Дисертації з теми "Live box"
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Mutashar, Rana O. "Response of Skewed Composite Adjacent Box Beam Bridge to Live and Environmental Load Conditions." Ohio University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1597020452615694.
Повний текст джерелаSharifi, Hossein. "EVALUATION OF 2-CELL RC BOX CULVERTS." UKnowledge, 2018. https://uknowledge.uky.edu/ce_etds/66.
Повний текст джерелаSenthilvasan, Jeevanandam. "Dynamic response of curved box girder bridges." Thesis, Queensland University of Technology, 1997.
Знайти повний текст джерелаHodson, Dereck J. "Live Load Test and Finite Element Analysis of a Box Girder Bridge for the Long Term Bridge Performance Program." DigitalCommons@USU, 2011. https://digitalcommons.usu.edu/etd/835.
Повний текст джерелаField, Carrie Stoshak. "VHPC Material Characterization and Recommendations for the Buffalo Branch Bridge Rehabilitation." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/75066.
Повний текст джерелаMaster of Science
Pockels, Leonardo A. "Live-Load Test and Computer Modeling of a Pre-Cast Concrete Deck, Steel Girder Bridge, and a Cast-in-Place Concrete Box Girder Bridge." DigitalCommons@USU, 2009. https://digitalcommons.usu.edu/etd/508.
Повний текст джерелаBuelens, Saarke. "Inside the 'black box' : a critical interpretive perspective on the internal dynamics of schooling at Learn to Live and their impact on youths' at risk social-educational status." Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/7775.
Повний текст джерелаParticipation in social and educational environments is crucial for young people’s development, well-being and opportunities for leading a fulfilling and successful life. Many South African youngsters – and particularly street children – are often excluded from meaningful participation in their communities. This involves participation in social, educational, cultural, political and economic life. The family and the school are two important arenas where such participation can take place. In addition, these youngsters are confronted with unpredictable future life chances. Thus, they often find themselves in a disadvantaged position within society. In light of this observation, the theme of youth at risk has been much discussed in South Africa for the past three decades. This study focuses on a group of especially disadvantaged adolescents, who do not live in safe and nurturing family environments and who are excluded from formal education. I investigate whether ‘theories and practices of education’, featured in non-formal educational interventions, have an impact on the reproduction of disadvantage and risk among its students. My research focuses on the case of Learn to Live, a non-formal educational intervention that tries to counteract the disadvantages that especially disadvantaged youth in Cape Town face.My findings show that educators and students try to find a balance between, on the one hand, emphasising the uniqueness of students’ extremely disadvantaged situation and the need for a particular kind of education that results from it, and on the other hand, the desire to conform to mainstream ideas and mainstream adolescent life. In their attempts to find this balance, nearly all participants acknowledge that Learn to Live is a necessary stepping stone in students’ lives towards success and happiness. The educators believe that the school itself can contribute a lot to the students’ situation and emphasise their role of victims of their circumstances. The students, however, state that Learn to Live is merely there to give them a second chance. They do consider their own role in the schooling process and the path to success to be paramount. This is also reflected quite clearly in the students’ aspirations, their feelings of hope, and their looking to the future. The implications of these findings for Learn to Live include: building on students’ strengths, talents and resiliency by offering them an empowerment-based intervention, creating more opportunities where students can experience feelings of success and pride, and making use of testimonies of successful students.
Dítě, Miroslav. "Network Voice Message Box." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-218133.
Повний текст джерелаHallberg, Daniel. "Life Inside the Box : Tolka min ström av tankar." Thesis, University of Skövde, School of Humanities and Informatics, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-3227.
Повний текст джерелаFlores, Corrales Marco Antonio, Gomero José Alonso Pozo, Muñante Sofia Alejandra Rodriguez, Zúñiga Arianna Belen Rojas, and Aparicio Jimena Villaseca. "Proyecto Healthy Box." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2021. http://hdl.handle.net/10757/656840.
