation of G3BP1 at Lys76 mediated by USP10, thus preventing the degradation of G3BP1 through ubiquitin-proteasome pathway, and facilitates the stress granule (SG)-like structures formation. Moreover, knockdown of G3BP1 successfully reversed the SG-like structures formation and oncogenic effects exerted by DCAF7. Importantly, NPC patients with elevated DCAF7 expression exhibited high risks of metastasis, and is associated with a poor prognosis. This study identifies DCAF7 as a pivotal cisplatin resistance gene, and sheds light on the underlying mechanism of TPF resistance in NPC patients. The DCAF7-USP10-G3BP1 axis provides potential therapeutic targets and biomarker for NPC treatment. Citation Format: Qing-Jie Li, Xue-Liang Fang, Ying-Qin Li, Jia-Yi Lin, Cheng-Long Huang, Shi-Wei He, Sheng-Yan Huang, Jun-Yan Li, Sha Gong, Kai-Lin Chen, Na Liu, Jun Ma, Yin Zhao, Ling-Long Tang. DCAF7 acts as a scaffold to recruit USP10 for G3BP1 deubiquitylation and facilitates chemoresistance and metastasis in nasopharyngeal carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1999.
3
Yang, Xiangcai, Yan Dai, Qinglin Ding, Feng Du, Jinhua Li, Chuhe Liu, Chunyang Lv, et al. "Abstract 6053: Mechanism of action of tumor-selective, chaperone-mediated protein degraders (CHAMPs)." Cancer Research 84, no. 6_Supplement (March 22, 2024): 6053. http://dx.doi.org/10.1158/1538-7445.am2024-6053.
Повний текст джерелаАнотація:
Abstract HSP90 mediates the folding of many important cancer-associated proteins, but it can also direct its substrates towards degradation via the ubiquitin-proteasome system. Furthermore, in tumor tissues, HSP90 complexes are in an activated state relative to normal tissues, and small molecule HSP90 inhibitors display unique tumor-selective pharmacokinetics. To take advantage of these attributes, we have developed a novel targeted protein degradation technology, termed Chaperone-Mediated Protein Degradation (CHAMP), and present here an in-depth characterization of the CHAMP mechanism of action. Initially, from a chemical library of greater than 1000 linkered HSP90 binders, hetero-bifunctional CHAMPs were synthesized in which target protein binders and HSP90 binders were covalently coupled together by short linkers. The resulting compounds were screened for target protein degradation and cancer cell cytotoxicity to identify promising leads for further optimization. We found that CHAMPs can degrade a wide variety of target proteins. This included proteins that are known to be regulated by HSP90, such as transcription factor BRD4 or ERK5 kinase. However, proteins that are normally independent of HSP90 function can also be degraded, including mutated KRAS and SHP2 phosphatase. In vitro, CHAMP treatment of cells resulted in formation of a ternary complex between the target protein, CHAMP compound and HSP90. Moreover, an X-ray crystal structure was solved for a mKRAS-CHAMP-HSP90 ternary complex. CHAMP-mediated degradation required both the target- and HSP90-binding moieties to be covalently coupled and involved ubiquitination of the target protein. Multiple ubiquitin E3 ligases were present in ternary complexes, and depending on the target protein, NEDD8 inhibition or CRISPR knockouts of individual E3 ligases could suppress proteasome-dependent target degradation. In vivo, irrespective of target, CHAMPs displayed prolonged exposure in tumors relative to plasma and normal tissues, resulting in prolonged target degradation in tumors and strong tumor growth inhibition at well-tolerated doses. CHAMP technology can be applied to a diversity of cancer-associated targets and has potential advantages relative to other protein degradation approaches, including an improved safety margin due to preferential accumulation in tumor tissues. Citation Format: Xiangcai Yang, Yan Dai, Qinglin Ding, Feng Du, Jinhua Li, Chuhe Liu, Chunyang Lv, Liang Ma, Thomas L. Prince, Yuetong Sun, Mingkai Wang, Rong Wang, Yaya Wang, Zhiyong Wang, Min Wu, Mengmeng Xu, Zimo Yang, Long Ye, Wei Yin, Chenghao Ying, Haoxin Zhou, Guoqiang Wang, Weiwen Ying, Kevin P. Foley. Mechanism of action of tumor-selective, chaperone-mediated protein degraders (CHAMPs) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6053.
