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Добірка наукової літератури з теми "L06C"

Автор: Grafiati

Опубліковано: 11 березня 2023

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Статті в журналах з теми "L06C"

Pešić, Vladimir, and Harry Smit. "Hydrodroma angelieri (Acari, Hydrachnidia: Hydrodromidae) a new water mite species from Corsica based on morphological and DNA barcode evidence." Acarologia 62, no. 1 (January 7, 2022): 3–11. http://dx.doi.org/10.24349/l06c-j0qm.

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In the present study we used morphological data and DNA barcodes to describe a new species, Hydrodroma angelieri sp. nov. from Corsica, France. A high genetic distance of 17.3±0.017% K2P from its molecularly most closely related European congener, H. despiciens (Müller, 1776), supports H. angelieri sp. nov. as a distinct species. Morphologically the new species can be identified on the basis of relatively small leg claws, the presence of only one swimming seta on II-L-5 and 4-6 swimming setae on the anterior surface of IV-L-5. An updated key for the European species of Hydrodroma is provided.

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Friedman, Susan Hatters, and Deborah J. Gould. "Neurosarcoidosis Presenting as Psychosis and Dementia: A Case Report." International Journal of Psychiatry in Medicine 32, no. 4 (December 2002): 401–3. http://dx.doi.org/10.2190/uyub-bhry-l06c-mpcp.

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Neurosarcoidosis is a rare disorder in which psychosis and dementia may occur. They usually appear subsequently to the diagnosis of pulmonary sarcoidosis. We report on a 39-year-old patient who presented with long-term decline and acute onset of psychosis and delirium, and who was found to have neurosarcoidosis.

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Dalezis, Panagiotis, Eleni Geromichalou, Aikaterini Polonifi, Sofia Sagredou, Nikolaos Nikoleousakos, Michael Nikolaou, Vasiliki Sarli, Mihalis I. Panayiotidis, and Dimitrios T. Trafalis. "Azasteroid Alkylators as Dual Inhibitors of AKT and ERK Signaling for the Treatment of Ovarian Carcinoma." Cancers 12, no. 5 (May 16, 2020): 1263. http://dx.doi.org/10.3390/cancers12051263.

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(1) Background: Previous findings show that lactam steroidal alkylating esters display improved therapeutic efficacy with reduced toxicity. The aim of this study was to evaluate the anticancer activity of two newly synthesized aza-steroid alkylators (ENGA-L06E and ENGA-L08E) against human ovarian carcinoma cells, and consequently, the dual inhibition of RAS/PI3K/AKT and RAS/RAF/MEK/ERK signaling pathways, both of which are closely associated with ovarian cancer; (2) Methods: The in vitro cytostatic and cytotoxic effects of ENGA-L06E and ENGA-L08E were evaluated in a panel of five human ovarian cancer cell lines, as well as in in vivo studies. ENGA-L06E and ENGA-L08E, in addition to another two aniline-mustard alkylators, POPAM and melphalan (L-PAM), were utilized in order to determine the acute toxicity and antitumor efficacy on two human ovarian xenograft models. Also, in silico studies were performed in order to investigate the dual inhibition of ENGA-L06E and ENGA-L08E on RAS/PI3K/AKT and RAS/RAF/MEK/ERK signaling pathways; (3) Results: Both, in vitro and in vivo studies demonstrated that ENGA-L06E and ENGA-L08E were significantly more effective with a lower toxicity profile in comparison to POPAM and L-PAM alkylators. Moreover, in silico studies demonstrated that the two new aza-steroid alkylators could act as efficient inhibitors of the phosphorylation of AKT and ERK1/2 molecules; and (4) Conclusions: Both ENGA-L06E and ENGA-L08E demonstrated high anticancer activity through the inhibition of the PI3K-AKT and KRAS-ERK signaling pathways against human ovarian carcinoma, and thus constituting strong evidence towards further clinical development.

