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Статті в журналах з теми "Laser blood flow meter"

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Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 травня 2022

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1

Ono, Ichiro, Takehiko Ohura, Arihei Yamamoto, Masahiko Murazumi, Hitoshi Fujii, and Toshimitu Asakura. "Evaluation of blood flow of flap using laser speckle flow meter." JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE 8, no. 3 (1987): 253–54. http://dx.doi.org/10.2530/jslsm1980.8.3_253.

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2

MURAYAMA, Mitsuo, Tsutomu MIURA, and Hideo BANDO. "A laser flow meter method for evaluating the peripheral blood flow in mice." Folia Pharmacologica Japonica 108, no. 4 (1996): 203–16. http://dx.doi.org/10.1254/fpj.108.203.

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3

A., Nikhil, K. Sujatha, and Ashlesha Kulkarni. "Laser Doppler Flow Meter: A New Approach for Calculation of Human Blood Flow Rate." International Journal of Computer Applications 127, no. 17 (October 15, 2015): 35–38. http://dx.doi.org/10.5120/ijca2015906721.

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4

Furuta, Toshiaki, Michihiko Sone, Yasushi Fujimoto, Shunjiro Yagi, Makoto Sugiura, Yuzuru Kamei, Hitoshi Fujii, and Tsutomu Nakashima. "Free Flap Blood Flow Evaluated Using Two-Dimensional Laser Speckle Flowgraphy." International Journal of Otolaryngology 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/297251.

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Анотація:

Objective. We investigated the efficiency of laser speckle flowgraphy for evaluating blood flow in free flaps used for plastic surgery.Methods. We measured blood flow using a visual laser meter capable of providing two-dimensional color graphic representations of flow distribution for a given area using a dynamic laser speckle effect. Using laser speckle flowgraphy, we examined the blood flow of 20 free flaps applied following the excision of head and neck tumors.Results. After anastomosis of the feeding and draining blood vessels and sewing the flap, musculocutaneous (MC) flaps showed significantly lower blood flow than jejunal or omental flaps (P<.05). The ratio of blood flow decrease from the edge to the center was significantly greater in MC flaps than in jejunal or omental flaps (P<.001).Conclusion. Laser speckle flowgraphy is useful for the perioperative measurement of blood flow in free flaps used in plastic surgery. This method is a highly useful, practical, and reliable tool for assessing cutaneous blood flow and is expected to be applicable to several clinical fields.

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5

YAMAGUCHI, MIKIO, KUNIHARU AGAWA, HIROYUKI KANETAKE, YASUO KOIKE, and KENZI KASHIMA. "Measurement of blood flow in human tympanic membrane with spectrophotometory and laser speckle flow meter." Nippon Jibiinkoka Gakkai Kaiho 93, no. 9 (1990): 1354–62. http://dx.doi.org/10.3950/jibiinkoka.93.1354.

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6

Pershing, Lynn K., Sue Huether, Rebecca L. Conklin, and Gerald G. Krueger. "Cutaneous Blood Flow and Percutaneous Absorption: A Quantitative Analysis Using a Laser Doppler Velocimeter and a Blood Flow Meter." Journal of Investigative Dermatology 92, no. 3 (March 1989): 355–59. http://dx.doi.org/10.1111/1523-1747.ep12277181.

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7

Meyer, Fernando, Denise Sbrissia e. Silva, Giovana Marina Bombonatto, Juliana Navarro Lizana, Luiz Felipe Dziedricki, and Michele Lonardoni Krieger. "Histological analysis and the blood flux in kidneys submitted to different periods of ischemia/reperfusion." Acta Cirurgica Brasileira 26, no. 6 (December 2011): 451–55. http://dx.doi.org/10.1590/s0102-86502011000600008.

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PURPOSE: Evaluate the renal blood flow by using a laser flow meter, Laserflow Vasamedics®, after the ischemia/reperfusion in two different times of the arterial renal vessel clamping. METHODS: The renal blood flow was evaluated by using a laser flow meter after two different times of ischemia/reperfusion procedure, 30 and 60 minutes. It was used 20 Wistar male rats, divided in two groups of 10 rats: Group A (30 minutes of ischemia on the left kidney, with later analysis of the blood flow in 1, 5 and 20, after the renal reperfusion start) and Group B (60 minutes of ischemia on the left kidney, with later analysis of the blood flow in 1, 5 and 20 minutes, after the renal reperfusion start). RESULTS: In the first minute, there were not significant differences between the two groups (p=0.789). In the 5th minute there were not significant differences also, but there was a tendency (p=0.068). In the 20th minute, there was a significant difference between the 2 groups (p=0.022). When the means are observed, it is possible to notice that Group A has a larger flux than Group B. CONCLUSION: The kidneys submitted to 30' of ischemia/reperfusion are subject to a larger restitution of the blood flow in comparison to the Group which had a longer time.

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8

Nishihara, K., W. Iwasaki, M. Nakamura, E. Higurashi, T. Soh, T. Itoh, H. Okada, R. Maeda, and R. Sawada. "Development of a Wireless Sensor for the Measurement of Chicken Blood Flow Using the Laser Doppler Blood Flow Meter Technique." IEEE Transactions on Biomedical Engineering 60, no. 6 (June 2013): 1645–53. http://dx.doi.org/10.1109/tbme.2013.2241062.

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9

UMEDA, Yuji. "Measurement of blood flow of the peripheral nerve using a laser doppler flow meter-A canine experiment." Juntendo Medical Journal 43, no. 4 (1998): 576–85. http://dx.doi.org/10.14789/pjmj.43.576.

