Дисертації з теми "Lineage decision"
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Meng, Lingzhang [Verfasser]. "The impact of B-lineage derived IL-10 on fate decision of monocyte differentiation / Lingzhang Meng." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2016. http://d-nb.info/1096832577/34.
Повний текст джерелаChain, Jennifer Lee. "Elucidating the mechanisms of the human [alphabeta] vs. [gammadelta] lineage decision and the details of [gammadelta] thymocyte development." Oklahoma City : [s.n.], 2005.
Знайти повний текст джерелаBröske, Ann-Marie Elisabeth. "The level of DNA methylation impacts self-renewal capacity and lineage choices of hematopoietic stem cells." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16099.
Повний текст джерелаDNA methylation is one of the major epigenetic mechanisms which is known to play a role in embryonic stem cell fate, but its function in somatic stem cells is not well understood. In this thesis two different genetic mouse models were chosen to address the role of DNA methyltransferase 1 (DNMT1) controlled DNA methylation in adult hematopoiesis. First, a conditional knockout approach was used to delete DNMT1 in the adult hematopoietic system. Second, DNMT1 hypomorphic mice with reduced DNMT1 expression were analyzed. Complete DNMT1 deletion in hematopoietic cells led to severe cytopenia and anemia causing rapid lethality of all animals. Bone marrow analysis revealed an almost complete absence of hematopoietic stem and progenitor cells in DNMT1 ablated primary mice as well as in secondary chimeric mice. These results indicated that DNMT1 controlled maintenance of DNA methylation is indispensable for HSCs preservation and differentiation. In contrast to complete DNMT1 deletion, mice with hypomorphic DNMT1 expression were viable, but showed low methylation levels in multiple tissues including the hematopoietic system. Detailed phenotypical and functional analysis of the hypomethylated hematopoietic stem cell (HSCs) compartment revealed an impaired homeostasis and self-renewal capacity. Intriguingly, mutant animals had profoundly reduced lymphoid cell compartments, whereas myeloid and erythroid compartments were unchanged. Expression profiling of stem and myeloid progenitor cells unexpectedly demonstrated that reduced DNA methylation forces the HSC to adopt a myeloid lineage identity. These results, showing the inability of hypomethylated HSCs to maintain an undifferentiated state, provided an explanation for their disturbed capability to self-renew and produce lymphocytes. Taken together, these findings suggest that distinct levels of DNA methylation are required to control different functional programs such as self-renewal and alternative lineage choices in HSCs, thus uncovering a previously unrecognized function for DNMT1 activity.
Di, Tullio Alessandro 1982. "Reprogramming of B cells into macrophages: mechanistic insights." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/85722.
Повний текст джерелаRecientemente, nuestro grupo ha demostrado que las células pre-B se pueden reprogramar a macrófagos mediante la sobreexpresión del factor de transcripción C/EBP, con una eficiencia elevada. Así mismo, mediante la expresión de la forma inducible de C/EBP en una línea de células pre-B (C11), éstas también se puede convertir en células similares a macrófagos. Usando este sistema hemos estudiado si durante el proceso de trans-diferenciacion las células requieren volver a un estadio de célula precursora, y si el ciclo celular es necesario para este proceso. En cuanto a la primera cuestión, el análisis del transcriptoma de células trans-diferenciadas mostró que la expresión de la mayoría de los genes están regulados durante todo el proceso bien aumentando o disminuyendo, y que adquieren el fenotipo de macrófago a los 5 días después de iniciar el proceso. Así mismo, se observó la reactivación transitoria de un grupo de genes que codifican para marcadores de células mieloides inmaduras; también cabe destacar que observamos una disminución en la expresión de los genes expresados en células progenitoras Kit y Flt3, así como de genes de linajes impropios. Es importante destacar que nunca hemos llegado a observar la expresión de combinaciones de marcadores de superficie característicos de las células madre hematopoyéticas y las células progenitoras (HSPCs), incluyendo c-Kit y Flt3, mediante el análisis por citometría de flujo. Estos resultados se reprodujeron incluso cuando C/EBP se sobreexpresó en células pre-B que fueron cultivadas en condiciones que favorecen el crecimiento de las HSPC o cuando el factor de transcripción se activó de forma limitada en el tiempo. En cuanto a la segunda pregunta, usando la línea de células inducibles pre-B C11, el análisis mediante microscopia a diferentes tiempos después de la inducción de la reprogramación mostraron que una subpoblación de aproximadamente el 8% de las células pre-B no se dividen antes de adquirir las propiedades de macrófago, mientras que la mayoría de las células se dividen sólo una vez y un pequeño porcentaje dos veces antes de que se reprogramen totalmente a macrófagos. De acuerdo con estos resultados se encontró que un 8% de las células inducidas no incorporan BrdU durante la reprogramación. Es importante destacar que el subconjunto de células que no se dividen expresan los niveles más altos de C/EBP, con lo que cabe pensar que la adquisición del fenotipo de macrófago es más rápida en estas células. La inhibición de la síntesis de ADN por afidicolina bloqueó la transdiferenciación en mas de un 70% de las células, lo que sugiere que la correcta progresión del ciclo celular es un requisito para la transdiferenciación. Sin embargo, al separar la linea de células pre-B C11 en fracciones G0/G1 y G2/M seguido de la inducción, la cinética de la reprogramación no mostró diferencias significativas. Por último, también demostramos que la reducción en la expresión de p53 en las células pre-B inducibles no altera el proceso de conversión a macrófago, lo que sugiere que la aceleración del ciclo celular no tiene ningún efecto. En conjunto, nuestros resultados muestran que la conversión de células pre-B a macrófagos no requiere retro-diferenciación y que las células con una expresión mayor de C/EBP pueden llegar a prescindir de la dependencia del ciclo celular para la trans-diferenciación de las células inmunitarias.
