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Добірка наукової літератури з теми "Lectin receptor"

Автор: Grafiati

Опубліковано: 16 листопада 2024

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Статті в журналах з теми "Lectin receptor"

Masnikosa, Romana, Anna Nikolic, and Olgica Nedic. "Lectin-induced alterations of the interaction of insulin and insulin-like growth factor 1 receptors with their ligands." Journal of the Serbian Chemical Society 73, no. 8-9 (2008): 793–804. http://dx.doi.org/10.2298/jsc0809793m.

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In order to study whether the carbohydrate moieties of the human placental IGF-I receptor (IGF1R), IGF-II receptor (IGF2R) and insulin receptors (IRs) play a role in ligand binding, solubilised cell membrane preparations were incubated with 125I-labelled IGF-I, IGF-II and insulin in the presence of lectins with different sugar specificities. Three incubation procedures were tested: ligand-first, co-incubation and lectin-first incubation. Wheat germ agglutinin (WGA), concanavalin A (Con A) and phytohaemagglutinin (PHA) altered the binding of IGF-I and insulin to their high-affinity receptors in a lectin specific and dose-dependent manner, whereas these lectins did not affect the interaction of IGF-II with its receptor(s). Moreover, the same lectins either inhibited or enhanced IGF-I and insulin binding, depending on the incubation scheme. These results also suggest that IR-A and IR-B from human placenta might be differently glycosylated.

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Jégouzo, Sabine A. F., Conor Nelson, Thomas Hardwick, S. T. Angel Wong, Noel Kuan Kiat Lau, Gaik Kin Emily Neoh, Rocío Castellanos-Rueda, et al. "Mammalian lectin arrays for screening host–microbe interactions." Journal of Biological Chemistry 295, no. 14 (February 24, 2020): 4541–55. http://dx.doi.org/10.1074/jbc.ra120.012783.

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Many members of the C-type lectin family of glycan-binding receptors have been ascribed roles in the recognition of microorganisms and serve as key receptors in the innate immune response to pathogens. Other mammalian receptors have become targets through which pathogens enter target cells. These receptor roles have often been documented with binding studies involving individual pairs of receptors and microorganisms. To provide a systematic overview of interactions between microbes and the large complement of C-type lectins, here we developed a lectin array and suitable protocols for labeling of microbes that could be used to probe this array. The array contains C-type lectins from cow, chosen as a model organism of agricultural interest for which the relevant pathogen–receptor interactions have not been previously investigated in detail. Screening with yeast cells and various strains of both Gram-positive and -negative bacteria revealed distinct binding patterns, which in some cases could be explained by binding to lipopolysaccharides or capsular polysaccharides, but in other cases they suggested the presence of novel glycan targets on many of the microorganisms. These results are consistent with interactions previously ascribed to the receptors, but they also highlight binding to additional sugar targets that have not previously been recognized. Our findings indicate that mammalian lectin arrays represent unique discovery tools for identifying both novel ligands and new receptor functions.

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Upham, Jacqueline P., Danielle Pickett, Tatsuro Irimura, E. Margot Anders, and Patrick C. Reading. "Macrophage Receptors for Influenza A Virus: Role of the Macrophage Galactose-Type Lectin and Mannose Receptor in Viral Entry." Journal of Virology 84, no. 8 (January 27, 2010): 3730–37. http://dx.doi.org/10.1128/jvi.02148-09.

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ABSTRACT Although sialic acid has long been recognized as the primary receptor determinant for attachment of influenza virus to host cells, the specific receptor molecules that mediate viral entry are not known for any cell type. For the infection of murine macrophages by influenza virus, our earlier study indicated involvement of a C-type lectin, the macrophage mannose receptor (MMR), in this process. Here, we have used direct binding techniques to confirm and characterize the interaction of influenza virus with the MMR and to seek additional macrophage surface molecules that may have potential as receptors for viral entry. We identified the macrophage galactose-type lectin (MGL) as a second macrophage membrane C-type lectin that binds influenza virus and is known to be endocytic. Binding of influenza virus to MMR and MGL occurred independently of sialic acid through Ca2+-dependent recognition of viral glycans by the carbohydrate recognition domains of the two lectins; influenza virus also bound to the sialic acid on the MMR. Multivalent ligands of the MMR and MGL inhibited influenza virus infection of macrophages in a manner that correlated with expression of these receptors on different macrophage populations. Influenza virus strain A/PR/8/34, which is poorly glycosylated and infects macrophages poorly, was not recognized by the C-type lectin activity of either the MMR or the MGL. We conclude that lectin-mediated interactions of influenza virus with the MMR or the MGL are required for the endocytic uptake of the virus into macrophages, and these lectins can thus be considered secondary or coreceptors with sialic acid for infection of this cell type.