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Carpenter, William J., Eric R. Ostmark, and John A. Cornell. "Embryo Cap Removal and High-temperature Exposure -Stimulate Rapid Germination of Needle Palm Seeds." HortScience 28, no. 9 (September 1993): 904–7. http://dx.doi.org/10.21273/hortsci.28.9.904.

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High synchrony, rate, and germination of needle palm [Rhapidophyllum hystrix (Pursh) H.A. Wendle & Drude] seeds were achieved only after removing the sclerotesta and embryo cap, which imposed physical dormancy. After scarification, recently harvested seeds or seeds stored for 12 months at 5C and 100% relative humidity had 96% and 98% final germination (G), with 9 to 11 days required to achieve 50% of final germination (T50) at 30C. Germination temperature controlled G, T50, and days between 10% and 90% of final germination (T90 - T10) of scarified seeds, with respective values of 98%) 9 days, and 5 days at 30C, and 18%, 31 days, and 12 days at 15C. Seeds with 36% moisture at harvest had no reduction in G until moisture was <14%. Germination of seeds with 19% moisture declined from 80% if stored at 0C to 33% if stored at -l0C; no seeds germinated after storage at less than -l0C.

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Jesus, Helenice Silva de, Servio Tulio Alves Cassini, Marcos Vinicius Pereira, Aline Figueredo Dassoler, and Ricardo Franci Gonçalves. "Autochthonous microalgae cultivation with anaerobic effluent: isolation of strains, survivorship, and characterization of the produced biomass." Ambiente e Agua - An Interdisciplinary Journal of Applied Science 14, no. 4 (July 10, 2019): 1. http://dx.doi.org/10.4136/ambi-agua.2362.

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Six Chlorophyta strains were isolated from the effluent of an anaerobic reactor treating municipal wastewater and identified as Desmodesmus sp. L02, Chlorococcum sp. L04, Coccomyxa sp. L05, Chlorella sp. L06, Scenedesmus sp. L08 and Tetradesmus sp. L09. The microalgae strains were cultivated in unsterilized wastewater under laboratory conditions to determine their potential to survive under non-sterile conditions. The strains were also cultivated in sterilized wastewater in order to analyze their nutrient removal potential and characterize the produced biomass. Amongst the isolated microalgae, Chlorella sp. L06 had the highest survivorship percentage (90%) for ten days of culture, whilst Desmodesmus sp. L02 had the lowest, not exceeding 1.8% after 24h of inoculation. The dried biomass of the isolates showed an average of 28.7% of protein, 15.4% of lipids and 14.8% of carbohydrates, with Chlorococcum sp. L04 reaching 29.3% of carbohydrates. In terms of nutrients, nitrogen removal varied from 59.2 to 93%, and phosphorus removal ranged from 79.1 to 95.4%, with Tetradesmus sp. L09 being the most efficient strain.

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To, Naoya, Ippei Sanada, Hikaru Ito, Shinya Morita, Yoshihiko Kanno, and Norihisa Miki. "1P1-L06 Evaluation of Implantable Micro Hemodialysis System." Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2015 (2015): _1P1—L06_1—_1P1—L06_2. http://dx.doi.org/10.1299/jsmermd.2015._1p1-l06_1.

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Kukačka, Vladimír, Lucie Chaloupková, Milada Fialová, Radovan Kopp, and Jan Mareš. "The influence of linseed oil and fish oil supplements to the fatty acid spectrum of common carp (Cyrinus carpio L.) muscle." Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis 57, no. 5 (2009): 183–92. http://dx.doi.org/10.11118/actaun200957050183.