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10

Kijsamanmith, Kanittha, Noppakun Vongsavan, and Bruce Matthews. "Pulpal blood flow recorded from exposed dentine with a laser Doppler flow meter using red or infrared light." Archives of Oral Biology 87 (March 2018): 163–67. http://dx.doi.org/10.1016/j.archoralbio.2017.12.009.

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11

Roman, R. J., and C. Smits. "Laser-Doppler determination of papillary blood flow in young and adult rats." American Journal of Physiology-Renal Physiology 251, no. 1 (July 1, 1986): F115—F124. http://dx.doi.org/10.1152/ajprenal.1986.251.1.f115.

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Renal hemodynamics and renal blood flow autoregulatory ability differ in young (body wt 100 g) and adult (body wt 300 g) rats. Possible age-dependent changes in inner medullary hemodynamics have not been examined because it has not been possible to expose the papilla of adult rats for direct study of the vasa recta circulation. This study presents a technique for exposure of the papilla in any size rat. Seven days before an acute experiment, a small amount of cortical tissue overlying the papilla on the dorsal surface of the kidney was removed. The creation of this papillary window allowed for exposure of the papilla in adult rats after removal of the ureter. Using this preparation, we compared papillary blood flow in young and adult rats using a Periflux differential laser-Doppler flowmeter (Perimed, Stockholm, Sweden). The meter was calibrated by comparing the signal obtained from the papilla of 28 rats with papillary flow measured from the accumulation of 51Cr-labeled erythrocytes in the papilla. The laser-Doppler flow signal was linearly related and highly correlated (r = 0.92) to the red cell flow into the papilla. Comparisons of laser-Doppler flow signals obtained from the papilla of young and adult animals indicated that papillary blood flow was approximately 2-fold greater in the adult rats than in the young animals. This finding was associated with an enhanced maximal urine concentrating ability found in the younger rats. These studies demonstrate the utility of the laser-Doppler flowmeter for the assessment of papillary blood flow and suggest that inner medullary hemodynamics differ in young and adult rats.

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12

Kuchiwaki, H., S. Inao, K. Sugita, and S. Kashima. "AN EXPERIMENTAL STUDY OF CEREBRAL BLOOD FLOW AND SOME CONSIDERATIONS ON OBTAINING RELIABLE DATA USING A LASER FLOW METER." LASER THERAPY 3, no. 2 (1991): 51–57. http://dx.doi.org/10.5978/islsm.91-or-06.

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13

Kijsamanmith, Kanittha, Siriporn Timpawat, Noppakun Vongsavan, and Bruce Matthews. "Pulpal blood flow recorded from human premolar teeth with a laser Doppler flow meter using either red or infrared light." Archives of Oral Biology 56, no. 7 (July 2011): 629–33. http://dx.doi.org/10.1016/j.archoralbio.2010.12.003.

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14

UEDA, Joji, Etsuko OHYA, Kozue UDAGAWA, Akiko HARA, Mai FUKUI, Hirokazu YAMAGISHI, Takahiro NAKAZAWA, Takaaki YASUDA, and Keisuke OHSAWA. "Effect of Kampo Medicines on the Peripheral Blood Flow Rate of Betamethason-Induced Oketsu Syndrome Mice by Laser Doppler Flow Meter." YAKUGAKU ZASSHI 124, no. 6 (June 1, 2004): 365–69. http://dx.doi.org/10.1248/yakushi.124.365.

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15

Nogami, H., W. Iwasaki, T. Abe, Y. Kimura, A. Onoe, E. Higurashi, S. Takeuchi, M. Kido, M. Furue, and R. Sawada. "Use of a simple arm-raising test with a portable laser Doppler blood flow meter to detect dehydration." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 225, no. 4 (January 14, 2011): 411–19. http://dx.doi.org/10.1243/09544119jeim727.

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16

Kijsamanmith, Kanittha, Siriporn Timpawat, Noppakun Vongsavan, and Bruce Matthews. "A comparison between red and infrared light for recording pulpal blood flow from human anterior teeth with a laser Doppler flow meter." Archives of Oral Biology 56, no. 6 (June 2011): 614–18. http://dx.doi.org/10.1016/j.archoralbio.2011.02.010.

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17

Vongsavan, N., and B. Matthews. "Some aspects of the use of laser Doppler flow meters for recording tissue blood flow." Experimental Physiology 78, no. 1 (January 1, 1993): 1–14. http://dx.doi.org/10.1113/expphysiol.1993.sp003664.

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18

Wiles, P. G., P. J. Grant, and J. A. Davies. "The differential effect of arginine vasopressin on skin blood flow in man." Clinical Science 71, no. 6 (December 1, 1986): 633–38. http://dx.doi.org/10.1042/cs0710633.