Повний текст джерелаDue to the current situation caused by COVID-19, there is a trend among consumers to opt for a healthier lifestyle, generating changes in many aspects of their daily routine. Some of the most important changes were to exercise at home after the restrictions imposed by the government and to eat in a healthy way, leaving aside those products that are harmful to health. In consideration of the increase of this trend is that the research was conducted to provide a service to improve, promote and maintain a healthy lifestyle. Therefore, "Healthy Box" was born as a bio-healthy and effective business idea that seeks to be the intermediary for companies in the healthy sector, offering a delivery service with a variety of products to men and women from 18 to 45 years of age from the AB socioeconomic level who want to maintain or wish to start a healthier lifestyle. On the other hand, in order to test the feasibility and the intention to acquire our service, different experiments were carried out. The analysis showed that, with a total investment of S/. 79,427, in the first year of operations, the net profit will be -S/.29,651.66, for the second year S/.153,989.26 and for the third year S/.166,694.79. Finally, the project investment can be recovered in the established time and produced an NPV of S/.122,504.55, which demonstrates the profitability of the business.
Trabajo de investigación
Katsoulas, Dimitrios. "Robust recovery of piled box-like objects in range images." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976790939.
Повний текст джерелаMYGDALSKYY, VOLODYMYR. "Analysis of stress field of box-like shells with cracks." 京都大学 (Kyoto University), 2002. http://hdl.handle.net/2433/149381.
Повний текст джерелаVan, Der Linden Lize-Mari. "Functional Characterization of Plasmodium falciparum TATA-box binding-like Protein (PfTLP)." Master's thesis, Faculty of Science, 2019. http://hdl.handle.net/11427/31322.
Повний текст джерелаHolmberg, Marc. "Life Time BoM : BoM-effektivisering ur ett Lean-perspektiv." Thesis, Umeå universitet, Institutionen för tillämpad fysik och elektronik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-165185.
Повний текст джерелаYalcinkaya, Sukru. "Black Box Groups And Related Group Theoretic Constructions." Phd thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/12608546/index.pdf.
Повний текст джерелаs ``Classical Involution Theorem'
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as a model in the final recognition algorithm and we propose an algorithm which constructs all root SL_2(q)-subgroups corresponding to the nodes in the extended Dynkin diagram, that is, our approach is the construction of the the extended Curtis - Phan - Tits presentation of the finite simple groups of Lie type of odd characteristic which further yields the construction of all subsystem subgroups which can be read from the extended Dynkin diagram. In this thesis, we present this algorithm for the groups PSL_n(q) and PSU_n(q). We also present an algorithm which determines whether the p-core (or ``unipotent radical'
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) O_p(G) of a black box group G is trivial or not where G/O_p(G) is a finite simple classical group of Lie type of odd characteristic p answering a well-known question of Babai and Shalev. The algorithms presented in this thesis have been implemented extensively in the computer algebra system GAP.
Södergren, Jacob. "The Impact of a Teracom Group Product From a Life Cycle Perspective." Thesis, KTH, Industriell ekologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-118479.
Повний текст джерелаAu, Chun-hei Victor, and 區晉熙. "The role of ankyrin repeats and SOCS box protein 4 (ASB4) in hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196475.
Повний текст джерелаpublished_or_final_version
Surgery
Master
Master of Philosophy
Wood, Steven L. "Cavitation effects on a ship-like box structure subjected to an underwater explosion." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1998. http://handle.dtic.mil/100.2/ADA354937.
Повний текст джерела"September 1998." Thesis advisor(s): Young S. Shin. Includes bibliographical references (p. 115-116). Also Available online.
Stokes, Jamie Edward. "Small molecule approaches targeting the Polo-box domain of Polo-like kinase 1." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648778.
Повний текст джерелаFlood, Hannah M. "The Forkhead Box F1 Transcription Factor in Disease and Development." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554213082789579.
Повний текст джерелаTsang, Ho-ching Felice. "Identification of ankyrin repeats and SOCS box protein 4 (ASB4) as oncogenic biomarker in liver cancer." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40738814.
Повний текст джерелаReindl, Wolfgang. "Inhibition of polo-like kinase 1 by small molecules targeting the polo-box domain." kostenfrei, 2008. http://mediatum2.ub.tum.de/doc/650458/650458.pdf.
Повний текст джерела曾可澄 and Ho-ching Felice Tsang. "Identification of ankyrin repeats and SOCS box protein 4 (ASB4) as oncogenic biomarker in liver cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40738814.
