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Добірка наукової літератури з теми "L18A"

Автор: Grafiati
Опубліковано: 11 березня 2023

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Статті в журналах з теми "L18A"

1

Aoyama, Yuji, Yuen-Ling Chan, Oded Meyuhas, and Ira G. Wool. "The primary structure of rat ribosomal protein L18a." FEBS Letters 247, no. 2 (April 24, 1989): 242–46. http://dx.doi.org/10.1016/0014-5793(89)81344-4.

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2

Han, Sun‐Young, and Mieyoung Choi. "Human ribosomal protein L18a interacts with hnRNP E1." Animal Cells and Systems 12, no. 3 (January 2008): 143–48. http://dx.doi.org/10.1080/19768354.2008.9647167.

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3

Sommer, W., C. Arlinde, L. Caberlotto, A. Thorsell, P. Hyytia, and M. Heilig. "CNS expression of diacylglycerol kinase iota and L18A mRNAs." Molecular Psychiatry 6, no. 1 (December 14, 2000): 5. http://dx.doi.org/10.1038/sj.mp.4000831.

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4

Dhar, D., K. Mapa, R. Pudi, P. Srinivasan, K. Bodhinathan, and S. Das. "Human ribosomal protein L18a interacts with hepatitis C virus internal ribosome entry site." Archives of Virology 151, no. 3 (September 30, 2005): 509–24. http://dx.doi.org/10.1007/s00705-005-0642-6.

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5

Ntwasa, Monde, Sean G. S. C. Buchanan, and Nicholas J. Gay. "Drosophila ribosomal protein L18a: cDNA sequence, expression and chromosomal localization of the gene." Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1218, no. 2 (June 1994): 210–12. http://dx.doi.org/10.1016/0167-4781(94)90014-0.

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6

Yant, Stephen R., Julie Park, Yong Huang, Jacob Giehm Mikkelsen, and Mark A. Kay. "Mutational Analysis of the N-Terminal DNA-Binding Domain of Sleeping Beauty Transposase: Critical Residues for DNA Binding and Hyperactivity in Mammalian Cells." Molecular and Cellular Biology 24, no. 20 (October 15, 2004): 9239–47. http://dx.doi.org/10.1128/mcb.24.20.9239-9247.2004.

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ABSTRACT The N-terminal domain of the Sleeping Beauty (SB) transposase mediates transposon DNA binding, subunit multimerization, and nuclear translocation in vertebrate cells. For this report, we studied the relative contributions of 95 different residues within this multifunctional domain by large-scale mutational analysis. We found that each of four amino acids (leucine 25, arginine 36, isoleucine 42, and glycine 59) contributes to DNA binding in the context of the N-terminal 123 amino acids of SB transposase, as indicated by electrophoretic mobility shift analysis, and to functional activity of the full-length transposase, as determined by a quantitative HeLa cell-based transposition assay. Moreover, we show that amino acid substitutions within either the putative oligomerization domain (L11A, L18A, L25A, and L32A) or the nuclear localization signal (K104A and R105A) severely impair its ability to mediate DNA transposition in mammalian cells. In contrast, each of 10 single amino acid changes within the bipartite DNA-binding domain is shown to greatly enhance SB's transpositional activity in mammalian cells. These hyperactive mutations functioned synergistically when combined and are shown to significantly improve transposase affinity for transposon end sequences. Finally, we show that enhanced DNA-binding activity results in improved cleavage kinetics, increased SB element mobilization from host cell chromosomes, and dramatically improved gene transfer capabilities of SB in vivo in mice. These studies provide important insights into vertebrate transposon biology and indicate that Sleeping Beauty can be readily improved for enhanced genetic research applications in mammals.
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7

Gazda, Hanna T., Mee Rie Sheen, Natasha Darras, Hal Shneider, Colin A. Sieff, Sarah E. Ball, Edyta Niewiadomska, et al. "Mutations of the Genes for Ribosomal Proteins L5 and L11 Are a Common Cause of Diamond-Blackfan Anemia." Blood 110, no. 11 (November 16, 2007): 421. http://dx.doi.org/10.1182/blood.v110.11.421.421.

