Добірка наукової літератури з теми "Knockin mouse model"
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Статті в журналах з теми "Knockin mouse model"
Savva, Isavella, Charalampos Stefanou, Myrtani Pieri, Dorin B. Borza, Kostas Stylianou, George Lapathitis, Christos Karaiskos, Gregoris Papagregoriou, and Constantinos Deltas. "MP036A NOVEL KNOCKIN MOUSE MODEL FOR ALPORT SYNDROME." Nephrology Dialysis Transplantation 31, suppl_1 (May 2016): i354. http://dx.doi.org/10.1093/ndt/gfw182.06.
Повний текст джерелаLuo, Yichen, Liang Du, Zhimeng Yao, Fan Liu, Kai Li, Feifei Li, Jianlin Zhu, et al. "Generation and Application of Inducible Chimeric RNA ASTN2-PAPPAas Knockin Mouse Model." Cells 11, no. 2 (January 14, 2022): 277. http://dx.doi.org/10.3390/cells11020277.
Повний текст джерелаde Winter, J., M. Yuen, R. Van der Pijl, F. Li, S. Shengyi, S. Conijn, M. Van de Locht, et al. "P.162Novel Kbtbd13R408C-knockin mouse model phenocopies NEM6 myopathy." Neuromuscular Disorders 29 (October 2019): S95. http://dx.doi.org/10.1016/j.nmd.2019.06.217.
Повний текст джерелаWegener, Eike, Cornelia Brendel, Andre Fischer, Swen Hülsmann, Jutta Gärtner, and Peter Huppke. "Characterization of the MeCP2R168X Knockin Mouse Model for Rett Syndrome." PLoS ONE 9, no. 12 (December 26, 2014): e115444. http://dx.doi.org/10.1371/journal.pone.0115444.
Повний текст джерелаRose, Samuel J., Lisa H. Kriener, Ann K. Heinzer, Xueliang Fan, Robert S. Raike, Arn M. J. M. van den Maagdenberg, and Ellen J. Hess. "The first knockin mouse model of episodic ataxia type 2." Experimental Neurology 261 (November 2014): 553–62. http://dx.doi.org/10.1016/j.expneurol.2014.08.001.
Повний текст джерелаSundberg, J. P., C. H. Pratt, K. A. Silva, V. E. Kennedy, L. Goodwin, W. Qin, and A. Bowcock. "394 Card14 knockin mouse model of psoriasis and psoriatic arthritis." Journal of Investigative Dermatology 136, no. 5 (May 2016): S70. http://dx.doi.org/10.1016/j.jid.2016.02.428.
Повний текст джерелаBaelde, R., A. Fortes Monteiro, E. Nollet, R. Galli, J. Strom, J. van der Velden, C. Ottenheijm, and J. de Winter. "P400 Kbtbd13R408C-knockin mouse model elucidates mitochondrial pathomechanism in NEM6." Neuromuscular Disorders 33 (October 2023): S123. http://dx.doi.org/10.1016/j.nmd.2023.07.231.
Повний текст джерелаYuan, Weiming, Xiangshu Wen, Ping Rao, Seil Kim, and Peter Cresswell. "Characterization of a human CD1d-knockin mouse (106.44)." Journal of Immunology 188, no. 1_Supplement (May 1, 2012): 106.44. http://dx.doi.org/10.4049/jimmunol.188.supp.106.44.
Повний текст джерелаGuo, Qinxi, Hui Zheng, and Nicholas John Justice. "Central CRF system perturbation in an Alzheimer's disease knockin mouse model." Neurobiology of Aging 33, no. 11 (November 2012): 2678–91. http://dx.doi.org/10.1016/j.neurobiolaging.2012.01.002.
