Дисертації з теми "Laser desorption ionization MS"
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Tummala, Manorama. "Surfactant-Aided Matrix Assisted Laser Desorption/Ionization Mass Spectrometry (SA-MALDI MS)." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100672049.
Повний текст джерелаSorensen, Christina M. "ESI-MS and MALDI-TOF-MS for the characterization and analysis of metallo-oligomers and proteins." Laramie, Wyo. : University of Wyoming, 2005. http://proquest.umi.com/pqdweb?did=1031044031&sid=4&Fmt=2&clientId=18949&RQT=309&VName=PQD.
Повний текст джерелаSegu, Mohideen Mohamed Zaneer. "TARGET MODIFICATION FOR ENHANCED PERFORMANCE MATRIX ASSISTED LASER DESORPTION IONIZATION (MALDI) MASS SPECTROMETRY." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1674093101&sid=1&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Повний текст джерела"Department of Chemistry." Keywords: Enhanced MALDI, MALDI-MS, On-probe separation, Protein-surface interactions, Sublayers, Surface binding capacity. Includes bibliographical references (p. 130-148). Also available online.
Ratcliffe, Lucy Vivien. "Proteomic strategies for protein and biomarker identification by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS)." Thesis, Nottingham Trent University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431885.
Повний текст джерелаPENG, LIJUAN. "MATRIX-ASSISTED LASER DESORPTION/IONIZATION (MALDI) TARGET MODIFICATION FOR ENHANCED PROTEOMICS ANALYSIS AND PLASMA POLYMER CHARACTERIZATION BY MALDI MASS SPECTROMETRY." OpenSIUC, 2010. https://opensiuc.lib.siu.edu/dissertations/207.
Повний текст джерелаYao, Mengmeng. "Determining Polymer Blend Surface Concentration Using Surface Layer Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry (SL-MALDI-TOF MS)." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1407941345.
Повний текст джерелаHill, Jacob A. Hill. "SURFACE LAYER MATRIX-ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY (SL-MALDI-TOF MS) ANALYSIS OF POLYMER BLEND SURFACE COMPOSITION." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1514479406062149.
Повний текст джерелаThenstedt, Niklas. "Detektion av hydrolyserad β-laktamantibiotika i plasma med Matrix-Assisted Laser Desorption Ionization – Time of Flight Mass Spectrometry och Liquid Chromatography tandem Mass Spectrometry". Thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84594.
Повний текст джерелаIntroduction Antibiotic resistance is a global growing problem. Piperacillin-tazobactam and cefotaxime are parts of the group β-lactam antibiotics. The common feature is to inhibit the cell wall synthesis by covalent bindings to the peptidoglycan layer and thereby causing lysis of the bacterial cell. E. coli and K. pneumoniae are members of the Enterobacteriaceae which is a part of the human normal flora but also are commonly associated with urinary tract infections which sometimes develops into to sepsis. Extended Spectrum β-Lactamases (ESBLs) are enzymes with hydrolytic abilities acting on β-lactam antibiotics, expressed by Enterobacteriaceae. The qualitative, Matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) can be used to detect chemical compounds in the ratio of mass to charge in accordance to their molecular weight. Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) is a highly sensitive two-step method of quantification which first separate molecules by their polarity attraction force and then by the ratio of mass to charge. Aim The aim of this study was to develop a fast and efficient method to determine degradation of piperacillin-tazobactam and cefotaxime in blood plasma by LC-MS/MS. Method Tenfold dilution of piperacillin-tazobactam in concentrations of 2000 to 2 µg/ml, and cefotaxime in concentrations of 500 to 0,5 µg/ml where analyzed by MALDI-TOF MS, intact and also with the bacteria E. coli and K. pneumoniae with different expression of antibiotic resistance. Optimized concentrations where fixed in blood plasma and then quantified by LC-MS/MS. Result The detection limit by using MALDI TOF MS of hydrolyzed as well as non-hydrolyzed piperacillin-tazobactam was 20/2,5 µg/ml. The detection limit in cefotaxime was 5 µg/ml. Hydrolysis could not be detected in clinically fixed blood concentrations. Detection and quantification of hydrolysis by LC-MS/MS was possible in a concentration of three bacteria colonies/50 µl. Conclusion It is possible to detect hydrolysis in both MALDI TOF MS and LC-MS/MS. A larger amount of bacteria than expected was needed to demonstrate hydrolysis In LC-MS/MS.
Huang, Huan. "Optimizing Deposition of Matrix and Ionization Salt via Two-Step Sublimation in Sample Preparation for Surface-Layer Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging (SL-MALDI-TOF MSI)." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1619183035472425.
