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Добірка наукової літератури з теми "Lipide de signalisation"
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Статті в журналах з теми "Lipide de signalisation"
Traynard, V., T. Thi Thu Tran, P. Besnard, N. Khan, H. Poirier, and I. Niot. "P059 Le lipido-récepteur intestinal CD36 et sa cascade de signalisation ERK1/2 dépendante contrôle la synthèse des chylomicrons." Cahiers de Nutrition et de Diététique 48 (December 2013): S86. http://dx.doi.org/10.1016/s0007-9960(13)70417-6.
Повний текст джерелаTraynard, V., T. Thi Thu Tran, P. Besnard, N. Khan, H. Poirier, and I. Niot. "P059 Le lipido-récepteur intestinal CD36 et sa cascade de signalisation ERK1/2 dépendante contrôle la synthèse des chylomicrons." Nutrition Clinique et Métabolisme 27 (December 2013): S86. http://dx.doi.org/10.1016/s0985-0562(13)70391-1.
Повний текст джерела"Lipid Synthesis, Transport, and Signalling / Lipides: synthèse, transport et signalisation." Biochemistry and Cell Biology 82, no. 1 (February 1, 2004): v. http://dx.doi.org/10.1139/o03-907.
Повний текст джерелаДисертації з теми "Lipide de signalisation"
Vaillancourt, Myriam. "Implication de la lipide phosphatase SHIP1 dans les voies de signalisation du CD32A dans le neutrophile humain." Thesis, Université Laval, 2005. http://www.theses.ulaval.ca/2005/22931/22931.pdf.
Повний текст джерелаMeuillet, Emmanuelle. "Effets des lipides membranaires sur la signalisation par les recepteurs aux facteurs de croissance : application a l'etude du mode d'action de la metformine." Strasbourg 1, 1995. http://www.theses.fr/1995STR15119.
Повний текст джерелаParadis, Sophie. "Implication du diacyglycérol pyrophosphate et des lipides phosphate phosphatases dans la signalisation de l'acide abscissique chez Arabidopsis thaliana." Paris 6, 2009. http://www.theses.fr/2009PA066531.
Повний текст джерелаWolf, Alexander. "A molecular toolbox to study the pleiotropic functions of phosphatidic acid in neurosecretion." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ033.
Повний текст джерелаNeurosecretion requires multiple proteins acting together to orchestrate transport, fusion and recycling of secretory vesicles. However, contribution of lipids, main components of cellular membranes, have been much less studied in these processes, primarily because of a lack of adequate tools. Hence, during my thesis, I implemented two novel approaches to study the pleiotropic functions of a peculiar signaling lipid: phosphatidic acid (PA). The use of chemically modified PA click-analogues enabled me to establish their dynamics as well as to characterize their interactome directly within neurosecretory cells. A second approach based on the optogenetic targeting of enzymes involved in the PA metabolism modulated its cellular levels with an unprecedented spatial and temporal resolution. This work allowed to unravel the non-redundant functions of various subcellular PA pools. Our novel molecular toolbox for PA, represents a breakthrough in lipid biology that will greatly improve our understanding of the roles of PA in the neurosecretory process
Violet, Pierre-Christian. "Rôle des lipides-phosphate phosphatases dans la modulation des voies de signalisation impliquées dans les léiomyomes utérins." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00788479.
Повний текст джерелаDesbourdes, Céline. "Nucléoside diphosphate kinase D : une protéine mitochondriale bifonctionnelle." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV004/document.