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Effect of addition 6% of linseed oil (designated L06), 6% and 10% of fish oil (R06 and R10) to feed on the fatty acid spectrum of common carp (Cyprinus carpio L.) was investigated. The basic feedmixture which was used as a control variant (K – 34% protein; 9% fat) and the three with oil addition (L06, R06 and R10) were fed to carp fingerling (43.25 g average weight) for 60 days – from 23rd April to 20th June. Before that the fish were fed for 2 month by whey grain and commercial feed for carp fingerling in pond fish-culture (KP feed mixture – 33% protein; 5% fat) at daily feeding rate 1.5% of actually fish mass. This procedure was intended to create feeding conditions closest to those witnessed in market fish farmed in ponds during the vegetation season nevertheless the spectrum of fatty acids present in the fish muscle at the experiment’s beginning did not fully correspond to what was observed in carps living in ponds and fed by cereals.An addition of 6% of linseed oil to the feed lowers the content of the oleic acid and MUFA and, at the same time, it boosts the contents of the α-linoleic acid, n-3 PUFA and the general PUFA in the meat of carp fed on mixtures thus enriched. Additions of 6% and 10% of fish oil to the feed for common carp increases the content of the eicosapentaenoic acid. The 10% addition proved beneficial for also the ratio of n-3/n-6 PUFA. The high content of the docosapentaenoic acid and the general PUFA in the meat of fish as early as the beginning of the experiment resulted in a smaller number of significant changes in the spectrum of fatty acids (particularly the docosahexaenoic acid, PUFA and n-3/n-6 PUFA) found in the fish meat of the L06, R06 and R10 experimental variants.

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Ichihara, Y., Y. Tsuboi, S. Shimoda, T. Asahi, H. Kimura, and H. Fujimoto. "2A1-L06 Oculomotor Control using Images based on Compound Control." Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2007 (2007): _2A1—L06_1—_2A1—L06_2. http://dx.doi.org/10.1299/jsmermd.2007._2a1-l06_1.

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TSUMAKI, Yuichi, Ikumi MAEDA, Shoma KUDO, and Shoji KASAI. "2A2-L06 Flying Control for an Intra-Vehicular Free-Flyer." Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2007 (2007): _2A2—L06_1—_2A2—L06_3. http://dx.doi.org/10.1299/jsmermd.2007._2a2-l06_1.

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Lu, Xiaojie, Junjie He, Yanhua Wu, Na Du, Xiaofan Li, Jianhua Ju, Zhangli Hu, Kazuo Umezawa, and Liyan Wang. "Isolation and Characterization of New Anti-Inflammatory and Antioxidant Components from Deep Marine-Derived Fungus Myrothecium sp. Bzo-l062." Marine Drugs 18, no. 12 (November 26, 2020): 597. http://dx.doi.org/10.3390/md18120597.

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In the present study, four new compounds including a pair of 2-benzoyl tetrahydrofuran enantiomers, namely, (−)-1S-myrothecol (1a) and (+)-1R-myrothecol (1b), a methoxy-myrothecol racemate (2), and an azaphilone derivative, myrothin (3), were isolated along with four known compounds (4–7) from cultures of the deep-sea fungus Myrothecium sp. BZO-L062. Enantiomeric compounds 1a and 1b were separated through normal-phase chiral high-performance liquid chromatography. The absolute configurations of 1a, 1b, and 3 were assigned by ECD spectra. Among them, the new compound 1a and its enantiomer 1b exhibited anti-inflammatory activity, inhibited nitric oxide formation in lipopolysaccharide-treated RAW264.7 cells, and exhibited antioxidant activity in the 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and oxygen radical absorbance capacity assays.

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Більше джерел

Дисертації з теми "L06C"

Dall'Olio, Francesco. "King Tyrannos: la tirannide greca nella letteratura elisabettiana." Doctoral thesis, 2019. http://hdl.handle.net/11562/995099.

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La tesi analizza il modo in cui alcune figure e opere della letteratura greca, collegate al tema della tirannide, vengano riutilizzate all'interno del dibattito relativo alla natura e agli effetti della tirannide nella letteratura del Rinascimento inglese. In particolare, la tesi sottolinea come, in un arco di tempo compreso fra il regno di Enrico VIII e quello di Giacomo I, vari autori appartenenti all'elite culturale inglese utilizzarono soggetti tratti dalla letteratura greca per affrontare il tema in un'ottica che andava contro l'ideologia ufficiale del regno, secondo cui il tiranno era da identificare solo con l'usurpatore del trono.