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Pulido, Ines, Qiyue Luan, Chenghao Yin, Zimo Yang, Jinhua Lin, Yaya Wang, Yuetong Sun, et al. "Abstract B093: Treating KRAS(G12D) inhibitor resistance using a KRAS- and HSP90 chaperone-targeted hetero-bispecific small molecule agent." Molecular Cancer Therapeutics 22, no. 12_Supplement (December 1, 2023): B093. http://dx.doi.org/10.1158/1535-7163.targ-23-b093.
Повний текст джерелаАнотація:
Abstract KRAS is the most frequently mutated oncoprotein in human cancers. Although long considered “undruggable”, recent breakthroughs in medicinal chemistry have led to FDA-approval of the KRAS(G12C) mutation-specific inhibitors sotorasib and adagrasib for the treatment of KRAS(G12C)-positive non-small cell lung cancer. However, illustrating the need to develop additional novel agents targeting mutated KRAS, the 5-year relative survival rate for pancreatic cancer, which is commonly associated with a variety of different KRAS mutations, is only 12% (all SEER stages) due to poor early detection and a lack of effective treatments. In particular, KRAS(G12D) is the most common KRAS mutation, being found in 37% of pancreatic ductal adenocarcinomas (PDACs), as well as in 12.5% of colorectal cancer and 4.9% of lung adenocarcinoma (LUAD) patients. MRTX1133 is a highly-selective, non-covalent KRAS(G12D) inhibitor that has recently entered a phase 1 clinical trial. However, here we show that exposure of KRAS(G12D)-mutated PDAC (PANC-1 and AsPC-1) and LUAD (SK-LU-1) cell lines and a patient-derived organoid (PDO) PDAC model (RPAN001) to MRTX1133 resulted in varying degrees of in vitro efficacy. Decreased downstream KRAS signaling in the form of reduced phospho-ERK1/2 levels was observed to rapidly recover within 24 hours of treatment with 500 nM MRTX1133. Moreover, this rebound coincided with increased expression of KRAS, NRAS andHRAS mRNAs. Concurrently, activation of the receptor tyrosine kinases (RTKs) EGFR and MET was observed in PANC-1 and SK-LU-1 cells that displayed innate resistance to MRTX1133, while the sensitive AsPC-1 cells showed no such RTK activation. These results suggest that targeting of both KRAS(G12D) and RTKs may be needed to treat KRAS(G12D) inhibitor-resistant cancers. To address this, we employed a novel hetero-bispecific CHAMP molecule, RNK08179, that simultaneously targets both KRAS(G12D) and HSP90, an RTK-regulating chaperone protein. RNK08179 treatment demonstrated a striking reduction in phospho-ERK1/2 levels, RTK activation and cell viability in MRTX1133-resistant PANC-1 and SK-LU-1 cells. Furthermore, similar efficacy was observed in the MRTX1133-resistant RPAN001 PDO model. In summary, RNK08179 displayed promising efficacy in cancer models harboring KRAS(G12D) by suppressing both mutated KRAS and HSP90-supported RTK signaling. Citation Format: Ines Pulido, Qiyue Luan, Chenghao Yin, Zimo Yang, Jinhua Lin, Yaya Wang, Yuetong Sun, Chuche Liu, Haoxin Zhou, Marek Massad, Ian Papautsky, Thomas L. Prince, Guoqiang Wang, Kevin P. Foley, Weiwen Ying, Takeshi Shimamura. Treating KRAS(G12D) inhibitor resistance using a KRAS- and HSP90 chaperone-targeted hetero-bispecific small molecule agent [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2023 Oct 11-15; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2023;22(12 Suppl):Abstract nr B093.
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Schmidt, Stephanie T., Ying Zhu, Li Zhao, Chunjie Jiang, Patrizio Di Micco, Costas Mitsopoulos, Andrew Futreal, and Bissan Al-Lazikani. "Abstract C059: Probabilistic graph-based model uncovers druggable vulnerabilities in major solid cancers." Molecular Cancer Therapeutics 22, no. 12_Supplement (December 1, 2023): C059. http://dx.doi.org/10.1158/1535-7163.targ-23-c059.
