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Добірка наукової літератури з теми "L-pgd"

Автор: Grafiati

Опубліковано: 11 березня 2023

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Статті в журналах з теми "L-pgd"

Hayaishi, Osamu. "Invited Review: Molecular genetic studies on sleep-wake regulation, with special emphasis on the prostaglandin D2 system." Journal of Applied Physiology 92, no. 2 (February 1, 2002): 863–68. http://dx.doi.org/10.1152/japplphysiol.00766.2001.

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To elucidate the exact role of the PGD2 system in sleep-wake regulation in vivo, the sleep behavior of knockout mice, generated in the author's and other laboratories, was examined for lipocalin-type PGD synthase (L-PGDS), PGD receptor, adenosine A2A receptor, and histamine H1 receptor; transgenic mice overexpressing the human L-PGDS gene, generated in the author's laboratory, were also examined. The circadian profiles of sleep patterns of wild-type and the genetically manipulated mice were essentially identical, indicating the possibility that the deficiency of one system may be effectively compensated by some other systems during development. Available evidence indicated that the PGD2 system is involved in the homeostatic regulation of non-rapid eye movement sleep and that the arousal effect of orexin A is mediated by the histamine H1receptor system.

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Souza, Rogério Fernandes de, and Eucleia Primo Betioli Contel. "Análise da variabilidade de isoenzimas em acessos e cultivares de girassol." Pesquisa Agropecuária Brasileira 36, no. 5 (May 2001): 771–79. http://dx.doi.org/10.1590/s0100-204x2001000500007.

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O número de genótipos de girassol (Helianthus annuus L.) disponíveis aos agricultores é pequeno e pouco se conhece sobre os genótipos provenientes de outros países que possam ser utilizados no melhoramento genético desta cultura. O objetivo deste trabalho foi analisar a variabilidade genética de 31 acessos e de cinco cultivares nos sistemas isoenzimáticos fosfoglicomutase (PGM), 6fosfogliconato desidrogenase (PGD), fosfoglicoisomerase (PGI) e esterase (EST). Utilizou-se a técnica de eletroforese em gel de amido/penetrose para o fracionamento das isoenzimas da PGM, PGI e PGD e focalização isoelétrica para EST. Foram detectados um total de seis locos e 14 alelos para estes quatro sistemas. Observou-se variantes alélicas para os locos Pgi2, Pgm1, Pgd2, cada um com dois alelos, e para Est1, que apresentou seis alelos. Os testes de adequação aos modelos de equilíbrio de Hardy-Weinberg e de Wright evidenciaram que em dez acessos houve um desvio significativo de endocruzamento.

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Fukuhara, Ayano, Mao Yamada, Ko Fujimori, Yuya Miyamoto, Toshihide Kusumoto, Hidemitsu Nakajima, and Takashi Inui. "Lipocalin-type prostaglandin D synthase protects against oxidative stress-induced neuronal cell death." Biochemical Journal 443, no. 1 (March 14, 2012): 75–84. http://dx.doi.org/10.1042/bj20111889.

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L-PGDS [lipocalin-type PGD (prostaglandin D) synthase] is a dual-functional protein, acting as a PGD2-producing enzyme and a lipid transporter. L-PGDS is a member of the lipocalin superfamily and can bind a wide variety of lipophilic molecules. In the present study we demonstrate the protective effect of L-PGDS on H2O2-induced apoptosis in neuroblastoma cell line SH-SY5Y. L-PGDS expression was increased in H2O2-treated neuronal cells, and the L-PGDS level was highly associated with H2O2-induced apoptosis, indicating that L-PGDS protected the neuronal cells against H2O2-mediated cell death. A cell viability assay revealed that L-PGDS protected against H2O2-induced cell death in a concentration-dependent manner. Furthermore, the titration of free thiols in H2O2-treated L-PGDS revealed that H2O2 reacted with the thiol of Cys65 of L-PGDS. The MALDI–TOF (matrix-assisted laser-desorption ionization–time-of-flight)-MS spectrum of H2O2-treated L-PGDS showed a 32 Da increase in the mass relative to that of the untreated protein, showing that the thiol was oxidized to sulfinic acid. The binding affinities of oxidized L-PGDS for lipophilic molecules were comparable with those of untreated L-PGDS. Taken together, these results demonstrate that L-PGDS protected against neuronal cell death by scavenging reactive oxygen species without losing its ligand-binding function. The novel function of L-PGDS could be useful for the suppression of oxidative stress-mediated neurodegenerative diseases.

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Yongsawas, Rujipas, Angkana Inta, Jatupol Kampuansai, Hataichanok Pandith, Nakarin Suwannarach, Saisamorn Lamyong, Panuwan Chantawannakul, Thararat Chitov, and Terd Disayathanoowat. "Bacterial Communities in Lanna Phak-Gard-Dong (Pickled Mustard Green) from Three Different Ethnolinguistic Groups in Northern Thailand." Biology 11, no. 1 (January 17, 2022): 150. http://dx.doi.org/10.3390/biology11010150.

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The Lanna region, the main part of northern Thailand, is a place of ethnic diversity. In this study, we investigated phak-gard-dong (PGD), or pickled mustard green (Brassica juncea L. Czern.), for its beneficial bacteria content and to analyse the variations in bacterial compositions among the PGD of three different ethnolinguistic groups, the Karen, Lawa, and Shan. DNA was extracted from the PGD pickled brine, and 16S rRNA gene Illumina sequencing was performed. Metagenomic data were analysed and the results demonstrated that the dominant bacterial species were Weissella (54.2%, 65.0%, and 10.0%) and Lactobacillus (17.5%, 5.6%, and 79.1%) in the PGD of the Karen, Lawa, and Shan, respectively. Pediococcus was found only in the PGD of the Karen and Shan. Bacterial communities in PGD of the Lawa were distinctive from the other ethnic groups, both in the alpha and beta diversity, as well as the predicted functions of the bacterial communities. In addition, overall network analysis results were correlated to bacterial proportions in every ethnic PGD. We suggest that all ethnic PGDs have the potential to be a good source of beneficial bacteria, warranting its conservation and further development into health food products.

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Howes, N. K., J. Chong, and P. D. Brown. "Oat endosperm proteins associated with resistance to stem rust of oats." Genome 35, no. 1 (February 1, 1992): 120–25. http://dx.doi.org/10.1139/g92-020.

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The presence of oat (Avena sativa L.) endosperm proteins, extracted with dimethylformamide mercaptoethanol – sodium dodecylsulfate and separated by dodecylsulfate polyacrylamide gel electrophoresis, was compared among cv. Rodney (carrying Pg4) and Rodney 0 derived backcross lines carrying single known genes Pg1, Pg2, Pg3, Pg8, Pg9, Pg13, Pg15, and Pg16, for stem rust resistance, and among other lines or cultivars with or without these genes. Most single-gene lines had polypeptide patterns similar to that of Rodney 0, a near-isogenic line with no known stem rust resistance. However, lines Rodney Pg3 and Rodney Pg9 were missing a 25.3-kDa avenin present in Rodney 0 and present in lines or cultivars that did not carry Pg9. The Rodney Pg13 line and several lines or cultivars that carried Pg13 were missing a 56.6-kDa polypeptide present in Rodney 0 and in several lines and cultivars that did not carry this gene. These results suggest that the Pg3/Pg9 and Pg13 loci were associated with the loci controlling the synthesis of the 25.3- and 56.6-kDa polypeptides, respectively. Results from genetic studies showed that gene Pg13 was linked in repulsion (linkage value 4.2 ± 1.9 cM) to the 56.6-kDa polypeptide locus.Key words: electrophoresis, oats, proteins, rust resistance.

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Long, Christopher M., Colleen A. Mulinix, and Amy F. Iezzoni. "Production of a Microspore-derived Callus Population from Sweet Cherry." HortScience 29, no. 11 (November 1994): 1346–48. http://dx.doi.org/10.21273/hortsci.29.11.1346.

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Microspore-derived callus cultures were obtained by anther culture of `Emperor Francis' sweet cherry (Prunus avium L.). Branches were removed from the field in January and March and forced in the laboratory. When the microspores reached the uninucleate stage, anthers were placed on modified Quoirin and Lepoivre liquid culture medium containing 4.4 μm BA and 4.5 μm 2,4-D. After ≈60 days, callus that emerged from the anthers was placed on woody plant medium supplemented with 1 μm 2,4-D and 3 μm 2iP and routinely transferred. The resulting 270 callus cultures were screened for two allozymes heterozygous in `Emperor Francis', Pgi-2 and 6-Pgd-1. Of the 270 callus cultures, 154 expressed only one allele each for Pgi-2 and 6-Pgd-1; thus, they were considered microspore-derived. The microspore-derived callus cultures can be used as a linkage mapping population. Chemical names used: 6-benzyladenine (BA); 2,4-dichlorophenoxyacetic acid (2,4-D); N6-(2-isopentenyl)-adenine (2iP).