Повний текст джерелаThe nucleoside diphosphate kinases (NDPK) are essential for generation of nucleoside triphosphates (NTPs) using ATP and NDPs. The mitochondrial NDPK isoform (NDPK-D) located in the mitochondrial intermembrane space is found to have two modes of function. First, the phosphotransfer mode in which the protein has a kinase activity like other NDPK enzymes. In this mode, NDPK-D produces GTP for the optic atrophy 1 protein (OPA1), a GTPase involved in mitochondrial fusion, and ADP for the adenylate translocator (ANT) and the mitochondrial ATPase for ATP regeneration. The second mode of function is called lipid transfer and is related to the capacity of NDPK-D to bind anionic phospholipids, especially cardiolipin (CL). In this mode, the protein can cross-link the two mitochondrial membranes and transfer CL from the inner to the outer mitochondrial membrane, which can serve as a signal for mitophagy and apoptosis. This work aims to study these NDPK-D functions in more detail. With the use of HeLa cells stably expressing the wild-type, kinase inactive (H151N mutation) or lipid binding deficient (R90D mutation) NDPK-D and mouse lung epithelial cells, we show (i) the close proximity between NDPK-D and OPA1 that leads to GTP channeling from NDPK-D to OPA1, (ii) the essential role of NDPK-D for CL externalization to the mitochondrial surface during mitophagy, serving as a recognition signal for LC3-II-autophagosomes to eliminate damaged mitochondria, (iii) the possible inhibition of CL externalization due to the presence of NDPK-D/OPA1 complexes, and (iv) a pro-metastatic phenotype of HeLa cells expressing either of the NDPK-D mutants (H151N or R90D), characterized by high invasive and migratory potential, altered proteomic profile and changed mitochondrial network structure and function. Finally, a first bacterial expression and purification strategy for full-length OPA1 has been established for future in vitro studies of NDPK-D/OPA1 complexes
Harchouni, Seddik. "Manipulation des voies de signalisation de l'énergie pour améliorer la production des biocarburants chez les organismes photosynthétiques." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0498.
Повний текст джерелаTriacylglycerol (TAG) is a highly energetic metabolite that can be easily converted into biodiesel. TAG can be produced from both plants and microalgae. However, plants have low TAG yields in their dominant vegetative tissues. Microalgae can accumulate high amounts of TAG, but only under stress, leading to growth inhibition and limiting yield. The study and manipulation of stress and energy signaling pathways can offer new strategies to improve biomass and TAG accumulation without compromising growth. In this thesis, I studied the role of two major energy signaling pathways: the guanosine penta(tetra) phosphate (ppGpp) pathway in the chloroplast and the target of rapamycin (TOR) pathway in the cytosol. I chose to work on the moss Physcomitrella patens which is an interesting model of photosynthetic eukaryote because of its evolutionary position between algae and vascular plants. To study the role of ppGpp we created transgenic lines that inducibly express a ppGpp synthase and over-accumulate ppGpp. I found that ppGpp accumulation causes a strong inhibition of photosynthetic capacity due to the inhibition of the expression of key chloroplast encoded proteins, and also reorganization of the thylakoid membrane system into super grana. For the TOR pathway, we treated P. patens protonema with active site TOR inhibitors and showed that this cause growth inhibition in a dose dependent manner and is accompanied by TAG accumulation. The use of lipid dyes reveals a shift from small growth associated vesicles to a larger oil body structures after treatment. Further studies will allow the development of new strategies for improving biofuel production in photosynthetic organisms
Grosjean, Kevin. "Microdomaines ordonnés de la membrane plasmique végétale : caractérisation et rôle dans la signalisation associée à la défense." Thesis, Dijon, 2015. http://www.theses.fr/2015DIJOS089/document.