Morgani, Sophie Maria. "Signalling and transcriptional regulation of early developmental lineage decisions." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9660.
Повний текст джерелаKoutsoukis, Nikitas-Spiros. "Decision modelling and information systems : the interaction of information and decision technologies." Thesis, Brunel University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263519.
Повний текст джерелаBraathen, Jørgen, and Anders Lund Eriksrud. "Hydropower Bidding Using Linear Decision Rules." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for industriell økonomi og teknologiledelse, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-24844.
Повний текст джерелаMendes, Mirian Patricia Sanches. "Aplicação da programação linear na decisão económica de investimento." Master's thesis, Instituto Politécnico de Setúbal. Escola Superior de Ciências Empresariais, 2014. http://hdl.handle.net/10400.26/7883.
Повний текст джерелаConsiderando o atual contexto empresarial, que se caracteriza por uma elevada competitividade a nível global, é essencial que os gestores tomem decisões que contribuam para criação de valor e para a sustentabilidade competitiva das empresas. Assim, o objetivo desta dissertação de mestrado é evidenciar que a programação linear pode contribuir para a maximização da criação de valor, através da sua utilização no estudo das decisões económicas de investimento das empresas. Tais decisões acarretam riscos elevados porque condicionam a capacidade de produção e o tipo de vantagens competitivas a criar e, por isso, devem ser capazes de responder ao nível de crescimento esperado do mercado e aos fatores críticos de sucesso dos negócios. Para além disso, são decisões que envolvem normalmente montantes avultados de capitais e que exigem a entrada de dinheiro por parte dos proprietários e a negociação de fontes de financiamento de médio e longo prazo que irão condicionar durante muito tempo a tesouraria da empresa. Como tal, este trabalho de investigação pretende, através da realização de um estudo de caso sobre uma empresa de serviços, evidenciar que a programação linear poderá dar um forte contributo sobre a otimização deste tipo de decisões. O trabalho é constituído por duas partes principais. A primeira contém uma revisão bibliográfica dos principais assuntos abordados, tanto ao nível dos conceitos financeiros como da programação linear. A segunda parte, relativa ao estudo empírico, é constituída pelo capítulo 3, onde são descritos mais em pormenor os objetivos e a metodologia de investigação utilizada e pelo capítulo 4 onde é desenvolvido o estudo de caso. Por fim, ainda são apresentadas as principais conclusões sobre o trabalho desenvolvido. Ao nível dos resultados de investigação obtidos, demonstra-se que através da aplicação da programação linear é possível maximizar os cash-flows anuais, através da determinação do mix de serviços que a empresa deve oferecer, considerando os preços de venda, a estrutura de custos e de ativos, bem como a capacidade dos recursos existentes (Horas/Homem de cada tipo de serviço a realizar).
Considering the current business environment that is characterized by high global competitiveness, it is essential that managers make decisions that contribute to value creation and competitive sustainability of companies. Thus, the objective of this thesis is to show that linear programming can contribute to the maximization of value creation through their use in the study of economic investment decisions of companies. Such decisions entail high risks, because they limited the capacity and the type of competitive advantages to create, and therefore must be able to respond to the expected level of market growth and to the critical factors of business success. Furthermore those decisions usually involve large amounts of capital and require entry of money by owners and the negotiation of medium and long term funding sources that will limit for a long time the treasure of the company. As such, this research work intends to show, by conducting a case study on a service company, that linear programming can make a strong contribution on the optimization of these kinds of decisions. The thesis consists of two mains parts. The first part contains a literature review of the main issues discussed both to the concept of financial and linear programming. The second part on the empirical study is composed by chapter 3 where described in more detail the objectives and the methodology used, and chapter 4 where the case study is developed. In relation to the results of the investigation, it is demonstrated that by applying linear programming it is possible to maximize the annual cash flows, by determining the mix of services that the company should offer, considering the sales prices, the structure of costs and assets, as well as the capacity of existing resources (hours/man of each type of service to be attain).
Patrascu, Relu-Eugen. "Linear Approximations For Factored Markov Decision Processes." Thesis, University of Waterloo, 2004. http://hdl.handle.net/10012/1171.
Повний текст джерелаSpiropoulos, Takis. "Decision support for management using Bayes linear influence diagrams." Thesis, University of Sunderland, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259788.
Повний текст джерелаShcherban, V. Yu. "Algorithmic and programmatic providing decision systems of linear equalizations." Thesis, Київський національний університет технологій та дизайну, 2019. https://er.knutd.edu.ua/handle/123456789/14586.
Повний текст джерелаNadal, Roig Esteve. "Optimization models forimproving the decision-making in the pig production process under a Pig Supply Chain context." Doctoral thesis, Universitat de Lleida, 2019. http://hdl.handle.net/10803/669206.
