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1

Shin, Jun-Hwa, Jong Moon Park, A. Ram Kim, Hee Suk Shin, Eun Shin Lee, Min-Kyun Oh, and Chul Ho Yoon. "Lance-Adams Syndrome." Annals of Rehabilitation Medicine 36, no. 4 (2012): 561. http://dx.doi.org/10.5535/arm.2012.36.4.561.

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2

Lee, Ha Lim, and Ju Kang Lee. "Lance-Adams Syndrome." Annals of Rehabilitation Medicine 35, no. 6 (2011): 939. http://dx.doi.org/10.5535/arm.2011.35.6.939.

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3

Withanagama, CJ, R. Gamage, and HPMC Caldera. "Lance-Adams Syndrome." Galle Medical Journal 17, no. 1 (May 29, 2012): 53. http://dx.doi.org/10.4038/gmj.v17i1.4363.

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4

Freund, Brin, Raoul Sutter, and Peter W. Kaplan. "Lance-Adams Syndrome in the Pretargeted Temperature Management Era." Clinical EEG and Neuroscience 48, no. 2 (July 10, 2016): 130–38. http://dx.doi.org/10.1177/1550059416643193.

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Анотація:
Acute posthypoxic myoclonus portends a poor prognosis. Another form of posthypoxic myoclonus, Lance-Adams syndrome, is associated with a better outcome. Differentiating these two entities is important in prognostication and guiding further medical intervention. This can be difficult in the acute setting after hypoxic brain injury but the use of neurophysiologic studies may be helpful. In this article, we present a case of a patient who presented after pulseless electrical activity arrest, underwent targeted temperature management and subsequently developed Lance-Adams syndrome. The neurologic and electroencephalographic findings in Lance-Adams syndrome are discussed with an updated review.
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5

Guo, Yu, Yan Xiao, Li-Fa Chen, De-Hui Yin, and Ruo-Dan Wang. "Lance Adams syndrome: two cases report and literature review." Journal of International Medical Research 50, no. 2 (February 2022): 030006052110599. http://dx.doi.org/10.1177/03000605211059933.

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Анотація:
Hypoxic myoclonus, also known as Lance Adams syndrome, is a rare syndrome that results from the serious brain damage caused by cerebral hypoxia that often follows cardiopulmonary resuscitation. This current case report describes two patients with post-hypoxic myoclonus, both of whom received cardiopulmonary resuscitation. The neurological symptoms of these two patients were significantly improved by the administration of clonazepam and sodium valproate sustained-release tablets. The report presents a literature review detailing the pathogenesis, diagnosis and treatment of Lance Adams syndrome. The timely diagnosis and treatment of Lance Adams syndrome can significantly improve the quality of life of patients. Valproic acid, clonazepam and other antiepileptic drugs can be used. Whether levetiracetam is effective for cortical myoclonus requires further clinical study.
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6

Gudivada, KiranK, Cherian Roy, and ManuM K. Varma. "Lance-Adams Syndrome after Cardiac Arrest." Neurology India 70, no. 1 (2022): 166. http://dx.doi.org/10.4103/0028-3886.338676.

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7

Pokryszko-Dragan, Anna. "Anoxic encephalopathy with myoclonus – Lance-Adams syndrome." Family Medicine & Primary Care Review 4 (2015): 338–40. http://dx.doi.org/10.5114/fmpcr/60413.

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8

Stubblefield, Kassandra, Salman Zahoor, Hasan Sonmezturk, Kevin Haas, Danielle Mattingly, and Bassel Abou-Khalil. "Perampanel is effective against Lance-Adams syndrome." Epileptic Disorders 23, no. 5 (October 2021): 769–71. http://dx.doi.org/10.1684/epd.2021.1329.