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Книги з теми "L06C"

DEA-G-l060 German/U.S. Workshop on Electrothermal-Chemical Gun Propulsion. Storming Media, 1998.

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Best-Selling Authors: Grades K-3 (Accelerated Reader Book Set L06). Renaissance Learning Inc, 2002.

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Частини книг з теми "L06C"

[Hutchinson], Mary Wordsworth, and Dorothy Wordsworth. "L06. M. W. And D. W. to Thomas Monkhouse." In The Letters of William and Dorothy Wordsworth, Vol. 4: The Later Years: Part I: 1821–1828 (Second Revised Edition), edited by Ernest De Selincourt and Alan G. Hill, 210–13. Oxford University Press, 2000. http://dx.doi.org/10.1093/oseo/instance.00083258.

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Тези доповідей конференцій з теми "L06C"

Filippi, J. F., D. Arnoux, N. Tubiana, B. Boutière, F. Le Caär, J. Sampol, Lab Hématol, Pr J. Sampol, and Pr Y. Carcassonne. "PLASMINOGEN ACTIVATOR ACTIVITY OF NORMAL AND MALIGNANT MONONUCLEAR HUMAN CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643167.

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Plasminogen activators (PA) are thought to play a role in the invasive and metastatic properties of many types of cancer cells. Though, discrepancies in correlations between fibrinolytic activity and metastatic potential of malignant cells have been described.In this study, we evaluated both tissue type (tPA) and urokinase type (UK) cellular PA activities in different mononuclear cell types : normal T and B human peripheral lymphocytes, B cells from patients with chronic lymphocytic leukemia (CLL), human blood monocytes, alveolar macrophages, U 937, RAJI and JM cell 1ines.Mononuclear cells were isolated by Ficoll-hypaque gradients and monocytes by plastic adhesion. T and B cells were separated by a rosetting technique using sheep red blood cells. Cellular extracts were prepared by 0.5 % Triton X 100 buffer treatment followed by sonication and centrifugation 10 ' at 2000 g. PA assays were performed on the supernatants.UK-type PA was evaluated by a liquid-phase assay in presence of human plasminogen (Kabi) and chromogenic substrate S 2251 (Kabi).tPA was determinated using a solid-phase fibrin activity assay which involves an affinity separation step and thus allows selective detection of tPA.In both cases, results were reported in international units by reference to standard curves of UK (Choay) or tPA (Kabi).In all cell types tested, PA detected was essentially urokinase-type. Highest PA activity was found in U 937 cells (0.7 IU/5×l06 cells). In normal blood lymphocytes, mean PA activity was 0.08 IU/5×l06 cells. Examination of lymphocytes from patients with CLL revealed a marked decrease in UK activity as compared to normals (< 0.01 IU/5×106 cells in more than 50 % cases).The function of PA in normal lymphocyte physiology and the potential pathogenic role of diminished PA in CLL lymphocytes remains to be investigated.

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Tarbell, T. D., D. S. Acton, and Z. A. Frank. "Phase Diversity Wavefront Sensing and Image Reconstruction on the MDI instrument at L1." In Adaptive Optics. Washington, D.C.: Optica Publishing Group, 1996. http://dx.doi.org/10.1364/adop.1996.awd.4.

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The Michelson Doppler Imager (MDI) is a spectral imaging experiment on the ESA-NASA Solar and Heliospheric Observatory spacecraft (SOHO-see Domingo et al., 1995). SOHO was launched in December, 1995, and reached its final orbit about the Earth-Sun Lagrangian point L1 in mid-February, 1996. This point, about 1.5×l06 km towards the Sun, is where the Earth’s and Sun’s gravity balance, allowing a nearly stable orbit ideal for continuous observations of the Sun and solar wind. MDI is collecting the observational data for the Solar Oscillations Investigation (SOI), a study of the interior structure of the Sun as inferred from the normal modes of oscillation seen on its surface (“heliosesmology”). Since launch, MDI has been collecting images showing the Doppler velocity, continuum intensity, and magnetic field on the solar surface with high spatial and temporal resolution. SOI/MDI were developed jointly by Stanford University and Lockheed Martin Advanced Technology Center, supported by NASA (see Scherrer et al., 1995). The Principal Investigator is Prof. P. Scherrer of Stanford.

