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Статті в журналах з теми "Leishmania- Disease"
Kostygov, Alexei Y., Danyil Grybchuk, Yulia Kleschenko, Daniil S. Chistyakov, Alexander N. Lukashev, Evgeny S. Gerasimov, and Vyacheslav Yurchenko. "Analyses of Leishmania-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins." Viruses 13, no. 11 (November 19, 2021): 2305. http://dx.doi.org/10.3390/v13112305.
Повний текст джерелаSoni, Mohini, and J. Venkatesh Pratap. "Development of Novel Anti-Leishmanials: The Case for Structure-Based Approaches." Pathogens 11, no. 8 (August 22, 2022): 950. http://dx.doi.org/10.3390/pathogens11080950.
Повний текст джерелаJain, Surbhi, Utkarsha Sahu, Awanish Kumar, and Prashant Khare. "Metabolic Pathways of Leishmania Parasite: Source of Pertinent Drug Targets and Potent Drug Candidates." Pharmaceutics 14, no. 8 (July 30, 2022): 1590. http://dx.doi.org/10.3390/pharmaceutics14081590.
Повний текст джерелаCarstens-Kass, Jessica, Kayla Paulini, Patrick Lypaczewski, and Greg Matlashewski. "A review of the leishmanin skin test: A neglected test for a neglected disease." PLOS Neglected Tropical Diseases 15, no. 7 (July 22, 2021): e0009531. http://dx.doi.org/10.1371/journal.pntd.0009531.
Повний текст джерелаKurkjian, K. M., L. E. Vaz, R. Haque, C. Cetre-Sossah, S. Akhter, S. Roy, F. Steurer, et al. "Application of an Improved Method for the Recombinant K39 Enzyme-Linked Immunosorbent Assay To Detect Visceral Leishmaniasis Disease and Infection in Bangladesh." Clinical Diagnostic Laboratory Immunology 12, no. 12 (December 2005): 1410–15. http://dx.doi.org/10.1128/cdli.12.12.1410-1415.2005.
Повний текст джерелаKhademvatan, Shahram, Kaveh Eskandari, Batool Sadeghi Nejad, and Sedigheh Yusef Naanaie. "Cytotoxic Effects of Artemisia Dracunculus L. and Heracleum Persicum Desf. Extracts on Leishmania major and Leishmania infantum Promastigotes Using MTT Assay." International Journal of Enteric Pathogens 9, no. 2 (May 29, 2021): 59–63. http://dx.doi.org/10.34172/ijep.2021.12.
Повний текст джерелаMaciej-Hulme, Marissa L., Mark A. Skidmore, and Helen P. Price. "The role of heparan sulfate in host macrophage infection by Leishmania species." Biochemical Society Transactions 46, no. 4 (June 22, 2018): 789–96. http://dx.doi.org/10.1042/bst20170398.
Повний текст джерелаMcDowell, Mary Ann, Mary Marovich, Rosalia Lira, Michael Braun, and David Sacks. "Leishmania Priming of Human Dendritic Cells for CD40 Ligand-Induced Interleukin-12p70 Secretion Is Strain and Species Dependent." Infection and Immunity 70, no. 8 (August 2002): 3994–4001. http://dx.doi.org/10.1128/iai.70.8.3994-4001.2002.
Повний текст джерелаGogou, Georgia, Olga S. Koutsoni, Panagiotis Stathopoulos, Leandros A. Skaltsounis, Maria Halabalaki, and Eleni Dotsika. "Direct In Vitro Comparison of the Anti-Leishmanial Activity of Different Olive Oil Total Polyphenolic Fractions and Assessment of Their Combined Effects with Miltefosine." Molecules 27, no. 19 (September 21, 2022): 6176. http://dx.doi.org/10.3390/molecules27196176.
Повний текст джерелаJalaj Kumar Gour and Manoj Kumar Singh. "Leishmanial Excretory-Secretory proteins: A potent vaccine candidate." International Journal of Fundamental and Applied Sciences (IJFAS) 7, no. 1 (March 30, 2018): 18–22. http://dx.doi.org/10.59415/ijfas.v7i1.118.
Повний текст джерелаДисертації з теми "Leishmania- Disease"
Scorza, Breanna M. "Interaction of human keratinocytes with Leishmania spp.: a comparative study of Leishmania infantum and Leishmania major." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5847.
Повний текст джерелаAdamson, Rachel Elizabeth. "Molecular studies of Venezuelan sandflies and Leishmania isolates." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385097.