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Chaparro, J. X., R. E. Durham, G. A. Moore, and W. B. Sherman. "Use of Isozyme Techniques to Identify Peach x ‘Nonpareil’ Almond Hybrids." HortScience 22, no. 2 (April 1987): 300–302. http://dx.doi.org/10.21273/hortsci.22.2.300.

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Abstract Two isozyme systems, phosphoglucomutase (PGM) and 6-phosphogluconate dehydrogenase (PGD), were identified that permit the early verification of peach x almond hybrids as opposed to plants resulting from accidental self-pollination. Nondestructive samples for analysis can be taken from cotyledons or primary leaves. Isozymes of PGM-2, PGD-1, and PGD-2 were found to be monomorphic in the peach [Prunus persica (L.) Batsch] cultivars studied. P. amygdalus Batsch ‘Nonpareil’ was found to be heterozygous at the PGM-2 banding region, bearing the peach allele and a slower migrating allele. This locus allows verification of 50% of the hybrids. ‘Nonpareil’ was homozygous for alleles contrasting to peach at the PGD-1 and PGD-2 banding regions, allowing the unequivocal verification of all hybrids.

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Sun, Mei, and Jan Dvořák. "Chromosomal location of adenylate kinase, 6-phosphogluconate dehydrogenase, and glutamate-pyruvate transaminase structural loci in wheat, barley, and Lophopyrum elongatum." Genome 35, no. 1 (February 1, 1992): 147–54. http://dx.doi.org/10.1139/g92-024.

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The chromosome locations of loci encoding isozymes of adenylate kinase, EC 2.7.4.3 (ADK), 6-phosphogluconate dehydrogenase, EC 1.1.1.44 (PGD), and glutamate–pyruvate transaminase, EC 2.6.1.2 (GPT) were investigated in wheat (Triticum aestivum L.), Lophopyrum elongatum (Host) Löve, and barley (Hordeum vulgare L.). Loci encoding ADK-1 are on homoeologous chromosome arms 7AL, 7BL, and 7DL in wheat, chromosome arm 7Eβ in L. elongatum, and chromosome arm 7HS in barley. The loci are designated Adk-A1, Adk-B1, Adk-D1, Adk-E1, and Adk-H1, respectively. The Adk-D1 locus is proximal in the linkage group of chromosome arm 7DL and is 24 cM from proximal locus Rc3 on the chromosome arm 7DS. A second locus, Adk-2, is on chromosome arm 6HL in barley. Locus Pgd-E2 in L. elongatum is on the long arm of chromosome 1E. This assignment agrees with the location of the barley Pgd-2 locus on the long arm of barley chromosome 1H. An attempt to assign loci encoding PGD-2 to wheat chromosomes was unsuccessful, presumably owing to gene triplication. Isozyme GPT-1 is encoded by structural genes on L. elongatum chromosome arm 1ES and tentatively on wheat chromosome arms 1AS, 1BS, and 1DS. The loci are designated Gpt-A1, Gpt-B1, Gpt-D1, and Gpt-E1, respectively. Circumstantial evidence suggests that GPT-1 is also encoded by barley chromosome 1H.Key words: Triticum, Agropyron, Hordeum, linkage.

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Melegos, D. N., E. P. Diamandis, H. Oda, Y. Urade, and O. Hayaishi. "Immunofluorometric assay of prostaglandin D synthase in human tissue extracts and fluids." Clinical Chemistry 42, no. 12 (December 1, 1996): 1984–91. http://dx.doi.org/10.1093/clinchem/42.12.1984.

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Abstract A two-site sandwich-type assay for human prostaglandin D (PGD) synthase (beta-trace) was developed with two monoclonal antibodies and using time-resolved fluorometry as the detection technique. The assay is precise (CVs < 10%), accurate, and highly specific for PGD synthase and has a detection limit of 0.05 microgram/L. Using this assay, we measured PGD synthase concentrations in serum, urine, amniotic fluid, cerebrospinal fluid (CSF), seminal plasma, breast cyst fluid, breast discharge fluid, breast milk, and breast tumor extracts. The highest concentrations were found in CSF. We identified proteolytic degradation of PGD synthase in amniotic fluid. Fetal tissues contained various amounts of the enzyme, with the highest values being found in brain and heart. In placental extracts, PGD synthase content was greatest at 11-28 weeks of gestation-in accordance with the concentrations measured in amniotic fluids for this gestational period. We conclude that PGD synthase is ubiquitous and is present in many fluids and tissues of adults and fetuses. This first quantitative and sensitive assay of PGD synthase should facilitate expansion of knowledge on this enzyme and possibly will have applications for diagnosis and monitoring of human diseases.

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Corts, Remedios Morales, Luciano Cordeiro Rodrigues, Jesús Maria Ortíz Marcide, and Rodrigo Pérez Sánches. "Characterization of sour (Prunus cerasus L.) and sweet cherry (Prunus avium L.) varieties with five isozyme systems." Revista Brasileira de Fruticultura 30, no. 1 (March 2008): 154–58. http://dx.doi.org/10.1590/s0100-29452008000100028.

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Extracts from young leaves of nine sweet cherry (Prunus avium L.) and eight sour cherry (Prunus cerasus L.) varieties, located in the germplasm collection of the 'Direção Regional de Agricultura da Beira Interior' (Fundão, Portugal), were analysed for five isozyme systems in order to characterise these varieties and detect problems of synonymies and homonymies that frequently present. The sweet and sour cherry varieties analyzed showed low isoenzymatic polymorphism, being PGM and PGI the systems with the highest discrimination power. These systems presented seven and five different zymogrames, respectively. IDH showed four patterns. SKDH and 6-PGD grouped the varieties only into two patterns. The evident and discriminant restrictions of this type of analysis had got results that have only been a complement for agronomical and morphological characterization.

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Більше джерел

Дисертації з теми "L-pgd"

Vitse, Matthieu. "Réduction de modèle pour l'analyse paramétrique de l'endommagement dans les structures en béton armé." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLN055/document.

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Ces travaux de thèse sont consacrés au développement d'un algorithme de résolution de problèmes non-linéaires pour lesquels il existe une variabilité sur certains paramètres du modèle ou du chargement définis par leur intervalle de définition. Le cadre d'étude est le projet SINAPS@, qui a pour but d'évaluer les incertitudes dans les structures de génie civil, et de quantifier leur influence sur la réponse mécanique globale d’une structure sujette à un aléa sismique. Contrairement aux approches statistiques ou probabilistes classiques, une résolution déterministique est privilégiée dans notre étude. Cependant, afin de réduire le coût de calcul de cette famille de problèmes, une approche de type réduction de modèle PGD est mise en place, pour laquelle les paramètres incertains sont considérés comme des variables supplémentaires du problème. Cette méthode est mise en place au sein de l'algorithme LATIN, qui utilise une approche itérative pour résoudre le caractère non-linéaire des équations rencontrées lors de la résolution du problème mécanique. Ces travaux présentent donc l'extension de l'algorithme classique temps-espace LATIN-PGD à des problèmes paramétriques, pour lesquels les paramètres sont considérés comme des variables additionnelles dans la définition des quantités d’intérêt, ainsi que l'application de cette méthode à un modèle endommageant avec refermeture de fissure, présentant une variabilité à la fois sur des paramètres matériaux et sur l'amplitude du chargement. La faisabilité de ce couplage est illustrée par des exemples numériques sur des structures en béton armé pour divers types de chargement cycliques (traction—compression, flexion)
This thesis is dedicated to the development of an algorithm for the resolution of nonlinear problems for which there is a variability on some of the model parameters or on the loading conditions, which are only described by their intervals of variation. This study is part of the SINAPS@ project, which aims at evaluating the uncertainties in civil engineering structures and to quantify their influence on the global mechanical response of a structure to a seismic hazard. Unlike statistical or probabilistic approaches, we rely here on a deterministic approach. However, in order to reduce the computation cost of such problems, a PGD-based reduced-order modeling approach is implemented, for which the uncertain parameters are considered as additional variables of the problem. This method was implemented into the LATIN algorithm, which uses an iterative approach to solve the nonlinear aspect of the equations of the mechanical problem. This work present the extension of the classical time-space LATIN—PGD algorithm to parametric problems for which the parameters are considered as additional variables in the definition of the quantities of interest, as well as the application of such method to a damage model with unilateral effect, highlighting a variability on both material parameters and the loading amplitude. The feasibility of such coupling is illustrated on numerical examples for reinforced concrete structures subjected to different types of cyclic loading conditions (tension—compression, bending)

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Mathurin, Karine. "L'arrestine-3 régule la production de PGD2 médiée par la L-PGDS." Mémoire, Université de Sherbrooke, 2010. http://savoirs.usherbrooke.ca/handle/11143/5324.