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9

Waddell, Adam, Ahmed Dirweesh, Fausto Ordonez, Charles Kososky, Leema Reddy Peddareddygari, and Raji P. Grewal. "Lance–Adams syndrome associated with cerebellar pathology." Journal of Community Hospital Internal Medicine Perspectives 7, no. 3 (July 3, 2017): 182–84. http://dx.doi.org/10.1080/20009666.2017.1340730.

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10

Sanna, Giuseppe D., Antonio Demurtas, Stefano Cossa, Francesca Murgia, Paola Murgia, and Annamaria Ara. "A peculiar case of Lance-Adams syndrome." American Journal of Emergency Medicine 34, no. 2 (February 2016): 342.e5–342.e7. http://dx.doi.org/10.1016/j.ajem.2015.06.033.

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11

Yamada, K., T. Sakurama, N. Soyama, and J. i. Kuratsu. "Gpi pallidal stimulation for Lance-Adams syndrome." Neurology 76, no. 14 (April 4, 2011): 1270–72. http://dx.doi.org/10.1212/wnl.0b013e31821482f4.

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12

Marcellino, Christopher, and Eelco FM Wijdicks. "Posthypoxic action myoclonus (the Lance-Adams syndrome)." BMJ Case Reports 13, no. 4 (April 2020): e234332. http://dx.doi.org/10.1136/bcr-2020-234332.

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13

Steinhoff, Bernhard J., Matthias Bacher, Christoph Kurth, Anke M. Staack, and Reinhold Kornmeier. "Add-on perampanel in Lance–Adams syndrome." Epilepsy & Behavior Case Reports 6 (2016): 28–29. http://dx.doi.org/10.1016/j.ebcr.2016.05.001.

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14

Bozic, Ksenija, Ksenija Gebauer-Bukurov, Lorand Sakalas, Ivana Divjak, and Aleksandar Jesic. "Improvement of post-hypoxic action myoclonus with levetiracetam add-on therapy: A case report." Vojnosanitetski pregled 71, no. 5 (2014): 515–19. http://dx.doi.org/10.2298/vsp1405515b.

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Анотація:
Introduction. Chronic post-anoxic myoclonus, also known as Lance-Adams syndrome, may develop following hypoxic brain injury, and is resistant to pharmacological therapy. Case report. The patient we presented developed post-anoxic action myoclonus with severe, completely incapacitating myoclonic jerks. Myoclonus did not respond to the treatment with commonly used agents, i.e. valproate and clonazepam alone or in combination. Improvement of the action myoclonus was observed only after adding levetiracetam. Conclusion. Although Lance-Adams syndrome may not be fully curable at this point, levetiracetam appears to be a promising agent that can significantly improve functional level and overall quality of life of patients with this disorder.
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15

N., Venkatarathnamma P., Krishna Prasad Anne, and Srinivasa S. V. "A rare case report of Lance-Adams Syndrome." International Journal of Biomedical Research 5, no. 10 (October 30, 2014): 643. http://dx.doi.org/10.7439/ijbr.v5i10.778.

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16

Zhang, Yan-xing, Jian-ren Liu, Biao Jiang, Hui-qin Liu, Mei-ping Ding, Shui-jiang Song, Bao-rong Zhang, et al. "Lance-adams syndrome: a report of two cases." Journal of Zhejiang University SCIENCE B 8, no. 10 (September 2007): 715–20. http://dx.doi.org/10.1631/jzus.2007.b0715.

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17

Galldiks, Norbert, Lars Timmermann, Gereon Rudolf Fink, and Lothar Burghaus. "Posthypoxic Myoclonus (Lance-Adams Syndrome) Treated With Lacosamide." Clinical Neuropharmacology 33, no. 4 (July 2010): 216–17. http://dx.doi.org/10.1097/wnf.0b013e3181e1613f.

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18

Zheng, Judy, Zachary McCleary, Mustafa Al-Chalabi, Khaled Gharaibeh, and Ajaz Sheikh. "Lance-Adams syndrome: Case series and literature review." Brain Disorders 11 (September 2023): 100086. http://dx.doi.org/10.1016/j.dscb.2023.100086.