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Baricevic, Ivona, Ljiljana Vicovac-Panic, Vesna Marinovic, and Margita Cuperlovic. "Investigations of asialoglycoprotein receptor glycosylation by lectin affinity methods." Journal of the Serbian Chemical Society 67, no. 5 (2002): 331–38. http://dx.doi.org/10.2298/jsc0205331b.

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The asialoglycoprotein receptor belongs to the family of calcium-dependent (C-type) animal lectins. The purified receptor is a glycoprotein in which 10 % of the dry weight consists of sialic acid, galactose, N-acetylglucosamine and mannose. The carbohydrate content of the asialoglycoprotein receptor was investigated by lectin affinity methods. The usefulness of plant lectin affinity methods in the characterization of the saccharide content of the asialoglycoprotein receptor, as an animal lectin, is demonstrated. RCA I ConA, PHA, SNA I and WGA showed greater affinity toward the asialoglycoprotein receptor, while PSL, AAA and PNA showed negligible interactions with the asialoglycoprotein receptor. The obtained results correlated well with the carbohydrate content of the asialoglycoprotein receptor as determined by chemical methods.

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Karpova, I. S., I. M. Shuba, V. V. Lylo, and O. Y. Glavatskyi. "Characteristics of lectin receptors on erythrocyte membranes of patients with glioblastoma." Faktori eksperimental'noi evolucii organizmiv 34 (September 25, 2024): 165–69. http://dx.doi.org/10.7124/feeo.v34.1634.

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Aim. This work is devoted to the search the abnormalities of the receptor-lectin reactions associated with glioblastoma for diagnostic purposes. Methods. Red blood cell (RBC) specimens were taken from 22 persons distributed into the two cohorts: donors without an oncological diagnosis; patients with glioblastoma (GB). Panel of 9 commercial lectins (LECTINOTEST, Lviv, Ukraine) was used: ConA, WGA, PHA-P; PHA-E; PHA-L, SNA, VAA, STA, and LABA. Also the original lectin from persimmon sepals (named PSL) was used. It was obtained by isoelectric focusing and ammonium sulfate fractionation. Intensity of lectin-receptor interactions was determined in reaction of hemagglutination. Results. Тwo lectins showed some directed divergence in patients from donors. For wheat germ agglutinin (WGA) сhanges in the intensity of lectin-receptor binding were downward. In the case of persimmon L (PSL) the alternative result was observed: the intensity of hemagglutination showed a trend to exceed the level of control. Conclusions. Some individual features in the reaction of erythrocytes with a set of lectins are observed in all examined persons. For two studied lectins, namely WGA and PSL, unidirectional deviations were observed in the reaction of erythrocytes of patients with GB compared to individuals without an oncological diagnosis.

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Hébert, Eric. "Endogenous Lectins as Cell Surface Transducers." Bioscience Reports 20, no. 4 (August 1, 2000): 213–37. http://dx.doi.org/10.1023/a:1026484722248.

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Interactions between cells or between cell and substratum involve specificreceptors and their ligands. Among the various cell surface receptorsidentified during the last decades, the carbohydrate-binding proteins, e.g., lectins are of peculiar interest because glycolipids, glycoproteinsand proteoglycans have been shown to interact with lectins on the surfaceof animal cells. Animal lectins are recognized as molecules playingimportant roles in a variety of biological processes through binding toglycoconjugates and lectin-like receptors such as selectins, sialoadhesins(CD22, CD33), natural killer receptors (NKR-P1, CD69 and CD94/NKG2), hyaluronate receptors (CD44, RHAMM, ICAM-1), B-cell associated antigen(CD23, CD72), γ2 leukocyte integrin (CD11b/CD18) or the well-knownreceptors for mannose, mannose-6-phosphate or asialoglycoprotein havebeen suggested to be able to mediate the transfer of information fromthe outside to the inside of the cell. This review focuses on the mostrecent advances in our understanding of the molecular basis of “outside-in” signaling mediated by lectins. Lectin-likereceptors are involved in signal transduction in a great variety of ways;at the molecular level, they mimic in most of the cases the function ofgrowth factor receptor either coupled to tyrosine kinase activity or toheterotrimeric G protein. They lead to a multiplicity of cellular eventsfollowing their activation depending on factors such as cellular type, species and/or tissue. Nevertheless the potential of surface lectins astransducers is emphasized by the observation that in a few cases lectin-likereceptors induce either novel signal transduction mechanism or newintracellular events with regards to what it has been observed as aconsequence of growth factor receptor activation. This observation bringsthe idea that lectins may offer, as cell surface transducers, an alternativeor additional signaling potential to cell.

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Karpova, I. S. "SPECIFIC INTERACTIONS BETWEEN LECTINS AND RED BLOOD CELLS OF CHORNOBYL CLEANUP WORKERS AS INDICATOR OF SOME LATE RADIATION EFFECTS." Experimental Oncology 38, no. 4 (December 22, 2016): 261–66. http://dx.doi.org/10.31768/2312-8852.2016.38(4):261-266.