Повний текст джерелаАнотація:
Abstract We present A3D3a’s Molecular Vulnerability Picker (MVP), a novel probabilistic approach to determine vulnerabilities in networks of cancer interactions for the identification of new therapeutic targets. Successes in targeted therapies driven by molecular profiling have helped 47% of cancer patients achieve long-lasting remission. However, over half of patients still lack safe, effective, and long-lasting treatment options. Successes have often clustered around exploitation of major driver mechanisms that can be clearly discerned from molecular data. Heterogeneity, rarity, and complexity of these remaining cancers mean that the signal of key molecular vulnerabilities, i.e., protein targets that can be exploited for therapy, can be drowned out by noise. We developed A3D3a’s MVP to increase the signal-to-noise ratio in cancer networks of interaction and alteration information to determine vulnerabilities toward the identification of new potential drug targets. To implement A3D3a’s MVP, we constructed protein networks of major solid cancers from TCGA data that we used as a framework for information flow. We developed a novel weight-biased Markov Chain model to highlight cooperativity of weak signals arising from related regions of the protein network, emphasizing previously hidden signal within these cancer networks. To validate A3D3a’s MVP, we examined the top genes it returned in the Dependency Map and the Genomics of Drug Sensitivity in Cancer. We further validated our findings by comparing the number of genetic dependencies and drug targets recovered by the model to that recovered by the state of the art. Finally, we applied A3D3a’s MVP to identify therapeutic opportunities across cancer indications and extended our analysis to highlight well-ranked genes whose proteins contain druggable pockets and thus, could serve as new drug targets. For the 19 cancer types included in this analysis, A3D3a’s MVP returned significantly more genetic dependencies (p < 0.01) and drug targets (p < 0.001) than genes ranked by the state of the art. We demonstrate that A3D3a’s MVP is able to increase the signal of weakly altered genes and is also able to identify genuine dependencies that themselves are not mutated or altered in any way. Using A3D3a’s MVP, we identified 56 drug repurposing opportunities and 49 potential druggable targets for solid cancers and also highlight novel potential druggable targets for future exploitation and new therapeutics. In summary, A3D3a’s MVP is a novel mathematical modeling approach that increases the signal-to-noise ratio in cancer molecular data and helps uncover previously hidden molecular vulnerabilities towards new potential drug targets to address unmet patient needs. Citation Format: Stephanie T Schmidt, Ying Zhu, Li Zhao, Chunjie Jiang, Patrizio Di Micco, Costas Mitsopoulos, Andrew Futreal, Bissan Al-Lazikani. Probabilistic graph-based model uncovers druggable vulnerabilities in major solid cancers [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2023 Oct 11-15; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2023;22(12 Suppl):Abstract nr C059.
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Kyaing, May Sandar, San Thandar, Moe Moe Myint, Khaing Phyo Wai, Honey Thet Paing Htwe, Chan Myae Nyein, Jeung-Sul Han, and Aung Htay Naing. "Characterization of Fruit Quality Traits and Biochemical Properties in Different Myanmar Mango Cultivars during Ripening Stages." International Journal of Plant Biology 14, no. 1 (December 22, 2022): 14–27. http://dx.doi.org/10.3390/ijpb14010002.
Повний текст джерелаАнотація:
Here, we characterized the changes in fruit quality and biochemical parameters in four Myanmar mango cultivars from ripening stage 1 to 4 at ambient temperature. Total soluble solids, total sugars, and reducing and non-reducing sugar content increased, whereas titratable acidity decreased with increasing storage time in all cultivars. ‘Sein Ta Lone’ showed the highest consumer acceptability, with maximum sensory quality scores owing to its unique characteristics. ‘Hin Thar’ and ‘Ma Chit Su’ also had better quality and sensory attributes than ‘Yin Kwae’. Sugar/acid ratios in all cultivars ranged from 23 to 50, the standard sugar/acid ratios in high-quality mango fruits. The total phenolic content (TPC) and antioxidant activity among cultivars ranged from 8.20 to 14.96 mg gallic acid equivalents and 19.52 to 26.79 mg vitamin C equivalents antioxidant capacity, respectively, per 100 g of fruit extract throughout the storage. ‘Hin Thar’ was the richest in phytochemical compounds. A significant positive correlation was found between total phenolic activity and 2,2-diphenyl-1-picryl-hydrazyl free radical scavenging activity of fruits, showing that TPC exhibited linear relationships with the antioxidant activities of each mango variety during the different stages of ripening.