Повний текст джерелаNomura, Naohiro, Masato Tajima, Noriko Sugawara, Tetsuji Morimoto, Yoshiaki Kondo, Mayuko Ohno, Keiko Uchida, et al. "Generation and analyses of R8L barttin knockin mouse." American Journal of Physiology-Renal Physiology 301, no. 2 (August 2011): F297—F307. http://dx.doi.org/10.1152/ajprenal.00604.2010.
Повний текст джерелаДисертації з теми "Knockin mouse model"
Liu, Huifang, and 刘慧芳. "Creation and characterization of a LRRK2 knockin mouse model to elucidate the pathogenesis of Parkinson's disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46090903.
Повний текст джерелаManett, Taylor. "Investigating the pathogenicity of an autism-related CNTNAP2 missense variant in a novel mouse model." Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS721.pdf.
Повний текст джерелаAutism spectrum disorders (ASD) are neurodevelopmental disorders, defined by deficits in social interaction and restricted or repetitive behavior. ASD show high heritability, shaped by rare monogenic mutations, as well as variations in numerous susceptibility genes. Intriguingly, CNTNAP2, encoding the protein Caspr2, is considered to be one of the major ASD-risk genes, with a large number of heterozygous missense variants identified in patients. Cntnap2 knockout mice display ASD-related behavioral deficits supporting human genetic data. However, the clinical significance of the heterozygous variants has not yet been demonstrated and is still debated. The PhD project aimed to unravel this question by evaluating the pathogenicity of an inherited heterozygous missense CNTNAP2 variant identified in a French ASD patient, I236S, which was predicted to be disease-causing and may be representative of a large class of CNTNAP2 variants. We generated a novel knockin mouse model, the KI-I236S mice, and conducted a study comparing wild-type and KI-I236S heterozygous (HET) mice. Caspr2 is a neuronal cell-adhesion transmembrane glycoprotein originally identified in the juxtaparanodal regions of the nodes of Ranvier in mature myelinated neurons. Recently, studying Cntnap2 knockout mice the lab showed that Caspr2 also acts as a major regulator of axon development and myelination. In the brain, Caspr2 controls axon diameter at early postnatal developmental stages, cortical neuron intrinsic excitability at the onset of myelination, and axon diameter and myelin thickness at adulthood. Caspr2 also modulates axon diameter, myelin thickness and node of Ranvier morphology in peripheral nerves. We thus assessed the impact of the variant I235S on axon development, myelination, and node of Ranvier organization in both the central and peripheral nervous system, as well as thoroughly characterizing the behavior of HET KI-I236S mice, using a battery of tests that may indicate cognitive, motor, and sensorimotor deficits. Interestingly, KI-I236S HET mice display sex-dependent cognitive and somatosensory behavioral deficits as compared to wild-type mice (social interaction slightly decreased in females; heat sensitivity and muscular strength slightly decreased in males). They also show sex-dependent alterations in myelinated axons and unmyelinated sensory C-fibers of the peripheral nervous system. Brain analyses do not show major myelination defects in adult mutant mice, but suggest that the variant could perturb the functions of Caspr2 at the onset of myelination, leading likely to an acceleration of the myelination processes at early stages. Thus, our results indicate that CNTNAP2 heterozygous missense variants such as I236S can affect Caspr2 function in a sex-dependent manner in vivo and suggest that the CNTNAP2 variants of the same class could indeed be pathogenic and contribute to the development of ASD patients, and/or contribute to inter-individual variability in physiological conditions
Sarowar, Tasnuva [Verfasser]. "Characterization of RICH2 knock-out mouse model / Tasnuva Sarowar." Ulm : Universität Ulm, 2017. http://d-nb.info/1136370226/34.
Повний текст джерелаNaidu, Shan Krishnan. "PATHOLOGY OF THREE TRANSGENIC MOUSE LINES WITH UNIQUE PTEN MUTANT ALLELES." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1282941122.
Повний текст джерелаALBINI, MARTINA. "Functional interaction between BDNF and Kidins220: a study in primary mouse astrocytes and in an adult conditional knock-out mouse model." Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1077504.