Повний текст джерелаEsta tesis se centra en la estructura de cadena de suministro planteada en el sector porcino donde las pequeñas empresas y los productores de cerdos están integrados verticalmente, se especializan y trabajan juntos bajo el paraguas de grandes empresas o cooperativas. Estas cadenas de suministro tienen ventajas competitivas. Sin embargo, los gerentes deben considerar los nuevos problemas inexistente hasta ahora. Por tanto, esta tesis desarrolla un conjunto de modelos de decisión basados en Optimización para ayudar en el proceso de toma de en 1) Balancear el impacto de las emisiones en el sistema de producción porcina mediante el desarrollo de un modelo de decisión bajo una perspectiva económica 2) desarrollar un modelo de decisión multiperíodo y multigranja para la planificación de la producción teniendo en cuenta las características del proceso de producción, y 3) desarrollar un modelo de decisión para planificar decisiones tácticas en el proceso de producción de cerdos para aumentar la eficiencia. Esta tesis demuestra que el uso de modelos desarrollados brinda beneficios en el proceso de toma de decisiones, enfatiza la complejidad computacional de modelar un sistema integrado y abre nuevas oportunidades de investigación en el sector porcino.
This thesis focuses on the structure of supply chain raised in the pig sector where small pig companies and producers are vertically integrated, specialized and work together under the umbrella of large companies or cooperatives. These supply chains have competitive advantages. However, managers have to consider the new problems. Therefore, this thesis develops a set of decision-making models based on Optimization to help in the decision-making process to 1) Balance the impact of emissions on the pig production system by developing a decision model under a economic perspective 2) Develop a multi-period and multisite decision model for production planning taking into account the characteristics of the production process, and 3) develop a decision model to plan tactical decisions in the pig production process for increasing the efficiency. This thesis shows that the use of developed models provides benefits in the decision-making process, emphasizes the complexity of computing modeling an integrated system and opens new research opportunities in the pig sector.
Makaya, Makaya L. "Interactive methods for multiple objective linear programming in decision support." Master's thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/4385.
Повний текст джерелаBromberger, Martin [Verfasser], and Christoph [Akademischer Betreuer] Weidenbach. "Decision procedures for linear arithmetic / Martin Bromberger ; Betreuer: Christoph Weidenbach." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1207833657/34.
Повний текст джерелаSharp, Leslie L. "Studies on the role of the erk MAPK pathway in thymocyte lineage commitment decisions /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p9944213.
Повний текст джерелаTorcal, Garcia Guillem 1991. "Methylation of a lineage-instructive transcription factor acts as a cell fate switch." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2022. http://hdl.handle.net/10803/673532.
Повний текст джерелаLos factores de transcripción instructores de linaje orquestan decisiones de identidad celular a través de la regulación de programas de expresión génica. Sin embargo, cómo su función está regulada durante el desarrollo todavía se desconoce. C/EBPα es un factor de transcripción que juega un papel clave en varias decisiones de identidad celular, incluyendo mielopoiesis, adipogénesis y el desarrollo embrionario temprano. La metiltransferasa de argininas Carm1 también está involucrada en los mismos procesos, pero todavía no se ha descrito una posible conexión con C/EBPα. En esta Tesis, hemos investigado la conexión entre éstas dos proteínas en decisiones de identidad celular. Hemos descubierto que la arginina 35 de C/EBPα es un blanco clave para la metilación por Carm1, y está modificación postraduccional altera las propiedades biológicas del factor y actúa como un interruptor de identidad celular en mielopoiesis, adipogénesis y en la primera decisión entre pluripotencia y trofectodermo en el embrión.
Wolff-Piggott, Timothy. "Identifying predictors of evolutionary dispersion with phylogeographic generalised linear models." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25651.
Повний текст джерелаPark, Jin Won. "Simulation optimization with discrete decision variables and a single linear constraint /." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487329662145114.
Повний текст джерелаKamali, Aslan. "Developing a Decision Making Approach for District Cooling Systems Design using Multi-objective Optimization." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-208228.
Повний текст джерелаDie Energieverbrauchsraten haben in den letzten Jahrzehnten auf globaler Ebene dramatisch zugenommen. Diese Erhöhung ist zu einem großen Teil in den jüngst hohen Temperaturniveaus, vor allem in der Sommerzeit, begründet, die einen starken Anstieg der Nachfrage nach Klimaanlagen verursachen. Solche Ereignisse sind deutlich in Entwicklungsländern zu beobachten, vor allem in heißen Klimaregionen, wo Menschen vor allem konventionelle Klimaanlagensysteme benutzen. Diese Systeme verfügen meist über eine ineffiziente Leistungsfähigkeit und wirken sich somit negativ auf die Umwelt aus, was wiederum zur globalen Erwärmung beiträgt. In den letzten Jahren ist die Nachfrage nach Stadt- oder Fernkältetechnologien und -Netzwerken als Alternative zu konventionellen Systemen aufgrund ihrer höheren Effizienz und besseren ökologischen Verträglichkeit satrk