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Aim: Growing interest in lectins is based on their diagnostic and pharmacological potential, especially the ability to inhibit proliferation and initiate apoptosis of cancer cells. In our research microplate lectinoassay able to detect carbohydrate containing structures (receptors) on erythrocyte surface have been proposed for Chornobyl cleanup workers (1986) monitoring. It was expected to reveal specific abnormalities associated with pathological condition arising as a result of late radiation effects. Materials and Methods: Red blood cell (RBC) specimens were taken from 171 persons distributed into the six cohorts: nonexposed donors (1); chronically exposed to the doses below (2) and over 50 cGy (3); exposed to acute radiation without (4) and with manifestation of acute radiation syndrome (5 and 6). Lectins from 24 species of medicinal plants were purified by ethanol fractionation and electrofocusing. Intensity of lectin-receptor interactions was determined in reaction of hemagglutination. Method of flow cytofluorometry was used to study B-cell counts. Hormone levels in blood serum were determined by radioimmunoassay. Results: An elevated ability of RBC to interact with the panel of lectins was found in all cohorts of exposed persons versus nonexposed donors, moreover, changes in the intensity of lectin-receptor binding depended on the dose of irradiation. Diagnostic value of specific RBC reactions with some individual lectins has been elucidated. Elevated intensity of RBC reaction with Zea mays lectin was accompanied by a decrease in serum content of thyroid hormones T4 and T3, as well as reduction of B-cell counts. In the case of Rubus caesius lectin the more intensive reaction with RBC, the higher level of hormone cortisol was observed. Conclusions: Deviations from donor’s norm in intensity of lectin — RBC interactions in radiation exposed men are supposed to carry information about negative changes in their health status following Chornobyl catastrophe and show the diagnostic potential. The most sensitive reactions have been associated primarily with shifts in endocrine and immune systems. This article is a part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”.

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Lakhtin, V. M., M. V. Lakhtin, A. Yu Mironov, V. A. Aleshkin, and S. S. Afanasiev. "LECTIN POPULATIONS OF NK CELLS AGAINST VIRUSES-ASSOCIATED TUMORS (REVIEW OF LITERATURE)." Russian Clinical Laboratory Diagnostics 64, no. 5 (October 7, 2019): 314–20. http://dx.doi.org/10.18821/0869-2084-2019-64-5-314-320.

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Analysis of the human NK (natural killers) cells and their functionally different populations in connection to tumor processes accompanied with viral infections is presented. Receptor lectins (non-immunoglobulin proteins and their complexes recognizing polysaccharides, glycoconjugates and glycopattern-containing molecules) play important role in regulation of innate immunity. Communicative diversity of NK-cell populations (in which lectins cofunction to other receptors) is directed against tumors and viruses. Effectiveness and selectivity of action of NK cell populations can be increased in cooperation together with adaptive immunity. Evaluations of occurrence, redistribution (also under influence of cytokines) and contribution of NK-populations (depending on lectin receptors recognition coupled to multifunctions of receptors) in respect of increasing antitumor and antiviral immune responces are given. The data indicate extended prospects of lectin receptors (coupled to other type receptors) containing NK populations of the network compartment of innate immunity upon realization of different variants of organism protection in cooperation with cellular and humoral immunity. Such NK populations are the basis for further intercellular interactions. Innate immunity Cross-Talk, involving the leader NK cell populations acting according to humoral immunity mechanisms, acts on duty regime (importance for therapy of chronic pathology) that results in providing optimal combined antitumor and antiviral cytokine and cytotoxic responses according to the principle of action as «network-in-network». The influence network of lectin, Ig-like, cytotoxic, other regulator NK populations (also throuph redistribution of production of cytokines by immunocompetent cells) is perspective for forming early prolongated antitumor and antiviral processes of different types in organism. It is of importance to consider CD diversity of receptor repertuar of lectin, Ig-like and other NK populations revealing different ontogenesis as well as to seach patient key NK-populations to select and construct personally (or for contingents in cases of epidemiological significance) optimal therapeutic/prophylactic NK populations (like variants of CAR-T). Aforementioned data indicate perspectiveness of NK cell populations in development of new antitumor/antiviral effective and selective vaccine strategies, preparations and regimes of their applications. Probiotic lectins reveal features of perspective ligands cofunctioning to network of NK cell populations.

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Landi, Alessia, Muriel Mari, Svenja Kleiser, Tobias Wolf, Christine Gretzmeier, Isabel Wilhelm, Dimitra Kiritsi, et al. "Pseudomonas aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling." Life Science Alliance 2, no. 6 (November 15, 2019): e201900422. http://dx.doi.org/10.26508/lsa.201900422.