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Abstract Diamond-Blackfan anemia (DBA), a form of congenital red cell aplasia with marked clinical heterogeneity and increased risk of malignancy, has been associated with mutations in ribosomal protein (RP) gene RPS19 in 25% of probands and in RPS24 or RPS17 in ∼2% of patients. Thus, DBA appears to be a disorder of ribosome synthesis. To test the hypothesis that mutations in other RP genes may also cause DBA, we carried out direct sequencing of candidate RP genes. Genomic DNA samples from 96 unrelated DBA probands (14 familial and 82 sporadic cases) without RPS19 or RPS24 mutations were screened for mutations in RPS3a, RPS13, and RPS16 (previous studies revealed that RPs S19, S24, S3a, S13, and S16 are involved in binding of eIF-2 to the 40S subunit); RP genes L18, L13A, L36, L28, L18A, L40, S5, S9, S11, and S28 (located on chromosome 19); and RP genes, L5, L11, L22, S8, and S27 (on chromosome 1). PCR primers were designed to amplify the coding exons and intron/exon boundaries. We found multiple mutations in two RP genes, L5 and L11. Subsequently we sequenced these two genes in 42 additional DNA samples from DBA probands. In total, we screened 5′UTR, promoter and coding regions, and exon/intron boundaries of RPL5 and RPL11 in 138 DBA unrelated probands. We identified 14 mutations in RPL5 in 138 probands (∼10%), 13 of which are nonsense mutations, deletions or insertions of 1–5 nucleotides causing frameshift and premature termination. One missense mutation, 418G>A, results in a G140S substitution. We found nine mutations in RPL11 in138 DBA probands (6.5%), including five acceptor or donor splice site mutations (introns 1–4) and four deletions or insertions of 1–4 nucleotides causing frameshifts (codons 32-120). None of these sequence changes were found on the NCBI (http://www.ncbi.nlm.nih.gov/SNP/) or the HapMap (http://www.hapmap.org/) SNP lists. Both genes, as well as RPL23 have recently been demonstrated by others to activate the p53 tumor suppressor protein by inhibiting MDM2-mediated p53 ubiquitination and degradation. Moreover, knockdown of any of these genes by siRNAs markedly reduced p53 induction by the ribosomal biogenesis stressor, actinomycin-D. These findings suggest that DBA patients with mutated L5 and L11 proteins may have inadequate p53 pathway activation and (consistent with clinical observations) be at increased risk for neoplasia. We are currently investigating the role of RPL5 and RPL11 mutations in ribosomal biogenesis and in the p53-mediated cell cycle arrest and apoptosis in DBA patients.
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8

Zhang, Yihao, Yuying Jin, Qian Gong, Zhi Li, Lihong Zhao, Xiao Han, Jinglong Zhou, Fuguang Li, and Zhaoen Yang. "Mechanismal analysis of resistance to Verticillium dahliae in upland cotton conferred by overexpression of RPL18A-6 (Ribosomal Protein L18A-6)." Industrial Crops and Products 141 (December 2019): 111742. http://dx.doi.org/10.1016/j.indcrop.2019.111742.

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9

Sommer, W., C. Arlinde, L. Caberlotto, A. Thorsell, P. Hyytia, and M. Heilig. "Differential expression of diacylglycerol kinase iota and L18A mRNAs in the brains of alcohol-preferring AA and alcohol-avoiding ANA rats." Molecular Psychiatry 6, no. 1 (December 14, 2000): 103–8. http://dx.doi.org/10.1038/sj.mp.4000823.

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10

Mottaghi-Dastjerdi, N., M. Soltany-Rezaee-Rad, Z. Sepehrizadeh, G. Roshandel, F. Ebrahimifard, and N. Setayesh. "Identification of novel genes involved in gastric carcinogenesis by suppression subtractive hybridization." Human & Experimental Toxicology 34, no. 1 (May 8, 2014): 3–11. http://dx.doi.org/10.1177/0960327114532386.

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Gastric cancer (GC) is one of the most common and life-threatening types of malignancies. Identification of the differentially expressed genes in GC is one of the best approaches for establishing new diagnostic and therapeutic targets. Furthermore, these investigations could advance our knowledge about molecular biology and the carcinogenesis of this cancer. To screen for the overexpressed genes in gastric adenocarcinoma, we performed suppression subtractive hybridization (SSH) on gastric adenocarcinoma tissue and the corresponding normal gastric tissue, and eight genes were found to be overexpressed in the tumor compared with those of the normal tissue. The genes were ribosomal protein L18A, RNase H2 subunit B, SEC13, eukaryotic translation initiation factor 4A1, tetraspanin 8, cytochrome c oxidase subunit 2, NADH dehydrogenase subunit 4, and mitochondrially encoded ATP synthase 6. The common functions among the identified genes include involvement in protein synthesis, involvement in genomic stability maintenance, metastasis, metabolic improvement, cell signaling pathways, and chemoresistance. Our results provide new insights into the molecular biology of GC and drug discovery: each of the identified genes could be further investigated as targets for prognosis evaluation, diagnosis, treatment, evaluation of the response to new anticancer drugs, and determination of the molecular pathogenesis of GC.
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Більше джерел

Дисертації з теми "L18A"

1

Das, Priyanka. "Study of the L13a residues required for ribosomal function." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1331762160.

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2

Poddar, Darshana Ph D. "Study of Role of Ribosomal Protein L13a in Resolving Inflammation." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1400587453.

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3

Kour, Ravinder. "Insights into the ribosomal, extra-ribosomal and developmental role of RP L13a in mammalian model." Cleveland State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=csu1572548728931568.

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4

Von, Hagen William J. "Analysis of the L1A, L1M, L2A, and L2F Low-Pressure Turbine Blades Using Large-Eddy Simulation." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1470045392.

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5

Viegas, Taisa Giordano [UNESP]. "Interação do peptídeo antimicrobiano L1A com membrana modelo: efeito do pH e carga da vesícula." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/127655.