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19

Ghosh, Ritwik, Arpan Maity, Uttam Biswas, Shambaditya Das, and Julián Benito-León. "Lance-Adams syndrome: An unusual complication of snakebite envenomation." Toxicon 209 (April 2022): 50–55. http://dx.doi.org/10.1016/j.toxicon.2022.02.008.

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20

Öztürk, Gülşah, İrem Taşçı, Mustafa Yavuz Samanci, and Selçuk Peker. "Is deep brain stimulation useful in Lance–Adams syndrome?" Neurology Asia 26, no. 3 (September 2021): 617–20. http://dx.doi.org/10.54029/2021ykj.

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Анотація:
Lance–Adams syndrome (LAS) is a chronic post-hypoxic myoclonus that occurs after successful cardiopulmonary resuscitation. Although many drugs are available to treat this condition, the underlying mechanism of the disease is yet to be understood. Deep brain stimulation (DBS) has been attempted and proven to be partially successful in treating LAS in several cases. Here, we present a 40-year-old woman who developed myoclonus subsequent to cardiopulmonary arrest (CPA) that occurred after her first cesarean delivery at the age of 26 years. The patient underwent implantation of bilateral globus pallidus interna (GPi)-DBS about 14 years after disease onset. Regarding Unified Myoclonus Rating Scale (UMRS), 8% and 20% improvements were observed in action and resting myoclonus, respectively, with high-frequency stimulation as a result of the 3-year follow-up study. In this case, neuromodulation therapy applied 14 years after hypoxia-causing LAS was not sufficiently beneficial.
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21

Nigam, Gaurav, Sachin Babu, C. Peter, and C. Peter. "Lance–Adams syndrome: A special case of a mother." Indian Journal of Critical Care Medicine 20, no. 9 (2016): 548–50. http://dx.doi.org/10.4103/0972-5229.190372.

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22

Lee, Ji Ho, and Dong Hun Lee. "Successful case of Lance-Adams syndrome treatment with early use of perampanel after targeted therapeutic hypothermia." Neurology Asia 28, no. 2 (June 2023): 445–47. http://dx.doi.org/10.54029/2023uax.

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Анотація:
Perampanel (PER), approved as an antiseizure medication in 2012, is a selective non-competitive antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. PER is used as an add-on medication to treat partial-onset and primary generalized tonic-clonic seizures. In addition, positive effects have been reported in some patients with epileptic myoclonic convulsions in idiopathic systemic and progressive myoclonic epilepsy. We treated a male patient with post-hypoxic nonepileptic myoclonus (Lance-Adams syndrome) by adding PER to classic antiseizure medications after 10 days of targeted therapeutic hypothermia. Myoclonus movement, which showed no improvement with other antiseizure medications (valproate, levetiracetam, and clonazepam) administered for 9 days, gradually improved after PER was started. In addition, myoclonus recurred when the drug was withheld due to patient’s dry mouth or pickled extremities. By reintroducing PER, myoclonus improved without other side effects. For this reason, we believe that the early introduction of PER in Lance-Adams syndrome after cardiac arrest is worth considering.
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23

Lim, Michelle L., Rachel R. Z. Lim, JongChie C. Tien, Shawn Z. Z. Lim, and Yi Lin Lee. "Lance Adams Syndrome After Hypoxic Cardiac Arrest: A Case Report." A&A Practice 16, no. 8 (August 2022): e01605. http://dx.doi.org/10.1213/xaa.0000000000001605.

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24

López, Sandra Jurado, and Sandra Jurado López. "Post anoxic myoclonic encephalopathy syndrome or Lance- Adams: Case report." Journal of the Neurological Sciences 429 (October 2021): 119579. http://dx.doi.org/10.1016/j.jns.2021.119579.