gestiegen. Ein effizientes Design für Fernkühlsysteme zu erhalten, ist allerdings eine komplexe Aufgabe, die die Integration einer breite Palette von Kühltechnologien, verschiedener Konfigurationsmöglichkeiten von Netzwerk-Layouts und unterschiedlicher Energiequellen erfordert. Hierfür ist das Treffen kritischer Entscheidungen hinsichtlich einer Vielzahl von Möglichkeiten, Optionen und Technologien unabdingbar. Das Hauptziel dieser Arbeit ist es, ein Werkzeug zu entwickeln, das vorläufige Design-Konfigurationen und Betriebsmuster für Fernkälteenergiesysteme liefert, indem aureichend detaillierte Optimierungen durchgeführt werden. Zudem soll auch ein Ansatz zur Entscheidungsfindung vorgestellt werden, der Entscheidungsträger in einem frühen Planungsstadium bei der Bewertung städtischer Kühlungssysteme hinsichtlich der wirtschaftlichen Aspekte und Umweltleistung unterstützen soll. Unterschiedliche Aspekte dieser Problemstellung wurden in der Literatur von verschiedenen Forschern untersucht. Eine kurze Analyse des derzeitigen Stands der Technik ergab, dass mathematische Programmiermodelle die am weitesten verbreitete und erfolgreichste Methode für die Konfiguration und Gestaltung von Kühlsystemen für städtische Gebiete sind. Ein weiteres Ergebnis der Analyse war die Festlegung von Mehrzieloptimierungs-Modelles für die Unterstützung des Entscheidungsprozesses. Darauf basierend wurde im Rahmen der vorliegenden Arbeit ein Mehrzieloptimierungs-Modell für die Lösung des komplexen Entscheidungsfindungsprozesses bei der Gestaltung eines Kühlsystems für ein Stadtgebiet oder einen Bezirk entwickelt. Das Modell zielt darauf ab, mehrere Elemente des Kühlsystems zu optimieren, wie beispielsweise Kühlnetzwerke, Kühltechnologien sowie Kapazität und Lage der Systemtechnik. Zusätzlich werden verschiedene Energiequellen, auch solare wie Solarkonzentratoren, Vakuum-Solarkollektoren und PV-Module, berücksichtigt. Das Modell wurde auf Basis der gemischt-ganzzahlig linearen Optimierung (MILP) entwickelt und in GAMS Sprache implementiert. Zwei Fallstudien wurden mit dem entwickelten Modell untersucht. Die erste Fallstudie besteht aus sieben Gebäuden, die ein Wohnviertel darstellen, während die zweite Fallstudie einen Universitätscampus dominiert von Nichtwohngebäuden repräsentiert. Die Untersuchung wurde für mehrere Gruppen von Szenarien durchgeführt, wobei bestimmte Designparameter und Betriebsbedingungen überprüft werden, wie zum Beispiel die zur Verfügung stehende Fläche, Lage der Kühlanlage, örtliche Restriktionen der Kältespeicherung, Rohrpreise, Investitionskosten, konstante und variable Stromtarife, Strategie zur Einbindung der Solarenergie, Verfügbarkeit von Abwärme, Strategien der Lastenverschiebung, und die Wirkung der Außentemperatur in heißen Regionen auf die Leistung des Kühlsystems. Die Untersuchung bestand aus drei Stufen, wobei die jährlichen Gesamtkosten und die CO2-Emissionen die erste und zweite Einzelzieloptimierungsstufe darstellen. Die dritte Stufe war ein Pareto-Optimierung, die die beiden ersten Ziele kombiniert. Im Anschluss wurden nicht-dominante Lösungen, also Pareto-Lösungen, erzeugt, indem mehrere Pareto-Optimierungs-Szenarien basierend auf den Präferenzen der Entscheidungsträger abgebildet wurden. Schließlich wurde ein Ansatz zur Entscheidungsfindung entwickelt, um Entscheidungsträger bei der Auswahl einer bestimmten Lösung zu unterstützen, die am besten den Präferenzen des Planers oder des Entscheidungsträgers enstpricht, basierend auf der Differenz der Utopia und Nadir Werte, d.h. der jährlichen Gesamtkosten und CO2-Emissionen, die Ergebnis der einzelnen Optimierungsstufen sind
Chan, Ka Hou. "Bayesian methods for solving linear systems." Thesis, University of Macau, 2011. http://umaclib3.umac.mo/record=b2493250.
Повний текст джерелаTandberg, Caroline, and Signy Elde Vefring. "The linear decision rule approach applied to the hydrothermal generation planning problem." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for industriell økonomi og teknologiledelse, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-20963.
Повний текст джерелаRodgers, Philip D. "A linear programming based decision support aid for Navy enlisted strength planning." Thesis, Monterey, California. Naval Postgraduate School, 1991. http://hdl.handle.net/10945/43744.
Повний текст джерелаA multi-objective linear program (MOLP) using goal programming is developed as a decision support aid in determining optimal levels of those areas of Navy enlisted strength planning which are subject to centralized management control. Over a multi-year period these decisions include monthly inventories in each paygrade, monthly total inventories, monthly advancements in the top six paygrades, and monthly recruiting goals. The model incorporates the various budgetary, Congressional, and internal Navy force structure constraints inherent in the strength planning process while minimizing deviations from desired inventory goals, ensuring inventory stability, and determining optimal recruiting goals.
Anderson, Russell Kay. "Decision support for multi-objective linear programming using an interactive graphic presentation." Diss., The University of Arizona, 1994. http://hdl.handle.net/10150/186950.
Повний текст джерелаSohul, Munawwar Mahmud. "PERFORMANCE OF LINEAR DECISION COMBINER FOR PRIMARY USER DETECTION IN COGNITIVE RADIO." OpenSIUC, 2011. https://opensiuc.lib.siu.edu/theses/705.
Повний текст джерелаFernandes, Carlos Alexandre Rolim. "EqualizaÃÃo adaptativa e autodidata de canais lineares e nÃo-lineares utilizando o algoritmo do mÃdulo constante." Universidade Federal do CearÃ, 2005. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=2041.