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Chan, Michael W. Y., Yin-Chen Chen, Ching-Wen Lin, Frank Cheng, Ching-Cher Sanders Yan, Chao-Ping Hsu, Yu-Min Chuang, et al. "Abstract 97: A E2F6 ceRNA network suppresses dendritic cell function, via PBX1/IL-10 signaling, in ovarian cancer." Cancer Research 84, no. 6_Supplement (March 22, 2024): 97. http://dx.doi.org/10.1158/1538-7445.am2024-97.
Повний текст джерелаАнотація:
Abstract It is reported that long-term use of estrogen could increase the risk of ovarian cancer. However, the role of estrogen in immunoevasion is not fully explored. We have previously demonstrated that estrogen-mediated upregulation of E2F6, and, c-Kit, by epigenetic silencing of miR-193a, and a competing endogenous (ceRNA) mechanism. In this study, we found that PBX1, a transcriptional activator of the immunosuppressive cytokine, IL-10, is also a target of miR-193a. Importantly, overexpression of the E2F6 3’UTR upregulates both E2F6 and, PBX1, as well as IL10 in ovarian cancer cell lines, suggesting that ceRNA mechanism exists between E2F6 and PBX1. These phenomena are further supported by our stochastic simulation of the estrogen-mediated E2F6 ceRNA network on the distribution of E2F6 and PBX1 mRNA in cancer cells, which is consistent with the TCGA ovarian cancer RNA-Seq dataset. Importantly, monocyte-derived dendritic cell activation of T-cell function was inhibited by pretreatment of conditioned media derived from ovarian cancer cells overexpressing E2F6 3’UTR; such inhibition was rescueable by an anti-IL-10 antibody. Clinically, IL10 level was higher in ovarian cancer patients with higher E2F6 and PBX1, and in ovarian cancer cell lines overexpressed with E2F6 3’UTR. Taken together, these results showed that E2F6 could suppress anti-tumor immune response of dendritic cell, E2F6 ceRNA network. Epigenetic intervention in restoring the expression of miR-193a may be able to enhance anti-tumor immune response against ovarian cancer. Citation Format: Michael W.Y. Chan, Yin-Chen Chen, Ching-Wen Lin, Frank Cheng, Ching-Cher Sanders Yan, Chao-Ping Hsu, Yu-Min Chuang, Jie-Ting Low, Xiaojing Ma, Yao-Ting Huang, Chia-Bin Chang, Chin Li, Hung-Cheng Lai, Shu-Fen Wu, Shih-Hsun Hung, Je-Chiang Tsai. A E2F6 ceRNA network suppresses dendritic cell function, via PBX1/IL-10 signaling, in ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 97.
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Lu, Wenyue, Lin Zhu, Thoin Begum, Yin Tan, Minhhuyen T. Nguyen, Xiaoli Ma, Sarah Lai, et al. "Abstract C100: An effective intervention toolkit to promote medication adherence among Asian Americans living with chronic hepatitis B." Cancer Epidemiology, Biomarkers & Prevention 32, no. 12_Supplement (December 1, 2023): C100. http://dx.doi.org/10.1158/1538-7755.disp23-c100.