Повний текст джерелаDu, Preez Hannelie. "In die teenwoordigheid van outisme : 'n moeder se verkenning van emosionele intelligensie in haar lewensverhaal." Diss., University of Pretoria, 2010. http://hdl.handle.net/2263/31210.
Повний текст джерелаENGLISH : The rationale for this study was to gain a better understanding of what it means to be the mother of a child with autism, through the use of narrative research accounts. The mother (participant), and I (researcher) furthermore utilized the sources of collected data, such as her life story, to identify components of emotional intelligence with the purpose of additional interpretation. A narrative research design, firmly rooted in an interpretivist and constructivist paradigm, should therefore serve to accurately interpret the significant emotions and other lived-experiences that a mother attaches to living with a child that has been diagnosed with autism. A multi-method approach, directed by a qualitative research approach and a narrative research design, was followed in an attempt to capture the mother‘s experiences and life story. Data collection strategies employed to generate an in-depth, rich and personal life story consisted of the following activities: an informal interview, memory box (collages, anecdotes, life line, and methaphors) and an intellectual discussion regarding emotional intelligence. The mother also participated in a collaborative discussion to identify emotional intelligence components relevant to her life story. Further collaboration and discussion with the mother were required to ensure that the data were organised, analysed and interpreted according to the mother‘s lived-experiences of autism, along with her emotions that were identified on the basis of Bar-On‘s (2003) emotional intelligence components. The meaningful findings drawn from the mother‘s narratives (in relation to the identified emotional intelligence components) suggest that the mother demonstrates an optmistic, realistic and introspective view on parenting. It can be regarded as accountable for me as researcher to state that the mother displays an educated an comprehensive understanding of the disability with which her child is living. The mother perhaps best summarises her experiences of autism in the words of Emily Pearl Kingsley‘s inspirational words: “Say goodbye to the child you wanted, or else your focus will never be with the child you have.”
Dissertation (MEd)--University of Pretoria, 2010.
Educational Psychology
Unrestricted
Frederick, Nicolas. "Examining the Effects of Penning on Juvenile Eastern Box Turtles (Terrapene carolina carolina)." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/27.
Повний текст джерелаYe, Dewei, and 叶得伟. "Toll-like receptor-4 mediates obesity-induced nonalcoholic steatohepatitis through activation of X-box binding protein-1 in mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47752919.
Повний текст джерелаpublished_or_final_version
Medicine
Doctoral
Doctor of Philosophy
Zhang, Tianzi. "The possibility of using BOD on-line measurement." Thesis, KTH, VA-teknik, Vatten, Avlopp och Avfall, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-99358.
Повний текст джерелаBeiter, Keith A. "The effect of stiffener smearing in a ship-like box structure subjected to an underwater explosion." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1998. http://handle.dtic.mil/100.2/ADA353271.
Повний текст джерелаZhang, Meng. "UAP56: A Dead Box Protein Required for Pre-mRNA Splicing: A Dissertation." eScholarship@UMMS, 1999. http://escholarship.umassmed.edu/gsbs_diss/173.
Повний текст джерелаSelmi, Abdelkader. "Les gènes TWIST : cibles transcriptionnelles des gènes MYC dans le neuroblastome." Phd thesis, Université Claude Bernard - Lyon I, 2009. http://tel.archives-ouvertes.fr/tel-00535535.
Повний текст джерелаVillafana, Johans. "The Life and the death of commercail email : En studie av e-postens geografi med hjälp av Actor Network Theory." Thesis, Stockholms universitet, Kulturgeografiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-58705.
Повний текст джерелаCassinelli, Joe P., R. Ignace, W. Waldron, J. Cho, N. Murphy, and A. Lazarian. "X-ray line emission produced in clump bow shocks." Universität Potsdam, 2007. http://opus.kobv.de/ubp/volltexte/2008/1805/.
Повний текст джерелаAlbuquerque, Camila Rodrigues Cavalcanti de. "Áreas de livre comércio : o caso de Boa Vista." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/35438.