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Les prostaglandines (PGs) sont des médiateurs lipidiques impliqués dans une multitude de processus physiologiques, tels que le sommeil et l'équilibre osseux, mais également dans des phénomènes pathologiques comme l'inflammation chronique et le cancer. Les PGs sont produites à partir de l'acide arachidonique par l'action des cyclooxygénases (COXs) et des PGs synthétases. La régulation de ces dernières est très mal comprise par la communauté scientifique. La L-PGDS est la principale synthétase qui produit la PGD 2 , une PG impliquée entre autres dans la nociception, l'asthme, l'athérosclérose et les allergies. Un criblage par double hybride effectué avec l'arrestine-3 (Arr3) a permis d'identifier la L-PGDS comme partenaire d'interaction. Les arrestines non visuelles sont connues pour leurs rôles dans la désensibilisation et l'endocytose des récepteurs couplés aux protéines G (RCPGs). Cependant, au fil des ans, plusieurs partenaires d'interaction de ces protéines ont été identifiés et ont permis de leur découvrir de nouvelles fonctions. Nous en sommes donc venus à penser que ces protéines multifonctionnelles pourraient réguler la L-PGDS en interagissant avec celle-ci. L'interaction a été confirmée par des essais GST-Pulldown, et de co-immunoprécipitation, dans des systèmes transfecté et endogène dans la lignée ostéoblastique MG-63. La microscopie confocale suggère que la modulation de l'activité enzymatique de la L-PGDS semble modifier la localisation cellulaire des protéines Arr3 et L-PGDS. Des dosages de PGD 2 indiquent que la présence d'Arr3 dans des essais de production de PGD2 in vitro augmente la production de PGD2 , tandis que les fibroblastes embryonnaires de souris (MEFs) déficientes pour les arrestines produisent moins de PGD 2 que les MEFs de type sauvage suite à une stimulation à la PGH2 , ainsi qu'avec l'IL-1?. Cette diminution de production est renversée par la transfection d'arrestines. Un peptide comprenant la région en acides aminés 86 à 100 sur l'Arr3 est suffisant pour augmenter les niveaux de PGD 2 observés in vitro et in cellulo dans les MG-63. Dès lors, nos études identifient pour la première fois un partenaire d'interaction pour la L-PGDS, l'Arr3, qui régule la production de PGD2 . De plus, un peptide comprenant la région d'interaction de l'Arr3 sur la L-PGDS est suffisant pour augmenter la production de PGD2 . Cette nouvelle approche pourrait être utilisée afin de synthétiser des peptides mimétiques spécifiques à la PGD2 dans un traitement anti-inflammatoire alternatif aux inhibiteurs des COXs

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Bhattacharyya, Mainak. "A model reduction approach in space and time for fatigue damage simulation." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLN019/document.

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L'objet de ce projet de recherche est de prédire la durée de vie d'éléments mécaniques qui sont soumis à des phénomènes de fatigue cyclique. L'idée est de développer un schéma numérique novateur pour prédire la rupture de structures sous de tels chargements. Le modèle est basé sur la mécanique des milieux continus qui introduit des variables internes pour décrire l'évolution de l'endommagement. Le défi repose dans le traitement des cycles de chargement pour la prédiction de la durée de vie, particulièrement pour la prédiction de la durée de vie résiduelle de structures existantes. Les approches traditionnelles de l'analyse de la fatigue sont basées sur des méthodes phénoménologiques utilisant des relations empiriques. De telles méthodes considèrent des approximations simplificatrices et sont incapables de prendre en compte aisément des géométries ou des charges complexes associées à des problèmes d'ingénierie réels. Une approche basée sur la description de l'évolution thermodynamique d'un milieu continu est donc utilisée pour modéliser le comportement en fatigue. Cela permet de considérer efficacement des problèmes d'ingénierie complexe et la détérioration des propriétés du matériau due à la fatigue peut être quantifiée à l'aide de variables internes. Cependant, cette approche peut être numériquement coûteuse et, par conséquent, des approches numériques sophistiquées doivent être utilisées.La stratégie numérique sur laquelle ce projet est basé est singulière par rapport aux schémas incrémentaux en temps usuellement utilisés pour résoudre des problèmes élasto-(visco)plastique avec endommagement dans le cadre de la mécanique des milieux continus. Cette stratégie numérique appelée méthode LATIN (Large Time Increment method) est une méthode non-incrémentale qui recherche la solution de manière itérative sur l'ensemble du domaine spacio-temporel. Une importante innovation de la méthode LATIN est d'incorporer une stratégie de réduction de modèle adaptative pour réduire de manière très importante le coût numérique. La Décomposition Propre Généralisée (PGD) est une stratégie de réduction de modèle a priori qui sépare les quantités d'intérêt spacio-temporelles en deux composantes indépendantes, l'une dépendant du temps, l'autre de l'espace, et estime itérativement les approximations de ces deux composantes. L'utilisation de l'approche LATIN-PGD a montré son efficacité depuis des années pour résoudre des problèmes élasto-(visco)plastiques. La première partie de ce projet vise à étendre cette approche aux modèles incorporant de l'endommagement.Bien que l'utilisation de la PGD réduise les coûts numériques, le gain n'est pas suffisant pour permettre de résoudre des problèmes considérant un grand nombre de cycles de chargement, le temps de calcul peut être très conséquent, rendant les simulations de problèmes de fatigue intraitables même en utilisant les techniques LATIN-PGD. Cette limite peut être dépassée en introduisant une approche multi-échelle en temps, qui prend en compte l'évolution rapide des quantités d'intérêt lors d'un cycle et leur évolution lente au cours de l'ensemble des cycles. Une description type « éléments finis » en temps est proposée, où l'ensemble du domaine temporel est discrétisé en éléments temporels, et seulement les cycles nodaux, qui forment les limites des éléments, sont calculés en utilisant la technique LATIN-PGD. Puis, des fonctions de forme classiques sont utilisées pour interpoler les quantités d'intérêt à l'intérieur des éléments temporels. Cette stratégie LATIN-PGD à deux échelles permet de réduire le coût numérique de manière significative, et peut être utilisée pour simuler l'évolution de l'endommagement dans une structure soumise à un chargement de fatigue comportant un très grand nombre de cycles
The motivation of the research project is to predict the life time of mechanical components that are subjected to cyclic fatigue phenomena. The idea herein is to develop an innovative numerical scheme to predict failure of structures under such loading. The model is based on classical continuum damage mechanics introducing internal variables which describe the damage evolution. The challenge lies in the treatment of large number of load cycles for the life time prediction, particularly the residual life time for existing structures.Traditional approaches for fatigue analysis are based on phenomenological methods and deal with the usage of empirical relations. Such methods consider simplistic approximations and are unable to take into account complex geometries, and complicated loadings which occur in real-life engineering problems. A thermodynamically consistent continuum-based approach is therefore used for modelling the fatigue behaviour. This allows to consider complicated geometries and loads quite efficiently and the deterioration of the material properties due to fatigue can be quantified using internal variables. However, this approach can be computationally expensive and hence sophisticated numerical frameworks should be used.The numerical strategy used in this project is different when compared to regular time incremental schemes used for solving elasto-(visco)plastic-damage problems in continuum framework. This numerical strategy is called Large Time Increment (LATIN) method, which is a non-incremental method and builds the solution iteratively for the complete space-time domain. An important feature of the LATIN method is to incorporate an on-the-fly model reduction strategy to reduce drastically the numerical cost. Proper generalised decomposition (PGD), being a priori a model reduction strategy, separates the quantities of interest with respect to space and time, and computes iteratively the spatial and temporal approximations. LATIN-PGD framework has been effectively used over the years to solve elasto-(visco)plastic problems. Herein, the first effort is to solve continuum damage problems using LATIN-PGD techniques. Although, usage of PGD reduces the numerical cost, the benefit is not enough to solve problems involving large number of load cycles and computational time can be severely high, making simulations of fatigue problems infeasible. This can be overcome by using a multi-time scale approach, that takes into account the rapid evolution of the quantities of interest within a load cycle and their slow evolution along the load cycles. A finite element like description with respect to time is proposed, where the whole time domain is discretised into time elements, and only the nodal cycles, which form the boundary of the time elements, are calculated using LATIN-PGD technique. Thereby, classical shape functions are used to interpolate within the time element. This two-scale LATIN-PGD strategy enables the reduction of the computational cost remarkably, and can be used to simulate damage evolution in a structure under fatigue loading for a very large number of cycles

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Yeni, Filiz. "Determination Of Polymorphism Of Pgm, Hk, Pgi, And G6pd In Different Developmental Stages Of Honey Bee (apis Mellifera L.) And Its Relation With Pgm Activity And Glycogen Content." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/2/12611930/index.pdf.