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25

Castellanos, Joel P., Sean R. Smith, and Ryan Stork. "Poster 319: Levetiracetam Used as Monotherapy in Lance-Adams Syndrome." PM&R 9 (September 2017): S233. http://dx.doi.org/10.1016/j.pmrj.2017.08.259.

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26

Wu, I.-Kung Peter, and Kevin O' Connor. "Poster 92 Rehabilitation of Lance-Adams Syndrome: A Case Report." PM&R 7 (September 2015): S121. http://dx.doi.org/10.1016/j.pmrj.2015.06.131.

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27

Lagrand, T., and A. Winogrodzka. "Late relapse myoclonus in a case of Lance-Adams syndrome." Case Reports 2013, no. 29 1 (November 29, 2013): bcr2013201543. http://dx.doi.org/10.1136/bcr-2013-201543.

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28

Hussain, Nadeem, and Thomas K. Watanabe. "Poster 18 Lance-Adams Syndrome: Rehabilitation of Chronic Posthypoxic Myoclonus." PM&R 3 (September 2011): S181. http://dx.doi.org/10.1016/j.pmrj.2011.08.072.

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29

Stoever, Jonathan, Christine Nguyen, Syed Ahsan, and John Cardasis. "Lance-Adams Syndrome Following Cardiac Arrest Secondary to Cocaine Overdose." Chest 152, no. 4 (October 2017): A351. http://dx.doi.org/10.1016/j.chest.2017.08.377.

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30

Freund, Brin, and Peter W. Kaplan. "Differentiating Lance-Adams syndrome from other forms of postanoxic myoclonus." Annals of Neurology 80, no. 6 (November 14, 2016): 956. http://dx.doi.org/10.1002/ana.24814.

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31

LOWENHAAR, GABRIEL, and JESSICA GONZALEZ. "OUT-OF-HOSPITAL CARDIAC ARREST COMPLICATED BY LANCE-ADAMS SYNDROME." CHEST 166, no. 4 (October 2024): A2511—A2512. http://dx.doi.org/10.1016/j.chest.2024.06.1529.

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32

Tristán, Melina Samara Rangel, Ericka Giovanna Gonzalez Gonzalez, Yasmin Sarahi Rebolledo Vazquez, Karalam Guadalupe Torres Jiménez, Arellano Navarro Consuelo Estephani, Rafael Garcia Resendiz, Juan Carlos Rivas Rodríguez, and Mishell Estefania Heredia Leal. "Post-hypoxic myoclonus (Lance-Adams Syndrome) in post-cardiorespiratory arrest, a case presentation in elderly." South Florida Journal of Development 5, no. 9 (September 9, 2024): e4339. http://dx.doi.org/10.46932/sfjdv5n9-010.

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Анотація:
A clinical case report is presented of an elderly adult recovering from cardiac arrest who developed generalized myoclonus or Lance Adams syndrome in a tertiary care hospital. Myoclonus is defined as a sudden, brief muscle contraction (1). The Lance Adams Syndrome is a form of post- hypoxic myoclonus, characterized by action myoclonus that typically involve the trunk, face, and extremities, and whose onset is days to weeks after a hypoxic brain injury. (2) The incidence of post-hypoxic myoclonus is 1. 3 cases per 100,000 people per year, so its differential diagnosis represents a challenge. The etiology may be secondary to cardiorespiratory arrest, anesthetic and surgical accidents, in addition to heart disease and drug overdose. Acute post-hypoxic myoclonus begins hours after the injury, sometimes begins as myoclonic status epilepticus, and if the patient survives, he will progress to a chronic phase with a poor or low life expectancy. Treatment is controversial, several articles agree that patients have shown better response to Levetiracetam, Magnesium Valproate, Lacosamide and Clonazepam.
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33

HARPER, S. J., and R. G. WILKES. "Posthypoxic myoclonus (the Lance-Adams syndrome) in the intensive care unit." Anaesthesia 46, no. 3 (March 1991): 199–201. http://dx.doi.org/10.1111/j.1365-2044.1991.tb09409.x.