Повний текст джерелаEste trabalho trata da proposiÃÃo de algoritmos para equalizaÃÃo cega de canais lineares e nÃao-lineares inspirados no Algoritmo do MÃdulo Constante (CMA). O CMA funciona de maneira bastante eficiente com constelaÃÃes nas quais todos os pontos possuem a mesma amplitude, como em modulaÃÃes do tipo Phase Shift Keying (PSK). Entretanto, quando os pontos da constelaÃÃo podem assumir diferentes valores de amplitudes, como em modulaÃÃes do tipo Quadrature Amplitude Modulation (QAM), o CMA e seus derivados muitas vezes nÃo funcionam de forma satisfatÃria. Desta forma, as tÃcnicas aqui propostas sÃo projetadas para melhorar a performance do CMA em termos de velocidade de convergÃncia e precisÃo, quando operando em sinais transmitidos com diversos mÃdulos, em particular para a modulaÃÃo QAM. Assim como o CMA, para possuir um bom apelo prÃtico, essas tÃcnicas devem apresentar bom compromisso entre complexidade, robustez e desempenho. Para tanto, as tÃcnicas propostas utilizam o Ãltimo sÃmbolo decidido para definir uma estimaÃÃo de raio de referÃncia para a saÃda do equalizador. De fato, esses algoritmos podem ser vistos como generalizaÃÃes do CMA e de alguns derivados do CMA para constelaÃÃes com mÃltiplos raios. A proposiÃÃo de algoritmos do tipo gradiente estocÃstico à concluÃda com o desenvolvimento de tÃcnicas originais, baseadas no CMA, para equalizaÃÃo de canais do tipo Wiener, que consiste em um filtro linear com memÃria, seguido por um filtro nÃo-linear sem memÃria. As expressÃes para a adaptaÃÃo do equalizador sÃo encontradas com o auxÃlio de uma notaÃÃo unificada para trÃs diferentes estruturas: i) um filtro de Hammerstein; ii) um filtro de Volterra diagonal; e iii) um filtro de Volterra completo. Um estudo teÃrico acerca do comportamento do principal algoritmo proposto, o Decision Directed Modulus Algorithm (DDMA) à realizado. SÃo analisadas a convergÃncia e a estabilidade do algoritmo atravÃs de uma anÃlise dos pontos de mÃnimo de sua funÃÃo custo. Outro objetivo à encontrar o valor teÃrico do Erro MÃdio QuadrÃtico MÃdio em Excesso - Excess Mean Square Error (EMSE) fornecido pelo DDMA considerando-se o caso sem ruÃdo. Ao final, à feito um estudo em que se constata que o algoritmo DDMA possui fortes ligaÃÃes com a soluÃÃo de Wiener e com o CMA. VersÃes normalizadas, bem como versÃes do tipo Recursive Least Squares (RLS), dos algoritmos do tipo gradiente estocÃstico estudados sÃo tambÃm desenvolvidas. Cada famÃlia de algoritmos estudada fie composta por quatro algoritmos com algumas propriedades interessantes e vantagens sobre as tÃcnicas clÃssicas, especialmente quando operando em sinais QAM de ordem elevada. TambÃm sÃo desenvolvidas versÃes normalizadas e do tipo RLS dos algoritmos do tipo CMA estudados para equalizaÃÃo de canais nÃo-lineares. O comportamento de todas as famÃlias de algoritmos desenvolvidos à testado atravÃs de simulaÃÃes computacionais, em que à verificado que as tÃcnicas propostas fornecem ganhos significativos em desempenho, em termos de velocidade de convergÃncia e erro residual, em relaÃÃo Ãs tÃcnicas clÃssicas.
This work studies and proposes algorithms to perform blind equalization of linear and nonlinear channels inspired on the Constant Modulus Algorithm (CMA). The CMA works very well for modulations in which all points of the signal constellation have the same radius, like in Phase Shift Keying (PSK) modulations. However, when the constellation points are characterized by multiple radii, like in Quadrature Amplitude Modulation (QAM) signals, the CMA does not work properly in many situations. Thus, the techniques proposed here are designed to improve the performance of the CMA, in terms of speed of convergence and residual error, when working with signals transmitted with multiple magnitude, in particular with QAM signals. As well as for the CMA, these techniques should have a good compromise among performance, complexity and robustness. To do so, the techniques use the last decided symbol to estimate reference radius to the output of the equalizer. In fact, they can be seen as modifications of the CMA and of some of its derivatives for constellations with multiple radii. The proposition of stochastic gradient algorithms is concluded with the development of new adaptive blind techniques to equalize channels with a Wiener structure. A Wiener filter consists of a linear block with memory followed by a memoryless nonlinearity, by using the CMA. We develop expressions for the adaptation of the equalizer using a unified notation for three different equalizer filter structures: i) a Hammerstein filter, ii) a diagonal Volterra filter and iii) a Volterra filter. A theoretical analysis of the main proposed technique, the Decision Directed Modulus Algorithm (DDMA), is also done. We study the convergence and the stability of the DDMA by means of an analysis of the minima of the DDM cost function. We also develop an analytic expression for the Excess Mean Square Error (EMSE) provided by the DDMA in the noiseless case. Then, we nd some interesting relationships among the DDM, the CM and the Wiener cost functions. We also develop a class of normalized algorithms and a class of Recursive Least Squares (RLS)-type algorithms for blind equalization inspired on the CMA-based techniques studied. Each family is composed of four algorithms with desirable properties and advantages over the original CM algorithms, specially when working with high-level QAM signals. Normalized and RLS techniques for equalization of Wiener channels are also developed. The behavior of the proposed classes of algorithms discussed is tested by computational simulations. We verify that the proposed techniques provide significative gains in performance, in terms of speed of convergence and residual error, when compared to the classical algorithms.
Laing, Adam. "TLE proteins in mouse embryonic stem cell self renewal and early lineage specification." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5729.
Повний текст джерелаGibbin, Randal Victor. "Modelos para escolha de cultivares em empreendimentos agricolas de pequeno porte." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/263460.
