Добірка наукової літератури з теми "Lactam Based Molecules"
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Статті в журналах з теми "Lactam Based Molecules"
Bai, Yuchen, Leina Dou, Weilin Wu, Zhimin Lu, Jiaqian Kou, Jianzhong Shen, Kai Wen та Zhanhui Wang. "Anti-Metatype Antibody Screening, Sandwich Immunoassay Development, and Structural Insights for β-Lactams Based on Penicillin Binding Protein". Molecules 26, № 18 (13 вересня 2021): 5569. http://dx.doi.org/10.3390/molecules26185569.
Повний текст джерелаBecker, D., M. Botoshansky, N. Gasper, F. H. Herbstein, and M. Karni. "2-Phenyl-4-hydroxyphthalazin-1-one: A Benzoannelated Derivative of Maleic Hydrazide." Acta Crystallographica Section B Structural Science 54, no. 5 (October 1, 1998): 671–76. http://dx.doi.org/10.1107/s0108768197015760.
Повний текст джерелаCox, Robin A. "Lactams in sulfuric acid. The mechanism of amide hydrolysis in weak to moderately strong aqueous mineral acid media." Canadian Journal of Chemistry 76, no. 6 (June 1, 1998): 649–56. http://dx.doi.org/10.1139/v98-012.
Повний текст джерелаPestana-Nobles, Roberto, Yani Aranguren-Díaz, Elwi Machado-Sierra, Juvenal Yosa, Nataly J. Galan-Freyle, Laura X. Sepulveda-Montaño, Daniel G. Kuroda, and Leonardo C. Pacheco-Londoño. "Docking and Molecular Dynamic of Microalgae Compounds as Potential Inhibitors of Beta-Lactamase." International Journal of Molecular Sciences 23, no. 3 (January 31, 2022): 1630. http://dx.doi.org/10.3390/ijms23031630.
Повний текст джерелаTwamley, Brendan, Niamh M. O'Boyle, and Mary J. Meegan. "Azetidin-2-ones: structures of antimitotic compounds based on the 1-(3,4,5-trimethoxyphenyl)azetidin-2-one core." Acta Crystallographica Section E Crystallographic Communications 76, no. 8 (July 3, 2020): 1187–94. http://dx.doi.org/10.1107/s2056989020008555.
Повний текст джерелаShiri, Pezhman. "Novel Hybrid Molecules Based on triazole-β-lactam as Potential Biological Agents". Mini-Reviews in Medicinal Chemistry 21, № 5 (2021): 536–53. http://dx.doi.org/10.2174/18755607mtewaotyn5.
Повний текст джерелаMolteni, Elena, Giovanni Onida, Matteo Ceccarelli, and Giancarlo Cappellini. "Ab Initio Spectroscopic Investigation of Pharmacologically Relevant Chiral Molecules: The Cases of Avibactam, Cephems, and Idelalisib as Benchmarks for Antibiotics and Anticancer Drugs." Symmetry 13, no. 4 (April 3, 2021): 601. http://dx.doi.org/10.3390/sym13040601.
Повний текст джерелаKurmaz, Svetlana V., Natalia V. Fadeeva, Vladislav M. Ignat’ev, Vladimir A. Kurmaz, Sergei A. Kurochkin, and Nina S. Emel’yanova. "Structure and State of Water in Branched N-Vinylpyrrolidone Copolymers as Carriers of a Hydrophilic Biologically Active Compound." Molecules 25, no. 24 (December 18, 2020): 6015. http://dx.doi.org/10.3390/molecules25246015.
Повний текст джерелаShlaes, D. M., та C. Currie-McCumber. "Mutations altering substrate specificity in OHIO-1, and SHV-1 family β-lactamase". Biochemical Journal 284, № 2 (1 червня 1992): 411–15. http://dx.doi.org/10.1042/bj2840411.
Повний текст джерелаMaity, Arindam, Sarmi Sardar, Shilpa Chatterjee, Nripendra Nath Bala, Sudhan Debnath та Debanjan Sen. "De-Novo Design of Hits Against New Delhi Metallo-β-Lactamase Enzyme". International Journal of Quantitative Structure-Property Relationships 7, № 2 (квітень 2022): 1–13. http://dx.doi.org/10.4018/ijqspr.290010.