Повний текст джерелаLara, Diana. "Cationic steroid antibiotics as potential chemotherapeutic agent against Trypanosoma cruzi and Leishmania major." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2007. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.
Повний текст джерелаThalhofer, Colin Joseph. "Leishmania infantum chagasi induces a dynamic cellular inflammatory response." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1091.
Повний текст джерелаSolano, Gallego Laia. "Leishmania infantum and dog: immunological and epidemiological studies about infection and disease." Doctoral thesis, Universitat Autònoma de Barcelona, 2001. http://hdl.handle.net/10803/5719.
Повний текст джерелаEl capítol 2 descriu l'expressió d'anticossos anti-Leishmania IgG, IgG1 i IgG2 en una població de gossos. Els nivells d'immunoglobulines en gossos asimptomàtics van ser molt variables i menors que els dels animals malalts. En els animals malalts, els nivells de IgG i IgG2 van ser molt alts però els nivells d' IgG1 molt variables. Els resultats van mostrar la gran variació en l'expressió de IgG1 tant en gossos asimptomàtics com en simptomàtics, així com la baixa correlació de la IgG1 amb la IgG o IgG2.
El capítol 3 descriu l'avaluació i comparació de l'eficàcia de dues preparacions de leishmanines en la detecció de la resposta cel·lular davant de Leishmania en el gos.
El capítol 4 mostra l'estudi de la resposta humoral i cel·lular en una població de gossos. El 77% dels gossos va mostrar una resposta immunitària específica davant de Leishmania, ja fos humoral o cel·lular. El 80% dels cans eivissencs i el 48% dels gossos d'altres races van presentar resposta cel·lular. Els resultats van mostrar que la taxa d'infecció era molt alta, i que els gossos presentaven un ampli ventall de respostes inmunitàries, des de gossos resistents fins a gossos malalts. El ca eivissenc va manifestar més uniformement resposta cel·lular.
El capítol 5 descriu l'estudi de la prevalença de la malaltia, la seroprevalença i la prevalença de la infecció. Es va analitzar el quadre clínic, la serologia i la presència d'ADN de Leishmania en diferents teixits. La prevalença de la malaltia i seroprevalença van ser, respectivament, d'un 13% i d'un 26%. Els resultats de PCR positives en moll d'ós, conjuntiva i pell van ser respectivament, d'un 18%, 32% i 51%. La prevalença de la infecció va ser d'un 67%. La majoria de gossos de zona endèmica ha estat infectat pel paràsit.
El capítol 6 descriu l'estudi de paràmetres immunològics (serologia, test intradèrmic amb leishmanina, assaig de proliferació de limfòcits i detecció d'IFN-g i TNF-a) en l'avaluació de gossos infectats amb Leishmania. La majoria dels animals infectats sense simptomatologia clínica presentava nivells variables d'anticossos, reacció positiva al test intradèrmic, bona resposta proliferativa al antigen de Leishmania i producció d'IFN-g. La resta va mostrar nivells variables d'anticossos però absència de reacció al test intradèrmic. Abans del tractament, els animals malalts presentaven alts nivells d'anticossos, test intradèrmic negatiu, no producció d'IFN-g i producció de TNF-a. La millora clínica es va associar amb la disminució dels anticossos i amb l'augment del diàmetre del test intradèrmic. La combinació de la serologia, el test intradèrmic i la medició de citocines constitueixen tècniques útils i d'alta rellevància clínica en l'avaluació de la resposta inmunitària d'un pacient individual.
The objective of this thesis was to obtain new knowledge about the immunology and epidemiology of Leishmania infection in dogs living in endemic regions in the Mediterranean basin.
Chapter 2 describes the expression of IgG, IgG1 and IgG2 specific antibodies to L. infantum in a wide population of dogs. The levels of immunoglobulins in asymptomatic dogs were highly variable and lower than those found in ill dogs. In ill dogs, the levels of IgG and IgG2 were very high but the levels of IgG1 were extremely variable. Overall results showed a large variation in the IgG1 expression in asymptomatic and symptomatic dogs and a low IgG1 correlation with IgG or IgG2.
Chapter 3 describes the evaluation and comparison of the efficacy of two leishmanins for detection dog Leishmania cellular immune response.
Chapter 4 describes the study of humoral and cellular responses in a population of dogs. Seventy-seven percent of the dogs demonstrated a specific Leishmania response either humoral or cellular. Eighty percent of ibizian hounds and 48% of dogs of other breeds presented a cellular response. The results showed that the rate of infection was high and that dogs presented a broad range of immune responses from resistant to ill dogs. The Ibizian hound manifested a more uniform cellular response.
