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Статті в журналах з теми "KU70 gene"
Ouyang, Honghai, Andre Nussenzweig, Akihiro Kurimasa, Vera da Costa Soares, Xiaoling Li, Carlos Cordon-Cardo, Wen-hui Li, et al. "Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo." Journal of Experimental Medicine 186, no. 6 (September 15, 1997): 921–29. http://dx.doi.org/10.1084/jem.186.6.921.
Повний текст джерелаLi, Han, Hannes Vogel, Valerie B. Holcomb, Yansong Gu, and Paul Hasty. "Deletion of Ku70, Ku80, or Both Causes Early Aging without Substantially Increased Cancer." Molecular and Cellular Biology 27, no. 23 (September 17, 2007): 8205–14. http://dx.doi.org/10.1128/mcb.00785-07.
Повний текст джерелаSucharov, Carmen C., Steve M. Helmke, Stephen J. Langer, M. Benjamin Perryman, Michael Bristow та Leslie Leinwand. "The Ku Protein Complex Interacts with YY1, Is Up-Regulated in Human Heart Failure, and Represses α Myosin Heavy-Chain Gene Expression". Molecular and Cellular Biology 24, № 19 (1 жовтня 2004): 8705–15. http://dx.doi.org/10.1128/mcb.24.19.8705-8715.2004.
Повний текст джерелаWeterings, Eric, Nicole S. Verkaik, Guido Keijzers, Bogdan I. Florea, Shih-Ya Wang, Laura G. Ortega, Naoya Uematsu, David J. Chen, and Dik C. van Gent. "The Ku80 Carboxy Terminus Stimulates Joining and Artemis-Mediated Processing of DNA Ends." Molecular and Cellular Biology 29, no. 5 (December 22, 2008): 1134–42. http://dx.doi.org/10.1128/mcb.00971-08.
Повний текст джерелаGhonim, Mohamed Ahmed, Kusma Pyakurel, Hanh Luu, Samuel Okpechi, Jihang Ju, and Hamid Boulares. "The catalytic subunit of DNA-PK has a unique function in inflammation independently of Ku70 and DNA repair: a new opportunity to target the enzyme without interfering with DNA repair." Journal of Immunology 200, no. 1_Supplement (May 1, 2018): 173.18. http://dx.doi.org/10.4049/jimmunol.200.supp.173.18.
Повний текст джерелаFu, Chengcheng, Peishuai Chen, Wu Depei, and Zixing Chen. "Study of Expression of Ku70 and NHEJ in CML Cells." Blood 112, no. 11 (November 16, 2008): 3223. http://dx.doi.org/10.1182/blood.v112.11.3223.3223.
Повний текст джерелаGao, Chao, Guangxu Jin, Elizabeth Forbes, Lingegowda S. Mangala, Yingmei Wang, Cristian Rodriguez-Aguayo, Paola Amero, et al. "Inactivating Mutations of the IK Gene Weaken Ku80/Ku70-Mediated DNA Repair and Sensitize Endometrial Cancer to Chemotherapy." Cancers 13, no. 10 (May 20, 2021): 2487. http://dx.doi.org/10.3390/cancers13102487.
Повний текст джерелаImamichi, Tomozumi, Xing Zhang, Ming Zhou, Richard Lempicki, Michael Baseler, Timothy Veenstra, Howard Young, and H. Clifford Lane. "Ku70 is a novel cytosolic DNA sensor that induces a Type-III rather than Type-I IFN via activation of IRF-1 and IRF-7. (116.11)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 116.11. http://dx.doi.org/10.4049/jimmunol.186.supp.116.11.
Повний текст джерелаKoh, Chong Mei, Yanbin Liu, Moehninsi, Minge Du, and Lianghui Ji. "Molecular characterization of KU70 and KU80 homologues and exploitation of a KU70-deficient mutant for improving gene deletion frequency in Rhodosporidium toruloides." BMC Microbiology 14, no. 1 (2014): 50. http://dx.doi.org/10.1186/1471-2180-14-50.
Повний текст джерелаQing, Yulan, Zhengqi Wang, Shigemi Matsuyama, Kevin D. Bunting, and Stanton L. Gerson. "Rescue of the HSC Maintenance Defects in Ku70-Deficient Mice by Overexpression of Bcl2 Reveals a Novel Role of Bcl2 in HSC." Blood 120, no. 21 (November 16, 2012): 1235. http://dx.doi.org/10.1182/blood.v120.21.1235.1235.