Повний текст джерелаThe free trade areas are tax benefits institutes whose main objective is to promote the poor regions‟ development. The free trade area of Boa Vista, along with the Bonfim‟s, was the last to be deployed, in 2008, and its impacts are assessed through a questionnaire applied to companies of Boa Vista, in order to understand the satisfaction degree of businesses, barriers and perspectives of ALC of Boa Vista. For these reasons, we interviewed 53 companies, which represent 3.22% of the universe of companies registered and entitled Boa Vista in SUFRAMA, a situation necessary for companies to have access to the benefits of the ALC. The sample analysis shows that 69.81% of respondents say that their companies do have ALC‟s benefits. From this number, the assessment about the most significant incentives for the company, in descending order was: PIS/COFINS, ICMS, IPI and Import Tax. Among the main obstacles, respondents highlighted: few incentives for municipal and government; high shipping cost, shortage of skilled labor, lack of bonded port, difficulty in clearing the border with the state of Amazonas, among others. About the degree of satisfaction, the majority indicated satisfaction Average (39.62%). Nevertheless, most respondents (28.30%) said they had not obtained any reduction in prices of products purchased. The next most selected response was that the prices of purchased products reduced from 10.01 to 15% (26.42% of responses). The survey also indicated that a significant number of entrepreneurs do not know the benefits of targeted ALC imports (45.28%) and unknown benefits to industry (83.02%). Taking into account the perspective of growth and development, these concepts, as well as aspects of impacts of tax relief, regional disparities in development and the gains from international trade, among others, are addressed in this study.
Krabbendam, Johannes Leendert. "The model man : a life of Edward W. Bok, 1863-1930 /." [Leiden] : J. L. Krabbendam, 1995. http://catalogue.bnf.fr/ark:/12148/cb36182191x.
Повний текст джерелаPuig, Jérôme. "Etude de gènes de type MADS-box chez le riz, homologues des gènes du clade AGL17-like d’Arabidopsis thaliana." Thesis, Montpellier 2, 2011. http://www.theses.fr/2011MON20144.
Повний текст джерелаThe aim of this work was to study AGL17-like clade MADS box transcription factors (OsMADS23, OsMADS25, OsMADS27 and OsMADS61) in rice development. First, we analyzed expression patterns of the different genes. We showed that OsMADS23, OsMADS25 and OsMADS27 are mainly expressed in the central cylinder of roots; OsMADS57 in aerial parts and OsMADS61 in stem base. Then, we showed that all these have a different response to osmotic and salt stresses, nitrate and hormone. This suggests that these genes have distinct and no redundant functions. My work focused on functional characterization of OsMADS25 which is specifically expressed in root stele. T-DNA mutant Osmads25 presents aerial phenotype characterized by drastic reduction of culm number; and also a root phenotype characterized by a strong decrease of adventitious root number. This phenotype was mimicked by the creation of transgenic lines overexpressing cDNA OsMADS25 in fusion with the “EAR” motif, which acts as a dominant repressor of transcription. These results added to mutant complementation by overexpression of corresponding cDNA show that OsMADS25 acts as an positive regulator of axillary meristem and nodal root development in rice; acting probably from root to stem base via a systemic pathway. Complementary studies as regards mutant microscopic phenotyping are in progress to precise the role acting by OsMADS25 on initiation or development of axillary buds. RT-qPCR analyses showed that this gene is involved in rice development by an strigolactones-independent pathway. On the other hand, expression if transcription factors as OsNAC2 and OsMOC1, known to be involved in tiller development, or as CRL1, regulator of adventitious root primordia initiation, are decreased in Osmads25; suggesting that OsMADS25 could directly or indirectly regulate expression of these genes. Eventually transcriptomic analyses between Osmads25 and WT revealed inhibition of expression of 60 genes which 9 have relative function to secretion mechanism, auxin transport or development. Interestingly, one of its, RCN4/Oscen4 belonging to mobile protein family known to regulate meristem activity and which could constitute a systemic molecular intermediary between root and stem base allowing to explain the controlled phenotype by OsMADS25
Laurent, François-Xavier. "Une nouvelle fonction pour la DEAD-box ARN hélicase p68/DDX5 dans la Dystrophie Myotonique de type 1." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00662593.