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1. Physiological elevation of plasma vasopressin in man results in a small reduction in skeletal muscle blood flow but the action on skin blood flow has not been reported. 2. We have studied eight male subjects during infusion of arginine vasopressin (AVP) at 2 units/h for 90 min. Plasma levels of AVP, measured by radioimmunoassay, rose to 68.5 (7.0) pg/ml, mean (sem). Forearm and finger blood flow was measured with an electronic plethysmograph, hand interdigital skin-fold blood flow with a laser-Doppler blood flow meter and facial temperature with a thermocouple. 3. All subjects developed marked facial pallor during infusion of AVP, facial temperature falling from 34.2 (0.2) to 32.7 (0.1)°C (P < 0.001) then rising to 33.7 (0.1)°C (P < 0.01) after AVP was stopped. Hand interdigital skin-fold blood flow also fell from 2.6 (0.02) to 2.3 (0.02) V (P < 0.001) and rose sharply to 3.6 (0.2) V (P < 0.001) on stopping the infusion. There were small changes in forearm and finger blood flow: both rose, from 6.3 (0.1) to 6.9 (0.1) (P < 0.001) and 46.1 (1.0) to 54.3 (0.7) ml min−1 100 ml−1 (P < 0.001) respectively. Neither fell when AVP was stopped. Heart rate remained unchanged throughout. 4. These results indicate that high physiological levels of AVP, comparable with those attained during physical stress, produced a fall in blood flow in the face and interdigital skin-fold of the hand consistent with a fall in nutritional blood flow to skin. Blood flow to skeletal muscle, however, remained little changed whereas that through arteriovenous anastomoses in skin of the finger rose. 5. We conclude that AVP has a selective vasoactive effect in skin, constricting nutritional blood vessels and venules while promoting an increase in arteriovenous shunting of blood.

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19

ABE, Yuuichi, Kenkichi OHBA, and Tsutomu TAJIKAWA. "Development of discrimination method of emboli and bubbles in blood flow by combination of Laser Doppler Velocimeter (LDV) and Ultrasound Doppler flow meter (USD)." Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2004.16 (2004): 377–78. http://dx.doi.org/10.1299/jsmebio.2004.16.377.

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20

Tanioka, Hideki, Shigeru Miyagawa, Daisuke Mori, Ken-ichi Watanabe, Takayoshi Ueno, Koichi Toda, Takashi Shibuya, Toru Kuratani, and Yoshiki Sawa. "New cell delivery system CellSaic with adipose-derived stromal cells promotes functional angiogenesis in critical limb ischemia model mice." Journal of Artificial Organs 24, no. 3 (March 3, 2021): 343–50. http://dx.doi.org/10.1007/s10047-021-01254-8.

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AbstractCurrent therapies for patients with critical limb ischemia have not reduced amputation risk owing to poor cell engraftment. The recombinant peptide Cellnest increases the engraftment rate of administered cells by forming a complex with the cells (CellSaic). We hypothesized that CellSaic containing adipose-derived stromal cells (ADSCs) could improve lower limb blood flow better than ADSCs alone, resulting in better transplanted cell engraftment. ADSCs were extracted from 8-week-old C57BL/6N mice. Thirty-two critical limb ischemia model mice were established by ligating femoral arteries. They were divided into CellSaic (n = 11), ADSC (n = 10), saline (n = 9), and Cellnest (n = 9) groups. Blood flow rate (affected side blood flow / healthy side blood flow × 100%) was evaluated using a laser Doppler blood flow meter every week. Mice were euthanized on day 28 for histological evaluation. Compared with the ADSC group (54.5 ± 17.2%), treated side blood flow rate of the CellSaic group (78.0 ± 24.9%) showed significant improvement on day 28 after administration (p < 0.05). CD31 staining showed significantly higher number of capillary vessels in the CellSaic group (53.0 ± 8.9 cells/mm3) than in the ADSC group (43.0 ± 6.8 cells/mm3) (p < 0.05). Fluorescent staining showed significantly higher number of arterioles containing both CD31 and αSMA double-positive cells in the CellSaic group than in the ADSC group (p < 0.05). CellSaic containing ADSCs exhibited superiority to ADSC transplantation alone in promoting functional angiogenesis, suggesting its potential in improving clinical outcomes of angiogenic therapy for ischemic limbs.

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21

Dykes, P. J., D. R. Black, M. York, A. D. Dickens, and R. Marks. "A stepwise procedure for evaluating irritant materials in normal volunteer subjects." Human & Experimental Toxicology 14, no. 2 (February 1995): 204–11. http://dx.doi.org/10.1177/096032719501400209.

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1 The cutaneous response to a known irritant has been assessed in human volunteer subjects using both clini cal scoring and two non-invasive instrumental meth ods ; erythema measurement using an erythema meter and capillary blood flow using a laser Doppler device. 2 Aqueous solutions (0.5% and 1%) of sodium hydroxide were applied to back skin for 3, 15 and 60 min with assessments immediately after removal and at 1, 24 and 48 hours. 3 Increased erythema was seen with increasing duration of exposure and an increase was also seen at 1 h, 24 h and 48 h after removal of the patch. The results obtained with the erythema meter paralleled the clini cal erythema scores. However, the laser Doppler device showed the greatest changes immediately after removal of the patch with subsequent readings show ing a gradual decrease. 4 Statistical analysis of the data has been carried out to determine the accuracy and precision of the assess ment procedures and to determine the minimum test panel size for detecting irritant reactions. 5 Comparison between back and forearm skin indicated a greater sensitivity to sodium hydroxide on the back. 6 The results of this study define an ethical approach to testing irritant materials in human subjects and pro vide the basis for the development of a classification system for cutaneous irritants.

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22

Ze, Wang, Tan Wen-sheng, Ye-Xia, Zhang Ming, Li Xiao-ping, Qiu Jian-guo, and Yang Xiao-Hong. "Preparation of anticoagulant PyC biomaterials with super-hydrophobic surface." Journal of Applied Biomaterials & Functional Materials 16, no. 1_suppl (January 2018): 125–31. http://dx.doi.org/10.1177/2280800017753315.