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Lectins are glycan-binding proteins with no catalytic activity and ubiquitously expressed in nature. Numerous bacteria use lectins to efficiently bind to epithelia, thus facilitating tissue colonisation. Wounded skin is one of the preferred niches for Pseudomonas aeruginosa, which has developed diverse strategies to impair tissue repair processes and promote infection. Here, we analyse the effect of the P. aeruginosa fucose-binding lectin LecB on human keratinocytes and demonstrate that it triggers events in the host, upon binding to fucosylated residues on cell membrane receptors, which extend beyond its role as an adhesion molecule. We found that LecB associates with insulin-like growth factor-1 receptor and dampens its signalling, leading to the arrest of cell cycle. In addition, we describe a novel LecB-triggered mechanism to down-regulate host cell receptors by showing that LecB leads to insulin-like growth factor-1 receptor internalisation and subsequent missorting towards intracellular endosomal compartments, without receptor activation. Overall, these data highlight that LecB is a multitask virulence factor that, through subversion of several host pathways, has a profound impact on keratinocyte proliferation and survival.

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Barre, Annick, Els J. M. Van Damme, Mathias Simplicien, Sophie Le Poder, Bernard Klonjkowski, Hervé Benoist, David Peyrade, and Pierre Rougé. "Man-Specific Lectins from Plants, Fungi, Algae and Cyanobacteria, as Potential Blockers for SARS-CoV, MERS-CoV and SARS-CoV-2 (COVID-19) Coronaviruses: Biomedical Perspectives." Cells 10, no. 7 (June 28, 2021): 1619. http://dx.doi.org/10.3390/cells10071619.

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Betacoronaviruses, responsible for the “Severe Acute Respiratory Syndrome” (SARS) and the “Middle East Respiratory Syndrome” (MERS), use the spikes protruding from the virion envelope to attach and subsequently infect the host cells. The coronavirus spike (S) proteins contain receptor binding domains (RBD), allowing the specific recognition of either the dipeptidyl peptidase CD23 (MERS-CoV) or the angiotensin-converting enzyme ACE2 (SARS-Cov, SARS-CoV-2) host cell receptors. The heavily glycosylated S protein includes both complex and high-mannose type N-glycans that are well exposed at the surface of the spikes. A detailed analysis of the carbohydrate-binding specificity of mannose-binding lectins from plants, algae, fungi, and bacteria, revealed that, depending on their origin, they preferentially recognize either complex type N-glycans, or high-mannose type N-glycans. Since both complex and high-mannose glycans substantially decorate the S proteins, mannose-specific lectins are potentially useful glycan probes for targeting the SARS-CoV, MERS-CoV, and SARS-CoV-2 virions. Mannose-binding legume lectins, like pea lectin, and monocot mannose-binding lectins, like snowdrop lectin or the algal lectin griffithsin, which specifically recognize complex N-glycans and high-mannose glycans, respectively, are particularly adapted for targeting coronaviruses. The biomedical prospects of targeting coronaviruses with mannose-specific lectins are wide-ranging including detection, immobilization, prevention, and control of coronavirus infection.

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Дисертації з теми "Lectin receptor"

Kerscher, Berhard Gerhard Richard. "Characterisation of the C-type lectin receptor Clecsf8." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230779.

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C-type lectin-like receptors (CTLRs) play critical roles in immunity and homeostasis by recognising a variety of microbial or endogenous ligands. Clecsf8 is a member of the Dectin-2 family of CTLRs. Clecsf8 shares important similarities with its relatives Mincle and Dectin-2, such as the lack of an integral signalling motif and a single, calcium dependent ligand binding domain. They were shown to associate with the FcRγ adaptor, which is essential for receptor surface expression and downstream signalling. Recent publications revealed an important role for Clecsf8 in anti-mycobacterial immunity. It was reported to recognise the mycobacterial cord factor (TDM), similar to the related CTLR Mincle, as well as a possible role in candidiasis. In this study, we characterised the underlying mechanism of Clecsf8 expression in a context of mycobacterial disease. The generation of novel anti-Clecsf8 monoclonal antibodies allowed us to characterise the expression of Clecsf8 in detail in homeostasis and inflammation in murine models in vivo and culture systems in vitro. We found Clecsf8 to be predominantly expressed on monocytes/macrophages and neutrophils within e. g. the peritoneal cavity, blood and bone marrow. Notably, Clecsf8 was expressed only weakly in the lung, but strongly upregulated in a pulmonary mycobacterial infection model. In vitro, Clecsf8 expression on elicited macrophages was strongly induced upon treatment with microbial stimuli in a Myd88- and Mincle dependent manner. Interestingly, surface expression of Clecsf8 in a murine fibroblast cell line was greatly enhanced by co-transfection of Mincle, but not another related CTLR, Dectin-2. Notably, we confirmed mycobacteria as a ligand of CLECSF8, but found no role for the receptor in Candida immunity. In conclusion, Clecsf8 is a myeloid expressed, mycobacterial receptor, showing significant interdependence with Mincle and is regulated through the Myd88 pathway.

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Nassanian, Hoorig. "The biology of the C-Type lectin receptor DC-SIGN." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1627802281&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Clark, Alexandra Elsie. "Characterisation of the C-type lectin-like receptor 1 (CLEC-1)." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=210080.