Chapter 5 describes the study of the prevalence of Leishmania infection, the seroprevalence and the prevalence of canine leishmaniosis. Clinical exploration for the presence of clinical signs compatible with leishmaniosis, the titre of anti-Leishmania antibodies, and the presence of Leishmania DNA by PCR on several tissues were assessed. The prevalence of the disease was 13% and the seroprevalence was 26%. The results of positive PCR in the bone marrow, the conjunctiva and the skin were 18%, 32% and 51%, respectively. The prevalence of the infection was 67%. The results showed that Leishmania infects the majority of dogs living in an endemic area.
Chapter 6 describes the study of immunological parameters (anti-Leishmania IgG1, IgG2, total IgG antibodies, LST, LPA, and production of IFN-g and TNF-a) in the evaluation of dogs infected by Leishmania. The majority of infected animals without clinically patent disease showed variable titres of anti-Leishmania antibodies, a positive LST, a strong Leishmania antigenic proliferative response, and a high production of IFN-g. The remainder showed positive titres of anti-Leishmania antibodies with a negative positive LST. Before treatment, ill dogs presented high levels of anti-Leishmania antibodies, negative LST, no production of IFN-g but a production of TNF-a. Clinical recovery was associated with a decrease in the titre of antibodies and an increase of the diameter of the LST. The combination of serology, LST, and measurement of cytokines constitutes a useful, clinically relevant method to evaluate the immune response to Leishmania in a single patient.
Depledge, Daniel Pearce. "Comparative genomic analysis of three Leishmania species that cause diverse disease pathologies." Thesis, University of York, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495870.
Повний текст джерелаTezuka, Daiane Yukie. "Triagem de compostos anti-chagásicos com o Trypanosoma cruzi e leishmanicidas com as espécies Leishmania amazonensis e Leishmania chagasi." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-25112015-101003/.
Повний текст джерелаInfections caused by trypanosomatides lead to thousands of deaths annually, besides the reduction of the quality of life and working capability, with high morbidity to the patients. The therapy efficacy is limited in most cases, being benznidazole the only approved drug in Brazil, which works only in the acute phase of the Chagas Disease with severe collateral effects. For leishmaniasis, the drugs cause renal and cardiac toxicity and trigger resistance. In this context, novel efficacious and secure substantes are necessary to improve the current therapeutic strategies, which was the goal of this project by means of cell-based assays. The first step was the standardization of the MTT colorimetric assay for the epimastigote form of the Y strain of Trypanosoma cruzi and promastigote form of Leishmania chagasi and Leishmania amazonensis. This was achieved by comparing the results with the standard counting using the Neubauer chamber. The use flow cytometry for the determination of cell viability and the perturbation of the cell cycle were also standardized using the reference drugs benznidazole (T. cruzi) and amphotericin B (Leishmania spp.). New compounds tested in this project were designed or selected based on different macromolecular targets (cysteine proteases, DHODH, GAPDH, kinases) by the Medicinal Chemistry Group (NEQUIMED). Among them, many kinase inhibitors promoted the most dramatic results for T. cruzi, reducing the cell viability of this parasite. One of them (Neq0474) was subjected for a follow-up dose-response assay, with EC50 = 53 µmol/L. L. chagasi was the most resistant parasite in this work, whereas L. amazonensis was sensitive to Neq0438. Some of these new compounds are of interest for more in-depth studies to these parasitic diseases.
Alessi, Claudia Alvares Calvo. "Leishmaniose cutânea americana no Pontal do Paranapanema - SP: avaliação clínica, histopatológica e uso da reação em cadeia da polimerase (PCR) para identificação e caracterização das espécies de Leishmania." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-17022009-115336/.