Повний текст джерелаGuerreiro, Tatiane Melina 1987. "Análise de marcadores químicos de adulteração de vinagre balsâmico por 'silica plate laser desorption/ionization mass spectrometry' (SP-LDI-MS)." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313028.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: O Vinagre Balsâmico é um produto italiano de grande valor, bastante apreciado em todo o mundo devido ao seu sabor característico e aos seus potenciais benefícios à saúde. Ao longo dos últimos anos, diversos pesquisadores realizaram estudos que avaliaram a sua composição físico-química, microbiana e suas propriedades benéficas. Devido ao alto número de estudos que confirmam o seu caráter antioxidante e suas propriedades anti-hipertensivas e antiglicêmicas, o vinagre balsâmico é um produto alvo de fraudes e adulterações. Desta forma, há uma preocupação acerca dos balsâmicos autênticos, que possuam certificação tanto para sua origem (região ou país), como para suas condições de processamento, garantindo sua qualidade e originalidade. Por isso, o esforço para a redução de fraudes, bem como a garantia da qualidade dos balsâmicos são de grande interesse tanto para saúde do consumidor, quanto do ponto de vista econômico. Buscando encontrar estratégias analíticas confiáveis, capazes de avaliar rapidamente a qualidade do vinagre balsâmico, este trabalho emprega a técnica de Espectrometria de Massas por Ionização/Dessorção a Laser em Placa de Sílica (SP-LDI-MS) para a rápida caracterização química de amostras de vinagres balsâmicos comercial e com indicação geográfica protegida (IGP), e identificação de suas amostras adulteradas com vinagres de baixo custo, provenientes de maçã, álcool e vinhos branco e tinto
Abstract: The Balsamic Vinegar is a valuable Italian product, very popular worldwide due to its distinctive flavor and potential health benefits. Several studies have been conducted to assess physicochemical and microbial compositions as well as with respect to its beneficial properties. Due to the high number of studies that confirm its antioxidant character and their antihypertensive and antiglycemic properties, balsamic vinegar is a potential target for frauds and adulterations. Thus, there is growing concern about the search for authenticated balsamics, so make sure your origin (region or country) as well as their processing conditions, which guarantee quality and originality of balsamic vinegar. Striving for fraud reduction and ensuring the quality and safety of food through reliable analytical strategies to quickly assess the quality of balsamic vinegar are of great interest to health and the economic point of view. In this context, this work employs the technique of Silica Plate Laser Desorption/Ionization Mass Spectrometry (SP-LDI-MS) for rapid chemical characterization of samples of commercial balsamic vinegars and with protected geographical indications (PGI) and identification their samples adulterated with inexpensive vinegars from apple, alcohol and red and white wines
Mestrado
Fisiopatologia Médica
Mestra em Ciências
Ochoa, Mariela L. "Forensic and Proteomic Applications of Thermal Desorption Ion Mobility Spectrometry and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry." Ohio University / OhioLINK, 2005. http://www.ohiolink.edu/etd/view.cgi?ohiou1113585811.
Повний текст джерелаSaad, Bessem. "Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry som verktyg för att detektera nedbrytning av Ceftolozan/Tazobaktam orsakad av karbapenemaser." Thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84598.
Повний текст джерелаIn recent years, an alarming increase of antibiotic resistance has been observed in Gram-negative bacteria, classified in the family Enterobacteriaceae. The main resistance mechanism is the production of extended-spectrum β-lactamases (ESBL). Particularly worrisome is the production of carbapenemases (ESBLCARBA) due to their ability to hydrolyze a broad range of β-lactams. Recently, Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) has been investigated as a method for rapid detection of carbapenemase activity through observation of antibiotic degradation. The aim of this study was to investigate whether MALDI-TOF MS can be used as a method to detect degradation of Ceftolozane/Tazobactam as well as to examine which enzymes that possess the ability to hydrolyze the antibiotic. A total of seven carbapenemase-producing strains were used in the study. The experiment also included a β-lactamase-negative isolate as a negative control. The strains were incubated with antibiotic (1mg/ml) in a buffered solution (0,08% ammonium bicarbonate, pH 8) for 120 min and 270 min. The supernatant, after centrifugation, was analyzed by MALDI-TOF MS. All the carbapenemase-producing strains demonstrated hydrolysis of Ceftolozane, except for NDM-1 producing E. coli. However, mass peaks corresponding to the degradation of Tazobactam were only detected in strains producing OXA-48 and NDM-7. The degradation of Ceftolozane/Tazobactam was most apparent after 120 minutes. However, to better enable detection of mass peaks, further optimization is needed in regard to appropriate matrix, buffer and antibiotic concentration.