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Marshall, Andrew. "The characterisation of a novel C-type lectin-like receptor MICL." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409114.

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Huysamen, Cristal. "The characterization of a novel C-type lectin-like receptor, CLEC9A." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/3060.

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Murase, Takatoshi. "Identification of soluble forms of lectin-like oxidized LDL receptor-1." Kyoto University, 2004. http://hdl.handle.net/2433/148276.

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Rumjantseva, Viktoria. "Dual roles for hepatic lectin receptors in the clearence of chilled platelets /." Göteborg : Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine, The Sahlgrenska Academy, University of Gothenburg, Department of Translational Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Göteborg and Boston, 2009. http://hdl.handle.net/2077/21173.

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Rogers, Sarah Louise. "Characterisation of C-type lectin-like receptor genes in the chicken MHC." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271871.

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Souto, Maior Mourão Sá D. "Characterisation of the C-type lectin receptor CLEC-2 : expression, ligands and functions." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1302407/.

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Myeloid cells express a plethora of C-type lectin receptors (CLR) that can regulate inflammatory responses. Dectin-1 belongs to a sub-family of CLRs that possesses an extracellular C-type lectin domain (CTLD) and a single YxxL intracellular motif (hemITAM) that allows signalling via Syk kinase and induction of downstream functions. Based on consensus sequences for the CTLD and hemITAM, we identified CLEC-2 as a dectin-1-like receptor. CLEC-2 was previously characterised as a Syk-coupled platelet receptor able to induce platelet aggregation when targeted by the snake venom rhodocytin and by cells expressing the endogenous protein podoplanin. I generated monoclonal antibodies against mouse CLEC-2 and found that CLEC-2 is also expressed on lymphoid and myeloid cells, including dendritic cells (DC). Notably, treatment with LPS increases CLEC-2 expression by myeloid cells and synergises with CLEC-2 signaling to induce increased secretion of IL-10 but not IL-12. This increased IL-10 production is also observed in the serum of mice administered with anti-CLEC-2 mAb and LPS, and is dependent on the presence of macrophages and DCs. Furthermore, I generated a CLEC-2 conditional KO mouse line that will provide a tool to study CLEC-2 function in myeloid cells in vivo. Collectively, these data indicate that CLEC-2 expression is not restricted to platelets and that it plays a role on the vascular development and modulation of TLR responses.

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Tessmer, Marlowe S. "Biological functions and molecular associations of the killer cell lectin-like receptor G1." View abstract/electronic edition; access limited to Brown University users, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3318364.

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Книги з теми "Lectin receptor"

Milad, Abubaker Marouf. Degradation of the human erythrocite receptor for Dolichus biflorus lectin by endo-beta-galactosidase: A thesis. Portsmouth: University of Portsmouth, School of Pharmacy and Biomedical Sciences, 1995.

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Yamasaki, Sho, ed. C-Type Lectin Receptors in Immunity. Tokyo: Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-56015-9.

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Yue, Kay-Tsz. The effects of lectins on recombinant glutamate receptors. Ottawa: National Library of Canada, 1994.

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Yamasaki, Sho. C-Type Lectin Receptors in Immunity. Springer, 2018.

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Yamasaki, Sho. C-Type Lectin Receptors in Immunity. Springer Japan, 2016.

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Yue, Kay-Tsz. The effects of lectins on recombinant glutamate receptors. 1995.

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Michelson, David A. The Library of Paradise. Oxford University PressOxford, 2022. http://dx.doi.org/10.1093/oso/9780198836247.001.0001.

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Abstract This book tells the story of contemplative reading, a spiritual discipline practiced in the Syriac Christian monasteries of the Church of the East in sixth- and seventh-century Mesopotamia. These ascetics practiced a form of contemplation which moved from reading, to meditation, to prayer, to the ecstasy of divine vision. The book proceeds in two parts. The first part crafts a methodology. The second, longer part is an historical narrative of the development, definition, and diffusion of contemplative reading. The book adapts methodological insights from prior scholarship on the history of reading, including studies on early medieval lectio divina. Another methodological chapter undertakes a cautionary case study of the British Library manuscript collection and identifies how future scholarship can overcome cultural and racial prejudices which have sometimes obscured the history of Syriac monastic readers from view. The second half of the book employs this methodology to narrate the evolution of East Syrian contemplative reading over three historical phases: the establishment of the practice, the articulation of its theology, and the maturation and spread of the tradition. Individual chapters focus on the role of ascetic reading in the monastic reform of Abraham of Kashkar, the commentaries on Evagrius of Pontus written by Babai the Great, and the monastic handbooks of ʿEnanishoʿ of Adiabene and Dadishoʿ of Qatar. A concluding chapter points the way forward for further scholarship by noting the long legacy of East Syrian contemplative reading through its reception into Sogdian, Arabic, and Ethiopic monastic libraries.