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Introduction: Pyrolytic carbon (PyC) is a kind of biomaterial which is chemically inert and has excellent biocompatibility. In order to obtain a super-hydrophobic PyC surface to improve anticoagulation and inhibit thrombus, this study prepares grating pair structure, microhole array structure, helix structure on PyC surface by nanoseconds laser etching. Methods: Rod-like ZnO film and ball-like ZnO film are prepared on the PyC surface by the hydrothermal method; polyvinyl pyrrolidone (PVP) nanofiber film and PVP/TiO2 complex nanofiber film are prepared on the PyC surface by the electrospinning method; the PyC surface is silanized. Finally, surface microstructure and surface energy are characterized by scanning electron microscopy and contact angle meter (OCA20, German DataPhysics Co.). Results: The periodical microstructures are formed respectively by nanoseconds laser etching. The surface roughness is increased by the hydrothermal and electrospinning method. Conclusions: Through infiltration experiment on rough and smooth PyC surfaces, rough PyC surface with microstructure is super-hydrophobic and has greater than 150° contact angle, which decreases blood flow resistance and inhibits thrombus.

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23

Sato, Toshiya, and Hisayoshi Ishii. "Differences in control of parasympathetic vasodilation between submandibular and sublingual glands in the rat." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 309, no. 11 (December 1, 2015): R1432—R1438. http://dx.doi.org/10.1152/ajpregu.00306.2015.

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We examined blood flow in the submandibular gland (SMGBF) and sublingual gland (SLGBF) during electrical stimulation of the central cut end of the lingual nerve (LN) in the urethane-anesthetized rats using a laser speckle imaging flow meter. LN stimulation elicited intensity- and frequency-dependent SMGBF and SLGBF increases, and the magnitude of the SMGBF increase was higher than that of the SLGBF increase. The increase in both glands was significantly inhibited by intravenous administration of the autonomic cholinergic ganglion blocker hexamethonium. The antimuscarinic agent atropine markedly inhibited the SMGBF increase and partly inhibited the SLGBF increase. The atropine-resistant SLGBF increase was significantly inhibited by infusion of vasoactive intestinal peptide (VIP) receptor antagonist, although administration of VIP receptor antagonist alone had no effect. The recovery time to the basal blood flow level was shorter after LN stimulation than after administration of VIP. However, the recovery time after LN stimulation was significantly delayed by administration of atropine in a dose-dependent manner to the same level as after administration of VIP. Our results indicate that 1) LN stimulation elicits both a parasympathetic SMGBF increase mainly evoked by cholinergic fibers and a parasympathetic SLGBF increase evoked by cholinergic and noncholinergic fibers, and 2) VIP-ergic mechanisms are involved in the noncholinergic SLGBF increase and are activated when muscarinic mechanisms are deactivated.

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24

Shiokawa, Yayoi, Shino Miyauchi-Wakuda, Satomi Kagota, Kana Maruyama-Fumoto, Shizuo Yamada, and Kazumasa Shinozuka. "Acanthopanax senticosus Induces Vasorelaxation via Endothelial Nitric Oxide-Dependent and -Independent Pathways." Planta Medica 85, no. 13 (July 23, 2019): 1080–87. http://dx.doi.org/10.1055/a-0978-5214.

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AbstractAlthough Acanthopanax senticosus root extract (ASRE), a functional food used in Japan, improves peripheral blood circulation and exerts vasorelaxant effects in rats under healthy conditions, the underlying mechanisms currently remain unclear. Therefore, we investigated the mechanisms responsible for ASRE-induced relaxation in isolated thoracic aortas using organ bath techniques and examined whether ASRE affects systemic and peripheral circulation using a photoplethysmographic tail-cuff system and noncontact laser tissue blood flow meter in Wistar rats. Similar to acetylcholine (ACh), ASRE induced dose-dependent relaxation in aortas pre-contracted with phenylephrine; however, in contrast to ACh, ASRE-induced relaxation was partially inhibited by treatments with antagonists of nitric oxide (NO) synthase and soluble guanylyl cyclase as well as by endothelium removal. Contractile responses to phenylephrine or potassium chloride were observed in the presence of ASRE. The oral administration of ASRE (900 mg/kg/d for 1 wk) decreased systolic blood pressure in rats 3 h after the treatment and did not affect heart rate, tail blood flow, mass, or velocity; this decreasing effect was not observed on day 2. A 1-wk treatment with ASRE did not affect vasorelaxation in response to ASRE. These results demonstrate that ASRE induces vasorelaxation via endothelial NO production and an NO-independent pathway in rats. Based on these findings, positive impacts of ASRE on blood pressure and peripheral blood circulation cannot be expected under healthy conditions as the systemic effects of ASRE are temporary. Instead, caution is needed to prevent the occurrence of side effects (i.e., orthostatic dizziness) at the beginning of ASRE dosing.

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25

Iwasaki, Wataru, Hirofumi Nogami, Hiroki Ito, Takeshi Gotanda, Yao Peng, Satoshi Takeuchi, Masutaka Furue, Eiji Higurashi, and Renshi Sawada. "Useful method to monitor the physiological effects of alcohol ingestion by combination of micro-integrated laser Doppler blood flow meter and arm-raising test." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 226, no. 10 (July 16, 2012): 759–65. http://dx.doi.org/10.1177/0954411912452974.

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26

Matsui, T., S. Suzuki, K. Ujikawa, T. Usui, S. Gotoh, M. Sugamata, Z. Badarch, and S. Abe. "Development of a non-contact screening system for rapid medical inspection at a quarantine depot using a laser Doppler blood-flow meter, microwave radar and infrared thermography." Journal of Medical Engineering & Technology 33, no. 5 (January 2009): 403–9. http://dx.doi.org/10.1080/03091900902821151.