Повний текст джерелаДисертації з теми "Lactam Based Molecules"
Nichols, Derek Allen. "Structure-Based Design of Novel Inhibitors and Ultra High Resolution Analysis of CTX-M Beta-Lactamase." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5284.
Повний текст джерелаChien-Hsien, Kuo. "Molecular phylogeny and evolution of hagfish based on mtDNA and lactate dehydrogenase genes." 2000. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0021-2603200719104655.
Повний текст джерелаKuo, Chien-Hsien, and 郭建賢. "Molecular phylogeny and evolution of hagfish based on mtDNA and lactate dehydrogenase genes." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/03269412909281228290.
Повний текст джерела國立臺灣師範大學
生物研究所
89
Abstracts The study included molecular phylogeny of hagfish and evolution of lactate dehydrogenase. The mitochondrial DNA sequences from the large ribosomal RNA gene may be of great value for systematic and phylogenetic studies within families. Partial sequences of the 16S rRNA gene were obtained for comparisons among the following hagfish species, Paramyxine nelsoni, P. sheni, P. taiwanae, P. yangi, P. cheni, Eptatretus burgeri, E. stouii, E. cirrhatus, Myxine glutinosa, M. formosana, M. circifrons, M. sp1 and M. sp2. The boundary of first four Paramyxine species from 16S rRNA sequences is ambiguous; however, they are valid based on our further unpublished isozyme data as well as the gill aperture arrangement pattern. The present molecular data show that the genus Paramyxine is polyphyletic. Eptatretus and Paramyxine form a clade, but their included species can be grouped separately into two different subfamilies, the Myxininae and Eptatretinae. The phylogenetic pattern is not congruent with the number of branchial pouches or branchial apertures proposed by Nelson (1994) and Fernholm (1998), who addressed the evolutionary trend of hagfish as being from polybranchiates to monobranchiates and with all hagfish belonging to a monophyletic group. Furthermore, the larger genetic distance between P. cheni and the other Eptatretinae species suggest that P. cheni could be as a basal taxa in Eptatretinae. A new genus and species of Rubicundus oligoporos collected from the northeastern coast of Taiwan is described here. Rubicundus is distinguished by pink body coloration. Rubicundus oligoporos is a five-gilled species with a three-cusp multicusp on the anterior rows and a two-cusp one on the posterior rows. The putative taxonomic position of Rubicundus is discussed based on mitochondrial 16S rRNA gene fragment sequences. In order to understand the expression of the multiple LDH isozymes in aves, the brain, eye, heart, liver, muscle, and testis were analyzed. Horizontal starch gel electrophoresis was used to examine isozymes of L-lactate dehydrogenase in 4 families and 7 genera of lizards and 33 aves species assigned to 6 orders. Like all other vertebrates, bords possess 2 fundamental LDH loci (LDH-A and LDH-B). A LDH-C product of the third locus was detected in only 8 species of birds and 4 lizards and, for the first time, was reported from the Passeriformes and lizards. The results of this study and those of other previous research suggest that avian LDH-C, reptile LDH-C, and mammalian LDH-C may be orthologous, and may have been derived from ancestor amniote LDH-A. The present study has determined a cDNA sequence of LDH-A from the muscle of hagfish, it contains 1428 nucleotides including a protein-encoding sequences of 1026 nucleotides, the 5’(54 nucleotides) and 3’ (342 nucleotides) untranslated region. The hagfish LDH-A protein that we deduced from the nucleotide sequence is 341 amino acids long. Compared to the other vertebrate LDH, the sequence added 8 amino acids in the low hydrophobicity region at position 220-227. Hagfish LDH unique 9 positions exhibit alternative amino acid those conserved in all vertebrates. None of the alternative amino acids positions makes up the active center. Of the 10 positions that are diagnostic for LDH-A versus LDH-B in the gnathostome vertebrate examined, the hagfish LDH-A sequence resemble LDH-A at four, LDH-B at two, and neither at four. Hagfish LDH, like that of the all vertebrate LDH-As is also missing an amino acid at the penultimate position. The hagfish sequence, with its greater similarity to chordate LDH-A sequence in this region, provides additional evidence that the amino acid was added in the common ancestor of LDH-Bs. Our phylogenetic conclusions that LDH of hagfish muscle is a ancestral LDH-A and the lamprey single locus condition is due to gene loss. Both distance and maximum parsimony analysis strongly reject a relationship of hagfish LDH-A with lamprey LDH.
