Дисертації з теми "Lipophilic drug"
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Quader, Sabina, and N/A. "Selective Synthetic Modification of Aminoglycosides for Drug Targeting to Tuberculosis." Griffith University. School of Biomolecular and Physical Sciences, 2007. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20071024.151619.
Повний текст джерелаNyakas, Claudia Verfasser], Karsten [Akademischer Betreuer] [Mäder, Reinhard H. H. [Akademischer Betreuer] Neubert, and Wolfgang J. [Akademischer Betreuer] Parak. "Polyelectrolyte nanocapsules as modern drug delivery system for lipophilic drug candidates / Claudia Nyakas. Betreuer: Karsten Mäder ; Reinhard Neubert ; Wolfgang J. Parak." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2012. http://d-nb.info/1025352858/34.
Повний текст джерелаDawoud, Mohamed [Verfasser], Alfred [Akademischer Betreuer] Fahr, Heike [Akademischer Betreuer] Bunjes, and Thomas [Akademischer Betreuer] Rades. "Investigations on the transfer of lipophilic drug models from lipid nanoparticles to lipophilic acceptor compartments using different techniques / Mohamed Dawound. Gutachter: Alfred Fahr ; Heike Bunjes ; Thomas Rades." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2011. http://d-nb.info/1016368259/34.
Повний текст джерелаVázquez, Lozano Javier. "On the usage of lipophilic descriptors for molecular similarity evaluation." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/667608.
Повний текст джерелаEl fet d'assumir que molècules estructuralment semblants donaran lloc a activitats biològiques similars ha estat una idea àmpliament explotada en el disseny de fàrmacs. Aquesta premissa subjau en la majoria de les aplicacions pràctiques en recerca química i farmacèutica. No obstant això, el concepte de similitud molecular és subjectiu i la seva interpretació pot variar segons l’ús que se’n vulgui derivar. La quantificació d’aquesta mesura de semblança molecular depèn de la representació de les característiques químiques presents en l'estructura molecular mitjançant descriptors 1D, 2D o 3D, la ponderació d'aquests descriptors i l'expressió matemàtica de la funció de similitud. En l’àmbit de les característiques químiques utilitzades en els mètodes tridimensionals de similitud molecular, les propietats electrostàtiques i estèriques han estat dominants tradicionalment. Tanmateix, això oculta el paper fonamental exercit per altres contribucions a l'afinitat d'unió, com els canvis en la (de)solvatació del lligant i del receptor. Malgrat la seva rellevància, la lipofilicitat ocupa aparentment un paper secundari com a descriptor principal del reconeixement lligand-receptor. Sota aquesta premissa s’ha desenvolupat una eina de cribratge virtual 3D basada en lligands (PharmScreen) que explota les relacions de similitud entre topologies hidrofòbiques derivades del model continuo de solvatació Miertus – Scrocco – Tomasi (MST). Els estudis reportats al llarg d’aquesta tesis recolzen la utilitat de les contribucions atòmiques a la lipofilicitat com a descriptors fonamentals en estudis de similitud, complementant la informació derivada dels descriptors tradicional. PharmScreen es presenta, així, com una eina competitiva per aplicar en campanyes de cribratge virtual basada en lligand o en combinació amb tècniques basades en proteïna, obrint una nova finestra en l’ampli espai químic.
Schuck, Virna Josiane Aurelio. "Use of microdialysis as a tool to determine tissue distribution of lipophilic and high molecular weight compounds." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0008003.
Повний текст джерелаTypescript. Title from title page of source document. Document formatted into pages; contains 139 pages. Includes Vita. Includes bibliographical references.
Eley, John Graham. "The incorporation of lipophilic agents into low density lipoprotein for drug targeting and evaluation as anticancer delivery systems." Thesis, University of Strathclyde, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278421.
Повний текст джерелаCroughton, Karen. "Novel pharmacology of the lipophilic antifolate methylbenzoprim." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368236.
