Дисертації з теми "Lung conditions"
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Arikatla, Swetha. "Effect of Tumor Microenvironmental Conditions on Non Small Cell Lung Cancer." Scholarly Commons, 2017. https://scholarlycommons.pacific.edu/uop_etds/126.
Повний текст джерелаNilsson, Manja. "Endogenous Nitric Oxide Production and Pulmonary Blood Flow : during different experimental lung conditions." Doctoral thesis, Uppsala universitet, Anestesiologi och intensivvård, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-157162.
Повний текст джерелаTakahashi, Mamoru. "Inhibition of Toll‐like receptor 4 signaling ameliorates lung ischemia‐reperfusion injury in acute hyperglycemic conditions." Kyoto University, 2020. http://hdl.handle.net/2433/253198.
Повний текст джерелаMateu, Jiménez Mercè 1990. "Mechanisms and pathways involved in lung tumor development in patients with chronic respiratory conditions." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/664501.
Повний текст джерелаLas enfermedades crónicas respiratorias, y en especial la enfermedad pulmonar obstructiva crónica (EPOC), así como diversos mecanismos moleculares, podrían ser factores de predisposición al desarrollo de cáncer de pulmón (CP). Hipótesis: La hipótesis de trabajo fue que diferentes mecanismos biológicos como el estrés oxidativo, los procesos inflamatorios y las modificaciones epigenéticas, podrían alterar diversos procesos celulares involucrados en el inicio y en la progresión tumoral en pacientes con EPOC. Objetivos: En tejido pulmonar (tumoral y no tumoral) y en sangre, explorar las diferencias potenciales entre pacientes con CP con y sin EPOC, en diversos mecanismos biológicos que subyacen el desarrollo del tumor pulmonar. Evaluar el perfil diferente de estos mecanismos moleculares entre el pulmón tumoral y no tumoral, tanto en pacientes con CP como en pacientes con CP y EPOC. Métodos: Se determinaron marcadores de estrés oxidativo y nitrosativo, sistemas antioxidantes, citosinas Th1 y Th2, eventos epigenéticos y sus biomarcadores efectores, en el pulmón tumoral y no tumoral de pacientes con CP, con y sin EPOC. También se evaluó el estrés oxidativo y nitrosativo, así como las citosinas Th1 y Th2, en la sangre de pacientes con CP, con y sin EPOC. Resultados: En el tumor pulmonar y en la sangre de los pacientes con CP y EPOC, se observó un aumento del estrés oxidativo y nitrosativo, así como un incremento de la respuesta inflamatoria Th1. La expresión de microRNAs específicos, los niveles de metilación del ADN, y los biomarcadores efectores se vieron alterados en el tumor pulmonar de pacientes con CP y EPOC, lo que a su vez promovió en estos pacientes un aumento de la proliferación celular, la invasión y la angiogénesis. En el tumor pulmonar de los pacientes con CP, con y sin EPOC, se observó un aumento del estrés oxidativo y nitrosativo, un incremento de las citosinas Th1 y Th2, así como alteraciones en los eventos epigenéticos y en los niveles de los biomarcadores efectores. Conclusiones: En los tumores pulmonares y en la sangre de los pacientes con CP y EPOC, existe un perfil de expresión diferente de diversos mecanismos moleculares implicados en el desarrollo tumoral, lo que podría predisponer a los pacientes con EPOC a un mayor riesgo de desarrollar CP.
Wolstenholme, Jane. "Counting the costs of cancer care : breast, cervical and lung cancer in Trent." Thesis, University of Nottingham, 2001. http://eprints.nottingham.ac.uk/12097/.
Повний текст джерелаHoffmann, Franziska Marie [Verfasser]. "Distribution and interactions of pulmonary phagocytes in the murine lung under steady-state conditions and after allergen challenge / Franziska Marie Hoffmann." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2017. http://d-nb.info/1149417862/34.
Повний текст джерелаSoysouvanh, Frédéric. "Sénescence cellulaire radio-induite : application à l’irradiation pulmonaire en conditions stéréotaxiques." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS465.