Chen, Ping. "Applications of Chemometric Algorithms to Ion Mobility Spectrometry and Matrix Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry." Ohio University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1206019463.
Повний текст джерелаTate, Wendy Rose. "Surface-enhanced laser desorption/ionization time-of-flight mass spectroscopy (SELDI-TOF-MS) as a tool for molecular endpoint analysis of PX-12, a thioredoxin-1 inhibitor." Thesis, The University of Arizona, 2005. http://hdl.handle.net/10150/291852.
Повний текст джерелаÅminne, Ann. "Evaluation of preanalytic methods in order to shorten the processing time before identification of fungal microorganisms by the MALDI-TOF MS." Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-255132.
Повний текст джерелаOsterhage, Katharina Johanna [Verfasser]. "Die Zuverlässigkeit von MALDO-TOF MS (Matrix Assisted Laser Desorption / Ionization Time-of-Flight Mass Spectrometry) als Verfahren zur Identifikation von Acinetobacter spp. [[Elektronische Ressource]] / Katharina Johanna Osterhage." Köln : Deutsche Zentralbibliothek für Medizin, 2010. http://d-nb.info/1000932451/34.
Повний текст джерелаRettinger, Anna Lena. "Anwendbarkeit der Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) für den Nachweis und die Differenzierung von Leptospira spp. im Vergleich zum Multilocus Sequence Typing (MLST)." Diss., lmu, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-154644.
Повний текст джерелаJung, Seokwon. "Surface characterization of biomass by imaging mass spectrometry." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45906.
Повний текст джерелаJacksén, Johan. "Improved techniques for CE-MALDI-MS off-line coupling and MALDI-MS analysis of primarily hydrophobic proteins and peptides." Licentiate thesis, KTH, Chemistry, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4599.
Повний текст джерелаDue to the hydrophobic nature of integral membrane proteins (IMP) they give rise to several difficulties concerning handling and analysis, which is not the case for the most water soluble proteins. New analysis methods are needed, where the insolubility problems of the hydrophobic proteins due to aggregation and adhesion are tackled. Those problems also affect digestion performance and equipment compatibility for the analysis.
Protocols for analysis and separation specified for IMP are presented in Paper I and III.
The instrumentation used in this work was capillary electrophoresis (CE) and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). Both instruments are suitable for peptide/proteins analysis.
In Paper I, protocols for a CE separation of bacteriorhodopsin (BR) peptides as model IMP peptides are established. Also, a partially automated manufacturing procedure of a concentration MALDI-target is presented, suitable for fractions from CE. The MS analysis detected 9 out of 10 cyanogen bromide (CNBr) digested BR peptides. A novel technique for the off-line integration of CE to MALDI-MS using a closed-open-closed system is presented in Paper II, where the open part is a microcanal functioning as a MALDI target window. Investigation of the microcanal electro-osmotic flow (EOF) properties and band broadening characteristics was performed. A protein separation was obtained and detected with MALDI-MS analysis in the microcanal. Different protein digestion methods were evaluated using BR in Paper III through MALDI-MS. Several digestion methods as well as MS media were investigated alongside different MALDI matrices. For example, matrices as the hydrophobic 2,6-dihydroxyacetophenone (DHAP) and 2-Hydroxy-3-methoxybenzoic acid (2H3MBA) or 2-Hydroxy-5-methoxybenzoic acid (2H5MBA) mixed with DHB, appeared to be promising matrices for analysis of BR.
Med anledning av integrala membranproteiners (IMP) hydrofoba egenskaper uppstår flera svårigheter vid hantering och analys av IMP, vilket inte är fallet för vattenlösliga proteiner. Nya analysmetoder krävs, som löser löslighetsproblemen för de hydrofoba proteinerna som tex flockning och adsorbtion. Dessa problem påverkar även klyvningsgrad och kompatibilitet med analysutrustningen.
I Artikel I och Artikel III presenteras protokoll för analys och separation specifikt för IMP. Instrumenteringen som har använts i detta arbete är kapillärelektrofores (CE) och matris-assisterad laserdesorptions-joniserings-masspektrometri (MALDI-MS). Båda instrumenten är lämpade för peptid/protein analyser.