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27

Rådegran, Göran. "Limb and skeletal muscle blood flow measurements at rest and during exercise in human subjects." Proceedings of the Nutrition Society 58, no. 4 (November 1999): 887–98. http://dx.doi.org/10.1017/s0029665199001196.

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Анотація:

The aim of the present review is to present techniques used for measuring blood flow in human subjects and advice as to when they may be applicable. Since blood flow is required to estimate substrate fluxes, energy turnover and metabolic rate of skeletal muscle, accurate measurements of blood flow are of extreme importance. Several techniques have therefore been developed to enable estimates to be made of the arterial inflow to, venous outflow from, or local blood flow within the muscle. Regional measurements have been performed using electromagnetic flow meters, plethysmography, indicator methods (e.g. thermodilution and indo-cyanine green dye infusion), ultrasound Doppler, and magnetic resonance velocity imaging. Local estimates have been made using 133Xe clearance, microdialysis, near i.r. spectroscopy, positron emission tomography and laser Doppler. In principle, the aim of the study, the type of interventions and the limitations of each technique determine which method may be most appropriate. Ultrasound Doppler and continuous indo-cyanine green dye infusion gives the most accurate limb blood flow measurements at rest. Moreover, the ultrasound Doppler is unique, as it does not demand a steady-state, and because its high temporal resolution allows detection of normal physiological variations as well as continuous measurements during transitional states such as at onset of and in recovery from exercise. During steady-state exercise thermodilution can be used in addition to indo-cyanine green dye infusion and ultrasound Doppler, where the latter is restricted to exercise modes with a fixed vessel position. Magnetic resonance velocity imaging may in addition be used to determine blood flow within deep single vessels. Positron emission tomography seems to be the most promising tool for local skeletal muscle blood-flow measurements in relation to metabolic activity, although the mode and intensity of exercise will be restricted by the apparatus design.

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28

Vongsavan, N., and B. Matthews. "The Vascularity of Dental Pulp in Cats." Journal of Dental Research 71, no. 12 (December 1992): 1913–15. http://dx.doi.org/10.1177/00220345920710121101.

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The fraction of the volume of the coronal pulp of cat canines that is occupied by blood vessels was estimated by measurement of the cross-sectional areas of all the vessels in a complete transverse section of the pulp from each of four teeth. The sections were taken 0.5 mm from the pulp comu. Overall, 14.4% of the area of the pulp was occupied by vessels. In the core of the pulp, the average value was 42.9%, and superficially, near the odontoblast layer, it was between 5 and 10%. The average capillary density was 1402 /mm2, which is higher than in most other tissues. Laser Doppler flow meters can be used for recording blood flow from the coronal pulp of intact teeth, but these instruments are linear only if the moving blood cells occupy no more than 1% of the tissue volume. The present results suggest that this figure is exceeded in pulp.

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29

Matsui, T., S. Suzuki, K. Ujikawa, T. Usui, S. Gotoh, M. Sugamata, and S. Abe. "RETRACTED: The development of a non-contact screening system for rapid medical inspection at a quarantine depot using a laser Doppler blood-flow meter, microwave radar and infrared thermography." Journal of Medical Engineering & Technology 33, no. 6 (January 2009): 481–87. http://dx.doi.org/10.1080/03091900902952675.

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30

Lin, Qing, Xiaoju Zou, Li Fang, and William D. Willis. "Sympathetic Modulation of Acute Cutaneous Flare Induced by Intradermal Injection of Capsaicin in Anesthetized Rats." Journal of Neurophysiology 89, no. 2 (February 1, 2003): 853–61. http://dx.doi.org/10.1152/jn.00568.2002.

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Much of the acute cutaneous neurogenic inflammation after intradermal injection of capsaicin (CAP) in rats is mediated by dorsal root reflexes (DRRs), which cause the release of inflammatory agents from primary afferent terminals. Sympathetic efferents modulate neurogenic inflammation by interaction with primary afferent terminals. In this study, we examined if DRR-mediated flare after CAP injection is subject to sympathetic modulation. Changes in cutaneous blood flow on the plantar surface of the foot were measured using a laser Doppler flow meter. After CAP injection, cutaneous flare spread more than 20 mm away from the site of CAP injection. However, this CAP-induced flare was significantly reduced after surgical sympathectomy. Decentralization of postganglionic neurons did not affect the flare induced by CAP injection. If the foot of sympathectomized rats was pretreated with an α1-adrenoceptor agonist (phenylephrine) by intra-arterial injection, the spread of flare induced by CAP injection could be restored. However, if the spinal cord was pretreated with a GABAA receptor antagonist, bicuculline, to prevent DRRs, phenylephrine no longer restored the CAP-evoked flare. An α2-adrenoceptor agonist (UK14,304) did not affect the CAP-evoked flare in sympathectomized rats. In sympathetically intact rats, blockade of peripheral α1-adrenoceptors with terazosin profoundly reduced the flare induced by CAP injection, whereas blockade of peripheral α2-adrenoceptors by yohimbine did not obviously affect the flare. Therefore the pathogenesis of acute neurogenic inflammation in the intradermal CAP injection model depends in part on intact sympathetic efferents and α1-adrenoceptors. Peripheral α1-adrenoceptors thus modulate the ability of capsaicin sensitive afferents to evoke the release of inflammatory agents from primary afferents by DRRs.

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31

Glukhovets, D. I. "STUDY OF BIO-OPTICAL CHARACTERISTICS OF THE BARENTS AND NORWEGIAN SEAS SURFACE LAYER WATERS IN SUMMER 2017." XXII workshop of the Council of nonlinear dynamics of the Russian Academy of Sciences 47, no. 1 (April 30, 2019): 145–60. http://dx.doi.org/10.29006/1564-2291.jor-2019.47(1).44.