Повний текст джерелаRadiotherapy is the main modality in cancer treatment but is associated with radiation damages on healthy tissues. Endothelial cells (ECs) play a key role in the evolution of radiation-induced normal tissue injuries. Cellular senescence is a powerful tumor suppressor mechanism but, long-term senescence is deleterious for tissue homeostasis. The presence of senescent cells within the radiation-induced lesions has been shown but their role is not well understood. We aimed to identify and understand the molecular mechanisms involved in radiation-induced senescence (RIS) and its role in radiation-induced lung injuries after stereotactic irradiation. In vivo, using luciferase knock-in mice (p16Ink4-LUC) to detect activation of a senescence player, we explored the presence of senescent cells in radiation-induced pulmonary injury. After high-dose lung irradiation of p16Ink4-LUC mice and using bioluminescence imaging we showed the overexpression of p16 in the irradiation field and its persistence up to 21 months after radiation exposure. Immunostainings revealed a panel of heterogeneous senescent cells including pneumocytes, macrophages and ECs. mRNA expression of 44 genes involved in senescence in 6 human primary irradiated ECs revealed that Human Umbilical Vein Endothelial Cells (HUVECs) are the most relevant in term of gene expression. The dynamic molecular profile associated to RIS in HUVECs was analyzed after 9 doses and 7 time points. Using a deep mathematical/bioinformatics analysis, we deciphered the dynamical transcriptional program involved in RIS and we identified IL1-signaling pathway as a key molecular hub which could modulate the senescence phenotype
Wesche-Franke, Andrea [Verfasser], and Max [Akademischer Betreuer] Schobert. "Characterisation of methionine metabolism of Pseudomonas aeruginosa under conditions resembling a chronic cystic fibrosis lung infection / Andrea Wesche-Franke ; Betreuer: Max Schobert." Braunschweig : Technische Universität Braunschweig, 2014. http://d-nb.info/1175820873/34.
Повний текст джерелаGuerrero, Karen. "Organisation structurale et fonction métabolique des unités énergétiques intracellulaires (ICEUs) dans le muscle cardiaque et squelettique : conditions physiologiques et pathophysiologiques : [Thèse soutenue sur un ensemble de travaux]." Université Joseph Fourier (Grenoble), 2005. http://www.theses.fr/2005GRE10244.
Повний текст джерелаThe aim of this work was to study the regulation of mitochondrial respiration in situ in cardiac and skeletal muscle cells. Oxygraphy, spectrophotometry and confocal microscopy on saponin-permeabilized muscle cells or fibers were used as well as mathematic modelisation. In muscle cells, mitochondria are ordered very precisely in ‘a crystal like pattern'. This intracellular arrangement could be the basis of a structural and functional organisation within which mitochondria are functionally coupled by cytoskeleton to the other organelles: sarcoplasmic reticulum and myofibrils: ICEUs (intracellular energetic units). In cardiac cells, there are two levels of regulation of mitochondrial respiration by exogenous ADP: permeability of the outer mitochondrial membrane (VDAC) and localized restrictions of ADP diffusion in the neighbourhood of mitochondria. β-tubulin and STOP protein, a microtubule-associated protein, participate indirectly to these mechanisms of regulation. These experimental data are useful for explaining the metabolic aspects of the Frank-Starling law of the heart. The notion of ICEU can be diagnostically used in clinical study of energetic metabolism of lung recipients transplants before and after a home-interval training program
Ansari, Naser A. (Naser Awni). "Purification and Characterization of a Differentiation Factor From Rat Lung Conditioned Medium." Thesis, North Texas State University, 1988. https://digital.library.unt.edu/ark:/67531/metadc798062/.
Повний текст джерелаMILLER, LEIGH-ANNE DEBORAH. "SPATIAL-TEMPORAL EXPRESSION OF SONIC HEDGEHOG REGULATES GROWTH, PATTERNING AND BRANCHING MORPHOGENESIS OF THE EMBRYONIC MOUSE LUNG." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1070490268.
Повний текст джерелаAnsari, Naser A. (Naser Awni). "Mechanism of myeloid differentiation induced by a differentiation factor isolated from rat lung conditioned medium." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc798429/.
Повний текст джерелаThissen, François. "Equilibre et mouvement : les conditions historiques de la découverte de la rotation de la lune." Paris 8, 2000. https://octaviana.fr/document/181320525#?c=0&m=0&s=0&cv=0.
Повний текст джерелаDoré, Amphay. "Contribution ethno-historique à la connaissance de la culture Louang-Phrabanaise." Paris 5, 1987. http://www.theses.fr/1987PA05H129.