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Made available in DSpace on 2015-09-17T15:24:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-12-16. Added 1 bitstream(s) on 2015-09-17T15:47:13Z : No. of bitstreams: 1 000846885.pdf: 505151 bytes, checksum: ad11474b84c8cf10e34014ace8c2c242 (MD5)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Peptdeos antimicrobianos possuem em geral cadeias curtas, carga líquida positiva devido ao excesso dos res duos b asicos e são ricos em amino acidos hidrof obicos. Possuem um grande potencial farmacológico, com atividade antimicrobiana modulada por interações eletrost aticas e hidrof obicas. Neste trabalho utilizou-se o pept deo sintético L1A (IDGLKAIWKKV ADLLKNT NH2), que devido aos res duos de acido asp artico e lisinas constituintes de sua cadeia, possui carga liquida +3, em pH neutro. Foram analisadas as insuficiências do pH e da carga de ves culas aniônicas na adsorçãao do pept deo. Este estudo utilizou medidas de potencial eletrocin etico de ves culas e experimentos de titulação monitorados por dicro smo circular (CD). A adsorção do L1A a LUVs de POPC e misturas POPC/POPG em diferentes proporções de POPG, foi medida nos pHs 4, 7 e 10. Os espectros de dicro smo circular dos peptídeos, na presença de vesícula, apresentaram caracter sticas de estruturas helicoidais, enquanto apresentaram estruturas desordenadas em tampão. As frações de hélices obtidas são maiores quando o pept deo adsorve em ves culas com maiores quantidades de POPG, indicando forte contribuição eletrost atica. As constantes aparentes de adsorção dos pept deos as membranas modelo foram calculadas atrav es da elipticidade de CD normalizada em 222 nm, obtidas por titulações de pept deo com ves culas. A a - nidade do pept deo a ves culas aniônicas e signi cativamente maior do que a ves culas zwitteriônicas, o que refor ca a import ancia das interçõeoes eletrost aticas no processo de adsorção do pept deo na bicamada. O efeito conjunto de carga das ves culas e de pH resultaram em signi cativa regulação de carga do pept deo resultando em valores de carga efetiva alta em pH 4,0 devido a protonação dos res duos de asp artico. Em pH 10,0 a pequena carga efetiva calculada deve-se as desprotona ações do N-terminal e das lisinas...
Antimicrobial peptides have in general short chains, positive net charge due to the excess of basic residues and are rich in hydrophobic amino acids. They have pharmacological potential as antimicrobial agents and their activity is modulated by electrostatic and hydrophobic interactions. In this work, we used the synthetic peptide L1A (IDGLKAIWKKV ADLLKNT NH2) that due to its acid and basic residues have an net charge +3, at neutral pH. The e ects of the pH and of the charges of anionic vesicles on the adsorption of L1A were analized. This study used measurement of electrokinetic potential of vesicles and titration experiments monitored by circular dichroism spectroscopy (CD). Adsorption of L1A to POPC and POPC/POPG LUVs in di erent POPG contents were assessed in the pH 4.0, 7.0 and 10.0. Circular dichroism spectra of the peptides in the presence of vesicles showed to features of helical structures; while random coil structures were observed at bu er for all the used pHs. The helical content was evaluated and showed to increase when the peptide adsorbs into vesicles with increasing amounts of POPG, indicating that there is a strong electrostatic contribution. Partition coe cients were calculated through the normalized CD ellipticities at 222 nm and showed that the a nity of the peptide for anionic model membranes is e ectively higher than those found for zwitterionic ones. It reinforces the importance of the electrostatic contribution to the process of peptide-lipid interaction. The coupled e ect of the vesicle charge and pH lead to signi cant charge regulation of the peptide resulting in high values of e ective charge at pH 4.0 due to the deprotonation of aspartic acid residues. At pH 10.0 the estimated e ective charge is small as a consequence of the deprotonation of both N-terminus and the lysines. The electrostatic and interfatial free energies seems to be additive only at pH 4.0, especially for the bilayers with higher content...
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6

Viegas, Taisa Giordano. "Interação do peptídeo antimicrobiano L1A com membrana modelo : efeito do pH e carga da vesícula /." São José do Rio Preto, 2014. http://hdl.handle.net/11449/127655.