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In this study, three subspecies of Apis mellifera L. (A. m. caucasica, A. m. carnica, and A. m. syriaca) from different climatic regions were evaluated electrophoretically at ontogenetic level by means of four enzymes, namely Phosphoglucomutase (PGM), Hexokinase (HK), Phosphoglucose isomerase (PGI) and Glukose-6-phosphate dehydrogenase (G6PD). It is determined that only Pgm and Hk loci were polymorphic. Allele and genotype frequencies at Pgm locus changes seasonally whereas Hk locus does not exhibit seasonal variation. Within the scope of this study we investigated at which developmental stage shifting to heterozygotes prior to winter occurs. It is found that there is a seasonal fluctuation throughout the year in Pgm genotype frequencies at each developmental stage studied and correlated with enzyme activity and glycogen content. As the studied enzymes have crucial v roles in insect energy metabolism, results of this study provided further information about the relationship between carbohydrate metabolism and enzyme polymorphism of honey bees.

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McDonald, D. P. "Genetics, physiology and biochemistry of the PGI polymorphism in Asellus aquaticus (L.)." Thesis, University of Essex, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328752.

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Quesada, López Enrique M. "Mecacci. L. (1985). Radiografía del cerebro. Barcelona: Ariel. trad. del italiano. 174 pgs." Pontificia Universidad Católica del Perú, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/102520.

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Gulduren, Zerrin. "Causes And Consequences Of Seasonal Variation Of Phosphoglucomutase (pgm) Enzyme Polymorphism In Honeybees, (apis Mellifera L.) Of Turkey." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609357/index.pdf.

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Phosphoglucomutase (PGM) is one of the central enzymes in energy metabolism at a branch point at the head of the metabolic pathway leading into glycogen metabolism, pentose shunt and the main glycolytic cycle, catalyzing the reversible interconversion of glucose-1-phosphate to glucose-6-phosphate. Whole year, month to month analysis of pattern of allozyme variation at Pgm and Hk loci in Apis mellifera L. from three provinces
Kirklareli, Artvin, and Hatay revealed that there is significant seasonal variation of allozyme frequencies at Pgm locus (P<
0.001). The difference in genotype frequencies between summer and winter samples is apparent in Pgm, whereas at Hk locus, which is analyzed as a control there is seasonal variation in genotype frequencies. Biochemical measurements of the enzyme activities and glycogen content of different Pgm genotypes were performed to determine the effect of different Pgm genotypes on the physiological performance of the honeybees and it was observed that both enzyme activity and glycogen amount is higher in heterozygote individuals which are in high frequency during winter months (P<
0.0001). Furthermore, PGM enzyme activity and glycogen content was found to be significantly correlated. These findings clearly demonstrate that biochemical differences between different Pgm genotypes have functional correlates that lead to significant variations in glycogen content of the honeybees and may have adaptive consequences.

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Doke, Mehmet Ali. "Analysis Of Environmental Cues Causing The Seasonal Change In Pgm (phosphoglucomutase) Allozyme Frequencies In Honeybees (apis Mellifera L.)." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12615187/index.pdf.

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In an earlier project completed in our laboratory a seasonal fluctuation in Phosphoglucomutase (PGM) phenotype frequencies was found, so that the winter bees were almost all heterozygotes and long lived than the summer bees among which homozygotes were significantly at high frequencies at Pgm locus. Same results were obtained in populations of three subspecies, A. m. meda, A. m. caucasica, and A. m. carnica from different climatic regions. In the current study environmental cues related with seasonal change in PGM phenotype frequency was examined along with the correlation between PGM heterozygosity and overwintering success. Cessation of food influx was found to be effective by itself as an environmental cue that causes a sudden and sharp increase in PGM heterozygosity. In addition to that, PGM heterozygosity of the colonies with greater overwintering success was found to be significantly higher than the ones with intermediate or low overwintering success. Benefiting from the previous studies and the results of current study, ethyl oleate was suggested as a chemical signal that functions in the regulation of PGM heterozygosity.

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Jabraoui, Siham. "L' intégration organisationnelle des PGI et la démarche stratégique des entreprises industrielles: étude des configurations et des dynamiques." Versailles-St Quentin en Yvelines, 2011. http://www.theses.fr/2011VERS004S.

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Ce que l’on appelle l’« implémentation » des progiciels de gestion intégrés (PGI), conduit généralement à une refonte du système d’information de gestion, et à une remise à plat des procédures de gestion en place, lesquelles peuvent être par la suite réorganisées suivant les orientations stratégiques ciblées par l’entreprise. Les principaux problèmes commencent lorsqu’il s’agit d’intégrer les fonctionnalités spécifiques à chaque entreprise dans le PGI. Entre la standardisation des processus de gestion et la personnalisation du PGI, les entreprises semblent être souvent en quête d’un équilibre qui reflète la cohérence de leurs choix et de leurs décisions avec leurs orientations stratégiques. C’est sur ce thème de la recherche d’équilibre que notre thèse se positionne. Elle vise dans ce cadre à explorer les différents choix stratégiques effectués par les entreprises pour intégrer un PGI. C’est sur la base de ces choix que nous avons tenté de décrypter les différentes modalités adoptées pour intégrer ces progiciels, à partir d’une enquête qualitative par entretiens semi-directifs auprès de 16 entreprises industrielles. Il en est sorti trois configurations de base construites au niveau local des entités concernées par l’intégration, et une quatrième configuration dite "mixte" qualifiant la synergie de l’ensemble des configurations adoptées à l’échelle globale de l’entreprise. L’analyse de l’évolution de ces modalités dans le temps est une question qui s’est révélée indispensable, dans la mesure où elle permet de prendre en compte le caractère ouvert et dynamique des processus d’intégration organisationnelle des PGI
What is called « implementation » of Enterprise Resource Planning (ERP) usually leads to a rebuilding of management information systems, and to a revisit of management procedures that can be thereafter reorganized according to the company’s strategic orientations. The main problems start when one wants to integrate specific functionalities of a particular company into the ERP. Between the standardization of management procedures and the personalization of ERP, companies often seem to look for a balance that reflects the coherence of their choices and decisions according to their strategic orientations. It’s this topic of balance which constitutes the heart of this dissertation. This research aims to explore the various strategic choices done by companies to integrate ERP. It’s on the basis of these choices that we have tried to decrypt the different modalities adopted to integrate these softwares. We have found three basic configurations built on local levels of the entities concerned by the integration, and a fourth mixed configuration qualifying the synergy of the overall configurations adopted to the wider level of the company. The analysis of the longitudinal evolution of these modalities is a question that appeared to be directly related to the basic problem, because it allows to take into consideration the opened and dynamic behavior of integration processes

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Santos, Ana Rita Basílio. "Medicago truncatula as a platform for Molecular Farming: a study of the subcellular localization of a human recombinant protein!" Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/10253.

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Dissertation presented at Faculdade de Ciências e Tecnologia of Universidade Nova de Lisboa to obtain the Degree of Master in Biotecnology
The use of transgenic plants for the production of recombinant proteins with commercial and pharmaceutical value offers several advantages when compared to the standard systems. Whole plant systems have potential for studies of the recombinant protein trafficking and suspension cell cultures combine the advantages of plants with the benefits of protein production by cell cultures. In this master thesis work, Medicago truncatula plants expressing a lipocalin-type human prostaglandin D2 synthase (L-PGDS) were used and the protein trafficking was studied. This study was the first analysis of the production of this protein in this specific plant and the first study of the subcellular trafficking of this protein in plants. Two production systems were analyzed: whole-plant systems and suspension cell cultures. The presence of the L-PGDS was studied in three different plant organs (leaf, root and seed) and in the cells and cell medium, by Western Blotting and fluorescence and electron microscopy. The L-PGDS protein appeared to accumulate in different places and patterns depending on which type of cell it is being produced. Recent work has shown that functional specialization of plant cells in storage organs can influence the subcellular trafficking of recombinant proteins, so the protein subcellular fate could be different between seeds and leaves of the same transformed plant. It has also been demonstrated that the plant species where the recombinant protein is produced, can alter the trafficking parameters. Medicago truncatula is, thus, a promising system for the production of recombinant proteins. The initial results obtained in this study could contribute to future studies and development in Molecular Farming.