Повний текст джерелаThe thesis consists in two parts respectively devoted to "geography and economical networks" and to "networks and history". The first part deals with physical and human geography, waterways, thoroughfares and markets. It focusses on the peculiarities of natural environment, especially on provisions in excess which man can immediately make workable, the connections between ethnics facing one another and which have favored lao who conquered valleys, then the economical foundations of state, the whole of economical intercourse and the general outline of trade networks. According to the author's method these matters are not framing determinism which strictly rules historical events as displayed in part 2 but they build a constant reference to think over them. The second part endeavours to frame out the genesis of louang-phrabane se culture from the beginnings to 16th century when it developed its most achieved form. It deals with the question of genesis of lao culture several centuries before our era, especially with the main ethno-linguistic families who originated the lao people. Then, the contribution in administration and socio-political organisation at one time coming from north, at another time from south and which made its way in mid mekhong valley of which louang-phrabang still gives evidences. And then the different religions traditions connected to those northern and southern contributions which were finally superseded by a renewing wave of ceylonese buddhism during the first part of 16th century. This wave has given louang-phrabang a new cultural outline handed down to nowadays
Kanj, Rania S. "Interaction between primary alveolar macrophages and primary alveolar type II cells under basal conditions and after lipopolysaccharide or quartz exposure." Morgantown, W. Va. : [West Virginia University Libraries], 2004. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=34.
Повний текст джерелаTitle from document title page. Document formatted into pages; contains x, 130 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 120-130).
Petit, Maxime. "Residency and trafficking of ILC2 in steady steate and th2 induced inflammatory conditions." Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7095.
Повний текст джерелаILC2s are found in mucosal tissues as lung and intestine, in lymph nodes, and in metabolic tissues such as the adipose tissues. They play important role in maintaining or inducing type-2 immune responses as innate equivalent of Th2 lymphocytes. They are activated by alarmins (IL-25 and IL-33) and by external activators (allergens, metabolites and neuromediators). ILC2s are secreting type-2 cytokines to facilitate the activation of other cells and to induce an important repair program. Their activation allows large type of events as diverse as myeloid cells recruitment and activation, mucus production, muscle contractility and tissue repair. They have key role in lung and adipose tissue development and maintain their homeostasis by early responding against parasitic pathogens. Abnormal activation of ILC2s is also participating to chronic diseases.ILCs are mostly considered as resident cells. However, different studies suggested that migration could be important for the maturation of their effector capacities and to correctly target the injured tissue. Circulation and trafficking of ILC subsets is still unclear. No mechanism is yet available to explain the turnover of ILC2s and how they can act in many tissues following stimuli.We found that large numbers of mature and immature ILC2s could be collected in the thoracic duct lymph of mice perfused over several hours, showing that ILC2s are in fact actively circulating through the hemo-lymphatic circuit. Furthermore, circulating mature ILC2s could be separated into three distinct subsets depending on their pattern of receptor and adhesion molecule expression. Cell transfer experiments proved that specific patterns are representative of specific tropism for gut, lung and adipose tissues.To analyse ILC2 behaviour in the context of a type-2 response, we injected IL-25 and IL-33 before lymph collection. IL-33 stimulation largely enhanced the number of circulating ILC2s in the lymph. These different ILC2 tissue targeted subsets responded differently to IL-33. Specifically, gut-trafficking ILC2s were mainly stimulated to proliferate whereas lung and adipose tissue subsets were stimulated to produce IL-13, IL-5 and Areg. This suggests that, in ILC2s, specific tissue targeting is associated with already imprinted functions while transiting through the hemo-lymphatic system. We confirmed these functions of circulating ILC2 subsets in more physiological context by mimicking allergy and helminth infection (stimulation by papain and succinate) where specific migration to lungs and intestine play important roles in mounting the type-2 response by IL-5/IL-13 secretion, and also initiating tissue repair by Areg production. Interestingly, we showed that lung migrating ILC2s participated to resident pool renewal that main function is Areg production. Finally, we characterized important trafficking of ILC2 at different stages of Nippostrongulus brasiliensis infection, confirming the functional relevance of ILC2 trafficking
Picot, Gautier. "Contrôle optimal géométrique et numérique appliqué au problème de transfert Terre-Lune." Thesis, Dijon, 2010. http://www.theses.fr/2010DIJOS067/document.