I Artikel I, presenteras protokoll för en CE separation av peptider från bacteriorhodopsin (BR), som användes som modellpeptider för IMP. En delvis automatiserat tillverkningsprocedur för en koncentrerande MALDI-platta, som är anpassad för CE fraktionerna beskrivs också. MS-analysen detekterade 9 av 10 BR-peptider från cyanobromid-klyvning (CNBr). En ny teknik för off line-integrering av CE till MALDI-MS genom ett slutet-öppet-slutet system presenteras i Artikel II, där den öppna delen är en mikrokanal som fungerar som detektionsfönster i MALDI. Undersökning av mikrokanalens egenskaper som tex det elektroosmotiska flödet (EOF) och bandbreddningen utvärderades. En proteinseparation genomfördes och detekterades med MALDI–MS i mikrokanalen. Olika proteinklyvningsmetoder för BR undersöktes i Artikel III med MALDI-MS. Flera proteinklyvningsmetoder samt MS-medier utvärderades tillsammans med olika MALDI-matriser. Den hydrofoba matrisen 2,6-dihydroxyacetophenone (DHAP) och 2-Hydroxy-3-methoxybenzoic acid (2H3MBA) eller 2-Hydroxy-5-methoxybenzoic acid (2H5MBA) blandade med DHB, visade sig exempelvis vara lovande matriser för BR-analyser.
Rettinger, Anna Lena [Verfasser], and Reinhard [Akademischer Betreuer] Straubinger. "Anwendbarkeit der Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) für den Nachweis und die Differenzierung von Leptospira spp. im Vergleich zum Multilocus Sequence Typing (MLST) / Anna Lena Rettinger. Betreuer: Reinhard Straubinger." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1032862343/34.
Повний текст джерелаJacksén, Johan. "Improved techniques for CE and MALDI-MS including microfluidic hyphenations foranalysis of biomolecules." Doctoral thesis, KTH, Analytisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-27342.
Повний текст джерелаQC 20101214
Rogers, Kevin Shaun. "Laser desorption/laser ionization mass spectroscopy." Thesis, University of Salford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357037.
Повний текст джерелаClipston, Nigel L. "Laser desorption/laser ionization Time-of-Flight Mass Spectrometry." Thesis, University of Salford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360476.
Повний текст джерелаLu, Tian. "Nanomaterials For Liquid Chromatography and Laser Desorption/Ionization MassSpectrometry." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1376981440.
Повний текст джерелаWen, Xiujuan. "Small Molecule Matrix-free Laser Desorption/ionization Mass Spectrometry." Thesis, The University of Arizona, 2006. http://hdl.handle.net/10150/193332.
Повний текст джерелаPeng, Ivory Xingyu. "Electrospray-assisted laser desorption ionization mass spectrometry for proteomic studies." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1997571271&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Повний текст джерелаBerhane, Beniam T. "Rapid Characterization of Posttranscriptional Modifications in RNA Using Matrix Assisted Laser Desorption Ionization Mass Spectrometry and Matrix Assisted Laser Desorption Ionization Post Source Decay Mass Spectrometry." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1052319621.
Повний текст джерелаMiao, Zhixin. "Development and Applications of Liquid Sample Desorption Electrospray Ionization Mass Spectrometry (DESI-MS)." Ohio University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1347559532.
Повний текст джерелаSproch, Norman K. "PDI-PIXE-MS: Particle Desorption Ionization Particle-Induced X-Ray Emission Mass Spectrometry." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194827.
Повний текст джерелаOsterhage, Katharina Johanna. "Die Zuverlässigkeit von MALDO-TOF MS (Matrix Assisted Laser Desorption." Köln Deutsche Zentralbibliothek für Medizin, 2010. http://d-nb.info/1000932451/34.
Повний текст джерелаDubois, Frédéric Dubois Frédéric. "Ion formation and detection in matrix-assisted laser desorption/ionization mass spectrometry /." [S.l.] : [s.n.], 1999. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13255.
Повний текст джерелаDai, Yuqin. "Development of matrix-assisted laser desorption ionization mass spectrometry for biopolymer analysis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0003/NQ39519.pdf.
Повний текст джерелаShariatgorji, Mohammadreza. "Novel clean-up, concentration and laser desorption/ionization strategies for mass spectrometry /." Stockholm : Department of Analytical Chemistry, Stockholm University, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-32236.
Повний текст джерелаAt the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 3: In Press. Härtill 7 uppsatser.
Dashtiev, Maxim. "Fluorescence spectroscopy of trapped molecular ions produced with matrix-assisted laser desorption/ionization /." Zürich : ETH, 2006. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=16949.
Повний текст джерелаZhang, Hui. "Developments and applications of electrophoresis and small molecule laser desorption ionization mass spectrometry." [Ames, Iowa : Iowa State University], 2007.