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34

Yadavmali, T., and A. S. Lane. "The Lance-Adams Syndrome: Helpful or Just Hopeful, after Cardiopulmonary Arrest." Journal of the Intensive Care Society 12, no. 4 (October 1, 2011): 324–28. http://dx.doi.org/10.1177/175114371101200416.

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35

Pandya, Vishal, and Khalil S. Husari. "The Use of Perampanel in the Treatment of Lance-Adams Syndrome." Journal of Epilepsy Research 14, no. 2 (December 10, 2024): 97–101. https://doi.org/10.14581/jer.24016.

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Анотація:
Lance Adams syndrome (LAS) is characterized by chronic action or intention myoclonus resulting from cerebral hypoxia. Perampanel, a non-competitive antagonist of aamino-3-hydroxy-5methyl-4 isooxazoleproprionic acid glutamate receptor, has demonstrated some efficacy in myoclonic epilepsy and other types of myoclonus. We report significant benefit in a patient with LAS treated with add on perampanel and provide a review of the relevant literature. In our case, a male patient in his 30s was found pulseless with unknown down time. The patient developed post anoxic myoclonus within 1 week from cardiac arrest. Patient continued to suffer from intractable myoclonus despite being treated with brivaracetam, valproic acid, and clonazepam. Perampanel was added to his medication regimen and up-titrated to 12 mg daily over 1-2 weeks. This resulted in significant improvement in frequency and severity of myoclonus for about 6 months. Growing evidence exists for perampanel as an adjunctive treatment in patients with post hypoxic myoclonus or LAS. A review of the available literature, comprised of case reports and case series, and suggests a potential role for perampanel in patients with LAS. Further study is warranted including controlled trials of perampanel use in post hypoxic myoclonus.
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36

UDURGUCU, Muhammed, Nazik AŞILIOĞLU YENER, Ömer Gökhan ÇELİK, and Seher ESER KAYIKCI. "Lance Adams syndrome following post-hypoxic myoclonic status epilepticus in an adolescent patient with chronic renal failure: A case report." Journal of Experimental and Clinical Medicine 38, no. 3 (April 23, 2021): 379–80. http://dx.doi.org/10.52142/omujecm.38.3.32.

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Анотація:
Myoclonic contractions that may occur after hypoxia might be related to post-hypoxic status epilepticus (PHSE) or Lance Adams syndrome (LAS). It is important to distinguish these two myoclonic conditions in terms of treatment and prognosis. In the literature, both PHSE and LAS have not been reported in pediatric age group including adolescents. Here we report an adolescent case with chronic renal failure who developed PHSE and then LAS after a long-term cardiopulmonary resuscitation.
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37

Subramanian, Mohanakkannan, Sakthi Velayudham, Malcolm Jeyaraj, S. Arunan, Sowmini Perumal, and Kranthi Mohan. "A Case of Lance Adams Syndrome in a Patient with Attempted Hanging." Indian Journal of Critical Care Medicine 26, no. 9 (August 31, 2022): 1052–53. http://dx.doi.org/10.5005/jp-journals-10071-24299.

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38

Malhotra, Suchitra, and Kumar Mohinder. "Lance-Adams syndrome: Difficulties surrounding diagnosis, prognostication, and treatment after cardiac arrest." Anesthesia: Essays and Researches 6, no. 2 (2012): 218. http://dx.doi.org/10.4103/0259-1162.108339.

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39

Hussein, Omar, Himanshu Chokhawala, and Eduardo Gonzalez-Toledo. "NEW OBSERVATIONS ON THE TREATMENT OF LANCE ADAMS SYNDROME; A CASE REPORT." Journal of Neurology, Neurosurgery & Psychiatry 87, no. 12 (November 15, 2016): e1.4-e1. http://dx.doi.org/10.1136/jnnp-2016-315106.101.