Barbosa, João Alberto Cunha. "Development of a poly(L-Lactic acid) based drug release system." Master's thesis, 2015. http://hdl.handle.net/1822/41125.
Повний текст джерелаNanomedicine and controllable drug delivery systems have recently initiated their way into therapeutics. Faulty and, many times, ineffective approaches that conventional medicine uses need to be replaced by novel and smart materials that assure that a drug is delivered in the right place, at the right time. Polymeric materials are now widely used to produce drug delivery vehicles with tunable characteristics and, if needed, triggered releases. Although several polymeric materials are already being used to produce drug delivery systems it is, however, necessary to reach an active control of the drug release rate. Hence, the addition of a stimuli-sensitive component to the system that could trigger or increase the drug release rate would be of great interest. Therefore, during this work a polymeric platform containing a drug carrier (zeolite) and a stimuli-sensitive component (Terfenol-D) was developed. Firstly, a theoretical and experimental screening involving different zeolites with different characteristics (structure, crystal size, Si/Al ratio and counter ion) and loading methods with different solvents (hexane, ethanol and acetone) was performed in order to understand their influence in the loading of a model drug – Ibuprofen. Next, preparation of poly(L-lactic acid) membranes was optimized by testing three different polymer concentration. The membranes were prepared by freeze-drying method. Preliminary results from the molecular modelling studies indicated that faujasite and beta polymorph- A structures were the ones allowing a greater displacement of the drug inside the pores. Experimental trials indicated that hexane was the solvent providing greater loadings. From the tested zeolites, the nanosized faujasite (crystal size of ~250nm) was selected due to its complete drug release at 24h. Moreover, membranes prepared with 5(wt/vol.)% presented the best morphological and mechanical characteristics that were maintained after the incorporation of the zeolite and Terfenol-D particles. Comparing the four different drug release systems prepared (loaded zeolites; loaded membranes; membranes with loaded zeolites; and membranes with loaded zeolites and Terfenol-D under magnetic fields) it is clear that the systems present significant differences in the release kinetics and mechanisms. The membranes containing IBU-loaded zeolites appear to present a combination between the release of IBU-loaded membranes and the IBU-loaded zeolites. The release assays with the membranes containing loaded zeolite and Terfenol-D particles confirmed the influence of the applied magnetic fields in the release ratio. When the trigger is applied the Korsmeyer-Peppas model indicates a super case-II transport, indicating that the release of the drug is being driven mostly by a swelling or erosion mechanism, explained by the movement of the magnetostrictive particles when subject to the magnetic field.