Повний текст джерелаАнотація:
Abstract Introduction: Asian Americans is a Hepatitis B (HBV) disparity population who only account for 7% of the US population but experience nearly 60% burden of chronic HBV, which is associated with 75% of hepatocellular carcinoma (HCC). Adherence to HBV medication guideline is a practical approach to preventing liver cancer. However, limited studies have been conducted on promoting HBV medication adherence among underserved Asian American HBV patients. Methods: This study utilized 18-month follow-up data from a randomized controlled clinical trial aimed at improving long-term adherence to HBV medication adherence. Eligible Asian American HBV patients were recruited in the Greater Philadelphia and New York City areas from community-based organizations and clinics that serving the targeted population. Guided by Community-based Participatory Research (CBPR) approach, we developed and implemented Virtual Patient Navigation Toolkit and Text Messaging (VPN Toolkit+TM) to promote HBV pill-taking among the targeted population. HBV medication adherence was assessed using the Morisky 8-Item Medication Adherence Scale with a score ranges from 0 to 8, depression was measured with Patient Health Questionnaire-9, and knowledge of HBV was evaluated with a 10-item scale. A p-value that is smaller than 0.5 is considered statistically significant. Results: Among 149 participants (108 Chinese and 41 Vietnamese) who were prescribed HBV medication, 44.97% were female. Bivariate analysis showed that medication adherence was significantly higher in the intervention group than in the control (7.25 vs. 5.57, p<0.001 ) group at the 18-month follow-up. Results from the multivariable analysis revealed that compared with their control group counterparts, intervention group participants had significantly higher Morisky medication score (Coef.= 0.66, p=0.044), controlling for demographics, depression level, and HBV knowledge score. The results indicated that there was a significant intervention effect in medication adherence at 18-month follow-up. In addition, we found that a lower depression score (Coef.=-0.11, p<0.001) and a higher level of HBV related knowledge (Coef.=0.40, p<0.001) were significant predictors of better HBV medication adherence at 18-month follow-up assessment, with other variables held constant. Conclusion: The findings imply the necessity of promoting VPN Toolkit+ TM intervention among medically underserved HBV pill-taking patients. Moreover, targeted interventions addressing psychosocial barriers and promoting HBV-related knowledge would effectively promote HBV medication adherence among Asian Americans with chronic HBV infection. Citation Format: Wenyue Lu, Lin Zhu, Thoin Begum, Yin Tan, Minhhuyen T. Nguyen, Xiaoli Ma, Sarah Lai, Tam Tran, Phuong Do, Elizabeth Handorf, Ming-Chin Yeh, Grace X. Ma. An effective intervention toolkit to promote medication adherence among Asian Americans living with chronic hepatitis B [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr C100.
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., Nagmani, Dhrubajyoti Das, and Sreeraj Puravankara. "Boosting the Initial Coulombic Efficiency of Sustainable Hard Carbon Derived from Polyethylene Terephthalate with Cyclopentyl Methyl Ether As a Co-Solvent for Wide-Temperature Sodium-Ion Batteries." ECS Meeting Abstracts MA2023-02, no. 1 (December 22, 2023): 123. http://dx.doi.org/10.1149/ma2023-021123mtgabs.
Повний текст джерелаАнотація:
Upcycling plastic waste into value-added products helps to generate cost-effective and sustainable resources towards a circular materials economy and safer ecosystem. The conversion of polyethylene terephthalate (PET) municipal waste via the carbonization process into hard carbon (HC) delivers a high-reversible capacity, low-cost, sustainable anode material for sodium-ion batteries (SIBs). However, the low initial Coulombic efficiency (ICE) is a significant challenge of the HC anode, which should be optimized by electrolyte and interfacial chemistry.1 In conventional carbonate esters-based electrolytes, ethylene carbonate (EC) forms an organic-rich thick SEI layer, soluble on cycling, limiting the cyclic stability. The low-temperature performance is also a significant concern in achieving high capacity, long cyclability, and ICE.2 Herein, HC derived via single-step carbonization at 1000℃ exhibits larger interlayer spacing of 0.379 nm, low surface area (~205 m2g-1), and unique slit-shaped pores with 84% mesoporosity in the structure. PET-HC exhibits a high reversible capacity of 337 mAh g-1 with ICE of just 66%, using EC-PC-based electrolyte. EC-free cyclopentyl methyl ether (CPME) was used due to its weakly solvating and wide temperature solvent.3 CPME-PC-based electrolytes significantly enhanced the ICE value to 74.5% and reversible capacity to 356 mAh g-1 with superior cycling of 91% after 100 cycles at 0.1C rate. The inorganic-rich SEI layer for CPME-PC-based electrolytes results in a thin SEI that improves the ICE and cyclic stability of the anode. The low-temperature performance (up to -20°C) for CPME-PC-based electrolytes showed ~30% added capacity compared to EC-PC-based electrolytes. This work provided an eco-friendly approach to developing hard carbons from plastic trash and offered an effective strategy to replace EC with CPME for low-temperature sodium storage applications. References Shen, L., Shi, S., Roy, S., Yin, X., Liu, W., Zhao, Y., Adv. Funct. Mater. 2021, 31, 2006066. Ramasamy, H. V., Kim, S., Adams, E. J., Rao, H. & Pol, V. G. Chem. Commun. 2022, 58, 5124–5127. Zhang, H., Zeng, Z., Ma, F., Wu, Q., Wang, X., Cheng, S., Xie, J., Angew. Chem. 2023, e202300771. Figure 1
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Zhu, Di, Danny Bracy, Wenyue Lu, Lin Zhu, Elizabeth Handorf, Yin Tan, Ming-chin Yeh, Minhhuyen T. Nguyen, and Grace X. Ma. "Abstract B109: Depression is a risk factor for noncompliance with antiviral medication treatment among Asian Americans with chronic hepatitis B." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (January 1, 2023): B109. http://dx.doi.org/10.1158/1538-7755.disp22-b109.