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Cónsole-Avegliano, Gloria Miriam. Embriología molecular de las cardiopatías congénitas. Editorial de la Universidad Nacional de La Plata (EDULP), 2018. http://dx.doi.org/10.35537/10915/71653.

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La presente obra pretende integrar aspectos embriológicos, genéticos y moleculares del desarrollo cardíaco humano normal y patológico. Se han reunido trabajos de embriólogos, genetistas, especialistas en imágenes, pediatras y cirujanos pediátricos involucrados en el tratamiento de las cardiopatías congénitas. La obra aporta una exhaustiva revisión de la Embriología cardíaca humana clásica y molecular que conlleva a una mejor comprensión del desarrollo de las principales cardiopatías congénitas. Además, resulta de interés conocer los nuevos genes involucrados en la cardiogénesis y analizar los programas de expresión génica cámara-específicos mediados por los factores de transcripción y las moléculas receptoras. En el ciclo lectivo 1965 comencé a enseñar Embriología Humana como Ayudante alumna de la Cátedra de Biología-Embriología a cargo del Prof. Dr. Herberto Prieto Díaz y desde entonces, siento especial inclinación por el estudio embriológico y por los avances moleculares y genéticos que se han incorporado. Hice mi aporte al tema al redactar el capítulo 18: Desarrollo del corazón y grandes vasos de la obra Embriología Humana (Atlas y Texto) del maestro Prof. Dr. César L.A. Gómez Dumm (2003). Con esta obra deseo presentar los avances moleculares, genéticos y de terapia génica para que los profesionales de la salud actualicen sus conocimientos sobre los procesos del desarrollo cardíaco y optimicen las estrategias terapéuticas.

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Luna Sevcik, José Elías, Gabriela Natasha Luna Noboa, Rafael Antonio Avecillas Segovia, Juan Carlos Olvera Triviño, Claudia Valeria Yerovi Villacrés, Luis Carlos Demera Demera, Karla Alexandra Tacuri Burgos, Katiuska Vanessa Suriaga Ramírez, Cristian David Sánchez León, and Danilo Alexis García Contreras. Cirugía Plástica. Mawil Publicaciones de Ecuador, 2020, 2020. http://dx.doi.org/10.26820/978-9942-826-29-9.

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En el campo de las ciencias médicas, reconocer la importancia de la tecnología como fuente de trabajo, lleva a los diferentes especialistas, en particular al cirujano plástico mirar su hacer diario, desde una perspectiva transformadora e innovadora; donde el cuerpo humano, afianza sus conocimientos de forma integral, para generar en las personas cambios importantes que permitan en sus pacientes incrementar la autoestima, involucrarse desde su yo como un eje que les da posibilidades de tener nuevas oportunidades a participar en cada actividad diaria, laboral, familiar y personal propuesta. Del texto anterior, se desprende la importancia que presenta la cirugía plástica en este siglo XXI, al considerar al cuerpo humano como un receptor de posibles transformaciones, que llevan a dicha área científica al reconocimiento de los estudios genéticos, trasplantes de tejidos, abordaje de quemaduras, lesiones cutáneas, manejo de las diferentes patología que ameritan una modificación armónica para darle al paciente un reencuentro con su nuevo estilo de vida. Todo ello, permite hoy concebir el trabajo del cirujano plástico desde una óptica reconstructiva en estructuras anormales del cuerpo originadas por defectos congénitos, anomalías del desarrollo, traumatismos, infecciones y enfermedades entre otros. Quiero decir que estas ideas, han sido una inspiración personal, las cuales desde hace mucho tiempo, se convierten en pensamientos inconscientes que me llevan a recopilar toda la información para finalmente presentar este libro como resultado de mi experiencias y deseos de indicar nuevas interpretaciones centradas en la recopilación de toda la indagación para plasmar cada una de las argumentaciones que dan vida a dicha producción científica, Por ello, su contenido no tiene una dedicación en particular, simplemente miro el horizonte y recojo la necesidad de indicar a través de mi trabajo de lector, escritor e intérprete aquellos planteamientos anteriores para convertirlos en evidencias nuevas que surgen continuamente, de ese modo, ofrecerlas a cualquier cirujano; pero al mismo tiempo a los individuos interesados en el contenido temático que expongo.

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Частини книг з теми "Lectin receptor"

Kim, Cheorl-Ho. "C-Type Lectin (C-Type Lectin Receptor)." In Glycobiology of Innate Immunology, 497–555. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-9081-5_8.

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van Roy, Frans, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, et al. "C-type Lectin-Like Receptor 1." In Encyclopedia of Signaling Molecules, 481. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100323.

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van Roy, Frans, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, et al. "C-type Lectin-Like Receptor 2." In Encyclopedia of Signaling Molecules, 481. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100324.

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Suzuki-Inoue, Katsue. "C-Type Lectin-Like Receptor 2 (CLEC-2)." In C-Type Lectin Receptors in Immunity, 83–98. Tokyo: Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-56015-9_6.