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S, Greenberg Bradley, Rampoldi Hnilo Lynn A, and Mastro Dana, eds. The alphabet soup of television rating programs : (Y-G-PG-V-S-D-14-FV-MA-7-L). Cresskill, N.J: Hampton Press, 2001.

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Bkmk-Pge Mrk-Jesus L. Bob Siemon Designs, 1990.

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Частини книг з теми "L-pgd"

Aloo, Becky Nancy, Ernest Rashid Mbega, and Billy Amendi Makumba. "Sustainable Food Production Systems for Climate Change Mitigation: Indigenous Rhizobacteria for Potato Bio-fertilization in Tanzania." In African Handbook of Climate Change Adaptation, 1–27. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-42091-8_276-1.

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AbstractThe global rise in human population has led to the intensification of agricultural activities to meet the ever-rising food demand. The potato (Solanum tuberosum L.) is a crop with the potential to tackle food security issues in developing countries due to its short growth cycle and high nutrient value. However, its cultivation is heavily dependent on artificial fertilizers for yield maximization which culminates in global warming and other environmental problems. There is need, therefore, for its alternative fertilization technologies to mitigate climate change. This study evaluated the potential of indigenous rhizobacteria for potato cropping in Tanzania. Ten potato rhizobacterial isolates belonging to Enterobacter, Klebsiella, Citrobacter, Serratia, and Enterobacter genera were obtained from a previous collection from different agro-ecological areas in Tanzania. The isolates were characterized culturally, microscopically, biochemically, and by their carbohydrate utilization patterns. Their in vitro plant growth-promoting (PGP) traits such as nitrogen fixation, solubilization of phosphates, potassium, and zinc, and production of siderophores, indole acetic acid, and gibberellic acids were then evaluated. Lastly, sterilized potato seed tubers were bacterized with the inoculants and grown in pots of sterile soil in a screen-house using untreated plants as a control experiment. The potato rhizobacterial isolates had varying characteristics and showed varying in vitro PGP activities. The screen-house experiment also showed that the rhizobacterial treatments significantly (p < 0.05) enhanced different parameters associated with potato growth by up to 91% and established the potential of most of the isolates as alternative biofertilizers in potato cropping systems in Tanzania.

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Aloo, Becky Nancy, Ernest Rashid Mbega, and Billy Amendi Makumba. "Sustainable Food Production Systems for Climate Change Mitigation: Indigenous Rhizobacteria for Potato Bio-fertilization in Tanzania." In African Handbook of Climate Change Adaptation, 1469–95. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-45106-6_276.

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Fernanda Romo-García, Maria, Martín Zapata-Zuñiga, José Antonio Enciso-Moreno, and Julio Enrique Castañeda-Delgado. "The Role of Estrogens in Rheumatoid Arthritis Physiopathology." In Rheumatoid Arthritis - Other Perspectives towards a Better Practice. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.93371.

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Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease that can lead to irreversible disability. It affects women in a higher proportion than men (3:1 cases). Several reports suggest a link between female sexual hormones (estrogens) and RA features. It’s been described that biological processes where basal estrogen levels are altered like in menstruation, pregnancy, and menopause modifies RA onset, flare, disease severity, and inflammation. Estrogens have a direct action upon the immune system though ERα and ERβ receptors, which have distinct affinity to estrogen concentrations and modifications and have effects upon RA in a dose and receptor dependent manner. The studies focused on dose dependent response at experimental settings reveal a wide (from 25 pg/L to several μg/L) and even contradictory spectrum of effects in patients and cells. This chapter summarizes the contributions and effects of estrogens in RA physiopathology, clinical features, and discusses the possible contributions of estrogen administration and concentration of hormone replacement therapy (HRT) to improve the quality of life and reduce the symptoms of RA patients based on the knowledge of the biology of these hormones.

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Kumar, Neeraj. "Progressive Imbalance and Visual Impairment in a Patient With Diabetes." In Mayo Clinic Cases in Neuroimmunology, edited by Andrew McKeon, B. Mark Keegan, and W. Oliver Tobin, 248–50. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197583425.003.0081.

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A 72-year-old man with hypothyroidism and type 2 diabetes sought care for a 3-year history of slowly progressive, ascending lower limb paresthesias and imbalance. Three months earlier, he noted subacute onset of finger numbness and substantial worsening of imbalance with infrequent falls. He also had a 1-year history of progressive visual decline that persisted despite cataract surgery. Additional symptoms included intermittent light-headedness and confusion. Laboratory evaluations showed a decreased hemoglobin value and an increased mean corpuscular volume. Macrocytic red blood cells were noted on a peripheral blood smear. Serum vitamin B₁₂ level was less than 70 ng/L. Levels of plasma homocysteine and serum methylmalonic acid were markedly increased to 375 µmol/L and 143 nmol/L, respectively. Serum copper level was normal. Serum parietal cell antibodies were increased to 46 U, and intrinsic factor antibodies were absent. Serum gastrin was markedly increased. The clinical presentation in this patient suggested a myeloneuropathy. His vitamin B₁₂ level was undetectable and accompanied by a macrocytic anemia and increased methylmalonic acid and homocysteine levels. Even though intrinsic factor antibodies were negative, the clinical picture was supportive of subacute combined degeneration in the setting of pernicious anemia. The patient was started on vitamin B₁₂ replacement. At 6-month follow-up he had striking improvement in gait and vision. The light-headedness and confusion were no longer present. His examination was remarkable only for mild impairment, with tandem gait and a slightly positive Romberg sign. The lower limb reflexes were reduced. Impaired position perception at the toes persisted, but vibration perception in the lower limbs improved. Laboratory investigations showed normalization of the hemoglobin, vitamin B₁₂, methylmalonic acid, and homocysteine levels. The serum gastrin level had improved but was still increased at 742 pg/mL. The best-characterized neurologic manifestations of vitamin B₁₂ deficiency include myelopathy and myeloneuropathy. Autonomic neuropathy, optic neuropathy, and neuropsychiatric manifestations have also been reported. Neurologic manifestations may occur without evidence of the characteristic hematologic derangement, megaloblastic anemia. Macrocytosis or hypersegmented neutrophils on peripheral blood smear may be clues.

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Clamont, M. G. Ramos, A. A. Gardea, L. Vázquez-Moreno, I. Vargas-Arispuro, and M. A. Martínez-Téllez. "Effect of Low Temperatures Over PG Activity and Firmness in Zucchini Squash ( Cucurbita pepo L)." In Agri-Food Quality II, 182–84. Elsevier, 1999. http://dx.doi.org/10.1533/9781845698140.4.182.

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McMickle, Peter L., and Paul H. Jensen. "1820. L [Israel] Alger. The young merchant’s manual, or practical book-keeper … Boston: Printed for the author. [48] pgs. (Various paging) 32.5 cm NUC NA0168009." In The Birth of American Accountancy, 219–22. Routledge, 2020. http://dx.doi.org/10.4324/9781003082095-32.

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McMickle, Peter L., and Paul H. Jensen. "1794 Richard Turner. A new introductionto book keeping … First American Edition. Boston: Printed by L Thomas and E. T. Andrews. 24 [3] [17] [3] pgs. (various pagings) 16 cm. Evans 27824 NUC NT0397210." In The Birth of American Accountancy, 81–96. Routledge, 2020. http://dx.doi.org/10.4324/9781003082095-8.