A nanomedicina e os sistemas de entrega controlada de fármacos iniciaram recentemente a sua utilização terapêutica. Várias práticas utilizadas pela medicina convencional apresentam diversas limitações e são, muitas vezes, ineficazes, sendo necessária a sua substituição por novos materiais que assegurem que um fármaco é entregue no local certo, no momento adequado. Apesar de vários materiais poliméricos serem já utilizados para produzir sistemas de entrega de fármacos com características moduláveis é no entanto necessário ter um controlo ativo da taxa de libertação. Assim, a adição de um componente sensível a um estímulo que pudesse iniciar ou acelerar a libertação seria uma grande vantagem. Deste modo, neste trabalho foi desenvolvida uma plataforma polimérica contendo um veículo no qual o fármaco esta integrado (zeólito) e um componente sensível a campos magnéticos (Terfenol-D). Inicialmente, foi realizado um estudo teórico e experimental envolvendo diversos zeólitos com diferentes características (estrutura, tamanho do cristal, razão Si/Al e contra-ião) e métodos de incorporação do fármaco usando diferentes solventes (hexano, etanol e acetona), de maneira a entender a influência dos diferentes parâmetros na incorporação de um fármaco modelo – ibuprofeno. Seguidamente, foi otimizada a preparação das membranas de ácido poli(L-láctico) para a incorporação dos restantes componentes, tendo sido testadas quatro concentrações de polímero. Os resultados demonstraram que a as estruturas faujasite e beta polimorph-a foram as que apresentaram maior mobilidade para a molécula do fármaco e o hexano mostrou ser o solvente que permite maiores taxas de encapsulação. Dos zeólitos testados, foi selecionado o que apresentava libertação total do seu conteúdo às 24h (faujasite com tamanho de cristal de ~250nm). Os testes às membranas mostraram que a membrana com 5 (m/vol.)% de polímero apresentava as características morfológicas e mecânicas mais adequadas, mantendo-as após a incorporação do zeólito e das partículas de Terfenol-D Comparando as cinéticas de libertação dos quatro sistemas de libertação preparados (zeólitos e membranas carregados; membranas com zeólitos carregados; e membranas com zeólitos carregados e Terfenol-D sob campos magnéticos) claras diferenças são observadas. A libertação de IBU das membranas contendo zeólitos carregados aparenta ser uma combinação das cinéticas de libertação dos zeólitos e das membranas carregados. Os ensaios de libertação com as membranas contendo zeólito e Terfenol- D sob campos magnéticos confirmaram a influência do estímulo na taxa de libertação. O resultado foi um transporte denominado super caso-II, indicando que o mecanismo de libertação é controlado sobretudo pelas variações na matriz polimérica, causada pelo movimento das partículas magnetostritivas.
Частини книг з теми "Lactam Based Molecules"
Delpiccolo, Carina M. L., Maitena Martinez-Amezaga, and Ernesto G. Mata. "Recent Approaches Toward the Generation of Molecular Diversity Based on β-Lactam Structures." In Beta-Lactams, 129–62. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55621-5_5.
Повний текст джерелаBarber, Michael S., Ulrich Giesecke, Arno Reichert, and Wolfgang Minas. "Industrial Enzymatic Production of Cephalosporin-Based β-Lactams." In Molecular Biotechnolgy of Fungal beta-Lactam Antibiotics and Related Peptide Synthetases, 179–215. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/b99261.
Повний текст джерелаCoelho-Rocha, Nina D., Fernanda A. L. Barroso, Laísa M. Tavares, Ester S. S. dos Santos, Vasco Azevedo, Mariana M. Drumond, and Pamela Mancha-Agresti. "Main Features of DNA-Based Vectors for Use in Lactic Acid and Update Protocols." In Methods in Molecular Biology, 285–304. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0872-2_16.
Повний текст джерелаTuzar, Zdeněk. "Molecular Characterization." In Lactam-Based Polyamides, 95–131. CRC Press, 2019. http://dx.doi.org/10.1201/9780367813062-4.
Повний текст джерелаLe Rouzic, Morgan, Pauline Bruniaux, Cyril Raveschot, François Krier, Vincent Phalip, Rozenn Ravallec, Benoit Cudennec, and François Coutte. "Lactobacillus Use for Plant Fermentation: New Ways for Plant-Based Product Valorization." In Lactobacillus - A Multifunctional Genus [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.104958.
Повний текст джерелаZong, Liang, Jingning Zhang, Dan Li, Shaohui Sui, Yanhua Xiao, Jian Li, Meng Liu, Bo Zhuang, Daxue Li, and Weihui Wu. "A Rhodamine-Based Probe for Detection of Nerve Agents Simulants." In Advances in Transdisciplinary Engineering. IOS Press, 2021. http://dx.doi.org/10.3233/atde210333.
Повний текст джерелаDinodia, Monica. "Greener Approach towards the Synthesis of Nitrogen Based Heterocycles." In Strategies Towards the Synthesis of Heterocycles and Their Applications [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108489.