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Kaifu, Tomonori, and Yoichiro Iwakura. "Dendritic Cell Immunoreceptor (DCIR): An ITIM-Harboring C-Type Lectin Receptor." In C-Type Lectin Receptors in Immunity, 101–13. Tokyo: Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-56015-9_7.

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López-Botet, M., M. Carretero, T. Bellón, J. J. Pérez-Villar, M. Llano, and F. Navarro. "The CD94/NKG2 C-Type Lectin Receptor Complex." In Specificity, Function, and Development of NK Cells, 41–52. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-46859-9_4.

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Gupta, Anita. "Asialoglycoprotein Receptor and the Macrophage Galactose-Type Lectin." In Animal Lectins: Form, Function and Clinical Applications, 709–24. Vienna: Springer Vienna, 2012. http://dx.doi.org/10.1007/978-3-7091-1065-2_33.

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Hanč, Pavel, Salvador Iborra, Santiago Zelenay, Janneke van Blijswijk, David Sancho, and Caetano Reis e Sousa. "DNGR-1, an F-Actin-Binding C-Type Lectin Receptor Involved in Cross-Presentation of Dead Cell-Associated Antigens by Dendritic Cells." In C-Type Lectin Receptors in Immunity, 65–81. Tokyo: Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-56015-9_5.

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Vaid, Neha, Prashant K. Pandey, and Narendra Tuteja. "Lectin Receptor-Like Kinases and Their Emerging Role in Abiotic Stress Tolerance." In Abiotic Stress Response in Plants, 207–20. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2016. http://dx.doi.org/10.1002/9783527694570.ch10.

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Costa Mendonça-Natividade, Flávia, Rafael Ricci-Azevedo, and Maria Cristina Roque-Barreira. "MIC4 from Toxoplasma gondii: A Lectin Acting as a Toll-Like Receptor Agonist." In Methods in Molecular Biology, 379–89. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0430-4_37.

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Тези доповідей конференцій з теми "Lectin receptor"

Berger, Dave. "Maize lectin receptor-like kinase: a putative vel immune receptor against the fungus Cercospora zeina." In ASPB PLANT BIOLOGY 2020. USA: ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1053017.

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Ray, Andrew, Morohunfolu Akinnusi, and Ali A. El Solh. "Lectin-Like Oxidized LDL Receptor-1 Modulates Endothelial Apoptosis In Obstructive Sleep Apnea." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2220.

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Qiao, Zhenzhen. "Towards engineering beneficial mycorrhization into bioenergy crop Switchgrass via a lectin receptor-like kinase." In ASPB PLANT BIOLOGY 2020. USA: ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1061833.

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Ahmed, M., L. J. Richwalls, N. Constantinesco, M. A. Marinelli, R. Gopal, and J. F. Alcorn. "The Lectin Receptor CD209d/e Is Required for Methicillin Resistant Staphylococcus Aureus Pulmonary Host Defense." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1260.

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Campagnoli, Susanna, Matteo Parri, Alberto Grandi, Elisa De Camilli, Luigi Terracciano, Boquan Jin, Giuseppe Viale, et al. "Abstract C165: Discovery of a lectin-like receptor family protein as a novel target for monoclonal antibody therapy." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Oct 19-23, 2013; Boston, MA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1535-7163.targ-13-c165.

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Lax, Sian, Julie Rayes, David Thickett, and Steve Watson. "LSC Abstract – The role of platelet-expressed C-type lectin-like receptor-2 in regulating the severity of murine lung injury." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa936.

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Bienz, D., T. Wager, and K. J. Clemetson. "ISOLATION AND CHARACTERIZATION OF HUMAN PLATELET MEMBRANE GLYCOPROTEINS Ia AND IIa." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643910.

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Glycoproteins (GP) Ia and IIa are relatively minor components of the platelet surface with similar molecular properties. Nieuwenhuis et al. (Nature 319, 470-72, 1985) described a patient whose platelets show no response to collagen. The correlating lack of GPIa in the platelets of this patient suggests this glycoprotein being the receptor for collagen. Santoro (Cell, 46, 913-20, 1986) described a 160 kDa glycoprotein that binds to collagen in the presence of MG2 + and is possibly identical with GPIa. The role of GPIIa is still unknown but a similar molecule has also been found on endothelial cells. It has been suggested that GPIa and GPIIa are complexed with a further membrane component GPIc. The two glycoproteins show only slight difference in molecular weight, isoelectric point and in their affinity for various lectins. As a result they coisolate using most separation techniques.GPIa is usually associated with the cytoskeleton while GPIIa is mostly found in the soluble phase. GPIa is dissociated from the cytoskeleton by addition of 2% SDS (final conc.) and sonication. Performing Triton X-114 phase partition, GPIIa is found in the detergent phase. After the detergents of the GPIa and GPIIa enriched protein solutions are exchanged with the non-ionic octanoyl-N-methyl glucamide, the glycoproteins are further purified by affinity chromatography on wheat germ agglutinin-Sepharose followed by Lens culinaris lectin-Sepharose both of which bind GPIa and GPIIa. A major contaminant during the purification is GPIb. Final purification of GPIa and GPIIa was obtained by preparative SDS-PAGE using electroelution into a membrane trap. Latest results show an enrichment of GPIa and a lack of GPIb in pseudopodes, isolated by the method of Rotman et al. (Proc. Natl. Acad. Sci. USA, 4357-61, 1982).