Повний текст джерелаMoon, Amberly. "Head-start Juvenile and Adult Resident Eastern Box Turtles (Terrapene carolina carolina): Winter Ecology Including Microhabitat Selection, Temperature Tolerance and Philopatry." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/644.
Повний текст джерелаWamucho, Anye. "Cloning, Heterologous Expression in Yeast, and Biochemical Characterization of Recombinant Putative Glucosyltransferase Clones 9 and 11 from Grapefruit (Citrus paradisi)." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etd/1214.
Повний текст джерелаRicks, Joi Elizabeth. "Living outside the box: sustaining the lifelong community through universal design." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34732.
Повний текст джерелаReis, Márcio Alexandre de Oliveira. "Loops de Bol algébricos e analíticos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/45/45131/tde-27062010-143306/.
Повний текст джерелаIn this work, we classify up to isomorphism, the Bol algebras of dimension 2 over a eld of characteristic 0. We also determine their enveloping Lie algebras and we exhibit two non-isomorphic Bol algebras which have isomorphic enveloping Lie algebras. We determine the (local) correspondent algebraic groups of each of those enveloping Lie algebras and we show that every global analytic (algebraic) Bol loop of dimension 2 over a eld of characteristic 0 is a group. We exhibit examples of non-nilpotent solvable algebraic Bol loops in dimension n for every n > 2, and we were able to give a necessary and sucient condition to decide if a local algebraic Bol loop is global when its enveloping Lie algebra is nilpotent of index 2 and char(F) 6= 2:
Batista, Emiliana de Oliveira Santana. "Resposta ovariana, endócrina e molecular de novilhas taurinas e zebuínas submetidas a diferentes níveis nutricionais de ingestão de matéria seca." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10131/tde-15122015-093720/.
Повний текст джерелаThe objective of this study was to evaluate the circulating progesterone (P4) concentration, ovarian follicular dynamics, and liver-gene expression of genes (CYP2C19, CYP3A4, SRD5A1, SRD5A3, AKR1C4, AKR1D1) associated to P4 metabolism in Nelore (n = 16) and Holstein (n = 16) heifers, kept in high (HDM) or low (LDM) dry matter intake according NRC (2001) during a timed AI protocol. The experiment was performed in a cross-over factorial 2 x 2 design. The experimental diet was fed for a period of 34 days. Heifers were presynchronized with two prostaglandin treatments (500 µg,i.m. PGF2α, Sincrocio®, Ourofino Agronegócio) given 12 days apart (D-14 e D-12). Two further PGF2α treatments were also performed 18 and 12 h before device insertion (D0). At the beginning of the synchronization protocol (D0), all heifers received an intravaginal P4 device (CIDR®, Zoetis, Brazil), 2 mg i.m. of estradiol benzoate (BE, Sincrodiol®, Ourofino Agronegócio) and a PGF2α treatment. Eight days later, the P4 device was removed and 1 mg of BE was applied i.m. 24h later. Ultrasound exams took place at every 24h throughout the P4 device insertion period, at 12h intervals from device removal to ovulation, and again on D14 and D17 to measure corpus luteum (CL) volume. Daily blood sampling was performed from D0 to D10. A single liver biopsy was done 48 h after P4 device insertion (D2). The PROC MIXED procedure was used to analyze data from follicular dynamics and hormonal profiles, and gene expression records were analyzed by the PROC GLIMMIX of SAS 9.3. Results are presented as mean ± SEM. The number of recruited follicles was greater in Nelore than in Holstein heifers (42.1 ± 3.4 vs. 23.5 ± 3.3, P < 0.001). The diameter of the dominant follicle (mm) was greater in Holstein than in Nelore heifers (14.5 ± 0.4 vs. 13.0 ± 0.4, P = 0.009) and also for HDM heifers than for LDM (14.8 ± 0.4 vs. 12.7 ± 0.4; P = 0.0004). In addition, Holstein heifers had greater CL volume (mm3) than Nelore (6195 ± 427 vs. 3507 ± 461; P < 0.0001). Heifers submitted to BCMS have greater concentrations of P4 during the protocol that heifers submitted to ACMS (P < 0.05), and this is most evident in Nelore heifers (breed * diet, P < 0,05). Holstein heifers had greater mRNA expression of SRD5A1, AKR1C4 and AKR1D1 (P < 0.05) than Nelore heifers. The mRNA expression of the gene CYP3A4 was greater though in Nelore compared Holsteins (P < 0.0001). Furthermore, the mRNA expression of AKR1D1 was greater in heifers on HDM than in LDM (P = 0.004). In contrast, the mRNA expression of AKR1C4 was more expressed in heifers on LDM compared to HDM (P = 0.01). In conclusion, these results suggest that both cattle breed as well as level of dry matter intake can alter P4 metabolism, follicular dynamics and gene expression in heifers supplemented with exogenous P4 during synchronization programs.