Повний текст джерелаДисертації з теми "KU70 gene"
Wickersham, Stephanie. "The down-regulation of Ku70, DNA-PKcs, and Parp-1 in mammalian cell lines." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2012, 2012. http://hdl.handle.net/10133/3401.
Повний текст джерелаxv, 168 leaves : ill. ; 29 cm
Ghezzi, Tiago Leal. "Comparação da expressão gênica do KRAS mutante, KU70, TACSTD2 e SERIN1 em tecidos tumoral e normal de pacientes com câncer colorretal pela técnica de PCR em tempo real." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/22996.
Повний текст джерелаINTRODUCTION: Knowledge of the molecular pathways and of the specific alterations responsible for the unfavorable progression of patients with CCR appears essential for the development of more effective therapies. PURPOSE: To compare the quantitative expression of the genes TACSTD2, mutant KRAS, Ku70 and SERIN1 in samples of normal and tumoral tissues of patients with CCR and to relate their expression to clinicopathologic characteristics. METHODS: 37 patients with CCR were studied. The patients had been operated on between July 2005 and July 2009, and their frozen samples of tumoral and normal tissues had been stored in a tissue bank. The expression of the genes TACSTD2, mutant KRAS, Ku70 and SERIN1 was quantified through the technique of real time polymerase chain reaction. RESULTS: The mutant KRAS expression was higher in the tumoral tissue than in the normal tissue (p = 0,024). Although not significant, the tumoral expression of the genes Ku70, TACSTD2 and SERIN1 was respectively lower, equal to, and higher than in the normal tissue. Statistically significant association was also observed between age and mutant KRAS expression in normal tissue and between poorly-differentiated tumors and Ku70 expression in normal tissue. No other statistically significant associations were observed. CONCLUSIONS: Tumoral tissues express mutant KRAS at higher levels than normal tissues in the casuistic of 37 patients with CCR studied through the technique of PCR real time.
Mo, Wanbin [Verfasser]. "The Expression and Significance of MGMT, Ku80 and Ki67 Gene in Different Grades of Spinal gliomas / Wanbin Mo." Kiel : Universitätsbibliothek Kiel, 2015. http://d-nb.info/1069814636/34.
Повний текст джерелаGhosh, Dipayan. "Understanding Nonhomologous DNA End Joining: Novel Insights Into Mechanism and Regulation." Thesis, 2022. https://etd.iisc.ac.in/handle/2005/5847.
Повний текст джерелаHua, Chialing, and 花嘉玲. "The role of Ku80 in DNA repair and gene regulation." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/12027820768391790114.
Повний текст джерела國立清華大學
輻射生物研究所
84
DNA雙股斷裂是當細胞遭到游離輻射照射時產生最嚴重的傷害.為了瞭解細 胞輻射敏感的機制,有一些游離輻射敏感的突變株,已從中國倉鼠卵巢野生 型K1細胞被篩選出來 .其中xrs5和xrs6已知缺失將DNA雙股斷裂重新連結 的能力,同時也對MMS, EMS,UV等DNA傷害劑敏感;除此之外在這些突變株中 有十一種基因的表現較差.從最近的研究推論xrs突變株缺乏 Ku蛋白質 的80kDa次單元及Ku蛋白質所具有與DNA端點結合的特性,在xrs突變株中表 現人類Ku80則可使此轉染細胞株之DEB活性與對游離輻射的抗性同時回復. 為了解DNA雙股斷裂的修復系統,本實驗室已由xrs6細胞株中篩選得到表型 自然回復株SR16,由先前的研究發現SR16對X-ray和UV具有抗性,然而卻對 MMS和EMS依然敏感;同時SR16細胞也具有DEB活性.本論文主要在探討 Ku蛋 白質是否參與MMS,EMS和UV所造成DNA傷害的修復路徑.人類Ku80互補DNA是 利用反轉錄及聚合酵素連鎖反應的方法獲得,此 cDNA接著被選殖於可在真 核生物系統表現選殖DNA的表現載體pcDNA3中,之後利用lipofection的方 法將此表現質體送入xrs6細胞中.利用G418篩選穩定的轉染細胞,並將之培 養成細胞株;將十二個獨立細胞株混合而成的混合細胞株對IR具較高之抗 性.以獨立細胞株中的x6hk803與混合細胞株進行之後的實驗顯示:雖然利 用北方墨點轉漬實驗在轉染細胞株中,無法檢測到 Ku80 mRNA的訊號,但可 藉由反轉錄及聚合酵素連鎖反應,偵測到轉染細胞株中有人類Ku80 mRNA表 現的情形.雖然利用西方墨點轉漬實驗在轉染細胞株中,無法檢測到Ku80蛋 白質的訊號,但可利用電泳泳動偏移測定偵測到 Ku80轉染細胞株中具Ku蛋 白質特有的DEB活性,故確知在x6hk803及mix transfectant中有Ku之表現 而且具生物活性.由細胞存活實驗中得知Ku80轉染細胞株對MMS和EMS具抗 性,但對UV敏感.本實驗也對Ku是否調控某些基因的表現加以探討.結果顯 示在xrs突變株中mRNA表現量較低的基因-B52與B29在Ku80轉染細胞中表現 仍然不佳;故 Ku蛋白質並不參與調控這些基因的表現.從本論文結果推論 Ku蛋白質參與X-ray,MMS,和EMS所造成DNA傷害的修復路徑;同時,參與另一 機制的分子具有與DNA free ends結合的能力,因為 SR16細胞對IR及UV具 抗性並具有DEB活性,但對 MMS和EMS依然敏感.