Повний текст джерелаLeishmaniasis are parasitic diseases caused by protozoans of the Leishmania genus and are important public health problems. American cutaneous leishmaniasis (ACL) is considered an autochthonous disease of the American continent and presents several clinical forms which depend on the causative species of the infection and other factors such as virulence and ability to evade the immune system. Six Leishmania species are recognized to cause human ACL cases in Brazil of which five belong to the Viannia and one to the Leishmania subspecies. They are: Leishmania (Viannia) braziliensis, Leishmania (Viannia) guyanensis, Leishmania (Viannia) lainsoni, Leishmania (Viannia) shawi, Leishmania (Viannia) naiffi and Leishmania (Leishmania) amazonensis. Cutaneous leishmaniasis transmission is maintained in the Pontal do Paranapanema region, with 20 notified cases in 2006. Leishmania (V.) braziliensis is the only species considered to be the disease agent in the region with identification of the involved vectors and possible wild reservoirs. The aim of this research is the studies of the epidemiological, clinical and histopathological aspects of cutaneous leishmaniasis in the Pontal do Paranapanema and the identification by molecular methods, PCR, of the etiologic agent and characterization of the Leishmania genus, subgenus and species present in the region. The disease was found in both genders, with predominance of males (67.9%), in all age ranges, but 70.5% were in the range of 20 to 49 years. The cutaneous was the mostly found clinical form with 92.3% of the cases. Search for the parasite in the lesion of 78 patients who underwent biopsies was positive in 40 samples (51.5%), in HE stained slides; when IH was used, 66.7% were positive. Agreement index between the HE and IH techniques were 58.97%. However, 10 negative cases using IH were positive with HE, and of 38 HE negative cases 22 were positive using IH. This shows that association of the two methods is needed. Using PCR, there was a positivity of 53.8%. Evaluating the results obtained in this study, we may observe that of the 40 HE positive cases 24 were also positive on PCR; but 16 of these were PCR negative. Contrariwise, of the 38 HE negative samples 18 were positive PCR. Using immunohistochemistry, of the total of 38 HE negative samples, 18 were positive with PCR; while of the 52 IH positive samples, 28 were positive and 24 negative on PCR. Agreement levels of PCR with HE were 56.41%, and of PCR with IH 51.28%. These results reinforce the idea of the need for association of the three methods for CL diagnosis. Histopathological lesion characteristics were: granulomatous reaction (GR) found in 71.85%, granulomatous reaction with giant cells (GRGC) in 12.8T, granulomatous reaction with necrosis (GRN) in 10.3% and granuloma with necrosis and giant cells (GRNGC) in 5.1% of the cases. Using SSU rDNAS 17/S18 primers it was possible to characterize through sequencing 27 (34.6%) samples as being of the Viannia subgenus and 06 samples of the L. (L.).amazonensis This study identified the first L. (L.) amazonensis case in the region
Karam, Marc Christophe. "The role of cytokines in the regulation of hyperalgesia and disease progression in Leishmania major infection." Thesis, University of Surrey, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431123.
Повний текст джерелаPereira, Lucas Campana. "Busca de genes associados à resposta ao teste de Montenegro para antígenos de Leishmania." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-27022013-155152/.
Повний текст джерелаThe present study aims, through genetic-epidemiological methods, to identify genes associated with response to Leishmania antigen. Using samples Montenegro skin test through the municipalities of Monte Negro (RO) and Assis Brazil (AC). In the first approach were tested with TaqManÒ and the second GWAS, and association analyzes were performed using SPSS and Plink. No associations were found with five SNPs (MyD88, IL12, IL10, IFNGR1, and NRAMP1). The analysis of genome scan data with filters, indicated a region on chromosome 10 with three nearby SNPs that are part of a regulatory region that later with the help of real time is not confirmed, although the test rs11251056 have borderline values, becoming an possible direction for future work and finally the last test was the meta-analysis by the method of Woolf, presented results indicating the association found in tests for chromosome 2 with ZNF638 related to cell differentiation and also on chromosome 10 that contains lincRNAs and gene NGR3, two runs with a significant p value, where we can infer that these two regions can actively participate in the differentiation of the response to Leishmania antigen.
Книги з теми "Leishmania- Disease"
J, Farrell, ed. Leishmania. Boston, Mass: Kluwer Academic Pub., 2002.
Знайти повний текст джерелаFarrell, Jay P. Leishmania. Springer London, Limited, 2012.
Знайти повний текст джерелаLydyard, Peter, Michael Cole, John Holton, Will Irving, Nino Porakishvili, Pradhib Venkatesan, and Kate Ward. Case Studies in Infectious Disease: Leishmania spp. Garland Science, 2009. http://dx.doi.org/10.4324/9780203853917.
Повний текст джерелаGuideline for the Treatment of Leishmaniasis in the Americas. Second Edition. Pan American Health Organization, 2022. http://dx.doi.org/10.37774/9789275125038.
Повний текст джерелаGramiccia, Marina. The Leishmanioses. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0051.
Повний текст джерелаInteractive Atlas of Leishmaniasis in the Americas: Clinical Aspects and Differential Diagnosis. Organización Panamericana de la Salud, 2020. http://dx.doi.org/10.37774/9789275121900.