Svensson, Viktor. "Navigating an AI-bot within Game-like Environments using Genetic Algorithms." Thesis, Blekinge Tekniska Högskola, Sektionen för datavetenskap och kommunikation, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-2723.
Повний текст джерелаArbetet handlar om hur man kan använda Genetiska Algoritmer för att lära en AI att röra sig igenom ett område med hinder för att hitta ett mål.
Ghasemi, Sara. "Comparative Life-Cycle Assessment of Slurry vs. Wet Carbonationof BOF Slag." Thesis, KTH, Skolan för kemivetenskap (CHE), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-180552.
Повний текст джерелаLind, Roger. ""En bok om att få ett bättre liv" : Självhjälpslitteraturens strategier till ett lyckosamt liv." Thesis, University of Kalmar, School of Human Sciences, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-1980.
Повний текст джерелаFeldman, Polina. "The role of high mobility group box 1 and toll like receptor 4 in a rodent model of neuropathic pain." Thesis, Indiana University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3617301.
Повний текст джерелаNeuropathic pain is a serious health problem that greatly impairs quality of life. The International Association for the Study of Pain (IASP) defines neuropathic pain as `pain arising as a direct consequence of a lesion or disease affecting the nervous system'. It is important to note that with neuropathy the chronic pain is not a symptom of injury, but rather the pain is itself a disease process. Novel interactions between the nervous system and elements of the immune system may be key facets to a chronic disease state. One of particular note is the recent finding supporting an interaction between an immune response protein high mobility group box 1 (HMGB1) and Toll like receptor 4 (TLR4). HMGB1 is an endogenous ligand for TLR4 that influences the induction of cytokines in many non-neuronal cells. After tissue damage or injury, HMGB1 may function as a neuromodulatory cytokine and influence the production of pro-nociceptive mediators altering the state of sensory neurons. Very little is known about the HMGB1-TLR4 interaction in sensory neurons and whether chronic changes in endogenous HMGB1 signaling influence the establishment of neuropathic pain. This thesis aims to determine whether a physiologically relevant neuroimmune interaction involving endogenous HMGB1 and TLR4 in the dorsal root ganglia is altered following a tibial nerve injury model of neuropathic pain. I hypothesized that sensitization of sensory neurons following a peripheral nerve injury is dependent on endogenous HMGB1 and TLR4. The studies presented here demonstrate that HMGB1 undergoes subcellular redistribution from the nucleus to the cytoplasm in primary afferent neurons following peripheral nerve injury. Further, the presence of extracellular HMGB1 may directly contribute to peripheral sensitization and injury-induced tactile hyperalgesia. Though thought to be important as a pivotal receptor for HMGB1 activation, neuronal protein expression of TLR4 does not appear to influence the effects of HMGB1-dependent behavioral changes following peripheral nerve injury. Taken together, these findings suggest that extracellular HMGB1 may serve as an important endogenous cytokine that contributes to ongoing pain hypersensitivity in a rodent model of neuropathic pain.
Penadés, Plà Vicent. "Life-cycle sustainability design of post-tensioned box-girder bridge obtained by metamodel-assisted optimization and decision-making under uncertainty." Doctoral thesis, Universitat Politècnica de València, 2021. http://hdl.handle.net/10251/147480.