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A study of the surface layer bio-optical properties of the Barents and Norwegian Seas in the summer of 2017 is carried out. Ship data were obtained during the 68th cruise of the R/V ‘Akademik Mstislav Keldysh’ (June-August 2017). Using a flow-through system, the fluorescence intensities of chlorophyll ‘a’ and dissolved organic matter as well as the salinity and temperature of the water surface layer along the ship’s route were continuously recorded. Seawater samples were taken for spectral fluorescence and absorbance measurements performed with a laser spectrometer and an integrating cavity absorption meter. The results are compared with the data of direct determinations of the chlorophyll concentration. Frequent continuous cloudiness prevented the use of ocean color data for the Norwegian Sea. In the coccolithophore bloom area in the Barents Sea, the results of shipboard measurements are compared with the data of OLCI satellite scanner. In this area, standard OLCI algorithms overestimate chlorophyll concentration, while the regression algorithm works better than based on neural networks. Comparison of the fluorescence and absorption spectra has shown the possibility of carrying out a rapid assessment of the chlorophyll concentration using optical methods. The change in the coefficients of the regression equations of chlorophyll fluorescence intensity and its concentration, determined by direct methods for different regions, is shown.

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32

Ohno, Tsuyoshi, Takashi Mine, Hiroki Yoshioka, Mikiko Kosaka, Sadayuki Matsuda, Maiko de Kerckhove, Charles de Kerckhove, et al. "Relationship of peripheral neuropathy grades with increase of skin perfusion by compression therapy for breast cancer patients." Journal of Clinical Oncology 32, no. 31_suppl (November 1, 2014): 182. http://dx.doi.org/10.1200/jco.2014.32.31_suppl.182.

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182 Background: Chemotherapy-induced peripheral neuropathy (CIPN) has become a substantial problem because of specific cytotoxic agents such as nab-paclitaxel, oxaliplatin, and eribulin. In addressing CIPN-related side effects caused by nab-PTX, we previously reported better CTCAE v4.0 grades and superior nab-PTX dose maintenance in breast cancer treatment adopting our 3S approach. Our 3S approach combines compression therapy (stockings and sleeves applied 24 hours from the beginning of nab-PTX administration) with medication therapy (selected prophylactic medications goshajinkigan, lafutidine, and mecobalamin applied over the course of treatment). In revisiting how stocking use restored skin perfusion levels decreased by nab-PTX chemotherapy, we examined whether the skin perfusion increases differ by CIPN grade. Methods: Using a laser Doppler blood flow meter with integrated probe (NL-101 Nahri Nexis Japan), we measured the skin perfusion of the lower limbs before and after stocking use across four groups: three groups of 3S prophylactics-treated nab-PTX patients divided by CIPN grade (Grade 0 [G0, n=12], Grade 1 [G1, n=20], Grades 2 and 3 combined [G2+3, n=12]), and one control group of healthy volunteers (GH, n=50). Results: In the control group (GH), the mean increase in skin perfusion level (mL/min/100g) after wearing stockings was 0.90 (SD= 3.36). For the 3S prophylactic treatment patients, the mean increase was 4.25 (4.98) in the G0 group, 2.11 (4.93) in the G1 group, and 2.69 (2.53) in the G2+3 group. ANOVA analysis indicated a significant difference in skin perfusion increase among the groups (p=0.0493). Analysis between the groups indicated significance in the G0 group increase over the control group increase (p=0.0255). Conclusions: CIPN was previously shown to decrease skin perfusion; in the current study skin perfusion responsiveness to stockings differed significantly between chemotherapy patients and healthy volunteers. Restorative skin perfusion increase is potentially related with alleviating CIPN grade, for which further evaluation is needed.

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Shah, Payal, Adam Bush, Silvie Suriany, Honglei Liu, Henry J. Forman, Patjanaporn Chalacheva, Wanwara Thuptimdang, et al. "Hemolysis and Tricuspid Regurgitation Jet Velocity Predict Mortality in Patients with Sickle Cell Disease." Blood 132, Supplement 1 (November 29, 2018): 1086. http://dx.doi.org/10.1182/blood-2018-99-119587.