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Orientador: João Ruggiero Neto
Banca: Alexandre Suman de Araujo
Banca: Fernando Luis Barroso da Silva
Resumo: Peptdeos antimicrobianos possuem em geral cadeias curtas, carga líquida positiva devido ao excesso dos res duos b asicos e são ricos em amino acidos hidrof obicos. Possuem um grande potencial farmacológico, com atividade antimicrobiana modulada por interações eletrost aticas e hidrof obicas. Neste trabalho utilizou-se o pept deo sintético L1A (IDGLKAIWKKV ADLLKNT ���� NH2), que devido aos res duos de acido asp artico e lisinas constituintes de sua cadeia, possui carga liquida +3, em pH neutro. Foram analisadas as insuficiências do pH e da carga de ves culas aniônicas na adsorçãao do pept deo. Este estudo utilizou medidas de potencial eletrocin etico de ves culas e experimentos de titulação monitorados por dicro smo circular (CD). A adsorção do L1A a LUVs de POPC e misturas POPC/POPG em diferentes proporções de POPG, foi medida nos pHs 4, 7 e 10. Os espectros de dicro smo circular dos peptídeos, na presença de vesícula, apresentaram caracter sticas de estruturas helicoidais, enquanto apresentaram estruturas desordenadas em tampão. As frações de hélices obtidas são maiores quando o pept deo adsorve em ves culas com maiores quantidades de POPG, indicando forte contribuição eletrost atica. As constantes aparentes de adsorção dos pept deos as membranas modelo foram calculadas atrav es da elipticidade de CD normalizada em 222 nm, obtidas por titulações de pept deo com ves culas. A a - nidade do pept deo a ves culas aniônicas e signi cativamente maior do que a ves culas zwitteriônicas, o que refor ca a import^ancia das interçõeoes eletrost aticas no processo de adsorção do pept deo na bicamada. O efeito conjunto de carga das ves culas e de pH resultaram em signi cativa regulação de carga do pept deo resultando em valores de carga efetiva alta em pH 4,0 devido a protonação dos res duos de asp artico. Em pH 10,0 a pequena carga efetiva calculada deve-se as desprotona ações do N-terminal e das lisinas...
Abstract: Antimicrobial peptides have in general short chains, positive net charge due to the excess of basic residues and are rich in hydrophobic amino acids. They have pharmacological potential as antimicrobial agents and their activity is modulated by electrostatic and hydrophobic interactions. In this work, we used the synthetic peptide L1A (IDGLKAIWKKV ADLLKNT ���� NH2) that due to its acid and basic residues have an net charge +3, at neutral pH. The e ects of the pH and of the charges of anionic vesicles on the adsorption of L1A were analized. This study used measurement of electrokinetic potential of vesicles and titration experiments monitored by circular dichroism spectroscopy (CD). Adsorption of L1A to POPC and POPC/POPG LUVs in di erent POPG contents were assessed in the pH 4.0, 7.0 and 10.0. Circular dichroism spectra of the peptides in the presence of vesicles showed to features of helical structures; while random coil structures were observed at bu er for all the used pHs. The helical content was evaluated and showed to increase when the peptide adsorbs into vesicles with increasing amounts of POPG, indicating that there is a strong electrostatic contribution. Partition coe cients were calculated through the normalized CD ellipticities at 222 nm and showed that the a nity of the peptide for anionic model membranes is e ectively higher than those found for zwitterionic ones. It reinforces the importance of the electrostatic contribution to the process of peptide-lipid interaction. The coupled e ect of the vesicle charge and pH lead to signi cant charge regulation of the peptide resulting in high values of e ective charge at pH 4.0 due to the deprotonation of aspartic acid residues. At pH 10.0 the estimated e ective charge is small as a consequence of the deprotonation of both N-terminus and the lysines. The electrostatic and interfatial free energies seems to be additive only at pH 4.0, especially for the bilayers with higher content...
Mestre
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7

Kapasi, Purvi. "An Insight into GAIT Complex Mediated Translational Silencing." Cleveland State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1232567504.