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"a (o m ft oeunnti ) n an cdom th p e arison to som inten duration of tehenodrrmyaplero io r d. avTeh ra ugse , b cu y l ti a v lt aetr io in ngprtahcet ic cerso . p, genotype, planting date, and m th u es sesid ty ef iann it d io ndsu . raM ti eotneoarroelotghieca key characteristics of Agriculture is usually the first economic sector to phe t be considered as region spe lcid fi rcosuignh ce ttdheefiantim tio onss abreeao ff f e te c n te dqub ic ykd ly roduegph le ttbeedc , aeusspeec so ia illlymiofis th tu erepesruipopdl ie osftsaotm io ric cendaoerfen diti ini c ti l o im on astethraetgriemseu lt dienpe deficiencies of precipi moisture deficiency is associated with high tempera on the ns differentiate me n te doernotl . ogFiocraledxraomupglhet , tduurreisngan th dewgirnodwyincgon se d a it sioonnsi . s T cr h it e ic a ti l m in in tgheofdertaeirnm fa i l llm es asgn th abna si ssom of e th sepencu if m ie bderthorfesdhao ys l with precipitation nation of impacts. Crop or forage yields may be nor (e.g., itude of the deficiency over so dmreap th e e ri rod th o an f ti t m he etm im al eloyr ( i a .e b . o , vceo in ncoirdm in aglwdiu th ri n cr g i ti acadlrpohueg no hltog if icraalinsfta ag ll esi ) saOsrm ga unc fo h r Britain, fifteen days, none of which received and effective (i.e., low intensity and high soil infil in thos iz aeats0. rieogni215 on 93m6m ]) . oSfupcrh ec a ip idteaftiinoint io [B n ri is ti suhnrReaailn is ftailcl trat H io yndrroaltoeg ). ical droughts are associated with the effects c se oam so mno al n . an M d os etxst where precipitation distributi m en e d te eodropleorg io ic daslw dr i o th uoguhttrd ai enff in al oln is of periods of precipitation shortfall on surface or sub relate actual precipitation depa itio a n re slsaukre fa cleevw els a , tegr ro su upnpdlwya ( tie .e r) ., rsa tr th ea emrftlhoawn , rweistehrvpor ir eca ip nid a ti mmoeun sc tasleosn . H monthly, seasonal, wa rtteurreyse ar t , ooraavnen ra ugaeltHay ti dornolsohgo ic rt aflald ls r o ( uDgrhatcsuapreetusaul. al1 ly 98o0u , t K of le pmheaSse1o9r8l7a ) g . are Aegqruiaclu ly lt uvraarliuam ble a . n perceptions of these conditions tdhreo ug o h cc ts u . rrM en e c te eoroof lo g m ic e a te lod ro ro lo uggihctasl re asnudltfargorm ic u p lt ruerca i l m on etperoercoilpoigtiacta io lddrroouugghhttto li n a ks various characteristics of pitation deficiencies; agricultural droughts are largely and potential nesvhaopro ta tr gaenss , gdriifcfuelrteun ra cles im bpea tw cts, focusing the result of soil moisture deficiencies. More time deficits, and piration (ET), seoeinlawca tu te arlien la o ps th es erbceo fo mrpeopnreenctispio ta fttihoenhdyedfr ic oileongciiceasla sy re s te d m et e (e c . tge . d , cdheapreancd te ern is tto ic nsop re fvoa rt i h li . ngAw plant’s demand for water is reservoirs, groundwater). As a result, impacts are out growth, and s t he ofphtyhse ic al sp eeactih fi ecrcpolnadnitt , i ons, biological of phase with those in other economic sectors. Also, the soil. and biological p it rsopsetratg ie esooffw riv a e te rs r ) i n is hoyfd te ro nlougsiecdalfo st rom ra ugletispy le st eam nd s ( ceo .g m ., preets in er gvopiu rs r , dorfocu ro gphst sh Aonu ld opaecrcaotu ional definition of agricultural poses (e.g., power generation, flood control, irri example, adted fi icfifeen re tnstub st natge fo srotfhe cr voap riable susceptibility gation, recreation), further complicating the sequence stage wil soil moisture idneavneleoaprm ly egnrt. o w Fo th r a in n d th q es ueansttiofriacgae ti osnyso te f m im sepsaccatlsa . te Csodm ur pientg it idornoufg or htw , aatnedrrseoq il u ir m em oi lsthuarveeliist tle su impact on final crop yield if top-conflicts between water users increase significantly. moisture en ctosn . ti Hnouw es e , v ffi ear ci , einft th teodm ef e ic eiten early growth The frequency and severity of hydrological drought result. substantial yie c ld y o lo fsss ub m so aiyli ( s19o6f6 te ) n de dfeifniendedaadtrotuhgehtr iv yeerarbaassionnescian le . whW ic hhiptphlee the The impacts of drought are crop specific because a ru gngo re ff g . atLeow ru -n fl oofwfifsre less than the long-term average betw m ee onstcrw op ea s. thPelra -s netn in s g it idvaetepshaenndolm og aitcuarla ti s o ta ngepserv io a d ry stfiomremapney ri osd tr efaam lls s . bIefqu th eenca ie cstuhaalvfelobweefnordea te srem le icnteeddahlisgohv te a m ry p between crops and locations. A period of hydrological drought lioswc on a si cdeerrtead in tothbreesihnop ld ro , gr th es esn . d se rnysic ti ovnedi era g ti roonts ur wt hmeasy tr ecsositnhca id teocw cu it rhsiancarsis ti occailatw io enatw stage for one he it r h -b Hio li w ty e v th ear, ttm he usntubmebeexrco ee fddeadystoanddeftihneelaevheyldorfop lo rgoibcaa l c ca ri n ti coafltesn ta rgeedu fo crea th neotrh is ekro cr fodpr . o A cr gorp ic while missing a drought period is somewhat arbitrary. These criteria ught ium lt pua ra cltpolnancn ro in pgs will Tvhaeryibm et p w ac etesnso tr f e am hy sda ro nldog ri ivcearl ba dsr in osu . ght in an." In Droughts, 41. Routledge, 2016. http://dx.doi.org/10.4324/9781315830896-29.

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"We present here applications of the nanoscale metal particles for transformation of carbon tetrachloride (CT). CT is one of the most prevalent contaminants in soils and aquifers. It has been listed as priority pollutants by the U.S. Environmental Protection Agency, and also appeared on the Superfund National Priority List. There is an urgent need to develop effective control and treatment methods. The purpose of this study was aimed to measure the rate and extent of dechlorination, characterize and quantify reaction intermediates and final products. EXPERIMENTAL METHODS Synthesis of nanoscale iron particles. Nanoscale iron particles were synthesized by adding 1:1 volume ratio of FeCI3*6H20 (0.045M) into NaBH4 (0.25M) solution and mixed vigorously under room temperature (22±1 °С) for a few minutes. Ferric iron (Fe3+) was reduced to zero-valent iron (Fe°) by borohydride, a strong reductant. Metal particles from this reaction have sized mostly in the range between 1 to 100 nanometers [1,2]. BET analysis gave a specific surface area of 35 m2/g. Batch experiments. Batch experiments were conducted with 50 mL serum bottles. In each batch bottle, 20 mL deionized water was mixed with 0.25 g of the nanoscale metal particles. Then, 10 pL stock solution of CT dissolved in methanol was spiked into the solution. Initial organic concentration was about 0.1 mM. The serum bottles were capped with Teflon Mininert valves and mixed on a rotary shaker (30 rpm) at room temperature (22±1°C). Parallel experiments were also performed without the metal particles (control) and with a commercial grade iron (Aldrich, 99%, <10 pm, BET surface area 0.9m2/g ). Methods of Analyses. Organic concentrations were measured by the static headspace gas chromatograph (GC) method. At selected time intervals, 20 pL headspace aliquot was withdrawn from the batch bottle for GC analyses. Concentrations of chlorinated methanes were measured using a HP5890 GC equipped with a DB-624 capillary column (30mx0.32mm) and an electron capture detector (ECD). The detection limit of this method was less than 5 pg/L. Hydrocarbon products in the headspace were qualitatively identified with a Shimadzu QP5000 GC-MS and further quantified with GC analysis by comparing retention times and peak areas with standard gas samples (ethane, ethylene, acetylene, methane and carbon dioxide)." In Hazardous and Industrial Waste Proceedings, 30th Mid-Atlantic Conference, 70. CRC Press, 2014. http://dx.doi.org/10.1201/9781498709453-25.

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Тези доповідей конференцій з теми "L-pgd"

Cortelazzo, S., D. Castagna, M. Galli, T. Barbui, and G. de Gaetano. "INCREASED RESPONSE TO ARACHIDONIC ACID AND U-46619 AND RESISTANCE TO INHIBITORY PR0STAGLANDING IN PATIENTS WITH CHRONIC MYELOPROLIFE RATIVE DISORDERS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643381.