Повний текст джерелаDissertação (mestrado profissional) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecanica
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Resumo: Neste trabalho procurou-se desenvolver uma ferramenta de suporte à decisão para a seleção de cultivares de Citrus em uma fazenda em fase de implantação localizada em Porto Ferreira/SP. Foram utilizadas as técnicas de Programação Linear para a seleção de cultivares e a Análise de Retorno Esperado para o auxílio na determinação da estimativa de retorno do investimento. Foram determinadas sugestões de ocupação do empreendimento através de três modelos em programação linear, dos quais um foi desenvolvido em programação inteira, os modelos trabalharam com sete cultivares de Citrus desempenhando o papel de variáveis e com restrições de investimento total em insumos, mão-de-obra e área de plantio. Foi realizada uma análise da demanda de laranja de mesa no Estado de São Paulo, determinando-se a equação de regressão descrevendo seu comportamento, a partir desta análise foi construída uma distribuição de probabilidade de demanda de laranja de mesa para o Estado de São Paulo e para o empreendimento, objeto de estudo. A partir destes resultados foi gerada a curva de retorno esperado do empreendimento para a construção de cenários de retorno do investimento. Este trabalho demonstrou a facilidade de aplicação das ferramentas utilizadas em empreendimentos de pequeno porte, fornecendo subsídios para decisões do investidor
Abstract: This investigation describes a set of models to support the decision of a citrus variety selection for an agricultural enterprise located at Porto Ferreira/SP. To achieve this goal were applied the Linear Programming and Expected Return Analysis techniques. By the use of three linear programming models, one of them developed on Integer Programming, were considered seven citrus varieties as decision variables and three constraints: total investment in agro-chemicals, labor and area; the models provided suggestions of land occupation. By the analysis of historical information regarding Citrus production in São Paulo Estate, was developed a Expected Return Analysis for the Citrus production in São Paulo Estate and for the enterprise as well, focused on return on investment. The results obtained from this investigation are important to describe a methodology for supporting the investor decision making process in small agricultural business, due to the easy application of the techniques
Mestrado
Planejamento e Gestão Estrategica da Manufatura
Mestre Profissional em Engenharia Mecanica
Fallon, John E. "Naval Fuel Management System (NFMS) a decision support system for a limited resource." Thesis, Monterey, California. Naval Postgraduate School, 2010. http://hdl.handle.net/10945/5166.
Повний текст джерелаIncludes supplemental material, embedded in this pdf. See page 46 of document to read instructions for accessing supplemental material.
The fuel planning for U.S. Naval operations at sea is reactive and relies upon pen and paper calculations. Decisions on where and when to refuel are complex and need a Decision Support System (DSS) to help planners maximize the benefits of the limited fuel resource. This thesis defines requirements and outlines a feasible design to develop a Naval Fuel Management System (NFMS). The variables that fuel planning rely upon are not just ship course and speed, but also the weather at the time a ship travels through a particular area. The most efficient plant configuration plays a factor in the fuel plan as well. Additionally, there are numerous ports and oilers available at any given time. Up-to-date accurate weather forecast databases are available, predicting currents and winds, which will affect the ship in the future. Fuel burn charts have been developed for each ship class outlining the most efficient plant configuration for given speeds. Transportation analysis has shown that an optimal path exists for this class of complex problems. By combining these technologies into one system, an application can be developed to accurately plan fueling operations in the future, making Navy refueling more efficient.
US Navy (USN) author
Bergert, Franklin Bryan. "Using response time to distinguish between lexicographic and linear models of decision making." [Bloomington, Ind.] : Indiana University, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3297942.
Повний текст джерелаTitle from dissertation home page (viewed Sept. 30, 2008). Source: Dissertation Abstracts International, Volume: 69-03, Section: B, page: 1980. Adviser: Robert M. Nosofsky.
Collison, Sean Michael. "Extending the Dorsch decoder for efficient soft decision decoding of linear block codes." Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Thesis/Spring2009/s_collison_042309.pdf.
Повний текст джерелаTitle from PDF title page (viewed on May 21, 2009). "School of Electrical Engineering and Computer Science." Includes bibliographical references (p. 64-65).
Angel, N. Faye. "Collaborative Study and Paired Test Taking in Collegiate Level Linear Programming Instruction." Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/30746.
Повний текст джерелаPh. D.
MELO, Milton Perceus Santos de. "Programação linear e simulação multidimensional no mercado financeiro e commodities." Universidade Federal Rural de Pernambuco, 2012. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5222.
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Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
Usually after planting, the agricultural property attempts to assess the operational performance of the previous years through studies in order to face posteriorly a new period of activities with the beginning of a new crop. The results led the landowners to create expectations about the expansion or reduction of crops, staff hiring, supply purchasing and new investments. All these questions are relevant deriving from climatic variations, pest manifestations and from fluctuations in the economy which directly influence in the the prices of the agricultural products. However the producers face the need of making decisions which often completely change the operating process of production. In large scale these decisions influence directly the supply and the price of the products. Having in consideration that the techniques used in agricultural planning are of great value for the producers, a decision aid methodology which considers the risks in the process is applied on the spot market of agricultural commodities in order to provide the best combination of variables aiming the profit optimization. Therefore, in this it was jointly used simulation technique and linear programming taking into account the existent correlations between the coefficients of the model. The data were obtained from historic trends regarding the monthly average price of 44 agricultural commodities commercialized in the European spot market since January 1960 till September 2011. Regarding the computational part, it was used the software SAS, version 5.2. By applying the proposed method the results show that the use of simulation without dependence did not underestimate the risk when compared to the simulation with dependence and they also show that the technique did not allow the perception of the best moment to make the investment, yet fully satisfactory as a decision support tool.