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Meegan, J. E., J. S. Douglas, K. J. Riedmann, L. B. Ware, and J. A. Bastarache. "Hemoglobin-mediated Oxidation of Low-density Lipoprotein (oxLDL) Contributes to Lung Microvascular Endothelial Dysfunction Via Lectin-like Oxidized LDL Receptor 1 (LOX-1)." In American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5149.

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Maeda, Michihide, Seiji Mabuchi, Mina Sakata, Satoki Deguchi, Reisa Kakubari, Shinya Matsuzaki, Tsuyoshi Hisa, and Shoji Kamiura. "PR036/#843 C-reactive protein promotes the progression of cervical cancer by stimulating lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1)." In IGCS 2024 Annual Meeting Abstracts, A60.1—A60. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/ijgc-2024-igcs.78.

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Звіти організацій з теми "Lectin receptor"

Fluhr, Robert, and Maor Bar-Peled. Novel Lectin Controls Wound-responses in Arabidopsis. United States Department of Agriculture, January 2012. http://dx.doi.org/10.32747/2012.7697123.bard.

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Innate immune responses in animals and plants involve receptors that recognize microbe-associated molecules. In plants, one set of this defense system is characterized by large families of TIR–nucleotide binding site–leucine-rich repeat (TIR-NBS-LRR) resistance genes. The direct interaction between plant proteins harboring the TIR domain with proteins that transmit and facilitate a signaling pathway has yet to be shown. The Arabidopsis genome encodes TIR-domain containing genes that lack NBS and LRR whose functions are unknown. Here we investigated the functional role of such protein, TLW1 (TIR LECTIN WOUNDRESPONSIVE1). The TLW1 gene encodes a protein with two domains: a TIR domain linked to a lectin-containing domain. Our specific aim in this proposal was to examine the ramifications of the TL1-glycan interaction by; A) The functional characterization of TL1 activity in the context of plant wound response and B) Examine the hypothesis that wounding induced specific polysaccharides and examine them as candidates for TL-1 interactive glycan compounds. The Weizmann group showed TLW1 transcripts are rapidly induced by wounding in a JA-independent pathway and T-DNA-tagged tlw1 mutants that lack TLW1 transcripts, fail to initiate the full systemic wound response. Transcriptome methodology analysis was set up and transcriptome analyses indicates a two-fold reduced level of JA-responsive but not JA-independent transcripts. The TIR domain of TLW1 was found to interact directly with the KAT2/PED1 gene product responsible for the final b-oxidation steps in peroxisomal-basedJA biosynthesis. To identify potential binding target(s) of TL1 in plant wound response, the CCRC group first expressed recombinant TL1 in bacterial cells and optimized conditions for the protein expression. TL1 was most highly expressed in ArcticExpress cell line. Different types of extraction buffers and extraction methods were used to prepare plant extracts for TL1 binding assay. Optimized condition for glycan labeling was determined, and 2-aminobenzamide was used to label plant extracts. Sensitivity of MALDI and LC-MS using standard glycans. THAP (2,4,6- Trihydroxyacetophenone) showed minimal background peaks at positive mode of MALDI, however, it was insensitive with a minimum detection level of 100 ng. Using LC-MS, sensitivity was highly increased enough to detect 30 pmol concentration. However, patterns of total glycans displayed no significant difference between different extraction conditions when samples were separated with Dionex ICS-2000 ion chromatography system. Transgenic plants over-expressing lectin domains were generated to obtain active lectin domain in plant cells. Insertion of the overexpression construct into the plant genome was confirmed by antibiotic selection and genomic DNA PCR. However, RT-PCR analysis was not able to detect increased level of the transcripts. Binding ability of azelaic acid to recombinant TL1. Azelaic acid was detected in GST-TL1 elution fraction, however, DHB matrix has the same mass in background signals, which needs to be further tested on other matrices. The major findings showed the importance of TLW1 in regulating wound response. The findings demonstrate completely novel and unexpected TIR domain interactions and reveal a control nexus and mechanism that contributes to the propagation of wound responses in Arabidopsis. The implications are to our understanding of the function of TIR domains and to the notion that early molecular events occur systemically within minutes of a plant sustaining a wound. A WEB site (http://genome.weizmann.ac.il/hormonometer/) was set up that enables scientists to interact with a collated plant hormone database.

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