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The potency of prostaglandins (PGs) D2, I2 and as inhibitors of platelet aggregation induced by threshold aggregating concentration (TAC) of arachidonic acid (AA) and U-46619 was determined in platelet rich plasma from 20 normal subjects and 20 patients with thrombocytosis (≥500×l09 platelets/L) secondary to myeloproliferative disorders. Patients had a significantly increased response to both AA and U-46619 (p< 0.02) than the control group (i.e. TAC for AA, mean+SD, was 0.41±0.10 mM vs 0.48±0.12 mM ; TAC for U-46619 was 220±155 nM vs 375±102 nM). In contrast, platelet sensitivity to all three inhibitoty PGs was significantly lower in patients than in normal subjects. Indeed the threshold inhibiting concentrations (nM) of PGs against AA were the following: PGD2 20.33±4.16 vs 7.00±2.62 (p< 0.001), PGI2 0.76±0.46 vs 0.34±0.22 (p< 0.01) and PGE1 11.83±3.97 vs 6.50±2.22 (p<0.001). The corresponding inhibitory concentrations (nM) against U-46619 were the following: PGD2 4.67±4.24 vs 0.76±0.30 (p< 0.02), PGI2 1.15±0.96 vs 0.03±0.01 (p< 0.0001) and PGE1 21.12±15.27 vs 0.68± 0.30 (p< 0.0001). Selective pharmacologic inhibition of TxA2 sinthase by 40 μM dazoxiben resulted in 6 out of 11 “responders” in patients and 7 out of 10 in normal subjects, a difference not statistically significant. Serum TxB2 was slightly, but not significantly lower in patients than in controls (360±143 ng vs 390±155 ng/3×109 platelets/mL). It is suggested that in patients with myeloproliferative disorders platelet arachidonate metabolism is normal, but the functional response to aggregating and antiag-gregating prostanoids is altered towards a potential hyperaggrega bility. The relevanbe of this “in vitro” finding to thrombotic or haemorragic complications in these patients remains to be establi shed.

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Terres, W., C. Hamm, W. Kupper, and W. Bleifeld. "PLATELET AGGREGABLLITY AND METABOLISM IN PATIENTS WITH UNSTABLE ANGINA PECTORIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643777.

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Several platelet products indicating platelet activation have been detected in blood and urine of patients (PTS) with angina pectoris (AP) at rest. Platelet activation mainly depends on local changes in the morphology or biochemical behaviour of the vessels. Whether platelet hyperaggregability is of additional importance in the pathogenesis of unstable AP is up to now unclear. In a prospective trial we therefore evaluated 32 patients (PTS) with coronary heart disease, 16 with AP at rest during the last 8 hours before blood collection and 16 age and sex matched controls with stable exertional AP. Platelet aggregation was measured upon stimulation with ADP (0.5, 1 and 10 μmol/l) and collagen (1and 5μg/ml), and c-AMP was determined in platelet rich plasma before, and, as an estimate of platelet adenylate cyclase activity, after stimulation of this enzyme with PGE 1 (10 μmol/l for 30 s). For all concentrations of both ADP and collagen no significant differences in the rates and extents of aggregation could be found between the groups. Correspondingly, the mean (±. 2 SEM) concentrations of c-AMP were similar, basally (4.1 ±.1.4 pmol/ml for PTS withunstable AP and 5.3 t 1.3 pmol/ml for PTS with stable AP)and after stimulation of platelet adenylate cyclase with PGE 1 (14.8 ± 4.1 vs. 17.2 ± 2.8 pmol/ml).Conclusion: No generalized platelet hyperaggregability could be detected in our PTS with unstable AP when compared to controls with stable exertional AP.

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Chin, Kazuo, Yuichi Chihara, Kousuke Aritake, Yuka Harada, Masanori Azuma, Yoshiro Toyama, Kimihiko Murase, et al. "A Possible Specific Urine Biomarker For Severe Obstructive Sleep Apnea And Cardiovascular Diseases-Lipocalin-Type Prostaglandin D Synthase (L-PGDS)." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2179.

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Shumatova, N. V. "LABOUR CONDITIONS AND POSSIBILITY OF APPLICATION OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE IN WORKERS EXPOSED TO FIBROGENIC SILICATE DUST." In The 16th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2021). FSBSI “IRIOH”, 2021. http://dx.doi.org/10.31089/978-5-6042929-2-1-2021-1-598-600.

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Abstract. Labour conditions of workers contacting with fibrogenic silicate dust in isolators’ production were studied. Additional examination included determination of the degree of endothelial disfunction, apoptosis and systemic inflammation. Besides the effect of Ethylmethylhydroxypyridine succinate on these parameters and the lipid profile was evaluated. Atherogenic changes of the lipid profile, moderate endothelial disfunction (level of circulating endotheliocytes is 6,04±1,97*104/l), slight tension of apoptosis (TNF-α 8,11±6,67 pg/ml) and activation of systemic inflammation (C-RP 8,1±4,5 mg/l) were found. Application of Ethylmethylhydroxypyridine succinate led to the partial correction of dyslipidemia and endothelial disfunction without the significant effect on other researching laboratory parameters; significant improvement of respiratory function was noted.

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Sugimori, Daisuke, Kiyoto Kajiyama, Shunsuke Kawashima, and Yuho Matsumoto. "Phosphatidylglycerol-specific Phospholipase C from Amycolatopsis Sp. NT115: Biochemical Characterization and Heterologous Expression." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/fmmj5845.

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In recent years, phosphatidylglycerol (PG) has been attracting attention in the field of cell physiology such as photosynthesis and germ cells, or clinical diagnosis. Most of phospholipids containing PG are analyzed using HPLC and LC-MS; however, it has been desired to develop an enzymatic assay method for determination of PG concentration in a simple, easy, and high-through put.In our presentation, biochemical characterization of a PG-specific phospholipase C (PG-PLC) from Amycolatopsis sp. NT115 will be reported. PG-PLC (molecular mass, 55 kDa) showed maximal activity at pH 6.0 and 55°C. PG-PLC showed almost no activity on other diacylphospholipids, dipalmitoylPG, lysoPG and glycerol 3-phosphate, demonstrating PG-PLC can recognize not only the substrate headgroup but also the acyl chains. PG-PLC was inhibited by Zn2+; however, it was hardly inhibited by EDTA and non-ionic surfactants such as Triton X-100, Tween 80, Briji 35 and Nonidet P-40. PG-PLC activity was enhanced by 1 mM Mn2+, Al3+, 0.1% sodium deoxycholate by 1.3-2.5 folds. Recombinant PG-PLC (rPG-PLC) was extracellularly produced using Streptomyces lividans/pUC702 expression system. However, unexpectedly it was produced with the N-terminal region deleted by ca. 230 amino acids. As a result, the stability of the deletion mutant (Δ230aa) was markedly decreased. In 96 h culture, rPG-PLC with His6-tag was produced with 0.188 U/mL and 3.36×10-2 U/mg-protein in the culture supernatant. Moreover, 1.52 mg-protein of the purified Δ220aa (2.5 U/mL, 16.4 U/mg-protein) was yielded from 0.9 L of the culture supernatant by His-tag affinity chromatography. Using the purified Δ220aa, kinetic parameters were determined to be Km=0.368 mM, 99.2 µM/min (6.51 mmol/min/mg-protein), kcat=5.29×10-2 s-1, kcat/Km=0.256 mM-1s-1 for POPG.

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Ponomarjova, Olga, Ilga Sematovica, Inga Piginka-Vjaceslavova, and Aida Vanaga. "Cattle (Bos Taurus) endometrium morphology on the seventh day of the estrous cycle." In Research for Rural Development 2020. Latvia University of Life Sciences and Technologies, 2020. http://dx.doi.org/10.22616/rrd.26.2020.021.

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The aim of our study was to describe the histopathological and cytological characteristic of the cow endometrium on the seventh day of the estrous cycle. In this study, 11 different breeds’ dairy cows (78.18 ± 37.46 months old, in 3.6 ± 2.17 lactation, the mean body condition score 3.4 ± 0.72 (5 points scale)) from Research and Study farm ‘Vecauce’ were selected. All cows were more than 210 days postpartum. Overall health and reproductive tract examination was performed, progesterone (P4) and estradiol (E2) concentration in blood serum were established and the biopsy and cytology samples of endometrium were taken. Mean E2 concentration was 14.92 ± 7.92 pg mL-1, mean P4 concentration was 13.64 ± 9.44 nmol L-1. The mean percentage in the cytology slides was established: epithelial cells 89 ± 9%, polimorphonuclear leukocytes (PMN) 6 ± 5%. Cytological subclinical endometritis (SE) was confirmed in 5 cows. Histopathological findings (out of 22 samples): endometrium stromal edema in 14, hemosiderin and hemosiderophages in 8, supranuclear vacuolization in 12, pseudodecidual reaction in 12 samples. No subnuclear vacuolization and mitosis in the glandular epithelium were detected. Histopathological examination did not reveal SE. Morphology between the uterine horns with and without corpus luteum (CL) and between cows with serum P4 level higher than 15 nmol L-1 and lower than 15 nmol L-1 were not statistically different (p>0.05). In conclusion, histopatological examination is more reliable diagnostic method for SE. Future investigation should be performed to establish cut-off values for the diagnosis of SE in cows more than 210 days postpartum.