Знайти повний текст джерелаAkinapalli, Srikanth. "MICROFLUIDIC DYNAMIC ISOELECTRIC FOCUSING COUPLED TO MATRIX ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY." OpenSIUC, 2016. https://opensiuc.lib.siu.edu/dissertations/1289.
Повний текст джерелаXiang, Fan. "Improvement and investigation of sample preparation for matrix-assisted laser desorption/ionization of proteins." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq25780.pdf.
Повний текст джерелаWang, Jian. "Analyses of food and feed compounds using matrix-assisted laser desorption/ionization mass spectrometry." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0013/NQ59690.pdf.
Повний текст джерелаLiu, Qiang. "Fundamental Study and Method Development for Surface-based Laser Desorption Ionization Imaging Mass Spectrometry." NCSU, 2009. http://www.lib.ncsu.edu/theses/available/etd-02262009-143514/.
Повний текст джерелаBusse, Frederik [Verfasser], and R. J. Dwayne [Akademischer Betreuer] Miller. "Mechanisms of Picosecond Infrared Laser Desorption Ionization / Frederik Busse ; Betreuer: R. J. Dwayne Miller." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://d-nb.info/1192912977/34.
Повний текст джерелаKöchling, Heinrich J. (Heinrich Josef) 1962. "Advancements in matrix-assisted laser desorption ionization mass spectrometry of peptides, proteins and polymers." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/10020.
Повний текст джерелаMowat, Ian A. "Synthetic polymer analysis using matrix assisted laser desorption/ionization time-of-flight mass spectrometry." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/12128.
Повний текст джерелаMazarin, Michaël. "L'ionisation MALDI [Matrix assisted laser desorption/ionization] de polymères synthétiques en spectrométrie de masse." Aix-Marseille 1, 2008. http://theses.univ-amu.fr.lama.univ-amu.fr/2008AIX11034.pdf.
Повний текст джерелаMatrix assisted laser desorption/ionization (MALDI) mass spectrometry is a key technique for synthetic polymer structural characterization. Nevertheless, because fundamental process of MALDI is still not fully understood, no standard protocol is available and experimental conditions are empirically optimized. The aim of this PhD work is to combine mass spectrometric techniques with nuclear magnetic resonance (NMR) spectroscopies to develop rationalized MALDI methodologies for structural studies of synthetic polymers. A first approach consists of using diffusion NMR for a rapid evaluation of polymer average mass, to be further used as a guideline in MALDI sample preparation and spectral data interpretation. A second axis deals with fragile end-groups of macromolecules synthesized via controlled radical polymerization reactions. Combining collision-induced dissociation of electrosprayed oligomers with liquid state NMR and theoretical calculations allowed the elucidation of mechanisms involved in the bond cleavage which is observed to occur within such end-groups during the MALDI process. This study shows that protonation of the fragile termination is the main way to allow intact oligomer ions to be produced. A solvent-free MALDI sample preparation was thus developed to promote macromolecule protonation but its efficiency was shown to be limited to the case of small polymers. Finally, the potential of solid state NMR to characterize the microstructure of MALDI sample was evaluated
Garrett, Timothy J. "Imaging small molecules in tissue by matrix-assisted laser desorption/ionization tandem mass spectrometry." [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0013807.
Повний текст джерелаPriyasantha, Kandalama KD. "DEVELOPMENT OF A NOVEL MATRIX ASSISTED LASER DESORPTION / IONIZATION (MALDI) BASED PEPTIDE QUANTITATION APPROACH." OpenSIUC, 2015. https://opensiuc.lib.siu.edu/dissertations/989.
Повний текст джерелаAstorga-Wells, Juan. "Microfluidic electrocapture technology in protein and peptide analysis /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-965-x/.
Повний текст джерелаErb, William Joseph Owens Kevin G. "Exploration of the fundamentals of matrix assisted laser desorption/ionization time-of- flight mass spectrometry /." Philadelphia, Pa. : Drexel University, 2007. http://hdl.handle.net/1860/1765.
Повний текст джерелаTang, Ho-wai, and 鄧浩維. "Studies on surface-assisted laser desorption/ionization and its analytical application in imaging mass spectrometry." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47145559.
Повний текст джерелаpublished_or_final_version
Chemistry
Doctoral
Doctor of Philosophy
Smith, Donna M. "Matrix Assisted Laser Desorption Ionization Quadrupole Time-of-Flight Mass Spectrometry of Poly(2-Vinylpyridine)." University of Akron / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=akron1110337309.
Повний текст джерелаFiorentino, Michael Armond. "Immediate observation of matrix assisted laser desorption ionization products in a Fourier transform mass spectrometer /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004264.
Повний текст джерела