Повний текст джерела[ES] Actualmente existe una tendencia hacia la sostenibilidad, especialmente en los países desarrollados donde la preocupación de la sociedad por el deterioro ambiental y los problemas sociales ha aumentado. Siguiendo esta tendencia, el sector de la construcción es uno de los sectores que mayor influencia tiene debido a su alto impacto económico, ambiental y social. Al mismo tiempo, existe un incremento en la demanda de transporte que provoca la necesidad de desarrollo y mantenimiento de las infraestructuras necesarias para tal fin. Con todo esto, los puentes se convierten en una estructura clave, y por tanto, la valoración de la sostenibilidad a lo largo de toda su vida es esencial. El objetivo principal de esta tesis es proponer una metodología que permita valorar la sostenibilidad de un puente bajo condiciones iniciales inciertas (subjetividad del decisor o variabilidad de parámetros iniciales) y optimizar el diseño para obtener puentes óptimos robustos. Para ello, se ha realizado una extensa revisión bibliográfica de todos los trabajos en los que se realiza un análisis de la sostenibilidad mediante la valoración de criterios relacionados con sus pilares principales (económico, medio ambiental o social). En esta revisión, se ha observado que la forma más completa de valorar los pilares medioambientales y sociales es mediante el uso de métodos de análisis de ciclo de vida. Estos métodos permiten llevar a cabo la valoración de la sostenibilidad durante todas las etapas de la vida de los puentes. Todo este procedimiento proporciona información muy valiosa a los decisores para la valoración y selección del puente más sostenible. No obstante, las valoraciones subjetivas de los decisores sobre la importancia de los criterios influyen en la evaluación final de la sostenibilidad. Por esta razón, es necesario crear una metodología que reduzca la incertidumbre asociada y busque soluciones robustas frente a las opiniones de los agentes implicados en la toma de decisiones. Además, el diseño y toma de decisiones en puentes está condicionado por los parámetros inicialmente definidos. Esto conduce a soluciones que pueden ser sensibles frente a pequeños cambios en dichas condiciones iniciales. El diseño óptimo robusto permite obtener diseños óptimos y estructuralmente estables frente a variaciones de las condiciones iniciales, y también diseños sostenibles y poco influenciables por las preferencias de los decisores que forman parte del proceso de toma de decisión. Así pues, el diseño óptimo robusto se convierte en un proceso de optimización probabilística que requiere un gran coste computacional. Por este motivo, el uso de metamodelos se ha integrado en la metodología propuesta. En concreto, se ha utilizado hipercubo latino para la definición de la muestra inicial y los modelos kriging para la definción de la aproximación matemática. De esta forma, la optimización heurística basada en kriging ha permitido reducir más de un 90% el coste computacional respecto a la optimización heurística conveniconal obteniendo resultados muy similares. Esta tesis proporciona en primer lugar, una amplia revisión bibliográfica, tanto de los criterios utilizados para la valoración de la sostenibilidad en puentes como de los diferentes métodos de análisis de ciclo de vida para obtener un perfil completo de los pilares ambientales y sociales. Posteriormente, se define una metodología para la valoración completa de la sostenibilidad, usando métodos de análisis de ciclo de vida. Asimismo, se propone un enfoque que permite obtener estructuras poco influenciables por los parámetros estructurales, así como por las preferencias de los diferentes decisores frente a los criterios sostenibles. La metodología proporcionada en esta tesis es aplicable a cualquier otro tipo de estructura.