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Petraiuolo, W., E. Bovill, and J. Hoak. "THE LUPUS ANTICOAGULANT DOES NOT INHIBIT THE RELEASE OF PROSTACYCLIN FROM HUMAN ENDOTHELIAL CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644228.

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Decreased endothelial cell production of prostacyclin (PGI2) in response to the lupus anticoagulant has been previously demonstrated, and postulated to have a causal relationship to the thrombotic events associated with the lupus anticoagulant. Five patients who exhibited the anticoagulant were studied in an effort to determine if a relationship exists between exposure of endothelial cells to the lupus anticoagulant and decreased production of prostacyclin (PGI2). Human endothelial cells derived from human umbilical vein grown in culture were exposed to IgG fractions of patient plasmas containing the lupus anticoagulant. The amount of PGI2 released was determined by radioimmunoassay for 6-keto-PGF-l-alpha. The average PGI2 release in the controls was 20.6 picomol/500,000 endothelial cells, whereas those cells exposed to the lupus anticoagulant had a range of 25 to 114 picmol/500,000 cells. We were unable to demonstrate inhibition of the release of PGI2 by human endothelial cells, following exposure to the lupus anticoagulant.(Supported by NIH Grant HL 33723-2 and a Specialized Center of Research in Thrombosis Award HL 35058-01 from the National Heart, Lung and Blood Institute.)

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Baskova, I., and G. Nikonov. "LEECH PROSTAGLANDINS AND THE ENZYME DESTAB ILASE AS THROMBOLYTIC AGENTS OF THE PREPARATIONS FROM THE MEDICINAL LEECHES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643037.

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The thrombolytic effect of the leeching of thromboflebits has been well known from the ancient time. It is provided by the propertiesof the salivary gland secretion though leech saliva does not show proteolytic activity and does not activate plasminogen to plasmin. Butin leech saliva we have found the enzyme destabilase (isopeptidase-glutaminase) which hydrolyze the crosslinked fibrin. This mechanism can be the basis of a new type of fibrinolysis. We have observed the high affinity of destabilase to fibrin that provides the dissolutionof thrombous in circulating citrate blood in experiments in vitro. The high affinity of destabilase to fibrin correlates with its high ability to bound L-lysine, which inhibits isopeptidase and glutaminase activity of destabilase. Using radioimmunoassay for 6-keto-PgF1 we have found prostaglandins in saliva and other preparations from the medicinal leeches:3400 pg/ml of leech saliva322 pg/mg of protein (the whole leeches extract)351 pg/mg of protein (the head region extract)63 pg/mg of protein (blood from the intestinal tract)But the leech prostaglandins in contrast to 6-keto-PgF1 has Strongly inhibited platelets aggregation stimulated by thrombin. The leech prostaglandins stimulate thrombolysis in rats after intravenous injection or oral administration. We have supposed that thrombolytic effect of leech prostaglandins is induced by the release of tissue plasminogen activator from vessel wall.In the experiments on rats it has been shown that thrombolytic effect of leech saliva and preparations from the medicinal leeches is provided by the summary effect of the leech prostaglandins and the enzyme destabilase. After the extraction of prostaglandins by ethylacetate thrombolytic effect is diminished by 4O per cent.

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Adriaty, A. Dinar, M. Irfan Hadi, Irmadita Citrashanty, Iswahyudi, Indropo Agusni, Shinzo Izumi, and Cita S. P. "Serological Antibody Profile IgM and IgG of Mycobacterium leprae PGL-1 and L-ESAT-6 in Patients and Household Contact from Leprosy Endemic Area in East Java Indonesia." In The 23rd Regional Conference of Dermatology 2018. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0008156703230327.

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Echevarria, Victor. "Engineering Solutions to the Problem of Hypersalinity in Florida Power & Light’s Turkey Point Cooling Canals." In SNAME Maritime Convention. SNAME, 2010. http://dx.doi.org/10.5957/smc-2010-stu01.

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The aim of this project is to investigate engineering methods to reduce salinity in the cooling canals at the Florida Power & Light (FP&L) Turkey Point Power Plant. In order to stop discharging hot water from the plant into the adjacent Biscayne Bay, a cooling canal system was made operational in 1972 that occupies an area 3.2 km wide by 8.0 km long extending south of the plant. The 5,900 acre canal system has been measured at twice the salinity of the adjacent Biscayne Bay at as high as 68 ppt [Appendix i]. Florida Power & Light added a canal along the western perimeter of the cooling canal system to intercept seepage. The interceptor ditch enables FP&L to pump seepage back into the canal system during the dry season thus reducing the groundwater flow of hypersaline water to the west. The Florida Department of Environmental Protection (FDEP) and the South Florida Water Management District (SFWMD) are monitoring a saltwater plume migrating west of FP&L property (FDEP/SFWMD Miami-Dade Saltwater Intrusion Presentation pg 3). Tidal influences have a profound effect on saltwater intrusion, so it is difficult to quantify the influence of the canals on this plume. To ensure that FP&L has no culpability in the contamination of ground water, the cooling canals should either operate at a lower level of salinity or be isolated to restrict flow to underground sources of water. Isolation, however, is not an appealing option as the methods which have been conceptualized are highly invasive. Environmental concerns are abundant as the ecosystem within the cooling canals supports at least 17 protected species of birds and animals of South Florida. Over 25% of the world’s population of the American crocodile resides in the Turkey Point cooling canals. Very few organisms require a hypersaline condition to thrive; therefore, lowering the salt concentration of the canal system is not expected to have adverse effects upon the ecosystem. Careful attention must be paid to ensure wildlife survival during treatment and/or disposal system development and operation.

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Звіти організацій з теми "L-pgd"

Bennett, Alan B., Arthur Schaffer, and David Granot. Genetic and Biochemical Characterization of Fructose Accumulation: A Strategy to Improve Fruit Quality. United States Department of Agriculture, June 2000. http://dx.doi.org/10.32747/2000.7571353.bard.

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The goal of the research project was to evaluate the potential to genetically modify or engineer carbohydrate metabolism in tomato fruit to enhance levels of fructose, a sugar with nearly twice the sweetness value of other sugars. The specific research objectives to achieve that goal were to: 1. Establish the inheritance of a fructose-accumulating trait identified in F1 hybrids of an inferspecific cross between L. hirsutum XL. esculentum and identify linked molecular markers to facilitate its introgression into tomato cultivars. This objective was completed with the genetic data indicating a single major gene, termed Fgr (Fructose glucose ratio), that controlled the partitioning of hexose in the mature fruit. Molecular markers for the gene, were developed to aid introgression of this gene into cultivated tomato. In addition, a second major gene encoding fructokinase 2 (FK2) was found to be a determinant of the fructose to glucose ratio in fruit. The relationship between FK2 and Fgr is epistatic with a combined synergistic effect of the two hirsutum-derived genes on fructose/glucose ratios. 2. Characterize the metabolic and transport properties responsible for high fructose/glucose ratios in fructose-accumulating genotypes. The effect of both the Fgr and FK2 genes on the developmental accumulation of hexoses was studied in a wide range of genetic backgrounds. In all backgrounds the trait is a developmental one and that the increase in fructose to glucose ratio occurs at the breaker stage of fruit development. The following enzymes were assayed, none of which showed differences between genotypes, at either the breaker or ripe stage: invertase, sucrose synthase, FK1, FK2, hexokinase, PGI and PGM. The lack of effect of the FK2 gene on fructokinase activity is surprising and at present we have no explanation for the phenomenon. However, the hirsutum derived Fgr allele was associated with significantly lower levels of phosphorylated glucose, G1c-1-P and G1c-6-P and concomitantly higher levels of the phosphorylated fructose, Fru-6-P, in both the breaker and ripe stage. This suggests a significant role for the isomerase reaction. 3. Develop and implement molecular genetic strategies for the production of transgenic plants with altered levels of enzymes that potentially control fructose/glucose ratios in fruit. This objective focused on manipulating hexokinase and fructokinase expression in transgenic plants. Two highly divergent cDNA clones (Frk1 and Frk2), encoding fructokinase (EC 2.7.1.4), were isolated from tomato (Lycopersicon esculentum) and a potato fructokinase cDNA clone was obtained from Dr. Howard Davies. Following expression in yeast, each fructokinase was identified to code for one of the tomato or potato fructokinase isoforms Transgenic tomato plants were generated with the fructokinase cDNA clone in both sense and antisense orientations and the effect of the gene on tomato plants is currently being studied.

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