Повний текст джерелаАнотація:
Abstract Introduction: Asian Americans is a Hepatitis B (HBV) disparity population who only account for 6% of the US population but experience a 60% burden of having HBV, which is associated with 75% of hepatocellular carcinoma (HCC). Adherence to HBV medication is a practical approach to prevent liver cancer. However, limited studies have been conducted on the impacts of depression on HBV medication adherence among underserved Asian American HBV patients. Methods: This study utilized 12-m follow up data from a randomized controlled clinical trial aimed at improving long-term adherence to HBV medication adherence. Eligible Asian American HBV patients were recruited from the Greater Philadelphia Area and New York City. HBV medication adherence was assessed using the 8-Item Morisky Medication Adherence Scale (MMAS-8), and depression was measured with Patient Health Questionnaire-9 (PHQ-9). We conducted OLS regression to examine the association between depression and medication adherence among participants who reported that they were taking antiviral medication for their chronic hepatitis B condition. Results: Among 154 participants (118 Chinese and 36 Vietnamese), 43.57% were female, and 56.49% were male. Nearly all the participants reported having health insurance (92.21%) and having a physician to visit regularly (95.21%). Bivariate analysis showed that depression was negatively significantly associated with medication adherence score (r=-0.55, p<0.001). Multivariable analysis revealed that a higher level of depressive symptoms at baseline significantly predicted poor medication adherence (log odds: -0.16, 95% CI: 4.02-6.89), with other covariates controlled for. In addition, study arm and ethnicity were significant predictors of medical adherence as well. Conclusion: The findings suggest that depression level has significant impacts on medication adherence. This indicates the need for mental health monitoring for CHB patients on antiviral. There are needs for culturally sensitive clinical and community interventions to improve mental health status and medication adherence among this vulnerable population. In addition, we will discuss the successes and challenges in the participant recruitment and intervention implementation process of this study. Citation Format: Di Zhu, Danny Bracy, Wenyue Lu, Lin Zhu, Elizabeth Handorf, Yin Tan, Ming-chin Yeh, Minhhuyen T. Nguyen, Grace X. Ma. Depression is a risk factor for noncompliance with antiviral medication treatment among Asian Americans with chronic hepatitis B [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr B109.
Дисертації з теми "Ma ying long"
1
Dai, Jun Ying, and 戴君穎. "Taiwan's presidential election in 2008:Ma Ying-jeou "Long stay" election propaganda of the agenda-setting." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/42219322985084851590.