Comumente após o plantio, a propriedade agrícola tenta avaliar o desempenho operacional dos anos anteriores através de estudos para posteriormente enfrentar um novo período de atividades com o início de uma nova safra. Os resultados levam os proprietários agrícolas a criar expectativas em torno de expansão ou redução de culturas, contratação de pessoal, compra de insumos e a novos investimentos. Todas estas indagações são pertinentes, provenientes de variações climáticas, manifestações de pragas e oscilações na economia que influenciam diretamente no preço dos produtos agrícolas. Contudo, os produtores deparam-se com a necessidade de tomar decisões que, muitas vezes, alteram completamente o processo operacional da produção. Em larga escala, estas decisões influenciam diretamente na oferta e no preço dos produtos. Entendendo que as técnicas utilizadas no planejamento agrícola são de grande valia para os produtores, uma metodologia de auxílio à decisão que consideram os riscos presentes no processo é aplicada no mercado à vista de commodities agrícolas com o objetivo de fornecer a melhor combinação de variáveis visando à otimização do lucro. Portanto, nesta dissertação foi utilizada uma técnica de simulação e programação linear, conjuntamente, levando em consideração as correlações existentes entre os coeficientes do modelo. Os dados foram obtidos de séries históricas referentes ao preço médio mensal de 44 commodities agrícolas comercializadas no mercado europeu à vista no período de janeiro de 1960 a setembro de 2011. Quanto à parte computacional, foi utilizado o software SAS, versão 9.2. Com a aplicação do método proposto, os resultados encontrados mostram que o uso da simulação sem dependência não subestimou o risco quando comparado à simulação com dependência e que a técnica não possibilitou a percepção do melhor momento para realizar o investimento, no entanto plenamente satisfatória como ferramenta de suporte à decisão.
Curtis, S. McKay. "The "fair" triathlon : equating standard deviations using non-linear Bayesian models /." Diss., CLICK HERE for online access, 2004. http://contentdm.lib.byu.edu/ETD/image/etd428.pdf.
Повний текст джерелаChan-Taw, Stephan. "Performance of linear detectors using partial decision techniques in CDMA systems with multiple antenna." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27615.
Повний текст джерела鄧沛權 and Pui-kuen Tang. "Bayesian analysis of errors-in-variables in generalized linear models." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1992. http://hub.hku.hk/bib/B31232802.
Повний текст джерелаTang, Pui-kuen. "Bayesian analysis of errors-in-variables in generalized linear models /." [Hong Kong : University of Hong Kong], 1992. http://sunzi.lib.hku.hk/hkuto/record.jsp?B1325330X.
Повний текст джерелаLoPinto, Frank Anthony. "An Agent-Based Distributed Decision Support System Framework for Mediated Negotiation." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/27401.
Повний текст джерелаPh. D.
Botero, Alonso. "Sampling weak values : a non-linear Bayesian model for non-ideal quantum measurements /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.
Повний текст джерелаLiu, Yu. "Estimation, Decision and Applications to Target Tracking." ScholarWorks@UNO, 2013. http://scholarworks.uno.edu/td/1758.
Повний текст джерелаSantos, Ana Paula dos. "Resolução do modelo de Li e Reeves usando programação por metas." Niterói, 2017. https://app.uff.br/riuff/handle/1/4084.
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A baixa discriminação e o esquema de multiplicadores pouco realistas são frequentemente apontadas como limitações da Análise Envoltória de Dados (DEA, de Data Envelopment Analysis). Com o propósito de amenizá-las, o modelo MCDEA (Multiple Criteria DEA) foi desenvolvido sob uma perspectiva multiobjetivo. Como na maioria dos problemas multiobjetivo, o modelo MCDEA não costuma gerar uma solução ótima única, mas um conjunto de soluções não dominadas. Buscando obter uma solução, que, tanto quanto possível, otimize conjuntamente as funções objetivo do modelo MCDEA, foram propostas abordagens baseadas na metodologia de programação por metas (GP, de Goal Programming). Dentre elas, destacam-se os modelos GPDEA, que usam programação por metas do tipo soma ponderada. Contudo, recentemente, os modelos GPDEA foram considerados inválidos, sem que nenhuma formulação alternativa baseada em programação por metas fosse proposta. Visando preencher tal lacuna, esta tese tem o objetivo de desenvolver formulações que solucionem, apropriadamente, o modelo MCDEA, para o caso de retornos constantes e variáveis de escala, mediante o uso de programação por metas do tipo soma ponderada. Essas formulações foram denominadas modelos WGP-MCDEA (Weighted GP-MCDEA), e englobam tanto a orientação a inputs como a outputs. Os modelos propostos geram as soluções básicas não dominadas dos modelos MCDEA correspondentes, quando os níveis de aspiração para as metas são precisamente definidos com este fim. Quando esses níveis são relaxados, em geral, os modelos WGP-MCDEA geram as soluções não dominadas dos modelos MCDEA correspondentes que cobrem a maior área na região de indiferença dos pesos.
Low discrimination and unrealistic multipliers schemes are often cited as limitations of DEA. To mitigate those limitations, the MCDEA model was developed under a multi-objective perspective. As in most multiple objective problems, MCDEA model does not usually result in a unique optimal solution, but in a set of non-dominated solutions. In an attempt to obtain a satisfactory solution, which, as far as possible, jointly optimizes MCDEA´s objective functions, some goal-programming-based approaches were proposed. Among those proposals, we highlight the GPDEA models, which use weighted goal programming. However, recently, GPDEA models were considered invalid, without any alternative goal-programming-based formulation being proposed. Seeking to fill this gap, the objective of this dissertation is to develop formulations that appropriately solve MCDEA model for the cases of constant and variable returns-to-scale, by means of weighted goal programming. These formulations were called WGP-MCDEA models, and include both input and output orientations. The proposed models generate the basic non-dominated solutions of the corresponding MCDEA models when the goals´ aspiration levels are specifically defined for this purpose. When those aspiration levels are smoothened, the WP-MCDEA models generally produce the non-dominated solution of the corresponding MCDEA models that cover the largest area in the indifference region.