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40

Yamaoka, Hisayasu, Nobuoki Tomemori, and Keiichi Hayama. "The Lance-Adams syndrome following cardiopulmonary resuscitation: A report of two cases." Journal of Anesthesia 8, no. 3 (September 1994): 349–51. http://dx.doi.org/10.1007/bf02514665.

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41

Saiz-Sepulveda, M. A., M. Garcia-Fernandez, F. J. Martinez-Orozco, I. Villalibre-Valderrey, and F. Jiménez. "41. Post-anoxic myoclonic encephalopathy (Lance–Adams syndrome) after prolonged cardiopulmonar resucitation." Clinical Neurophysiology 120, no. 4 (April 2009): e143. http://dx.doi.org/10.1016/j.clinph.2008.09.069.

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42

Asahi, Takashi, Daina Kashiwazaki, Nobuhiro Dougu, Genko Oyama, Shutaro Takashima, Kortaro Tanaka, and Satoshi Kuroda. "Alleviation of myoclonus after bilateral pallidal deep brain stimulation for Lance–Adams syndrome." Journal of Neurology 262, no. 6 (May 1, 2015): 1581–83. http://dx.doi.org/10.1007/s00415-015-7748-x.

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43

Arpesella, R., C. Dallocchio, C. Arbasino, R. Imberti, R. Martinotti, and S. J. Frucht. "A Patient with Intractable Posthypoxic Myoclonus (Lance-Adams Syndrome) Treated with Sodium Oxybate." Anaesthesia and Intensive Care 37, no. 2 (March 2009): 314–18. http://dx.doi.org/10.1177/0310057x0903700214.

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44

John, Florence S., and Parisa Salehi. "Poster 240: Lance-Adams Syndrome: A Rare Sequela of Hypoxic Encephalopathy: A Case Report." PM&R 10 (September 2018): S80. http://dx.doi.org/10.1016/j.pmrj.2018.08.252.

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45

Liron, L., M. Chambost, P. Depierre, D. Peillon, and C. Combe. "Efficacité de l'acide valproïque sur les myoclonies d'action postanoxiques (syndrome de Lance et Adams)." Annales Françaises d'Anesthésie et de Réanimation 17, no. 10 (January 1998): 1247–49. http://dx.doi.org/10.1016/s0750-7658(99)80033-1.

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46

Ferlazzo, Edoardo, Sara Gasparini, Vittoria Cianci, Andrea Cherubini, and Umberto Aguglia. "Serial MRI findings in brain anoxia leading to Lance–Adams syndrome: a case report." Neurological Sciences 34, no. 11 (March 15, 2013): 2047–50. http://dx.doi.org/10.1007/s10072-013-1356-2.

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47

Genton, Pierre, Renzo Guerrini, and Shailendra Jain. "Effect of alcohol on action myoclonus in Lance-Adams syndrome and progressive myoclonus epilepsy." Movement Disorders 7, no. 1 (1992): 92. http://dx.doi.org/10.1002/mds.870070122.

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48

Siddiqui, Sameer A., and Zainab A. Naji. "Poster 208: Chronic Post-Hypoxic Myoclonus (Lance-Adams Syndrome) After Cardiac Arrest: A Case Report." PM&R 9 (September 2017): S198—S199. http://dx.doi.org/10.1016/j.pmrj.2017.08.149.

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Rosenblum, David S. "Poster 12: Lance-Adams Syndrome: Effective Treatment and Functional Improvement with Phenytoin. A Case Report." PM&R 1 (September 2009): S108. http://dx.doi.org/10.1016/j.pmrj.2009.08.026.

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Birthi, Pravardhan, Chadwick Walters, Oscar Ortiz Vargas, and Ninad Karandikar. "The Use of Intrathecal Baclofen Therapy for Myoclonus in a Patient With Lance Adams Syndrome." PM&R 3, no. 7 (July 2011): 671–73. http://dx.doi.org/10.1016/j.pmrj.2010.12.023.

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