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Badimon, L., J. J. Badimon, and V. Fuster. "ACUTE THROMBOSIS IN STENOTIC AREAS: IMPORTANCE OF THE VASCULAR MATRIX EXPOSED TO BLOOD." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642842.

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The platelet response to angioplasty or spontaneous plaque rupture leads to acute thrombotic occlusion under certain conditions. We analyzed the role of local shear rate (flow and vessel cross-section related), the nature of the exposed matrix and the effect of thrombin inhibition in platelet acute response to injury. Collagen type I (exposed in plaque rupture) and de-endothelialized pig aorta (mild injury) were exposed to pig blood in a tubular perfusion chamber with well characterized flow conditions, placed within an extracorporeal circuit in swine (N=20). Platelet deposition was measured by labeling autologous platelets with Indium and optical morphometry of epoxy embedded specimens. Selected specimens were analyzed by electron microscopy. Unanticoagulated blood and blood from animals treated with 300u/Kg of heparin were perfused over the substrate for 3 and 10 min at local shear rates typical of unobstructed arteries (212s™1 - 424s™1) and of stenotic vessel (824s™1 - 1690s™1). Platelet deposition (Platelets × 106/cm2 ± SE) for 3 min perfusions were:Platelet deposition is dependent on the reactivity of the vascular matrix exposed to blood and on the local shear rate. The greatest rate of thrombus growth is observed with collagen and high shear rate conditions which may precipitate acute thrombotic occlusion in stenotic regions, mainly when the coagulation pathway is not inhibited (255×l06 platelets/ cm2 in 3 minutes. The relative contribution of rheology and the isolated components of the atherosclerotic plaque matrix exposed to blood in the onset of acute coronary syndromes will be differentiated with this experimental model.

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Görög, P., J. D. Pearson, and V. V. Kakkar. "GENERATION OF REACTIVE OXYGEN METABOLITES BY PHAGOCYTOSING ENDOTHELIAL CELLS: REGULATORY ROLE OF THE GLYCOCALYX." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642862.

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We have studied the ability of particular stimuli to induce the release of reactive oxygen metabolites from sub-cultured monolayers of human umbilical vein endothelial cells. Superoxide production was measured as the superoxide dismutase-inhibitable reduction of exogenous cytochrome C, and H2O2 production was measured by the horseradish peroxidase catalysed oxidation of scopoletin. Basal release of either metabolite from undisturbed monolayers was low (80pmol O2 and 65pmol H2O2 in 3 h from dishes of 3×108 cells). Addition of 1μM diameter polystyrene microspheres (4.5×108 particles/dish) which were phagocytosed by the cells progressively over 3h, caused a dramatic increase in release of both metabolites (2nmol O2 and 490pmol H2O2 at 3h). Release of O2 was linear, whereas release of H2O2 was more rapid in the first hour. Addition of formaldehyde-fixed human platelets (2.5×l06/dish) significantly enhanced O2 production (490pmol at 2h) and raised, thought not significantly, H2O2 release (130pmol at 2h); addition of a stabilized lipid emulsion (lipofundin-S ; particle diameter 1μm, 3.6×108 particles/dish) caused a significant rise in O2 production (1.3nmol at 2h) but measurement of its effect on H2O2 release was prevented by interference in the assay. Similar rises in H2O2 and O2 production were induced by treatment with 10™7M phorbol myristate acetate. Pretreatment of endothelial cells with 12.5mU /ml neuraminidase or 0.5U/ml heparinase for 60 min to alter their glycocalyx composition substantially enhanced the effect of microspheres on H2O2 and O2 generation, particularly at early times (lh). We conclude that the interactions of particulates, including platelets and lipids, with endothelial cells can lead to the generation of significant pericellular levels of reactive oxygen species. These metabolites may oxidise a wide variety of nearby molecules, leading to cell damage and altered uptake characteristics for lipoproteins containing peroxidised lipids. These effects are exacerbated when endothelial cell glycocalyx composition is disrupted.