Повний текст джерелаCheung, Wai-Han. "Novel steroidal metal complexes with potential pharmaceutical applications." Thesis, Loughborough University, 1992. https://dspace.lboro.ac.uk/2134/27879.
Повний текст джерелаDrooge, Dirk Jan van. "Combining the incompatible inulin glass dispersions for fast dissolution, stabilization and formulation of lipophilic drugs /." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2006. http://irs.ub.rug.nl/ppn/29297678X.
Повний текст джерелаKattner, Sven-Desiderius [Verfasser], Dagmar [Gutachter] Fischer, Gerhard [Gutachter] Scriba, and Oliver [Gutachter] Germershaus. "Entwicklung von PLGA-Nanopartikeln als Drug Delivery System für lipophile Wirkstoffe, die in die Arachidonsäurekaskade eingreifen / Sven-Desiderius Kattner ; Gutachter: Dagmar Fischer, Gerhard Scriba, Oliver Germershaus." Jena : Friedrich-Schiller-Universität Jena, 2020. http://d-nb.info/1223981711/34.
Повний текст джерелаHuffman, Jessica, Stacy D. Brown, Paul O. Lewis, Sarah Lawson, Amanda P. Ogle, and Gina Peacock. "Comparative Stability of Oral Vitamin K Liquids Stored in Refrigerated Amber Plastic Syringes." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/5323.
Повний текст джерелаDong, Wenyu [Verfasser]. "Multiparticulate drug delivery system for lipophilic drugs and macromolecule drugs / vorgelegt von Wenyu Dong." 2005. http://d-nb.info/977047547/34.
Повний текст джерелаLai, Hsien-Hung, and 賴憲宏. "Transdermal drug delivery enhanced and controlled by erbium:YAG laser: a comparative study of lipophilic and hydrophilic drugs." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/62596660089848678643.
Повний текст джерела台北醫學院
醫學研究所
89
The influence of an erbium:YAG laser on the transdermal delivery of drugs across skin was studied in vitro. Indomethacin and nalbuphine, which have the same molecular weight, were selected as model lipophilic and hydrophilic drugs respectively, to compare skin permeation by laser treatment. The results indicate a significant increase in the permeation of indomethacin and nalbuphine across skin pretreated with an erbium:YAG laser. The laser had a greater effect on the permeation of hydrophilic molecules which usually possess low permeability. The laser intensity and its spot size were found to play an important role in controlling transdermal delivery of drugs. Permeation of the hydrophilic drug increased following an increase of laser energy. On the other hand, a different result was observed for the lipophilic drug transported across laser-treated skin. The stratum corneum (SC) layer in skin could be partly ablated by the erbium:YAG laser. The barrier function of the SC may also be modulated by a lower intensity of the laser without affecting the viability and structure of the epidermis/dermis as determined by histological observations. However, ultrastructural alteration of the epidermis/dermis may be caused by laser treatment. Use of an erbium:YAG laser is a good method for enhancing transdermal absorption of both lipophilic and hydrophilic drugs, because it allows precise control of SC removal, and this ablation of SC can be reversible to the original normal status.
Thakur, Rashmi A. "Design of polymeric delivery system with targeted drug release profiles for hydrophilic and lipophilic compounds." 2008. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17228.
Повний текст джерелаChin-YuChung and 鍾覲羽. "PCOX Microneedles Containing Gelatin Microspheres as a Dual-Drug Release System for Transdermal Delivery of Hydrophilic and Lipophilic Drugs." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/60267786469584282636.