Ting, Hui-Min, and 丁慧敏. "A DNA Microarray Study of Global Gene Expression And Radiation biological Effects of Ku80 Gene Knockout Cells." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/42895551689872609697.
Повний текст джерела國立陽明大學
放射醫學科學研究所
90
DNA contains genetic information which is essential to the cell’s physiological mechanisms. In the event of DNA damage, repair mechanisms are activated in order to initiate pathways which will lead to repair of the damage, so as to avoid cell death, mutation and thus to preserve the integrity of the genome. Since DNA repair plays a vital role in the cell’s survival and consequently to the survival of the whole organism, we have chosen to study the Ku protein, which plays an important role in DNA double strand break repair particularly the non-homologous end rejoining repair mechanism. In this study, we used Ku80 knockout mouse embryo fibroblasts and its wild-type counterpart to study the differences in global gene expression between the two cell lines under irradiated or non-irradiated conditions. Survival dose response using colony formation showed high radiosensitivity of the knockout cells relative to the wild-type. Flow cytometry results showed that both cell types after exposure to 10Gy and harvested at 12 hr post-irradiation exhibited G2 arrest. G1 arrest was also observed in the wild-type but not in the knockout cells. For each cell line, microarray data revealed a small number of differentially expressed genes between irradiated and their control counterparts. However, more genes were differentially expressed between non-irradiated Ku80 knockout and wild-type cells and between irradiated ones. In our study, gene expression data appear to indicate that genes involved in nucleotide excision repair, homologous recombination repair and non-homologous end rejoining repair are preferably stimulated. In both cell lines, cyclin G, which is regulated by p53 protein post damage, has high gene expression level. These preliminary gene expression data suggest that further time-dependent study may reveal molecular pathways.
Частини книг з теми "KU70 gene"
Yin, Liu-hua, Lan Zhang, Ling Liu, Hongfei Zhang, Li Hou, and De-pei Wang. "Exploitation of a KU70-Deficient Mutant for Improving Gene Deletion Frequency in Aspergillus niger." In Lecture Notes in Electrical Engineering, 105–15. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4801-2_11.
Повний текст джерелаMak, Tak W., Josef Penninger, John Roder, Janet Rossant, and Mary Saunders. "Ku80." In The Gene Knockout FactsBook, 653–54. Elsevier, 1998. http://dx.doi.org/10.1016/b978-012466044-1/50365-3.
Повний текст джерелаТези доповідей конференцій з теми "KU70 gene"
De Figueiredo, Wenberger Lanza Daniel, Paula Taquita Serra, and Diego Monteiro De Carvalho. "UTILIZAÇÃO DO SISTEMA CRISPR-CAS9 PARA O TRATAMENTO DE CARCINOMA PAPILÍFERO DE TIREOIDE: REVISÃO DE LITERATURA." In I Congresso Brasileiro de Biotecnologia On-line. Revista Multidisciplinar de Educação e Meio Ambiente, 2021. http://dx.doi.org/10.51189/rema/1105.
Повний текст джерелаЗвіти організацій з теми "KU70 gene"
Weil, Clifford F., Anne B. Britt, and Avraham Levy. Nonhomologous DNA End-Joining in Plants: Genes and Mechanisms. United States Department of Agriculture, July 2001. http://dx.doi.org/10.32747/2001.7585194.bard.
Повний текст джерелаTzfira, Tzvi, Michael Elbaum, and Sharon Wolf. DNA transfer by Agrobacterium: a cooperative interaction of ssDNA, virulence proteins, and plant host factors. United States Department of Agriculture, December 2005. http://dx.doi.org/10.32747/2005.7695881.bard.
Повний текст джерела