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Baker, J. B., M. P. McGrogan, C. Simonsen, R. L. Gronke, and B. W. Festoff. "STRUCTURE AND PROPERTIES OF PROTEASE NEXIN I." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644765.

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Human foreskin fibroblasts secrete several different serine protease inhibitors which differ in size and protease specificities. These proteins, called protease nexins (PNs) all form SDS-resistant complexes with their protease targets. Fibroblast surface receptors recognize the protease-PN complexes and mediate their delivery to lysosomes. PNI is a 45 kilodalton glycoprotein that rapidly inhibits several arg or lys-specific proteases including trypsin, thrombin, and urokinase (k assoc.∼ 4×l06,∼ 6×105 and ∼ 2×105, m−1s−1 respectively). Like antithrombin III, PNI binds heparin and inhibits thrombin at a vastly accelerated rate in the presence of this glycoaminoglycan. Immunofluorescence studies show that in addition to secreting PNI foreskin fibroblasts carry this inhibitor on their surfaces. PNI cDNA has been cloned and sequenced. A mixed oligonucleotide probe derived from PNI N-terminal sequence was used to probe a foreskin fibroblast cDNA library constructed with λGT10. Identification of PNI cDNAs has been verified by sequencing and by expressing active PNI protein in mammalian cells. The full amino acid sequence of PNI, deduced from cDNA sequencing, is 392 residues long and has 30% homology to antithrombin III. An arg-ser pair 32 residues from the C-terminus of the inhibitor is proposed as the reactive center P1-P1 residues. In the hinge region a lys residue is present in a position occupied by a ginor glu residue in other serpins. PNI mRNA exists in 2 slightly different forms:One (αPNI) yields a thr-arg-ser sequence wherethe other βPNI) yields a thr-thr-gly-ser sequence. The presence of the appropriate splice acceptor sites in the genome indicates that these forms are generated from a single gene by alternative splicing. Expressed aPNI and 0PNI proteins both bind thrombin and urokinase. In foreskin fibroblaststhe α form of PNI mRNA predominates over the β form by about 2:1. In foreskin fibroblast cultures secreted PNI inhibits the mitogenic response to thrombin and regulate secreted urokinase. Purified PNI added to human fibrosarcoma (HT1080) cells inhibitsthe tumor cell-mediated destruction of extracellular matrix and transiently, but dramatically, inhibits tumor cell growth. PNI or PNI-like inhibitors may function at multiple physiological sites. The β form of PNI is virtually identical to a glia-derived neurite promoting factor, the cDNA for which has been recently cloned and sequenced by Gloor et al (1). The neurite outgrowth activity of PNI may result from inhibition of a thrombin-like protease that is associated with neurons, since a number of thrombin inhibitors stimulate neurite extension. Recent immunofluoresence experiments, carried out with D. Hantai (Inserm; Paris) demonstrate that anti-PNI antibody intensely stains neuromuscular synapses. In addition, a PNI-like inhibitor is associated with platelets. At low (0.5 nM <) 125I-thrombin concentrations formation of 125I-thrombin-platelet PNI complexes accounts for most of the specific binding of 125I-thrombin to platelets (2). Although the platelet-associated form of PNI is electrophoretically and immunologically indistinguishable from fibroblast PNI, it does not bind urokinase, suggesting that it may be distinct.(1) Gloor, S., K. Odink, J. Guenther, H. Nick, and D. Monard. (1986) Cell 47:687-693.(2) Gronke, R.S., B.L. Bergman, and J.B. Baker. (1987) J. Biol. Chem. (in press)

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