Повний текст джерелаSaka, Asantha. "Investigating the toxic fragment hypothesis of Huntingdon disease pathogenesis using knock-in mouse models." Thesis, University of Glasgow, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443414.
Повний текст джерелаNgai, Ying Fai Tiffany. "The low-density lipoprotein receptor knock-out mouse : a model for the study of energy balance." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/23477.
Повний текст джерелаPietra, Gianluca. "Spontaneous and stimulus-evoked spiking activities in olfactory sensory neurons from Kir2.1 knock-in and TMEM16B knock-out mouse models." Doctoral thesis, SISSA, 2016. http://hdl.handle.net/20.500.11767/4895.
Повний текст джерелаSilva, Lopes Katharina da [Verfasser]. "Novel insights into Titin’s mobility and function derived from a knock-in mouse model / Katharina da Silva Lopes." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1026356598/34.
Повний текст джерелаSierig, Ralph [Verfasser], Christoph [Gutachter] Englert, and Falk [Gutachter] Weih. "Analysis of Wt1 function using a conditional knock-out mouse model / Ralph Sierig ; Gutachter: Christoph Englert, Falk Weih." Jena : Friedrich-Schiller-Universität Jena, 2010. http://d-nb.info/1177668505/34.
Повний текст джерелаЧастини книг з теми "Knockin mouse model"
Huang, Weihua, Wenhao Xu, and Ming D. Li. "Mouse Models: Knockouts/Knockins." In Addiction Medicine, 181–99. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-0338-9_9.
Повний текст джерелаBertoni, Arinna, Ignazia Prigione, Sabrina Chiesa, Isabella Ceccherini, Marco Gattorno, and Anna Rubartelli. "A Knock-In Mouse Model of Cryopyrin-Associated Periodic Syndromes." In Methods in Molecular Biology, 281–97. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3350-2_19.
Повний текст джерелаRumney, Robin M. H., and Dariusz C. Górecki. "Knockout and Knock-in Mouse Models to Study Purinergic Signaling." In Methods in Molecular Biology, 17–43. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9717-6_2.
Повний текст джерелаGoitre, Luca, Claudia Fornelli, Alessia Zotta, Andrea Perrelli, and Saverio Francesco Retta. "Production of KRIT1-knockout and KRIT1-knockin Mouse Embryonic Fibroblasts as Cellular Models of CCM Disease." In Methods in Molecular Biology, 151–67. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0640-7_12.
Повний текст джерелаLarsen, Erik Hviid, and Jens Nørkær Sørensen. "Stationary and Nonstationary Ion and Water Flux Interactions in Kidney Proximal Tubule: Mathematical Analysis of Isosmotic Transport by a Minimalistic Model." In Reviews of Physiology, Biochemistry and Pharmacology, 101–47. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/112_2019_16.
Повний текст джерелаGu, Bin, Marina Gertsenstein, and Eszter Posfai. "Generation of Large Fragment Knock-In Mouse Models by Microinjecting into 2-Cell Stage Embryos." In Methods in Molecular Biology, 89–100. New York, NY: Springer US, 2019. http://dx.doi.org/10.1007/978-1-4939-9837-1_7.
Повний текст джерелаParrington, John. "Next Year’s Models." In Redesigning Life, 111–32. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198766834.003.0006.
Повний текст джерелаCorbett, Brian, and Jeannie Chin. "Mouse models in bioscience research." In Tools and Techniques in Biomolecular Science. Oxford University Press, 2013. http://dx.doi.org/10.1093/hesc/9780199695560.003.0019.
Повний текст джерелаLiu, Wei, Xin Wang, and Elizabeth J. Cartwright. "Transgenesis." In Molecular Biology and Biotechnology, 155–90. 7th ed. The Royal Society of Chemistry, 2021. http://dx.doi.org/10.1039/9781788017862-00155.