Повний текст джерелаThis PhD thesis provides a numerical study of space trajectories in the Earth-Moon system when low-thrust is applied. Our computations are based on fundamental results from geometric control theory. The spacecraft's motion is modelled by the equations of the controlled restricted three-body problem. We focus on minimizing energy cost and transfer time. Optimal trajectories are found among a set of extremal curves, solutions of the Pontryagin's maximum principle, which can be computed solving a shooting equation thanks to a Newton algorithm. In this framework, initial conditions are found using homotopic methods or studying the linearized control system. We check local optimality of the trajectories using the second order optimality conditions related to the concept of conjugate points. In the case of the energy minimization problem, we also describe the principle of approximating Earth-Moon optimal transfers by concatening optimal keplerian trajectories around The Earth and the Moon and an energy-minimal solution of the linearized system in the neighbourhood of the equilibrium point L1
Gallas, Alyssa L. "Lung tumors formed in the TGFΒRII conditional knockout mouse are the result of metastasis from the spontaneous tumor in the anorectal transition zone". University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1406808954.
Повний текст джерелаBoivin-Delpieu, Géraldine. "Conditions d'avancée des savoirs et déterminants de l'action professorale : étude de cas sur l'enseignement des phases de la Lune au cycle 3." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10070/document.
Повний текст джерелаThis PhD analyses the conditions to advance knowledge in class during a science lesson in higher level of primary school (5th grade,10-year-old pupils) of the French elementary school. The teaching situations concern the phases of the moon. From the analysis of effective practices, this research deduce the determiners of teacher’s action and their role.The determiners analysed are : the knowledge, official instructions and teachers’ representations towards science and science teaching. In order to identify these determiners through effective pratices, their characteristics have been established: an a priori analysis of knowledge, official instructions and practical epistemology of teachers is proposed. A questionnaire aiming at collecting data on teachers’ views of science and sciences teaching have been disseminated at the national leevl. An epistemological study of science approach and knowledge guided the elaboration of items and underlies the analysis the official instructions.. The analysis the teachers’ activities is based on the Joint Action Theory in Didactics (JATD). Additional theoretical tools have been integrated to describe the way knowledge progresses in the classroom : epistemic tasks and modeling levels. These additional concepts allow a detailed analysis of the didactic action including the triple genesis, especially chronogenesis. Our research precises the role of epistemic tasks and modeling levels requested in order to advance knowledge and shows that some determinants act primarily to other, depending on the teachers’ tasks concerning the lesson and the anticipation of students’ actions
Rolland, Vincent. "L'intégration des minorités ethniques et des régions montagneuses du nord du Laos : le cas de la province de Luang Namtha, 1995-2015." Master's thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/28127.
Повний текст джерелаSince the beginning of the 1980s, the political and economic changes undertaken by the Laotian State have reshaped the face of the country. These changes work to foster greater integration into international markets and to further develop the country. The results of these transformations are noticeable in rural and mountainous landscape and have influenced the evolution of the ethnic minorities’ livelihoods and lifestyles. The recent development of agro-commercial plantations has contributed to reorganize the socio-economical geography of the northern Laotian provinces, including Luang Namtha. How do local populations adapt to these quick transformations? What changes do these changes involve? This research, which utilizes a multiscalar approach, helps to better understand the inner workings of this integration and the local adaptation process into the national and international systems. KEYWORDS: Laos, integration, rural world, ethnic minorities, livelihoods, adaptation.
Midander, Klara. "Metal Particles – Hazard or Risk? Elaboration and Implementation of a Research Strategy from a Surface and Corrosion Perspective." Doctoral thesis, Stockholm : Kungliga Tekniska högskolan, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-11695.
Повний текст джерела"Pulmonary condition monitoring by percussive impulse response." 1997. http://library.cuhk.edu.hk/record=b6073118.
Повний текст джерелаThesis (Ph.D.)--Chinese University of Hong Kong, 1997.
Includes bibliographical references (p. 204-230).
Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Mode of access: World Wide Web.
SHUN-MING, CHAN, and 詹舜名. "Explore the Potential Relationship between Local Anesthetics and Lung Adenocarcinoma under Hypoxia Condition." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/d275cq.