Повний текст джерелаRecent studies have shown the existence of lateral sub-compartmentalization of plant plasmamembrane similar to that of animal cells and yeasts. The aim of this thesis was to provide newelements to characterize this compartmentalization (physical properties of specific domains,mechanisms of their formation, determination of their size, etc...) and to study its role in thephysiology of plant cells.The development spectral confocal microscopy coupled with the use of an environment-sensitiveprobe enabled to obtain the first description at the submicron scale of plasma membrane organizationinto domains exhibiting various physical properties. These domains coexist at the plasma membranesurface of tobacco suspension cells as well as the membrane of vesicles composed of models lipids orcell plasma membrane lipids, purified plasma membrane vesicles, and protoplasts. However,differences in the lateral organization observed in these membranes have shown the importance ofphytosterols which are, through specific interactions with neighboring plant lipids such as GIPCs,essential for local formation of ordered domains. The huge diversity of plant lipids drives thecompartmentalization of the plasma membrane allowing the dynamic segregation of membranecomponents. Sterols greatly increase membrane order, whereas proteins tends to decrease it.Cytoskeleton and cell wall do alter neither presence nor organization of ordered domains of the plasmamembrane. We have also shown that the organization of these domains is transiently modified duringthe early stages of defense signaling cascade. In fact, we have identified changes in overall physicalproperties and fine lateral organization of the membrane caused by various elicitors of defensereactions, including cryptogein, a protein secreted by the oomycete Phytophthora cryptogea. We haveshown that these changes are a generic element of defense signaling cascade and depend onphosphorylation processes; oxidative burst being also a major actor of the control of the increase ofmembrane order observed during the very early stages of the signalling process. Cryptogein, whichexhibits the particular ability to trap sterols, also showed a specific capacity to increase membranefluidity and amplify the intensity of the signalling cascade, as measured by the production of reactiveoxygen species.These results open new perspectives in the understanding of cell-elicitin interactions and provide anew view on the central role of sterol composition in the lateral organization of plant plasmamembrane. They also identify membrane dynamics as a new player in the signalling cascade occurringduring plant defense
Dramane, Gado. "Etude de la signalisation calcique dans les cellules gustatives lipidiques chez la souris." Thesis, Dijon, 2012. http://www.theses.fr/2012DIJOS035/document.
Повний текст джерелаThe lipid-binding glycoprotein CD36, expressed by circumvallate papillae (CVP) of the mouse tongue, has been shown to be implicated in oro-gustatory perception of dietary lipids. We demonstrate that linoleic acid (LA) by activating sPLA2, cPLA2 and iPLA2 via CD36, produced arachidonic acid (AA) and lyso-phosphatidylcholine (Lyso-PC) which triggered Ca2+ influx in CD36-positive taste bud cells (TBC), purified from mouse CVP. LA induced the production of Ca2+ influx factor (CIF). CIF, AA and Lyso-PC exerted different actions on the opening of store-operated Ca2+ (SOC) channels, constituted of Orai proteins and regulated by STIM1, a sensor of Ca2+ depletion in the endoplasmic reticulum. We used siRNA technology and transgenic mice models and observed that CIF and Lyso-PC opened Orai1 channels whereas AA-opened Ca2+ channels were composed of Orai1/Orai3. STIM1 was found to regulate LA-induced CIF production and opening of both kinds of Ca2+ channels. Furthermore, Stim1–/– mice lost the spontaneous preference for fat, observed in wild-type animals. The CD36-positive TBC from Stim1–/– mice also failed to release serotonin into extracellular environment. Our results suggest that fatty acid-induced Ca2+ signaling, regulated by STIM1 via CD36, might be implicated in oro-gustatory perception of dietary lipids and the spontaneous preference for fat
Platre, Matthieu. "Localisation et fonction des lipides anioniques dans l'organisation cellulaire et le développement des plantes." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEN098.
Повний текст джерелаThe « electrostatic territory» is part of the eukaryotic membrane organization and is defined by the enrichment of negatively charged phospholipids at the membrane cytosolic face. This feature is involved in the membrane recruitment of cytosolic proteins, which contain positively charged motifs and/or domains. In this work, we used Arabidopsis thaliana as a model and explored the existence of an electrostatic territory in plant cells. We found that the plasma membrane is the most anionic intracellular membrane (Simon, Platre et al., 2016 Nature Plants). This electrostatic field is maintained by lipid cooperation between, phosphatidic acid, phosphatidylserine and phosphatidylinositol-4-phosphate. The cell surface unique feature is involved in the regulation of hormonal signalling such as auxin and brassinosteroids pathways. We found that phosphatidylserine tunes the spatiotemporal dynamics of small GTPases from the Rho family. During auxin response, PS is required to cluster Rho into specialized membrane domains. We show that nanocluster formation is required for Rho-mediated auxin signaling including the regulation of endocytosis, cytoskeleton organization, morphogenesis and the root gravitropic response