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8

Rocha, Carolina da Silva. "Identificação de componentes da via de sinalização mediada pela proteína NIK, um receptor que interage com a proteína NSP de geminivírus." Universidade Federal de Viçosa, 2007. http://locus.ufv.br/handle/123456789/4824.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Proteins of the family of LRR-RLKs (receptor-like-kinases with leucine-rich repeats) have a conceptual relevance in signaling events but in plants information regarding function is limited to a few members of this family. The receptors NIK1, NIK2 and NIK3 of Arabidopsis thaliana belong to the sub-family LRRII-RLK and were initially identified by their capacity to interact with the geminivirus NSP protein. In response to an unknown stimulus, NSP-interacting kinases (NIKs) are activated after the formation of dimmers and intermolecular autophosphorylation. The inhibition of autophosphorylation of NIK by NSP and the activation of NIK genes increase the susceptibility to viral infection, suggesting that this protein is involved in a defense pathway against geminivirus infection. The downstream components of this pathway, mediated by the protein NIK, have yet to be identified. In the present study, the biochemical and functional characterization of two ribosomal proteins, L10 and L18 were described, these being capable of interacting with the protein NIK via the yeast two-hybrid system. In vitro studies demonstrated that the protein NIK is capable of phosphorylating the protein L10, but not L18. Of the members of the LRRIIRLK family, the protein NIK2 phosphorylates L10, while NIK3 presents a low capacity for phosphorylation of the substrate. However, the development protein SERK1 does not use L10 as a substrate. Assays of transient expression in tobacco plants, revealed that the L18 protein is located in the cytoplasm, as well as around the nucleus and the nucleoli of some cells. In turn, in 97% of the cells, L10 was localized only in the cytoplasm, although it was also found in the nucleus, in approximately 3% of the observed cells. The transient expression of NIK1 and NIK2 redirects the L10 protein to the nucleus in approximately 30% of the cells. In contrast, NIK3 does not relocalize the L10 protein to the nucleus, and L18 does not change its localization in the presence of the NIKs. In plants infected with TGMV, a change only in the cytoplasmic localization of L10 was observed, accumulating in points of the cytoplasm when not co-localized with NIK. To prove genetically the interactions of L10-NIK and L18-NIK, null alleles for the genes L10 and L18 de Arabidopsis, containing T-DNA insertion, were obtained and inoculated with CaLCuV. The inactivation of the genes L10 and L18 restored the elevated susceptibility phenotype of nik1 and the knockout plants, principally l10, presented severe symptoms and high rates of infection when compared with the wild columbia plants. The results of this work are consistent with a model that places the ribosomal proteins L10 and L18 as functional components of the defense signaling pathway mediated by the protein NIK, L10 being a component immediately downstream of the transmembrane receptor.
As proteínas da família das LRR-RLKs (receptor-like-quinases com repetições ricas em leucina) possuem uma relevância conceitual em eventos de sinalização mas, em plantas, a informação funcional ainda é restrita a alguns membros desta família. Os receptores NIK1, NIK2 e NIK3 de Arabidopsis thaliana pertecem à sub-familia LRRII-RLK e foram inicialmente identificados pela sua capacidade de interagir com a proteína NSP de geminivírus. Em resposta a um estímulo desconhecido, NSP-interacting kinases (NIKs) são ativadas após a formação de dímeros e autofosforilação intermolecular. A inibição da autofosforilação de NIK por NSP e a inativação de genes NIKs aumenta a suscetibilidade à infecção viral, sugerindo que esta proteína estaria envolvida em uma via de defesa contra a infecção por geminivírus. Os componentes downstream dessa via de sinalização, mediada pela proteína NIK, ainda não foram identificados. No presente estudo foi descrita a caracterização bioquímica e funcional de duas proteínas ribossomais, L10 e L18, as quais foram capazes de interagir com a proteína NIK através do sistema de duplo híbrido de leveduras. Estudos in vitro demonstraram que a proteína NIK é capaz de fosforilar a proteína L10, mas não L18. Entre os membros da família LRRII-RLK, a proteína NIK2 fosforila L10, enquanto NIK3 apresenta uma baixa capacidade de fosforilação do substrato. No entanto, a proteína de desenvolvimento SERK1 não utiliza L10 como substrato. Ensaios de expressão transiente, em plantas de tabaco, revelaram que a proteína L18 está localizada no citoplasma, bem como ao redor do núcleo e no nucléolo de algumas células. Por sua vez, em 97% das células, L10 foi localizada apenas no citoplasma, embora tenha sido encontrada no núcleo, em aproximadamente 3% das células observadas. A expressão transiente de NIK1 e NIK2 redireciona a proteína L10 para o núcleo em aproximadamente 30% das células. Em contraste, NIK3 não relocaliza a proteína L10 para o núcleo, e L18 não muda sua localização na presença das NIKs. Em plantas infectadas com TGMV, observou-se mudança apenas na localização citoplasmática de L10, acumulando-se em pontos do citoplasma quando não colocalizada com NIK. Para se comprovar geneticamente as interações de L10-NIK e L18- NIK, alelos nulos para os genes L10 e L18 de Arabidopsis, contendo inserção de T-DNA, foram obtidos e inoculados com o CaLCuV. A inativação dos genes L10 e L18 recapitulou o fenótipo de suscetibilidade aumentada de nik1 e as plantas knockout, principalmente l10, apresentaram sintomas severos e taxa de infecção alta quanto comparados com as plantas selvagens columbia. Os resultados deste trabalho são consistentes com um modelo que posiciona as proteínas ribossomais L10 e L18 como componentes funcionais da via de sinalização de defesa mediada pela proteína NIK, sendo L10 um componente imediatamente downstream ao receptor transmembrana.
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9

Lefèvre, Charlène. "Coreshine, un phénomène et un outil." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066460/document.