Повний текст джерела國防醫學院
醫學科學研究所
106
While anesthetics are often used on cancer patients during surgical procedures, their consequence on cancer progression remains to be clarified. In this study, we sought to investigate the mechanism of the influence of local anesthetics on lung cancer cell dissemination in vitro and in vivo. A549 and H1975 human lung adenocarcinoma cancer cells were processed with various local anesthetics including ropivacaine, lidocaine, levobupivacaine and bupivacaine. The cell barrier property was evaluated using an electric cell-substrate impedance sensing (ECIS) system. The epithelial-to-mesenchymal transition (EMT) of treated cells was analyzed by immunofluorescence staining. In vitro and in vivo cancer cell dissemination were investigated. Gene expression microarray and quantitative real-time PCR (qrt-PCR) assays were used to identify the genes responsible for levobupivacaine-mediated cancer cell dissemination. The results illustrated that only levobupivacaine induced EMT in the treated A549 cells and also caused the dissemination of cancer cells in vitro. In addition, after intravenous injection, levobupivacaine encouraged cancer cell dissemination in vivo (7/10 in the levobupivacaine treatment group compared to 1/10 in the control group). Gene expression microarray, qrt-PCR and immunoblotting revealed that after levobupivacaine treatment, the hypoxia-inducible factor (HIF)- 2α gene was upregulated in cancer cells. Our findings suggest that levobupivacaine may induce A549 lung cancer cell dissemination both in vitro and in vivo. More specifically, HIF-2α signaling possibly contributes to levobupivacaine-mediated A549 lung cancer cell spreading.
Lin, Shih-Shiuan, and 林士鉉. "Neural crest stem cell conditioned medium improves ischemia/reprefusioninduced acute lung injury." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/56001810307598166001.
Повний текст джерела國防醫學院
航太及海底醫學研究所
102
Backgrounds: Reperfusion injury after pulmonary transplantation can contribute significantly to postoperative pulmonary dysfunction. Despite extensive research into the pathogenesis and management of ischemia-reperfusion (IR)-induced lung injury, inhospital mortality still remains high. In several preclinical studies, adult stem cells have been proved to be therapeutic ability through paracrine mechanisms. We hypothesized that neural crest stem cell (NCSC)-derived conditioned medium (CdM) protects against IR-induced lung injury. Materials and Methods: In 24 adult male Sprague-Dawley rats (300-350g), acute lung injury was induced in clinically relevant ex vivo animal model. Animal were divided into four group (n=6 in each group):the control group, the ischemia-reperfusion(IR) group, the IR+Medium only group, the NCSC-CdM group (IR+CdM), and the heated CdM group (IR+heated CdM). Results: IR activated IKK-NFκB inflammation pathway and caused acute lung injury as evidenced by the increases in BALF concentration, pulmonary arterial pressure, lung weight to body weight ratio, wet to dry ratio of lung weight, and filtration coefficient. Adding CdM to the perfusate significantly suppressed inflammation and attenuated lung injury caused by IR. The protective effects, however, diminished when the CdM was priorly heated. Conclusion: NCSCs may secret heat vulnerable factors that suppresses inflammatory response and attenuate acute lung injury caused by ischemia and reperfusion in isolated rat lungs.
Chen, Wan-Ping, and 陳婉平. "A diagnosis model for survivability and medical expenditure of lung cancer patient by Conditional Gaussian Bayesian networks." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/sqn4ey.
Повний текст джерела國立臺灣科技大學
工業管理系
106
In Taiwan, the statistics of the Ministry of Health and Welfare indicated lung cancer is the leading cause of cancer. About 10,000 new cases of lung cancer each year, which caused more than 7,000 people dead in 2016. In addition, lung cancer usually accompanied with comorbidity which was negatively associated with survival and leaded to medical financial burden. This study used National Health Insurance Research Database from 1996 to 2010 who diagnosed lung cancer, and 85,745 cases were selected as experiment data. By using Kaplan-Meier estimation to get residual life of patient and used risk factors to construct Conditional Gaussian Bayesian network model of survivability and medical expenditure. The prediction R-square of survivability in stage I is 69.50%, stage II is 73.75%. The prediction R-square of medical expenditure in stage I is 93.95%, stage II is 74.77%. And proposed model not only can predict survivability and medical expenditure, but also can calculate the posterior probability of variety of medical related query.