[CA] Actualment existeix una tendència cap a la sostenibilitat, especialment en els països desenrotllats on la preocupació de la societat pel deteriori ambiental i els problemes socials ha augmentat. Seguint aquesta tendència, el sector de la construcció és un dels sectors que major influència té a causa del seu alt impacte econòmic, ambiental i social. Al mateix temps, existeix un increment en la demanda de transport que provoca la necessitat de desenrotll i manteniment de les infraestructures necessàries per a tal fi. En tot açò, els ponts es converteixen en una estructura clau, i per tant, la valoració de la sostenibilitat al llarg de tota la seua vida és essencial. L'objectiu principal d'aquesta tesi doctoral és proposar una metodologia que permeta valorar la sostenibilitat d'un pont baix condicions inicials incertes (subjectivitat del decisor o variabilitat dels paràmetres inicials) i optimitzar el disseny per a obtenir ponts òptims robusts. Per a això, s'ha realitzat una extensa revisió bibliogràfica de tots els treballs en els quals es realitza un anàlisis de la sostenibilitat mitjançant la valoració de criteris relacionats amb els seus pilars principals (econòmic, ambiental o social). En aquesta revisió s'ha observat que la forma més completa de valorar els pilars ambientals i socials és mitjançant l'ús de mètodes d'anàlisis de cicle de vida. Aquests mètodes permeten realitzar la valoració de la sostenibilitat al llarg de totes les etapes de la vida dels ponts. Tot aquest procediment proporciona informació molt valuosa als decisors per a la valoració i selecció del pont més sostenible. No obstant això, les valoracions subjectives dels decisors sobre la importància dels criteris influeixen en l'avaluació final de la sostenibilitat. Per aquesta raó, és necessari crear una metodologia que reduïsca la incertesa associada i busque solucions robustes enfront de les opinions dels agents implicats en la presa de decisions. A més, el disseny i la presa de decisions en ponts està condicionat pels paràmetres inicialment definits. Açò condueix a solucions que poden ser sensibles front a menuts canvis en les dites condicions inicials. El disseny òptim robust permet obtenir dissenys òptims i estructuralment estables front a variacions de les condicions inicials, i també dissenys sostenibles i poc influenciables per les preferències dels decisors que formen part del procés de presa de decisió. D'aquesta manera, el disseny òptim robust es converteix en un procés d'optimització probabilística que requereix un gran cost computacional. Per aquest motiu, l'ús de metamodels s'ha integrat en la metodologia proposta. En concret, s'ha utilitzat l'hipercub llatí per a la definició de la mostra inicial i els models kriging per a la definició de l'aproximació matemàtica. D'aquesta forma, l'optimització heurística basada en kriging ha permés reduir més d'un 90% el cost computacional respecte a l'optimització heurística convencional obtenint resultats molt similars. Aquesta tesi doctoral proporciona en primer lloc, una ampla revisió bibliogràfica, tant dels criteris utilitzats per a la valoració de la sostenibilitat en ponts com dels diferents mètodes d'anàlisis de cicle de vida per a obtenir un perfil complet dels pilars ambientals i socials. Posteriorment, es defineix una metodologia per a la valoració completa de la sostenibilitat, utilitzant mètodes d'anàlisis de cicle de vida. Així mateix, es proposa un enfocament que permet obtenir estructures poc influenciables pels paràmetres estructurals, així com per les preferències dels diferents decisors enfront dels criteris sostenibles. La metodologia proporcionada en aquesta tesi doctoral és aplicable a qualsevol altre tipus d'estructura. Nº de páginas:
I would like to acknowledge the economic support of the Spanish Ministry of Economy and Competitiveness, formerly called Spanish Ministry of Science and Innovation. This thesis has been possible thanks to the FPI fellowship and the financially support of BRIDLIFE (Research Project BIA2014-56574-R) and DIMALIFE (Project BIA2017-85098-R).
Penadés Plà, V. (2020). Life-cycle sustainability design of post-tensioned box-girder bridge obtained by metamodel-assisted optimization and decision-making under uncertainty [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/147480
TESIS
Lüdtke, Timo Hans-Werner [Verfasser]. "Functional analysis of the T-box genes Tbx2 and Tbx3 in murine liver and lung development / Timo Hans-Werner Lüdtke." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2011. http://d-nb.info/1019566876/34.
Повний текст джерелаMinsart, Charlotte. "Involvement of High Mobility Group Box 1 protein in acetaminophen-induced liver injury: dissection of signaling pathways and potential therapeutic targeting." Doctoral thesis, Universite Libre de Bruxelles, 2021. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/319459.
Повний текст джерелаDoctorat en Sciences biomédicales et pharmaceutiques (Médecine)
info:eu-repo/semantics/nonPublished
Watkins, Sharon E. "Thinking Outside a Shifting Box: The Lived Experiences of Innovative Public High School Principals in an Era of High Stakes Accountability." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1480504598892723.
Повний текст джерелаPowers, Jennifer Robertson. "Reproductive Success of American Kestrels (Falco sparverius) Nesting in Boxes along an Interstate in Northeastern Tennessee." Digital Commons @ East Tennessee State University, 2009. https://dc.etsu.edu/etd/1787.
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