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Abstract Introduction Over the last two decades, sickle cell disease has become a model of diffuse endotheliopathy. In 2004, Gladwin and colleagues demonstrated that elevated tricuspid regurgitation jet velocity (TRJ) was an independent predictor of mortality and that chronic red blood cell hemolysis underlies pulmonary vascular disease (Gladwin et. al. NEJM, PMID:14985486). Belhassen and colleagues demonstrated that flow-mediated dilation of the brachial artery (FMD) was decreased in patients with sickle cell disease, specifically shear-mediated vasodilation (Belhassen et. al. Blood, PMID:11238095). Our group demonstrated that plasma free hemoglobin links decreased FMD and elevated TRJ in patients with sickle cell disease and that chronic transfusion therapy improves FMD (Detterich et. al. Blood, PMID:26036801). We aimed to determine whether markers of vascular function predict the risk of mortality in a cohort of patients with sickle cell disease. Methods This was a single center, prospective cohort study of non-transfused and chronically transfused sickle cell anemia patients at Children's Hospital of Los Angeles between 2009 and 2012 aiming to assess vascular function in sickle cell disease. This study was approved by the Children's Hospital Los Angeles Institutional Review Board. We used FMD, a test of shear-mediated endothelial nitric oxide release as the model for vascular function. We simultaneously measured the regional hemoglobin oxygen saturation in the hand using near infrared spectroscopy (NIRS). We also measured microcirculatory perfusion using laser doppler flowmetry (LDF) over the skin of the nailbed. Echocardiography was performed on the same day to assess tricuspid regurgitation jet velocity and cardiac function. Markers of inflammation, cell count and hemolysis were also measured on the day of the study. We prospectively followed them until 2018 to assess our primary outcome, survival. All of the measurements were made pre-transfusion for chronically transfused subjects. Kaplan Meier and Cox-Proportional Hazards multivariate model was used to determine independent predictors of survival. All statistics were performed using Stata/IC version 14.0. Results We enrolled 26 chronically transfused patients with SCD and 63 non-transfused SCD patients in a study assessing the effects of hemolysis on endothelial function. Overall mortality in our cohort was 20% with a median follow up time of 7.8 years (7.1-8.3 IQR). Median age was 24 years at the time of study (17-36 IQR). Median age at the time of death was 36 years(28-51 IQR) and at the last follow up for the alive patients was 30 years (25-41 IQR), p=0.01. In the patients who died, they had higher TRJ (median 270 vs 235, p=0.03) and had elevated plasma Hgb, median 26 vs 14, p=0.01. FMD, regional oxygen saturation and microcirculatory perfusion were not different between alive and deceased patients. There was no difference for inflammatory markers (white blood cell count, platelet count, high sensitivity C-reactive protein), hemoglobin S%/transfusion, or anemia (hemoglobin/hematocrit/reticulocytes) between alive or deceased patients. By Kaplan Meier analysis individual factors associated with mortality were TRJ>250 (p=0.04) and age>21 (p=0.02) (Fig 1 and Fig 2). By Cox-Proportional Hazards Model, both TR jet velocity and plasma hemoglobin remain significant after correcting for age (Table 1). Conclusions In our cohort, there are multiple abnormal markers of vascular function and elevated markers of hemolysis; however, the strongest predictors of mortality were age, plasma free hemoglobin and tricuspid regurgitation jet velocity. These findings support the association between hemolysis, pulmonary vascular disease and mortality, a controversial topic in sickle cell disease. Disclosures Coates: Vifor Pharma: Consultancy; Sangamo: Consultancy, Honoraria; Celgene Corp.: Consultancy; ApoPharma: Consultancy, Honoraria.

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Mohan, Junette, Janice M. Marshall, H. L. Reid, P. W. Thomas, I. Hambleton, and G. R. Serjeant. "Peripheral Vascular Response to Mild Indirect Cooling in Patients with Homozygous Sickle Cell (SS) Disease and the Frequency of Painful Crisis." Clinical Science 94, no. 2 (February 1, 1998): 111–20. http://dx.doi.org/10.1042/cs0940111.

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1. In homozygous sickle cell (SS) disease, skin cooling is a common precipitating factor of the painful crisis which is associated with avascular necrosis of active bone marrow. Since skin cooling does not directly induce sickling, we have investigated the nature of the reflex vascular responses to mild cooling in SS patients in a steady state of the disease and compared them with their history of painful crises. 2. Experiments were performed in Jamaica on 60 male SS patients and 30 matched control subjects with normal haemoglobin (AA) genotype. Forearm blood flow (FBF) was measured by venous occlusion plethysmography and mean arterial pressure (MAP) by a Finapres device: forearm vascular resistance (FVR) was calculated as MAP/FBF. Cutaneous erythrocyte flux in forearm and hand was monitored by a laser Doppler meter. The contralateral hand was immersed in cool water at 16°C for 2 min, 6 times, at random intervals of 0.5–3 min. 3. The first cool immersion evoked an increase in MAP, cutaneous vasoconstriction and a net increase in FVR in both AA and SS subjects. However, the direction of change in FVR varied between individuals such that 18 AA subjects showed an increase in FVR (constrictor group) while 12 showed a decrease in FVR, indicating vasodilatation in forearm muscle (dilator group). In contrast, 50 SS subjects showed an increase in FVR and only 10 showed a decrease in FVR. The proportion of subjects who showed net vasoconstriction was significantly greater in the SS than in the AA group (83% versus 60%, P = 0.03, χ2 test). 4. By the sixth cool stimulus, the ‘dilator’ group of AA subjects showed no change in FVR while the ‘dilator’ group of SS patients showed an increase in FVR. We suggest that forearm muscle vasodilatation was the characteristic component of the alerting/defence response to novel or noxious stimuli which habituates on repetition. 5. In the whole group of SS patients, baseline values of cutaneous vascular resistance and FVR increased between stimuli, indicating persistent vasoconstriction, and the sixth cool stimulus still evoked cutaneous vasoconstriction and a net increase in FVR. In contrast, AA subjects showed an increase in baseline FVR between stimuli, but the sixth cool stimulus had no significant effect on cutaneous vascular resistances, or FVR. 6. In SS patients there were no associations between the direction of change in FVR evoked by the first cool stimulus and forearm circumference or skinfold thickness, concentrations of haemoglobin or fetal haemoglobin. However, the frequency of painful crises was significantly greater in the ‘constrictor’ group than in the ‘dilator’ group (0.36 versus 0.12/year, P = 0.04, Mann-Whitney test). 7. These results indicate that the primary reflex vasoconstrictor response evoked by mild cooling is stronger and more persistent in SS patients than in AA subjects and is particularly strong in SS patients who are most prone to painful crises. The results are consistent with the hypothesis that skin cooling may precipitate the painful crisis by causing reflex vasoconstriction in muscle, and possibly in bone marrow, so diverting blood flow away from the active marrow.