Повний текст джерелаBhukya, Bhima, Chandrasekhar Banoth, Praveen K. Keshav, MD Saddam Hussain, and Shanthipriya Ajmera. "Biotechnological Production of Various Fungal Metabolites and their Applications in White Biotechnology." In Mycology: Current and Future Developments, 255–86. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815040340122040019.
Повний текст джерелаTaber, Douglass F. "The Tan/Chen/Yang Synthesis of Schindilactone A." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0088.
Повний текст джерелаТези доповідей конференцій з теми "Lactam Based Molecules"
Rob, Mohammad A., and Frank C. Franceschetti. "Atmospheric Multi-Component Pollution Analysis Using CO2 Laser." In Laser Applications to Chemical Analysis. Washington, D.C.: Optica Publishing Group, 1992. http://dx.doi.org/10.1364/laca.1992.wc7.
Повний текст джерелаHill, S. C., M. D. Barnes, W. B. Whitten, and J. M. Ramsey. "Modeling Fluorescence Collection from Single Molecules in Liquid Microspheres." In Laser Applications to Chemical and Environmental Analysis. Washington, D.C.: Optica Publishing Group, 1996. http://dx.doi.org/10.1364/lacea.1996.lwd.7.
Повний текст джерелаLermer, N., M. D. Barnes, C.-Y. Kung, W. B. Whitten, and J. M. Ramsey. "High-Speed Single Molecule Detection in Microdroplet Streams." In Laser Applications to Chemical and Environmental Analysis. Washington, D.C.: Optica Publishing Group, 1996. http://dx.doi.org/10.1364/lacea.1996.lwb.7.
Повний текст джерелаTerekhova, M. I., E. V. Rogacheva, I. A. Derevyanchenko, and L. A. Kraeva. "WHOLE-GENOME SEQUENCING-BASED ANTIBIOTIC RESISTANCE PROFILE OF LISTERIA MONOCYTOGENES STRAINS FROM SAINT-PETERSBURG AND THE VOLOGDA REGION." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-109.
Повний текст джерелаWilley, K. F., V. Vorsa, and N. Winograd. "Molecular Photoionization and Chemical Imaging." In Laser Applications to Chemical and Environmental Analysis. Washington, D.C.: Optica Publishing Group, 1998. http://dx.doi.org/10.1364/lacea.1998.ltub.4.
Повний текст джерелаDovichi, Norman J., Shade Wu, and Da Yung Chen. "High Sensitivity Fluorescence Detection of Biological Molecules." In Laser Applications to Chemical Analysis. Washington, D.C.: Optica Publishing Group, 1990. http://dx.doi.org/10.1364/laca.1990.tha1.
Повний текст джерелаYeung, Edward S. "Laser Based Analytical Measurements In Liquids." In Laser Applications to Chemical Analysis. Washington, D.C.: Optica Publishing Group, 1987. http://dx.doi.org/10.1364/laca.1987.ma4.
Повний текст джерелаJett, James H., Lloyd C. Davis, Jong Hoon Hahn, Richard A. Keller, Letitia Krakowski, Babetta Marrone, John C. Martin, Robert Ratliff, Newton K. Seitzinger, and E. Brooks Shera. "Single Molecule Detection in Flowing Sample Streams As An Approach to DNA Sequencing." In Laser Applications to Chemical Analysis. Washington, D.C.: Optica Publishing Group, 1990. http://dx.doi.org/10.1364/laca.1990.tha3.
Повний текст джерелаKudo, Hiroyuki, Yusuke Suzuki, Yoshiki Tojo, Haruna Saito, and Keigo Enomoto. "Sweat Lactic Acid Monitoring System using Adhesive Plaster-based Sweat Sampling Device." In 2019 IEEE 14th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS). IEEE, 2019. http://dx.doi.org/10.1109/nems.2019.8915655.
Повний текст джерелаHieftje, Gary M. "New Laser-Based Measurements in Analytical Spectrometry: From Remote Testing to Thomson Scattering." In Laser Applications to Chemical Analysis. Washington, D.C.: Optica Publishing Group, 1987. http://dx.doi.org/10.1364/laca.1987.ma5.
Повний текст джерела