Повний текст джерелаLevy, Isaac, Matthew Starost, Evan Ball, Fabio Rueda Faucz, Spyros Koliavasillis, Anelia Horvath, Kitman Tsang, et al. "Phosphodiesterase 11A (Pde11a) Expression in Mouse Tissues and Characterization of a Pde11a Mouse Knock-Out Model." In BASIC/TRANSLATIONAL - Development & Epigenetics of Steroid Biology & Neoplasia, P1–41—P1–41. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part1.p2.p1-41.
Повний текст джерелаТези доповідей конференцій з теми "Knockin mouse model"
Ma, Hechun, Yi Li, Ping Yang, Renxing Zhang, Dongxiao Feng, Jian Fei, Ruilin Sun, and Daniel X. He. "14 Humanized TFR1/CD71 knockin mouse model enables in vivo assessment of TFR1-targeted antibody therapies for cancer and beyond to across the blood-brain barrier." In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.0014.
Повний текст джерелаMahmoud, Ahmed M., Bunyen Teng, S. Jamal Mustafa, and Osama M. Mukdadi. "High-Frequency Ultrasound Tissue Classification of Atherosclerotic Plaques in an APOE-KO Mouse Model Using Spectral Analysis." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-13061.
Повний текст джерелаWan, William, and Rudolph L. Gleason. "Collagen Fiber Angle Quantification of Carotid Arteries From Fibulin-5 Null Mice." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53685.
Повний текст джерелаXiong, Shunbin, Yun Zhang, and Guillermina Lozano. "Abstract B07: Gain of function activities of p53R245W in a conditional knock-in mouse model." In Abstracts: AACR Special Conference on Tumor Metastasis; November 30-December 3, 2015; Austin, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.tummet15-b07.
Повний текст джерелаBertoni, Arinna, Sonia Carta, Chiara Baldovini, Federica Penco, Enrica Balza, Silvia Borghini, Marco DI Duca, et al. "OP0106 A NOVEL KNOCK-IN MOUSE MODEL OF CAPS THAT DEVELOPS AMYLOIDOSIS: THERAPEUTIC EFFICACY OF PROTON PUMP INHIBITORS." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.5727.
Повний текст джерелаYoshida, Kyoko, Claire Reeves, Jan Kitajewski, Ronald Wapner, Joy Vink, Michael Fernandez, and Kristin Myers. "Anthrax Toxin Receptor 2 Knock-Out and Wild Type Mouse Cervix Exhibit Time-Dependent Mechanical Properties." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80732.
Повний текст джерелаDiaz Martinez, Myriam, Masoud Ghamari-Langroudi, Aliya Gifford, Roger Cone, and E. B. Welch. "Automated pipeline to analyze non-contact infrared images of the paraventricular nucleus specific leptin receptor knock-out mouse model." In SPIE Medical Imaging, edited by Barjor Gimi and Robert C. Molthen. SPIE, 2015. http://dx.doi.org/10.1117/12.2082102.
Повний текст джерелаHilhorst, Maria H., Liesbeth Houkes, Hanneke Korsten, Monique Mommersteeg, Jan Trapman, and Rob Ruijtenbeek. "Abstract 4046: Direct detection of AKT/PKB activity in a Pten knock out mouse model using dynamic peptide microarrays." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-4046.
Повний текст джерелаSong, Ihn Young, Atul Kumar, Reyno Delrosario, Jian-Hua Mao, and Allan Balmain. "Abstract LB-258: The human Aurora-A kinase Phe31Ile polymorphism affects cancer susceptibility in a knock-in mouse model." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-lb-258.
Повний текст джерелаHummel, S., L. Slemann, J. Gnoerich, L. H. Kunze, G. Biechele, P. E. Sanchez, C. Haass та ін. "F-18-florbetaben-PET shows distinct distribution patterns of β-amyloid in different knock-in AD mouse models". У 60. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1746038.
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