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Bien que les grains de poussières représentent 1% du milieu interstellaire en masse, leur étude est essentielle pour comprendre le contenu et la structure des nuages interstellaires. Les grains de poussière, après avoir quitté leurs lieux de formation, se dispersent dans le milieu diffus avant d’être rassemblés lors de la formation des nuages moléculaires denses. C’est lors de cette étape qu’ils grossissent, notamment par coagulation, et acquièrent des manteaux de glaces. Ces changements morphologiques modifient également leurs propriétés optiques (absorption, diffusion et émission). Cependant, leur composition comme leur taille et leur forme restent difficiles à déterminer à partir des observations et constituent un problème hautement dégénéré. L’utilisation des longueurs d’onde en émission n’est pas suffisante pour lever cette dégénérescence dans les cœurs denses, lieu de formation des futures étoiles et planètes. En revanche la diffusion peut dominer l’absorption à 3.6 et 4.5 μm, ce phénomène appelé coreshine, est particulièrement utile pour sonder les parties les plus denses des nuages. La présence de coreshine dans plus d’une centaine de nuages de notre Galaxie permet d’éliminer bon nombre de modèles de poussières. La modélisation multi–longueurs d’onde en 3 dimensions est une approche nécessaire pour caractériser la balance entre l’absorption du rayonnement et sa diffusion. Alors que la plupart des travaux se concentrent sur l’absorption et la réémission du rayonnement, la diffusion, souvent délaissée, permet d’apporter une vision complète du transfert de rayonnement dans les nuages denses
Even though dust grains contribute only to 1% of the interstellar medium mass, their study is crucial to understand both the structure and content of interstellar clouds. Dust grains leave their birth places, spread out into the diffuse medium before being gathered together again when dense molecular clouds form. During this last stage, they grow, by coagulation especially, and they acquire ice mantles composed mainly of water. These morphological changes also modify their optical properties (absorption, scattering, and emission). However, it remains a highly degenerate issue to determine their composition, size, and shape from observations. In particular, I will highlight that using wavelengths associated to dust emission is not sufficient to investigate the dense cores, where stars and planets will form. I will show that scattering can dominate the absorption at 3.6 and 4.5 μm, and that this phenomenon called coreshine is a powerful tool to investigate the densest parts of molecular clouds. The coreshine detection in more than one hundred clouds of our Galaxy allows us to eliminate a large number of dust models. Multi–wavelength 3D modeling is mandatory to characterize the balance between the absorption and the scattering of the radiation field. While most of the work about dust focus on absorption and re–emission of the radiation, I will present how scattering, often neglected, brings a complete picture of the radiative transfer inside dense clouds
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Vinci, Samuel J. "CFD SIMULATIONS FOR THE EFFECT OF UNSTEADY WAKES ON THE BOUNDARY LAYER OF A HIGHLY LOADED LOW PRESSURE TURBINE AIRFOIL (L1A)." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1307111386.

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Книги з теми "L18A"

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The Building Regulations 2000: Conservation of fuel and power in new dwellings : approved document L1A. [Norwich]: TSO, 2010.

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A, Freeman Kerry, Rivele Richard J, and Chilton Book Company, eds. Chilton's repair & tune-up guide, Datsun Nissan pick-ups, 1970-84: All U.S. and Canadian models of L16, L18, L20B, Z20, Z22, Z24 gasoline engines, SD22, SD25 diesel engines, including 4-wheel drive. Radnor, Pa: Chilton Book Co., 1985.

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Communities and Local Government Staff. Approved Document L1A: Conservation of Fuel and Power. Taylor & Francis Group, 2010.

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Hidalgo, Álvaro. El valor del medicamento desde una perspectiva social. Actualización 2020. Fundación Weber, 2021. http://dx.doi.org/10.37666/l18-2020.

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At Your Request: Grades K-3 (Accelerated Reader Book Set L18). Renaissance Learning Inc, 2002.

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Corporation, Intertec Publishing. Kubota Shop Manual Models L185, L235, L245, L275, L285, L295, L305,Ll345, L355 (K-3). Primedia Business Directories & Books, 1987.

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Building Regulations Approved Document L1a: Conservation of Fuel And Power-new Dwellings. Stationery Office, 2006.

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Cournane, Ailís. In defence of the child innovator. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198747840.003.0002.

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This chapter confronts the two principal arguments levelled against the child-as-innovator approach to language change: (1) child innovations cannot underlie historical innovations because child innovations resolve before adulthood, when they could diffuse (e.g. Traugott and Dasher 2005; Diessel 2011), and (2) parallels must hold between child innovations and historical innovations, but parallels do not hold in the domain of morphosyntax (e.g. Diessel 2012). I argue that both parallel and oppositional alignments are predicted by the two possible innovation-types children make when solving the Mapping Problem (Clark 1977, 1993, i.a.); in short, different L1A processes underlie different types of change. I further argue that input-divergent analyses at most need to persist into the teenage years, when they can be diffused via the sociolinguistic change powerhouse of teenage peer groups (e.g. Labov 2012), and may also be reinforced and prolonged in childhood via peer-to-peer acquisition and bilingualism contexts.
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Domestic heating compliance guide: Compliance with approved documents L1A: New dwellings and L1B: Existing dwellings : the Building Regulations 2000 as amended 2006. London: TSO, 2006.

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Great Britain: Department for Communities and Local Government. Building Act 1984: The Building Regulations and the Building Regulations 2000, Building Regulations 2000, schedule 1, part L, approved documents L1A, L1B, L2A, L2B, multi-foil Insulation. Stationery Office, The, 2009.

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Частини книг з теми "L18A"

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Bühlmann, Albert A., Ernst B. Völlm, and Peter Nussberger. "Das Rechenmodell ZH-L16A." In Tauchmedizin, 127–32. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-642-55939-6_7.