Liao, Yuwen, and 廖郁紋. "The Study of Anti-Angiogenesis Effects of Dextromethorphan (DXM) in Non-Small Cell Lung Cancer (NSCLC) under Hypoxic Condition." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/19661472193275130763.
Повний текст джерела國防醫學院
生理學研究所
99
In Taiwan, lung cancer is the first place in top ten causes of cancer death, and there is increasing trends recent years. The survival rate of lung cancer is only about 10% of in 5 years. Its biological characteristic and clinical manifestation of lung cancer are divided into small cell lung cancer (SCLC) and non-small cell lung cancer(NSCLC). Tumour hypoxia is a microenvironmental feature of chronically inflamed tissues. ROS levels are increased in hypoxia. Two central transcription factors involved in the regulation of this response are hypoxia inducible factor (HIF) and nuclear factor-κb (p65 NF-κB) which demonstrate an intimate interdependence at several mechanistic levels. Previous studies have shown that activation of hypoxia-inducible factor 1alpha (HIF-1α) during hypoxia, triggering various target genes expression including vascular endothelial growth factor (VEGF), plays an important role in tumor angiogenesis and progression. Dextromethorphan (DXM) is the most commonly used as an antitussive drug. DXM is also used to suppress cough on late stage lung cancer patients. Recently, several studies have shown that DXM exerts an antioxidative activity, attenuates vascular oxidative stress formation and inflammatory markers functions. However, in hypoxia condition, effects of Dextromethorphan on HIF-1α-mediated angiogenesis in human lung adenocarcinoma epithelial cell are still unreported.
Liu, Chia-Hao, and 劉家豪. "Suppression of cigarette smoke extract induced cell death and epithelial-mesenchymal transition in lung epithelial cells by adipose-derived stromal cell condition medium." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/27297806884756074539.
Повний текст джерела國立清華大學
生醫工程與環境科學系
103
Chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer are deadly disease related to smoking. COPD and lung cancer were among the 10 leading causes of death in the world in 2012. Previous studies suggest that epithelial-mesenchymal transition (EMT) may play a role in COPD, IPF and lung cancer; however, the mechanism linking EMT to these dieases remains incompletely understood. EMT describes a biological process by which epithelial cells lose their epithelial characteristics and gradually acquire mesenchymal traits, and this process mainly occurs in embryogenesis, tissue regeneration, organ fibrosis, cancer progression and metastasis. The causes of lung diseases mentioned above are highly associated with fibrosis, cancer progression and metastasis. Therefore, study on cigarette smoke-induced EMT in lung epithelial cells contributes to understanding and better treatment for these diseases. We investigated the effect of cigarette smoke extract (CSE) on human lung epithelial A549 cell line in vitro. Our results demonstrated that CSE induced A549 cell death in a concentration- and time-dependent manner. In addition, the cells escaped from CSE-induced cell death exhibited some EMT properties: elongated shape, lack of apical microvilli, increased motility, decreased E-cadherin expression, and increased Vimentin and -smooth muscle actin expression. Recent studies suggest the therapeutic potential of mesenchymal stem cells for lung diseases, which is probably mediated by paracrine actions of mesenchymal stem cells. Accordingly, A549 cells were cultured with adipose-derived stem cell condition medium (ADSC-CM), and we found that ADSC-CM had a protective effect on CSE-induced cell death; moreover, ADSC-CM repressed CSE-indued EMT properties in A549 cells. These results imply that microenvironment plays an important role in EMT induction. A549 cells tended to undergo EMT in adverse condition, but CSE induced EMT properties in A549 cells became less evident in a less adverse condition such as with the inclusion of ADSC-CM. Finally, we investigated EMT related genes by microarray analysis. After CSE exposure, we found that genes as epithelial markers were downregulated in A549 cells, but only few genes as mesenchymal markers were upregualted. As a result, A549 cells underwent “partial EMT” by CSE induction, and we show that such EMT-like phenomena can be further confirmed by microarray analysis. In summary, we demonstrated the effect of CSE on A549 cells, including cell death and EMT. Furthermore, we discussed EMT-like features in A549 cells via different methods for image analysis. Finally, we used ADSC-CM to repress CSE-indued cell death and EMT in A549 cells, which suggest that ADSCs have therapeutic potential for smoking related lung diseases by paracrine actions.