Oliveira, Hugo Rocha de. "Análise do aproveitamento múltiplo do reservatório de Barra Bonita - SP, através da aplicação de técnica de programação linear associada a modelo de rede de fluxo." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/18/18138/tde-09062016-093336/.
Повний текст джерелаThe aim of this study is to analyze the multiple use of the Barra Bonita reservoir, which is located in the confluence of the Piracicaba river and the Tietê river, in the state of São Paulo, and belongs to the called Tietê-Paraná system. The reservoir operation will be optimized, through linear programming, aiming to increase the hydropower generation, by maximizing the water flow through turbines. In sequence, on the hydropower generation optimization results, computer simulation techniques will be used, in order to obtain performance rates as reliability, resilience and vulnerability, in addiction to other rates provided by the simulation model itself. These rates can assist to evaluate the frequency, the magnitude and the duration of possible conflicts that may occur. The navigation, the water storage in the reservoir, the hydropower generation and the occurrence of floods in Barra Bonita, a city located downstream the dam, will be analyzed.
Mehmood, Rashid. "Fuzzy linear programming problems solved with Fuzzy decisive set method." Thesis, Blekinge Tekniska Högskola, Sektionen för ingenjörsvetenskap, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-1201.
Повний текст джерелаDinger, Steven. "Essays on Reinforcement Learning with Decision Trees and Accelerated Boosting of Partially Linear Additive Models." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1562923541849035.
Повний текст джерелаRisberg, Daniel. "Robust Optimization in Seasonal Planning of Hydro Power Plants." Thesis, KTH, Optimeringslära och systemteori, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-173478.
Повний текст джерелаCharchan, Shawn M. "Promoting mission success for the USMC Distributed Operations squad through efficient equipment selection." Thesis, Monterey, California. Naval Postgraduate School, 2006. http://hdl.handle.net/10945/2552.
Повний текст джерелаFox, David. "Dynamic demand modelling and pricing decision support systems for petroleum." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/dynamic-demand-modelling-and-pricing-decision-support-systems-for-petroleum(2ce6efed-a7eb-4d10-b325-4d4590ba57ad).html.
Повний текст джерелаZhou, Yifan. "Asset life prediction and maintenance decision-making using a non-linear non-Gaussian state space model." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/41696/1/Yifan_Zhou_Thesis.pdf.
Повний текст джерелаPanchenko, Evgeny. "Sustainable Planning of Linear Infrastructure Corridor in Remote Areas." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1542777301682337.
Повний текст джерелаCaetani, Alberto Pavlick. "Uso de método multicritério para seleção de estratégia de reconversão industrial em uma refinaria de petróleo." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/101513.
Повний текст джерелаThis dissertation presents a selection process of industrial reconversion strategy in a small oil refinery in southern Brazil by applying an integrated modeling approach, using a multicriteria and a mathematical programming method. Potentially performing business lines were identified, as well a set of criteria covering the three dimensions of corporate sustainability: economic, social and environmental. Based on the relative importance evaluation of each criteria given by a group of decision-makers, and on performance of the business lines in each of the criteria, fuzzy TOPSIS method was applied for analysis and sorting of business lines. The information resulting from this analysis, along with objective economic data, were used in integer linear programming model to evaluate effective portfolios of business lines, identifying candidate strategies to implement in the refinery. Fuzzy TOPSIS is used to generate overall performance scores of each candidate strategy, aggregating the individual performance of the business lines. The sustainability assessment was analyzed through graphical tools in order to generate information to support the selection of the best strategy for the industrial reconversion. The results demonstrated the efficiency of the proposed approach to facilitate the understanding and exploitation of the problem situation and thus offer adequate support to decision making.
Spak, Marcia Danieli Szeremeta. "Proposta de uma metodologia de apoio à tomada de decisão para a localização de centros de distribuição no setor varejista de móveis e eletrodomésticos." Universidade Tecnológica Federal do Paraná, 2012. http://repositorio.utfpr.edu.br/jspui/handle/1/604.
Повний текст джерелаThe retail sector of furniture and appliances is in expansion and is directly affected by market competitiveness. The Companies in this sector are constantly seeking reduction of prices and delivery times of products, to maintain their position before competitors. One of the factors that directly influence the competitiveness of these organizations are the high costs of the distribution system. In order to reduce the impacts on the distribution system, the present study aimed to propose a model to support decision making for the location of distribution centers in the retail sector of furniture and appliances. The work divided into three stages for its conception. In the first stage was used a non-linear programming model to define an optimal point in the region covered in the study and subsequently been identified five cities around that optimal point. The second stage was composed by defining criteria and sub-criteria that influence the decision, and the application of AHP method for selecting the best city for installing the distribution center. In the third stage is sought to identify the best ground among three alternatives, that been evaluated by AHP method from the definition of criteria and sub-criteria directed this decision context. The result show that the factor transport and market are mainly responsible for choosing the city, and the installation and accessibility to the location of the ground. The study identified the alternative Arapongas as the best city and the ground 3 as the best place to install the distribution center.