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Bühlmann, Albert A. "Das Rechenmodell ZH-L16A." In Tauchmedizin, 85–88. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-97413-7_7.

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Bühlmann, Albert A. "Das Rechenmodell ZH-L16A." In Tauchmedizin, 85–87. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-97623-0_7.

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Bühlmann, Albert A. "Das Rechenmodell ZH-L16A." In Tauchmedizin, 84–87. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-97256-0_7.

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Pagani, L., A. J. Apponi, A. Bacmann, L. Cambrésy, M. Fich, G. Lagache, M. A. Miville-Deschênes, F. Motte, and J. R. Pardo. "L183 (134N) Dust, Gas and Depletion." In Springer Proceedings in Physics, 439–42. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-18902-9_78.

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Christiansen, J., and R. A. Garrett. "How Do Protein L18 and 5S RNA Interact?" In Springer Series in Molecular Biology, 253–69. New York, NY: Springer New York, 1986. http://dx.doi.org/10.1007/978-1-4612-4884-2_15.

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Nabedryk, E., J. Breton, J. Wachtveitl, K. A. Gray, and D. Oesterhelt. "FTIR Spectroscopy of The P+Q A - /PQA State in Met L248→Thr, Ser L244→Gly, Phe M197→Tyr, Tyr M210→Phe, Tyr M210→Leu, Phe L181—Tyr and Phe L181—Tyr M210→Tyr L181—Phe M210 Mutants of RB. Shaeroides." In The Photosynthetic Bacterial Reaction Center II, 147–53. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3050-3_18.

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Yuan, Huadong, Jing Lv, Yong Yu, and Jiang Chang. "A Fast Acquisition Algorithm for L1C Based on L1CA and L1C Combined Detection." In Lecture Notes in Electrical Engineering, 689–98. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-29193-7_65.

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Vos, Marten H., Michael R. Jones, C. Neil Hunter, Jacques Breton, Jean-Christophe Lambry, and Jean-Louis Martin. "Femtosecond spectroscopy and vibrational coherence of membrane-bound RCs of Rhodobacter sphaeroides genetically modified at Positions M210 and L181." In The Reaction Center of Photosynthetic Bacteria, 271–80. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61157-5_21.

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Salavaravu, Laxmana Raju, and Lingaraju Dumpala. "Multi-objective Optimization of Submerged Friction Stir Welding Process Parameters for Improved Mechanical Strength of AA6061 Weld Bead by Using Taguchi-L18-Based Gray Relational Analysis." In Advances in Applied Mechanical Engineering, 965–73. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-1201-8_103.

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Тези доповідей конференцій з теми "L18A"

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Su, Xiulan, Yiling Hou, Shibin Yuan, Maojie Tian, Bing Sun, Jun Li, Guangfu Wu, Yan Song, and Wanru Hou. "cDNA, genomic sequence cloning and sequence analysis of ribosomal protein L18A gene( RPL18A ) from the Giant Panda (Ailuropoda melanoleuca)." In 2010 3rd International Conference on Biomedical Engineering and Informatics (BMEI). IEEE, 2010. http://dx.doi.org/10.1109/bmei.2010.5639805.

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Lattanzi, Valerio, Paola Caselli, and Luca Bizzocchi. "A PRESTELLAR CORE 3MM LINE SURVEY: MOLECULAR COMPLEXITY IN L183." In 72nd International Symposium on Molecular Spectroscopy. Urbana, Illinois: University of Illinois at Urbana-Champaign, 2017. http://dx.doi.org/10.15278/isms.2017.wf06.

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Sanders, Darius D., Chase A. Nessler, Rolf Sondergaard, Marc D. Polanka, Christopher Marks, Mitch Wolff, and Walter F. O’Brien. "A CFD and Experimental Investigation of Unsteady Wake Effects on a Highly Loaded Low Pressure Turbine Blade at Low Reynolds Number." In ASME Turbo Expo 2010: Power for Land, Sea, and Air. ASMEDC, 2010. http://dx.doi.org/10.1115/gt2010-22977.

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The flowfield of the L1A low pressure (LP) turbine blade subjected to traversing upstream wakes was experimentally and computationally investigated at an inlet Reynolds number of 25,000. The L1A profile is a high-lift aft-loaded low pressure turbine blade design. The profile was designed to separate at low Reynolds numbers making it an ideal airfoil for use in flow separation control studies. This study applied a new two-dimensional CFD model to the L1A LP turbine blade design using a three-equation eddy-viscosity type transitional flow model developed by Walters and Leylek. Velocity field measurements were obtained by two-dimensional planer particle image velocimetry, and comparisons were made to the CFD predictions using the Walters and Leylek [13] k-kL-ω transitional flow model and the Menter’s [24] k-ω(SST) model. Hotwire measurements and pressure coefficient distributions were also used to compare each model’s ability to predict the wake produced from the wake generator, and the loading on the L1A LP turbine blade profile with unsteady wakes. These comparisons were used to determine which RANS CFD model could better predict the unsteady L1A blade flowfield at low inlet Reynolds number. This research also provided further characterization of the Walters and Leylek transitional flow model for low Reynolds number aerodynamic flow prediction in low pressure turbine blades.
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Chen, Xin, Yu Jade Morton, and Di He. "GPS L1CA/BDS B1I NLOS Signal Measurements and Modeling in Dense Urban Area." In 2020 International Technical Meeting of The Institute of Navigation. Institute of Navigation, 2020. http://dx.doi.org/10.33012/2020.17139.