Повний текст джерелаАнотація:
碩士玄奘大學
資訊傳播研究所
99
Ma Ying-jeou, presidential candidate of the Kuomintang, wins in 2008 presidential election completely, this election ways tried, run for the simple basic unit that cast aside traditional election war of general headquarters and tie one and visit ticket type journey, change it in order to have purpose, have topic nature ' love the township and do forward '. Finish from July to November, 2007, long to live in, go to the countryside, the deep people in a last few months, not only media's topic has happened in successful construction, mould the image that candidates and basic unit of Taiwan link. This research uses the analytic approach of the text, probe into the view of reporting emphatically while reporting long stay relevant news of every newspaper media, lead the different place, visit propaganda to plan relevant aides and staff in a manner to deepen interview in topic presented to probe into four major newspapers by this, find out about horse's group's band wagon, set up the tactics adopted in topic. And hope to set up media results produced in topic presented with horse's group, carry on comparative analysis, related and differences existed among policy topics put forward after the topic of the newspaper media's report and Ma Ying-jeou Long stay that prove by this. The study found that four newspapers reported long stay in the news, issues-oriented reporting their different focus, and "long stay" propaganda during the election horse team, using the agenda-setting strategies hope to create issues and guide the topics, issues series Sense, the combination of policy and stroke, beyond the "show" the news moves the design, shape close to the real Ma Ying-jeou in Taiwan, also subject to media reports, the main issues to the people like to watch, but the question to try to packaging, media Need the screen, that the important thing is to look at operational issues, it will not all use the horse team to set topics, but higher for news, and people like to watch the main issues.
2
Liou, Jian-cyuan, and 劉建全. "A Study of the Implementation and Effect of Ma Ying Jeou’s Long Stay Campaign Strategy — A Case of Kaohsiung County." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/22mbte.
Повний текст джерелаАнотація:
碩士國立中山大學
高階公共政策碩士班
96
Abstract In Taiwan, although there has been enormous research on voters’ voting behavior and their selections for the candidates, very few studies have been undertaken to analyze the theme of campaign strategy. Especially, given that the presidential election involves a wide variety of election districts and campaign units, currently there is still no related investigation into the implementation of local campaign organizations. For this reason, it is timely and necessary to do the job of evaluating the effect of local campaign strategy. Nominated by KMT for the presidential election, Ma Ying Jeou tries to use the innovative “Long Stay” that is based on the thought of “Blue Ocean Strategy” to reach the various voters, for the purpose of overthrowing the traditional campaign to reset market boundary and thus increase the support for him. However, due to the restriction in large size of districts and long campaign period, it is difficult for Ma’s campaign team to handle all situations which eventually need to depend on the local campaign organizations, in particular the KMT’s local branches, to facilitate. And further, how these local branches plan as well as enact the “Long Stay,” and how to ensure the following operation going smoothly are highly worth studying. More significantly, because the first-ever single-member legislature election was held prior to the presidential election, how the local branches come up with a “Long Stay” schedule that is accepted by the three parties of presidential candidate, legislative candidate, and local community to integrate them into a maximum effort is also worth observing. Accordingly, through participant observation, document analysis and in-depth interview, this study is in an attempt to evaluate how Ma Ying Jeou’s “Long Stay” strategy is implemented and applied. Unlike most research on election that uses statistical data to analyze voters’ voting behavior, this thesis focuses on how the KMT’s Kaohsiung county and its township branches manage to reinforce a series of campaign strategies. Finally, this study would probe into the outcomes of different campaign strategies based on the voting result.
Книги з теми "Ma ying long"
1
Kexiong, Cheng, and Wu Qianqian, eds. Ying tan guai jie - ma long . bai lan duyi wen. Bei jing: Zhong guo dian ying chu ban she, 1990.
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2
Liushan, Zhang, and Zou Sulian, eds. Xian dai deng long shu: Feng ying pai ma cheng gong fa ze. Tai bei shi: He xi chu ban, 1995.
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3
1019-1086, Sima Guang, Rdo-dbis Klu-rgyal-don-grub editor та Mgon-po-skyid editor, ред. Thu-bhod srid skyong lo rgyus me long yig rnying Bod ʼgyur ma: Blo ʼdris sa, Chon Yon-khang. Lan-gru: Kan-suʼu rig gnas dpe skrun khang, 2015.
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4
Han shu you qing: Ma ying long de Minguo wang shi. Wuhan: Hua zhong ke ji da xue chu ban she, 2015.
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5
Ai shen mi ma: Min jian nian hua zhong de qian li yin yuan = The code of the god of love : long distance romantic in new year pictures. Hangzhou Shi: Zhejiang gu ji chu ban she, 2011.
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6
dwangs gsal shel gyi me long / －bod yig gi bka' bstan byung 'phel dang / khyad chos/ par ma khag dpe sdur par skrun byas p'i gns tshul bcas mdor bsdus su bkod p. Pe cin: Krung go'i bod rig pa dpe skrun khang, 2012.
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