Повний текст джерела國立成功大學
化學工程學系
104
This study reports embeddable polycarbonate-co-polyoxalate (PCOX) microneedles (MNs) containing crosslinked gelatin microspheres (MPs) as a dual- drug transdermal delivery system for hydrophilic and hydrophobic drugs. In this system, hydrophobic model drugs, rhodamine 6G (Rh6G), was encapsulated within the MNs; whereas hydrophilic model drugs, nile blue, was loaded within the MPs. PCOX MNs were mounted to the top of a dissolvable poly(N- vinylpyrrolidone)/poly(vinyl alcohol) (PVP/PVA) supporting array, providing mechanical strength to fully insert the MNs into the skin. When inserted into the skin, the supporting array can be quickly dissolved by interstitial fluid, leaving the MNs within the skin for sustained drug delivery without requiring a transdermal patch. The gelatin MPs quickly swell to release nile blue because of contact with skin’s water. Such swelling will cause the MN disintegration, thus accelerating Rh6G release from the MNs. The gelatin MPs was prepared by utilizing W/O emulsion polymerization and then crosslinked with genipin solution for 6 h. When contact with water for 90 s, the diameter of the crosslinked MPs can swell to ~2 times their initial diameter (n = 10). The MNs were then prepared by filling a MN mold with nile blue-loaded MPs. These MNs have sufficient mechanical strength to be inserted into porcine and rat skins at a depth of 700~1000 μm. In vitro drug release study showed that nile blue can be quickly released from the MNs (~80% at Day 14). At Day 50, 100% of Rh6G was released from the group with MPs, whereas there is only 75% of Rh6G release from their counterpart. This indicated that MP swelling indeed enhances drug release from the MNs. Such release behavior can be also observed from the in vivo drug release study. These results demonstrated that the embeddable PCOX MNs with gelatin MPs, which enable to simultaneously release hydrophilic and hydrophobic drugs into the skin in a sustained manner, may be a new generation of transdermal delivery system.
Thwala, Lungile Nomcebo. "Preparation and characterization of alginate-chitosan nanoparticles as a drug delivery system for lipophilic compounds." Thesis, 2012. http://hdl.handle.net/10210/6192.
Повний текст джерелаDespite several decades of extensive research and development in pharmaceutical chemistry, the poor solubility of lipophilic compounds in aqueous media remains a major barrier to their absorption, bioavailability and clinical efficacy. This poor solubility is also a problem in other areas such as the flavour and fragrance industry. In cosmetics, for example, poor aqueous solubility and instability of oily compounds causes problems in formulation and fragrance stability. One approach to overcome these difficulties is to encapsulate oily compounds in biocompatible materials. As a drug delivery system such an approach is attractive if the size of the capsule is reduced to the micrometer or nanometer scale. Naturally occurring polysaccharides like sodium alginate (NaALG) and chitosan (CS) are generally regarded as safe (GRAS) for use in human use and have therefore gained much attention recently. As a drug delivery system, this polymer matrix can be used to prevent drug degradation in the gastro intestinal tract (GIT) and often provides controlled release of the encapsulant. Cyclodextrins (CDs) on the other hand offer an alternative approach. These cyclic oligosaccharides have the ability to form non-covalent inclusion complexes with a range of organic compounds, and in so doing alter their physiochemical properties such as solubility. This study was aimed at exploring these concepts by using ALG and CS as an entrapment matrix for an essential oil, tagette oil (used as a model oily drug) that is insoluble in aqueous media. Alginate/chitosan (ALG/CS) nanoparticles were prepared in a 3-step procedure; emulsification of tagette oil in aqueous Na-ALG solution, followed by ionotropic pre-gelation of the ALG core with CaCl2 and further crosslinking with CS. Morphology and particle size measurements were performed by scanning and transmission electron microscopy (SEM and TEM), and Malvern Zetasizer.
陳易齋. "STUDY OF THE EFFECT OF LIPID VEHICLE ON THE ABSROPTION OF LOW BIOAVAILABLE AND LIPOPHILIC DRUGS." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/62512033173128656307.
Повний текст джерелаZhu, Xiaoyi [Verfasser]. "Transfer of lipophilic drugs between liposomal membranes by using the ion-exchange micro-column technique and the fluorescence dequenching effect / von Xiaoyi Zhu." 2008. http://d-nb.info/993360122/34.
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