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35

Kosaka, Ryo, Hiromasa Nishida, Osamu Maruyama, Takashi Yamane, Tatsuya Hidaka, and Takeshi Okubo. "Development of Mass-Flow Meter for Axial Flow Blood Pump." Journal of Life Support Engineering 19, Supplement (2007): 30. http://dx.doi.org/10.5136/lifesupport.19.supplement_30.

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36

Doten, Gregory P., and Brian P. Brockway. "Blood flow meter apparatus and method of use." Journal of the Acoustical Society of America 115, no. 3 (2004): 961. http://dx.doi.org/10.1121/1.1697790.

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37

Koelink, M. H., F. F. M. de Mul, B. Leerkotte, J. Greve, H. W. Jentink, R. Graaff, A. C. M. Dassel, and J. G. Aarnoudse. "Signal processing for a laser-Doppler blood perfusion meter." Signal Processing 38, no. 2 (July 1994): 239–52. http://dx.doi.org/10.1016/0165-1684(94)90143-0.

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38

Kosaka, Ryo, Osamu Maruyama, Masahiro Nishida, and Takashi Yamane. "Development of Miniaturized Mass Flow Meter for an Axial Flow Blood Pump." Artificial Organs 31, no. 5 (May 2007): 412–19. http://dx.doi.org/10.1111/j.1525-1594.2007.00402.x.

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39

Nakaji, Peter. "Laser Speckle Flow Imaging of Cerebral Blood Flow." World Neurosurgery 82, no. 6 (December 2014): e697-e698. http://dx.doi.org/10.1016/j.wneu.2014.02.009.

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40

Sakamoto, T., N. Kawahara, H. Tanaka, M. Sasaki, T. Aruga, K. Mii, and K. Takakura. "Experimental study of continuous cerebral blood flow monitoring by the temperature-controlled thermoelectrical tissue blood flow meter." Neurosurgical Review 12, S1 (March 1989): 377–81. http://dx.doi.org/10.1007/bf01790677.

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41

Mizutani, Tetsuo, Motoshi Takao, Kouji Onoda, Yoshihiko Katayama, Isao Yada, Hiroshi Yuasa, and Minoru Kusagawa. "Laser Measurement of Myocardial Blood Flow." Journal of Clinical Laser Medicine & Surgery 9, no. 6 (December 1991): 439–43. http://dx.doi.org/10.1089/clm.1991.9.439.

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42

Zhang, Hongwei, Songhua Wu, Jintao Liu, Yuanshuai Zhang, and Xiaomin Chen. "Research on Non-Invasive Laser Doppler Current Measurement for Hydrothermal Vents Flow Rates Profile." EPJ Web of Conferences 237 (2020): 07023. http://dx.doi.org/10.1051/epjconf/202023707023.

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Hydrothermal vents play important roles in the dynamic process of the stratosphere and the circulation of energy materials. Nowadays, invasive devices such as vane-type flow meter and turbine flow meter are commonly utilized to estimate the flow rates of hydrothermal vents. In- situ observation data obtained by LDCP system and CFD methods will be combined to solve the blind area of LDCP system during in-situ observation measurements. The flow rates profiles obtained in this project will improve the research on the circulation of energy materials and mineralization.

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43

Maruyama, Y., K. Furuhata, T. Saito, R. Kita, N. Shinyashiki, S. Yagihara, and D. Kurita. "Comparison of Biometric Measurements Using Dielectric Spectroscopy and Blood Flow Meter." Transactions of the Materials Research Society of Japan 45, no. 4 (August 1, 2020): 153–56. http://dx.doi.org/10.14723/tmrsj.45.153.

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44

Borgos, John. "Laser Doppler monitoring of cerebral blood flow." Neurological Research 18, no. 3 (June 1996): 251–55. http://dx.doi.org/10.1080/01616412.1996.11740415.

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45

Choi, Christine M., and Richard G. Bennett. "Laser Dopplers to Determine Cutaneous Blood Flow." Dermatologic Surgery 29, no. 3 (March 2003): 272–80. http://dx.doi.org/10.1046/j.1524-4725.2003.29042.x.

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46

Petrig, Benno L. "Choroidal blood flow by laser Doppler flowmetry." Optical Engineering 34, no. 3 (March 1, 1995): 746. http://dx.doi.org/10.1117/12.195229.

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47

CHOI, CHRISTINE M., and RICHARD G. BENNETT. "Laser Dopplers to Determine Cutaneous Blood Flow." Dermatologic Surgery 29, no. 3 (March 2003): 272–80. http://dx.doi.org/10.1097/00042728-200303000-00014.

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48

Krupp, Serge. "Evaluation of gingival microcirculation by a laser-Doppler flow-meter. Preliminary results." Plastic and Reconstructive Surgery 85, no. 3 (March 1990): 485. http://dx.doi.org/10.1097/00006534-199003000-00052.

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49

Kosaka, Ryo, Masahiro Nishida, Osamu Maruyama, Tatsuya Hidaka, Takeshi Okubo, and Takashi Yamane. "Improvement of measurement performance of miniaturized mass-flow meter for an axial flow blood pump." Journal of Life Support Engineering 20, Supplement (2008): 95. http://dx.doi.org/10.5136/lifesupport.20.supplement_95.

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50

FUKUDA, Kyohei, Ryo KOSAKA, Masahiro NISHIDA, Osamu MARUYAMA, Takashi YAMANE, and Yasuo KAWAGUCHI. "1C16 Development of the Driftless Blood Flow Meter using Pulse Transit Time." Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2013.25 (2013): 109–10. http://dx.doi.org/10.1299/jsmebio.2013.25.109.

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