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Freciozzi, J., P. Muse, A. Almansa, S. Durand, A. Khazaal, and B. Rouge. "SMOS images restoration from L1A data: A sparsity-based variational approach." In IGARSS 2014 - 2014 IEEE International Geoscience and Remote Sensing Symposium. IEEE, 2014. http://dx.doi.org/10.1109/igarss.2014.6946977.

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Zi-Mao Liu, Yi-Ling Hou, Xiang Ding, Wan-Ru Hou, Jun Yang, and Zheng-Song Peng. "CDNA and genomic sequence clonging and analysis of ribosomal protein L10A gene (RPL10A) from giant panda." In 2012 International Conference on Computer Science and Information Processing (CSIP). IEEE, 2012. http://dx.doi.org/10.1109/csip.2012.6308912.

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Yang Hu, Jun Yang, Yi-Ling Hou, Xiang Ding, Zheng-Song Peng, and Wan-Ru Hou. "Cloning and sequence analysis of ribosomal protein L18 gene (rpl18) from Ailuropoda melanoleuca." In 2012 International Conference on Computer Science and Information Processing (CSIP). IEEE, 2012. http://dx.doi.org/10.1109/csip.2012.6308909.

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Salehuddin, F., I. Ahmad, F. A. Hamid, A. Zaharim, Afifah Maheran A. Hamid, P. Susthitha Menon, H. A. Elgomati, B. Yeop Majlis, and P. R. Apte. "Optimization of process parameter variation in 45nm p-channel MOSFET using L18 orthogonal array." In 2012 10th IEEE International Conference on Semiconductor Electronics (ICSE). IEEE, 2012. http://dx.doi.org/10.1109/smelec.2012.6417127.

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Gutkin, Gregory, Geoffrey Whitener, Young Wu, and Kurt P. Rouser. "L1A Turbine Flow Characterization in a Cascade Facility with a T-Bar Turbulence Generator." In 54th AIAA Aerospace Sciences Meeting. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2016. http://dx.doi.org/10.2514/6.2016-0405.

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Ibrahim, Mounir B., Samuel Vinci, Olga Kartuzova, and Ralph J. Volino. "CFD Simulations of Unsteady Wakes on a Highly Loaded Low Pressure Turbine Airfoil (L1A)." In ASME Turbo Expo 2012: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/gt2012-69770.

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A study of a very high lift, low-pressure turbine airfoil in the presence of unsteady wakes was performed computationally and compared against experimental results. The experiments were conducted in a low speed wind tunnel under high (4.9%) and then low (0.6%) freestream turbulence intensity conditions with a flow coefficient (ζ) of 0.7. The experiments were done on a linear cascade with wakes that were produced from moving rods upstream of the cascade with the rod to blade spacing varied from 1 to 1.6 to 2. In the present study two different Reynolds numbers (25,000 and 50,000, based on the suction surface length and the nominal exit velocity from the cascade) were considered. The experimental and computational data have shown that in cases without wakes, the boundary layer separated and did not reattach. The CFD was performed with Large Eddy Simulation (LES) and Unsteady Reynolds-Averaged Navier-Stokes (URANS), Transition-SST, utilizing the finite-volume code ANSYS FLUENT under the same freestream turbulence and Reynolds number conditions as the experiment but only at a rod to blade spacing of 1. With wakes, separation was largely suppressed, particularly if the wake passing frequency was sufficiently high. Similar effect was predicted by 3D CFD simulations. Computational results for the pressure coefficients and velocity profiles were in a reasonable agreement with experimental ones for all cases examined. The 2D CFD efforts failed to capture the three dimensionality effects of the wake and thus were less consistent with the experimental data. As a further computational study, cases were run to simulate higher wake passing frequencies which were not run experimentally. The results of these computational cases showed that an initial 25% increase from the experimental dimensionless wake passing frequency of F = 0.45 greatly reduced the size of the separation bubble, nearly completely suppressing it, however an additional 33% increase on top of this did not prove to have much of an effect.
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Звіти організацій з теми "L18A"

1

Rieu, Pierre, Samira Amraoui, and Marco Restano. Standalone Multi-mission Altimetry Processor (SMAP). European Space Agency, June 2021. http://dx.doi.org/10.5270/esa-cnes.sentinel-3.smap.

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SMAP is a standalone altimeter data processor written in Python 3 (3.7.3). It implements in particular the fully-focused SAR (FF-SAR) processing (both time-domain and frequency-domain algorithms). SMAP is currently able to process Sentinel-3 L1a Ground Segment products. This processor has been developed though studies and projects funded by ESA and CNES.
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