Повний текст джерелаKaufman, S. T-cell Paradigms In Parasitic And Bacterial Infections (Current Topics in Microbiology & Immunology). Edited by S. Kaufman. Springer, 1990.
Знайти повний текст джерела(Editor), José-Luis Avila, and J. Robin Harris (Editor), eds. Intracellular Parasites (Subcellular Biochemistry). Springer, 1992.
Знайти повний текст джерелаЧастини книг з теми "Leishmania- Disease"
Lydyard, Peter M., Michael F. Cole, John Holton, William L. Irving, Nina Porakishvili, Pradhib Venkatesan, and Katherine N. Ward. "Leishmania spp." In Case Studies in Infectious Disease, 193–99. 2nd ed. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003155447-20.
Повний текст джерелаBates, Paul A. "Infection of phlebotomine sandflies with Leishmania." In The Molecular Biology of Insect Disease Vectors, 112–20. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-009-1535-0_10.
Повний текст джерелаZhang, Wen-Wei, and Greg Matlashewski. "Screening Leishmania donovani Complex-Specific Genes Required for Visceral Disease." In Methods in Molecular Biology, 339–61. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1438-8_20.
Повний текст джерелаDedet, Jean-Pierre. "Trypanosomatidae: Leishmania Species, Trypanosoma cruzi (Chagas Disease), and Associated Complications." In Sequelae and Long-Term Consequences of Infectious Diseases, 275–89. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555815486.ch16.
Повний текст джерелаDas, Partha, MD Nur Alam, Tripti De, and Tapati Chakraborti. "Proteases as Virulence Factors in Leishmania: Focus on Serine Proteases as Possible Therapeutic Targets." In Proteases in Health and Disease, 135–61. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-9233-7_9.
Повний текст джерелаCoelho, Eduardo A. F., and Myron Christodoulides. "Vaccines for Canine Leishmaniasis." In Vaccines for Neglected Pathogens: Strategies, Achievements and Challenges, 281–306. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-24355-4_13.
Повний текст джерелаMock, B. A., A. H. Fortier, M. Potter, J. Blackwell, and C. A. Nacy. "Genetic Control of Systemic Leishmania major Infection: Identification of Subline Differences for Susceptibility to Disease." In Current Topics in Microbiology and Immunology, 115–21. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70740-7_17.
Повний текст джерелаDespommier, Dickson D., Robert W. Gwadz, and Peter J. Hotez. "Leishmania tropica (Wright 1903) and Leishmania mexicana (Biagi 1953)." In Parasitic Diseases, 203–9. New York, NY: Springer New York, 1995. http://dx.doi.org/10.1007/978-1-4612-2476-1_32.
Повний текст джерелаMaurício, Isabel L. "Leishmania Taxonomy." In The Leishmaniases: Old Neglected Tropical Diseases, 15–30. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-72386-0_2.
Повний текст джерелаDespommier, Dickson D., Robert W. Gwadz, and Peter J. Hotez. "Leishmania braziliensis (Vianna 1911)." In Parasitic Diseases, 209–13. New York, NY: Springer New York, 1995. http://dx.doi.org/10.1007/978-1-4612-2476-1_33.
Повний текст джерелаТези доповідей конференцій з теми "Leishmania- Disease"
Movsesyan, S. O., R. A. Petrosyan, M. A. Nikogosyan, R. E. Barsegyan, N. B. Terenina, M. V. Voronin, and M. V. Vardanyan. "BIODIVERSITY OF THE PARASITE FAUNA IN THE NORTHERN REGIONS OF ARMENIA AND THE LAKE SEVAN BASIN." In THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL. All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”, 2023. http://dx.doi.org/10.31016/978-5-6048555-6-0.2023.24.306-311.
Повний текст джерелаSILVA, SERGIO E. LEMOS DA, BRUNA SCARPELLI PEDROSA VIEIRA, BRUNO RODRIGO DE MEDEIROS, EMILLENE MARIA SILVA OLIVEIRA, JULIANA DA CONCEIçãO SILVA FIGUEIREDO, and MARIA DAGUIJARA SANTOS SILVA. "HEALTH INDICATORS OF CANINE VISCERAL LEISHMANIASIS AS TOOLS FOR CONTROL AND PREVENTION IN BRAZIL." In II South Florida Congress of Development. brazco, 2022. http://dx.doi.org/10.47172/iisfcdv2022.0022.
Повний текст джерела